NU7441 (KU-57788) 化学構造
分子量: 413.49

高品質保証

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MSDS

製品説明

  • Compare DNA-PK Inhibitors
    DNA-PK製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 NU7441 (KU-57788)は一種の高度有効的で、選択性的なDNA-PK阻害剤で、無細胞試験でIC50値が14 nMになって、PI3Kも抑制して、このIC50値が5μMになります。
ターゲット DNA-PK
IC50 14 nM [1]
In vitro試験 NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H1770 M1LyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEKxOFMh|ryP M1zYWHNCVkeHUh?=
A172 MnL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMUWzNVYh|ryP NFHqZ2tUSU6JRWK=
NCI-H526 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\rTG1KSzVyPUCuNlg1ODdizszN M1:wd3NCVkeHUh?=
HDLM-2 M4\Hdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonqTWM2OD1yLkOyN|Q2KM7:TR?= NFfSN4hUSU6JRWK=
HuO-3N1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK5PG9KSzVyPUCuOFY3OzZizszN M1m2XHNCVkeHUh?=
NCI-SNU-1 NH\aTJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrYfnJKSzVyPUCuOlA6QTRizszN MorBV2FPT0WU
SK-N-AS MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPO[HlKSzVyPUCuOlIzOTZizszN NXHZU4ttW0GQR1XS
LoVo M3:0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn22TWM2OD1yLki2O|Q6KM7:TR?= MlH5V2FPT0WU
LAMA-84 M3XLSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwOUi4N|Mh|ryP M4HRTHNCVkeHUh?=
CTB-1 NXjMdphPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXidFRKSzVyPUGuNVE2PDZizszN Mn3NV2FPT0WU
KP-N-YS M4ftNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jVO2lEPTB;MT6xOFI{OSEQvF2= M3PLWHNCVkeHUh?=
HH M4\KTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTFwMUiwPVMh|ryP MYLTRW5ITVJ?
CHL-1 M3fGbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:zXGlEPTB;MT6yNVM3QCEQvF2= NVjLe|BNW0GQR1XS
NB7 M3HJU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrITWM2OD1zLkK0O|Q2KM7:TR?= M1LVZnNCVkeHUh?=
HL-60 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTFwM{ixPUDPxE1? NGPrNYZUSU6JRWK=
639-V NVK0e5ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnDRmhKSzVyPUGuOFQyOjhizszN NF;3[mVUSU6JRWK=
NCI-H1793 NGHld4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fkTGlEPTB;MT60OVg1KM7:TR?= M1\WUXNCVkeHUh?=
NEC8 Ml2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIi3TmRKSzVyPUGuOVU{PSEQvF2= NV3PSXhNW0GQR1XS
PA-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjaeIduUUN3ME2xMlU5Ojl2IN88US=> NXL2U2o5W0GQR1XS
D-423MG MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljnTWM2OD1zLk[5N|YyKM7:TR?= M1nMfHNCVkeHUh?=
NCI-H292 NUexPIozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGm0bHhKSzVyPUGuO|QxOTNizszN M2fOPHNCVkeHUh?=
SK-MEL-1 NUSwb2tlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4CxUWlEPTB;MT63PVQ4QSEQvF2= MnO3V2FPT0WU
LB2241-RCC M1HG[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\oTWM2OD1{LkG0NVQ3KM7:TR?= NYLGcJlHW0GQR1XS
SK-MEL-3 M1TPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnkcVl[UUN3ME2yMlE3PDlizszN MlnoV2FPT0WU
MHH-PREB-1 NV;iXmk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJwMU[2NFkh|ryP MVnTRW5ITVJ?
BFTC-905 NGXEOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvVTWM2OD1{LkG2Olg4KM7:TR?= M4fJN3NCVkeHUh?=
Ramos-2G6-4C10 NEn5bllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJwMUm5NFkh|ryP MmfvV2FPT0WU
G-361 M3;WWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWj5UZRGUUN3ME2yMlIyPjhizszN M3LrWHNCVkeHUh?=
MOLT-4 Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJwMkG4PFgh|ryP NWjsWmNOW0GQR1XS
DEL M{LWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L5ZWlEPTB;Mj6zOVU3PCEQvF2= M{LROHNCVkeHUh?=
MV-4-11 M1PLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\HTWM2OD1{LkO3N|kh|ryP MlrHV2FPT0WU
SK-NEP-1 MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PDZWlEPTB;Mj6zPFc5OyEQvF2= NFLOXo1USU6JRWK=
RS4-11 M4G4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7vbIJUUUN3ME2yMlU3ODJ|IN88US=> M3W5THNCVkeHUh?=
HuH-7 M{Pq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnDTWM2OD1{LkW2O|AzKM7:TR?= M1LjTXNCVkeHUh?=
A101D NVzNTIRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjPToV7UUN3ME2yMlYyOzN6IN88US=> M3T6W3NCVkeHUh?=
KG-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LRcGlEPTB;Mj62O|kzPCEQvF2= MkCzV2FPT0WU
KALS-1 NVThbHJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X0PWlEPTB;Mj62PVY{OyEQvF2= NYrKOJYxW0GQR1XS
VMRC-RCZ MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXQPVhNUUN3ME2yMlc4OzJ6IN88US=> NGXXcJRUSU6JRWK=
SK-UT-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3THTWlEPTB;Mz6xOVMyKM7:TR?= MkC1V2FPT0WU
SW962 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTNwMkCzOVIh|ryP NGDoU2VUSU6JRWK=
DBTRG-05MG NFnKZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jUW2lEPTB;Mz6yPFA5PSEQvF2= MnSyV2FPT0WU
PANC-08-13 M2TxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLyeJNKSzVyPUOuOFEzPzhizszN M17CS3NCVkeHUh?=
QIMR-WIL NVOxW2FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTKPGRKSzVyPUOuOFE{PDFizszN NV2yR|lGW0GQR1XS
SK-MEL-30 NF;x[IFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzGUIt{UUN3ME2zMlQzPTl6IN88US=> NGSydnJUSU6JRWK=
697 NGHn[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDkS2FpUUN3ME2zMlQ1QTl|IN88US=> MkPRV2FPT0WU
NY M2jaOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TvT2lEPTB;Mz60OVAzOiEQvF2= NWHVb4FnW0GQR1XS
ES7 Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqwTWM2OD1|LkS2O|I6KM7:TR?= Mn\yV2FPT0WU
JVM-3 M3rrSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[5TWM2OD1|LkS4NFc4KM7:TR?= NFPCOnZUSU6JRWK=
U031 NUnz[HF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrITWM2OD1|LkW5N|Y5KM7:TR?= M1K4[HNCVkeHUh?=
BHT-101 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXvTWM2OD1|LkW5PVg2KM7:TR?= M2fZWnNCVkeHUh?=
8305C NYnHTlJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTNwNkG3N|Yh|ryP Ml\EV2FPT0WU
MG-63 NXjvc3ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj0TWM2OD1|Lk[yOlc3KM7:TR?= M2fXSHNCVkeHUh?=
NOS-1 NETjWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTNwNkWzNVIh|ryP NH2xb41USU6JRWK=
YH-13 NX;ufppHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLQTWM2OD1|Lki3NVg6KM7:TR?= MV7TRW5ITVJ?
LXF-289 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHiTWM2OD1|LkmxNFQyKM7:TR?= M2Dad3NCVkeHUh?=
GOTO M3P4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q3TmlEPTB;Mz65NVQ6KM7:TR?= NHS4clBUSU6JRWK=
EKVX MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjaUWxKSzVyPUSuNlI2OjRizszN M{Xi[HNCVkeHUh?=
CAL-51 NYTrd5RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXYb|hHUUN3ME20MlI1QDV2IN88US=> M{KyWHNCVkeHUh?=
AN3-CA NV7I[odpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjNTWM2OD12LkK1PFE{KM7:TR?= MnqyV2FPT0WU
IA-LM NXi1Ro9[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnkWGpKSzVyPUSuNlc6OzVizszN M4nRUXNCVkeHUh?=
KU-19-19 MkfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn34TWM2OD12LkOyPVIyKM7:TR?= MWLTRW5ITVJ?
A704 NE\ZRohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTRwNEC4PFgh|ryP NH\kRYFUSU6JRWK=
RH-18 NGHqcnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4SwdmlEPTB;ND60OFk2OyEQvF2= NV7ZR4ZrW0GQR1XS
IST-MEL1 NEnkXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTRwNUiyOlMh|ryP NF\PVVBUSU6JRWK=
LU-134-A MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTRwNUm2PFUh|ryP NV;CWJpCW0GQR1XS
SF126 NFfLcnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoToTWM2OD12Lk[wO|E2KM7:TR?= MnXNV2FPT0WU
EFO-27 Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIG1cYFKSzVyPUSuOlY2OjVizszN MXvTRW5ITVJ?
SN12C NG[3OmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXiWYpKSzVyPUSuO|E5QThizszN M1fLO3NCVkeHUh?=
L-363 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DvS2lEPTB;ND63O|EyPiEQvF2= M4nMe3NCVkeHUh?=
MEL-HO NXf2ZZlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3JepBpUUN3ME20Mlc4QTh7IN88US=> NVnkfW9nW0GQR1XS
TYK-nu MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTC[mZKSzVyPUSuPFAyOjhizszN M1XYN3NCVkeHUh?=
MDA-MB-415 M{LsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjpRVF1UUN3ME21MlAxOzF2IN88US=> NUTGTI95W0GQR1XS
HCC70 NGX6Z5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTVwMEO5N|kh|ryP NXLxXWhzW0GQR1XS
IGROV-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vRbGlEPTB;NT6yOVI6OiEQvF2= Ml;EV2FPT0WU
NCI-H1355 NXPjc5RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK2S4RKSzVyPUWuNlk3KM7:TR?= NI\WR3dUSU6JRWK=
23132-87 MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHHTWM2OD13LkOyNFI1KM7:TR?= MVjTRW5ITVJ?
NB69 NIfyO|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK0bFV[UUN3ME21MlMzPDJizszN MVHTRW5ITVJ?
HSC-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzWO|VKSzVyPUWuOFE4PzNizszN MULTRW5ITVJ?
KYSE-410 NVn0blhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\ITWM2OD13LkS3OlM3KM7:TR?= NVz6TGhuW0GQR1XS
GCIY M3;0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDQfYs4UUN3ME21MlUyOzd6IN88US=> NXLRU3k2W0GQR1XS
A427 MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvhZ|VGUUN3ME21MlU{PjZzIN88US=> M3T0VHNCVkeHUh?=
ChaGo-K-1 NYn4VZJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1mzS2lEPTB;NT61OlU6QSEQvF2= MmD0V2FPT0WU
PFSK-1 NXnvcnZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTVwNkKxPVQh|ryP MWPTRW5ITVJ?
MLMA Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrtW3pKSzVyPUWuPFM3ODZizszN MVfTRW5ITVJ?
RVH-421 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTZwMEezN|gh|ryP M3HMXHNCVkeHUh?=
LB1047-RCC M1e2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jlNGlEPTB;Nj6xO|UzOiEQvF2= MofIV2FPT0WU
MHH-NB-11 NVHBelZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W4bWlEPTB;Nj6zNlczOSEQvF2= NED2T|lUSU6JRWK=
J-RT3-T3-5 NFLOelBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{m0TWlEPTB;Nj62N|I6OSEQvF2= MXTTRW5ITVJ?
UM-UC-3 NYnMRnFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGThW3VKSzVyPU[uOlQ{OzRizszN M3n5WHNCVkeHUh?=
IST-SL1 NW\EV2NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\3TWM2OD14Lk[5N|Y6KM7:TR?= M{S5cnNCVkeHUh?=
NB14 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW4TWM2OD14Lke5O|YyKM7:TR?= M3nuXnNCVkeHUh?=
NBsusSR NHzTfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrETWM2OD14LkiyOVAzKM7:TR?= NV7je5dmW0GQR1XS
D-263MG NFfpR3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLKPVI5UUN3ME22MlkyODZ6IN88US=> NI[xRmlUSU6JRWK=
NCI-H2347 M1[wPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml2xTWM2OD14LkmzNlE{KM7:TR?= MX7TRW5ITVJ?
ES8 Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPCTWM2OD14Lkm3OVg5KM7:TR?= MX3TRW5ITVJ?
786-0 NFTzbG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TJemlEPTB;Nz6wPVc5PiEQvF2= M1HONHNCVkeHUh?=
EPLC-272H MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTdwMU[yOFYh|ryP NF3iNpBUSU6JRWK=
CAPAN-1 M3LEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTVTWM2OD15LkK0N|U6KM7:TR?= NYnsT2NUW0GQR1XS
NCI-H82 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLVRoVpUUN3ME23MlI3PjV7IN88US=> NUPRbVI2W0GQR1XS
G-402 M1;GUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe3TWM2OD15LkOwNFUyKM7:TR?= NGPteZFUSU6JRWK=
SW982 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPLTWM2OD15LkOwNlA{KM7:TR?= M{D1TnNCVkeHUh?=
OVCAR-4 MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle0TWM2OD15LkOxN|I5KM7:TR?= MY\TRW5ITVJ?
KARPAS-299 MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnzdXhlUUN3ME23MlMzPjJ{IN88US=> NVHoW|ZQW0GQR1XS
MIA-PaCa-2 NWLKPXBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvXcnR5UUN3ME23MlM3QDJ|IN88US=> NEHuNJlUSU6JRWK=
AU565 NInneZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HHbmlEPTB;Nz61PVg{OyEQvF2= NFX3bnNUSU6JRWK=
GAMG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\2TWM2OD15Lk[0NVMyKM7:TR?= NWnobWNGW0GQR1XS
HuO9 Mnu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\iTWM2OD15LkexO|Q{KM7:TR?= M3jM[HNCVkeHUh?=
ACN MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{OzNWlEPTB;Nz63OFM{KM7:TR?= MoXHV2FPT0WU
RO82-W-1 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjiR5JKSzVyPUeuO|Q2OzNizszN NETuVm5USU6JRWK=
NKM-1 M3y2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vqeWlEPTB;Nz63OFk2PSEQvF2= M3O1O3NCVkeHUh?=
CAL-12T MnTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rwT2lEPTB;Nz65OFM2OiEQvF2= NE\tcG1USU6JRWK=
FADU M3PWV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moq5TWM2OD16LkCzOlU1KM7:TR?= MX;TRW5ITVJ?
NCI-H28 M{\GWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRThwMU[5OlIh|ryP NWHW[WR7W0GQR1XS
LCLC-97TM1 NXXj[lF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPpd456UUN3ME24MlIyOTJ{IN88US=> Mom3V2FPT0WU
CHP-134 M4rjZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf2doxNUUN3ME24MlI1OTh3IN88US=> MXTTRW5ITVJ?
HT-1080 NX\nTm1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HjRmlEPTB;OD6yOVA6OyEQvF2= NIPETWNUSU6JRWK=
PC-3 NUi0[pNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRThwMkezPVIh|ryP M{TSRnNCVkeHUh?=
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VA-ES-BJ MmLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRThwM{S2PFYh|ryP MWTTRW5ITVJ?
HT Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rUdmlEPTB;OD6zOlQ6KM7:TR?= NYTYfWZXW0GQR1XS
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OAW-42 NYnxbI9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLQemRwUUN3ME24Mlk2QTZ2IN88US=> NFrze|RUSU6JRWK=
A549 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXtTWM2OD17LkC5OlEzKM7:TR?= MUDTRW5ITVJ?
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HCC1937 NYTLNVBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXETXo2UUN3ME25MlY6QDZ3IN88US=> NFH5bWpUSU6JRWK=
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CAL-72 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\ScnhiUUN3ME2xNE45ODl2IN88US=> MoqyV2FPT0WU
SK-MEL-28 NEL0O|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTvU29CUUN3ME2xNE45OjB{IN88US=> MX\TRW5ITVJ?
C32 M{S5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFyLkizOFch|ryP MnvjV2FPT0WU
NCI-H1155 Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzBcohRUUN3ME2xNE45Ozd4IN88US=> NF\rZY1USU6JRWK=
BB49-HNC MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDxSnNiUUN3ME2xNE45PTh4IN88US=> M330XHNCVkeHUh?=
GMS-10 M4XvfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\1RWlEPTB;MUCuPFk4OSEQvF2= M{LW[nNCVkeHUh?=
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NCI-H1563 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;wbHNUUUN3ME2xNU4yODFzIN88US=> NUjwOItiW0GQR1XS
CAL-54 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvhTY54UUN3ME2xNU41QDFzIN88US=> M1zBV3NCVkeHUh?=
WM-115 MlPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvLcGh1UUN3ME2xNU43QDJ2IN88US=> MkXuV2FPT0WU
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NCI-H650 NWrOV5pXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnmeWlYUUN3ME2xNU45QTZzIN88US=> MlXYV2FPT0WU
TE-11 NYjQboFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXf3Z4NtUUN3ME2xNU46OzF3IN88US=> NGLFTZJUSU6JRWK=
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D-283MED NYP1emh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLj[5lUUUN3ME2xNk4xPTZ7IN88US=> MWDTRW5ITVJ?
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BALL-1 M361TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfMUnBiUUN3ME2xNk4zPjZ{IN88US=> NFHMToNUSU6JRWK=
GT3TKB NWHjPIhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[wT2lEPTB;MUKuN|A4PCEQvF2= MoHFV2FPT0WU
HOP-92 M{XIOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjEfplkUUN3ME2xNk42OjN|IN88US=> NWPFOWZSW0GQR1XS
M14 NFXlTFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTF|LkCzN|Uh|ryP NXj4NZlFW0GQR1XS
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Becker M3PSNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DKZWlEPTB;MUOuNFU5KM7:TR?= MYHTRW5ITVJ?
ES5 NHjweGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTF|LkGzOVYh|ryP NHXr[XRUSU6JRWK=
NCI-H2030 MlXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXBZlNKSzVyPUGzMlIxPjJizszN NH7mWIVUSU6JRWK=
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NCI-H1092 Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjzZYhbUUN3ME2xN{44PDd3IN88US=> M{[1TXNCVkeHUh?=
8-MG-BA M2\DdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXCR5lKSzVyPUGzMlc2OTNizszN NYS2c3d{W0GQR1XS
CAL-27 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjjTWM2OD1zND6wO|I4KM7:TR?= NXrnO45tW0GQR1XS
AGS MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXKW|lGUUN3ME2xOE4yOzF7IN88US=> NH7ucIZUSU6JRWK=
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BFTC-909 NEPUV5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7kc4hlUUN3ME2xOE42ODV3IN88US=> NVHMXmM{W0GQR1XS
D-566MG NYnneZV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlP4TWM2OD1zND63O|A3KM7:TR?= MU\TRW5ITVJ?
MZ7-mel NVP1W|doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjicHlLUUN3ME2xOU4yODZ5IN88US=> MVzTRW5ITVJ?
TE-5 M3HOVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;GbmtKSzVyPUG1MlI{OzNizszN NIX2[oZUSU6JRWK=
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ME-180 NEO3flZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF3LkS3PFMh|ryP MoLhV2FPT0WU
MS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTF3LkW2NlMh|ryP MmrHV2FPT0WU
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LOXIMVI NW\1THl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGxOZN{UUN3ME2xOU45QTF7IN88US=> MUDTRW5ITVJ?
NCI-H1304 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PoSmlEPTB;MUWuPFkzQCEQvF2= NY\3TXU5W0GQR1XS
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SW1783 NEXyPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF4LkC5PVMh|ryP M2PPbHNCVkeHUh?=
EGI-1 NEfGWIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\5d445UUN3ME2xOk42OzZ3IN88US=> MU\TRW5ITVJ?
KGN MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jFTGlEPTB;MU[uOVU5PiEQvF2= Ml7ZV2FPT0WU
PANC-03-27 Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[3e4E4UUN3ME2xOk44PjZ{IN88US=> MUDTRW5ITVJ?
RH-1 NHG3SmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGe0TphKSzVyPUG2MlgzPSEQvF2= NImyPGZUSU6JRWK=
HT-1376 M1m5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTF4Lki0OFYh|ryP NF7FVYxUSU6JRWK=
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TK10 NIj0[VZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTZTWM2OD1zNz6wNFc6KM7:TR?= NG\WR3dUSU6JRWK=
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RPMI-8866 NHrMcZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXPTWM2OD1zNz6wOlk6KM7:TR?= M1nUOHNCVkeHUh?=
LNCaP-Clone-FGC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTF5LkWyNFEh|ryP M{LmR3NCVkeHUh?=
NCI-H2291 NUT0PZBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XPd2lEPTB;MUiuOFM1PSEQvF2= MV\TRW5ITVJ?
T47D MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXxTWM2OD1zOD60PFgh|ryP NYrweWtoW0GQR1XS
A204 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\6VGlEPTB;MUiuOVQ2OiEQvF2= NYDmeIdSW0GQR1XS
HT-144 NGXlW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF6Lke0Nlch|ryP M3XvdHNCVkeHUh?=
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HCC1806 NG\NNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkewTWM2OD1zOT6xOVkyKM7:TR?= MV7TRW5ITVJ?
NCI-H596 NVO3S5lHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnRWWMzUUN3ME2xPU43OzlzIN88US=> MVTTRW5ITVJ?
K-562 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHniV2tKSzVyPUG5Mlg6OjZizszN NUjzOIg2W0GQR1XS
D-336MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTF7LkmzNlIh|ryP MXjTRW5ITVJ?
SK-MEL-2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFSzOoJKSzVyPUKwMlE2PTlizszN MoHLV2FPT0WU
HEC-1 M4rINmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPnO2JKSzVyPUKwMlQ6PzhizszN MXnTRW5ITVJ?
EW-13 NGr4bYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzQTXhKSzVyPUKwMlU1PDNizszN NXjy[mF1W0GQR1XS
Hs-578-T M{jjV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fKU2lEPTB;MkCuOVU5OyEQvF2= MUjTRW5ITVJ?
SJSA-1 NH3BOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXjW3BYUUN3ME2yNE42Pjh6IN88US=> NE\V[GlUSU6JRWK=
RCC10RGB MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7q[3ZmUUN3ME2yNE43PzF7IN88US=> MY\TRW5ITVJ?
LAN-6 NY[xZ3Z6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vjWWlEPTB;MkGuNFM6PiEQvF2= NYXNZpUxW0GQR1XS
NCI-H1048 NX3wNmh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWO2bpliUUN3ME2yNU4zOjV6IN88US=> MX;TRW5ITVJ?
CW-2 NUDHfY5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJzLkK3NFUh|ryP MlvSV2FPT0WU
HCC2157 M{HJR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJzLkO2JO69VQ>? MkL6V2FPT0WU
EW-22 M{\rNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJzLkO3OkDPxE1? MkTQV2FPT0WU
A253 M3ewe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nHNGlEPTB;MkGuOFQ5OSEQvF2= M{jq[3NCVkeHUh?=
BE-13 MlzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jKfmlEPTB;MkGuOlEyOyEQvF2= NV7V[nA{W0GQR1XS
KINGS-1 MlPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXexT45qUUN3ME2yNU43OzF4IN88US=> MVLTRW5ITVJ?
ETK-1 M2nFXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvOSWg3UUN3ME2yNU45OTV{IN88US=> MULTRW5ITVJ?
NCI-H2452 M2HNPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJzLki2OFch|ryP NFP1PFlUSU6JRWK=
HPAF-II M4n1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrsbm1KSzVyPUKxMlg6OjNizszN NE\XWIVUSU6JRWK=
D-542MG MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJzLkmwOlkh|ryP NUD2N3hiW0GQR1XS
NCI-H630 NVrqW2RCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G3TGlEPTB;MkKuNFI6PiEQvF2= M3KwNHNCVkeHUh?=
TGBC11TKB MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJ{LkC0PUDPxE1? MVXTRW5ITVJ?
BCPAP NIrydVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlz2TWM2OD1{Mj62NVEh|ryP NWnGSVI4W0GQR1XS
HLE NXn3ZpVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PFbWlEPTB;MkKuOlk4KM7:TR?= M4TxTnNCVkeHUh?=
NCI-H727 NFrieYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\JTWM2OD1{Mj63N|Uh|ryP M1qzbnNCVkeHUh?=
RD Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\LVGlEPTB;MkKuO|UyQCEQvF2= NY\hcphtW0GQR1XS
NCI-H522 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPLTWM2OD1{Mj64OFMyKM7:TR?= MorPV2FPT0WU
CGTH-W-1 NV[4[I5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL5NmVKSzVyPUKzMlA3PDFizszN MkPSV2FPT0WU
SK-LU-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XaNWlEPTB;MkOuOFY5OyEQvF2= NUL4VYNSW0GQR1XS
BB65-RCC NEDMSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJ|Lke4OlMh|ryP M{HSbXNCVkeHUh?=
HSC-3 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SzcWlEPTB;MkOuPFUzPyEQvF2= Mn35V2FPT0WU
SK-MES-1 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJ2LkCxOlEh|ryP NI\XNJZUSU6JRWK=
DB NVu3N2RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3zTWM2OD1{ND6xNFI5KM7:TR?= MoTtV2FPT0WU
HO-1-N-1 NVuwbox7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXORXpKSzVyPUK0MlMxQTNizszN NWTUfFZpW0GQR1XS
MKN1 MoSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfY[XJ7UUN3ME2yOE43QCEQvF2= MW\TRW5ITVJ?
MN-60 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJ2Lki1NVkh|ryP M1[1V3NCVkeHUh?=
8505C NITEU3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\DXWlEPTB;MkWuNVg1PSEQvF2= NYDNeWk6W0GQR1XS
COLO-320-HSR MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\zWHBKSzVyPUK1MlIzODhizszN NYDMVo1FW0GQR1XS
BB30-HNC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fOTWlEPTB;MkWuNlQ5OyEQvF2= NXLlZ4hCW0GQR1XS
KM12 M4n6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvx[4VuUUN3ME2yOU42QDB5IN88US=> NWHCbpdkW0GQR1XS
NB13 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvKTWM2OD1{NT61PFk5KM7:TR?= MWHTRW5ITVJ?
HCC2998 NGPxN2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPE[JNLUUN3ME2yOk4xOjh|IN88US=> NYXIZWR3W0GQR1XS
U-118-MG NGHQVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfvTWM2OD1{Nj6wPFA5KM7:TR?= Mkm5V2FPT0WU
NB10 NXfVNGlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTiTWM2OD1{Nj6yN|Qh|ryP NEP3U5RUSU6JRWK=
SK-LMS-1 NEHLVmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLSTWM2OD1{Nz6wO|A1KM7:TR?= NIG4dWFUSU6JRWK=
SW1573 Mn3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;STmpKSzVyPUK3MlEyKM7:TR?= M1\1eHNCVkeHUh?=
LB373-MEL-D MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPSOJBHUUN3ME2yO{4yOjl2IN88US=> MVvTRW5ITVJ?
DK-MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;xfJJOUUN3ME2yO{4yQDF5IN88US=> MkHLV2FPT0WU
RMG-I MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDwdIZKSzVyPUK3MlIxOjlizszN MmfkV2FPT0WU
SW1088 NUPrW4NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEW3T3lKSzVyPUK3MlUxPDJizszN M1XXWXNCVkeHUh?=
SK-OV-3 NWnEdnhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;XN2lEPTB;MkeuO|U6OyEQvF2= NYrwNFY2W0GQR1XS
KP-N-YN NV\VcGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nuZWlEPTB;MkeuPFA1OyEQvF2= NETBWFZUSU6JRWK=
RPMI-7951 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnizTWM2OD1{OD6yOFU3KM7:TR?= M{\5dnNCVkeHUh?=
CaR-1 NWjSV2Y4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fHfmlEPTB;MkiuOVU5OiEQvF2= MYLTRW5ITVJ?
MKN7 NHjtdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHBcVB[UUN3ME2yPE42QTZ2IN88US=> NHW4VI5USU6JRWK=
CHP-212 Mn\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrsTWM2OD1{OD63OFAyKM7:TR?= MV7TRW5ITVJ?
KYSE-450 NXS3PWp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\NTWM2OD1{OD64NFkyKM7:TR?= M1q3cHNCVkeHUh?=
RXF393 NHHqPGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\ybmlEPTB;MkmuNlkxPiEQvF2= MVTTRW5ITVJ?
P30-OHK MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJ7LkOwOFgh|ryP MX;TRW5ITVJ?
Ca9-22 M1rXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJ7LkSyPVkh|ryP MYTTRW5ITVJ?
RT-112 M2r4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHNd|BMUUN3ME2yPU41PjFzIN88US=> NXfOfm5uW0GQR1XS
ES1 NHTqOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3vTWM2OD1{OT64OVQ1KM7:TR?= NYf4TWJ1W0GQR1XS
HCE-4 M{nXbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjrc|MxUUN3ME2yPU45Pzh4IN88US=> NGW4dldUSU6JRWK=
AM-38 M3j6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLnbItRUUN3ME2zNE4xPjB4IN88US=> NX;He3JpW0GQR1XS
AsPC-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTNyLkiwOVMh|ryP NYHzNndjW0GQR1XS
TE-9 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\lTWM2OD1|MD64O|M4KM7:TR?= M2HX[nNCVkeHUh?=
HuP-T4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HjOWlEPTB;M{CuPVY{QCEQvF2= NEDrdmFUSU6JRWK=
LB2518-MEL M1Wz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37LbGlEPTB;M{GuNFc1PCEQvF2= MnfzV2FPT0WU
NCI-H1703 NIfVRXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;aOWlEPTB;M{GuNFkxPSEQvF2= M1HtO3NCVkeHUh?=
NCI-H2228 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTNzLkS2OVEh|ryP Mlu1V2FPT0WU
SCC-4 M1\wUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDKV3pKSzVyPUOxMlkyQDFizszN Ml3YV2FPT0WU
KNS-81-FD MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vvXmlEPTB;M{KuNFEzQCEQvF2= NHjTfGFUSU6JRWK=
NTERA-S-cl-D1 MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTSc|lKSzVyPUOyMlA4OzlizszN M3jNPXNCVkeHUh?=
Daoy NIrwSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f1VmlEPTB;M{KuNFg{QCEQvF2= M2H1bXNCVkeHUh?=
ES4 MoT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nq[2lEPTB;M{KuN|kzOiEQvF2= M1jvOnNCVkeHUh?=
MHH-ES-1 M3;5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTN{LkS4O|Ih|ryP MlTnV2FPT0WU
C-33-A M2T3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TORWlEPTB;M{KuO|czQCEQvF2= Mkf2V2FPT0WU
BHY NGjkT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHoOm06UUN3ME2zNk46PDl3IN88US=> M3nKZnNCVkeHUh?=
Detroit562 MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPSXGdTUUN3ME2zN{43PjV5IN88US=> MVrTRW5ITVJ?
EW-1 MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHwOotKSzVyPUOzMlk{OjJizszN MlK5V2FPT0WU
NCI-H1395 NHL2ZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPoTWM2OD1|ND6wO|k6KM7:TR?= M2TSNnNCVkeHUh?=
KM-H2 NIPvSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTq[oVoUUN3ME2zOk41PzR|IN88US=> M1q1ZXNCVkeHUh?=
NCI-H520 NXvOOnFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X3VGlEPTB;M{[uO|U1OSEQvF2= NVzsc25OW0GQR1XS
D-392MG NEfzPIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fkbGlEPTB;M{euN|M1PCEQvF2= MmTYV2FPT0WU
NOMO-1 M4n3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTwVJc5UUN3ME2zO{45ODh7IN88US=> NHjiOWlUSU6JRWK=
TE-6 M{fBS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT5WppKSzVyPUO4MlEzPCEQvF2= M4nqfHNCVkeHUh?=
HT-3 NFjlbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnwOJVuUUN3ME2zPE41PDN4IN88US=> MlHmV2FPT0WU
RPMI-8226 NULJdXh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW5T3hKUUN3ME2zPE46PTF7IN88US=> NE\MUY5USU6JRWK=
U251 NFnIT4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;wR3RPUUN3ME2zPU4xOTJ2IN88US=> Mm\zV2FPT0WU
GCT MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33XPGlEPTB;M{muNVg2OiEQvF2= NVmzZVdoW0GQR1XS
A431 NYH1V2FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTN7LkG4PVQh|ryP NVvBdppTW0GQR1XS
TE-12 M{XKfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIX2b2RKSzVyPUO5MlI1PDhizszN MoLSV2FPT0WU
HMV-II M{\aXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rHcmlEPTB;M{muOVA1PyEQvF2= NXHUfXp[W0GQR1XS
IST-MES1 MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTRyLkG1NFIh|ryP MkfXV2FPT0WU
SW13 MoHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1yzbmlEPTB;NECuOVE6KM7:TR?= NUD5SlZWW0GQR1XS
SF295 NIHrTHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUC0eGZSUUN3ME20NE45ODZ4IN88US=> M4ixPXNCVkeHUh?=
MDA-MB-157 NYLSepJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTRyLkm0OlIh|ryP NH;INIhUSU6JRWK=
TE-1 NYLQb2ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTRzLki3NVQh|ryP MXfTRW5ITVJ?
HuCCT1 MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTuUmx5UUN3ME20Nk42Ojh7IN88US=> MVrTRW5ITVJ?
KYSE-510 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHhTWM2OD12Mz6xO|U1KM7:TR?= NVfzeVJlW0GQR1XS
NCI-H358 NFvNU2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;zW4lNUUN3ME20OE4xOzB2IN88US=> MW\TRW5ITVJ?
SW900 NYr4T3FjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTR2LkC3OVgh|ryP NITBNo9USU6JRWK=
CAS-1 M3f4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPCfnZKSzVyPUS0MlA6QTFizszN NE[wN3FUSU6JRWK=
TE-8 M{\FSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTR2LkW2OVgh|ryP MnLQV2FPT0WU
P12-ICHIKAWA MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTR2Lk[xNVIh|ryP MVTTRW5ITVJ?
YKG-1 NIDhZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XmUGlEPTB;NESuO|gyKM7:TR?= M4HpZXNCVkeHUh?=
SNU-C2B M2[2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYf3VZdFUUN3ME20OE44QTB|IN88US=> NUjxb3lCW0GQR1XS
LCLC-103H MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHHTWM2OD12ND64O|A{KM7:TR?= MWTTRW5ITVJ?
U-87-MG M4T4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S0ZWlEPTB;NEWuNVAzOiEQvF2= NGHZZmNUSU6JRWK=
HAL-01 NV;jTGh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;jZW9KSzVyPUS1MlE{PzlizszN M1rSVnNCVkeHUh?=
OVCAR-8 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTQWGtKSzVyPUS1MlM2PjRizszN NYHudWZKW0GQR1XS
KYSE-150 Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTR5LkGwOVIh|ryP MlnOV2FPT0WU
OE33 NX[0W5k3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULPfVRYUUN3ME20O{4yPDJ7IN88US=> NHjDVWtUSU6JRWK=
CAL-62 MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXCdFZuUUN3ME20O{41ODZ6IN88US=> NGf0PIlUSU6JRWK=
TCCSUP M3z6emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1K0VWlEPTB;NEeuOlI3PCEQvF2= MmDzV2FPT0WU
H4 NUTmVIo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTR5Lk[2NlEh|ryP NX3tbYFiW0GQR1XS
CP66-MEL M1TsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR6LkC3NFQh|ryP NVHLOnRpW0GQR1XS
SNB75 M4rSfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjHNVZKSzVyPUS4MlE5PzRizszN NFu0elFUSU6JRWK=
Mo-T Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn3TWM2OD12OD6yO|kh|ryP Mmq2V2FPT0WU
BT-549 NGraSHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLQTWM2OD12OD6zO|I6KM7:TR?= NVi2dGZ{W0GQR1XS
IGR-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HDT2lEPTB;NEiuOlY1PSEQvF2= MkCwV2FPT0WU
NCI-H1299 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLVXGNKSzVyPUS4MlczPDhizszN NUL1dndrW0GQR1XS
ALL-PO NUHD[GxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPUTWM2OD12OT65NlY5KM7:TR?= M4jwdXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]
臨床試験
特集

プロトコル (参考用のみ)

細胞アッセイ: [2]

細胞株 SW620, LoVo, V3-YAC and V3 cells
濃度 0.5 μM or 1 μM
反応時間 17 hours
実験の流れ The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.

動物実験: [2]

動物モデル Female rude mice bearing SW620 xenografts
製剤 Sterile 0.9% sodium chloride solution
投薬量 10 mg/kg
投与方法 Intraperitoneally administrated

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download NU7441 (KU-57788) SDF
分子量 413.49
化学式

C25H19NO3S

CAS No. 503468-95-9
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 4 mg/mL warming (9.67 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

文献中の引用 (15)

Frequently Asked Questions

  • Question 1
    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

    Answer: Slight color variation due to different processing is normal and usually doesn't interfere with the function.

技術サポート&よくある質問(FAQ)

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Tags: NU7441 (KU-57788)を買う | NU7441 (KU-57788)供給者 | NU7441 (KU-57788)を購入する | NU7441 (KU-57788)費用 | NU7441 (KU-57788)生産者 | オーダーNU7441 (KU-57788) | NU7441 (KU-57788)代理店
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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