NU7441 (KU-57788) 化学構造
分子量: 413.49

高品質保証

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MSDS

製品説明

  • Compare DNA-PK Inhibitors
    DNA-PK製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 NU7441 (KU-57788)は一種の高度有効的で、選択性的なDNA-PK阻害剤で、無細胞試験でIC50値が14 nMになって、PI3Kも抑制して、このIC50値が5μMになります。
ターゲット DNA-PK
IC50 14 nM [1]
In vitro試験 NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H1770 M3zoTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEKxOFMh|ryP MXjTRW5ITVJ?
A172 NILMU3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mny4TWM2OD1yLkG1N|E3KM7:TR?= NEfodGtUSU6JRWK=
NCI-H526 M1ThZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMki0NFch|ryP NYXKRVA{W0GQR1XS
HDLM-2 NX3tcIRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwM{KzOFUh|ryP MWXTRW5ITVJ?
HuO-3N1 NW\LUYNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT4NIZKSzVyPUCuOFY3OzZizszN MmHzV2FPT0WU
NCI-SNU-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PDNGlEPTB;MD62NFk6PCEQvF2= MkHuV2FPT0WU
SK-N-AS MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHsTWM2OD1yLk[yNlE3KM7:TR?= NF7ORlZUSU6JRWK=
LoVo NYP6bZlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[3TWM2OD1yLki2O|Q6KM7:TR?= NELxUWNUSU6JRWK=
LAMA-84 NEHGfGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7jTWM2OD1yLkm4PFM{KM7:TR?= Mnf3V2FPT0WU
CTB-1 NX7uSZlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37l[2lEPTB;MT6xNVU1PiEQvF2= NUGx[3ZrW0GQR1XS
KP-N-YS M{DZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXR[29KSzVyPUGuNVQzOzFizszN MofuV2FPT0WU
HH NVHMbXJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\J[29KSzVyPUGuNVgxQTNizszN M{jDTHNCVkeHUh?=
CHL-1 NY\DTnIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnSyTWM2OD1zLkKxN|Y5KM7:TR?= MUfTRW5ITVJ?
NB7 MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX6wTIozUUN3ME2xMlI1PzR3IN88US=> M4LDNnNCVkeHUh?=
HL-60 M{nWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHiNZFDUUN3ME2xMlM5OTlizszN MVjTRW5ITVJ?
639-V MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTFwNESxNlgh|ryP NFvhT49USU6JRWK=
NCI-H1793 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHf1VXdKSzVyPUGuOFU5PCEQvF2= NXzwUFBuW0GQR1XS
NEC8 NHX4SpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqwTpRKSzVyPUGuOVU{PSEQvF2= MoXRV2FPT0WU
PA-1 NUnrRotDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TXV2lEPTB;MT61PFI6PCEQvF2= Mo[zV2FPT0WU
D-423MG MnnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\COmlEPTB;MT62PVM3OSEQvF2= NV7sVlloW0GQR1XS
NCI-H292 NVi4eIkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:0TWM2OD1zLke0NFE{KM7:TR?= NV;4TpBtW0GQR1XS
SK-MEL-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfwSHdKSzVyPUGuO|k1PzlizszN MkTTV2FPT0WU
LB2241-RCC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXmxT5kyUUN3ME2yMlE1OTR4IN88US=> M2rmVnNCVkeHUh?=
SK-MEL-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInu[oJKSzVyPUKuNVY1QSEQvF2= Mo\BV2FPT0WU
MHH-PREB-1 MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJwMU[2NFkh|ryP Ml23V2FPT0WU
BFTC-905 NGrLT2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTMTWM2OD1{LkG2Olg4KM7:TR?= M1f6PXNCVkeHUh?=
Ramos-2G6-4C10 NHvYNG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTJwMUm5NFkh|ryP NVrs[XFPW0GQR1XS
G-361 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn5V2VKSzVyPUKuNlE3QCEQvF2= NGOyRnRUSU6JRWK=
MOLT-4 M4L4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJwMkG4PFgh|ryP MlXPV2FPT0WU
DEL NFzBPGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknqTWM2OD1{LkO1OVY1KM7:TR?= NG\kOHJUSU6JRWK=
MV-4-11 MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTiZYJrUUN3ME2yMlM4OzlizszN MnTwV2FPT0WU
SK-NEP-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjnSlBEUUN3ME2yMlM5Pzh|IN88US=> NWfwXHk6W0GQR1XS
RS4-11 NFvyOWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXjTWM2OD1{LkW2NFI{KM7:TR?= NUjjPGJXW0GQR1XS
HuH-7 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrqTWM2OD1{LkW2O|AzKM7:TR?= NWK5RmhrW0GQR1XS
A101D M1W5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHFTYxKSzVyPUKuOlE{OzhizszN NGDYZ|ZUSU6JRWK=
KG-1 NVe5PVNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJwNke5NlQh|ryP NGTCTZJUSU6JRWK=
KALS-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLSU5VHUUN3ME2yMlY6PjN|IN88US=> Mo\PV2FPT0WU
VMRC-RCZ MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO0ZnBiUUN3ME2yMlc4OzJ6IN88US=> NHu3bW9USU6JRWK=
SK-UT-1 NX35VFhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fFbmlEPTB;Mz6xOVMyKM7:TR?= NWX3OppFW0GQR1XS
SW962 M3\FVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTNwMkCzOVIh|ryP NYPTR3FxW0GQR1XS
DBTRG-05MG M3rnUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXlUIc{UUN3ME2zMlI5ODh3IN88US=> NHLXdm9USU6JRWK=
PANC-08-13 NV60eIFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LpPWlEPTB;Mz60NVI4QCEQvF2= MmnRV2FPT0WU
QIMR-WIL M3[3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonTTWM2OD1|LkSxN|QyKM7:TR?= M3TT[nNCVkeHUh?=
SK-MEL-30 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rqb2lEPTB;Mz60NlU6QCEQvF2= MonMV2FPT0WU
697 M4H2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvVOIZKSzVyPUOuOFQ6QTNizszN M4fnSHNCVkeHUh?=
NY MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr6TWM2OD1|LkS1NFIzKM7:TR?= M3TU[HNCVkeHUh?=
ES7 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP0fVBoUUN3ME2zMlQ3PzJ7IN88US=> MnHmV2FPT0WU
JVM-3 NUL4SHJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTKRVN[UUN3ME2zMlQ5ODd5IN88US=> NUfVeYVIW0GQR1XS
U031 M4foZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmX6TWM2OD1|LkW5N|Y5KM7:TR?= NGnxPI1USU6JRWK=
BHT-101 NWGzOZpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD4TWM2OD1|LkW5PVg2KM7:TR?= NITmSpFUSU6JRWK=
8305C MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLURoM1UUN3ME2zMlYyPzN4IN88US=> NWXsTI9NW0GQR1XS
MG-63 Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTNwNkK2O|Yh|ryP NYXYbXFvW0GQR1XS
NOS-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HNdGlEPTB;Mz62OVMyOiEQvF2= MVLTRW5ITVJ?
YH-13 NWHXOXNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTNwOEexPFkh|ryP MkDYV2FPT0WU
LXF-289 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDMTWM2OD1|LkmxNFQyKM7:TR?= NFnhPFhUSU6JRWK=
GOTO MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TyUmlEPTB;Mz65NVQ6KM7:TR?= M3vOOHNCVkeHUh?=
EKVX NWjHU491T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnroTWM2OD12LkKyOVI1KM7:TR?= NW\jWocyW0GQR1XS
CAL-51 MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnIeWtKSzVyPUSuNlQ5PTRizszN MVrTRW5ITVJ?
AN3-CA NGSyd2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrKc4dIUUN3ME20MlI2QDF|IN88US=> MUfTRW5ITVJ?
IA-LM NIf1UnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LpT2lEPTB;ND6yO|k{PSEQvF2= Mmq3V2FPT0WU
KU-19-19 NIHyNXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jvNGlEPTB;ND6zNlkzOSEQvF2= NYm1enI2W0GQR1XS
A704 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzQVoVKSzVyPUSuOFA5QDhizszN NVS5SnZyW0GQR1XS
RH-18 NWOyVG9{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWn0e2lNUUN3ME20MlQ1QTV|IN88US=> M3r3e3NCVkeHUh?=
IST-MEL1 MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjmOY9oUUN3ME20MlU5OjZ|IN88US=> MnjsV2FPT0WU
LU-134-A NUXMd5NWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXSbYNUUUN3ME20MlU6Pjh3IN88US=> M3PISXNCVkeHUh?=
SF126 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nlRWlEPTB;ND62NFcyPSEQvF2= MWnTRW5ITVJ?
EFO-27 M13Pcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTRwNk[1NlUh|ryP MXjTRW5ITVJ?
SN12C Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnyZZpvUUN3ME20MlcyQDl6IN88US=> MUTTRW5ITVJ?
L-363 MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTRwN{exNVYh|ryP NYHLZ4xYW0GQR1XS
MEL-HO NXHL[VFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\vVYdKSzVyPUSuO|c6QDlizszN NYW0dJYxW0GQR1XS
TYK-nu MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DRXGlEPTB;ND64NFEzQCEQvF2= NF\pS4dUSU6JRWK=
MDA-MB-415 NGfKTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;mdFFMUUN3ME21MlAxOzF2IN88US=> NVX3Zm9zW0GQR1XS
HCC70 M1XCbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTY[IVKSzVyPUWuNFM6OzlizszN M3rBNHNCVkeHUh?=
IGROV-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPiW5lKUUN3ME21MlI2Ojl{IN88US=> NHvnNYtUSU6JRWK=
NCI-H1355 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonNTWM2OD13LkK5OkDPxE1? Mkm0V2FPT0WU
23132-87 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7TTWM2OD13LkOyNFI1KM7:TR?= M4TLeXNCVkeHUh?=
NB69 M3jpdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi5SXI{UUN3ME21MlMzPDJizszN NFu3OG1USU6JRWK=
HSC-2 MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\4NmlEPTB;NT60NVc4OyEQvF2= M{fNNXNCVkeHUh?=
KYSE-410 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTVwNEe2N|Yh|ryP NFyycFNUSU6JRWK=
GCIY M3PFe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi2XWE4UUN3ME21MlUyOzd6IN88US=> MkfPV2FPT0WU
A427 MnG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvJTWM2OD13LkWzOlYyKM7:TR?= MorBV2FPT0WU
ChaGo-K-1 NYXCO5hmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPSTWM2OD13LkW2OVk6KM7:TR?= NHridHdUSU6JRWK=
PFSK-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnRSJR1UUN3ME21MlYzOTl2IN88US=> NYfocnJSW0GQR1XS
MLMA Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS1TWM2OD13LkizOlA3KM7:TR?= NUXNN5l3W0GQR1XS
RVH-421 NYrrSGI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLvTWM2OD14LkC3N|M5KM7:TR?= NWPTd2x7W0GQR1XS
LB1047-RCC Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm2N4M4UUN3ME22MlE4PTJ{IN88US=> MnrkV2FPT0WU
MHH-NB-11 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUWx[mdmUUN3ME22MlMzPzJzIN88US=> Mn74V2FPT0WU
J-RT3-T3-5 NIj3OHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3T[VVXUUN3ME22MlY{OjlzIN88US=> NGfNPHdUSU6JRWK=
UM-UC-3 NVOyW3dLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4G3UmlEPTB;Nj62OFM{PCEQvF2= NWflZ2x4W0GQR1XS
IST-SL1 NHqxO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonUTWM2OD14Lk[5N|Y6KM7:TR?= MkPHV2FPT0WU
NB14 M4T2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u1T2lEPTB;Nj63PVc3OSEQvF2= M{ize3NCVkeHUh?=
NBsusSR MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTZwOEK1NFIh|ryP MofIV2FPT0WU
D-263MG NYLR[49wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj4fnZqUUN3ME22MlkyODZ6IN88US=> NEfFe3pUSU6JRWK=
NCI-H2347 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLxTWM2OD14LkmzNlE{KM7:TR?= NGrRWpFUSU6JRWK=
ES8 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NID6fZVKSzVyPU[uPVc2QDhizszN NXHucZI5W0GQR1XS
786-0 NY\hVGFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\LTWM2OD15LkC5O|g3KM7:TR?= MofSV2FPT0WU
EPLC-272H MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTdwMU[yOFYh|ryP MWjTRW5ITVJ?
CAPAN-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTdwMkSzOVkh|ryP M4rlXnNCVkeHUh?=
NCI-H82 NYfPNW9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PDPWlEPTB;Nz6yOlY2QSEQvF2= MYfTRW5ITVJ?
G-402 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTifYlmUUN3ME23MlMxODVzIN88US=> MVHTRW5ITVJ?
SW982 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrpTHA2UUN3ME23MlMxOjB|IN88US=> M2\FcXNCVkeHUh?=
OVCAR-4 Mmi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrCTWM2OD15LkOxN|I5KM7:TR?= NGDX[VlUSU6JRWK=
KARPAS-299 M3jpdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe5WW41UUN3ME23MlMzPjJ{IN88US=> NHqw[WtUSU6JRWK=
MIA-PaCa-2 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfYTWM2OD15LkO2PFI{KM7:TR?= M3;ETXNCVkeHUh?=
AU565 M13tZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfMcY16UUN3ME23MlU6QDN|IN88US=> MXfTRW5ITVJ?
GAMG NHzobVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjPeZJKSzVyPUeuOlQyOzFizszN NVLlblZbW0GQR1XS
HuO9 MnXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;XWpl3UUN3ME23MlcyPzR|IN88US=> Mn;LV2FPT0WU
ACN MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;CWpZbUUN3ME23Mlc1OzNizszN MYLTRW5ITVJ?
RO82-W-1 NYnEZod[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HlR2lEPTB;Nz63OFU{OyEQvF2= MYjTRW5ITVJ?
NKM-1 NFHYV|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4eyemlEPTB;Nz63OFk2PSEQvF2= NHPZWG1USU6JRWK=
CAL-12T M3SyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXNTWM2OD15Lkm0N|UzKM7:TR?= M{TSWnNCVkeHUh?=
FADU NGXH[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\OO5FKSzVyPUiuNFM3PTRizszN MULTRW5ITVJ?
NCI-H28 NHzoRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj4TIU2UUN3ME24MlE3QTZ{IN88US=> NETmNWNUSU6JRWK=
LCLC-97TM1 NIXnZ45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLITWM2OD16LkKxNVIzKM7:TR?= MkT0V2FPT0WU
CHP-134 NV\p[2NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHmRXpPUUN3ME24MlI1OTh3IN88US=> MmLOV2FPT0WU
HT-1080 NVu2eY9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrROlhUUUN3ME24MlI2ODl|IN88US=> MVvTRW5ITVJ?
PC-3 NHfjUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnrTWM2OD16LkK3N|kzKM7:TR?= M1TKZXNCVkeHUh?=
SNU-449 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi2RotKSzVyPUiuNlc6OyEQvF2= M2PNWnNCVkeHUh?=
VA-ES-BJ MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRThwM{S2PFYh|ryP M17ieXNCVkeHUh?=
HT NGP6U4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\VNWlEPTB;OD6zOlQ6KM7:TR?= MV\TRW5ITVJ?
HOS NULv[JJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHoTFZWUUN3ME24MlM4PTh7IN88US=> MWHTRW5ITVJ?
KNS-62 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorRTWM2OD16LkO3O|YzKM7:TR?= NX3OTVdIW0GQR1XS
OAW-42 NULwNItCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmewTWM2OD16Lkm1PVY1KM7:TR?= M17LZnNCVkeHUh?=
A549 NFPqNYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXqT4JKSzVyPUmuNFk3OTJizszN M1TN[HNCVkeHUh?=
CAKI-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP6WJpKSzVyPUmuNVY3OSEQvF2= M4OzfXNCVkeHUh?=
HCC1937 NYLNXI17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPjN24zUUN3ME25MlY6QDZ3IN88US=> NHHr[2xUSU6JRWK=
GI-ME-N M3Xmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTlwN{CxN|ch|ryP M4TROnNCVkeHUh?=
DU-4475 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvwRYE{UUN3ME25Mlk3QTN7IN88US=> M{jQR3NCVkeHUh?=
EM-2 NG\uUG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFyLkK0NlYh|ryP NEXyUnZUSU6JRWK=
NCI-H1755 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjtUmdKSzVyPUGwMlI1OjhizszN NUnmenFUW0GQR1XS
NCI-H1437 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2OwXWlEPTB;MUCuOVczPSEQvF2= M4rJd3NCVkeHUh?=
VM-CUB-1 MlvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TNOWlEPTB;MUCuOlE3PCEQvF2= MXHTRW5ITVJ?
A2058 NF3CbYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vaU2lEPTB;MUCuOlQxPCEQvF2= MknvV2FPT0WU
BPH-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\k[VlKSzVyPUGwMlcyPDVizszN M3XVfHNCVkeHUh?=
NB5 NYDDXVhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vQZWlEPTB;MUCuO|U2QSEQvF2= M3zZcXNCVkeHUh?=
G-401 MoTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFyLke2NlYh|ryP NVm1NoU4W0GQR1XS
CAL-72 M4nvXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzmOINYUUN3ME2xNE45ODl2IN88US=> MYLTRW5ITVJ?
SK-MEL-28 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFyLkiyNFIh|ryP NVzBcGViW0GQR1XS
C32 NX;zPGg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTFyLkizOFch|ryP M3;N[HNCVkeHUh?=
NCI-H1155 NWDmUolrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjjTWM2OD1zMD64N|c3KM7:TR?= MnzJV2FPT0WU
BB49-HNC NEPuXpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTFyLki1PFYh|ryP NHjnZYpUSU6JRWK=
GMS-10 M3fo[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHte4JKSzVyPUGwMlg6PzFizszN MUjTRW5ITVJ?
K5 M2\SRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFyLkmwO|Eh|ryP NVrOXHFDW0GQR1XS
OS-RC-2 NXHJXoVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFzLkC1OVkh|ryP NVfKRll3W0GQR1XS
HTC-C3 M160T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED1eXpKSzVyPUGxMlA4OTRizszN Mkm1V2FPT0WU
LB996-RCC NH:wTZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LuO2lEPTB;MUGuNFczOyEQvF2= NGnnT5JUSU6JRWK=
NCI-H1563 NVvEdYwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn2TGZIUUN3ME2xNU4yODFzIN88US=> NHXVUI5USU6JRWK=
CAL-54 NXTJdmRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m5c2lEPTB;MUGuOFgyOSEQvF2= MVnTRW5ITVJ?
WM-115 NYfCPHU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFzLk[4NlQh|ryP MX\TRW5ITVJ?
COLO-684 Mn\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFzLkeyOlch|ryP NHnBOZhUSU6JRWK=
HOP-62 NInQ[2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkmzTWM2OD1zMT63OVA5KM7:TR?= MlG3V2FPT0WU
NCI-H650 NXXXc5J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWSxVFJ[UUN3ME2xNU45QTZzIN88US=> NIHK[pFUSU6JRWK=
TE-11 MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PtWGlEPTB;MUGuPVMyPSEQvF2= MWDTRW5ITVJ?
COLO-679 NEHZOoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjuTWM2OD1zMT65OFYh|ryP M{C0bnNCVkeHUh?=
FTC-133 MljmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO5elRKSzVyPUGyMlAxPzZizszN M2Pq[XNCVkeHUh?=
D-283MED NXi5bm4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrLW4xKSzVyPUGyMlA2PjlizszN MWfTRW5ITVJ?
SK-PN-DW NE\LUW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LueGlEPTB;MUKuNVkxOiEQvF2= MXPTRW5ITVJ?
BALL-1 NWLaeI0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXlOYdvUUN3ME2xNk4zPjZ{IN88US=> NVP1SGFrW0GQR1XS
GT3TKB MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT0XIlDUUN3ME2xNk4{ODd2IN88US=> MVvTRW5ITVJ?
HOP-92 NVPnOlNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XWRWlEPTB;MUKuOVI{OyEQvF2= M{C5enNCVkeHUh?=
M14 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi4WZBKSzVyPUGzMlA{OzVizszN NXe5RZFDW0GQR1XS
SKG-IIIa NYDpSYw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHhbpJKSzVyPUGzMlA2PTRizszN NUXKb4xGW0GQR1XS
Becker M1rUcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\QR3hKSzVyPUGzMlA2QCEQvF2= NYjFUnBvW0GQR1XS
ES5 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DwZ2lEPTB;MUOuNVM2PiEQvF2= NV3JZmhqW0GQR1XS
NCI-H2030 M3LvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF|LkKwOlIh|ryP NYnRRnZjW0GQR1XS
SNU-423 MlLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoD5TWM2OD1zMz6zPFEh|ryP MVfTRW5ITVJ?
CP50-MEL-B NXjZU4E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTF|Lk[yN|Ih|ryP NX7PbXJ5W0GQR1XS
NCI-H1092 NUjPNY5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHlepNKSzVyPUGzMlc1PzVizszN NYq1[JN1W0GQR1XS
8-MG-BA NFrSTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDmXIZtUUN3ME2xN{44PTF|IN88US=> M1jUWHNCVkeHUh?=
CAL-27 NGqxOVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfnfHJKSzVyPUG0MlA4OjdizszN NWjTUZZMW0GQR1XS
AGS M37uOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLNcJJMUUN3ME2xOE4yOzF7IN88US=> M{n1SnNCVkeHUh?=
MZ2-MEL NH7hVXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTF2LkG0PFgh|ryP MWnTRW5ITVJ?
BFTC-909 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTF2LkWwOVUh|ryP NVjkVpZQW0GQR1XS
D-566MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XUT2lEPTB;MUSuO|cxPiEQvF2= MYLTRW5ITVJ?
MZ7-mel NH;KXoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzWfYZ1UUN3ME2xOU4yODZ5IN88US=> M17RZnNCVkeHUh?=
TE-5 M2DFO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PjUWlEPTB;MUWuNlM{OyEQvF2= NVW5VZY4W0GQR1XS
647-V NY\RTItZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS5TWM2OD1zNT6yO|A2KM7:TR?= MlLrV2FPT0WU
DMS-114 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzGNG9KSzVyPUG1MlMzQTFizszN M1vncXNCVkeHUh?=
ME-180 Mm\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j1[mlEPTB;MUWuOFc5OyEQvF2= M131e3NCVkeHUh?=
MS-1 M3vYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjCTWM2OD1zNT61OlI{KM7:TR?= NWPFcYJMW0GQR1XS
NUGC-3 M2X2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDCTWM2OD1zNT62NlQ2KM7:TR?= MXfTRW5ITVJ?
GB-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn3NodKSzVyPUG1MlY1OzdizszN M1X6SHNCVkeHUh?=
LOXIMVI NFno[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDz[JNHUUN3ME2xOU45QTF7IN88US=> NYXGOYJ7W0GQR1XS
NCI-H1304 NFXFO|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jWRWlEPTB;MUWuPFkzQCEQvF2= M2PUbHNCVkeHUh?=
KURAMOCHI MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXSfm0{UUN3ME2xOU46PzFizszN NInpcYdUSU6JRWK=
SW1783 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTF4LkC5PVMh|ryP NEfsTJBUSU6JRWK=
EGI-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTF4LkWzOlUh|ryP MlLJV2FPT0WU
KGN NWDpUXBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXYZYhKSzVyPUG2MlU2QDZizszN MVTTRW5ITVJ?
PANC-03-27 NWHselhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfKblhIUUN3ME2xOk44PjZ{IN88US=> M1fDOXNCVkeHUh?=
RH-1 M{jwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnsd4hKSzVyPUG2MlgzPSEQvF2= M{XxeHNCVkeHUh?=
HT-1376 NFS5S5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[3[2lEPTB;MU[uPFQ1PiEQvF2= Mn7oV2FPT0WU
ZR-75-30 Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjj[pFKSzVyPUG2Mlk{PjFizszN MUfTRW5ITVJ?
TI-73 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DydGlEPTB;MU[uPVQxQCEQvF2= MWrTRW5ITVJ?
TK10 MoPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPteFRKSzVyPUG3MlAxPzlizszN MWrTRW5ITVJ?
SW684 M4DxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TGfmlEPTB;MUeuNFE2PCEQvF2= NV;yU|liW0GQR1XS
RPMI-8866 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTF5LkC2PVkh|ryP M{DpWXNCVkeHUh?=
LNCaP-Clone-FGC NIjvfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13NemlEPTB;MUeuOVIxOSEQvF2= MXzTRW5ITVJ?
NCI-H2291 NX\yTndLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n2b2lEPTB;MUiuOFM1PSEQvF2= NI\IPGhUSU6JRWK=
T47D M1XwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;lWWlEPTB;MUiuOFg5KM7:TR?= NHzNVVRUSU6JRWK=
A204 MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTqbJdKSzVyPUG4MlU1PTJizszN MkKzV2FPT0WU
HT-144 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7XWZNKSzVyPUG4Mlc1OjdizszN MVfTRW5ITVJ?
MDA-MB-361 NUj1U|BTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrmTWM2OD1zOT6wO|E1KM7:TR?= NXzUSIExW0GQR1XS
HCC1806 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\IVGlEPTB;MUmuNVU6OSEQvF2= MULTRW5ITVJ?
NCI-H596 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTF7Lk[zPVEh|ryP NEm5TlRUSU6JRWK=
K-562 MnrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITSZppKSzVyPUG5Mlg6OjZizszN NHXoUnpUSU6JRWK=
D-336MG M3PleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfne|RKSzVyPUG5Mlk{OjJizszN NIXVfXdUSU6JRWK=
SK-MEL-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTJSop3UUN3ME2yNE4yPTV7IN88US=> MlW2V2FPT0WU
HEC-1 MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP6NVZKSzVyPUKwMlQ6PzhizszN NEjNdGxUSU6JRWK=
EW-13 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe5RZVKSzVyPUKwMlU1PDNizszN Ml73V2FPT0WU
Hs-578-T NX3CW3loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvSTWM2OD1{MD61OVg{KM7:TR?= NVPybVY6W0GQR1XS
SJSA-1 NWTUWnF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH2wcJJKSzVyPUKwMlU3QDhizszN NYPkcpp4W0GQR1XS
RCC10RGB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPMfGNKSzVyPUKwMlY4OTlizszN MXjTRW5ITVJ?
LAN-6 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PETmlEPTB;MkGuNFM6PiEQvF2= NXPRW481W0GQR1XS
NCI-H1048 NInrTHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHGbHlmUUN3ME2yNU4zOjV6IN88US=> MWPTRW5ITVJ?
CW-2 M3ztNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJzLkK3NFUh|ryP M3X3dXNCVkeHUh?=
HCC2157 NVe2dJBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHmzUodKSzVyPUKxMlM3KM7:TR?= M2XJdnNCVkeHUh?=
EW-22 NXjPXI04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXlTWM2OD1{MT6zO|Yh|ryP M324VHNCVkeHUh?=
A253 NFXMV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jGVmlEPTB;MkGuOFQ5OSEQvF2= Mk\BV2FPT0WU
BE-13 NFfpSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJzLk[xNVMh|ryP MUnTRW5ITVJ?
KINGS-1 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\YNZZHUUN3ME2yNU43OzF4IN88US=> M2DXWXNCVkeHUh?=
ETK-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFOyT2RKSzVyPUKxMlgyPTJizszN NVP5OoY2W0GQR1XS
NCI-H2452 MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJzLki2OFch|ryP M4jpU3NCVkeHUh?=
HPAF-II MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJzLki5NlMh|ryP M37WSXNCVkeHUh?=
D-542MG MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnITWM2OD1{MT65NFY6KM7:TR?= MWfTRW5ITVJ?
NCI-H630 NIrCVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT1OHpTUUN3ME2yNk4xOjl4IN88US=> MlLUV2FPT0WU
TGBC11TKB M4T3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{C1N2lEPTB;MkKuNFQ6KM7:TR?= MkXEV2FPT0WU
BCPAP M33hPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJ{Lk[xNUDPxE1? M{jwWXNCVkeHUh?=
HLE MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDpXYlKSzVyPUKyMlY6PyEQvF2= MkW5V2FPT0WU
NCI-H727 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrL[GVKSzVyPUKyMlc{PSEQvF2= MmD6V2FPT0WU
RD M4HpUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[1TWM2OD1{Mj63OVE5KM7:TR?= MXjTRW5ITVJ?
NCI-H522 NH3TSGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJ{Lki0N|Eh|ryP M{fwXXNCVkeHUh?=
CGTH-W-1 MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmT0TWM2OD1{Mz6wOlQyKM7:TR?= NHjOZpBUSU6JRWK=
SK-LU-1 M{HiTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3LWYFKSzVyPUKzMlQ3QDNizszN NIrseHJUSU6JRWK=
BB65-RCC NIfOU3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELuO2FKSzVyPUKzMlc5PjNizszN MUPTRW5ITVJ?
HSC-3 NFPufVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFexfIRKSzVyPUKzMlg2OjdizszN MVzTRW5ITVJ?
SK-MES-1 NG\tSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXzSWlXUUN3ME2yOE4xOTZzIN88US=> NGfFT|NUSU6JRWK=
DB NX\HVpdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\lTWM2OD1{ND6xNFI5KM7:TR?= NHyyO|VUSU6JRWK=
HO-1-N-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3iZnhbUUN3ME2yOE4{ODl|IN88US=> MnPiV2FPT0WU
MKN1 NFXJdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH75VpdKSzVyPUK0MlY5KM7:TR?= NWSxN2EzW0GQR1XS
MN-60 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTJ2Lki1NVkh|ryP M3PXfXNCVkeHUh?=
8505C MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJ3LkG4OFUh|ryP NGe3O5lUSU6JRWK=
COLO-320-HSR NIHwT5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX0bWNKSzVyPUK1MlIzODhizszN MX\TRW5ITVJ?
BB30-HNC M3Hy[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\yWGlEPTB;MkWuNlQ5OyEQvF2= MUjTRW5ITVJ?
KM12 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfIbW1KSzVyPUK1MlU5ODdizszN M1jGbXNCVkeHUh?=
NB13 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ3LkW4PVgh|ryP MVHTRW5ITVJ?
HCC2998 M2jqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe4R3ZKSzVyPUK2MlAzQDNizszN MkH5V2FPT0WU
U-118-MG NIDvPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHzXppuUUN3ME2yOk4xQDB6IN88US=> NFjsTYVUSU6JRWK=
NB10 NF[0e|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXjVlNbUUN3ME2yOk4zOzRizszN NFrzdHFUSU6JRWK=
SK-LMS-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHtUIl[UUN3ME2yO{4xPzB2IN88US=> NGnZW|ZUSU6JRWK=
SW1573 MkDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJ5LkGxJO69VQ>? M4rOdHNCVkeHUh?=
LB373-MEL-D M3GxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJ5LkGyPVQh|ryP NU\aN2VEW0GQR1XS
DK-MG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjKb2lvUUN3ME2yO{4yQDF5IN88US=> Ml\iV2FPT0WU
RMG-I MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvVbGNOUUN3ME2yO{4zODJ7IN88US=> M175[nNCVkeHUh?=
SW1088 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP5TWM2OD1{Nz61NFQzKM7:TR?= Mn\1V2FPT0WU
SK-OV-3 MnfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkW3TWM2OD1{Nz63OVk{KM7:TR?= MonpV2FPT0WU
KP-N-YN MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJ5LkiwOFMh|ryP MVfTRW5ITVJ?
RPMI-7951 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7sTWM2OD1{OD6yOFU3KM7:TR?= NYjvR2dbW0GQR1XS
CaR-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJ6LkW1PFIh|ryP MVXTRW5ITVJ?
MKN7 NHjmfIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmze3RKSzVyPUK4MlU6PjRizszN M1rPdnNCVkeHUh?=
CHP-212 NGjKcI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvTdY9KSzVyPUK4Mlc1ODFizszN MWLTRW5ITVJ?
KYSE-450 NVfMSVVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTGTWM2OD1{OD64NFkyKM7:TR?= MnTWV2FPT0WU
RXF393 MljJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;mUmlEPTB;MkmuNlkxPiEQvF2= MV\TRW5ITVJ?
P30-OHK M{jOXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPPeYV6UUN3ME2yPU4{ODR6IN88US=> NYjYTIk5W0GQR1XS
Ca9-22 MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X1[mlEPTB;MkmuOFI6QSEQvF2= NWrWd3BkW0GQR1XS
RT-112 NEfUb|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r6O2lEPTB;MkmuOFYyOSEQvF2= NIT3TZZUSU6JRWK=
ES1 Ml7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXTTWM2OD1{OT64OVQ1KM7:TR?= NV70NZB[W0GQR1XS
HCE-4 NU\oOpB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;ITWM2OD1{OT64O|g3KM7:TR?= NXOyfZJSW0GQR1XS
AM-38 NILGTXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzrWoNKSzVyPUOwMlA3ODZizszN MWDTRW5ITVJ?
AsPC-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTBN25KSzVyPUOwMlgxPTNizszN M13NZnNCVkeHUh?=
TE-9 NEf2U2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETUUW9KSzVyPUOwMlg4OzdizszN NVHyeWI4W0GQR1XS
HuP-T4 NHPCcGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3y0VWlEPTB;M{CuPVY{QCEQvF2= Ml;1V2FPT0WU
LB2518-MEL NWjYUFBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULSNoMyUUN3ME2zNU4xPzR2IN88US=> M3i4dXNCVkeHUh?=
NCI-H1703 MlTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi5cVZTUUN3ME2zNU4xQTB3IN88US=> MWLTRW5ITVJ?
NCI-H2228 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;XbmlEPTB;M{GuOFY2OSEQvF2= NIDuSohUSU6JRWK=
SCC-4 NIi2RWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNzLkmxPFEh|ryP MYPTRW5ITVJ?
KNS-81-FD MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHzd2xKSzVyPUOyMlAyOjhizszN M1vYb3NCVkeHUh?=
NTERA-S-cl-D1 MmfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH3XGhbUUN3ME2zNk4xPzN7IN88US=> NWO2SmxKW0GQR1XS
Daoy MlHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTN{LkC4N|gh|ryP M3\XXnNCVkeHUh?=
ES4 M2L1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGK3XopKSzVyPUOyMlM6OjJizszN NFnU[m1USU6JRWK=
MHH-ES-1 MmDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfT[XhtUUN3ME2zNk41QDd{IN88US=> MoP1V2FPT0WU
C-33-A MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nVemlEPTB;M{KuO|czQCEQvF2= NHL0fYRUSU6JRWK=
BHY MojTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LVRmlEPTB;M{KuPVQ6PSEQvF2= M4ryeXNCVkeHUh?=
Detroit562 M{\4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzF[WhZUUN3ME2zN{43PjV5IN88US=> Mn:5V2FPT0WU
EW-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37VNWlEPTB;M{OuPVMzOiEQvF2= M3zaTnNCVkeHUh?=
NCI-H1395 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjIZmN[UUN3ME2zOE4xPzl7IN88US=> MoOxV2FPT0WU
KM-H2 M{fpO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzCSoRKSzVyPUO2MlQ4PDNizszN MW\TRW5ITVJ?
NCI-H520 MkS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWC2T3V[UUN3ME2zOk44PTRzIN88US=> NFXTXVhUSU6JRWK=
D-392MG NYDvVXRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPHb4xKSzVyPUO3MlM{PDRizszN MlnEV2FPT0WU
NOMO-1 Mki5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK2TWM2OD1|Nz64NFg6KM7:TR?= MW\TRW5ITVJ?
TE-6 NV3h[21tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LEdWlEPTB;M{iuNVI1KM7:TR?= MWrTRW5ITVJ?
HT-3 M{nSSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjDT5YxUUN3ME2zPE41PDN4IN88US=> NX[4TJBsW0GQR1XS
RPMI-8226 M2\OW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLWTWM2OD1|OD65OVE6KM7:TR?= MVrTRW5ITVJ?
U251 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1njRWlEPTB;M{muNFEzPCEQvF2= MknJV2FPT0WU
GCT MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjkbI1iUUN3ME2zPU4yQDV{IN88US=> MWPTRW5ITVJ?
A431 M1fOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\NPWlEPTB;M{muNVg6PCEQvF2= Mm[wV2FPT0WU
TE-12 M2SzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTN7LkK0OFgh|ryP MXHTRW5ITVJ?
HMV-II M3z6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\STWM2OD1|OT61NFQ4KM7:TR?= NHHPbIJUSU6JRWK=
IST-MES1 MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTRyLkG1NFIh|ryP NFm4boZUSU6JRWK=
SW13 NEX1R3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\LRXJmUUN3ME20NE42OTlizszN NFfoZ|hUSU6JRWK=
SF295 NFvUZmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTRyLkiwOlYh|ryP NFH2VopUSU6JRWK=
MDA-MB-157 M{HtUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{OxWmlEPTB;NECuPVQ3OiEQvF2= Ml7CV2FPT0WU
TE-1 NGT4[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTRzLki3NVQh|ryP NXrT[m1DW0GQR1XS
HuCCT1 M1XYXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLpTWM2OD12Mj61Nlg6KM7:TR?= NUf4TY5HW0GQR1XS
KYSE-510 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTR|LkG3OVQh|ryP MVXTRW5ITVJ?
NCI-H358 Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXZephKSzVyPUS0MlA{ODRizszN MX\TRW5ITVJ?
SW900 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjTWVNKSzVyPUS0MlA4PThizszN MUHTRW5ITVJ?
CAS-1 NYe0TIpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\OcZVbUUN3ME20OE4xQTlzIN88US=> NHTKWZBUSU6JRWK=
TE-8 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\WZVQzUUN3ME20OE42PjV6IN88US=> MlHQV2FPT0WU
P12-ICHIKAWA MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTR2Lk[xNVIh|ryP MWHTRW5ITVJ?
YKG-1 NFLzbWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVuwXYZlUUN3ME20OE44QDFizszN Mk\QV2FPT0WU
SNU-C2B M2fV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PmR2lEPTB;NESuO|kxOyEQvF2= NWruZo1xW0GQR1XS
LCLC-103H MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIO3XXFKSzVyPUS0Mlg4ODNizszN MWnTRW5ITVJ?
U-87-MG M4Pudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fWb2lEPTB;NEWuNVAzOiEQvF2= MoX4V2FPT0WU
HAL-01 M1XsTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTR3LkGzO|kh|ryP Mn\vV2FPT0WU
OVCAR-8 M1PuVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3PTWM2OD12NT6zOVY1KM7:TR?= NHnqUJFUSU6JRWK=
KYSE-150 NX;BRoNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DqdWlEPTB;NEeuNVA2OiEQvF2= NGDEVGhUSU6JRWK=
OE33 M1PIfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\vTWM2OD12Nz6xOFI6KM7:TR?= MYjTRW5ITVJ?
CAL-62 MoXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTR5LkSwOlgh|ryP NEi4NoVUSU6JRWK=
TCCSUP NFvRclRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLwTWM2OD12Nz62NlY1KM7:TR?= MorWV2FPT0WU
H4 MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfsW|VtUUN3ME20O{43PjJzIN88US=> MVnTRW5ITVJ?
CP66-MEL NXe3Rmc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHYTWM2OD12OD6wO|A1KM7:TR?= NU[zUZN4W0GQR1XS
SNB75 M{DiRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvYbFhKSzVyPUS4MlE5PzRizszN M2HJXnNCVkeHUh?=
Mo-T MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLVVIlKSzVyPUS4MlI4QSEQvF2= NFXGSG9USU6JRWK=
BT-549 NX3EeXRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTR6LkO3Nlkh|ryP MVnTRW5ITVJ?
IGR-1 MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3uwcmlEPTB;NEiuOlY1PSEQvF2= NWO0VFh3W0GQR1XS
NCI-H1299 NUn2NYZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXKcGdKSzVyPUS4MlczPDhizszN M3zUTHNCVkeHUh?=
ALL-PO NGXZ[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3pW3VTUUN3ME20PU46OjZ6IN88US=> Mo[4V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]
臨床試験
特集

プロトコル (参考用のみ)

細胞アッセイ: [2]

細胞株 SW620, LoVo, V3-YAC and V3 cells
濃度 0.5 μM or 1 μM
反応時間 17 hours
実験の流れ The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.

動物実験: [2]

動物モデル Female rude mice bearing SW620 xenografts
製剤 Sterile 0.9% sodium chloride solution
投薬量 10 mg/kg
投与方法 Intraperitoneally administrated

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download NU7441 (KU-57788) SDF
分子量 413.49
化学式

C25H19NO3S

CAS No. 503468-95-9
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 4 mg/mL warming (9.67 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

文献中の引用 (15)

Frequently Asked Questions

  • Question 1
    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

    Answer: Slight color variation due to different processing is normal and usually doesn't interfere with the function.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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