NU7441 (KU-57788) 化学構造
分子量: 413.49

高品質保証

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Quality Control & MSDS

製品説明

  • Compare DNA-PK Inhibitors
    DNA-PK製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 NU7441 (KU-57788)は、14nMのIC50による非常に強力で選択的なDNAPK阻害剤です。
ターゲット DNA-PK
IC50 14 nM [1]
In vitro試験 NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H1770 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO5R21VUUN3ME2wMlAzOTR|IN88US=> NX;sWXoyW0GQR1XS
A172 MmTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPNRYhKSzVyPUCuNVU{OTZizszN NWqxVoFmW0GQR1XS
NCI-H526 M2fwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC1TWM2OD1yLkK4OFA4KM7:TR?= M1PPcnNCVkeHUh?=
HDLM-2 NWrPbIp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWeyWI1[UUN3ME2wMlMzOzR3IN88US=> M4PtdHNCVkeHUh?=
HuO-3N1 NH2yU2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7nb5hMUUN3ME2wMlQ3PjN4IN88US=> M3nyZnNCVkeHUh?=
NCI-SNU-1 NIixUXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwNkC5PVQh|ryP NEntd|RUSU6JRWK=
SK-N-AS MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwNkKyNVYh|ryP MlrPV2FPT0WU
LoVo NUL4TmJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkG3TWM2OD1yLki2O|Q6KM7:TR?= MoHMV2FPT0WU
LAMA-84 M1vLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkO2TWM2OD1yLkm4PFM{KM7:TR?= M1TwbXNCVkeHUh?=
CTB-1 M4HvWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPKWIxbUUN3ME2xMlEyPTR4IN88US=> NX6zT4d1W0GQR1XS
KP-N-YS NF6zWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTFwMUSyN|Eh|ryP NFy2RWZUSU6JRWK=
HH M2X3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fkUWlEPTB;MT6xPFA6OyEQvF2= MlfRV2FPT0WU
CHL-1 NX\EPGxwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LGZWlEPTB;MT6yNVM3QCEQvF2= NWPoWWdJW0GQR1XS
NB7 NETUSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\LRoNKSzVyPUGuNlQ4PDVizszN M2fyWnNCVkeHUh?=
HL-60 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFwM{ixPUDPxE1? NEXWPIVUSU6JRWK=
639-V NVq1UlZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLBV2FOUUN3ME2xMlQ1OTJ6IN88US=> NH:1PHlUSU6JRWK=
NCI-H1793 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXm4fWJPUUN3ME2xMlQ2QDRizszN M2rrTHNCVkeHUh?=
NEC8 Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFwNUWzOUDPxE1? NEHXTW5USU6JRWK=
PA-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPYXndLUUN3ME2xMlU5Ojl2IN88US=> M{myXHNCVkeHUh?=
D-423MG MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFwNkmzOlEh|ryP MVPTRW5ITVJ?
NCI-H292 M4DsXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTRWXJKSzVyPUGuO|QxOTNizszN MXTTRW5ITVJ?
SK-MEL-1 M{n3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG1[XNKSzVyPUGuO|k1PzlizszN MULTRW5ITVJ?
LB2241-RCC NYPtR2w2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV71VFA3UUN3ME2yMlE1OTR4IN88US=> M2n4PHNCVkeHUh?=
SK-MEL-3 NH3NVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHQTWM2OD1{LkG2OFkh|ryP M1TYRXNCVkeHUh?=
MHH-PREB-1 MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfXTWM2OD1{LkG2OlA6KM7:TR?= NFr4UnhUSU6JRWK=
BFTC-905 MmjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJwMU[2PFch|ryP NX\O[pdVW0GQR1XS
Ramos-2G6-4C10 MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\yTWM2OD1{LkG5PVA6KM7:TR?= MoPhV2FPT0WU
G-361 MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF2zfYpKSzVyPUKuNlE3QCEQvF2= NWfRT2QyW0GQR1XS
MOLT-4 M3;UcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nTNmlEPTB;Mj6yNVg5QCEQvF2= NFzOS4xUSU6JRWK=
DEL NY\x[llzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4WyO2lEPTB;Mj6zOVU3PCEQvF2= NEDiWZZUSU6JRWK=
MV-4-11 MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\zXHhKSzVyPUKuN|c{QSEQvF2= NUn4TJZ7W0GQR1XS
SK-NEP-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwM{i3PFMh|ryP M4WzbHNCVkeHUh?=
RS4-11 NFrUVHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe5TWM2OD1{LkW2NFI{KM7:TR?= MWfTRW5ITVJ?
HuH-7 M{nxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJwNU[3NFIh|ryP MVXTRW5ITVJ?
A101D MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnUPHNKSzVyPUKuOlE{OzhizszN NFPLR41USU6JRWK=
KG-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrpTWM2OD1{Lk[3PVI1KM7:TR?= NW\EZ2l3W0GQR1XS
KALS-1 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDSXmtKSzVyPUKuOlk3OzNizszN NUfq[INJW0GQR1XS
VMRC-RCZ NFXxeJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3oTGhKSzVyPUKuO|c{OjhizszN NH7pSo5USU6JRWK=
SK-UT-1 M1PVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HqVGlEPTB;Mz6xOVMyKM7:TR?= M3\lTXNCVkeHUh?=
SW962 NH;2NlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XibmlEPTB;Mz6yNFM2OiEQvF2= NHj6[VRUSU6JRWK=
DBTRG-05MG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWewV5JsUUN3ME2zMlI5ODh3IN88US=> M3i3VHNCVkeHUh?=
PANC-08-13 M1fNeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW5TWM2OD1|LkSxNlc5KM7:TR?= NG\hNnFUSU6JRWK=
QIMR-WIL M{e0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfkPYhMUUN3ME2zMlQyOzRzIN88US=> NF7zUZVUSU6JRWK=
SK-MEL-30 NEjFWlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;Lb2lEPTB;Mz60NlU6QCEQvF2= M4rZNnNCVkeHUh?=
697 MlHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTNwNES5PVMh|ryP NXn0bYFMW0GQR1XS
NY M3PQbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXhSmxlUUN3ME2zMlQ2ODJ{IN88US=> M4jhXXNCVkeHUh?=
ES7 NUD4Xnl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTNwNE[3Nlkh|ryP M1vBW3NCVkeHUh?=
JVM-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTNwNEiwO|ch|ryP NGPveXhUSU6JRWK=
U031 M2TFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnq5TWM2OD1|LkW5N|Y5KM7:TR?= MkHKV2FPT0WU
BHT-101 NWDBe|FWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnQTWM2OD1|LkW5PVg2KM7:TR?= MWPTRW5ITVJ?
8305C MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXDPIF1UUN3ME2zMlYyPzN4IN88US=> M{jrUXNCVkeHUh?=
MG-63 MlHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jqfGlEPTB;Mz62NlY4PiEQvF2= NIC1RXBUSU6JRWK=
NOS-1 Mm\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNwNkWzNVIh|ryP Mn\DV2FPT0WU
YH-13 NVq4R2NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XyeWlEPTB;Mz64O|E5QSEQvF2= M1S3U3NCVkeHUh?=
LXF-289 M2HCN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFWybI9KSzVyPUOuPVExPDFizszN MXPTRW5ITVJ?
GOTO NYnL[3J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTNwOUG0PUDPxE1? MnnUV2FPT0WU
EKVX MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTRwMkK1NlQh|ryP NVPQbVVnW0GQR1XS
CAL-51 NW\xfpk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTRwMkS4OVQh|ryP M2PheHNCVkeHUh?=
AN3-CA NEXnOZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHodm1sUUN3ME20MlI2QDF|IN88US=> Ml;BV2FPT0WU
IA-LM MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTRwMke5N|Uh|ryP Ml74V2FPT0WU
KU-19-19 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;Ld5o5UUN3ME20MlMzQTJzIN88US=> Ml[xV2FPT0WU
A704 NYjQPZIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTRwNEC4PFgh|ryP NF\5c2lUSU6JRWK=
RH-18 NVX1enAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:2TWM2OD12LkS0PVU{KM7:TR?= M2K4cXNCVkeHUh?=
IST-MEL1 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\xOZJKSzVyPUSuOVgzPjNizszN M2XDWnNCVkeHUh?=
LU-134-A NYC5No83T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS3TWM2OD12LkW5Olg2KM7:TR?= NEexdYRUSU6JRWK=
SF126 NHPzNW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfoeplKSzVyPUSuOlA4OTVizszN MU\TRW5ITVJ?
EFO-27 NGDVUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XBd2lEPTB;ND62OlUzPSEQvF2= M4\NV3NCVkeHUh?=
SN12C MnrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3UWoxKSzVyPUSuO|E5QThizszN M1fiW3NCVkeHUh?=
L-363 NEnkZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTRwN{exNVYh|ryP NEDONoxUSU6JRWK=
MEL-HO NVi0c2VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH23UFdKSzVyPUSuO|c6QDlizszN NEXGW45USU6JRWK=
TYK-nu MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\wTWM2OD12LkiwNVI5KM7:TR?= NX3NZnozW0GQR1XS
MDA-MB-415 NX61SVA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli5TWM2OD13LkCwN|E1KM7:TR?= MmPvV2FPT0WU
HCC70 NYLieIk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jFNGlEPTB;NT6wN|k{QSEQvF2= NGDyWXFUSU6JRWK=
IGROV-1 M2\FTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XyOGlEPTB;NT6yOVI6OiEQvF2= NUG0Rmc{W0GQR1XS
NCI-H1355 NEfVeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHnTWM2OD13LkK5OkDPxE1? MV;TRW5ITVJ?
23132-87 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTVwM{KwNlQh|ryP Ml\kV2FPT0WU
NB69 MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[wdlJKSzVyPUWuN|I1OiEQvF2= NXe5cVFjW0GQR1XS
HSC-2 M1jwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjzTWM2OD13LkSxO|c{KM7:TR?= M4DHUXNCVkeHUh?=
KYSE-410 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTVwNEe2N|Yh|ryP NGG2UI1USU6JRWK=
GCIY MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPCc41[UUN3ME21MlUyOzd6IN88US=> NF[5NIFUSU6JRWK=
A427 MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXtTWM2OD13LkWzOlYyKM7:TR?= MUXTRW5ITVJ?
ChaGo-K-1 NHj1O5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTKVlRoUUN3ME21MlU3PTl7IN88US=> MnHyV2FPT0WU
PFSK-1 NF;QcmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDhTWM2OD13Lk[yNVk1KM7:TR?= MkXiV2FPT0WU
MLMA NV;YfoE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjsTWM2OD13LkizOlA3KM7:TR?= M{f3SHNCVkeHUh?=
RVH-421 NF;KTnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHETWM2OD14LkC3N|M5KM7:TR?= M336PXNCVkeHUh?=
LB1047-RCC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fDfmlEPTB;Nj6xO|UzOiEQvF2= NWT0[ox7W0GQR1XS
MHH-NB-11 MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j3dGlEPTB;Nj6zNlczOSEQvF2= NUTXdIFyW0GQR1XS
J-RT3-T3-5 MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f6TmlEPTB;Nj62N|I6OSEQvF2= MX\TRW5ITVJ?
UM-UC-3 NWKzZZdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDwZ|RKSzVyPU[uOlQ{OzRizszN MVvTRW5ITVJ?
IST-SL1 NVHPdo91T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TVRmlEPTB;Nj62PVM3QSEQvF2= NXnKd|N3W0GQR1XS
NB14 NWrtS4NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS1cXBKSzVyPU[uO|k4PjFizszN MmfBV2FPT0WU
NBsusSR M{DtWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTZwOEK1NFIh|ryP MWXTRW5ITVJ?
D-263MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTZwOUGwOlgh|ryP M2LMVnNCVkeHUh?=
NCI-H2347 NWrqdFR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTZwOUOyNVMh|ryP NVvaenMxW0GQR1XS
ES8 NVr5cm1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXiTWM2OD14Lkm3OVg5KM7:TR?= MWHTRW5ITVJ?
786-0 NEHMUWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[5e4t4UUN3ME23MlA6Pzh4IN88US=> NI\ISpNUSU6JRWK=
EPLC-272H MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTdwMU[yOFYh|ryP MUHTRW5ITVJ?
CAPAN-1 MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXSTWM2OD15LkK0N|U6KM7:TR?= NXfIS2tOW0GQR1XS
NCI-H82 NX7DbJR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\Bb3pKSzVyPUeuNlY3PTlizszN NWD1T3RGW0GQR1XS
G-402 MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfibnJwUUN3ME23MlMxODVzIN88US=> NUiybIlEW0GQR1XS
SW982 NGP0UmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXvTWM2OD15LkOwNlA{KM7:TR?= NYLaeFlCW0GQR1XS
OVCAR-4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvjVI5JUUN3ME23MlMyOzJ6IN88US=> MWPTRW5ITVJ?
KARPAS-299 NFi4XXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e5WGlEPTB;Nz6zNlYzOiEQvF2= MXHTRW5ITVJ?
MIA-PaCa-2 M{nPfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTdwM{[4NlMh|ryP MXjTRW5ITVJ?
AU565 NHG5SG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH70[I1KSzVyPUeuOVk5OzNizszN NEnFPYtUSU6JRWK=
GAMG M3m3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfoboZKSzVyPUeuOlQyOzFizszN MmDrV2FPT0WU
HuO9 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn6N41nUUN3ME23MlcyPzR|IN88US=> M4XZTHNCVkeHUh?=
ACN MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHuTWM2OD15Lke0N|Mh|ryP NVTwNFY1W0GQR1XS
RO82-W-1 NF7GfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK1Z|hKSzVyPUeuO|Q2OzNizszN M2rlOnNCVkeHUh?=
NKM-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjkTWM2OD15Lke0PVU2KM7:TR?= MoHJV2FPT0WU
CAL-12T NFr5OnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPoTWM2OD15Lkm0N|UzKM7:TR?= MmjtV2FPT0WU
FADU MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRThwMEO2OVQh|ryP M2rKUXNCVkeHUh?=
NCI-H28 NFXXTlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPNZ|RWUUN3ME24MlE3QTZ{IN88US=> NF[zSIJUSU6JRWK=
LCLC-97TM1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRThwMkGxNlIh|ryP MX7TRW5ITVJ?
CHP-134 NFfYUlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXLRWxOUUN3ME24MlI1OTh3IN88US=> M{T5UnNCVkeHUh?=
HT-1080 Ml3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnToTWM2OD16LkK1NFk{KM7:TR?= MlrRV2FPT0WU
PC-3 M3WzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\rTWM2OD16LkK3N|kzKM7:TR?= MXzTRW5ITVJ?
SNU-449 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zVZ2lEPTB;OD6yO|k{KM7:TR?= M4\4PXNCVkeHUh?=
VA-ES-BJ NIDZS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRThwM{S2PFYh|ryP NHjYV2pUSU6JRWK=
HT MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTPTWM2OD16LkO2OFkh|ryP NGfYOFZUSU6JRWK=
HOS M3rJSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRThwM{e1PFkh|ryP MlvsV2FPT0WU
KNS-62 NIGyXWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRThwM{e3OlIh|ryP NHnyZ5BUSU6JRWK=
OAW-42 NIq5e3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHINFRKSzVyPUiuPVU6PjRizszN MX3TRW5ITVJ?
A549 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrRbGFPUUN3ME25MlA6PjF{IN88US=> M{[ycnNCVkeHUh?=
CAKI-1 NHnpPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW5TWM2OD17LkG2OlEh|ryP NXvPZmk3W0GQR1XS
HCC1937 NFL2bZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPLW3BMUUN3ME25MlY6QDZ3IN88US=> M3fMNnNCVkeHUh?=
GI-ME-N NEfRUpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTlwN{CxN|ch|ryP Mn3pV2FPT0WU
DU-4475 M1PrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LU[mlEPTB;OT65Olk{QSEQvF2= MVLTRW5ITVJ?
EM-2 NIj4[2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjlVHpKSzVyPUGwMlI1OjZizszN Mk\OV2FPT0WU
NCI-H1755 NH30S2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTFyLkK0Nlgh|ryP NFHGTlFUSU6JRWK=
NCI-H1437 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonLTWM2OD1zMD61O|I2KM7:TR?= MWTTRW5ITVJ?
VM-CUB-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXWXGhJUUN3ME2xNE43OTZ2IN88US=> M3j3fHNCVkeHUh?=
A2058 MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TUZ2lEPTB;MUCuOlQxPCEQvF2= NUjTXYhlW0GQR1XS
BPH-1 M3fINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXPVo9MUUN3ME2xNE44OTR3IN88US=> MVLTRW5ITVJ?
NB5 Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jDXmlEPTB;MUCuO|U2QSEQvF2= MorxV2FPT0WU
G-401 NVLKTJpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFyLke2NlYh|ryP MonWV2FPT0WU
CAL-72 NYXZb|VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTFyLkiwPVQh|ryP NGPzTXZUSU6JRWK=
SK-MEL-28 NW\mdZVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTFyLkiyNFIh|ryP NEfj[YdUSU6JRWK=
C32 NED4ZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf1Z3hVUUN3ME2xNE45OzR5IN88US=> NGrqZVhUSU6JRWK=
NCI-H1155 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XrSmlEPTB;MUCuPFM4PiEQvF2= M1nGXHNCVkeHUh?=
BB49-HNC MlfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jSOGlEPTB;MUCuPFU5PiEQvF2= NXL0WZB3W0GQR1XS
GMS-10 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\XTWM2OD1zMD64PVcyKM7:TR?= MlPrV2FPT0WU
K5 MofsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TIbGlEPTB;MUCuPVA4OSEQvF2= M3P5[XNCVkeHUh?=
OS-RC-2 MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXyVnVoUUN3ME2xNU4xPTV7IN88US=> MoL3V2FPT0WU
HTC-C3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTFzLkC3NVQh|ryP MX\TRW5ITVJ?
LB996-RCC MnXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj2fo9KSzVyPUGxMlA4OjNizszN MmPmV2FPT0WU
NCI-H1563 M3LUWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr5TWM2OD1zMT6xNFEyKM7:TR?= MXLTRW5ITVJ?
CAL-54 NIDCS2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfxTWM2OD1zMT60PFEyKM7:TR?= M3zqWXNCVkeHUh?=
WM-115 NGDZ[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFzLk[4NlQh|ryP NETLZpdUSU6JRWK=
COLO-684 M1vWNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITVc3dKSzVyPUGxMlczPjdizszN M3TFWnNCVkeHUh?=
HOP-62 MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7GZ3JKSzVyPUGxMlc2ODhizszN M1rTfnNCVkeHUh?=
NCI-H650 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjlcHRKUUN3ME2xNU45QTZzIN88US=> NIPsNIRUSU6JRWK=
TE-11 M4mySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDGcndKSzVyPUGxMlk{OTVizszN NULDSIpOW0GQR1XS
COLO-679 M2jz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vXWmlEPTB;MUGuPVQ3KM7:TR?= NX75WZFjW0GQR1XS
FTC-133 NV;ZeVljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HuTGlEPTB;MUKuNFA4PiEQvF2= NFXLR5lUSU6JRWK=
D-283MED Ml\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG0dnZKSzVyPUGyMlA2PjlizszN MWXTRW5ITVJ?
SK-PN-DW MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF{LkG5NFIh|ryP Ml\sV2FPT0WU
BALL-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HISWlEPTB;MUKuNlY3OiEQvF2= MkfBV2FPT0WU
GT3TKB MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfzSVVKSzVyPUGyMlMxPzRizszN M1XpZ3NCVkeHUh?=
HOP-92 NXLVZ5FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XZb2lEPTB;MUKuOVI{OyEQvF2= NWf1UnRQW0GQR1XS
M14 NFHyWHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPUTWM2OD1zMz6wN|M2KM7:TR?= MYfTRW5ITVJ?
SKG-IIIa NF\jXoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH3TWM2OD1zMz6wOVU1KM7:TR?= NH\ac45USU6JRWK=
Becker NVnoeGJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTzRW9tUUN3ME2xN{4xPThizszN MV3TRW5ITVJ?
ES5 M4fXdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TEUmlEPTB;MUOuNVM2PiEQvF2= MWLTRW5ITVJ?
NCI-H2030 MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rTcWlEPTB;MUOuNlA3OiEQvF2= MmnxV2FPT0WU
SNU-423 NULWOXhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7CZY5KSzVyPUGzMlM5OSEQvF2= NVfZTnZQW0GQR1XS
CP50-MEL-B NXvEO|BWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPXNJRKUUN3ME2xN{43OjN{IN88US=> MXzTRW5ITVJ?
NCI-H1092 M3XXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLOTWM2OD1zMz63OFc2KM7:TR?= M4HUOXNCVkeHUh?=
8-MG-BA NGXDU4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFKye|BKSzVyPUGzMlc2OTNizszN NWHQfXNwW0GQR1XS
CAL-27 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\PXFJKSzVyPUG0MlA4OjdizszN MlHDV2FPT0WU
AGS M12wVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK2TWM2OD1zND6xN|E6KM7:TR?= M1L4TnNCVkeHUh?=
MZ2-MEL M{TwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfvRXBEUUN3ME2xOE4yPDh6IN88US=> M2W2b3NCVkeHUh?=
BFTC-909 NHvTOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVmxdItRUUN3ME2xOE42ODV3IN88US=> MXvTRW5ITVJ?
D-566MG NETSVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;wZ2lEPTB;MUSuO|cxPiEQvF2= M{W3OXNCVkeHUh?=
MZ7-mel NVHtSnlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2iybmlEPTB;MUWuNVA3PyEQvF2= MWHTRW5ITVJ?
TE-5 NYjMe283T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7sXpM5UUN3ME2xOU4zOzN|IN88US=> M4TqV3NCVkeHUh?=
647-V M3[wemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjlcpZkUUN3ME2xOU4zPzB3IN88US=> NV7I[nRrW0GQR1XS
DMS-114 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXtTWM2OD1zNT6zNlkyKM7:TR?= MWHTRW5ITVJ?
ME-180 M2rremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\TTWM2OD1zNT60O|g{KM7:TR?= NH3vcnNUSU6JRWK=
MS-1 M{TEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PaSGlEPTB;MUWuOVYzOyEQvF2= NULrcHJ7W0GQR1XS
NUGC-3 Mk\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XqPGlEPTB;MUWuOlI1PSEQvF2= M2LDSXNCVkeHUh?=
GB-1 M2POSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHoTWM2OD1zNT62OFM4KM7:TR?= MorRV2FPT0WU
LOXIMVI NFrHepZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe3TWM2OD1zNT64PVE6KM7:TR?= M1XUTnNCVkeHUh?=
NCI-H1304 NHvobotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzxfJVrUUN3ME2xOU45QTJ6IN88US=> MlrxV2FPT0WU
KURAMOCHI NEHmXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTF3Lkm3NUDPxE1? Ml70V2FPT0WU
SW1783 MlHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIW2N4JKSzVyPUG2MlA6QTNizszN Mm\EV2FPT0WU
EGI-1 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fqOmlEPTB;MU[uOVM3PSEQvF2= MmLBV2FPT0WU
KGN M1r4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr4TWM2OD1zNj61OVg3KM7:TR?= NEe1VVBUSU6JRWK=
PANC-03-27 NYraRZFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLOTWM2OD1zNj63OlYzKM7:TR?= NHTYXoZUSU6JRWK=
RH-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF4LkiyOUDPxE1? NYn2eIptW0GQR1XS
HT-1376 NVHCW3VsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1joTWlEPTB;MU[uPFQ1PiEQvF2= NVzPfIF6W0GQR1XS
ZR-75-30 NYP4OWpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTF4LkmzOlEh|ryP NFzFdXRUSU6JRWK=
TI-73 M{[yRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:4eHdKSzVyPUG2Mlk1ODhizszN NVq3Wmd{W0GQR1XS
TK10 M{S4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGwNG4yUUN3ME2xO{4xODd7IN88US=> NYDVNGhVW0GQR1XS
SW684 M2Xzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV34dHJZUUN3ME2xO{4xOTV2IN88US=> NFL2U3lUSU6JRWK=
RPMI-8866 Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvYNXlKSzVyPUG3MlA3QTlizszN NH7qOldUSU6JRWK=
LNCaP-Clone-FGC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LnSGlEPTB;MUeuOVIxOSEQvF2= Mn7aV2FPT0WU
NCI-H2291 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTF6LkSzOFUh|ryP NUXXZW9JW0GQR1XS
T47D NIHVV4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTwN2t3UUN3ME2xPE41QDhizszN NVSyTYUzW0GQR1XS
A204 NGLTc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPhc4tWUUN3ME2xPE42PDV{IN88US=> MnnuV2FPT0WU
HT-144 NV7xVlZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH4TWM2OD1zOD63OFI4KM7:TR?= MmntV2FPT0WU
MDA-MB-361 Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTF7LkC3NVQh|ryP MWfTRW5ITVJ?
HCC1806 MlTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXKyUHk2UUN3ME2xPU4yPTlzIN88US=> MVjTRW5ITVJ?
NCI-H596 NGnTPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHHTWM2OD1zOT62N|kyKM7:TR?= NIfJbHpUSU6JRWK=
K-562 MofpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYOxUmh5UUN3ME2xPU45QTJ4IN88US=> NXjwRWtHW0GQR1XS
D-336MG MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF7LkmzNlIh|ryP MkfJV2FPT0WU
SK-MEL-2 NVz0VFI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfVTWM2OD1{MD6xOVU6KM7:TR?= NUixXJVvW0GQR1XS
HEC-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPITWM2OD1{MD60PVc5KM7:TR?= NELGXXNUSU6JRWK=
EW-13 M37RXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi5TWM2OD1{MD61OFQ{KM7:TR?= MYPTRW5ITVJ?
Hs-578-T NWnrZoVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3izO2lEPTB;MkCuOVU5OyEQvF2= NHTFPWVUSU6JRWK=
SJSA-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn2OIJKSzVyPUKwMlU3QDhizszN MkLhV2FPT0WU
RCC10RGB MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXDWYJNUUN3ME2yNE43PzF7IN88US=> NF\LRZZUSU6JRWK=
LAN-6 MkLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPSO|F[UUN3ME2yNU4xOzl4IN88US=> M{LsSXNCVkeHUh?=
NCI-H1048 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L5c2lEPTB;MkGuNlI2QCEQvF2= MlP5V2FPT0WU
CW-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vhfmlEPTB;MkGuNlcxPSEQvF2= NHTsNm1USU6JRWK=
HCC2157 M37jfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJzLkO2JO69VQ>? MknNV2FPT0WU
EW-22 M{S3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL1TWM2OD1{MT6zO|Yh|ryP MXPTRW5ITVJ?
A253 NVm2VnRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXESWtKSzVyPUKxMlQ1QDFizszN MlvpV2FPT0WU
BE-13 NHjre5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILPPGZKSzVyPUKxMlYyOTNizszN NVrmRolIW0GQR1XS
KINGS-1 M{HSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvrRpNKSzVyPUKxMlY{OTZizszN MnLRV2FPT0WU
ETK-1 M3zSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJzLkixOVIh|ryP MVfTRW5ITVJ?
NCI-H2452 M3S4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;LfJhKSzVyPUKxMlg3PDdizszN NX\2VGx{W0GQR1XS
HPAF-II NWG5SZc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKzN5BKSzVyPUKxMlg6OjNizszN NHXQOGRUSU6JRWK=
D-542MG M3HTb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJzLkmwOlkh|ryP MX7TRW5ITVJ?
NCI-H630 NELBTGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXVTWM2OD1{Mj6wNlk3KM7:TR?= M2nrSHNCVkeHUh?=
TGBC11TKB MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrwWJpKSzVyPUKyMlA1QSEQvF2= MkG4V2FPT0WU
BCPAP MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHmTWM2OD1{Mj62NVEh|ryP NWDBcXdqW0GQR1XS
HLE MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJ{Lk[5O{DPxE1? NIq1[VdUSU6JRWK=
NCI-H727 NHLLS3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlftTWM2OD1{Mj63N|Uh|ryP NULRZoMxW0GQR1XS
RD NILWVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPHTXkxUUN3ME2yNk44PTF6IN88US=> MUPTRW5ITVJ?
NCI-H522 M2Di[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S1VmlEPTB;MkKuPFQ{OSEQvF2= MWjTRW5ITVJ?
CGTH-W-1 NHL1TIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTJ|LkC2OFEh|ryP MoG3V2FPT0WU
SK-LU-1 NYXiN4NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLTTWM2OD1{Mz60Olg{KM7:TR?= MVfTRW5ITVJ?
BB65-RCC M1PmO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLUe4xKSzVyPUKzMlc5PjNizszN Mn\FV2FPT0WU
HSC-3 NWG1Z4s4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJ|Lki1Nlch|ryP NITq[4ZUSU6JRWK=
SK-MES-1 NUT3V3ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W5XWlEPTB;MkSuNFE3OSEQvF2= MnHtV2FPT0WU
DB Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HhbWlEPTB;MkSuNVAzQCEQvF2= MVjTRW5ITVJ?
HO-1-N-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2js[GlEPTB;MkSuN|A6OyEQvF2= M4rKO3NCVkeHUh?=
MKN1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjU[VVKSzVyPUK0MlY5KM7:TR?= NEnifHpUSU6JRWK=
MN-60 NXLPeVdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1G3e2lEPTB;MkSuPFUyQSEQvF2= NHP5UWFUSU6JRWK=
8505C MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX2ZnBKSzVyPUK1MlE5PDVizszN MX;TRW5ITVJ?
COLO-320-HSR MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJ3LkKyNFgh|ryP NHrNeVdUSU6JRWK=
BB30-HNC M1XQXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzhcGxKSzVyPUK1MlI1QDNizszN NHrEc3NUSU6JRWK=
KM12 NY\TbGtlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH5Rm02UUN3ME2yOU42QDB5IN88US=> M3fXPHNCVkeHUh?=
NB13 NFvme3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknhTWM2OD1{NT61PFk5KM7:TR?= M3zWbXNCVkeHUh?=
HCC2998 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJ4LkCyPFMh|ryP NGXMdIhUSU6JRWK=
U-118-MG NGnje4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXhd4RKSzVyPUK2MlA5ODhizszN MV;TRW5ITVJ?
NB10 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJ4LkKzOEDPxE1? NX36[IFOW0GQR1XS
SK-LMS-1 NILIVVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfFTWM2OD1{Nz6wO|A1KM7:TR?= MkDsV2FPT0WU
SW1573 NI\3SZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n4[GlEPTB;MkeuNVEh|ryP NF7i[4xUSU6JRWK=
LB373-MEL-D MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fke2lEPTB;MkeuNVI6PCEQvF2= MoDrV2FPT0WU
DK-MG MnnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PVTWlEPTB;MkeuNVgyPyEQvF2= NGrOdlVUSU6JRWK=
RMG-I MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHmTWM2OD1{Nz6yNFI6KM7:TR?= Ml\uV2FPT0WU
SW1088 M{nTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD6TWM2OD1{Nz61NFQzKM7:TR?= Ml;qV2FPT0WU
SK-OV-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGniS|ZKSzVyPUK3Mlc2QTNizszN NEXVS|NUSU6JRWK=
KP-N-YN MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XZemlEPTB;MkeuPFA1OyEQvF2= MWDTRW5ITVJ?
RPMI-7951 NHrYNFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv0SnNKSzVyPUK4MlI1PTZizszN MkWwV2FPT0WU
CaR-1 NWLkSndWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLGTWM2OD1{OD61OVgzKM7:TR?= NIn4TW1USU6JRWK=
MKN7 M2ixVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjNRmdKSzVyPUK4MlU6PjRizszN M1nKSnNCVkeHUh?=
CHP-212 M3rRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fI[GlEPTB;MkiuO|QxOSEQvF2= M3u4OnNCVkeHUh?=
KYSE-450 M{PoS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjDW4xKSzVyPUK4MlgxQTFizszN NUTzeYp6W0GQR1XS
RXF393 M{\lRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13CW2lEPTB;MkmuNlkxPiEQvF2= NX23XHhtW0GQR1XS
P30-OHK NFHjPHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHzOYxKSzVyPUK5MlMxPDhizszN MmLyV2FPT0WU
Ca9-22 MnvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXZdJhKSzVyPUK5MlQzQTlizszN NE\lT|lUSU6JRWK=
RT-112 M2rsTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M32yUWlEPTB;MkmuOFYyOSEQvF2= NXTB[oR{W0GQR1XS
ES1 NIDUb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTJ7Lki1OFQh|ryP NUfUfFZjW0GQR1XS
HCE-4 NG\xbJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJ7Lki3PFYh|ryP M{GzVXNCVkeHUh?=
AM-38 M{HvfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4js[GlEPTB;M{CuNFYxPiEQvF2= MV7TRW5ITVJ?
AsPC-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D0TGlEPTB;M{CuPFA2OyEQvF2= MoT0V2FPT0WU
TE-9 MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFm3UVRKSzVyPUOwMlg4OzdizszN NFvzN|ZUSU6JRWK=
HuP-T4 Ml\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljQTWM2OD1|MD65OlM5KM7:TR?= MXHTRW5ITVJ?
LB2518-MEL M1;Temdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW5TWM2OD1|MT6wO|Q1KM7:TR?= M1rDNHNCVkeHUh?=
NCI-H1703 M4SyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWKxbWtsUUN3ME2zNU4xQTB3IN88US=> Ml7iV2FPT0WU
NCI-H2228 NF;iV4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HnOWlEPTB;M{GuOFY2OSEQvF2= NFn0Z2dUSU6JRWK=
SCC-4 NED3TVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC0TWM2OD1|MT65NVgyKM7:TR?= MVTTRW5ITVJ?
KNS-81-FD NIfYXlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnCfW5KSzVyPUOyMlAyOjhizszN NX7FOYZIW0GQR1XS
NTERA-S-cl-D1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Pq[2lEPTB;M{KuNFc{QSEQvF2= MVPTRW5ITVJ?
Daoy NU\1b3djT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTN{LkC4N|gh|ryP Mlv4V2FPT0WU
ES4 M37tVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq1TWM2OD1|Mj6zPVIzKM7:TR?= MmPwV2FPT0WU
MHH-ES-1 NFzu[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTN{LkS4O|Ih|ryP MWXTRW5ITVJ?
C-33-A MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DORmlEPTB;M{KuO|czQCEQvF2= NUe4XYxyW0GQR1XS
BHY MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTN{Lkm0PVUh|ryP M33iRXNCVkeHUh?=
Detroit562 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET1dnJKSzVyPUOzMlY3PTdizszN MoG1V2FPT0WU
EW-1 NFTZO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13vd2lEPTB;M{OuPVMzOiEQvF2= NFrtNZRUSU6JRWK=
NCI-H1395 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vMWGlEPTB;M{SuNFc6QSEQvF2= NFS4ZW1USU6JRWK=
KM-H2 NEfsdHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3CTWM2OD1|Nj60O|Q{KM7:TR?= M3nucHNCVkeHUh?=
NCI-H520 Mk\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe3WYQ1UUN3ME2zOk44PTRzIN88US=> NHK3dXFUSU6JRWK=
D-392MG MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\McGlEPTB;M{euN|M1PCEQvF2= MofhV2FPT0WU
NOMO-1 NH7JRVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO2Z|ZKSzVyPUO3MlgxQDlizszN M1jRZ3NCVkeHUh?=
TE-6 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmC2TWM2OD1|OD6xNlQh|ryP NHn3bm5USU6JRWK=
HT-3 NHLuNJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDZXYM2UUN3ME2zPE41PDN4IN88US=> M4nld3NCVkeHUh?=
RPMI-8226 NFTZOW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHTTWM2OD1|OD65OVE6KM7:TR?= NVrpcZhJW0GQR1XS
U251 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfBTWM2OD1|OT6wNVI1KM7:TR?= M{HxPXNCVkeHUh?=
GCT NFvsNppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUKyUodDUUN3ME2zPU4yQDV{IN88US=> M{DhTnNCVkeHUh?=
A431 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;NUGlEPTB;M{muNVg6PCEQvF2= MVvTRW5ITVJ?
TE-12 M3vJemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTN7LkK0OFgh|ryP M3ro[HNCVkeHUh?=
HMV-II MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTN7LkWwOFch|ryP NVrXXoQyW0GQR1XS
IST-MES1 M3TaRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PneGlEPTB;NECuNVUxOiEQvF2= MlLCV2FPT0WU
SW13 NF3ybWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDNTWM2OD12MD61NVkh|ryP MXrTRW5ITVJ?
SF295 MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTlWY9KSzVyPUSwMlgxPjZizszN NUO3XYhkW0GQR1XS
MDA-MB-157 MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly4TWM2OD12MD65OFYzKM7:TR?= NWnR[Ix{W0GQR1XS
TE-1 Mn\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLnTWM2OD12MT64O|E1KM7:TR?= MoD1V2FPT0WU
HuCCT1 NYXZT2Q4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MormTWM2OD12Mj61Nlg6KM7:TR?= NXXkSWduW0GQR1XS
KYSE-510 NWjE[GhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjIdFZKSzVyPUSzMlE4PTRizszN NX;wS3hzW0GQR1XS
NCI-H358 NHS3W3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LWW2lEPTB;NESuNFMxPCEQvF2= Mm\tV2FPT0WU
SW900 M{[2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTR2LkC3OVgh|ryP MonDV2FPT0WU
CAS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PyXGlEPTB;NESuNFk6OSEQvF2= M{HYdnNCVkeHUh?=
TE-8 M2PCUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTR2LkW2OVgh|ryP MkiwV2FPT0WU
P12-ICHIKAWA M1TESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTR2Lk[xNVIh|ryP NU\hU3RVW0GQR1XS
YKG-1 NGXmXYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTR2Lke4NUDPxE1? M4X4VnNCVkeHUh?=
SNU-C2B MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjqTWM2OD12ND63PVA{KM7:TR?= NGL5UIdUSU6JRWK=
LCLC-103H M1rBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3HT4dKSzVyPUS0Mlg4ODNizszN MXzTRW5ITVJ?
U-87-MG M2XRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\wTWM2OD12NT6xNFIzKM7:TR?= M3rkcHNCVkeHUh?=
HAL-01 MkXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP6T|ZKSzVyPUS1MlE{PzlizszN MlT3V2FPT0WU
OVCAR-8 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKzdGlKUUN3ME20OU4{PTZ2IN88US=> NF7WWZdUSU6JRWK=
KYSE-150 NWHQW4JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWr4eG86UUN3ME20O{4yODV{IN88US=> NH30bo5USU6JRWK=
OE33 NVexTFA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHZSnVKSzVyPUS3MlE1OjlizszN MXLTRW5ITVJ?
CAL-62 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmm4TWM2OD12Nz60NFY5KM7:TR?= MUHTRW5ITVJ?
TCCSUP MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7KVo5wUUN3ME20O{43OjZ2IN88US=> NX\yNIF2W0GQR1XS
H4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LpTmlEPTB;NEeuOlYzOSEQvF2= M1fN[nNCVkeHUh?=
CP66-MEL NUe1Z|ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTR6LkC3NFQh|ryP MlLtV2FPT0WU
SNB75 NYruXFlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\4[HFKSzVyPUS4MlE5PzRizszN NI\RW2xUSU6JRWK=
Mo-T MoTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LEUWlEPTB;NEiuNlc6KM7:TR?= NYjwdYY6W0GQR1XS
BT-549 M{XCcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fwSGlEPTB;NEiuN|czQSEQvF2= MWHTRW5ITVJ?
IGR-1 NFHJO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TDcGlEPTB;NEiuOlY1PSEQvF2= MVzTRW5ITVJ?
NCI-H1299 M3SwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTR6LkeyOFgh|ryP MkHuV2FPT0WU
ALL-PO MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHxc2xKSzVyPUS5MlkzPjhizszN M1nkXHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]
臨床試験
特集

プロトコル (参考用のみ)

細胞アッセイ: [2]

細胞株 SW620, LoVo, V3-YAC and V3 cells
濃度 0.5 μM or 1 μM
反応時間 17 hours
実験の流れ The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.

動物実験: [2]

動物モデル Female rude mice bearing SW620 xenografts
製剤 Sterile 0.9% sodium chloride solution
投薬量 10 mg/kg
投与方法 Intraperitoneally administrated

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download NU7441 (KU-57788) SDF
分子量 413.49
化学式

C25H19NO3S

CAS No. 503468-95-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 3 mg/mL (7.25 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

カスタマーフィードバック (4)


Click to enlarge
Rating
Source Nucleic Acids Res, 2013, 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck
Method EU Immunofluorescence
Cell Lines A2780 ovarian cancer cells
Concentrations 1 uM
Incubation Time 1 h
Results It performed similar experiments using specific inhibitors of DNA-PK. Treatment with Nu7026 or Nu7441 before cisplatin significantly prevented inhibition of rRNA synthesis.

Click to enlarge
Rating
Source Nucleic Acids Res, 2013, 41, 10157-69. NU7441 (KU-57788) purchased from Selleck
Method Confocal immunostaining
Cell Lines 293T
Concentrations
Incubation Time 30min ,60min
Results the number of IRIFs was reduced significantly in p18CycE-expressing HEK 293T cells compared with parental cells. Pharmacological inhibition of ATM with KU55933 Revealed that S25-53BP1 phosphorylation was ATM-dependent in these cells as IRIFs of S25-53BP1 were abolished in both parental, as well as p18CycE-expressing cells.

Click to enlarge
Rating
Source Toxicol Sci, 2014, 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck
Method Western blot
Cell Lines H460 cells
Concentrations 1, 3, 10 uM
Incubation Time 1 h
Results It tested 3 concentrations of 2 DNAPK inhibitors (NU7026 and NU7441) for their off-target effects on ATM and ATR signaling in camptothecin-exposed cells. We found that only the highest dose of 60 uM NU7026 clearly diminished ATR activity as evidenced by a lower CHK1 phosphorylation. All doses of both inhibitors eliminated activating autophosphorylation of DNAPK at Ser2056.

Click to enlarge
Rating
Source Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck
Method
Cell Lines A549 cells
Concentrations 0-10 μM
Incubation Time 3 h
Results NU-7441 treatment resulted in a reduction of AKT phosphorylation.

文献中の引用 (15)

Frequently Asked Questions

  • Question 1
    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

    Answer: Slight color variation due to different processing is normal and usually doesn't interfere with the function.

技術サポート&よくある質問(FAQ)

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    CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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