NU7441 (KU-57788) 化学構造
分子量: 413.49

高品質保証

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Quality Control & MSDS

製品説明

  • Compare DNA-PK Inhibitors
    DNA-PK製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 NU7441 (KU-57788)は、14nMのIC50による非常に強力で選択的なDNAPK阻害剤です。
ターゲット DNA-PK
IC50 14 nM [1]
In vitro試験 NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H1770 NFTnVVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO2TWM2OD1yLkCyNVQ{KM7:TR?= NEDiXFhUSU6JRWK=
A172 M1LJWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3ZbpdPUUN3ME2wMlE2OzF4IN88US=> MkPYV2FPT0WU
NCI-H526 NX;LWpJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMki0NFch|ryP M{LQ[3NCVkeHUh?=
HDLM-2 NF3wcHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHJeolyUUN3ME2wMlMzOzR3IN88US=> M4Lab3NCVkeHUh?=
HuO-3N1 NGXSOlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInrWWtKSzVyPUCuOFY3OzZizszN NITUeVdUSU6JRWK=
NCI-SNU-1 M4\Obmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfhS205UUN3ME2wMlYxQTl2IN88US=> NUS5VVlsW0GQR1XS
SK-N-AS NF\mNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwNkKyNVYh|ryP M3;yXXNCVkeHUh?=
LoVo MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTKfpVKSzVyPUCuPFY4PDlizszN NXvrUVVwW0GQR1XS
LAMA-84 M3PsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnsNVZEUUN3ME2wMlk5QDN|IN88US=> M3XvWnNCVkeHUh?=
CTB-1 M4LkT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTFwMUG1OFYh|ryP NVX4XXVMW0GQR1XS
KP-N-YS NF\HdIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYS2UllnUUN3ME2xMlE1OjNzIN88US=> NHTsPIlUSU6JRWK=
HH MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vyeGlEPTB;MT6xPFA6OyEQvF2= M1j4bnNCVkeHUh?=
CHL-1 NFnCfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPOe2VKSzVyPUGuNlE{PjhizszN MWDTRW5ITVJ?
NB7 NFO2O2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LTNmlEPTB;MT6yOFc1PSEQvF2= M{T6O3NCVkeHUh?=
HL-60 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTFwM{ixPUDPxE1? Mn3JV2FPT0WU
639-V NHGyTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXuycG1SUUN3ME2xMlQ1OTJ6IN88US=> MnjWV2FPT0WU
NCI-H1793 NFL6fWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFwNEW4OEDPxE1? NVz4TotJW0GQR1XS
NEC8 NFOxZlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ftbWlEPTB;MT61OVM2KM7:TR?= M4HJeHNCVkeHUh?=
PA-1 MkjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTFwNUiyPVQh|ryP MXrTRW5ITVJ?
D-423MG NGTt[nhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP5TWM2OD1zLk[5N|YyKM7:TR?= NYLWdXRoW0GQR1XS
NCI-H292 NVLBSWxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XYcGlEPTB;MT63OFAyOyEQvF2= MXfTRW5ITVJ?
SK-MEL-1 NGizToJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX73Olk{UUN3ME2xMlc6PDd7IN88US=> NULnOppPW0GQR1XS
LB2241-RCC M{O5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Sz[mlEPTB;Mj6xOFE1PiEQvF2= NXXWUZFNW0GQR1XS
SK-MEL-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJwMU[0PUDPxE1? MXvTRW5ITVJ?
MHH-PREB-1 NV[zWWtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7QdWZbUUN3ME2yMlE3PjB7IN88US=> M2HHT3NCVkeHUh?=
BFTC-905 NILoXYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJwMU[2PFch|ryP MYrTRW5ITVJ?
Ramos-2G6-4C10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJwMUm5NFkh|ryP MVLTRW5ITVJ?
G-361 NV\XVJlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojmTWM2OD1{LkKxOlgh|ryP NIK4WW9USU6JRWK=
MOLT-4 NX23WWxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[zV4xKSzVyPUKuNlE5QDhizszN NV2xfWRMW0GQR1XS
DEL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XvVGlEPTB;Mj6zOVU3PCEQvF2= MV\TRW5ITVJ?
MV-4-11 MmW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfkRWNKSzVyPUKuN|c{QSEQvF2= MYnTRW5ITVJ?
SK-NEP-1 MkPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\UTWM2OD1{LkO4O|g{KM7:TR?= MXrTRW5ITVJ?
RS4-11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3JTWM2OD1{LkW2NFI{KM7:TR?= NW\hOlg1W0GQR1XS
HuH-7 M1mxTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\5e3ZKSzVyPUKuOVY4ODJizszN NXnIT45bW0GQR1XS
A101D Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrtTWM2OD1{Lk[xN|M5KM7:TR?= MVrTRW5ITVJ?
KG-1 M2O1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HmRWlEPTB;Mj62O|kzPCEQvF2= MV7TRW5ITVJ?
KALS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj1cXBJUUN3ME2yMlY6PjN|IN88US=> M3zo[HNCVkeHUh?=
VMRC-RCZ M2TRRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLBTWM2OD1{Lke3N|I5KM7:TR?= MlLBV2FPT0WU
SK-UT-1 M3\HNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPLNJNJUUN3ME2zMlE2OzFizszN NUf3TotCW0GQR1XS
SW962 Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTNwMkCzOVIh|ryP NIjie2pUSU6JRWK=
DBTRG-05MG MkLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorFTWM2OD1|LkK4NFg2KM7:TR?= M3XmfnNCVkeHUh?=
PANC-08-13 M4LobWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jydWlEPTB;Mz60NVI4QCEQvF2= NEj1[3BUSU6JRWK=
QIMR-WIL NFXTOHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXz6Z|J{UUN3ME2zMlQyOzRzIN88US=> NYjQcotXW0GQR1XS
SK-MEL-30 M1vJfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVizb5pGUUN3ME2zMlQzPTl6IN88US=> M4r3U3NCVkeHUh?=
697 M2PSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4m5d2lEPTB;Mz60OFk6OyEQvF2= MoXjV2FPT0WU
NY MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfjbWNKSzVyPUOuOFUxOjJizszN MUjTRW5ITVJ?
ES7 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\GNotKSzVyPUOuOFY4OjlizszN MkDCV2FPT0WU
JVM-3 M2nTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zKU2lEPTB;Mz60PFA4PyEQvF2= MoewV2FPT0WU
U031 NIf3N25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjyNYFKSzVyPUOuOVk{PjhizszN Ml24V2FPT0WU
BHT-101 M1PWemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnRSotXUUN3ME2zMlU6QTh3IN88US=> NIrmZ4NUSU6JRWK=
8305C NI\ZeY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T2RWlEPTB;Mz62NVc{PiEQvF2= NH3Db|RUSU6JRWK=
MG-63 NHjuZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTNwNkK2O|Yh|ryP NYnmNIQxW0GQR1XS
NOS-1 NYLoXFNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvnelQ5UUN3ME2zMlY2OzF{IN88US=> NHXKeIZUSU6JRWK=
YH-13 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnI[4RKSzVyPUOuPFcyQDlizszN NUn6T5BsW0GQR1XS
LXF-289 M1;KOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTNwOUGwOFEh|ryP MWTTRW5ITVJ?
GOTO M1;sZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TEc2lEPTB;Mz65NVQ6KM7:TR?= MV;TRW5ITVJ?
EKVX MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT5TWM2OD12LkKyOVI1KM7:TR?= MmTOV2FPT0WU
CAL-51 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXLTWM2OD12LkK0PFU1KM7:TR?= NELIcZRUSU6JRWK=
AN3-CA NH7HeG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\jdGlEPTB;ND6yOVgyOyEQvF2= MkLHV2FPT0WU
IA-LM MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrkTWM2OD12LkK3PVM2KM7:TR?= MlLIV2FPT0WU
KU-19-19 M{LpOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWqyVZJtUUN3ME20MlMzQTJzIN88US=> M{LJeHNCVkeHUh?=
A704 NG\sTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjSNWtKSzVyPUSuOFA5QDhizszN Mn7MV2FPT0WU
RH-18 NYO0XZFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfFTWM2OD12LkS0PVU{KM7:TR?= NW\0UFU{W0GQR1XS
IST-MEL1 MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknPTWM2OD12LkW4NlY{KM7:TR?= NX\IRVRKW0GQR1XS
LU-134-A NX[wTGw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LpO2lEPTB;ND61PVY5PSEQvF2= Mnf4V2FPT0WU
SF126 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\vd4l4UUN3ME20MlYxPzF3IN88US=> NWrNXXl4W0GQR1XS
EFO-27 NVTSR3VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\vWWlEPTB;ND62OlUzPSEQvF2= M{X4[XNCVkeHUh?=
SN12C MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTRwN{G4PVgh|ryP MVrTRW5ITVJ?
L-363 NV7NPXpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fQVmlEPTB;ND63O|EyPiEQvF2= MnniV2FPT0WU
MEL-HO NFPwXndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK1[FdKSzVyPUSuO|c6QDlizszN NYSw[np2W0GQR1XS
TYK-nu MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrt[3hzUUN3ME20MlgxOTJ6IN88US=> MV7TRW5ITVJ?
MDA-MB-415 NWW5RnF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jqWGlEPTB;NT6wNFMyPCEQvF2= NVP5VlZJW0GQR1XS
HCC70 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvuTWM2OD13LkCzPVM6KM7:TR?= NXrNT3RCW0GQR1XS
IGROV-1 M2O3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYKwOGlFUUN3ME21MlI2Ojl{IN88US=> MUjTRW5ITVJ?
NCI-H1355 NH65dlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13CSGlEPTB;NT6yPVYh|ryP MXPTRW5ITVJ?
23132-87 NIf5copIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTVwM{KwNlQh|ryP MWLTRW5ITVJ?
NB69 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH62c5RKSzVyPUWuN|I1OiEQvF2= MXnTRW5ITVJ?
HSC-2 MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHhTWM2OD13LkSxO|c{KM7:TR?= M4Pw[3NCVkeHUh?=
KYSE-410 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vJNGlEPTB;NT60O|Y{PiEQvF2= NG\aclhUSU6JRWK=
GCIY NYCy[XVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfST3lsUUN3ME21MlUyOzd6IN88US=> MortV2FPT0WU
A427 NEfIUo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\iTGlEPTB;NT61N|Y3OSEQvF2= NYnHNVN[W0GQR1XS
ChaGo-K-1 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzCWGExUUN3ME21MlU3PTl7IN88US=> NIPjN4pUSU6JRWK=
PFSK-1 NWPvRphPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH64[lVKSzVyPUWuOlIyQTRizszN NU[3XHE2W0GQR1XS
MLMA M1zpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHITWM2OD13LkizOlA3KM7:TR?= MXHTRW5ITVJ?
RVH-421 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rXZWlEPTB;Nj6wO|M{QCEQvF2= NYTBS5JkW0GQR1XS
LB1047-RCC Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r4T2lEPTB;Nj6xO|UzOiEQvF2= M4LX[HNCVkeHUh?=
MHH-NB-11 Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW4TWM2OD14LkOyO|IyKM7:TR?= MV;TRW5ITVJ?
J-RT3-T3-5 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\BNZZMUUN3ME22MlY{OjlzIN88US=> M164SXNCVkeHUh?=
UM-UC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXRTWM2OD14Lk[0N|M1KM7:TR?= MVnTRW5ITVJ?
IST-SL1 NETKRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfBNGZHUUN3ME22MlY6OzZ7IN88US=> MUTTRW5ITVJ?
NB14 MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTZwN{m3OlEh|ryP NUDpSZJiW0GQR1XS
NBsusSR NYPicnpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LXe2lEPTB;Nj64NlUxOiEQvF2= MnHEV2FPT0WU
D-263MG M4jWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rreWlEPTB;Nj65NVA3QCEQvF2= MVnTRW5ITVJ?
NCI-H2347 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki0TWM2OD14LkmzNlE{KM7:TR?= M1fPSHNCVkeHUh?=
ES8 MorSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW3TWM2OD14Lkm3OVg5KM7:TR?= NYG5VZhOW0GQR1XS
786-0 M3ewWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm5UFhKSzVyPUeuNFk4QDZizszN NFWweVVUSU6JRWK=
EPLC-272H NGDmRnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjrd4xKSzVyPUeuNVYzPDZizszN MoDXV2FPT0WU
CAPAN-1 M3XhNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTdwMkSzOVkh|ryP M2Do[nNCVkeHUh?=
NCI-H82 M{P1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGiwTHhKSzVyPUeuNlY3PTlizszN MWjTRW5ITVJ?
G-402 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTte|NKSzVyPUeuN|AxPTFizszN Mn;lV2FPT0WU
SW982 NGTpRXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTdwM{CyNFMh|ryP NWj2RYNlW0GQR1XS
OVCAR-4 M3K0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnuTWM2OD15LkOxN|I5KM7:TR?= M2X0SnNCVkeHUh?=
KARPAS-299 MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[yTWM2OD15LkOyOlIzKM7:TR?= NIiyZpZUSU6JRWK=
MIA-PaCa-2 NEXGdXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DQNGlEPTB;Nz6zOlgzOyEQvF2= NHrPW|JUSU6JRWK=
AU565 NH3TbG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHZbm9KSzVyPUeuOVk5OzNizszN MXLTRW5ITVJ?
GAMG M1uxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;FW2lMUUN3ME23MlY1OTNzIN88US=> NWq4NYl3W0GQR1XS
HuO9 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPWTWM2OD15LkexO|Q{KM7:TR?= MmnpV2FPT0WU
ACN M{\temdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzxTZNKSzVyPUeuO|Q{OyEQvF2= MknFV2FPT0WU
RO82-W-1 M{ixWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXIcolKSzVyPUeuO|Q2OzNizszN NV;kZlhHW0GQR1XS
NKM-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTdwN{S5OVUh|ryP NGLs[2VUSU6JRWK=
CAL-12T MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\tSXBKSzVyPUeuPVQ{PTJizszN MlTnV2FPT0WU
FADU MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHGxXoZKSzVyPUiuNFM3PTRizszN M2jHSXNCVkeHUh?=
NCI-H28 NFPiUo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTmTWM2OD16LkG2PVYzKM7:TR?= NFHmOJZUSU6JRWK=
LCLC-97TM1 MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDCWmZKSzVyPUiuNlEyOjJizszN MVjTRW5ITVJ?
CHP-134 NYfDXVVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnJZZJmUUN3ME24MlI1OTh3IN88US=> M4fDcnNCVkeHUh?=
HT-1080 NGKzdZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRThwMkWwPVMh|ryP NHTFdmdUSU6JRWK=
PC-3 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHRRWhKSzVyPUiuNlc{QTJizszN M2fVRXNCVkeHUh?=
SNU-449 Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1u5TWlEPTB;OD6yO|k{KM7:TR?= MnflV2FPT0WU
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HT NHvyeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFSyT3VKSzVyPUiuN|Y1QSEQvF2= NULJVoZuW0GQR1XS
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OAW-42 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LCfWlEPTB;OD65OVk3PCEQvF2= M{XFNXNCVkeHUh?=
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CAKI-1 NGDGW2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEWxS2RKSzVyPUmuNVY3OSEQvF2= M2rae3NCVkeHUh?=
HCC1937 NES3TZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTlwNkm4OlUh|ryP MWXTRW5ITVJ?
GI-ME-N NH[1OGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LwOmlEPTB;OT63NFE{PyEQvF2= MX7TRW5ITVJ?
DU-4475 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTlwOU[5N|kh|ryP NGPMd2xUSU6JRWK=
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NCI-H1755 NVPld5BQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFyLkK0Nlgh|ryP MoXmV2FPT0WU
NCI-H1437 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PpfWlEPTB;MUCuOVczPSEQvF2= M2X2TnNCVkeHUh?=
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A2058 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6xNXRKSzVyPUGwMlY1ODRizszN MoHPV2FPT0WU
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G-401 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LHfWlEPTB;MUCuO|YzPiEQvF2= NEfq[5FUSU6JRWK=
CAL-72 M2HrUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3SWJVKSzVyPUGwMlgxQTRizszN MV7TRW5ITVJ?
SK-MEL-28 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnFR3B3UUN3ME2xNE45OjB{IN88US=> MXTTRW5ITVJ?
C32 NWjxfG1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr5dopwUUN3ME2xNE45OzR5IN88US=> MXnTRW5ITVJ?
NCI-H1155 NUj5fo9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mweWlEPTB;MUCuPFM4PiEQvF2= MXzTRW5ITVJ?
BB49-HNC NH7GSXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zESmlEPTB;MUCuPFU5PiEQvF2= NGfVfopUSU6JRWK=
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K5 M1zVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi3NYpWUUN3ME2xNE46ODdzIN88US=> MX3TRW5ITVJ?
OS-RC-2 NHvScplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjTTWM2OD1zMT6wOVU6KM7:TR?= MnHYV2FPT0WU
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LB996-RCC NHLlU|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFzLkC3NlMh|ryP MVvTRW5ITVJ?
NCI-H1563 NXLuT4M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTFzLkGwNVEh|ryP MXzTRW5ITVJ?
CAL-54 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDjTWM2OD1zMT60PFEyKM7:TR?= NVSyTW1zW0GQR1XS
WM-115 M3LEUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTFzLk[4NlQh|ryP M3TUfnNCVkeHUh?=
COLO-684 NXThO49NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTFzLkeyOlch|ryP NYq2c5JNW0GQR1XS
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NCI-H650 M{PidGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HQbGlEPTB;MUGuPFk3OSEQvF2= NHm3cIJUSU6JRWK=
TE-11 NF3uTopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXDXlN3UUN3ME2xNU46OzF3IN88US=> M13odnNCVkeHUh?=
COLO-679 M{\aTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHB[m9oUUN3ME2xNU46PDZizszN NVfOSmVKW0GQR1XS
FTC-133 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrDcGdKSzVyPUGyMlAxPzZizszN Mn7NV2FPT0WU
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SK-PN-DW M{nZO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL2TWM2OD1zMj6xPVAzKM7:TR?= M2DVXHNCVkeHUh?=
BALL-1 M3X1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[5VGVKSzVyPUGyMlI3PjJizszN NYT0fJo{W0GQR1XS
GT3TKB M{HpU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HBfWlEPTB;MUKuN|A4PCEQvF2= Mkf3V2FPT0WU
HOP-92 NWeyc2F{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M376[GlEPTB;MUKuOVI{OyEQvF2= MlXWV2FPT0WU
M14 MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF|LkCzN|Uh|ryP NWHCPJNiW0GQR1XS
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Becker M1Tw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:1cYVDUUN3ME2xN{4xPThizszN M3GwNXNCVkeHUh?=
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NCI-H2030 M3nzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\rOFBCUUN3ME2xN{4zODZ{IN88US=> NFu5O41USU6JRWK=
SNU-423 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:zOVJKSzVyPUGzMlM5OSEQvF2= MV3TRW5ITVJ?
CP50-MEL-B MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF|Lk[yN|Ih|ryP MVTTRW5ITVJ?
NCI-H1092 NXGzTWtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF|Lke0O|Uh|ryP NILRT5dUSU6JRWK=
8-MG-BA MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7jTWM2OD1zMz63OVE{KM7:TR?= MVTTRW5ITVJ?
CAL-27 NF7QO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfxc5pKSzVyPUG0MlA4OjdizszN MWPTRW5ITVJ?
AGS MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPqUYpPUUN3ME2xOE4yOzF7IN88US=> MXnTRW5ITVJ?
MZ2-MEL MmPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;3TWM2OD1zND6xOFg5KM7:TR?= NWjl[XRHW0GQR1XS
BFTC-909 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLMTWM2OD1zND61NFU2KM7:TR?= NFLpWGdUSU6JRWK=
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MZ7-mel NFvweXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnSXWZ[UUN3ME2xOU4yODZ5IN88US=> M2P4S3NCVkeHUh?=
TE-5 M1nMPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHoN3V4UUN3ME2xOU4zOzN|IN88US=> NYDUc2l3W0GQR1XS
647-V NW\uO29WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXJd5V[UUN3ME2xOU4zPzB3IN88US=> MVHTRW5ITVJ?
DMS-114 M{DQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF3LkOyPVEh|ryP NWTFZoptW0GQR1XS
ME-180 NGnpZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;MVmduUUN3ME2xOU41Pzh|IN88US=> MkXoV2FPT0WU
MS-1 NHHIT3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnEOYVKSzVyPUG1MlU3OjNizszN MmPKV2FPT0WU
NUGC-3 NXHzR4VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonhTWM2OD1zNT62NlQ2KM7:TR?= M3K3b3NCVkeHUh?=
GB-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTyVoVKSzVyPUG1MlY1OzdizszN M2rBeXNCVkeHUh?=
LOXIMVI NY\KO49tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF3Lki5NVkh|ryP NYG1OnlrW0GQR1XS
NCI-H1304 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TLN2lEPTB;MUWuPFkzQCEQvF2= M{PydHNCVkeHUh?=
KURAMOCHI NFfa[FZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHYcHV1UUN3ME2xOU46PzFizszN NWjhW2szW0GQR1XS
SW1783 M1HwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrFXXhLUUN3ME2xOk4xQTl|IN88US=> M4TOZXNCVkeHUh?=
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PANC-03-27 M4fR[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTF4Lke2OlIh|ryP NVPxTW9DW0GQR1XS
RH-1 NF;YR5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX2ze5JWUUN3ME2xOk45OjVizszN MXPTRW5ITVJ?
HT-1376 NUfLeHNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLOTWM2OD1zNj64OFQ3KM7:TR?= M3;XdnNCVkeHUh?=
ZR-75-30 NFHVXoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF4LkmzOlEh|ryP NVe2b25OW0GQR1XS
TI-73 NXnid3prT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoD5TWM2OD1zNj65OFA5KM7:TR?= M{G2c3NCVkeHUh?=
TK10 MnPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm0Z2xKSzVyPUG3MlAxPzlizszN MnLGV2FPT0WU
SW684 NFe3eXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF5LkCxOVQh|ryP NITienZUSU6JRWK=
RPMI-8866 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;ISmFUUUN3ME2xO{4xPjl7IN88US=> MUHTRW5ITVJ?
LNCaP-Clone-FGC M3vkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF5LkWyNFEh|ryP MkeyV2FPT0WU
NCI-H2291 M1rFNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTF6LkSzOFUh|ryP MV\TRW5ITVJ?
T47D MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvxTWM2OD1zOD60PFgh|ryP MWrTRW5ITVJ?
A204 M1\rWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYewRppDUUN3ME2xPE42PDV{IN88US=> M2S5TXNCVkeHUh?=
HT-144 NUPQOpdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[zVXJ5UUN3ME2xPE44PDJ5IN88US=> MoXlV2FPT0WU
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NCI-H596 MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;xcmR4UUN3ME2xPU43OzlzIN88US=> NHywOm9USU6JRWK=
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D-336MG MkTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF7LkmzNlIh|ryP MnzPV2FPT0WU
SK-MEL-2 M1ewZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7NTWM2OD1{MD6xOVU6KM7:TR?= MYnTRW5ITVJ?
HEC-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJyLkS5O|gh|ryP NVT6fFNkW0GQR1XS
EW-13 MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NID4fXdKSzVyPUKwMlU1PDNizszN MUPTRW5ITVJ?
Hs-578-T NWfEO|RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7WTWM2OD1{MD61OVg{KM7:TR?= MVLTRW5ITVJ?
SJSA-1 NXL6ZWZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTRUoxKSzVyPUKwMlU3QDhizszN M1fscXNCVkeHUh?=
RCC10RGB M{XSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInCcplKSzVyPUKwMlY4OTlizszN M{fReHNCVkeHUh?=
LAN-6 M4DPVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV60UmpUUUN3ME2yNU4xOzl4IN88US=> NH7YdWtUSU6JRWK=
NCI-H1048 NF;m[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\QTWM2OD1{MT6yNlU5KM7:TR?= MoDpV2FPT0WU
CW-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jtcWlEPTB;MkGuNlcxPSEQvF2= MlS4V2FPT0WU
HCC2157 M4\sU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjxeYNKSzVyPUKxMlM3KM7:TR?= MYLTRW5ITVJ?
EW-22 NXHDVW9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jYd2lEPTB;MkGuN|c3KM7:TR?= MYPTRW5ITVJ?
A253 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL2TWM2OD1{MT60OFgyKM7:TR?= M1vVPHNCVkeHUh?=
BE-13 NUj4TVQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL1d3ZxUUN3ME2yNU43OTF|IN88US=> NUHjN|dKW0GQR1XS
KINGS-1 NV\QfVd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJzLk[zNVYh|ryP Ml\5V2FPT0WU
ETK-1 NGTkSVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK4VoRKSzVyPUKxMlgyPTJizszN NWDlW5lNW0GQR1XS
NCI-H2452 MoXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPKdVZoUUN3ME2yNU45PjR5IN88US=> NWXvc2JjW0GQR1XS
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D-542MG NH;xNo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PoNmlEPTB;MkGuPVA3QSEQvF2= M1rqWHNCVkeHUh?=
NCI-H630 M1XSOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\zOZhKSzVyPUKyMlAzQTZizszN MXTTRW5ITVJ?
TGBC11TKB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTaTWM2OD1{Mj6wOFkh|ryP M3L0PHNCVkeHUh?=
BCPAP NU\IcWV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Pyc2lEPTB;MkKuOlEyKM7:TR?= MYHTRW5ITVJ?
HLE MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LBTmlEPTB;MkKuOlk4KM7:TR?= M36yZnNCVkeHUh?=
NCI-H727 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJ{LkezOUDPxE1? Mle4V2FPT0WU
RD NI\obZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DHeGlEPTB;MkKuO|UyQCEQvF2= NUHuO41qW0GQR1XS
NCI-H522 M{n3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ{Lki0N|Eh|ryP MmHBV2FPT0WU
CGTH-W-1 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X6T2lEPTB;MkOuNFY1OSEQvF2= NITRXXZUSU6JRWK=
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BB65-RCC M37uemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm2SGxKSzVyPUKzMlc5PjNizszN MWPTRW5ITVJ?
HSC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjndlNLUUN3ME2yN{45PTJ5IN88US=> M1:4UHNCVkeHUh?=
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DB NXjwclZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP5VmVkUUN3ME2yOE4yODJ6IN88US=> NVW2VoMxW0GQR1XS
HO-1-N-1 M{XXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfYUoVKSzVyPUK0MlMxQTNizszN NIixd3hUSU6JRWK=
MKN1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITxXFNKSzVyPUK0MlY5KM7:TR?= MV3TRW5ITVJ?
MN-60 NFHMWnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnziTWM2OD1{ND64OVE6KM7:TR?= MlH0V2FPT0WU
8505C MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHmbFFKSzVyPUK1MlE5PDVizszN MX\TRW5ITVJ?
COLO-320-HSR M1HtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPW[4d4UUN3ME2yOU4zOjB6IN88US=> MVnTRW5ITVJ?
BB30-HNC MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WxWWlEPTB;MkWuNlQ5OyEQvF2= NUX4eJFbW0GQR1XS
KM12 MoHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf5dHZKSzVyPUK1MlU5ODdizszN MmPYV2FPT0WU
NB13 NH\0WYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ3LkW4PVgh|ryP M365bnNCVkeHUh?=
HCC2998 Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJ4LkCyPFMh|ryP M{XSUnNCVkeHUh?=
U-118-MG MoPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLSTWM2OD1{Nj6wPFA5KM7:TR?= MluzV2FPT0WU
NB10 M4ThSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml35TWM2OD1{Nj6yN|Qh|ryP MWDTRW5ITVJ?
SK-LMS-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT0TWM2OD1{Nz6wO|A1KM7:TR?= NGHsb4xUSU6JRWK=
SW1573 M13JOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2H1S2lEPTB;MkeuNVEh|ryP M{fkd3NCVkeHUh?=
LB373-MEL-D M3To[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULubJI2UUN3ME2yO{4yOjl2IN88US=> NI\1XldUSU6JRWK=
DK-MG MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnCdYRKSzVyPUK3MlE5OTdizszN MkTBV2FPT0WU
RMG-I NFK4OHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJ5LkKwNlkh|ryP NUftSohYW0GQR1XS
SW1088 M3racGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnJdnh1UUN3ME2yO{42ODR{IN88US=> MlzIV2FPT0WU
SK-OV-3 M3HJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTkTWM2OD1{Nz63OVk{KM7:TR?= NXrLPXRRW0GQR1XS
KP-N-YN NXTRXGxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvsfFRnUUN3ME2yO{45ODR|IN88US=> NVeyR2NwW0GQR1XS
RPMI-7951 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYmzfHpTUUN3ME2yPE4zPDV4IN88US=> NV;BVG9WW0GQR1XS
CaR-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S1d2lEPTB;MkiuOVU5OiEQvF2= MkXQV2FPT0WU
MKN7 NX21cnRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f5VGlEPTB;MkiuOVk3PCEQvF2= NYCzdIE3W0GQR1XS
CHP-212 NHvRcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ6Lke0NFEh|ryP MWnTRW5ITVJ?
KYSE-450 M37YeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW4[ItwUUN3ME2yPE45ODlzIN88US=> NGXuN5hUSU6JRWK=
RXF393 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTJ7LkK5NFYh|ryP NYf0ZpF[W0GQR1XS
P30-OHK NXPWPXBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfDeY1ZUUN3ME2yPU4{ODR6IN88US=> NYnLcVZLW0GQR1XS
Ca9-22 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJ7LkSyPVkh|ryP NYHib3kzW0GQR1XS
RT-112 NVPafFRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\FU2lEPTB;MkmuOFYyOSEQvF2= NH3mVlhUSU6JRWK=
ES1 NXTxfWlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TBcWlEPTB;MkmuPFU1PCEQvF2= NUG5TnM6W0GQR1XS
HCE-4 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITpXIdKSzVyPUK5Mlg4QDZizszN MUjTRW5ITVJ?
AM-38 M2fM[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7aTWM2OD1|MD6wOlA3KM7:TR?= M1TzOXNCVkeHUh?=
AsPC-1 NFTtWFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofNTWM2OD1|MD64NFU{KM7:TR?= NF7GU3hUSU6JRWK=
TE-9 NF7yb3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\peWlEPTB;M{CuPFc{PyEQvF2= MWfTRW5ITVJ?
HuP-T4 M1q1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrZZpFKSzVyPUOwMlk3OzhizszN MXnTRW5ITVJ?
LB2518-MEL NHfPS|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vNemlEPTB;M{GuNFc1PCEQvF2= M1PDV3NCVkeHUh?=
NCI-H1703 M1\MRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\RTWM2OD1|MT6wPVA2KM7:TR?= NXiw[WxIW0GQR1XS
NCI-H2228 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TDR2lEPTB;M{GuOFY2OSEQvF2= MlPJV2FPT0WU
SCC-4 MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17GPGlEPTB;M{GuPVE5OSEQvF2= NGK0R|BUSU6JRWK=
KNS-81-FD M{KxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH0XFNKSzVyPUOyMlAyOjhizszN M{fMSXNCVkeHUh?=
NTERA-S-cl-D1 MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX0[oFKSzVyPUOyMlA4OzlizszN NILuUVlUSU6JRWK=
Daoy MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETDdIVKSzVyPUOyMlA5OzhizszN MmPUV2FPT0WU
ES4 M1m4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTN{LkO5NlIh|ryP MWrTRW5ITVJ?
MHH-ES-1 MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS2cYV3UUN3ME2zNk41QDd{IN88US=> NVHhSFAzW0GQR1XS
C-33-A MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVqzT2F5UUN3ME2zNk44PzJ6IN88US=> M17tUHNCVkeHUh?=
BHY MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX0fnNuUUN3ME2zNk46PDl3IN88US=> MVXTRW5ITVJ?
Detroit562 NVXmW3l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTN|Lk[2OVch|ryP NEjoU3ZUSU6JRWK=
EW-1 NVvrelhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrsXIxKSzVyPUOzMlk{OjJizszN NFW3VHpUSU6JRWK=
NCI-H1395 M13pVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4K5V2lEPTB;M{SuNFc6QSEQvF2= NWTrS3A5W0GQR1XS
KM-H2 M2THWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle3TWM2OD1|Nj60O|Q{KM7:TR?= M{fofXNCVkeHUh?=
NCI-H520 M{mwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTPTWM2OD1|Nj63OVQyKM7:TR?= NYHs[mN2W0GQR1XS
D-392MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkewTWM2OD1|Nz6zN|Q1KM7:TR?= NWToZoRvW0GQR1XS
NOMO-1 M3Hu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvxPFFNUUN3ME2zO{45ODh7IN88US=> MkXnV2FPT0WU
TE-6 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;QbGFKSzVyPUO4MlEzPCEQvF2= M2jsRnNCVkeHUh?=
HT-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPFfWRKSzVyPUO4MlQ1OzZizszN NHK1Z2NUSU6JRWK=
RPMI-8226 NHXJd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[2TWM2OD1|OD65OVE6KM7:TR?= MXnTRW5ITVJ?
U251 NVHvNYs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTN7LkCxNlQh|ryP Mn7MV2FPT0WU
GCT M13icmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknLTWM2OD1|OT6xPFUzKM7:TR?= MljrV2FPT0WU
A431 NXm5UGl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mny3TWM2OD1|OT6xPFk1KM7:TR?= NXvKNoRKW0GQR1XS
TE-12 NIPwW4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETJPY1KSzVyPUO5MlI1PDhizszN MWfTRW5ITVJ?
HMV-II NHj0dGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT1TWM2OD1|OT61NFQ4KM7:TR?= NIHQPJlUSU6JRWK=
IST-MES1 NX\F[2RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHHZ3NsUUN3ME20NE4yPTB{IN88US=> MXHTRW5ITVJ?
SW13 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjxdG1KSzVyPUSwMlUyQSEQvF2= MYnTRW5ITVJ?
SF295 M3L1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\lWWlEPTB;NECuPFA3PiEQvF2= NFvhOJNUSU6JRWK=
MDA-MB-157 Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[2VXJKSzVyPUSwMlk1PjJizszN MUnTRW5ITVJ?
TE-1 NWPqOnlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTRzLki3NVQh|ryP MUDTRW5ITVJ?
HuCCT1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTR{LkWyPFkh|ryP NIC5XppUSU6JRWK=
KYSE-510 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHQbFZKSzVyPUSzMlE4PTRizszN NHTWTJNUSU6JRWK=
NCI-H358 Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTR2LkCzNFQh|ryP Mmn5V2FPT0WU
SW900 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfDR2ZKSzVyPUS0MlA4PThizszN NFqw[G9USU6JRWK=
CAS-1 NGrjcm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[0UHJKSzVyPUS0MlA6QTFizszN M2TFUHNCVkeHUh?=
TE-8 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzjTWM2OD12ND61OlU5KM7:TR?= MWLTRW5ITVJ?
P12-ICHIKAWA MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLYSnNHUUN3ME20OE43OTF{IN88US=> MkPBV2FPT0WU
YKG-1 NX;xOFRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P2TmlEPTB;NESuO|gyKM7:TR?= MWHTRW5ITVJ?
SNU-C2B NEXsNm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVq1dmlCUUN3ME20OE44QTB|IN88US=> MkjIV2FPT0WU
LCLC-103H Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT0TWM2OD12ND64O|A{KM7:TR?= MUDTRW5ITVJ?
U-87-MG MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jJR2lEPTB;NEWuNVAzOiEQvF2= NFvBPFVUSU6JRWK=
HAL-01 M3m4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe4[nh[UUN3ME20OU4yOzd7IN88US=> NFS0[GdUSU6JRWK=
OVCAR-8 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXXOGE1UUN3ME20OU4{PTZ2IN88US=> NYjXcXRDW0GQR1XS
KYSE-150 NVXDNpR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mxWGlEPTB;NEeuNVA2OiEQvF2= M4rZXXNCVkeHUh?=
OE33 MlrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HCWGlEPTB;NEeuNVQzQSEQvF2= MUfTRW5ITVJ?
CAL-62 NEn5WXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn3[odKSzVyPUS3MlQxPjhizszN M1XEXnNCVkeHUh?=
TCCSUP NI\YW2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[3TWlEPTB;NEeuOlI3PCEQvF2= MVrTRW5ITVJ?
H4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofDTWM2OD12Nz62OlIyKM7:TR?= MoS3V2FPT0WU
CP66-MEL M{W4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfyNIo5UUN3ME20PE4xPzB2IN88US=> NVjnTWtLW0GQR1XS
SNB75 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTR6LkG4O|Qh|ryP NXHYe4dSW0GQR1XS
Mo-T NHi3W3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTR6LkK3PUDPxE1? NV3LTFBoW0GQR1XS
BT-549 NHLuS|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TlR2lEPTB;NEiuN|czQSEQvF2= MVrTRW5ITVJ?
IGR-1 NHHFVmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TTRWlEPTB;NEiuOlY1PSEQvF2= NYj6OmU1W0GQR1XS
NCI-H1299 NGP0VpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\MPWlEPTB;NEiuO|I1QCEQvF2= NIDIOHhUSU6JRWK=
ALL-PO MnXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPBUVZYUUN3ME20PU46OjZ6IN88US=> NIDqSGRUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]
臨床試験
特集

プロトコル (参考用のみ)

細胞アッセイ: [2]

細胞株 SW620, LoVo, V3-YAC and V3 cells
濃度 0.5 μM or 1 μM
反応時間 17 hours
実験の流れ The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.

動物実験: [2]

動物モデル Female rude mice bearing SW620 xenografts
製剤 Sterile 0.9% sodium chloride solution
投薬量 10 mg/kg
投与方法 Intraperitoneally administrated

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download NU7441 (KU-57788) SDF
分子量 413.49
化学式

C25H19NO3S

CAS No. 503468-95-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 3 mg/mL (7.25 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

文献中の引用 (15)

Frequently Asked Questions

  • Question 1
    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

    Answer: Slight color variation due to different processing is normal and usually doesn't interfere with the function.

技術サポート&よくある質問(FAQ)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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