NU7441 (KU-57788) 化学構造
分子量: 413.49

高品質保証

カスタマーフィードバック(4)

MSDS

製品説明

  • Compare DNA-PK Inhibitors
    DNA-PK製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 NU7441 (KU-57788)は一種の高度有効的で、選択性的なDNA-PK阻害剤で、無細胞試験でIC50値が14 nMになって、PI3Kも抑制して、このIC50値が5μMになります。
ターゲット DNA-PK
IC50 14 nM [1]
In vitro試験 NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H1770 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn25TWM2OD1yLkCyNVQ{KM7:TR?= NICzd5hUSU6JRWK=
A172 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnkNJpKSzVyPUCuNVU{OTZizszN MU\TRW5ITVJ?
NCI-H526 MmTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3XTWM2OD1yLkK4OFA4KM7:TR?= NFi2bXdUSU6JRWK=
HDLM-2 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3lcJZKSzVyPUCuN|I{PDVizszN MXTTRW5ITVJ?
HuO-3N1 MkXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwNE[2N|Yh|ryP NWfaPYhSW0GQR1XS
NCI-SNU-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHMTWM2OD1yLk[wPVk1KM7:TR?= NXPUblNzW0GQR1XS
SK-N-AS NGXQXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwNkKyNVYh|ryP M1n5VHNCVkeHUh?=
LoVo NYTzTGlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnuTWM2OD1yLki2O|Q6KM7:TR?= NW[1UIhHW0GQR1XS
LAMA-84 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nCPWlEPTB;MD65PFg{OyEQvF2= M{LkS3NCVkeHUh?=
CTB-1 MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK3RYFKSzVyPUGuNVE2PDZizszN NELobHRUSU6JRWK=
KP-N-YS MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr2b4trUUN3ME2xMlE1OjNzIN88US=> MnfhV2FPT0WU
HH M{X6eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTFwMUiwPVMh|ryP MYfTRW5ITVJ?
CHL-1 NWmzNGRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zOWGlEPTB;MT6yNVM3QCEQvF2= Ml7kV2FPT0WU
NB7 NIXSUW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorNTWM2OD1zLkK0O|Q2KM7:TR?= NES0Z41USU6JRWK=
HL-60 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLlNFBKSzVyPUGuN|gyQSEQvF2= MWrTRW5ITVJ?
639-V NIH5b41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK4TVFSUUN3ME2xMlQ1OTJ6IN88US=> NW\GWmxGW0GQR1XS
NCI-H1793 NEnx[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofVTWM2OD1zLkS1PFQh|ryP NV7IcG1SW0GQR1XS
NEC8 Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLDTWM2OD1zLkW1N|Uh|ryP NHP5emZUSU6JRWK=
PA-1 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjvc5RKSzVyPUGuOVgzQTRizszN MlPxV2FPT0WU
D-423MG MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlWwTWM2OD1zLk[5N|YyKM7:TR?= Ml73V2FPT0WU
NCI-H292 NW\GR5hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTFwN{SwNVMh|ryP NYrVWIZxW0GQR1XS
SK-MEL-1 NFntRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTFwN{m0O|kh|ryP Mm\hV2FPT0WU
LB2241-RCC NHvCN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnyzTWM2OD1{LkG0NVQ3KM7:TR?= MXLTRW5ITVJ?
SK-MEL-3 NEPLdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LC[2lEPTB;Mj6xOlQ6KM7:TR?= NUG4N4hwW0GQR1XS
MHH-PREB-1 MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Xl[2lEPTB;Mj6xOlYxQSEQvF2= NHzpbJZUSU6JRWK=
BFTC-905 NGHUW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\DTWM2OD1{LkG2Olg4KM7:TR?= MU\TRW5ITVJ?
Ramos-2G6-4C10 M3rZSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJwMUm5NFkh|ryP NXrsWGpMW0GQR1XS
G-361 NIXwR29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLNRpROUUN3ME2yMlIyPjhizszN NIDSfoVUSU6JRWK=
MOLT-4 NEfJVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXtUo9KSzVyPUKuNlE5QDhizszN NWLacpVvW0GQR1XS
DEL M4f2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJwM{W1OlQh|ryP MYnTRW5ITVJ?
MV-4-11 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPuRZNKSzVyPUKuN|c{QSEQvF2= MW\TRW5ITVJ?
SK-NEP-1 NFLIXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT0fIhqUUN3ME2yMlM5Pzh|IN88US=> M4nQVnNCVkeHUh?=
RS4-11 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHZ[VVKSzVyPUKuOVYxOjNizszN MmLrV2FPT0WU
HuH-7 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i2ZWlEPTB;Mj61OlcxOiEQvF2= MnSxV2FPT0WU
A101D M{DaXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHWdYZKSzVyPUKuOlE{OzhizszN NYX5WWFuW0GQR1XS
KG-1 M2jwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrWTWM2OD1{Lk[3PVI1KM7:TR?= MYLTRW5ITVJ?
KALS-1 NULIRm1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO1ZW5FUUN3ME2yMlY6PjN|IN88US=> NF7pfZdUSU6JRWK=
VMRC-RCZ NVLNRlZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2e4NmlEPTB;Mj63O|MzQCEQvF2= MoDlV2FPT0WU
SK-UT-1 MoDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPQTWM2OD1|LkG1N|Eh|ryP M4K4RnNCVkeHUh?=
SW962 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3Te5BKSzVyPUOuNlA{PTJizszN NGLBfnZUSU6JRWK=
DBTRG-05MG M2X4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq3OWxKSzVyPUOuNlgxQDVizszN MoewV2FPT0WU
PANC-08-13 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrsTWM2OD1|LkSxNlc5KM7:TR?= MlfZV2FPT0WU
QIMR-WIL M{[x[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvrTWM2OD1|LkSxN|QyKM7:TR?= NUSwUos3W0GQR1XS
SK-MEL-30 M1LPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;DW4VRUUN3ME2zMlQzPTl6IN88US=> NW[zcY52W0GQR1XS
697 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;NfWlEPTB;Mz60OFk6OyEQvF2= NVr2bVFlW0GQR1XS
NY NIjHVmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjxTWM2OD1|LkS1NFIzKM7:TR?= MXnTRW5ITVJ?
ES7 NFLSemFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv5TWM2OD1|LkS2O|I6KM7:TR?= MVvTRW5ITVJ?
JVM-3 Ml25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;mOWlEPTB;Mz60PFA4PyEQvF2= MlTKV2FPT0WU
U031 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT0bmNqUUN3ME2zMlU6OzZ6IN88US=> NHHxToxUSU6JRWK=
BHT-101 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnFend7UUN3ME2zMlU6QTh3IN88US=> M1LFfXNCVkeHUh?=
8305C M4i4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL5TWM2OD1|Lk[xO|M3KM7:TR?= Mn;HV2FPT0WU
MG-63 M{HETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTkTWM2OD1|Lk[yOlc3KM7:TR?= MkTaV2FPT0WU
NOS-1 NFO3dm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfDTWM2OD1|Lk[1N|EzKM7:TR?= MWjTRW5ITVJ?
YH-13 MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX1TWM2OD1|Lki3NVg6KM7:TR?= MVzTRW5ITVJ?
LXF-289 NF\yfmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\sPGlEPTB;Mz65NVA1OSEQvF2= MX;TRW5ITVJ?
GOTO NFTicFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnriTWM2OD1|LkmxOFkh|ryP MYHTRW5ITVJ?
EKVX M2TGOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWO5fY1DUUN3ME20MlIzPTJ2IN88US=> MlzHV2FPT0WU
CAL-51 Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X4NmlEPTB;ND6yOFg2PCEQvF2= MYrTRW5ITVJ?
AN3-CA M4G3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\SXWtGUUN3ME20MlI2QDF|IN88US=> NH\Q[JFUSU6JRWK=
IA-LM NVTyfY9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLkUoRKSzVyPUSuNlc6OzVizszN Mk\IV2FPT0WU
KU-19-19 M2PxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTRwM{K5NlEh|ryP NFrFO3VUSU6JRWK=
A704 M4\pTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17MUWlEPTB;ND60NFg5QCEQvF2= M3v0d3NCVkeHUh?=
RH-18 NHf3bGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF34fW5KSzVyPUSuOFQ6PTNizszN MkC4V2FPT0WU
IST-MEL1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\mOWdKSzVyPUSuOVgzPjNizszN NUHQN|F7W0GQR1XS
LU-134-A MoP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7UNYVKSzVyPUSuOVk3QDVizszN NHX1XGhUSU6JRWK=
SF126 NVjXNZdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;zc2dvUUN3ME20MlYxPzF3IN88US=> MVnTRW5ITVJ?
EFO-27 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTRwNk[1NlUh|ryP M2H6Z3NCVkeHUh?=
SN12C NV;NcpVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTsVG06UUN3ME20MlcyQDl6IN88US=> NW\mfJdXW0GQR1XS
L-363 NEH5[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jyPWlEPTB;ND63O|EyPiEQvF2= MmjWV2FPT0WU
MEL-HO MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi4ZoVKUUN3ME20Mlc4QTh7IN88US=> MkLuV2FPT0WU
TYK-nu Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTRwOECxNlgh|ryP NVnY[VhtW0GQR1XS
MDA-MB-415 M3vHdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LkSGlEPTB;NT6wNFMyPCEQvF2= MlHqV2FPT0WU
HCC70 Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzETWM2OD13LkCzPVM6KM7:TR?= M3[3WXNCVkeHUh?=
IGROV-1 M4DHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELPTnNKSzVyPUWuNlUzQTJizszN M{XKdXNCVkeHUh?=
NCI-H1355 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon3TWM2OD13LkK5OkDPxE1? NFzPOJJUSU6JRWK=
23132-87 MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7qUndZUUN3ME21MlMzODJ2IN88US=> NEjxNXVUSU6JRWK=
NB69 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjqTWM2OD13LkOyOFIh|ryP M{S3fHNCVkeHUh?=
HSC-2 M3[2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHXWoE6UUN3ME21MlQyPzd|IN88US=> MV3TRW5ITVJ?
KYSE-410 Mly5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vPdmlEPTB;NT60O|Y{PiEQvF2= MXvTRW5ITVJ?
GCIY MljNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2S1d2lEPTB;NT61NVM4QCEQvF2= M1TvPHNCVkeHUh?=
A427 M1fVXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PXPWlEPTB;NT61N|Y3OSEQvF2= NIDwRnZUSU6JRWK=
ChaGo-K-1 NVWxU|VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fOR2lEPTB;NT61OlU6QSEQvF2= MW\TRW5ITVJ?
PFSK-1 NUntWnFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTp[oZKSzVyPUWuOlIyQTRizszN NFnRSpNUSU6JRWK=
MLMA NWnlXFhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTVwOEO2NFYh|ryP NF3k[GhUSU6JRWK=
RVH-421 MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPvfXZyUUN3ME22MlA4OzN6IN88US=> NWTPVYs2W0GQR1XS
LB1047-RCC NWK0coVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTJb2dCUUN3ME22MlE4PTJ{IN88US=> M3;rUHNCVkeHUh?=
MHH-NB-11 NGe1SI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjwT2xKSzVyPU[uN|I4OjFizszN MWjTRW5ITVJ?
J-RT3-T3-5 NYWyNmV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFK1OFFKSzVyPU[uOlMzQTFizszN M3fOdHNCVkeHUh?=
UM-UC-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTZwNkSzN|Qh|ryP M2LhXHNCVkeHUh?=
IST-SL1 NWPSNpU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LmNGlEPTB;Nj62PVM3QSEQvF2= NUDGOIVCW0GQR1XS
NB14 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTYTWM2OD14Lke5O|YyKM7:TR?= M124V3NCVkeHUh?=
NBsusSR NHjaSHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3TO|NtUUN3ME22MlgzPTB{IN88US=> MYrTRW5ITVJ?
D-263MG MlzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTZwOUGwOlgh|ryP MULTRW5ITVJ?
NCI-H2347 NWDEXlY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPSTWM2OD14LkmzNlE{KM7:TR?= MljKV2FPT0WU
ES8 M4HScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkCzTWM2OD14Lkm3OVg5KM7:TR?= NUPZOYc5W0GQR1XS
786-0 M2\JUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFX2Sm9KSzVyPUeuNFk4QDZizszN MU\TRW5ITVJ?
EPLC-272H MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\RR5ZKSzVyPUeuNVYzPDZizszN NVvERWE5W0GQR1XS
CAPAN-1 NVj3bmVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvRe2tKSzVyPUeuNlQ{PTlizszN MkC3V2FPT0WU
NCI-H82 M3Gy[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTdwMk[2OVkh|ryP M4L3W3NCVkeHUh?=
G-402 M4\zOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTdwM{CwOVEh|ryP MlO0V2FPT0WU
SW982 NHjMd3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXZTWM2OD15LkOwNlA{KM7:TR?= NWj5NIdCW0GQR1XS
OVCAR-4 MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\KTWM2OD15LkOxN|I5KM7:TR?= NHfiTZJUSU6JRWK=
KARPAS-299 M1HVXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HtcmlEPTB;Nz6zNlYzOiEQvF2= NWLOO3FGW0GQR1XS
MIA-PaCa-2 NWHINXNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfyTWM2OD15LkO2PFI{KM7:TR?= NH\kdWZUSU6JRWK=
AU565 NVmyNmFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDPbHlKSzVyPUeuOVk5OzNizszN NEDz[VFUSU6JRWK=
GAMG NGTBR49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Pz[WlEPTB;Nz62OFE{OSEQvF2= MXjTRW5ITVJ?
HuO9 M12xfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3Pd2E4UUN3ME23MlcyPzR|IN88US=> M{PSSnNCVkeHUh?=
ACN MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTMTWM2OD15Lke0N|Mh|ryP NEjQeHBUSU6JRWK=
RO82-W-1 NID5eHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fBSmlEPTB;Nz63OFU{OyEQvF2= Ml3EV2FPT0WU
NKM-1 M4nLfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[zTYhKSzVyPUeuO|Q6PTVizszN NV[ybnJtW0GQR1XS
CAL-12T M2nqbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTdwOUSzOVIh|ryP M3vkZnNCVkeHUh?=
FADU NWW0N2Q4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\xN5RKSzVyPUiuNFM3PTRizszN NHfvTm1USU6JRWK=
NCI-H28 NGfLW3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4O2O2lEPTB;OD6xOlk3OiEQvF2= NEXaUo9USU6JRWK=
LCLC-97TM1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUWwVm1ZUUN3ME24MlIyOTJ{IN88US=> MVrTRW5ITVJ?
CHP-134 NUi5c2oxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrvTJZKSzVyPUiuNlQyQDVizszN NYHIT4loW0GQR1XS
HT-1080 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvVcpBKSzVyPUiuNlUxQTNizszN NEfBfVVUSU6JRWK=
PC-3 MoPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r5RmlEPTB;OD6yO|M6OiEQvF2= NI\GbXhUSU6JRWK=
SNU-449 NVizZYlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTxV|U1UUN3ME24MlI4QTNizszN Mlr1V2FPT0WU
VA-ES-BJ MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRThwM{S2PFYh|ryP M4LI[XNCVkeHUh?=
HT M4HINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRThwM{[0PUDPxE1? NXf3OHZOW0GQR1XS
HOS NWL1fnROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fnWmlEPTB;OD6zO|U5QSEQvF2= M3m3PHNCVkeHUh?=
KNS-62 NVnnVXVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;MOYZKSzVyPUiuN|c4PjJizszN M1XYOnNCVkeHUh?=
OAW-42 M2fwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7sWFZTUUN3ME24Mlk2QTZ2IN88US=> M4DPO3NCVkeHUh?=
A549 M3PxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G0[mlEPTB;OT6wPVYyOiEQvF2= NFWyd2FUSU6JRWK=
CAKI-1 NFvwZnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTlwMU[2NUDPxE1? M1zkRXNCVkeHUh?=
HCC1937 M1T6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXuzeodZUUN3ME25MlY6QDZ3IN88US=> NWn1doM5W0GQR1XS
GI-ME-N MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTBTnpHUUN3ME25MlcxOTN5IN88US=> MnfTV2FPT0WU
DU-4475 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEP6dVNKSzVyPUmuPVY6OzlizszN NFHsd25USU6JRWK=
EM-2 M4L4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MontTWM2OD1zMD6yOFI3KM7:TR?= Mn\BV2FPT0WU
NCI-H1755 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHnPWFKSzVyPUGwMlI1OjhizszN M3LzT3NCVkeHUh?=
NCI-H1437 M2W3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTnW29KSzVyPUGwMlU4OjVizszN NE\GZmRUSU6JRWK=
VM-CUB-1 NF3nPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTFyLk[xOlQh|ryP NF3wWnJUSU6JRWK=
A2058 M2fsRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HNWGlEPTB;MUCuOlQxPCEQvF2= NXLSWlV3W0GQR1XS
BPH-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\tSmlEPTB;MUCuO|E1PSEQvF2= M4\rXnNCVkeHUh?=
NB5 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfYRnBxUUN3ME2xNE44PTV7IN88US=> NF\GSWZUSU6JRWK=
G-401 MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEK1S|ZKSzVyPUGwMlc3OjZizszN MnTNV2FPT0WU
CAL-72 M{PVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPXNoRKSzVyPUGwMlgxQTRizszN MYLTRW5ITVJ?
SK-MEL-28 NV\JRnh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPETWM2OD1zMD64NlAzKM7:TR?= MV\TRW5ITVJ?
C32 MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjHZnZHUUN3ME2xNE45OzR5IN88US=> NE\jU3pUSU6JRWK=
NCI-H1155 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T3O2lEPTB;MUCuPFM4PiEQvF2= MUjTRW5ITVJ?
BB49-HNC NI[1OIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYT2UndQUUN3ME2xNE45PTh4IN88US=> M1vhZXNCVkeHUh?=
GMS-10 NW\GV45YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjNOmxvUUN3ME2xNE45QTdzIN88US=> M3Kxd3NCVkeHUh?=
K5 M4HBSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fZcmlEPTB;MUCuPVA4OSEQvF2= MlLjV2FPT0WU
OS-RC-2 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XhSWlEPTB;MUGuNFU2QSEQvF2= NHrvVItUSU6JRWK=
HTC-C3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[4R3RKSzVyPUGxMlA4OTRizszN NVj2SZlVW0GQR1XS
LB996-RCC NXzJfGdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7tV5JKSzVyPUGxMlA4OjNizszN NUPXeIVHW0GQR1XS
NCI-H1563 NWG5XJFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPLcWoyUUN3ME2xNU4yODFzIN88US=> MWfTRW5ITVJ?
CAL-54 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULQZW14UUN3ME2xNU41QDFzIN88US=> M4\ZSHNCVkeHUh?=
WM-115 M3S1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXDemZJUUN3ME2xNU43QDJ2IN88US=> MYDTRW5ITVJ?
COLO-684 M2\PRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXXZ4lKSzVyPUGxMlczPjdizszN M3PLV3NCVkeHUh?=
HOP-62 NUL4bIpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYGzflM1UUN3ME2xNU44PTB6IN88US=> NW\LZ5gzW0GQR1XS
NCI-H650 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTFzLki5OlEh|ryP MlHmV2FPT0WU
TE-11 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLMTWM2OD1zMT65N|E2KM7:TR?= MXLTRW5ITVJ?
COLO-679 M3;kXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfOTWM2OD1zMT65OFYh|ryP NI\Qe|NUSU6JRWK=
FTC-133 M2m5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn5TWM2OD1zMj6wNFc3KM7:TR?= MULTRW5ITVJ?
D-283MED MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\hTWM2OD1zMj6wOVY6KM7:TR?= NV65WFJrW0GQR1XS
SK-PN-DW MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF{LkG5NFIh|ryP MXHTRW5ITVJ?
BALL-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LO[mlEPTB;MUKuNlY3OiEQvF2= NFjGendUSU6JRWK=
GT3TKB MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF{LkOwO|Qh|ryP M4XFRnNCVkeHUh?=
HOP-92 M2jheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF{LkWyN|Mh|ryP Ml[zV2FPT0WU
M14 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH35VItKSzVyPUGzMlA{OzVizszN NHi4UGlUSU6JRWK=
SKG-IIIa MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF|LkC1OVQh|ryP NXzPWWllW0GQR1XS
Becker NH24S3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzmUpdKSzVyPUGzMlA2QCEQvF2= MVnTRW5ITVJ?
ES5 M1mwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T6SGlEPTB;MUOuNVM2PiEQvF2= NVXhZnRrW0GQR1XS
NCI-H2030 M1HaN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny1TWM2OD1zMz6yNFYzKM7:TR?= MYTTRW5ITVJ?
SNU-423 M3PldGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPLTWM2OD1zMz6zPFEh|ryP NXuzZVdEW0GQR1XS
CP50-MEL-B M1vQSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTF|Lk[yN|Ih|ryP NVzwN2FzW0GQR1XS
NCI-H1092 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7LUVcyUUN3ME2xN{44PDd3IN88US=> MWnTRW5ITVJ?
8-MG-BA MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTF|Lke1NVMh|ryP NI\wemNUSU6JRWK=
CAL-27 MoXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\1TWM2OD1zND6wO|I4KM7:TR?= NEDmOWdUSU6JRWK=
AGS NHvnXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHUNXJKSzVyPUG0MlE{OTlizszN Mof4V2FPT0WU
MZ2-MEL NWPkV3N1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInzOGFKSzVyPUG0MlE1QDhizszN NXrKU2hYW0GQR1XS
BFTC-909 NYTKfVZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTZTWM2OD1zND61NFU2KM7:TR?= NYDaWoJ4W0GQR1XS
D-566MG NFvvPWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvoZnJKSzVyPUG0Mlc4ODZizszN MkHXV2FPT0WU
MZ7-mel NI\FcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHZTWM2OD1zNT6xNFY4KM7:TR?= MVLTRW5ITVJ?
TE-5 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHy5VVRKSzVyPUG1MlI{OzNizszN MW\TRW5ITVJ?
647-V NGrIeIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i4NmlEPTB;MUWuNlcxPSEQvF2= Mn3TV2FPT0WU
DMS-114 M4fHTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLaXHZKSzVyPUG1MlMzQTFizszN MmLVV2FPT0WU
ME-180 M1ftc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zlOGlEPTB;MUWuOFc5OyEQvF2= MWrTRW5ITVJ?
MS-1 NXXSNmdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4j5S2lEPTB;MUWuOVYzOyEQvF2= NEH1WZZUSU6JRWK=
NUGC-3 NHzmcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj0N4VKSzVyPUG1MlYzPDVizszN NXHsboxiW0GQR1XS
GB-1 NWHNb3FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrORZVUUUN3ME2xOU43PDN5IN88US=> NYfoXHdqW0GQR1XS
LOXIMVI NFfhcFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrpPGZKSzVyPUG1Mlg6OTlizszN NFL3RYJUSU6JRWK=
NCI-H1304 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXVfnVKSzVyPUG1Mlg6OjhizszN NHTBUHJUSU6JRWK=
KURAMOCHI MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfhWGJKSzVyPUG1Mlk4OSEQvF2= NFHQW3pUSU6JRWK=
SW1783 NXTNb|lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\wTWM2OD1zNj6wPVk{KM7:TR?= M3X3XnNCVkeHUh?=
EGI-1 NYDxOY5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTF4LkWzOlUh|ryP MmfCV2FPT0WU
KGN MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rFTWlEPTB;MU[uOVU5PiEQvF2= MkSxV2FPT0WU
PANC-03-27 NVnjTXRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1eySGlEPTB;MU[uO|Y3OiEQvF2= MU\TRW5ITVJ?
RH-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWm0eW9pUUN3ME2xOk45OjVizszN NGfJTpJUSU6JRWK=
HT-1376 MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXS5dXl[UUN3ME2xOk45PDR4IN88US=> Mk\uV2FPT0WU
ZR-75-30 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z5PWlEPTB;MU[uPVM3OSEQvF2= NYr4N|B4W0GQR1XS
TI-73 MmDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHSfJY2UUN3ME2xOk46PDB6IN88US=> MVPTRW5ITVJ?
TK10 M2jVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi4[ZNSUUN3ME2xO{4xODd7IN88US=> MYXTRW5ITVJ?
SW684 M2D4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGO0XGxKSzVyPUG3MlAyPTRizszN M1jBWnNCVkeHUh?=
RPMI-8866 NXXXS4w2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF5LkC2PVkh|ryP MUDTRW5ITVJ?
LNCaP-Clone-FGC NVXsZ245T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu4U3UxUUN3ME2xO{42OjBzIN88US=> NFrGNGdUSU6JRWK=
NCI-H2291 Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnlOnV[UUN3ME2xPE41OzR3IN88US=> M2XxWHNCVkeHUh?=
T47D MlfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnXTWM2OD1zOD60PFgh|ryP NV\qfXNFW0GQR1XS
A204 M4jUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTF6LkW0OVIh|ryP MlTXV2FPT0WU
HT-144 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHsTWM2OD1zOD63OFI4KM7:TR?= NFO2[HhUSU6JRWK=
MDA-MB-361 M1HHfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWyV4pkUUN3ME2xPU4xPzF2IN88US=> M1;se3NCVkeHUh?=
HCC1806 M2PEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7sTWM2OD1zOT6xOVkyKM7:TR?= MkXFV2FPT0WU
NCI-H596 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PiNGlEPTB;MUmuOlM6OSEQvF2= M1;Se3NCVkeHUh?=
K-562 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL0VpZWUUN3ME2xPU45QTJ4IN88US=> M{LwWHNCVkeHUh?=
D-336MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTF7LkmzNlIh|ryP M2PodHNCVkeHUh?=
SK-MEL-2 M{nxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJyLkG1OVkh|ryP M133[HNCVkeHUh?=
HEC-1 NH7Md3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;yclhKSzVyPUKwMlQ6PzhizszN M3;EVXNCVkeHUh?=
EW-13 NW\j[ZhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorsTWM2OD1{MD61OFQ{KM7:TR?= NGLhPZdUSU6JRWK=
Hs-578-T MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULKeFk1UUN3ME2yNE42PTh|IN88US=> NWnzSGV{W0GQR1XS
SJSA-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJyLkW2PFgh|ryP NE\WPIZUSU6JRWK=
RCC10RGB NEj1WIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJyLk[3NVkh|ryP NHLtN4ZUSU6JRWK=
LAN-6 NH\icZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJzLkCzPVYh|ryP MVvTRW5ITVJ?
NCI-H1048 NX7McVJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJzLkKyOVgh|ryP NVnVXWR4W0GQR1XS
CW-2 M{nWXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXDPJdEUUN3ME2yNU4zPzB3IN88US=> NUjLe3BJW0GQR1XS
HCC2157 NECzNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC0TWM2OD1{MT6zOkDPxE1? M3;DXXNCVkeHUh?=
EW-22 NVPqO2NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJzLkO3OkDPxE1? NXHM[G5wW0GQR1XS
A253 MnHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW0VZJKSzVyPUKxMlQ1QDFizszN MmLiV2FPT0WU
BE-13 MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJzLk[xNVMh|ryP MWXTRW5ITVJ?
KINGS-1 Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DZfmlEPTB;MkGuOlMyPiEQvF2= MlfGV2FPT0WU
ETK-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDDNWZKSzVyPUKxMlgyPTJizszN M4PzPXNCVkeHUh?=
NCI-H2452 NH\2bFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Hlb2lEPTB;MkGuPFY1PyEQvF2= NUDjOnh{W0GQR1XS
HPAF-II MoLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TFT2lEPTB;MkGuPFkzOyEQvF2= MVHTRW5ITVJ?
D-542MG NGP1VoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDUTWM2OD1{MT65NFY6KM7:TR?= NFraelFUSU6JRWK=
NCI-H630 NVXWepdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHQUphKSzVyPUKyMlAzQTZizszN NG\IV3BUSU6JRWK=
TGBC11TKB MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TVbWlEPTB;MkKuNFQ6KM7:TR?= MXTTRW5ITVJ?
BCPAP NFXod3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nHNGlEPTB;MkKuOlEyKM7:TR?= NWnEcIFzW0GQR1XS
HLE NXLOSZRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHoTWM2OD1{Mj62PVch|ryP MmrtV2FPT0WU
NCI-H727 NX[4ZnlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHGwfopKSzVyPUKyMlc{PSEQvF2= NVHqUW9oW0GQR1XS
RD NEfTTWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFO5e3pKSzVyPUKyMlc2OThizszN NGLqT2dUSU6JRWK=
NCI-H522 NEjoUmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j2XGlEPTB;MkKuPFQ{OSEQvF2= M4T5bnNCVkeHUh?=
CGTH-W-1 NXvaeWxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDITWM2OD1{Mz6wOlQyKM7:TR?= MYrTRW5ITVJ?
SK-LU-1 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LmcWlEPTB;MkOuOFY5OyEQvF2= NGqzNXJUSU6JRWK=
BB65-RCC MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJ|Lke4OlMh|ryP NVzFRnNQW0GQR1XS
HSC-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv5TWM2OD1{Mz64OVI4KM7:TR?= NFHW[VNUSU6JRWK=
SK-MES-1 M2raT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XveWlEPTB;MkSuNFE3OSEQvF2= MnO1V2FPT0WU
DB M{X3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq4OVNKSzVyPUK0MlExOjhizszN M1HIOnNCVkeHUh?=
HO-1-N-1 NWTLVIhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJ2LkOwPVMh|ryP NV7tVphiW0GQR1XS
MKN1 M3rBS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rvVmlEPTB;MkSuOlgh|ryP M4fiRnNCVkeHUh?=
MN-60 NUi5[WZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTJ2Lki1NVkh|ryP Mm\kV2FPT0WU
8505C MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MniyTWM2OD1{NT6xPFQ2KM7:TR?= M36ye3NCVkeHUh?=
COLO-320-HSR MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\w[GlEPTB;MkWuNlIxQCEQvF2= NUDBd|FHW0GQR1XS
BB30-HNC M13nXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJ3LkK0PFMh|ryP MXzTRW5ITVJ?
KM12 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zFeWlEPTB;MkWuOVgxPyEQvF2= MlnOV2FPT0WU
NB13 M{f1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJ3LkW4PVgh|ryP M1vYUXNCVkeHUh?=
HCC2998 Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJ4LkCyPFMh|ryP MX3TRW5ITVJ?
U-118-MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rhWGlEPTB;Mk[uNFgxQCEQvF2= MnTMV2FPT0WU
NB10 NUTWTYFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoflTWM2OD1{Nj6yN|Qh|ryP MlvPV2FPT0WU
SK-LMS-1 M4i3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe2Z4RNUUN3ME2yO{4xPzB2IN88US=> M1\1XXNCVkeHUh?=
SW1573 NGC2eZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jyTGlEPTB;MkeuNVEh|ryP NWrBfXpMW0GQR1XS
LB373-MEL-D NW\nb3NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzaemR7UUN3ME2yO{4yOjl2IN88US=> MkXwV2FPT0WU
DK-MG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTVOVFKSzVyPUK3MlE5OTdizszN NXvUTpl{W0GQR1XS
RMG-I NV;4TIx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj5[WpvUUN3ME2yO{4zODJ7IN88US=> MWDTRW5ITVJ?
SW1088 NHH4RnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3vTWM2OD1{Nz61NFQzKM7:TR?= MVjTRW5ITVJ?
SK-OV-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3ueJFxUUN3ME2yO{44PTl|IN88US=> NWrWdW91W0GQR1XS
KP-N-YN NFjQfmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHwTWM2OD1{Nz64NFQ{KM7:TR?= MXjTRW5ITVJ?
RPMI-7951 NWrGcIdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPqcnVKSzVyPUK4MlI1PTZizszN MVvTRW5ITVJ?
CaR-1 NWTTcXMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3W3eWlEPTB;MkiuOVU5OiEQvF2= NU\tTmFmW0GQR1XS
MKN7 MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrMRYVKSzVyPUK4MlU6PjRizszN MX3TRW5ITVJ?
CHP-212 MljoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX0TWM2OD1{OD63OFAyKM7:TR?= MX\TRW5ITVJ?
KYSE-450 MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX2VlRKSzVyPUK4MlgxQTFizszN NX7MUYN4W0GQR1XS
RXF393 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLsNoJKSzVyPUK5MlI6ODZizszN NGnuRXBUSU6JRWK=
P30-OHK NFq0e5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmzVYpKSzVyPUK5MlMxPDhizszN NUTTUHh6W0GQR1XS
Ca9-22 NFOxWIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XLT2lEPTB;MkmuOFI6QSEQvF2= M3fIdXNCVkeHUh?=
RT-112 NFPseGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjHbnNbUUN3ME2yPU41PjFzIN88US=> MWfTRW5ITVJ?
ES1 MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHDeZBKSzVyPUK5Mlg2PDRizszN MV3TRW5ITVJ?
HCE-4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfTS4xKSzVyPUK5Mlg4QDZizszN M2jlVHNCVkeHUh?=
AM-38 MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnzTWM2OD1|MD6wOlA3KM7:TR?= NU\LV4hWW0GQR1XS
AsPC-1 NGDkT|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjrTWM2OD1|MD64NFU{KM7:TR?= NVzkd2ZNW0GQR1XS
TE-9 M{nVdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXRcm51UUN3ME2zNE45PzN5IN88US=> M4TyenNCVkeHUh?=
HuP-T4 NEnlb29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi3b|VGUUN3ME2zNE46PjN6IN88US=> MWPTRW5ITVJ?
LB2518-MEL MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13BemlEPTB;M{GuNFc1PCEQvF2= NWnRdJNMW0GQR1XS
NCI-H1703 NYLZblBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX6TWM2OD1|MT6wPVA2KM7:TR?= NEPTVIpUSU6JRWK=
NCI-H2228 NXLZR|J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PzXmlEPTB;M{GuOFY2OSEQvF2= NYHoW4EyW0GQR1XS
SCC-4 NXPRN5VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnnN25HUUN3ME2zNU46OThzIN88US=> MWfTRW5ITVJ?
KNS-81-FD M3\sc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN{LkCxNlgh|ryP NEXDXGFUSU6JRWK=
NTERA-S-cl-D1 NIHKVnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:2cXNKSzVyPUOyMlA4OzlizszN MVTTRW5ITVJ?
Daoy NVXhUZB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTN{LkC4N|gh|ryP MV7TRW5ITVJ?
ES4 Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPhbHBKSzVyPUOyMlM6OjJizszN NHrPNHVUSU6JRWK=
MHH-ES-1 MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HJcWlEPTB;M{KuOFg4OiEQvF2= NYnVfIx[W0GQR1XS
C-33-A Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\UTWM2OD1|Mj63O|I5KM7:TR?= NIPwfWdUSU6JRWK=
BHY Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP0XVBKSzVyPUOyMlk1QTVizszN MXLTRW5ITVJ?
Detroit562 NELTdIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTN|Lk[2OVch|ryP MUTTRW5ITVJ?
EW-1 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTN|LkmzNlIh|ryP Mn;YV2FPT0WU
NCI-H1395 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXv6cIkyUUN3ME2zOE4xPzl7IN88US=> NEPXV3JUSU6JRWK=
KM-H2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rJbWlEPTB;M{[uOFc1OyEQvF2= NUe3Z4V7W0GQR1XS
NCI-H520 NUm5XmY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTN4Lke1OFEh|ryP M4\VfXNCVkeHUh?=
D-392MG NUCzcphJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTN5LkOzOFQh|ryP NHPKO5VUSU6JRWK=
NOMO-1 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\Pc4pKSzVyPUO3MlgxQDlizszN M2TINHNCVkeHUh?=
TE-6 M1TkZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorsTWM2OD1|OD6xNlQh|ryP MXzTRW5ITVJ?
HT-3 NHu3SIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly3TWM2OD1|OD60OFM3KM7:TR?= NE\tZmFUSU6JRWK=
RPMI-8226 NGfjUlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\kdYJKSzVyPUO4Mlk2OTlizszN NIi5eGpUSU6JRWK=
U251 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\VUWxKSzVyPUO5MlAyOjRizszN MlfRV2FPT0WU
GCT MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3wTWM2OD1|OT6xPFUzKM7:TR?= M4TnfHNCVkeHUh?=
A431 NEPCWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC1TWM2OD1|OT6xPFk1KM7:TR?= M2e2d3NCVkeHUh?=
TE-12 MkDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nOV2lEPTB;M{muNlQ1QCEQvF2= MX\TRW5ITVJ?
HMV-II NEnqdXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mke1TWM2OD1|OT61NFQ4KM7:TR?= NHvXd5VUSU6JRWK=
IST-MES1 MmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDZTWM2OD12MD6xOVAzKM7:TR?= NVPX[m1iW0GQR1XS
SW13 Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjJZZpJUUN3ME20NE42OTlizszN MoXTV2FPT0WU
SF295 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi5SnREUUN3ME20NE45ODZ4IN88US=> M3qwUXNCVkeHUh?=
MDA-MB-157 NVPUV3dsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfETWM2OD12MD65OFYzKM7:TR?= NI[wZldUSU6JRWK=
TE-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULERm9XUUN3ME20NU45PzF2IN88US=> MYXTRW5ITVJ?
HuCCT1 NHL4R2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jJe2lEPTB;NEKuOVI5QSEQvF2= NHLtbWhUSU6JRWK=
KYSE-510 MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq5W4NvUUN3ME20N{4yPzV2IN88US=> NYTT[ldzW0GQR1XS
NCI-H358 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17sNWlEPTB;NESuNFMxPCEQvF2= MXHTRW5ITVJ?
SW900 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LtWGlEPTB;NESuNFc2QCEQvF2= M3XpNHNCVkeHUh?=
CAS-1 MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHCTWM2OD12ND6wPVkyKM7:TR?= MYDTRW5ITVJ?
TE-8 M3nPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfIeIFQUUN3ME20OE42PjV6IN88US=> NVzPOowzW0GQR1XS
P12-ICHIKAWA MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XvNGlEPTB;NESuOlEyOiEQvF2= NEfsb|ZUSU6JRWK=
YKG-1 NVzR[5VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnexTWM2OD12ND63PFEh|ryP NV\WelBZW0GQR1XS
SNU-C2B NVLqeHI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTR2Lke5NFMh|ryP M{niN3NCVkeHUh?=
LCLC-103H NVjI[IxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTCTWM2OD12ND64O|A{KM7:TR?= NIra[JlUSU6JRWK=
U-87-MG M1PRTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HLU2lEPTB;NEWuNVAzOiEQvF2= M2PhVnNCVkeHUh?=
HAL-01 MkKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jJOmlEPTB;NEWuNVM4QSEQvF2= Mn;LV2FPT0WU
OVCAR-8 NHiwe2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nzPGlEPTB;NEWuN|U3PCEQvF2= NGGzbmVUSU6JRWK=
KYSE-150 NUj2b4Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rPO2lEPTB;NEeuNVA2OiEQvF2= NUfCc4t2W0GQR1XS
OE33 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\XTWM2OD12Nz6xOFI6KM7:TR?= MoPGV2FPT0WU
CAL-62 M3rtPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTR5LkSwOlgh|ryP NFPWWFZUSU6JRWK=
TCCSUP NYjtcmx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi3XWxJUUN3ME20O{43OjZ2IN88US=> MUnTRW5ITVJ?
H4 NXXWfFhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvSbJJKSzVyPUS3MlY3OjFizszN M3;OVHNCVkeHUh?=
CP66-MEL M2DF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTR6LkC3NFQh|ryP MXfTRW5ITVJ?
SNB75 NYn3RodnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnOxTWM2OD12OD6xPFc1KM7:TR?= MmXmV2FPT0WU
Mo-T MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPGTWM2OD12OD6yO|kh|ryP M4\zeXNCVkeHUh?=
BT-549 NHHKSVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXh[lFZUUN3ME20PE4{PzJ7IN88US=> MWjTRW5ITVJ?
IGR-1 NUDMUolrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTWdGY5UUN3ME20PE43PjR3IN88US=> MXHTRW5ITVJ?
NCI-H1299 MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfuV3JIUUN3ME20PE44OjR6IN88US=> NG[0c2ZUSU6JRWK=
ALL-PO NV3XRXZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVL4fIU6UUN3ME20PU46OjZ6IN88US=> NWjxOHoyW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]
臨床試験
特集

プロトコル (参考用のみ)

細胞アッセイ: [2]

細胞株 SW620, LoVo, V3-YAC and V3 cells
濃度 0.5 μM or 1 μM
反応時間 17 hours
実験の流れ The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.

動物実験: [2]

動物モデル Female rude mice bearing SW620 xenografts
製剤 Sterile 0.9% sodium chloride solution
投薬量 10 mg/kg
投与方法 Intraperitoneally administrated

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download NU7441 (KU-57788) SDF
分子量 413.49
化学式

C25H19NO3S

CAS No. 503468-95-9
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 4 mg/mL warming (9.67 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

文献中の引用 (15)

Frequently Asked Questions

  • Question 1
    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

    Answer: Slight color variation due to different processing is normal and usually doesn't interfere with the function.

技術サポート&よくある質問(FAQ)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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