NU7441 (KU-57788) 化学構造
分子量: 413.49

高品質保証

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Quality Control & MSDS

製品説明

  • Compare DNA-PK Inhibitors
    DNA-PK製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 NU7441 (KU-57788)は、14nMのIC50による非常に強力で選択的なDNAPK阻害剤です。
ターゲット DNA-PK
IC50 14 nM [1]
In vitro試験 NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H1770 NXvI[4Y1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEKxOFMh|ryP NHz2ZotUSU6JRWK=
A172 NHjpcVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PteGlEPTB;MD6xOVMyPiEQvF2= NU\UVVhvW0GQR1XS
NCI-H526 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMki0NFch|ryP NXK5fnNFW0GQR1XS
HDLM-2 NWS0VpZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv3cFNKSzVyPUCuN|I{PDVizszN MlfxV2FPT0WU
HuO-3N1 NFXEWo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwNE[2N|Yh|ryP MUnTRW5ITVJ?
NCI-SNU-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrYSW9QUUN3ME2wMlYxQTl2IN88US=> MoDYV2FPT0WU
SK-N-AS NH;NPVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwNkKyNVYh|ryP M1rvc3NCVkeHUh?=
LoVo NE\TfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDPT2I2UUN3ME2wMlg3PzR7IN88US=> NI\IOFZUSU6JRWK=
LAMA-84 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XDVWlEPTB;MD65PFg{OyEQvF2= NHjweFZUSU6JRWK=
CTB-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHX0XWhKSzVyPUGuNVE2PDZizszN NF;LUHdUSU6JRWK=
KP-N-YS NV3JfmtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfCSYN6UUN3ME2xMlE1OjNzIN88US=> Mmq3V2FPT0WU
HH MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmruTWM2OD1zLkG4NFk{KM7:TR?= MWHTRW5ITVJ?
CHL-1 NHnOW5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj5coJ{UUN3ME2xMlIyOzZ6IN88US=> M1TwR3NCVkeHUh?=
NB7 M2G2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrQc|FKSzVyPUGuNlQ4PDVizszN NFXz[3RUSU6JRWK=
HL-60 NFPNXHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnUTWM2OD1zLkO4NVkh|ryP MUDTRW5ITVJ?
639-V Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHKZWJKSzVyPUGuOFQyOjhizszN M3XXcHNCVkeHUh?=
NCI-H1793 NIj6NFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG1W3pKSzVyPUGuOFU5PCEQvF2= MkXEV2FPT0WU
NEC8 MlXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwNUWzOUDPxE1? M3PtUXNCVkeHUh?=
PA-1 MkTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7xTWM2OD1zLkW4Nlk1KM7:TR?= NF7SVXhUSU6JRWK=
D-423MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoKzTWM2OD1zLk[5N|YyKM7:TR?= NVrX[YFoW0GQR1XS
NCI-H292 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j6bGlEPTB;MT63OFAyOyEQvF2= M4LNXnNCVkeHUh?=
SK-MEL-1 NH3MVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT0TWM2OD1zLke5OFc6KM7:TR?= NGXCO45USU6JRWK=
LB2241-RCC NY\0cZBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\icGlEPTB;Mj6xOFE1PiEQvF2= MkLPV2FPT0WU
SK-MEL-3 NFOwOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLCUZNuUUN3ME2yMlE3PDlizszN NETBeINUSU6JRWK=
MHH-PREB-1 NInBXZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXtV5VKSzVyPUKuNVY3ODlizszN NVrhblE2W0GQR1XS
BFTC-905 NW\hS4FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJwMU[2PFch|ryP NFPs[FdUSU6JRWK=
Ramos-2G6-4C10 M3W2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DxU2lEPTB;Mj6xPVkxQSEQvF2= MoLCV2FPT0WU
G-361 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPnTWM2OD1{LkKxOlgh|ryP M4PuRXNCVkeHUh?=
MOLT-4 M3TMOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfQTWM2OD1{LkKxPFg5KM7:TR?= MljFV2FPT0WU
DEL M4XzUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\EVWlEPTB;Mj6zOVU3PCEQvF2= M1LON3NCVkeHUh?=
MV-4-11 M3HUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEm4RmtKSzVyPUKuN|c{QSEQvF2= NEL5d4ZUSU6JRWK=
SK-NEP-1 NWDGSml2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmq4TWM2OD1{LkO4O|g{KM7:TR?= MkXMV2FPT0WU
RS4-11 NUTOdYpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJwNU[wNlMh|ryP MVTTRW5ITVJ?
HuH-7 Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHveJZnUUN3ME2yMlU3PzB{IN88US=> NGjCO|hUSU6JRWK=
A101D MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17NeWlEPTB;Mj62NVM{QCEQvF2= NX3sTJVuW0GQR1XS
KG-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLLUJlZUUN3ME2yMlY4QTJ2IN88US=> M{T2OHNCVkeHUh?=
KALS-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJwNkm2N|Mh|ryP NX\6ephnW0GQR1XS
VMRC-RCZ NFrGWldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXL2NpI6UUN3ME2yMlc4OzJ6IN88US=> NFTpc2tUSU6JRWK=
SK-UT-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjzNW5KSzVyPUOuNVU{OSEQvF2= MkHPV2FPT0WU
SW962 NELIT4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTNwMkCzOVIh|ryP NGTwO2VUSU6JRWK=
DBTRG-05MG M{HUZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfWbmhKSzVyPUOuNlgxQDVizszN NHnTd|FUSU6JRWK=
PANC-08-13 M{jLWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL1TWM2OD1|LkSxNlc5KM7:TR?= M1PhZnNCVkeHUh?=
QIMR-WIL MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTNwNEGzOFEh|ryP NHftfY5USU6JRWK=
SK-MEL-30 Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDZTWM2OD1|LkSyOVk5KM7:TR?= M4fKe3NCVkeHUh?=
697 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTUUINKSzVyPUOuOFQ6QTNizszN MlHRV2FPT0WU
NY NYPXWoxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTNwNEWwNlIh|ryP NEDPNWtUSU6JRWK=
ES7 M3LkSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjUNFhKSzVyPUOuOFY4OjlizszN NYDtN2lWW0GQR1XS
JVM-3 NHHYPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zKZ2lEPTB;Mz60PFA4PyEQvF2= M3mx[HNCVkeHUh?=
U031 M1frSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PINWlEPTB;Mz61PVM3QCEQvF2= M3XLUHNCVkeHUh?=
BHT-101 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PYc2lEPTB;Mz61PVk5PSEQvF2= NGixO4dUSU6JRWK=
8305C NWO3[G5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33EeWlEPTB;Mz62NVc{PiEQvF2= NGr4epFUSU6JRWK=
MG-63 M2X5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrFWVlKSzVyPUOuOlI3PzZizszN Mn7CV2FPT0WU
NOS-1 NYLwRZdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHxTWM2OD1|Lk[1N|EzKM7:TR?= NH;HRnJUSU6JRWK=
YH-13 MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX6flNKSzVyPUOuPFcyQDlizszN MnLRV2FPT0WU
LXF-289 NVTDU3NtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTNwOUGwOFEh|ryP NV64SohxW0GQR1XS
GOTO MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3RTWM2OD1|LkmxOFkh|ryP MlrHV2FPT0WU
EKVX M4rjXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1WwfmlEPTB;ND6yNlUzPCEQvF2= MonUV2FPT0WU
CAL-51 NWfhNG1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf1NWdKSzVyPUSuNlQ5PTRizszN M1zYZXNCVkeHUh?=
AN3-CA NXnsVWhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFraSWRKSzVyPUSuNlU5OTNizszN Mnf4V2FPT0WU
IA-LM Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPNTWM2OD12LkK3PVM2KM7:TR?= MXrTRW5ITVJ?
KU-19-19 NFraRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PQ[WlEPTB;ND6zNlkzOSEQvF2= M1W3RnNCVkeHUh?=
A704 NXfOOlRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP4OIJKSzVyPUSuOFA5QDhizszN NGXNU|BUSU6JRWK=
RH-18 NVrDN4lWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\LPWlEPTB;ND60OFk2OyEQvF2= MkTqV2FPT0WU
IST-MEL1 M3XSRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\FVY1KSzVyPUSuOVgzPjNizszN NW\jbIIxW0GQR1XS
LU-134-A MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPyTWM2OD12LkW5Olg2KM7:TR?= NIr2dmZUSU6JRWK=
SF126 NH;EXXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTRwNkC3NVUh|ryP MYjTRW5ITVJ?
EFO-27 M3;i[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jiVGlEPTB;ND62OlUzPSEQvF2= NWDQNWgxW0GQR1XS
SN12C M2PxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;ETWM2OD12LkexPFk5KM7:TR?= NIjDUlRUSU6JRWK=
L-363 NYfY[GJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTRwN{exNVYh|ryP NEXPRplUSU6JRWK=
MEL-HO NUjGW|V2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTRwN{e5PFkh|ryP NXfzVY0yW0GQR1XS
TYK-nu MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTRwOECxNlgh|ryP NGXiXFRUSU6JRWK=
MDA-MB-415 M{XmVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTVwMECzNVQh|ryP M3rlV3NCVkeHUh?=
HCC70 Mn35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjFOW9KSzVyPUWuNFM6OzlizszN MYDTRW5ITVJ?
IGROV-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHWTWM2OD13LkK1NlkzKM7:TR?= MU\TRW5ITVJ?
NCI-H1355 Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi4TWM2OD13LkK5OkDPxE1? NVHRZZQxW0GQR1XS
23132-87 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nLbGlEPTB;NT6zNlAzPCEQvF2= NHjWOodUSU6JRWK=
NB69 Mn;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTVwM{K0NkDPxE1? MU\TRW5ITVJ?
HSC-2 M{nRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTVwNEG3O|Mh|ryP M1K4V3NCVkeHUh?=
KYSE-410 MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LzZmlEPTB;NT60O|Y{PiEQvF2= NFfVbldUSU6JRWK=
GCIY NEPiOWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnTV3pKSzVyPUWuOVE{PzhizszN MojLV2FPT0WU
A427 M1;aUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7I[4FyUUN3ME21MlU{PjZzIN88US=> NXTwdlJpW0GQR1XS
ChaGo-K-1 NVnnTnpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTVwNU[1PVkh|ryP MYnTRW5ITVJ?
PFSK-1 M3[1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4m0W2lEPTB;NT62NlE6PCEQvF2= M3XON3NCVkeHUh?=
MLMA MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzF[G5KSzVyPUWuPFM3ODZizszN MXzTRW5ITVJ?
RVH-421 MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;TTWlEPTB;Nj6wO|M{QCEQvF2= NWniXWQ{W0GQR1XS
LB1047-RCC MkT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTZwMUe1NlIh|ryP NICxcJNUSU6JRWK=
MHH-NB-11 M4Hldmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrqNFY3UUN3ME22MlMzPzJzIN88US=> MkHKV2FPT0WU
J-RT3-T3-5 NF\5cIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTZwNkOyPVEh|ryP M{nscnNCVkeHUh?=
UM-UC-3 MmPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzNS5FKSzVyPU[uOlQ{OzRizszN NV\pN2JiW0GQR1XS
IST-SL1 M4rte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rnfWlEPTB;Nj62PVM3QSEQvF2= NULGWFR7W0GQR1XS
NB14 MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTZwN{m3OlEh|ryP MkX4V2FPT0WU
NBsusSR NXfYTGJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\nfpdMUUN3ME22MlgzPTB{IN88US=> MUPTRW5ITVJ?
D-263MG M33kWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3Qe4xXUUN3ME22MlkyODZ6IN88US=> MYrTRW5ITVJ?
NCI-H2347 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXucG5KSzVyPU[uPVMzOTNizszN NUXufZpqW0GQR1XS
ES8 NUiwXmxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnWTWM2OD14Lkm3OVg5KM7:TR?= NXfqW4kxW0GQR1XS
786-0 NWP5fWlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nL[2lEPTB;Nz6wPVc5PiEQvF2= M1XrZnNCVkeHUh?=
EPLC-272H M{HTNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnK2TWM2OD15LkG2NlQ3KM7:TR?= Mo\5V2FPT0WU
CAPAN-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWO5XJRGUUN3ME23MlI1OzV7IN88US=> NWfmVlN2W0GQR1XS
NCI-H82 MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPBdYpKSzVyPUeuNlY3PTlizszN NIjrOIZUSU6JRWK=
G-402 NHLQOGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\QTWM2OD15LkOwNFUyKM7:TR?= MV;TRW5ITVJ?
SW982 NUXIfoNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX0ZnZKSzVyPUeuN|AzODNizszN NIPZdVFUSU6JRWK=
OVCAR-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3vdZJ3UUN3ME23MlMyOzJ6IN88US=> MkT2V2FPT0WU
KARPAS-299 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPxcIFKSzVyPUeuN|I3OjJizszN NGHEOolUSU6JRWK=
MIA-PaCa-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTdwM{[4NlMh|ryP NFfqTlRUSU6JRWK=
AU565 NGP3XZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTdwNUm4N|Mh|ryP NVrGSms2W0GQR1XS
GAMG M4PPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7rSnRrUUN3ME23MlY1OTNzIN88US=> M13QPXNCVkeHUh?=
HuO9 Mn3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTdwN{G3OFMh|ryP NYHuPVBrW0GQR1XS
ACN NHjMOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTdwN{SzN{DPxE1? NV74eWRWW0GQR1XS
RO82-W-1 MoKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTdwN{S1N|Mh|ryP MYrTRW5ITVJ?
NKM-1 NI\GPJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHrR4pyUUN3ME23Mlc1QTV3IN88US=> MonTV2FPT0WU
CAL-12T NGrSU5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTdwOUSzOVIh|ryP MlflV2FPT0WU
FADU MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fOXWlEPTB;OD6wN|Y2PCEQvF2= Mmm0V2FPT0WU
NCI-H28 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW0Zo1pUUN3ME24MlE3QTZ{IN88US=> MX\TRW5ITVJ?
LCLC-97TM1 Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j4dmlEPTB;OD6yNVEzOiEQvF2= M1;ZUHNCVkeHUh?=
CHP-134 NIPYU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS5WnRKSzVyPUiuNlQyQDVizszN NXz2[nBVW0GQR1XS
HT-1080 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTsTWM2OD16LkK1NFk{KM7:TR?= Ml7qV2FPT0WU
PC-3 NXvhR5B3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\ZTWM2OD16LkK3N|kzKM7:TR?= NEPVTnhUSU6JRWK=
SNU-449 M3TPUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rRO2lEPTB;OD6yO|k{KM7:TR?= M33tW3NCVkeHUh?=
VA-ES-BJ NGq0SoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzLTWM2OD16LkO0Olg3KM7:TR?= NFLWVWFUSU6JRWK=
HT MmjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRThwM{[0PUDPxE1? MkW4V2FPT0WU
HOS NHLEdnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHE[4ZKUUN3ME24MlM4PTh7IN88US=> M{jLOnNCVkeHUh?=
KNS-62 M1Wy[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGn3bGtKSzVyPUiuN|c4PjJizszN MnPSV2FPT0WU
OAW-42 NFeyUG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfTPGpGUUN3ME24Mlk2QTZ2IN88US=> NGDRem1USU6JRWK=
A549 Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLuW4RKSzVyPUmuNFk3OTJizszN NWTFbI56W0GQR1XS
CAKI-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzvR|BKSzVyPUmuNVY3OSEQvF2= M4DJcnNCVkeHUh?=
HCC1937 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrnSG1UUUN3ME25MlY6QDZ3IN88US=> NILhSIZUSU6JRWK=
GI-ME-N Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTlwN{CxN|ch|ryP NFXSNYJUSU6JRWK=
DU-4475 NGrHeFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDCTWM2OD17Lkm2PVM6KM7:TR?= MXfTRW5ITVJ?
EM-2 MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlyyTWM2OD1zMD6yOFI3KM7:TR?= NVfQTotVW0GQR1XS
NCI-H1755 Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX6we3JjUUN3ME2xNE4zPDJ6IN88US=> Ml\FV2FPT0WU
NCI-H1437 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXtTWM2OD1zMD61O|I2KM7:TR?= M3fZdnNCVkeHUh?=
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A2058 NVv6SZJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7hTWM2OD1zMD62OFA1KM7:TR?= MV7TRW5ITVJ?
BPH-1 NFjvW5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWC2ZohiUUN3ME2xNE44OTR3IN88US=> NGHLPY9USU6JRWK=
NB5 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEe4W21KSzVyPUGwMlc2PTlizszN M2CzeXNCVkeHUh?=
G-401 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjSZW1KSzVyPUGwMlc3OjZizszN MkLHV2FPT0WU
CAL-72 NWXwNJRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jONGlEPTB;MUCuPFA6PCEQvF2= NF32d5VUSU6JRWK=
SK-MEL-28 NXXnboViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjoVJZzUUN3ME2xNE45OjB{IN88US=> M2G2NHNCVkeHUh?=
C32 NIPDfHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe3Z3ZxUUN3ME2xNE45OzR5IN88US=> MYjTRW5ITVJ?
NCI-H1155 NHHSRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTLTJBIUUN3ME2xNE45Ozd4IN88US=> NIjPdW1USU6JRWK=
BB49-HNC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjCcnpKSzVyPUGwMlg2QDZizszN M1PocnNCVkeHUh?=
GMS-10 MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXMNoVKSzVyPUGwMlg6PzFizszN NFP4fJdUSU6JRWK=
K5 M3HwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFyLkmwO|Eh|ryP M2rxU3NCVkeHUh?=
OS-RC-2 M4fjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zPOWlEPTB;MUGuNFU2QSEQvF2= NHnacVhUSU6JRWK=
HTC-C3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFzLkC3NVQh|ryP M2G2[HNCVkeHUh?=
LB996-RCC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTFzLkC3NlMh|ryP MV\TRW5ITVJ?
NCI-H1563 NVzre5ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFzLkGwNVEh|ryP MX\TRW5ITVJ?
CAL-54 NY\CWmtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXW4[nFqUUN3ME2xNU41QDFzIN88US=> MYHTRW5ITVJ?
WM-115 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTmOFlKSzVyPUGxMlY5OjRizszN MXLTRW5ITVJ?
COLO-684 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LHVWlEPTB;MUGuO|I3PyEQvF2= NYj1VXRHW0GQR1XS
HOP-62 Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\aXnlKSzVyPUGxMlc2ODhizszN M1HNUXNCVkeHUh?=
NCI-H650 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUj0b3ZCUUN3ME2xNU45QTZzIN88US=> NY\nSGZpW0GQR1XS
TE-11 M1;Lb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LqfWlEPTB;MUGuPVMyPSEQvF2= MXHTRW5ITVJ?
COLO-679 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDBc3pKSzVyPUGxMlk1PiEQvF2= MW\TRW5ITVJ?
FTC-133 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvQTYNKSzVyPUGyMlAxPzZizszN MlLEV2FPT0WU
D-283MED MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\iN|lKSzVyPUGyMlA2PjlizszN M4HvdXNCVkeHUh?=
SK-PN-DW MnHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTF{LkG5NFIh|ryP Mn61V2FPT0WU
BALL-1 NWfNTYVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nWPGlEPTB;MUKuNlY3OiEQvF2= M3rxdXNCVkeHUh?=
GT3TKB NX3zdW9KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDSboVKSzVyPUGyMlMxPzRizszN Ml;iV2FPT0WU
HOP-92 NXjmRZRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfTRodKSzVyPUGyMlUzOzNizszN MWnTRW5ITVJ?
M14 M4\acmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[2TWM2OD1zMz6wN|M2KM7:TR?= NYPIUZN2W0GQR1XS
SKG-IIIa NViweGRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHXV5J4UUN3ME2xN{4xPTV2IN88US=> NYjWW4dSW0GQR1XS
Becker MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTF|LkC1PEDPxE1? NE\3dpJUSU6JRWK=
ES5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\CTWM2OD1zMz6xN|U3KM7:TR?= Ml\JV2FPT0WU
NCI-H2030 M2nIb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XkT2lEPTB;MUOuNlA3OiEQvF2= NYPMOox5W0GQR1XS
SNU-423 M2PhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonETWM2OD1zMz6zPFEh|ryP NFi0W2NUSU6JRWK=
CP50-MEL-B M2HWPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\P[nJKSzVyPUGzMlYzOzJizszN NEjk[YNUSU6JRWK=
NCI-H1092 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGq3TYlKSzVyPUGzMlc1PzVizszN M1HVcHNCVkeHUh?=
8-MG-BA NUCwdlRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3vTWM2OD1zMz63OVE{KM7:TR?= MkSzV2FPT0WU
CAL-27 NWWzNoQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHHVFJKSzVyPUG0MlA4OjdizszN NF[2XGpUSU6JRWK=
AGS MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3joS2lEPTB;MUSuNVMyQSEQvF2= NFHuZWdUSU6JRWK=
MZ2-MEL MnTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTF2LkG0PFgh|ryP Mk[2V2FPT0WU
BFTC-909 Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jOVmlEPTB;MUSuOVA2PSEQvF2= M3PCfHNCVkeHUh?=
D-566MG MmP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnueIY1UUN3ME2xOE44PzB4IN88US=> NYTrXZN[W0GQR1XS
MZ7-mel MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7vXphSUUN3ME2xOU4yODZ5IN88US=> NH3YVnhUSU6JRWK=
TE-5 NIniSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jwXGlEPTB;MUWuNlM{OyEQvF2= MXrTRW5ITVJ?
647-V Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH4TWM2OD1zNT6yO|A2KM7:TR?= MljvV2FPT0WU
DMS-114 NUnCcJNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XPVmlEPTB;MUWuN|I6OSEQvF2= NGXhd5VUSU6JRWK=
ME-180 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTPXIhKSzVyPUG1MlQ4QDNizszN MkjkV2FPT0WU
MS-1 M1LWNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXEUGZTUUN3ME2xOU42PjJ|IN88US=> MoHVV2FPT0WU
NUGC-3 NX7udmxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nMVWlEPTB;MUWuOlI1PSEQvF2= NYL2TGtNW0GQR1XS
GB-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HnTmlEPTB;MUWuOlQ{PyEQvF2= Mn3GV2FPT0WU
LOXIMVI MmLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHrXVU3UUN3ME2xOU45QTF7IN88US=> MWHTRW5ITVJ?
NCI-H1304 NELHcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XYfWlEPTB;MUWuPFkzQCEQvF2= MVrTRW5ITVJ?
KURAMOCHI MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HrcWlEPTB;MUWuPVcyKM7:TR?= NWrIcIV4W0GQR1XS
SW1783 NVrD[ppmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTw[mdKSzVyPUG2MlA6QTNizszN M2XEcHNCVkeHUh?=
EGI-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T6bmlEPTB;MU[uOVM3PSEQvF2= MVfTRW5ITVJ?
KGN MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG2SGt[UUN3ME2xOk42PTh4IN88US=> M33YbXNCVkeHUh?=
PANC-03-27 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELxR3ZKSzVyPUG2Mlc3PjJizszN MkTwV2FPT0WU
RH-1 NG\BcFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\hXGlEPTB;MU[uPFI2KM7:TR?= NYjHdoxKW0GQR1XS
HT-1376 NFr0dmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPYVJFrUUN3ME2xOk45PDR4IN88US=> M{TZdXNCVkeHUh?=
ZR-75-30 M{fsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvkTWM2OD1zNj65N|YyKM7:TR?= M4XBZXNCVkeHUh?=
TI-73 NHjCe|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjLVWVKSzVyPUG2Mlk1ODhizszN M3\PXXNCVkeHUh?=
TK10 NEHOU2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIniPIdKSzVyPUG3MlAxPzlizszN NG\TTJRUSU6JRWK=
SW684 NVfBU5N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILnSIlKSzVyPUG3MlAyPTRizszN MY\TRW5ITVJ?
RPMI-8866 NHPFZZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjSb2JwUUN3ME2xO{4xPjl7IN88US=> NEe4SYRUSU6JRWK=
LNCaP-Clone-FGC M37jWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF5LkWyNFEh|ryP MoC4V2FPT0WU
NCI-H2291 MoPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPSZm5KSzVyPUG4MlQ{PDVizszN NUjzZmJVW0GQR1XS
T47D MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvv[VZ{UUN3ME2xPE41QDhizszN M1[5fnNCVkeHUh?=
A204 NH7CNZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTQTWM2OD1zOD61OFUzKM7:TR?= NEGwVJZUSU6JRWK=
HT-144 NVnrNXF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF6Lke0Nlch|ryP NUTTWYxyW0GQR1XS
MDA-MB-361 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrGTWM2OD1zOT6wO|E1KM7:TR?= MV\TRW5ITVJ?
HCC1806 NFWzeJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfJZZJKUUN3ME2xPU4yPTlzIN88US=> MnPqV2FPT0WU
NCI-H596 NVLEeJlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDEcHdjUUN3ME2xPU43OzlzIN88US=> NHHjVHJUSU6JRWK=
K-562 M3:1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mme0TWM2OD1zOT64PVI3KM7:TR?= M3XvSnNCVkeHUh?=
D-336MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XSOmlEPTB;MUmuPVMzOiEQvF2= NITacHlUSU6JRWK=
SK-MEL-2 NWXrelFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvKTWM2OD1{MD6xOVU6KM7:TR?= NFX1[lhUSU6JRWK=
HEC-1 NYCxTW1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XaOmlEPTB;MkCuOFk4QCEQvF2= MYDTRW5ITVJ?
EW-13 NXnhenhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnMdZB3UUN3ME2yNE42PDR|IN88US=> MmTjV2FPT0WU
Hs-578-T NGDndWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz1TWM2OD1{MD61OVg{KM7:TR?= NXu5fpNHW0GQR1XS
SJSA-1 MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[4TWM2OD1{MD61Olg5KM7:TR?= MofSV2FPT0WU
RCC10RGB MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHKSFZmUUN3ME2yNE43PzF7IN88US=> NW\SRZR6W0GQR1XS
LAN-6 NHHzeXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJzLkCzPVYh|ryP NHzz[oJUSU6JRWK=
NCI-H1048 M4fsbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7YOXpKSzVyPUKxMlIzPThizszN MnXPV2FPT0WU
CW-2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\qSXB3UUN3ME2yNU4zPzB3IN88US=> NH7xNI5USU6JRWK=
HCC2157 NYPTUFlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJzLkO2JO69VQ>? M1:xO3NCVkeHUh?=
EW-22 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\hR2pKSzVyPUKxMlM4PiEQvF2= MknzV2FPT0WU
A253 NHzReZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXhc2NSUUN3ME2yNU41PDhzIN88US=> MlWwV2FPT0WU
BE-13 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJzLk[xNVMh|ryP M1XmOHNCVkeHUh?=
KINGS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT3RmpUUUN3ME2yNU43OzF4IN88US=> NUL5VYFoW0GQR1XS
ETK-1 NUDuOpJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJzLkixOVIh|ryP NUnlXYdlW0GQR1XS
NCI-H2452 NGLZZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW4TWM2OD1{MT64OlQ4KM7:TR?= MnjTV2FPT0WU
HPAF-II M3q5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnVTWM2OD1{MT64PVI{KM7:TR?= M13ZU3NCVkeHUh?=
D-542MG NXrNRVZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJzLkmwOlkh|ryP MWHTRW5ITVJ?
NCI-H630 NWDGelRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJ{LkCyPVYh|ryP MmLWV2FPT0WU
TGBC11TKB M4f6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHNeIh3UUN3ME2yNk4xPDlizszN NXTMfno5W0GQR1XS
BCPAP MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjxTWM2OD1{Mj62NVEh|ryP NY\kUW43W0GQR1XS
HLE NU\kS3Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzvVmNRUUN3ME2yNk43QTdizszN MmDnV2FPT0WU
NCI-H727 NXXlcYI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoT1TWM2OD1{Mj63N|Uh|ryP NXPPTWVOW0GQR1XS
RD MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\OfGlEPTB;MkKuO|UyQCEQvF2= Mk[5V2FPT0WU
NCI-H522 NGewXHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ{Lki0N|Eh|ryP MUjTRW5ITVJ?
CGTH-W-1 M2L1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i4TWlEPTB;MkOuNFY1OSEQvF2= M2fYTnNCVkeHUh?=
SK-LU-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHTXXBKSzVyPUKzMlQ3QDNizszN MmTWV2FPT0WU
BB65-RCC NWCxOpRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\uSHVKSzVyPUKzMlc5PjNizszN MYnTRW5ITVJ?
HSC-3 NGjYdo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rEPWlEPTB;MkOuPFUzPyEQvF2= NIfISlVUSU6JRWK=
SK-MES-1 NFvnepZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ2LkCxOlEh|ryP MWjTRW5ITVJ?
DB M{TsSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXuTWM2OD1{ND6xNFI5KM7:TR?= NFvodI5USU6JRWK=
HO-1-N-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLQTWM2OD1{ND6zNFk{KM7:TR?= NEf0cI1USU6JRWK=
MKN1 MnH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU[zdW9vUUN3ME2yOE43QCEQvF2= MYXTRW5ITVJ?
MN-60 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPCVpRKSzVyPUK0Mlg2OTlizszN NHOyOZVUSU6JRWK=
8505C NF:xXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHKTWM2OD1{NT6xPFQ2KM7:TR?= NXXYdo1GW0GQR1XS
COLO-320-HSR MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ3LkKyNFgh|ryP NIDiWmpUSU6JRWK=
BB30-HNC NXvs[pYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTJ3LkK0PFMh|ryP NVvXbpZlW0GQR1XS
KM12 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7yTWM2OD1{NT61PFA4KM7:TR?= NGLlR5ZUSU6JRWK=
NB13 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJ3LkW4PVgh|ryP MkPqV2FPT0WU
HCC2998 NETVSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\FS2pOUUN3ME2yOk4xOjh|IN88US=> NGTB[pdUSU6JRWK=
U-118-MG NYntOpIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJ4LkC4NFgh|ryP MXPTRW5ITVJ?
NB10 NF2wVlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\PZWRKSzVyPUK2MlI{PCEQvF2= M2rWV3NCVkeHUh?=
SK-LMS-1 NVvNXFVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fZdmlEPTB;MkeuNFcxPCEQvF2= NGHtfpJUSU6JRWK=
SW1573 M4DQOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLOS5JKSzVyPUK3MlEyKM7:TR?= MV\TRW5ITVJ?
LB373-MEL-D M1TDZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[yUGRKSzVyPUK3MlEzQTRizszN NEDMdplUSU6JRWK=
DK-MG NV7xcIp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3SwU2lEPTB;MkeuNVgyPyEQvF2= M4XXVXNCVkeHUh?=
RMG-I MlHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PvOWlEPTB;MkeuNlAzQSEQvF2= MnnYV2FPT0WU
SW1088 MkjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7vdGNKSzVyPUK3MlUxPDJizszN NFnRUWVUSU6JRWK=
SK-OV-3 NH\1NnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJ5Lke1PVMh|ryP NVj2e2NUW0GQR1XS
KP-N-YN NVqx[4ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLrTWM2OD1{Nz64NFQ{KM7:TR?= MVHTRW5ITVJ?
RPMI-7951 Mlf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTJTWM2OD1{OD6yOFU3KM7:TR?= NYLsXIx7W0GQR1XS
CaR-1 NIPhSZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLyZWc{UUN3ME2yPE42PTh{IN88US=> MoriV2FPT0WU
MKN7 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1G3TWlEPTB;MkiuOVk3PCEQvF2= NIDOdZBUSU6JRWK=
CHP-212 NYXqZYdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f5c2lEPTB;MkiuO|QxOSEQvF2= NGnFeHpUSU6JRWK=
KYSE-450 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D5O2lEPTB;MkiuPFA6OSEQvF2= NYPzSWhiW0GQR1XS
RXF393 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz5UnFKUUN3ME2yPU4zQTB4IN88US=> MmP2V2FPT0WU
P30-OHK MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHZfYNKSzVyPUK5MlMxPDhizszN NXS2ZpZ[W0GQR1XS
Ca9-22 MkfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PIXmlEPTB;MkmuOFI6QSEQvF2= NV[1W49HW0GQR1XS
RT-112 NF\YdWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7UNVJKSzVyPUK5MlQ3OTFizszN MWfTRW5ITVJ?
ES1 NFjmT5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7mTVRKSzVyPUK5Mlg2PDRizszN NWLkS|E5W0GQR1XS
HCE-4 M1PWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7vblVKSzVyPUK5Mlg4QDZizszN MYLTRW5ITVJ?
AM-38 M4m3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fhemlEPTB;M{CuNFYxPiEQvF2= NYD6RmJpW0GQR1XS
AsPC-1 MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWO4PGhIUUN3ME2zNE45ODV|IN88US=> MX7TRW5ITVJ?
TE-9 M2OyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mne5TWM2OD1|MD64O|M4KM7:TR?= MXvTRW5ITVJ?
HuP-T4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\VUJVvUUN3ME2zNE46PjN6IN88US=> Mo\ZV2FPT0WU
LB2518-MEL MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HkPWlEPTB;M{GuNFc1PCEQvF2= M4DxTHNCVkeHUh?=
NCI-H1703 NH3UeWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle0TWM2OD1|MT6wPVA2KM7:TR?= M3zQWnNCVkeHUh?=
NCI-H2228 NXnudmFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkKzTWM2OD1|MT60OlUyKM7:TR?= MljhV2FPT0WU
SCC-4 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fue2lEPTB;M{GuPVE5OSEQvF2= M2L1TnNCVkeHUh?=
KNS-81-FD NEXINY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M374RmlEPTB;M{KuNFEzQCEQvF2= M3zHeXNCVkeHUh?=
NTERA-S-cl-D1 NWrXdVBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PsPGlEPTB;M{KuNFc{QSEQvF2= NWPyXIY5W0GQR1XS
Daoy MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTN{LkC4N|gh|ryP NUjwN2ZGW0GQR1XS
ES4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHH[nBKSzVyPUOyMlM6OjJizszN M2X4N3NCVkeHUh?=
MHH-ES-1 M{ThXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3izbmlEPTB;M{KuOFg4OiEQvF2= MYjTRW5ITVJ?
C-33-A MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\nTWM2OD1|Mj63O|I5KM7:TR?= NWXte|ZDW0GQR1XS
BHY MlTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLuXG5KSzVyPUOyMlk1QTVizszN NIGzOmlUSU6JRWK=
Detroit562 NEK3N5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\Mc3ZYUUN3ME2zN{43PjV5IN88US=> M2rLfHNCVkeHUh?=
EW-1 NVPMS5ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTN|LkmzNlIh|ryP M{iwSnNCVkeHUh?=
NCI-H1395 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S0dWlEPTB;M{SuNFc6QSEQvF2= NHf5SGNUSU6JRWK=
KM-H2 M1LXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzTTWM2OD1|Nj60O|Q{KM7:TR?= MUnTRW5ITVJ?
NCI-H520 NVvmflMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i4OWlEPTB;M{[uO|U1OSEQvF2= NH7BdYZUSU6JRWK=
D-392MG M2LD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTN5LkOzOFQh|ryP NXTEdWViW0GQR1XS
NOMO-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTN5LkiwPFkh|ryP M1G1Z3NCVkeHUh?=
TE-6 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL0T2xyUUN3ME2zPE4yOjRizszN NFzYc2tUSU6JRWK=
HT-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrhTlBKSzVyPUO4MlQ1OzZizszN NUHMU4ZFW0GQR1XS
RPMI-8226 NEL2c4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTN6Lkm1NVkh|ryP M1jvcHNCVkeHUh?=
U251 MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT2[4w2UUN3ME2zPU4xOTJ2IN88US=> NIfVN21USU6JRWK=
GCT NVvHSFd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xje2lEPTB;M{muNVg2OiEQvF2= NX7uO45EW0GQR1XS
A431 M{HKcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTN7LkG4PVQh|ryP NHW1UmtUSU6JRWK=
TE-12 NV7kUWl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X4SWlEPTB;M{muNlQ1QCEQvF2= NYnDZWJHW0GQR1XS
HMV-II MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLkTWM2OD1|OT61NFQ4KM7:TR?= M4j5SXNCVkeHUh?=
IST-MES1 NV2wOpBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTRyLkG1NFIh|ryP NWrrWJRyW0GQR1XS
SW13 NXnLcoQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fTeGlEPTB;NECuOVE6KM7:TR?= M{K2PHNCVkeHUh?=
SF295 NHHxblhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTRyLkiwOlYh|ryP NYDCVmtCW0GQR1XS
MDA-MB-157 NF;YZWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1izV2lEPTB;NECuPVQ3OiEQvF2= MknZV2FPT0WU
TE-1 M3jmSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzCTWM2OD12MT64O|E1KM7:TR?= MV7TRW5ITVJ?
HuCCT1 MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M122ZmlEPTB;NEKuOVI5QSEQvF2= M1vJW3NCVkeHUh?=
KYSE-510 Ml63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTR|LkG3OVQh|ryP M1ezWXNCVkeHUh?=
NCI-H358 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LlcWlEPTB;NESuNFMxPCEQvF2= NVrxeYlSW0GQR1XS
SW900 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3q3S2lEPTB;NESuNFc2QCEQvF2= NITrXXRUSU6JRWK=
CAS-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTR2LkC5PVEh|ryP M4LBO3NCVkeHUh?=
TE-8 NUXNXXlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TXcWlEPTB;NESuOVY2QCEQvF2= M1;kTnNCVkeHUh?=
P12-ICHIKAWA NF32cYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\nTWM2OD12ND62NVEzKM7:TR?= Mlm1V2FPT0WU
YKG-1 NV;pWWpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLzTWM2OD12ND63PFEh|ryP NH3udFBUSU6JRWK=
SNU-C2B NWXmb2k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XaVGlEPTB;NESuO|kxOyEQvF2= M1vZb3NCVkeHUh?=
LCLC-103H MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTNZZhKSzVyPUS0Mlg4ODNizszN MVrTRW5ITVJ?
U-87-MG MmDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGi0TmlKSzVyPUS1MlExOjJizszN NXXLXYtFW0GQR1XS
HAL-01 MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\1eoxHUUN3ME20OU4yOzd7IN88US=> NWH3N3N6W0GQR1XS
OVCAR-8 NI\3bG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTtNlhsUUN3ME20OU4{PTZ2IN88US=> NHnKPIdUSU6JRWK=
KYSE-150 M2\YUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLOTWM2OD12Nz6xNFUzKM7:TR?= NGXNflhUSU6JRWK=
OE33 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTR5LkG0Nlkh|ryP MXjTRW5ITVJ?
CAL-62 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTR5LkSwOlgh|ryP M2DFVXNCVkeHUh?=
TCCSUP MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HFN2lEPTB;NEeuOlI3PCEQvF2= MlrtV2FPT0WU
H4 NIj5ZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvGfm5KSzVyPUS3MlY3OjFizszN NWnDOIxXW0GQR1XS
CP66-MEL Mne3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTR6LkC3NFQh|ryP MVzTRW5ITVJ?
SNB75 M1O3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTR6LkG4O|Qh|ryP MUHTRW5ITVJ?
Mo-T MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;MNVlKSzVyPUS4MlI4QSEQvF2= MlHJV2FPT0WU
BT-549 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7veoJ5UUN3ME20PE4{PzJ7IN88US=> Ml73V2FPT0WU
IGR-1 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXaT|BKSzVyPUS4MlY3PDVizszN M2DWbXNCVkeHUh?=
NCI-H1299 NIT6WFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3MeHNMUUN3ME20PE44OjR6IN88US=> NXezRWF2W0GQR1XS
ALL-PO NVTDfHhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jPVWlEPTB;NEmuPVI3QCEQvF2= NWHsRoZVW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]
臨床試験
特集

プロトコル (参考用のみ)

細胞アッセイ: [2]

細胞株 SW620, LoVo, V3-YAC and V3 cells
濃度 0.5 μM or 1 μM
反応時間 17 hours
実験の流れ The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.

動物実験: [2]

動物モデル Female rude mice bearing SW620 xenografts
製剤 Sterile 0.9% sodium chloride solution
投薬量 10 mg/kg
投与方法 Intraperitoneally administrated

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download NU7441 (KU-57788) SDF
分子量 413.49
化学式

C25H19NO3S

CAS No. 503468-95-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 3 mg/mL (7.25 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

カスタマーフィードバック (4)


Click to enlarge
Rating
Source Nucleic Acids Res, 2013, 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck
Method EU Immunofluorescence
Cell Lines A2780 ovarian cancer cells
Concentrations 1 uM
Incubation Time 1 h
Results It performed similar experiments using specific inhibitors of DNA-PK. Treatment with Nu7026 or Nu7441 before cisplatin significantly prevented inhibition of rRNA synthesis.

Click to enlarge
Rating
Source Nucleic Acids Res, 2013, 41, 10157-69. NU7441 (KU-57788) purchased from Selleck
Method Confocal immunostaining
Cell Lines 293T
Concentrations
Incubation Time 30min ,60min
Results the number of IRIFs was reduced significantly in p18CycE-expressing HEK 293T cells compared with parental cells. Pharmacological inhibition of ATM with KU55933 Revealed that S25-53BP1 phosphorylation was ATM-dependent in these cells as IRIFs of S25-53BP1 were abolished in both parental, as well as p18CycE-expressing cells.

Click to enlarge
Rating
Source Toxicol Sci, 2014, 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck
Method Western blot
Cell Lines H460 cells
Concentrations 1, 3, 10 uM
Incubation Time 1 h
Results It tested 3 concentrations of 2 DNAPK inhibitors (NU7026 and NU7441) for their off-target effects on ATM and ATR signaling in camptothecin-exposed cells. We found that only the highest dose of 60 uM NU7026 clearly diminished ATR activity as evidenced by a lower CHK1 phosphorylation. All doses of both inhibitors eliminated activating autophosphorylation of DNAPK at Ser2056.

Click to enlarge
Rating
Source Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck
Method
Cell Lines A549 cells
Concentrations 0-10 μM
Incubation Time 3 h
Results NU-7441 treatment resulted in a reduction of AKT phosphorylation.

文献中の引用 (14)

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    CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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