NU7441 (KU-57788) 化学構造
分子量: 413.49

高品質保証

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Quality Control & MSDS

製品説明

  • Compare DNA-PK Inhibitors
    DNA-PK製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 NU7441 (KU-57788)は、14nMのIC50による非常に強力で選択的なDNAPK阻害剤です。
ターゲット DNA-PK
IC50 14 nM [1]
In vitro試験 NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H1770 M1jVVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEKxOFMh|ryP NIPNd3JUSU6JRWK=
A172 NFqzWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS0ZYFKSzVyPUCuNVU{OTZizszN MWjTRW5ITVJ?
NCI-H526 NUCzfVFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMki0NFch|ryP MXHTRW5ITVJ?
HDLM-2 NYPMN5p2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPsVYlRUUN3ME2wMlMzOzR3IN88US=> NXGwW2FTW0GQR1XS
HuO-3N1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTVXG1EUUN3ME2wMlQ3PjN4IN88US=> MlPlV2FPT0WU
NCI-SNU-1 NX3udZFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLjTWM2OD1yLk[wPVk1KM7:TR?= M{fFenNCVkeHUh?=
SK-N-AS MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fkT2lEPTB;MD62NlIyPiEQvF2= Mn3rV2FPT0WU
LoVo NHzrbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\WWG9RUUN3ME2wMlg3PzR7IN88US=> M3nTSXNCVkeHUh?=
LAMA-84 NEXmZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjUTWM2OD1yLkm4PFM{KM7:TR?= M{nGZnNCVkeHUh?=
CTB-1 M2LHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TVR2lEPTB;MT6xNVU1PiEQvF2= MnXiV2FPT0WU
KP-N-YS NGrYNVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoroTWM2OD1zLkG0NlMyKM7:TR?= NGjqdlVUSU6JRWK=
HH M1PFUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL0cJlRUUN3ME2xMlE5ODl|IN88US=> MVzTRW5ITVJ?
CHL-1 NEDhdVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\XU5NKSzVyPUGuNlE{PjhizszN MlXOV2FPT0WU
NB7 NVK0[HZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\KNmlEPTB;MT6yOFc1PSEQvF2= MV7TRW5ITVJ?
HL-60 NGPmXoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTFwM{ixPUDPxE1? NGnXXVBUSU6JRWK=
639-V M{GwcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Lpb2lEPTB;MT60OFEzQCEQvF2= NXn4Rml5W0GQR1XS
NCI-H1793 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7NTWM2OD1zLkS1PFQh|ryP M1PhcXNCVkeHUh?=
NEC8 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HJWmlEPTB;MT61OVM2KM7:TR?= M3zGR3NCVkeHUh?=
PA-1 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HwOWlEPTB;MT61PFI6PCEQvF2= MmXnV2FPT0WU
D-423MG MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rteWlEPTB;MT62PVM3OSEQvF2= M1mxNnNCVkeHUh?=
NCI-H292 MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXUeoh3UUN3ME2xMlc1ODF|IN88US=> NVTIRWd4W0GQR1XS
SK-MEL-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFmwVWpKSzVyPUGuO|k1PzlizszN M1X2Z3NCVkeHUh?=
LB2241-RCC NXW1ZpEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O5WWlEPTB;Mj6xOFE1PiEQvF2= M4fGRXNCVkeHUh?=
SK-MEL-3 NXj6b28{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXWzbIl7UUN3ME2yMlE3PDlizszN MoXRV2FPT0WU
MHH-PREB-1 MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTXOGdDUUN3ME2yMlE3PjB7IN88US=> M1L1SXNCVkeHUh?=
BFTC-905 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTtPZpKSzVyPUKuNVY3QDdizszN NHPEZ|lUSU6JRWK=
Ramos-2G6-4C10 M1zaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELTXpNKSzVyPUKuNVk6ODlizszN NUDxVpN7W0GQR1XS
G-361 NVjxcVlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PBOmlEPTB;Mj6yNVY5KM7:TR?= NIrKOHNUSU6JRWK=
MOLT-4 M3HJRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjlT|l7UUN3ME2yMlIyQDh6IN88US=> Ml36V2FPT0WU
DEL NVjLdGJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnITWM2OD1{LkO1OVY1KM7:TR?= NIOzUYpUSU6JRWK=
MV-4-11 NVn0dpZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnPTWM2OD1{LkO3N|kh|ryP NE\ucYZUSU6JRWK=
SK-NEP-1 NInOUZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS0RYdYUUN3ME2yMlM5Pzh|IN88US=> NXnL[lBmW0GQR1XS
RS4-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLkTWM2OD1{LkW2NFI{KM7:TR?= MYHTRW5ITVJ?
HuH-7 M4nVbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPOTWM2OD1{LkW2O|AzKM7:TR?= MW\TRW5ITVJ?
A101D Ml3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJwNkGzN|gh|ryP NFzw[nlUSU6JRWK=
KG-1 Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELJVYtKSzVyPUKuOlc6OjRizszN NYHzNphKW0GQR1XS
KALS-1 NFr6T4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTJwNkm2N|Mh|ryP MnvLV2FPT0WU
VMRC-RCZ MnrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjmTWM2OD1{Lke3N|I5KM7:TR?= Mm[1V2FPT0WU
SK-UT-1 MmK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTNwMUWzNUDPxE1? NYK4R4kzW0GQR1XS
SW962 NVflPGdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWW2blN6UUN3ME2zMlIxOzV{IN88US=> MXXTRW5ITVJ?
DBTRG-05MG NXnFXGRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTNwMkiwPFUh|ryP NVjIWJhKW0GQR1XS
PANC-08-13 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTNwNEGyO|gh|ryP NFLQ[3JUSU6JRWK=
QIMR-WIL NVXO[oh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTNwNEGzOFEh|ryP MVvTRW5ITVJ?
SK-MEL-30 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK2UnJKSzVyPUOuOFI2QThizszN M2GwfnNCVkeHUh?=
697 NYfLOHo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\MdplLUUN3ME2zMlQ1QTl|IN88US=> NGTpTI1USU6JRWK=
NY NYLq[mpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nLVGlEPTB;Mz60OVAzOiEQvF2= M3nrfXNCVkeHUh?=
ES7 M3Prd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PRSGlEPTB;Mz60OlczQSEQvF2= NV\WfmR6W0GQR1XS
JVM-3 NGjBWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7lTWM2OD1|LkS4NFc4KM7:TR?= NGTOSYJUSU6JRWK=
U031 NYXqUXRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3aTXB{UUN3ME2zMlU6OzZ6IN88US=> NWDpOWV6W0GQR1XS
BHT-101 MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\sTWM2OD1|LkW5PVg2KM7:TR?= NHPZSVNUSU6JRWK=
8305C MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTNwNkG3N|Yh|ryP Mly1V2FPT0WU
MG-63 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWixN|VtUUN3ME2zMlYzPjd4IN88US=> M1y1cXNCVkeHUh?=
NOS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnyT49FUUN3ME2zMlY2OzF{IN88US=> NYqzWIk4W0GQR1XS
YH-13 NHixcG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfsS|BKSzVyPUOuPFcyQDlizszN MnTXV2FPT0WU
LXF-289 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\2TWM2OD1|LkmxNFQyKM7:TR?= M3vod3NCVkeHUh?=
GOTO MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTNwOUG0PUDPxE1? MlvFV2FPT0WU
EKVX MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rBOWlEPTB;ND6yNlUzPCEQvF2= MlvRV2FPT0WU
CAL-51 NESyeVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7vWmRKSzVyPUSuNlQ5PTRizszN MY\TRW5ITVJ?
AN3-CA MofZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTRwMkW4NVMh|ryP MWjTRW5ITVJ?
IA-LM MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\hPGlEPTB;ND6yO|k{PSEQvF2= NFv4Z|ZUSU6JRWK=
KU-19-19 M1faRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\SU5pKSzVyPUSuN|I6OjFizszN MlfXV2FPT0WU
A704 MlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33rSmlEPTB;ND60NFg5QCEQvF2= M1ixR3NCVkeHUh?=
RH-18 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDSTWM2OD12LkS0PVU{KM7:TR?= Mme3V2FPT0WU
IST-MEL1 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHJenFjUUN3ME20MlU5OjZ|IN88US=> NFjo[3BUSU6JRWK=
LU-134-A NICxRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTRwNUm2PFUh|ryP NGize|ZUSU6JRWK=
SF126 NWXvSox3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m4dmlEPTB;ND62NFcyPSEQvF2= M2HUXnNCVkeHUh?=
EFO-27 M4S1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzucYQ5UUN3ME20MlY3PTJ3IN88US=> NW\ITFNvW0GQR1XS
SN12C MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vHUWlEPTB;ND63NVg6QCEQvF2= NGntSIpUSU6JRWK=
L-363 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXLTWM2OD12Lke3NVE3KM7:TR?= M2e1Z3NCVkeHUh?=
MEL-HO NHvMPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj4WolKSzVyPUSuO|c6QDlizszN NH3GclBUSU6JRWK=
TYK-nu MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULpV5h4UUN3ME20MlgxOTJ6IN88US=> MYjTRW5ITVJ?
MDA-MB-415 NX\vS4J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTVwMECzNVQh|ryP M1HOXXNCVkeHUh?=
HCC70 M3HVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTVwMEO5N|kh|ryP NXLzemkzW0GQR1XS
IGROV-1 NVTLcI5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTVwMkWyPVIh|ryP NUfuNoo1W0GQR1XS
NCI-H1355 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfiO4NKSzVyPUWuNlk3KM7:TR?= M{fHUnNCVkeHUh?=
23132-87 MoDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nINGlEPTB;NT6zNlAzPCEQvF2= M2fJPXNCVkeHUh?=
NB69 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HXNGlEPTB;NT6zNlQzKM7:TR?= MXrTRW5ITVJ?
HSC-2 NH\WOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTVwNEG3O|Mh|ryP NFT1cIFUSU6JRWK=
KYSE-410 M2jxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfqTWM2OD13LkS3OlM3KM7:TR?= NX3jXmNGW0GQR1XS
GCIY M3G2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PVOmlEPTB;NT61NVM4QCEQvF2= NGfiUoVUSU6JRWK=
A427 NGG0XHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLzSod{UUN3ME21MlU{PjZzIN88US=> M2f3W3NCVkeHUh?=
ChaGo-K-1 NWfuW2V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrnbHBKSzVyPUWuOVY2QTlizszN NHfqd5dUSU6JRWK=
PFSK-1 MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojCTWM2OD13Lk[yNVk1KM7:TR?= MX3TRW5ITVJ?
MLMA MnrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCyW2VKSzVyPUWuPFM3ODZizszN NXrVdGVqW0GQR1XS
RVH-421 M3;3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2n5[mlEPTB;Nj6wO|M{QCEQvF2= NEXweJVUSU6JRWK=
LB1047-RCC NEfiPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHVPHNKSzVyPU[uNVc2OjJizszN MVrTRW5ITVJ?
MHH-NB-11 NXSyOlA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTZwM{K3NlEh|ryP NXLYZYtCW0GQR1XS
J-RT3-T3-5 NUPLXY56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTZwNkOyPVEh|ryP NH;GfnhUSU6JRWK=
UM-UC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTZwNkSzN|Qh|ryP NGSw[olUSU6JRWK=
IST-SL1 NVXQWFRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTZwNkmzOlkh|ryP NX\xTXl5W0GQR1XS
NB14 NHHVXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\aTGlEPTB;Nj63PVc3OSEQvF2= MkjVV2FPT0WU
NBsusSR NWHI[YJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTZwOEK1NFIh|ryP MlvFV2FPT0WU
D-263MG M12yc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLscGJKSzVyPU[uPVExPjhizszN MVPTRW5ITVJ?
NCI-H2347 MlvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTNWYhxUUN3ME22Mlk{OjF|IN88US=> MnjEV2FPT0WU
ES8 M2Hre2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7GSmtoUUN3ME22Mlk4PTh6IN88US=> M3Sz[XNCVkeHUh?=
786-0 NWn6fHlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;5c3FwUUN3ME23MlA6Pzh4IN88US=> NHvTfoFUSU6JRWK=
EPLC-272H NYLuNHhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTdwMU[yOFYh|ryP MljOV2FPT0WU
CAPAN-1 NHPyVYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTdwMkSzOVkh|ryP MY\TRW5ITVJ?
NCI-H82 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTdwMk[2OVkh|ryP NInHTmxUSU6JRWK=
G-402 MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rQUGlEPTB;Nz6zNFA2OSEQvF2= MmruV2FPT0WU
SW982 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHSfY5KSzVyPUeuN|AzODNizszN MoW4V2FPT0WU
OVCAR-4 Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXlR4RKSzVyPUeuN|E{OjhizszN M4PieXNCVkeHUh?=
KARPAS-299 NWn4dpQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3flNWlEPTB;Nz6zNlYzOiEQvF2= M2\lTnNCVkeHUh?=
MIA-PaCa-2 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPOTWM2OD15LkO2PFI{KM7:TR?= MXrTRW5ITVJ?
AU565 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\QOmlEPTB;Nz61PVg{OyEQvF2= NWrIb2YyW0GQR1XS
GAMG NGDwb|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\YTmlEPTB;Nz62OFE{OSEQvF2= NXThNnA5W0GQR1XS
HuO9 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnqZ2VKSzVyPUeuO|E4PDNizszN NF\UdW9USU6JRWK=
ACN NFHx[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHKycmhKSzVyPUeuO|Q{OyEQvF2= M2flOnNCVkeHUh?=
RO82-W-1 MlPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTdwN{S1N|Mh|ryP M3HnSXNCVkeHUh?=
NKM-1 NVfDfnNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTdwN{S5OVUh|ryP MYnTRW5ITVJ?
CAL-12T NV7E[HM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTdwOUSzOVIh|ryP M2n2cXNCVkeHUh?=
FADU NFTmdWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzyXJdKSzVyPUiuNFM3PTRizszN NYKybZpMW0GQR1XS
NCI-H28 NUnLdoJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;HTWM2OD16LkG2PVYzKM7:TR?= NEL0[I5USU6JRWK=
LCLC-97TM1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRThwMkGxNlIh|ryP Mnu4V2FPT0WU
CHP-134 NFHvTJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRThwMkSxPFUh|ryP M4nrdnNCVkeHUh?=
HT-1080 NUnIUJd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRThwMkWwPVMh|ryP NESxSIxUSU6JRWK=
PC-3 M2TVPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLkTWM2OD16LkK3N|kzKM7:TR?= NHzpe3BUSU6JRWK=
SNU-449 NYD3dXpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRThwMke5N{DPxE1? MV;TRW5ITVJ?
VA-ES-BJ MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfPbFlHUUN3ME24MlM1Pjh4IN88US=> MVPTRW5ITVJ?
HT M2rE[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\rfJJbUUN3ME24MlM3PDlizszN MnnkV2FPT0WU
HOS M2XJUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojZTWM2OD16LkO3OVg6KM7:TR?= NVvhempEW0GQR1XS
KNS-62 NHjXd3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TVRmlEPTB;OD6zO|c3OiEQvF2= M4\nRnNCVkeHUh?=
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A549 NEXTRppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTlwMEm2NVIh|ryP M3i1NXNCVkeHUh?=
CAKI-1 MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XETmlEPTB;OT6xOlYyKM7:TR?= M1LUc3NCVkeHUh?=
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DU-4475 MknuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTlwOU[5N|kh|ryP NFjsOZdUSU6JRWK=
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NCI-H1755 NFu5bZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXQ[o9oUUN3ME2xNE4zPDJ6IN88US=> MojoV2FPT0WU
NCI-H1437 M3i0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljTTWM2OD1zMD61O|I2KM7:TR?= MVTTRW5ITVJ?
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NB5 NHPHclZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLF[2JjUUN3ME2xNE44PTV7IN88US=> MWnTRW5ITVJ?
G-401 M1;1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LpcmlEPTB;MUCuO|YzPiEQvF2= MmD1V2FPT0WU
CAL-72 NImwSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnvXoR6UUN3ME2xNE45ODl2IN88US=> NFvCOlhUSU6JRWK=
SK-MEL-28 M1zyfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFyLkiyNFIh|ryP MX;TRW5ITVJ?
C32 NHr2OFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX0[mVKSzVyPUGwMlg{PDdizszN NF;yfoNUSU6JRWK=
NCI-H1155 NV3rbldbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTkSIhKSzVyPUGwMlg{PzZizszN MoizV2FPT0WU
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LB996-RCC MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi5ZZZFUUN3ME2xNU4xPzJ|IN88US=> NYTRd2FPW0GQR1XS
NCI-H1563 NVf4TVM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjzTWM2OD1zMT6xNFEyKM7:TR?= NWD4RmFMW0GQR1XS
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NCI-H650 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFzLki5OlEh|ryP NEDISFFUSU6JRWK=
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COLO-679 NVfLXXJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nMSWlEPTB;MUGuPVQ3KM7:TR?= M{jOUnNCVkeHUh?=
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D-283MED NX:3O2g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTQdYpQUUN3ME2xNk4xPTZ7IN88US=> M3\WNHNCVkeHUh?=
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BALL-1 M37NUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDrTWM2OD1zMj6yOlYzKM7:TR?= M1;vUXNCVkeHUh?=
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M14 MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPVTWM2OD1zMz6wN|M2KM7:TR?= NWfkfoJwW0GQR1XS
SKG-IIIa MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\lVWxKSzVyPUGzMlA2PTRizszN MV\TRW5ITVJ?
Becker MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn74TWM2OD1zMz6wOVgh|ryP NEjTc|VUSU6JRWK=
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NCI-H2030 NFLFeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTTTWM2OD1zMz6yNFYzKM7:TR?= MlzXV2FPT0WU
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CP50-MEL-B MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOzVpZpUUN3ME2xN{43OjN{IN88US=> M{m1fnNCVkeHUh?=
NCI-H1092 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTF|Lke0O|Uh|ryP MoSzV2FPT0WU
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CAL-27 MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfxNWF1UUN3ME2xOE4xPzJ5IN88US=> MoTRV2FPT0WU
AGS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHpXoZIUUN3ME2xOE4yOzF7IN88US=> NYrMO4xMW0GQR1XS
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BFTC-909 M1;N[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDHTWM2OD1zND61NFU2KM7:TR?= M17nUXNCVkeHUh?=
D-566MG NIq5ZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7zdnZKSzVyPUG0Mlc4ODZizszN MXrTRW5ITVJ?
MZ7-mel MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTYc5BKSzVyPUG1MlExPjdizszN M4\RVHNCVkeHUh?=
TE-5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXkTWM2OD1zNT6yN|M{KM7:TR?= MmjvV2FPT0WU
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DMS-114 M{nYPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT4VZo4UUN3ME2xOU4{OjlzIN88US=> NWXhOVJyW0GQR1XS
ME-180 NHXvNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF3LkS3PFMh|ryP M4[2WXNCVkeHUh?=
MS-1 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXBRYVKSzVyPUG1MlU3OjNizszN M2DOO3NCVkeHUh?=
NUGC-3 NV\NdXloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTF3Lk[yOFUh|ryP MmTHV2FPT0WU
GB-1 NFO3cWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXn0R2VuUUN3ME2xOU43PDN5IN88US=> MXPTRW5ITVJ?
LOXIMVI NET3b3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr5TWM2OD1zNT64PVE6KM7:TR?= MU\TRW5ITVJ?
NCI-H1304 NFPDeGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjNNodKSzVyPUG1Mlg6OjhizszN NHrzXJlUSU6JRWK=
KURAMOCHI MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TUR2lEPTB;MUWuPVcyKM7:TR?= NYHM[nozW0GQR1XS
SW1783 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF4LkC5PVMh|ryP NVvVZZl[W0GQR1XS
EGI-1 NYCxU5M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX6RXZJUUN3ME2xOk42OzZ3IN88US=> M1u3SHNCVkeHUh?=
KGN M{\Yfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYG4VodrUUN3ME2xOk42PTh4IN88US=> NYLnWYRwW0GQR1XS
PANC-03-27 M17aPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\OTWM2OD1zNj63OlYzKM7:TR?= M2fhTXNCVkeHUh?=
RH-1 M4[xWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\CZWlEPTB;MU[uPFI2KM7:TR?= NUHJXJN{W0GQR1XS
HT-1376 M{jxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvzc5U4UUN3ME2xOk45PDR4IN88US=> M3zrb3NCVkeHUh?=
ZR-75-30 MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXFfYJyUUN3ME2xOk46OzZzIN88US=> NHzG[IlUSU6JRWK=
TI-73 NXnQeGJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF4Lkm0NFgh|ryP MVjTRW5ITVJ?
TK10 M2P5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3r[3NKSzVyPUG3MlAxPzlizszN M2W5NXNCVkeHUh?=
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RPMI-8866 Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWqzXZZGUUN3ME2xO{4xPjl7IN88US=> NFr4UI1USU6JRWK=
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NCI-H2291 NVjtUFFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XmN2lEPTB;MUiuOFM1PSEQvF2= NV\QfFI{W0GQR1XS
T47D MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFqxNFRKSzVyPUG4MlQ5QCEQvF2= NW\V[oZyW0GQR1XS
A204 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:wd2lEPTB;MUiuOVQ2OiEQvF2= MUjTRW5ITVJ?
HT-144 NWrBNVZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF6Lke0Nlch|ryP MXjTRW5ITVJ?
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HCC1806 NXHXbIJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP4TWM2OD1zOT6xOVkyKM7:TR?= Ml7sV2FPT0WU
NCI-H596 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTF7Lk[zPVEh|ryP MYXTRW5ITVJ?
K-562 NUX5Z44{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TVSWlEPTB;MUmuPFkzPiEQvF2= M{PJSHNCVkeHUh?=
D-336MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:0TWM2OD1zOT65N|IzKM7:TR?= MojsV2FPT0WU
SK-MEL-2 NHroNpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fi[GlEPTB;MkCuNVU2QSEQvF2= NW\K[pVpW0GQR1XS
HEC-1 NHiyS25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWK4dIZqUUN3ME2yNE41QTd6IN88US=> MoHnV2FPT0WU
EW-13 NYjqc4dzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJyLkW0OFMh|ryP M4DOb3NCVkeHUh?=
Hs-578-T M4PPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnHN|RKSzVyPUKwMlU2QDNizszN NGHUem9USU6JRWK=
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RCC10RGB NYDwe4wxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{S0WmlEPTB;MkCuOlcyQSEQvF2= NYHrTmtiW0GQR1XS
LAN-6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\UTHRTUUN3ME2yNU4xOzl4IN88US=> Ml;PV2FPT0WU
NCI-H1048 NFPRXlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJzLkKyOVgh|ryP NUH2OpRCW0GQR1XS
CW-2 NUfKOIRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJzLkK3NFUh|ryP MV3TRW5ITVJ?
HCC2157 NFviPGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mom2TWM2OD1{MT6zOkDPxE1? NIXZUXRUSU6JRWK=
EW-22 NXTSTY1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi2W4dKSzVyPUKxMlM4PiEQvF2= M2rCb3NCVkeHUh?=
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BE-13 MljhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfvTWM2OD1{MT62NVE{KM7:TR?= MonlV2FPT0WU
KINGS-1 NU[ze5ZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJzLk[zNVYh|ryP M3ThbXNCVkeHUh?=
ETK-1 NVKzVVJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\lUYM2UUN3ME2yNU45OTV{IN88US=> NUDzb5NoW0GQR1XS
NCI-H2452 MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJzLki2OFch|ryP NGrzcnlUSU6JRWK=
HPAF-II NVLkVppET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJzLki5NlMh|ryP NGO5elFUSU6JRWK=
D-542MG NE\xbHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjjTWM2OD1{MT65NFY6KM7:TR?= NFTCTWZUSU6JRWK=
NCI-H630 M{DZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;pVoNKSzVyPUKyMlAzQTZizszN M1P6c3NCVkeHUh?=
TGBC11TKB MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfW[4NKSzVyPUKyMlA1QSEQvF2= NWT5W4xwW0GQR1XS
BCPAP NH71dWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCwcJlLUUN3ME2yNk43OTFizszN M1rCd3NCVkeHUh?=
HLE MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJ{Lk[5O{DPxE1? M1jFXXNCVkeHUh?=
NCI-H727 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P4cmlEPTB;MkKuO|M2KM7:TR?= MkPoV2FPT0WU
RD NILCfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ{Lke1NVgh|ryP MX;TRW5ITVJ?
NCI-H522 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;GTWM2OD1{Mj64OFMyKM7:TR?= MWfTRW5ITVJ?
CGTH-W-1 M{HnS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPzTWM2OD1{Mz6wOlQyKM7:TR?= NVvQNmVzW0GQR1XS
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BB65-RCC MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJ|Lke4OlMh|ryP M3j1enNCVkeHUh?=
HSC-3 NWXU[G5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXGz[GNFUUN3ME2yN{45PTJ5IN88US=> NWjyb5pFW0GQR1XS
SK-MES-1 NHrQS|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;hZnJKSzVyPUK0MlAyPjFizszN MWLTRW5ITVJ?
DB NX\1UWY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX2TWM2OD1{ND6xNFI5KM7:TR?= MnyzV2FPT0WU
HO-1-N-1 M{HObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn2SFZKSzVyPUK0MlMxQTNizszN MUnTRW5ITVJ?
MKN1 NWfKcVZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVztZ3BXUUN3ME2yOE43QCEQvF2= MoS3V2FPT0WU
MN-60 NIrFcIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnERmZKSzVyPUK0Mlg2OTlizszN MUTTRW5ITVJ?
8505C MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjRTXZKSzVyPUK1MlE5PDVizszN NFPKRllUSU6JRWK=
COLO-320-HSR NIn0[5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnSTWM2OD1{NT6yNlA5KM7:TR?= NHzvOY9USU6JRWK=
BB30-HNC Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfHd4dKSzVyPUK1MlI1QDNizszN NXLv[YtGW0GQR1XS
KM12 MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPTc3dTUUN3ME2yOU42QDB5IN88US=> MVjTRW5ITVJ?
NB13 NWXnR2tjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHewb|NKSzVyPUK1MlU5QThizszN MYrTRW5ITVJ?
HCC2998 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJ4LkCyPFMh|ryP MXLTRW5ITVJ?
U-118-MG M4jrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLafGlKSzVyPUK2MlA5ODhizszN NF:2RllUSU6JRWK=
NB10 NXKzVY55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XsUGlEPTB;Mk[uNlM1KM7:TR?= NUW2ToxOW0GQR1XS
SK-LMS-1 NF7FWZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfXTWM2OD1{Nz6wO|A1KM7:TR?= M1;QXnNCVkeHUh?=
SW1573 MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPpOnN6UUN3ME2yO{4yOSEQvF2= M1;hUnNCVkeHUh?=
LB373-MEL-D NFHa[ppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33uTWlEPTB;MkeuNVI6PCEQvF2= NYO0WW9QW0GQR1XS
DK-MG MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrDTWM2OD1{Nz6xPFE4KM7:TR?= MX7TRW5ITVJ?
RMG-I NF3lVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fsUmlEPTB;MkeuNlAzQSEQvF2= NUDWO4JLW0GQR1XS
SW1088 NVHM[HpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOzfolKSzVyPUK3MlUxPDJizszN NGHxVnFUSU6JRWK=
SK-OV-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvLeldbUUN3ME2yO{44PTl|IN88US=> MojwV2FPT0WU
KP-N-YN NUO1eXlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HtcGlEPTB;MkeuPFA1OyEQvF2= M2C2enNCVkeHUh?=
RPMI-7951 NGjNbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjDe4FKSzVyPUK4MlI1PTZizszN M2fJTnNCVkeHUh?=
CaR-1 M1\oSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLCbGZKSzVyPUK4MlU2QDJizszN Ml[3V2FPT0WU
MKN7 MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DtOWlEPTB;MkiuOVk3PCEQvF2= MYfTRW5ITVJ?
CHP-212 NF74TppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;vTWM2OD1{OD63OFAyKM7:TR?= M3HqUXNCVkeHUh?=
KYSE-450 NGWyT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPSbHpnUUN3ME2yPE45ODlzIN88US=> M2XkSXNCVkeHUh?=
RXF393 NGrLfYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTJ7LkK5NFYh|ryP M37YenNCVkeHUh?=
P30-OHK M4\JSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPyZXgzUUN3ME2yPU4{ODR6IN88US=> MXHTRW5ITVJ?
Ca9-22 NV3renVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HSZWlEPTB;MkmuOFI6QSEQvF2= M4rkWnNCVkeHUh?=
RT-112 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJ7LkS2NVEh|ryP NFfTSYpUSU6JRWK=
ES1 Mo\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDXSWdKSzVyPUK5Mlg2PDRizszN Mo\0V2FPT0WU
HCE-4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ7Lki3PFYh|ryP NUSwUpU5W0GQR1XS
AM-38 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7xcYtKSzVyPUOwMlA3ODZizszN Ml3UV2FPT0WU
AsPC-1 NIfSbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXPNZdKSzVyPUOwMlgxPTNizszN NGDuRmRUSU6JRWK=
TE-9 NVTrPWdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;DWJduUUN3ME2zNE45PzN5IN88US=> M{fkcnNCVkeHUh?=
HuP-T4 NIDiO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTNyLkm2N|gh|ryP MlmzV2FPT0WU
LB2518-MEL NGPtbVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFy5T49KSzVyPUOxMlA4PDRizszN NUS3XW5bW0GQR1XS
NCI-H1703 NYf1OlJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT2TWM2OD1|MT6wPVA2KM7:TR?= NEjybYxUSU6JRWK=
NCI-H2228 NHrnPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTNzLkS2OVEh|ryP NHHncIxUSU6JRWK=
SCC-4 NHPqRVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\oTYdKSzVyPUOxMlkyQDFizszN MV\TRW5ITVJ?
KNS-81-FD M3jFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLmTWM2OD1|Mj6wNVI5KM7:TR?= M1rN[nNCVkeHUh?=
NTERA-S-cl-D1 NXjTVmJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXVfJVKSzVyPUOyMlA4OzlizszN MonaV2FPT0WU
Daoy NFj6U2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXrSlZKSzVyPUOyMlA5OzhizszN MV;TRW5ITVJ?
ES4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\zSWlEPTB;M{KuN|kzOiEQvF2= NYTQT3lQW0GQR1XS
MHH-ES-1 NHPXNGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnznTWM2OD1|Mj60PFczKM7:TR?= NYrsOWZ{W0GQR1XS
C-33-A NGPWWFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTN{Lke3Nlgh|ryP NITwZVdUSU6JRWK=
BHY NEnHNnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7YWVZnUUN3ME2zNk46PDl3IN88US=> Mn3hV2FPT0WU
Detroit562 NXGy[|dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TiN2lEPTB;M{OuOlY2PyEQvF2= MVzTRW5ITVJ?
EW-1 NHrsb4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTN|LkmzNlIh|ryP M3T2VHNCVkeHUh?=
NCI-H1395 M3vOXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TkUGlEPTB;M{SuNFc6QSEQvF2= NWjzRYg5W0GQR1XS
KM-H2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fYcGlEPTB;M{[uOFc1OyEQvF2= M4G5e3NCVkeHUh?=
NCI-H520 NYrVVnBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnz[JZKSzVyPUO2Mlc2PDFizszN NV;pdmo3W0GQR1XS
D-392MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmewTWM2OD1|Nz6zN|Q1KM7:TR?= Mk\1V2FPT0WU
NOMO-1 Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nR[WlEPTB;M{euPFA5QSEQvF2= MVPTRW5ITVJ?
TE-6 M1fSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjsXFFKSzVyPUO4MlEzPCEQvF2= NIq4Z|VUSU6JRWK=
HT-3 NID5N41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17BZ2lEPTB;M{iuOFQ{PiEQvF2= NH7JO2hUSU6JRWK=
RPMI-8226 NWLON3hmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTN6Lkm1NVkh|ryP MXzTRW5ITVJ?
U251 M2\Ncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN7LkCxNlQh|ryP NXfJPZMzW0GQR1XS
GCT M1zP[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LxU2lEPTB;M{muNVg2OiEQvF2= Mn:zV2FPT0WU
A431 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT1TWM2OD1|OT6xPFk1KM7:TR?= MX;TRW5ITVJ?
TE-12 NYf5O3JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv3UG91UUN3ME2zPU4zPDR6IN88US=> Ml;mV2FPT0WU
HMV-II NF63c45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTN7LkWwOFch|ryP MY\TRW5ITVJ?
IST-MES1 NHnweFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLnV4VTUUN3ME20NE4yPTB{IN88US=> NIDvZVlUSU6JRWK=
SW13 NYXNeGlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj0[2NYUUN3ME20NE42OTlizszN Mmr0V2FPT0WU
SF295 NVnrWmF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH5eY5KSzVyPUSwMlgxPjZizszN MkDyV2FPT0WU
MDA-MB-157 NV7XUHF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXpTYo2UUN3ME20NE46PDZ{IN88US=> Mo\yV2FPT0WU
TE-1 NEHSRZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rmfGlEPTB;NEGuPFcyPCEQvF2= NUf4OFAzW0GQR1XS
HuCCT1 NH3j[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfUWWx4UUN3ME20Nk42Ojh7IN88US=> MoroV2FPT0WU
KYSE-510 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3q[YxpUUN3ME20N{4yPzV2IN88US=> MoDWV2FPT0WU
NCI-H358 NWHYbFJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13m[2lEPTB;NESuNFMxPCEQvF2= M{TyWXNCVkeHUh?=
SW900 NIDmXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTSflFKSzVyPUS0MlA4PThizszN MkfFV2FPT0WU
CAS-1 NGn0eY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jHXmlEPTB;NESuNFk6OSEQvF2= MVzTRW5ITVJ?
TE-8 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTR2LkW2OVgh|ryP MnvEV2FPT0WU
P12-ICHIKAWA NF;IeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S1WWlEPTB;NESuOlEyOiEQvF2= MoWxV2FPT0WU
YKG-1 NIPaWmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonqTWM2OD12ND63PFEh|ryP NHPwfmtUSU6JRWK=
SNU-C2B Mn;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTR2Lke5NFMh|ryP NHfESVNUSU6JRWK=
LCLC-103H MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDaTGttUUN3ME20OE45PzB|IN88US=> NUnmRohoW0GQR1XS
U-87-MG MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTR3LkGwNlIh|ryP MXzTRW5ITVJ?
HAL-01 NEe0XJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTWTWM2OD12NT6xN|c6KM7:TR?= NV;UZZNUW0GQR1XS
OVCAR-8 Mm\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXKXXVHUUN3ME20OU4{PTZ2IN88US=> NG\ESotUSU6JRWK=
KYSE-150 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j6O2lEPTB;NEeuNVA2OiEQvF2= MULTRW5ITVJ?
OE33 MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHnSGpmUUN3ME20O{4yPDJ7IN88US=> MkDLV2FPT0WU
CAL-62 NGDTNVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXzfFVqUUN3ME20O{41ODZ6IN88US=> NEn2bpJUSU6JRWK=
TCCSUP M2jCO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nHO2lEPTB;NEeuOlI3PCEQvF2= NGLrTVdUSU6JRWK=
H4 NX;wZno1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTR5Lk[2NlEh|ryP MY\TRW5ITVJ?
CP66-MEL NUDCXGlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTR6LkC3NFQh|ryP NU\uO4JmW0GQR1XS
SNB75 NIPkRZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX4OW1KUUN3ME20PE4yQDd2IN88US=> M{\IXXNCVkeHUh?=
Mo-T MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTpR486UUN3ME20PE4zPzlizszN NV7Pe3RYW0GQR1XS
BT-549 MkjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnVVG9KSzVyPUS4MlM4OjlizszN NFTndIxUSU6JRWK=
IGR-1 MoTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[xTWM2OD12OD62OlQ2KM7:TR?= NFvwcXFUSU6JRWK=
NCI-H1299 M{fKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DxN2lEPTB;NEiuO|I1QCEQvF2= MXLTRW5ITVJ?
ALL-PO M3:0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTR7LkmyOlgh|ryP NF:2O5pUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]
臨床試験
特集

プロトコル (参考用のみ)

細胞アッセイ: [2]

細胞株 SW620, LoVo, V3-YAC and V3 cells
濃度 0.5 μM or 1 μM
反応時間 17 hours
実験の流れ The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.

動物実験: [2]

動物モデル Female rude mice bearing SW620 xenografts
製剤 Sterile 0.9% sodium chloride solution
投薬量 10 mg/kg
投与方法 Intraperitoneally administrated

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download NU7441 (KU-57788) SDF
分子量 413.49
化学式

C25H19NO3S

CAS No. 503468-95-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 3 mg/mL (7.25 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

カスタマーフィードバック (4)


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Rating
Source Nucleic Acids Res, 2013, 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck
Method EU Immunofluorescence
Cell Lines A2780 ovarian cancer cells
Concentrations 1 uM
Incubation Time 1 h
Results It performed similar experiments using specific inhibitors of DNA-PK. Treatment with Nu7026 or Nu7441 before cisplatin significantly prevented inhibition of rRNA synthesis.

Click to enlarge
Rating
Source Nucleic Acids Res, 2013, 41, 10157-69. NU7441 (KU-57788) purchased from Selleck
Method Confocal immunostaining
Cell Lines 293T
Concentrations
Incubation Time 30min ,60min
Results the number of IRIFs was reduced significantly in p18CycE-expressing HEK 293T cells compared with parental cells. Pharmacological inhibition of ATM with KU55933 Revealed that S25-53BP1 phosphorylation was ATM-dependent in these cells as IRIFs of S25-53BP1 were abolished in both parental, as well as p18CycE-expressing cells.

Click to enlarge
Rating
Source Toxicol Sci, 2014, 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck
Method Western blot
Cell Lines H460 cells
Concentrations 1, 3, 10 uM
Incubation Time 1 h
Results It tested 3 concentrations of 2 DNAPK inhibitors (NU7026 and NU7441) for their off-target effects on ATM and ATR signaling in camptothecin-exposed cells. We found that only the highest dose of 60 uM NU7026 clearly diminished ATR activity as evidenced by a lower CHK1 phosphorylation. All doses of both inhibitors eliminated activating autophosphorylation of DNAPK at Ser2056.

Click to enlarge
Rating
Source Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck
Method
Cell Lines A549 cells
Concentrations 0-10 μM
Incubation Time 3 h
Results NU-7441 treatment resulted in a reduction of AKT phosphorylation.

文献中の引用 (14)

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    CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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