NU7441 (KU-57788) 化学構造
分子量: 413.49

高品質保証

カスタマーフィードバック(4)

MSDS

製品説明

  • Compare DNA-PK Inhibitors
    DNA-PK製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 NU7441 (KU-57788)は1種の有効的で、セレクティブDNA-PK抑制剤です。NU7441 (KU-57788)は無細胞試験でIC50値が14 nMで、PI3Kも抑制します。このIC50値は5 μMです。
ターゲット DNA-PK
IC50 14 nM [1]
In vitro試験 NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. [2] NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. [3] NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. [4] NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. [5] NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H1770 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O3OmlEPTB;MD6wNlE1OyEQvF2= MmLBV2FPT0WU
A172 NITjSXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;Ib2lEPTB;MD6xOVMyPiEQvF2= MUHTRW5ITVJ?
NCI-H526 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInJflRKSzVyPUCuNlg1ODdizszN MXXTRW5ITVJ?
HDLM-2 M{C4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwM{KzOFUh|ryP MVXTRW5ITVJ?
HuO-3N1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13aS2lEPTB;MD60OlY{PiEQvF2= NX;HWGlSW0GQR1XS
NCI-SNU-1 MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXlTnJrUUN3ME2wMlYxQTl2IN88US=> MmnlV2FPT0WU
SK-N-AS MmXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDZ[3FOUUN3ME2wMlYzOjF4IN88US=> M362SnNCVkeHUh?=
LoVo NV3MTXk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K2UGlEPTB;MD64Olc1QSEQvF2= M321cXNCVkeHUh?=
LAMA-84 Mnn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwOUi4N|Mh|ryP M4HifHNCVkeHUh?=
CTB-1 NFK4Z|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfJNWxKSzVyPUGuNVE2PDZizszN NYD3U5B4W0GQR1XS
KP-N-YS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFz6Z|BKSzVyPUGuNVQzOzFizszN MoTyV2FPT0WU
HH NVHheG1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC1bplKSzVyPUGuNVgxQTNizszN M13WeXNCVkeHUh?=
CHL-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL6[21QUUN3ME2xMlIyOzZ6IN88US=> MXzTRW5ITVJ?
NB7 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS3TWM2OD1zLkK0O|Q2KM7:TR?= Mn\vV2FPT0WU
HL-60 M4jjXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\uc2lEPTB;MT6zPFE6KM7:TR?= MX\TRW5ITVJ?
639-V NV[5cJFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTsOZJYUUN3ME2xMlQ1OTJ6IN88US=> NUHMN5pZW0GQR1XS
NCI-H1793 NX[2bHp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDEfGRqUUN3ME2xMlQ2QDRizszN M4PBeHNCVkeHUh?=
NEC8 NGG0OFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnCTWM2OD1zLkW1N|Uh|ryP Ml\yV2FPT0WU
PA-1 MnS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofxTWM2OD1zLkW4Nlk1KM7:TR?= M2LxTXNCVkeHUh?=
D-423MG Mn7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFwNkmzOlEh|ryP NXexfXVOW0GQR1XS
NCI-H292 NXvIXZhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTFwN{SwNVMh|ryP MVfTRW5ITVJ?
SK-MEL-1 M3jG[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPBdJNKSzVyPUGuO|k1PzlizszN MoHVV2FPT0WU
LB2241-RCC M2WyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrkXnFwUUN3ME2yMlE1OTR4IN88US=> NYTQWlVvW0GQR1XS
SK-MEL-3 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHyRolvUUN3ME2yMlE3PDlizszN MlPPV2FPT0WU
MHH-PREB-1 NV7OWGhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfBTWM2OD1{LkG2OlA6KM7:TR?= MUnTRW5ITVJ?
BFTC-905 NFXUUnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\kXWR[UUN3ME2yMlE3Pjh5IN88US=> NEnOfWlUSU6JRWK=
Ramos-2G6-4C10 NV3YRph1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJwMUm5NFkh|ryP Mkf5V2FPT0WU
G-361 MnjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrtXHZKSzVyPUKuNlE3QCEQvF2= NGHVOGpUSU6JRWK=
MOLT-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVuydmx4UUN3ME2yMlIyQDh6IN88US=> NXzFTFFJW0GQR1XS
DEL MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJwM{W1OlQh|ryP M4m4S3NCVkeHUh?=
MV-4-11 NYP0eIJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\xbFcyUUN3ME2yMlM4OzlizszN MlrFV2FPT0WU
SK-NEP-1 NFjqPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJwM{i3PFMh|ryP MXzTRW5ITVJ?
RS4-11 NF3YdFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPse|VKSzVyPUKuOVYxOjNizszN MkPTV2FPT0WU
HuH-7 NYW2W3pZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vWTmlEPTB;Mj61OlcxOiEQvF2= MnT5V2FPT0WU
A101D MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nUR2lEPTB;Mj62NVM{QCEQvF2= M{[wUXNCVkeHUh?=
KG-1 NGXSUZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjXTGR5UUN3ME2yMlY4QTJ2IN88US=> NFy3[3JUSU6JRWK=
KALS-1 NGLzcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH1eIdWUUN3ME2yMlY6PjN|IN88US=> NV:zRnR7W0GQR1XS
VMRC-RCZ MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\CTWM2OD1{Lke3N|I5KM7:TR?= M1vnfXNCVkeHUh?=
SK-UT-1 MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrpenpKSzVyPUOuNVU{OSEQvF2= NInSe4JUSU6JRWK=
SW962 NUjJNFk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\kTWM2OD1|LkKwN|UzKM7:TR?= M3nUfnNCVkeHUh?=
DBTRG-05MG NVXWZYxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULMOHRxUUN3ME2zMlI5ODh3IN88US=> NFrM[JNUSU6JRWK=
PANC-08-13 NIDHV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjHcVBKSzVyPUOuOFEzPzhizszN NH\BbnVUSU6JRWK=
QIMR-WIL MkTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzCWJVKSzVyPUOuOFE{PDFizszN MUDTRW5ITVJ?
SK-MEL-30 M{TUXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPTSllRUUN3ME2zMlQzPTl6IN88US=> NX3pVHZPW0GQR1XS
697 M3;6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTNwNES5PVMh|ryP NYXDem8yW0GQR1XS
NY NXLxfndpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q3TGlEPTB;Mz60OVAzOiEQvF2= NXPlfHFnW0GQR1XS
ES7 NVH1doQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTNwNE[3Nlkh|ryP MmfaV2FPT0WU
JVM-3 NV;EW2p5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPWdWZ5UUN3ME2zMlQ5ODd5IN88US=> M3jXZnNCVkeHUh?=
U031 M3\wSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n0cGlEPTB;Mz61PVM3QCEQvF2= NIXNOmVUSU6JRWK=
BHT-101 NIDNU5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTNwNUm5PFUh|ryP M2LRfnNCVkeHUh?=
8305C NWPrVZlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7XXlJKSzVyPUOuOlE4OzZizszN MoLTV2FPT0WU
MG-63 NFLocZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTNwNkK2O|Yh|ryP NGTyXppUSU6JRWK=
NOS-1 NHHsbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2SzfWlEPTB;Mz62OVMyOiEQvF2= NV\yR2RjW0GQR1XS
YH-13 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD2N5dZUUN3ME2zMlg4OTh7IN88US=> MlW3V2FPT0WU
LXF-289 M2rCNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrBXJVKSzVyPUOuPVExPDFizszN NG\OflRUSU6JRWK=
GOTO Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnYUHVKSzVyPUOuPVE1QSEQvF2= MYnTRW5ITVJ?
EKVX MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXvTWM2OD12LkKyOVI1KM7:TR?= MVHTRW5ITVJ?
CAL-51 MnfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTRwMkS4OVQh|ryP NW\rPVVXW0GQR1XS
AN3-CA Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\2PYpKSzVyPUSuNlU5OTNizszN NXfSZ|QzW0GQR1XS
IA-LM NX65XJBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHnSFRxUUN3ME20MlI4QTN3IN88US=> MkHaV2FPT0WU
KU-19-19 NUjueGJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTRwM{K5NlEh|ryP M3rkW3NCVkeHUh?=
A704 NIPvTppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TUemlEPTB;ND60NFg5QCEQvF2= MnzBV2FPT0WU
RH-18 NYTzdHVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13qNmlEPTB;ND60OFk2OyEQvF2= Mn\IV2FPT0WU
IST-MEL1 MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTRwNUiyOlMh|ryP NVTMZ4dNW0GQR1XS
LU-134-A NXTqcotxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn3N4NKSzVyPUSuOVk3QDVizszN NWDOS45YW0GQR1XS
SF126 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTUTWdKSzVyPUSuOlA4OTVizszN MkfRV2FPT0WU
EFO-27 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTRwNk[1NlUh|ryP NVf2OFE3W0GQR1XS
SN12C MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFriellKSzVyPUSuO|E5QThizszN MVLTRW5ITVJ?
L-363 NF7NO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTRwN{exNVYh|ryP MoPXV2FPT0WU
MEL-HO M{SzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7kVopKUUN3ME20Mlc4QTh7IN88US=> Ml;PV2FPT0WU
TYK-nu NXjReGd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIr2[oxKSzVyPUSuPFAyOjhizszN MmfIV2FPT0WU
MDA-MB-415 NVLIdo5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTVwMECzNVQh|ryP M4\z[nNCVkeHUh?=
HCC70 NGnwNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTVwMEO5N|kh|ryP MmruV2FPT0WU
IGROV-1 NXLZXm5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvyWXVxUUN3ME21MlI2Ojl{IN88US=> MV7TRW5ITVJ?
NCI-H1355 NV7wSGNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDZZVdKSzVyPUWuNlk3KM7:TR?= MV\TRW5ITVJ?
23132-87 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTVwM{KwNlQh|ryP Mn\ZV2FPT0WU
NB69 NInRZ3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfaTWM2OD13LkOyOFIh|ryP MXPTRW5ITVJ?
HSC-2 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rFRWlEPTB;NT60NVc4OyEQvF2= NWLWZYczW0GQR1XS
KYSE-410 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnZN3NrUUN3ME21MlQ4PjN4IN88US=> NWizV4NvW0GQR1XS
GCIY NFnvWXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrLOpdHUUN3ME21MlUyOzd6IN88US=> M4rr[XNCVkeHUh?=
A427 M4rmc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHCS5ZKSzVyPUWuOVM3PjFizszN M{PoVHNCVkeHUh?=
ChaGo-K-1 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnpPWFuUUN3ME21MlU3PTl7IN88US=> MoXWV2FPT0WU
PFSK-1 NU\OS5FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPoWWpSUUN3ME21MlYzOTl2IN88US=> NF3DeHBUSU6JRWK=
MLMA NUO3VJY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDJTWM2OD13LkizOlA3KM7:TR?= M1;0[XNCVkeHUh?=
RVH-421 NXjzPZE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrrTWM2OD14LkC3N|M5KM7:TR?= NGjGTFBUSU6JRWK=
LB1047-RCC NWDDRm42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTZwMUe1NlIh|ryP NGT6T5lUSU6JRWK=
MHH-NB-11 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nSdWlEPTB;Nj6zNlczOSEQvF2= MWPTRW5ITVJ?
J-RT3-T3-5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrSTWM2OD14Lk[zNlkyKM7:TR?= MWHTRW5ITVJ?
UM-UC-3 MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLteXRKSzVyPU[uOlQ{OzRizszN M3TKb3NCVkeHUh?=
IST-SL1 MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPiNo9KSzVyPU[uOlk{PjlizszN NG\0cFVUSU6JRWK=
NB14 NIntbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LQTGlEPTB;Nj63PVc3OSEQvF2= NF;sT3pUSU6JRWK=
NBsusSR MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfMXHNmUUN3ME22MlgzPTB{IN88US=> NFvCWlRUSU6JRWK=
D-263MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPSVGhKSzVyPU[uPVExPjhizszN NVGzdpRsW0GQR1XS
NCI-H2347 NUTxd4x6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3CW2F3UUN3ME22Mlk{OjF|IN88US=> MUjTRW5ITVJ?
ES8 NVzvRXV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTZwOUe1PFgh|ryP M2DNW3NCVkeHUh?=
786-0 M3v2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTdwMEm3PFYh|ryP M{PQOnNCVkeHUh?=
EPLC-272H Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33DPGlEPTB;Nz6xOlI1PiEQvF2= MUnTRW5ITVJ?
CAPAN-1 M1PIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH3TWM2OD15LkK0N|U6KM7:TR?= M2nDXnNCVkeHUh?=
NCI-H82 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHr[WtKSzVyPUeuNlY3PTlizszN MVXTRW5ITVJ?
G-402 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTdwM{CwOVEh|ryP M2rDNXNCVkeHUh?=
SW982 M3LFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnxTWM2OD15LkOwNlA{KM7:TR?= NVjGOWhFW0GQR1XS
OVCAR-4 NWfQdItET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn3clh4UUN3ME23MlMyOzJ6IN88US=> MWLTRW5ITVJ?
KARPAS-299 NGrDUYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKyV4NKSzVyPUeuN|I3OjJizszN M1P5dXNCVkeHUh?=
MIA-PaCa-2 MkWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjMeHRKSzVyPUeuN|Y5OjNizszN MV;TRW5ITVJ?
AU565 NX:4S3dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDxTWM2OD15LkW5PFM{KM7:TR?= NGnWbVZUSU6JRWK=
GAMG NXyyfIYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomzTWM2OD15Lk[0NVMyKM7:TR?= NXzpZoNJW0GQR1XS
HuO9 M17JcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHaZ5ZQUUN3ME23MlcyPzR|IN88US=> NU\XXmlDW0GQR1XS
ACN MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPTZWxKSzVyPUeuO|Q{OyEQvF2= NETM[HRUSU6JRWK=
RO82-W-1 NHzQ[JVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTdwN{S1N|Mh|ryP M4OzNHNCVkeHUh?=
NKM-1 M{jYZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHaN4dKSzVyPUeuO|Q6PTVizszN NV2wNnVEW0GQR1XS
CAL-12T MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTdwOUSzOVIh|ryP MkP6V2FPT0WU
FADU NVzh[mFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Djc2lEPTB;OD6wN|Y2PCEQvF2= MX7TRW5ITVJ?
NCI-H28 NVXQN5R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHGxb2xKSzVyPUiuNVY6PjJizszN M4TLW3NCVkeHUh?=
LCLC-97TM1 NEHVUGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjWb4NKSzVyPUiuNlEyOjJizszN NYXYOVNOW0GQR1XS
CHP-134 Ml\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH1TWM2OD16LkK0NVg2KM7:TR?= M4fPS3NCVkeHUh?=
HT-1080 Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7iVGFIUUN3ME24MlI2ODl|IN88US=> M3OyW3NCVkeHUh?=
PC-3 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRThwMkezPVIh|ryP NFT5VIpUSU6JRWK=
SNU-449 NEfibHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHVTWM2OD16LkK3PVMh|ryP MmjlV2FPT0WU
VA-ES-BJ NUXG[WQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRThwM{S2PFYh|ryP MWTTRW5ITVJ?
HT NFjvSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DPW2lEPTB;OD6zOlQ6KM7:TR?= MXLTRW5ITVJ?
HOS MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRThwM{e1PFkh|ryP NXXFVFZ2W0GQR1XS
KNS-62 NVzhblIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRThwM{e3OlIh|ryP NEPyfWRUSU6JRWK=
OAW-42 Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{joSWlEPTB;OD65OVk3PCEQvF2= MmHQV2FPT0WU
A549 MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWGxRW5XUUN3ME25MlA6PjF{IN88US=> NETHdXBUSU6JRWK=
CAKI-1 NIjm[41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DSO2lEPTB;OT6xOlYyKM7:TR?= M3T6THNCVkeHUh?=
HCC1937 M3TrZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGi2RWpKSzVyPUmuOlk5PjVizszN M1fYdnNCVkeHUh?=
GI-ME-N NFTYeWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXjOmg5UUN3ME25MlcxOTN5IN88US=> M{TFOXNCVkeHUh?=
DU-4475 NVqzcmxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TEbWlEPTB;OT65Olk{QSEQvF2= NYXVN4drW0GQR1XS
EM-2 NFf5T3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLjTWM2OD1zMD6yOFI3KM7:TR?= MX\TRW5ITVJ?
NCI-H1755 M1\LNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfRbIhKSzVyPUGwMlI1OjhizszN NF3nXIFUSU6JRWK=
NCI-H1437 NFjiVG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjuVXBVUUN3ME2xNE42PzJ3IN88US=> NYizNIM6W0GQR1XS
VM-CUB-1 M1LGdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTFyLk[xOlQh|ryP NVrzOZVjW0GQR1XS
A2058 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnqTWM2OD1zMD62OFA1KM7:TR?= M3HEXXNCVkeHUh?=
BPH-1 NHTHTVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jIdGlEPTB;MUCuO|E1PSEQvF2= M4S2e3NCVkeHUh?=
NB5 MlP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fDUWlEPTB;MUCuO|U2QSEQvF2= Mn3oV2FPT0WU
G-401 MmjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDMd|ZSUUN3ME2xNE44PjJ4IN88US=> MlHGV2FPT0WU
CAL-72 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\yV3RCUUN3ME2xNE45ODl2IN88US=> NV3pdoVMW0GQR1XS
SK-MEL-28 NIW5VHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDNTWM2OD1zMD64NlAzKM7:TR?= MULTRW5ITVJ?
C32 NGnXU|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfsTWM2OD1zMD64N|Q4KM7:TR?= NVLWVo92W0GQR1XS
NCI-H1155 MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFyLkizO|Yh|ryP Mn7CV2FPT0WU
BB49-HNC MlXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfmfVlKSzVyPUGwMlg2QDZizszN NXHGcHVtW0GQR1XS
GMS-10 NVzwc2Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zMR2lEPTB;MUCuPFk4OSEQvF2= NULoR|B6W0GQR1XS
K5 MoXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LVPWlEPTB;MUCuPVA4OSEQvF2= Mne2V2FPT0WU
OS-RC-2 M1j6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIiwN4lKSzVyPUGxMlA2PTlizszN MX\TRW5ITVJ?
HTC-C3 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLSSHhnUUN3ME2xNU4xPzF2IN88US=> NVnvXVhNW0GQR1XS
LB996-RCC MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnuyTWM2OD1zMT6wO|I{KM7:TR?= NVn4cXVzW0GQR1XS
NCI-H1563 NFn5eolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2judmlEPTB;MUGuNVAyOSEQvF2= NEK3OJVUSU6JRWK=
CAL-54 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfKd2RKSzVyPUGxMlQ5OTFizszN NE\VNXBUSU6JRWK=
WM-115 NVnGc29uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXIOGdqUUN3ME2xNU43QDJ2IN88US=> MmLhV2FPT0WU
COLO-684 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rmNGlEPTB;MUGuO|I3PyEQvF2= MmexV2FPT0WU
HOP-62 NGDxW|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL0V5FKSzVyPUGxMlc2ODhizszN MnrvV2FPT0WU
NCI-H650 NHqwWZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXlUXVKSzVyPUGxMlg6PjFizszN MY\TRW5ITVJ?
TE-11 NIL3S4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\PbZh1UUN3ME2xNU46OzF3IN88US=> MkXRV2FPT0WU
COLO-679 M3Lp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz3VY5KSzVyPUGxMlk1PiEQvF2= NIX2TIxUSU6JRWK=
FTC-133 Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGG1bJNKSzVyPUGyMlAxPzZizszN MWnTRW5ITVJ?
D-283MED NEfIOoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK5TWM2OD1zMj6wOVY6KM7:TR?= MUPTRW5ITVJ?
SK-PN-DW NXX5WYdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorTTWM2OD1zMj6xPVAzKM7:TR?= NHjmOnBUSU6JRWK=
BALL-1 NWTPV|FmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrCR2ZKSzVyPUGyMlI3PjJizszN M4TEXXNCVkeHUh?=
GT3TKB M3nZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfjSJdKSzVyPUGyMlMxPzRizszN MoP2V2FPT0WU
HOP-92 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLxTWM2OD1zMj61NlM{KM7:TR?= MmP1V2FPT0WU
M14 MnG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPpTWM2OD1zMz6wN|M2KM7:TR?= MUXTRW5ITVJ?
SKG-IIIa M4n4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7RTHJKSzVyPUGzMlA2PTRizszN MmS0V2FPT0WU
Becker NVX1U4w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF|LkC1PEDPxE1? NYHZc5RrW0GQR1XS
ES5 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L4eWlEPTB;MUOuNVM2PiEQvF2= NWWyXHNKW0GQR1XS
NCI-H2030 M3v0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;xZWlEPTB;MUOuNlA3OiEQvF2= Mn\uV2FPT0WU
SNU-423 NGXBcXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjLO|BKSzVyPUGzMlM5OSEQvF2= MoHaV2FPT0WU
CP50-MEL-B NUnUbGx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTF|Lk[yN|Ih|ryP MkXvV2FPT0WU
NCI-H1092 NUW0R|NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfpdZhDUUN3ME2xN{44PDd3IN88US=> Mo\YV2FPT0WU
8-MG-BA M4Hkbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT3TY1KSzVyPUGzMlc2OTNizszN NFrmPZBUSU6JRWK=
CAL-27 M37Lb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF2LkC3Nlch|ryP NIrGNVRUSU6JRWK=
AGS Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLpdm1KSzVyPUG0MlE{OTlizszN MUDTRW5ITVJ?
MZ2-MEL MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjpcYF3UUN3ME2xOE4yPDh6IN88US=> M2jGV3NCVkeHUh?=
BFTC-909 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoW3TWM2OD1zND61NFU2KM7:TR?= NXfDUlZCW0GQR1XS
D-566MG NGr0OpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF2Lke3NFYh|ryP M4n3SXNCVkeHUh?=
MZ7-mel NW\JclNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTF3LkGwOlch|ryP NHvwbYJUSU6JRWK=
TE-5 NV31dZVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjuV|NKSzVyPUG1MlI{OzNizszN MWnTRW5ITVJ?
647-V MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTF3LkK3NFUh|ryP NEL3c45USU6JRWK=
DMS-114 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK3VXRKSzVyPUG1MlMzQTFizszN NX[xWo94W0GQR1XS
ME-180 NWHtXZFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXnXZNKSzVyPUG1MlQ4QDNizszN M1;3NHNCVkeHUh?=
MS-1 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWCw[YQ4UUN3ME2xOU42PjJ|IN88US=> M2fSXXNCVkeHUh?=
NUGC-3 MkSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPRSZFKSzVyPUG1MlYzPDVizszN NIL0ZYxUSU6JRWK=
GB-1 NWD5T24yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITvcGVKSzVyPUG1MlY1OzdizszN NUC3OZp1W0GQR1XS
LOXIMVI M{TXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF3Lki5NVkh|ryP NXXKUXFlW0GQR1XS
NCI-H1304 NXXPWppzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXtTWM2OD1zNT64PVI5KM7:TR?= MU\TRW5ITVJ?
KURAMOCHI M4XobGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITLT3RKSzVyPUG1Mlk4OSEQvF2= MnXyV2FPT0WU
SW1783 M3rpNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF4LkC5PVMh|ryP NFO5SnRUSU6JRWK=
EGI-1 M4LhR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjoTJJpUUN3ME2xOk42OzZ3IN88US=> M{fWTXNCVkeHUh?=
KGN MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP5e4ZKSzVyPUG2MlU2QDZizszN NXz6OGZKW0GQR1XS
PANC-03-27 MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL4NIhqUUN3ME2xOk44PjZ{IN88US=> NGjBe3dUSU6JRWK=
RH-1 NFqxOW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXpOHZKSzVyPUG2MlgzPSEQvF2= NFXWcVBUSU6JRWK=
HT-1376 NIDFUHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPNXmFYUUN3ME2xOk45PDR4IN88US=> NYr3N|dYW0GQR1XS
ZR-75-30 M3\5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv4TWM2OD1zNj65N|YyKM7:TR?= M1T0N3NCVkeHUh?=
TI-73 NFnv[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvTdIZIUUN3ME2xOk46PDB6IN88US=> NGri[YpUSU6JRWK=
TK10 Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\yUWlEPTB;MUeuNFA4QSEQvF2= MVrTRW5ITVJ?
SW684 NXr0TYxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTF5LkCxOVQh|ryP NX\tT5ZbW0GQR1XS
RPMI-8866 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzsfWZEUUN3ME2xO{4xPjl7IN88US=> NGLrR2RUSU6JRWK=
LNCaP-Clone-FGC MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF5LkWyNFEh|ryP MYfTRW5ITVJ?
NCI-H2291 NWj4PWd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NECzTlNKSzVyPUG4MlQ{PDVizszN NHWycXZUSU6JRWK=
T47D M1rpbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTF6LkS4PEDPxE1? MXjTRW5ITVJ?
A204 NFPRclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzaO4tiUUN3ME2xPE42PDV{IN88US=> NE\mcIRUSU6JRWK=
HT-144 NH[0eXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTF6Lke0Nlch|ryP MV;TRW5ITVJ?
MDA-MB-361 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjYdnlrUUN3ME2xPU4xPzF2IN88US=> M4DxfHNCVkeHUh?=
HCC1806 M{Ptd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm3TWM2OD1zOT6xOVkyKM7:TR?= MYLTRW5ITVJ?
NCI-H596 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrwdo9KSzVyPUG5MlY{QTFizszN M{n4fHNCVkeHUh?=
K-562 MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX61WZp7UUN3ME2xPU45QTJ4IN88US=> NWLPOop4W0GQR1XS
D-336MG Ml;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrYWmRKSzVyPUG5Mlk{OjJizszN MV\TRW5ITVJ?
SK-MEL-2 NH72OphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PyNmlEPTB;MkCuNVU2QSEQvF2= NFr1SJdUSU6JRWK=
HEC-1 MkjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTNTWM2OD1{MD60PVc5KM7:TR?= NUTENZdbW0GQR1XS
EW-13 MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGftdGlKSzVyPUKwMlU1PDNizszN MWDTRW5ITVJ?
Hs-578-T NEfzWmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXaS2VKSzVyPUKwMlU2QDNizszN MWDTRW5ITVJ?
SJSA-1 NXHrNZQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK5e29QUUN3ME2yNE42Pjh6IN88US=> NWfDT21qW0GQR1XS
RCC10RGB M3z6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\1TWM2OD1{MD62O|E6KM7:TR?= M4TZOnNCVkeHUh?=
LAN-6 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P4WWlEPTB;MkGuNFM6PiEQvF2= MnHhV2FPT0WU
NCI-H1048 NGC0eFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvyV3dmUUN3ME2yNU4zOjV6IN88US=> NGfLdXNUSU6JRWK=
CW-2 M1LiNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJzLkK3NFUh|ryP M2fhfHNCVkeHUh?=
HCC2157 NV3CU2RCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\vTWM2OD1{MT6zOkDPxE1? NEH3NmRUSU6JRWK=
EW-22 NUTsfI9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJzLkO3OkDPxE1? NYLjVo43W0GQR1XS
A253 MkjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3vVppKSzVyPUKxMlQ1QDFizszN MnfTV2FPT0WU
BE-13 NFflWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M12xemlEPTB;MkGuOlEyOyEQvF2= NGHoXotUSU6JRWK=
KINGS-1 M2\iZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HUcGlEPTB;MkGuOlMyPiEQvF2= MYfTRW5ITVJ?
ETK-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmixTWM2OD1{MT64NVUzKM7:TR?= M1TEXHNCVkeHUh?=
NCI-H2452 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJzLki2OFch|ryP NUPOe4dpW0GQR1XS
HPAF-II NI\MbmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj4Z4EzUUN3ME2yNU45QTJ|IN88US=> NVnpRmlJW0GQR1XS
D-542MG Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS4TWM2OD1{MT65NFY6KM7:TR?= MYHTRW5ITVJ?
NCI-H630 M2q4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\yTWM2OD1{Mj6wNlk3KM7:TR?= M1frNXNCVkeHUh?=
TGBC11TKB M3LBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3S1W2lEPTB;MkKuNFQ6KM7:TR?= NXzwWZhmW0GQR1XS
BCPAP NV;USmE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET6cItKSzVyPUKyMlYyOSEQvF2= MUHTRW5ITVJ?
HLE NITUVZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJ{Lk[5O{DPxE1? NF;hfHhUSU6JRWK=
NCI-H727 NHTkRpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJ{LkezOUDPxE1? M3S1d3NCVkeHUh?=
RD NF;3UXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfWfFBUUUN3ME2yNk44PTF6IN88US=> Mo\VV2FPT0WU
NCI-H522 M1nMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHQ[2d5UUN3ME2yNk45PDNzIN88US=> NILB[49USU6JRWK=
CGTH-W-1 NYLwOGs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrqdYV7UUN3ME2yN{4xPjRzIN88US=> Mn3QV2FPT0WU
SK-LU-1 MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP3NoVKSzVyPUKzMlQ3QDNizszN NGDtb49USU6JRWK=
BB65-RCC M2LXTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJ|Lke4OlMh|ryP NXTad|l4W0GQR1XS
HSC-3 M2K4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXOSop1UUN3ME2yN{45PTJ5IN88US=> MULTRW5ITVJ?
SK-MES-1 M13m[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\zVmlEPTB;MkSuNFE3OSEQvF2= MWHTRW5ITVJ?
DB NGf2XpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPZOnhnUUN3ME2yOE4yODJ6IN88US=> NGe5WmFUSU6JRWK=
HO-1-N-1 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLFSW9KSzVyPUK0MlMxQTNizszN MVfTRW5ITVJ?
MKN1 M{LodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPjVYFKSzVyPUK0MlY5KM7:TR?= Mn3TV2FPT0WU
MN-60 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\CTWM2OD1{ND64OVE6KM7:TR?= MVLTRW5ITVJ?
8505C MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJ3LkG4OFUh|ryP M1;KRnNCVkeHUh?=
COLO-320-HSR NILUd2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXJTWM2OD1{NT6yNlA5KM7:TR?= NVz4b2JUW0GQR1XS
BB30-HNC NFroNoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPmTI9KSzVyPUK1MlI1QDNizszN NFfrVGpUSU6JRWK=
KM12 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXCdWVKSzVyPUK1MlU5ODdizszN M2P1S3NCVkeHUh?=
NB13 NGX0UVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jWXGlEPTB;MkWuOVg6QCEQvF2= MljYV2FPT0WU
HCC2998 M2XjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ4LkCyPFMh|ryP MnO3V2FPT0WU
U-118-MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fvVWlEPTB;Mk[uNFgxQCEQvF2= MUXTRW5ITVJ?
NB10 NWmyVYszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILMZmxKSzVyPUK2MlI{PCEQvF2= NIPkZmhUSU6JRWK=
SK-LMS-1 MoLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPK[oZvUUN3ME2yO{4xPzB2IN88US=> NFvzfoJUSU6JRWK=
SW1573 M2e0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XJOWlEPTB;MkeuNVEh|ryP NEPK[mpUSU6JRWK=
LB373-MEL-D M3TpXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJ5LkGyPVQh|ryP NYL4V|R7W0GQR1XS
DK-MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTiWmZTUUN3ME2yO{4yQDF5IN88US=> NW\XfmJWW0GQR1XS
RMG-I M{TQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TDWGlEPTB;MkeuNlAzQSEQvF2= MkHSV2FPT0WU
SW1088 M4LWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TlUmlEPTB;MkeuOVA1OiEQvF2= NV7Xd|A5W0GQR1XS
SK-OV-3 Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXnTWM2OD1{Nz63OVk{KM7:TR?= NIDFWo5USU6JRWK=
KP-N-YN M4HubGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7YUJh6UUN3ME2yO{45ODR|IN88US=> Mk\lV2FPT0WU
RPMI-7951 NIOxOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrFTWM2OD1{OD6yOFU3KM7:TR?= NWTaN2tyW0GQR1XS
CaR-1 M{CyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTGW2QxUUN3ME2yPE42PTh{IN88US=> NEmwdlFUSU6JRWK=
MKN7 NGDuflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJ6LkW5OlQh|ryP MmD0V2FPT0WU
CHP-212 MkDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjtVpQ{UUN3ME2yPE44PDBzIN88US=> NXXadotkW0GQR1XS
KYSE-450 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH6TWM2OD1{OD64NFkyKM7:TR?= MV3TRW5ITVJ?
RXF393 NIrXUYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInOTm9KSzVyPUK5MlI6ODZizszN MmPFV2FPT0WU
P30-OHK M1Tsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXmWoxJUUN3ME2yPU4{ODR6IN88US=> M1LkUHNCVkeHUh?=
Ca9-22 M4L2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDXSmtKSzVyPUK5MlQzQTlizszN NW\FfZpqW0GQR1XS
RT-112 NV3wPHN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWr3N3I2UUN3ME2yPU41PjFzIN88US=> NXjF[WdKW0GQR1XS
ES1 NWDGRYhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTWTWM2OD1{OT64OVQ1KM7:TR?= NY\VemxVW0GQR1XS
HCE-4 M3j5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjKcWVKSzVyPUK5Mlg4QDZizszN MWnTRW5ITVJ?
AM-38 NI\WUG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jaTWlEPTB;M{CuNFYxPiEQvF2= M3jmOXNCVkeHUh?=
AsPC-1 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf3Vot3UUN3ME2zNE45ODV|IN88US=> MYPTRW5ITVJ?
TE-9 M{TMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rBPWlEPTB;M{CuPFc{PyEQvF2= NH6yTIpUSU6JRWK=
HuP-T4 NITNTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTNyLkm2N|gh|ryP MV3TRW5ITVJ?
LB2518-MEL NWXjSplIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXpbG5KSzVyPUOxMlA4PDRizszN NIXjU3JUSU6JRWK=
NCI-H1703 NVPTRlZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;4SWhSUUN3ME2zNU4xQTB3IN88US=> M3Tl[3NCVkeHUh?=
NCI-H2228 M2Xwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXkUJViUUN3ME2zNU41PjVzIN88US=> NGXtWXVUSU6JRWK=
SCC-4 MlnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTNzLkmxPFEh|ryP NYX0UpBiW0GQR1XS
KNS-81-FD M330VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3W2N2lEPTB;M{KuNFEzQCEQvF2= Ml\1V2FPT0WU
NTERA-S-cl-D1 M2H4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTN{LkC3N|kh|ryP MXnTRW5ITVJ?
Daoy NXi3cZVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv4N5lKSzVyPUOyMlA5OzhizszN MoezV2FPT0WU
ES4 NXnEeHJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN{LkO5NlIh|ryP M1vRT3NCVkeHUh?=
MHH-ES-1 M{LF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLVTWM2OD1|Mj60PFczKM7:TR?= NYnIXWpMW0GQR1XS
C-33-A M3LmWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInYPJBKSzVyPUOyMlc4OjhizszN NYTqRo0zW0GQR1XS
BHY MoPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j2UGlEPTB;M{KuPVQ6PSEQvF2= MoPlV2FPT0WU
Detroit562 NX\BfYRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjFUm12UUN3ME2zN{43PjV5IN88US=> NWm5RXM4W0GQR1XS
EW-1 NGrPUnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXyTWM2OD1|Mz65N|IzKM7:TR?= MX;TRW5ITVJ?
NCI-H1395 NHrCRXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4T4WGlEPTB;M{SuNFc6QSEQvF2= NWG5RmE6W0GQR1XS
KM-H2 Ml;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTN4LkS3OFMh|ryP MWTTRW5ITVJ?
NCI-H520 MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL6TWM2OD1|Nj63OVQyKM7:TR?= NYfXWGpoW0GQR1XS
D-392MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XxVWlEPTB;M{euN|M1PCEQvF2= MUjTRW5ITVJ?
NOMO-1 NUXkO2RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{OybmlEPTB;M{euPFA5QSEQvF2= MXrTRW5ITVJ?
TE-6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTN6LkGyOEDPxE1? M4n1SHNCVkeHUh?=
HT-3 M37tWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHye5pUUUN3ME2zPE41PDN4IN88US=> NF3sT3BUSU6JRWK=
RPMI-8226 Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj6TWM2OD1|OD65OVE6KM7:TR?= MmDEV2FPT0WU
U251 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTN7LkCxNlQh|ryP NXfUelYyW0GQR1XS
GCT NILa[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nIdGlEPTB;M{muNVg2OiEQvF2= M3vCcHNCVkeHUh?=
A431 Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[wVGlEPTB;M{muNVg6PCEQvF2= NVTHb2lmW0GQR1XS
TE-12 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf1co9FUUN3ME2zPU4zPDR6IN88US=> MWLTRW5ITVJ?
HMV-II M13qU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTETWM2OD1|OT61NFQ4KM7:TR?= MnrvV2FPT0WU
IST-MES1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTRyLkG1NFIh|ryP M1XaOXNCVkeHUh?=
SW13 NWi0bIhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH3TWM2OD12MD61NVkh|ryP M{n4d3NCVkeHUh?=
SF295 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\jfGlEPTB;NECuPFA3PiEQvF2= MVTTRW5ITVJ?
MDA-MB-157 M{LaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPiV5dKSzVyPUSwMlk1PjJizszN NFqzT3RUSU6JRWK=
TE-1 M2D3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\6fFZEUUN3ME20NU45PzF2IN88US=> M2q4N3NCVkeHUh?=
HuCCT1 NFnpO2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTR{LkWyPFkh|ryP MXfTRW5ITVJ?
KYSE-510 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTR|LkG3OVQh|ryP MVPTRW5ITVJ?
NCI-H358 M2nIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7PTWM2OD12ND6wN|A1KM7:TR?= NYK5dnFPW0GQR1XS
SW900 M4fn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPzTWM2OD12ND6wO|U5KM7:TR?= M1uye3NCVkeHUh?=
CAS-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;r[ZJ[UUN3ME20OE4xQTlzIN88US=> NXLzOWNGW0GQR1XS
TE-8 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLvTWM2OD12ND61OlU5KM7:TR?= NHvVdXdUSU6JRWK=
P12-ICHIKAWA NWn2VXc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m5OGlEPTB;NESuOlEyOiEQvF2= MkDkV2FPT0WU
YKG-1 NV\peXJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjyOIlKSzVyPUS0Mlc5OSEQvF2= MkXUV2FPT0WU
SNU-C2B M4D2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fYdmlEPTB;NESuO|kxOyEQvF2= MUnTRW5ITVJ?
LCLC-103H NHHjS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTR2Lki3NFMh|ryP Mkf0V2FPT0WU
U-87-MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2r3fWlEPTB;NEWuNVAzOiEQvF2= NYPIfZl6W0GQR1XS
HAL-01 NEHzRm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDlc4JKSzVyPUS1MlE{PzlizszN NWfCfYpLW0GQR1XS
OVCAR-8 MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PXOGlEPTB;NEWuN|U3PCEQvF2= NHnUfIVUSU6JRWK=
KYSE-150 M3HkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTR5LkGwOVIh|ryP NHLEW4tUSU6JRWK=
OE33 NHfJN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTR5LkG0Nlkh|ryP MV;TRW5ITVJ?
CAL-62 NXfN[HllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TiXWlEPTB;NEeuOFA3QCEQvF2= NE[2[pNUSU6JRWK=
TCCSUP MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXTOXpKSzVyPUS3MlYzPjRizszN NE\j[lRUSU6JRWK=
H4 NY\xSolUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvpTWM2OD12Nz62OlIyKM7:TR?= M3jvNHNCVkeHUh?=
CP66-MEL MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzHbW5KSzVyPUS4MlA4ODRizszN NULkcYFVW0GQR1XS
SNB75 NGHLZ2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXW4WFFSUUN3ME20PE4yQDd2IN88US=> NFPI[ZRUSU6JRWK=
Mo-T MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrRNoZ{UUN3ME20PE4zPzlizszN M3;ncXNCVkeHUh?=
BT-549 NV\nbIZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTR6LkO3Nlkh|ryP NH\qSY5USU6JRWK=
IGR-1 M4XSVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDxPWhLUUN3ME20PE43PjR3IN88US=> MYPTRW5ITVJ?
NCI-H1299 NFHZWGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L3fGlEPTB;NEiuO|I1QCEQvF2= NFjvdZJUSU6JRWK=
ALL-PO NVzrRW1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;GcnVKSzVyPUS5MlkzPjhizszN M{\KXnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 NU7441 intraperitoneally administrated at dose of 10 mg/kg maintains for at least 4 hours shows nontoxic and increases etoposide-induced tumor growth delay 2-fold in mice bearing SW620 xenografts. [2]
臨床試験
特集

プロトコル (参考用のみ)

細胞アッセイ: [2]

細胞株 SW620, LoVo, V3-YAC and V3 cells
濃度 0.5 μM or 1 μM
反応時間 17 hours
実験の流れ The effect of NU7441 on cellular survival following exposure to etoposide, doxorubicin, and ionizing radiation is measured in SW620, LoVo, V3, and V3-YAC cells by clonogenic assays. Briefly, growing cells in six-well plates or 6-cm dishes are exposed to etoposide or doxorubicin with or without NU7441 (0.5 or 1.0 μM) for 16 hours. For radiosensitization studies, NU7441 is added to the cells 1 hour before irradiation. V3 and V3-YAC cells are exposed to γ-irradiation (3.1 Gy/min 137Cesium). SW620 and LoVo are exposed to X-irradiation (2.9 Gy/min at 230 kV, 10 mA) due to the equipment available. After irradiation, the cells are incubated with or without NU7441 for a further 16 hours. Cells are then harvested by trypsinization, counted, and seeded into 10-cm diameter Petri dishes at densities varying from 100 to 105 per dish in drug-free medium for colony formation. Colonies are stained with crystal violet after 10 to 14 days and counted with an automated colony counter. The survival reduction factor (SRF) is calculated as the surviving fraction of cells in the absence of NU7441 divided by the surviving fraction of cells in the presence of NU7441 for any given dose or concentration of cytotoxic agent. The dose modification ratio (DMR90) is calculated as the concentration/dose of cytotoxic agent required to kill 90% of the cells in the absence of NU7441 divided by the concentration/dose of cytotoxic agent required to kill 90% of the cells in the presence of NU7441.

動物実験: [2]

動物モデル Female rude mice bearing SW620 xenografts
製剤 Sterile 0.9% sodium chloride solution
投薬量 10 mg/kg
投与方法 Intraperitoneally administrated

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download NU7441 (KU-57788) SDF
分子量 413.49
化学式

C25H19NO3S

CAS No. 503468-95-9
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 4 mg/mL warming (9.67 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

文献中の引用 (15)

Frequently Asked Questions

  • Question 1
    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

    Answer: Slight color variation due to different processing is normal and usually doesn't interfere with the function.

技術サポート&よくある質問(FAQ)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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