Gefitinib (ZD1839) 化学構造
分子量: 446.90

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Quality Control & MSDS

製品説明

  • Compare EGFR Inhibitors
    EGFR製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Gefitinib (ZD1839) は、NR6wtEGFRとNR6W細胞のTyr1173、Tyr992、Tyr1173とTyr992のためのEGFR阻害剤で、IC50 がそれぞれ 37 nM、 37nM、 26 nM 、57 nMです。
ターゲット Tyr1173 (NR6wtEGFR cells) Tyr992 (NR6wtEGFR cells) Tyr1173 (NR6W cells) Tyr992 (NR6W cells)
IC50 37 nM 37nM 26 nM 57 nM [1]
In vitro試験 Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low-EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Gefitinib effectively blocks the phosphorylation of PLC-γ, with IC50 of 27nM, in NR6W cells. The NR6wtEGFR and NR6M cell lines has low levels of PLC-γ phosphorylation but the level in the NR6M cell line is more resistant to inhibition by Gefitinib with IC50 of 43 nM and 369 nM, respectively. Gefitinib inhibits Akt phosphorylations, with IC50 of 220 and 263nM, in the low-EGFR- and -EGFRvIII-expressing cell lines, respectively. Gefitinib in the dose range from 0.1 to 0.5μM significantly facilitates, rather than abrogates, colony formation of NR6M cells. However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation. Gefitinib rapidly and in a dose-dependent manner inhibits EGFR and ERK phosphorylation up to 72 hours after EGF stimulation in both the high- and low-EGFR-expressing cell lines. [1] Gefitinib is the monolayer growth of these EGF-driven untransformed MCF10A cells with an IC50 of 20 nM. [2] The combination of Gefitinib (0.2 μM and 0.5 μM) with irradiation lead to a significant growth inhibition in LoVo cells, compared with radiation alone.. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
KB NH\qdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXrTWM2OD1yLkC1OEDPxE1? MlrkNVY2OTZ2N{O=
NIH3T3 MW\GeY5kfGmxbjDBd5NigQ>? NVfkZYZROC5{IN88US=> MYeyJIg> MY\EUXNQ NEK5fZNKdmirYnn0bY9vKG:oIFXHSkB{fGmvdXzheIVlKGi3bXHuJIVz[kJzIHH1eI9xcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEG0OEDPxE1? MXqxOlQ5ODJ6NB?=
COS7 NHSwOJJHfW6ldHnvckBCe3OjeR?= NV\3epZwQTZizszN M13Md2lvcGmkaYTpc44hd2ZiaIXtZY4hUkGNMjDWOlE4TiCvdYThcpQh\XiycnXzd4Vl NH;6d44yPzF5OEeyNi=>
A549 NF32XIlEgXSxdH;4bYMhSXO|YYm= NIDaUYc6PiCq NHzVdJZFVVOR MoTNTWM2OD1zMz61PUDPxE1? M3n3[lE5OzF|OEC3
K562 M1rxZWN6fG:2b4jpZ{BCe3OjeR?= M{HtdVk3KGh? MkfBSG1UVw>? NV7BVVhQUUN3ME25MlM3KM7:TR?= MmrTNVg{OTN6MEe=
MDA-MB-231 MV3DfZRwfG:6aXOgRZN{[Xl? NUflOotyQTZiaB?= MYXEUXNQ NGm4c|BKSzVyPUO2MlYyKM7:TR?= MV[xPFMyOzhyNx?=
MOLT4 NHr1SodEgXSxdH;4bYMhSXO|YYm= MnLPPVYhcA>? NGj0XI1FVVOR M3HDOWlEPTB;MUWuNFIh|ryP NEXmOJYyQDNzM{iwOy=>
MCF7 NHn2e2VEgXSxdH;4bYMhSXO|YYm= M2DtNlUxKM7:TR?= MXe3NkBp NHrDUnJKSzVyPUGyMlA2KM7:TR?= NVjoZY5LOTh5N{G4NVk>
BT474 NHjIZlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnKwO|IhcA>? MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKWNEe0JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWUQnKyJJdqfGhiRVO1NEBw\iByLkOg{txO NIXDVmoyQTB{OESyOC=>
HN5 M3j1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDyZWp2PzJiaB?= M{O3UWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSF61JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKEWJRmKge4l1cCCHQ{WwJI9nKDBwMEGg{txO NF[zVY0yQTB{OESyOC=>
BA/F3 NVLrflhzS3m2b4TvfIlkKEG|c3H5 NITHVmU4OiCq MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEWJRmKgUFg2QFJibYX0ZY51KHerdHigTWM2OCCxZjCwMlAyODhizszN MXmxPVI{QTJ{OR?=
NIH3T3 NWG2TZVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDCNm9tPzJiaB?= NVH5SHBGT3Kxd4ToJIlvcGmkaYTpc44hd2ZibX;1d4UhVkmKL{PUN{Bk\WyuczDlfJBz\XO|aX7nJIVzSjJiZ3Xu[UB4cXSqIFnDOVAhd2ZiMD61OEDPxE1? NVmxXZpxOTl4NkWzO|c>
MCF7 MX NWH1UW5PTnWwY4Tpc44hSXO|YYm= MmXJN|AhdWmw MXTJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJJdqfGhiSVO1NEBw\iBzLkGg{txO M3HOTlE6QTN{OU[w
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A431 MnT4T4lv[XOnIFHzd4F6 NYiyd2FROC5zIN88US=> NGXsdXEyKGh? MljRTY5pcWKrdHnvckBw\iCHR1[tbY5lfWOnZDDFS2ZTKHCqb4PwbI9zgWyjdHnvci=> M3jVOlE6QTZ7NE[1
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Sf9 NHztZ5JMcW6jc3WgRZN{[Xl? MV:xNEBucW5? MXrEUXNQ M3;yRWlvcGmkaYTpc44hd2ZiRVfGVkBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\WOncITvdkBifXSxcHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlA{OyEQvF2= NYTTcVBGOjByNU[0NlU>
NCI-H1975 M2[zcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX21JO69VQ>? MoH0O|IhcA>? M1[0bWlEPTB;OD6yOkDPxE1? MVGyNFE2OTZ5MB?=
NCI-H1975 NYrPTIt1U2mwYYPlJGF{e2G7 M2Xkd|ExKM7:TR?= MnfOTY5pcWKrdHnvckBw\iCHR1\SJIF2fG:yaH;zdIhwenmuYYTpc44> MViyNFE2OTZ5MB?=
NCI-H1975 MWTGeY5kfGmxbjDBd5NigQ>? NX;TVWR2OTBizszN M4fuTmlvcGmkaYTpc44hd2ZiRWLCRlIh[XW2b4Doc5NxcG:{eXzheIlwdg>? MXiyNFE2OTZ5MB?=
NCI-H1975 NWPaRoI5TnWwY4Tpc44hSXO|YYm= M3WyVFUh|ryP M2i1ZlQ5KGh? M4T1dmlv\HWldHnvckBw\iCjcH;weI9{cXNiYYPz[ZN{\WRiYYOgZYN1cX[jdHnvckBw\iClYYPwZZNmNTN? MoPGNlAyPTF4N{C=
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DU145 NEj2NFREgXSxdH;4bYMhSXO|YYm= MkLJOUBl NILoc41FVVOR MkfGTWM2OD12Mj6xO{DPxE1? MnrHNlA1PjZ3NUW=
MIAPaCa2 NX\zW2VnS3m2b4TvfIlkKEG|c3H5 MkPqOUBl NXjyU2JDTE2VTx?= M17jPWlEPTB;NUCuOlIh|ryP M3zqelIxPDZ4NUW1
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PC3 M4jUVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PNUVExKM7:TR?= MVu3NkBp M{m3T2ROW09? NF\rUoJKSzVyPUeuOEDPxE1? NWXhbHF7OjF|NUO1OFY>
MDA-MB-468 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTiNVAxKM7:TR?= MYq0PEBp MkT1SG1UVw>? NF\kPY1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fS=> MYWyNVQzQTZ|Mh?=
Plasmodium falciparum MlXDdWhVWyCycn;mbYxqdmdiZn;yJIlvcGmkaYTvdpMhd2ZiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJJBzd2yrZnXyZZRqd25? MlrmNlE5OTdyNEW=
NCI-H1993 NUDDUZFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrkRW5{PzJiaB?= NVjOTVd{TE2VTx?= M3PjUmlEPTB;MD6xJO69VQ>? MUOyNVkyPjR|Mx?=
NCI-H292 M3;QXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf4VIxNPzJiaB?= NXrKeYRNTE2VTx?= NYPFPVJHUUN3ME2wMlAzKM7:TR?= NVzJdGF[OjF7MU[0N|M>
A431 NIjjdJNMcW6jc3WgRZN{[Xl? MUiyJIg> M1XnXWROW09? M1XTOGlvcGmkaYTpc44hd2ZiRVfGVkBxcG:|cHjvdplt[XSrb36gbY4hTUeILYP0bY12dGG2ZXSgbJVu[W5iQUSzNUB4cXSqIFnDOVAhd2ZiMD6wNFEh|ryP MmPMNlIyODFzM{K=
MCF7 NV3xfm1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[xNFDDqM7:Zz;tUC=> MnH5OFghcA>? MnjlSG1UVw>? MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDn[Y5mKHerdHigTWM2OCCxZjCxNk4xPSEQvF2= NWnUSZlLOjJzMUmxN|A>
BT474 MmLHR5l1d3SxeHnjJGF{e2G7 NIHBbooyOCEQvF2= MnrEOFghcA>? NXHpblhDS3m2b4TvfIlkcXS7IHHnZYlve3Ric3XyeY0ue3Sjco\l[EBpfW2jbjDCWFQ4PCClZXzsdy=> MnvNNlIyOzh|MEi=
MCF7 NG[yU3REgXSxdH;4bYMhSXO|YYm= M{LkdFExKM7:TR?= NH7pcWI1QCCq Mn6wR5l1d3SxeHnjbZR6KGGpYXnud5Qhe2W{dX2td5Rien[nZDDoeY1idiCPQ1[3JINmdGy|IH;2[ZIu\XiycnXzd4lv\yCHcnLCNkBk\Wyucx?= M3HCdVIzOTN6M{C4
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HCC827 NXvxWFlxU2mwYYPlJGF{e2G7 MYSwMlEzPSEQvF2= MYWyOEBp MUDEUXNQ NUDSWJdbUW6qaXLpeIlwdiCxZjDFS2ZTKGSnbDDFO|Q3NUF5NUCgcZV1[W62LX3l[IlifGWmIFHreEBxcG:|cHjvdplt[XSrb36= MVOyNlM{QTN2Mh?=
A431 MlTKT4lv[XOnIFHzd4F6 MonlNVAxKM7:TR?= M33J[VMxKG2rbh?= M3zDTWlvcGmkaYTpc44hd2ZiRVfGVkBl\XKrdnXkJIZzd21iaIXtZY4hSTR|MTDj[YxtKG2nbXLyZY5mKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheG:ueT3HcJUuXHm{IIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNU4xQCEQvF2= MXiyNlY6QDd6Mh?=
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HT-29 NUXEeoFCS3m2b4TvfIlkKEG|c3H5 M36xNlczKGh? MVfJR|UxRTNwM{[g{txO MkToNlI4Ojd2NEm=
SGC7901 NWG1RoJwS3m2b4TvfIlkKEG|c3H5 MV:3NkBp Mn7NTWM2OD1zMD6yOkDPxE1? MVGyNlczPzR2OR?=
A498 M13Ec2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXqxdIpqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFk5KGOnbHzzJIV5eHKnc4PpcochTUeIUjDhcoQhW1KFIIfpeIghUUN3MDDv[kA5NjZizszN MV:yNlgyQDh2OB?=
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A549 M2ruT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfNU5ZpPzJiaB?= M4TvUGROW09? NGC0eIlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JJdqdGRidInw[UBGT0[UL3utVoF{KGSncHXu[IVvfCCqdX3hckBCPTR7IHPlcIx{KHerdHigTWM2OCCxZjC0MlYzPiEQvF2= NF7zXJIzOzd7MkOxPC=>
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KYSE-180 NHfCeZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTV|MD62NkBvVQ>? M3\sNXNCVkeHUh?=
NCI-H82 NE\odlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXCRoNKSzVyPUW0NE42KG6P NIDUfoFUSU6JRWK=
NB7 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjqXXh2UUN3ME21OFYvOzJibl2= MYDTRW5ITVJ?
DSH1 NIPWOIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn3TldiUUN3ME21OlYvQDhibl2= MnqzV2FPT0WU
RS4-11 MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTV4OD61PUBvVQ>? NGXYXWVUSU6JRWK=
CAN M1XhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorvTWM2OD13OECuO|Yhdk1? MVXTRW5ITVJ?
Ca9-22 M3uyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXsTWM2OD13OEiuOlQhdk1? NIfVUmdUSU6JRWK=
CAL-39 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fPb2lEPTB;NUm2MlMhdk1? NUnGclYyW0GQR1XS
NCI-H1623 NXG4ZmIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjCU|AyUUN3ME21PVkvOzZibl2= Mo\UV2FPT0WU
FADU NUnpW2ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzVSZhYUUN3ME22NFQvPjlibl2= M13VSXNCVkeHUh?=
NB69 MnrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrRTWM2OD14MUSuN|Uhdk1? NXPsVmVIW0GQR1XS
Ramos-2G6-4C10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DEWmlEPTB;NkKxMlQ3KG6P Ml3kV2FPT0WU
LB1047-RCC NULjXnFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvrTWM2OD14MkWuNlkhdk1? MV;TRW5ITVJ?
MV-4-11 NH3k[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPaTWM2OD14MkeuO{BvVQ>? MoHWV2FPT0WU
DBTRG-05MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT6OFBKSzVyPU[zNk4zQCCwTR?= MnTkV2FPT0WU
ME-180 MlS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTZ|Mj65JI5O NH7SSIpUSU6JRWK=
NBsusSR MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPLdFhKSzVyPU[0Ok42OiCwTR?= NHzBdldUSU6JRWK=
COR-L105 M4LBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPVTWM2OD14NkKuOVMhdk1? M2C2XXNCVkeHUh?=
ETK-1 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTaTWM2OD14NkKuOVkhdk1? NHrY[lVUSU6JRWK=
L-363 Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTZ5MT65OEBvVQ>? MVzTRW5ITVJ?
LU-134-A NYT2WWN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTJTWM2OD15MUmuNFkhdk1? NFezb4NUSU6JRWK=
NCI-H1770 NWruZlNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP6botEUUN3ME23NlIvPCCwTR?= NVLCV24xW0GQR1XS
HAL-01 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme3TWM2OD15M{SuO|Ehdk1? Ml7XV2FPT0WU
COLO-684 NXHKNoxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTd3Mz6wNUBvVQ>? NGjHeVFUSU6JRWK=
TE-6 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrwTYZKSzVyPUe2OE4{OSCwTR?= M1;mNXNCVkeHUh?=
A431 NV7w[HE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTd6MD6wOEBvVQ>? NU\qZWtkW0GQR1XS
LU-135 MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPlTWM2OD15OEOuNFMhdk1? M3XPO3NCVkeHUh?=
EC-GI-10 MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Tuc2lEPTB;N{i4MlUzKG6P M33jPHNCVkeHUh?=
TE-12 NUPseohnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTh{MT6xNUBvVQ>? NFvRd5lUSU6JRWK=
LoVo M3;JfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTh3OT6wOkBvVQ>? MV;TRW5ITVJ?
23132-87 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTh4ND6yPEBvVQ>? NFTMW4RUSU6JRWK=
AU565 NEXTVIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTh4OT62JI5O NYHEfIo4W0GQR1XS
DEL NVLYc|E{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[5W5l5UUN3ME24O|cvPjVibl2= M3fPNXNCVkeHUh?=
COR-L88 MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPwTWM2OD16OEKuNlYhdk1? NGnOUYZUSU6JRWK=
NCI-H2126 NHS4[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3iTWM2OD16OEKuPFMhdk1? NYP2[|l1W0GQR1XS
CAPAN-1 NH7zSoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTh6Mz6yPUBvVQ>? NWnQe2JIW0GQR1XS
BT-474 NE\wSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnu1TWM2OD17M{iuNVQhdk1? NUXmcWtUW0GQR1XS
BHY NFLTc4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlyyTWM2OD17N{WuOFghdk1? Mln3V2FPT0WU
HT-3 NX7NWZVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTl6Mj60NUBvVQ>? NELve5NUSU6JRWK=
SK-NEP-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH6TWM2OD17OEmuOFQhdk1? Mo\1V2FPT0WU
MS-1 NYflT2FTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvPTWM2OD17OUSuOlkhdk1? MnzGV2FPT0WU
DOHH-2 M4ntd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz1RpNXUUN3ME2xMlAxODJzIN88US=> NXnJcHdWW0GQR1XS
NCI-H1304 NGm2SXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFraW3pKSzVyPUGuNFE3PDNizszN MkXJV2FPT0WU
EM-2 M3fD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfCVZJKSzVyPUGuNFMxOTZizszN NYjoeYszW0GQR1XS
MHH-PREB-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTFwMEi0OVEh|ryP MWPTRW5ITVJ?
KU-19-19 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnKT2tKSzVyPUGuNFg2PDFizszN NEPQNIFUSU6JRWK=
NCI-H1648 M1n1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfIOGliUUN3ME2xMlExPjF4IN88US=> NULMcWhbW0GQR1XS
MKN1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPIVnpKSzVyPUGuNlE6QDdizszN NFTEd4ZUSU6JRWK=
SNU-449 MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTFSoVSUUN3ME2xMlIzOjB6IN88US=> MnjjV2FPT0WU
OAW-42 Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTFwMke4NlUh|ryP NVyxeXpPW0GQR1XS
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SW1088 NVHYPFRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;VemlEPTB;MT6yPVYxPyEQvF2= MmHOV2FPT0WU
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CTV-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfmd3RKSzVyPUGuN|A5KM7:TR?= NHn3dHJUSU6JRWK=
NCI-H1092 NF\4WWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTFwM{C4OUDPxE1? M376WHNCVkeHUh?=
NKM-1 M{XQfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHVW5NYUUN3ME2xMlMzPTl5IN88US=> MojRV2FPT0WU
NCI-H1650 NWW1TVh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7BbW5KSzVyPUGuN|M1QDJizszN M{H3cXNCVkeHUh?=
SW954 M1jHXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTFwM{SwOFgh|ryP M{PuPXNCVkeHUh?=
SW48 NGrTWFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHuTWM2OD1zLkO2OlE5KM7:TR?= NE\yRXNUSU6JRWK=
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KMOE-2 NHf2VGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTGcHVKSzVyPUGuN|k5OTVizszN Mm\oV2FPT0WU
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CCRF-CEM NYnUZWNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{i2TmlEPTB;MT60NVEyKM7:TR?= NGHp[JRUSU6JRWK=
RH-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIruTZlKSzVyPUGuOFEyOzZizszN NITw[2VUSU6JRWK=
NCI-H526 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPQSJRCUUN3ME2xMlQ{QDJ4IN88US=> NX\VRVR5W0GQR1XS
697 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFwNESxNFQh|ryP M1HrV3NCVkeHUh?=
J82 NYq3O4pKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEe1TpRKSzVyPUGuOFU4PjZizszN NIfQWINUSU6JRWK=
BE-13 M2\sUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HkW2lEPTB;MT61NFY4OSEQvF2= NWTOXYJnW0GQR1XS
SAS NEHPb2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTFwNUG2NlIh|ryP M3Lad3NCVkeHUh?=
SCC-25 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFztWHZKSzVyPUGuOVI{OjJizszN NInxdIJUSU6JRWK=
LAMA-84 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFwNUO4NVUh|ryP NIG1PVdUSU6JRWK=
HSC-3 NXzFXJZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TIXGlEPTB;MT61OFM5KM7:TR?= NIDhPHFUSU6JRWK=
BT-549 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDXXJdKSzVyPUGuOVg4PDdizszN NV;kd3lCW0GQR1XS
ML-2 MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PHfmlEPTB;MT62OFAzQSEQvF2= MWDTRW5ITVJ?
BB30-HNC NFHvWmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnOZ|RSUUN3ME2xMlY5QTd{IN88US=> MUnTRW5ITVJ?
PANC-03-27 NXjJbodLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PlNmlEPTB;MT63NFE{QSEQvF2= MUDTRW5ITVJ?
COLO-678 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLCTWM2OD1zLkezOFQ1KM7:TR?= NV3ZPZExW0GQR1XS
NCI-H1666 Ml7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEiy[XFKSzVyPUGuO|Q4ODRizszN NWnGenB1W0GQR1XS
NCI-H209 M1PQNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDVcoZLUUN3ME2xMlc4OjZ7IN88US=> NXXxTo9JW0GQR1XS
EPLC-272H M3qzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\rRpZGUUN3ME2xMlg2PTR7IN88US=> MXLTRW5ITVJ?
OMC-1 M1TTPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHTV2ZKSzVyPUGuPVk5QDhizszN Mli1V2FPT0WU
HCC70 MkXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJwMEC4NVUh|ryP NVnJcVlWW0GQR1XS
CAL-12T MnnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorlTWM2OD1{LkCxPFYyKM7:TR?= NIm1WHpUSU6JRWK=
TGBC24TKB M4nP[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLDTWM2OD1{LkCyPVYyKM7:TR?= NVHWUYh4W0GQR1XS
EKVX NVexV5YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDsVWdXUUN3ME2yMlA1QTN7IN88US=> Mof1V2FPT0WU
SW1116 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJwME[wNFkh|ryP M4PUeXNCVkeHUh?=
NCI-H2009 NX23V294T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnjcmxKSzVyPUKuNFYzOTRizszN NGjiSlZUSU6JRWK=
RPMI-8866 M3j4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nFdmlEPTB;Mj6wPFQ5OSEQvF2= M4P1W3NCVkeHUh?=
KARPAS-45 MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfEVZRWUUN3ME2yMlEzPDd7IN88US=> Mn;HV2FPT0WU
RXF393 NGXjUY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHsTWM2OD1{LkGzNFM3KM7:TR?= M1XZUXNCVkeHUh?=
786-0 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPPTWM2OD1{LkG4OFA3KM7:TR?= MmnWV2FPT0WU
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BT-20 NHLOPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTJwMk[3OFQh|ryP MWXTRW5ITVJ?
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JVM-3 NV;EO4p1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\aTWM2OD1{LkO0OlQ{KM7:TR?= MUnTRW5ITVJ?
NCI-H2170 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDpfG1KSzVyPUKuN|Q4QDNizszN NEXXRoFUSU6JRWK=
EW-18 NE\sNolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlewTWM2OD1{LkO1OFcyKM7:TR?= NYjnfFZPW0GQR1XS
KU812 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO5[3FoUUN3ME2yMlM3Pzd7IN88US=> MV\TRW5ITVJ?
NY MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X3W2lEPTB;Mj6zO|I4KM7:TR?= MnznV2FPT0WU
HTC-C3 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37hOWlEPTB;Mj60NlI3PyEQvF2= MkjNV2FPT0WU
CFPAC-1 M3fpUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fTTGlEPTB;Mj60N|g3PCEQvF2= MYHTRW5ITVJ?
HH MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHRXHhKSzVyPUKuOFk5PTRizszN MnrtV2FPT0WU
MKN7 Mm\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LUXWlEPTB;Mj62Nlc1QCEQvF2= MUXTRW5ITVJ?
TE-8 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TTRWlEPTB;Mj62N|Y2OyEQvF2= NW\ZfVF4W0GQR1XS
MC-IXC Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[wTWM2OD1{Lk[0OFU{KM7:TR?= MULTRW5ITVJ?
DMS-79 MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{SxUWlEPTB;Mj62PVI5PCEQvF2= Mm\1V2FPT0WU
Detroit562 Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PmfmlEPTB;Mj62PVg1PSEQvF2= NHmwc5RUSU6JRWK=
HuP-T4 MkTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVSxOGNHUUN3ME2yMlczQDF6IN88US=> M2rxXXNCVkeHUh?=
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BB65-RCC M3v1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJwOEC3NVMh|ryP M3\GUXNCVkeHUh?=
PC-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vBOmlEPTB;Mj64N|MyPyEQvF2= MXvTRW5ITVJ?
OVCAR-3 MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TnfWlEPTB;Mj64OVU6PCEQvF2= NI\wVFdUSU6JRWK=
KYSE-510 NETldmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37OWmlEPTB;Mj64Olc5PiEQvF2= NGj0V5dUSU6JRWK=
HC-1 M3W2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXPTWM2OD1{Lkm0NFEzKM7:TR?= NIC0XVJUSU6JRWK=
NCI-H1693 M3jkVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rhV2lEPTB;Mj65OVg6PyEQvF2= MVfTRW5ITVJ?
DU-4475 NVT3TmpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfjVIhKSzVyPUKuPVkxPTJizszN MnnaV2FPT0WU
COLO-680N M1z0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zuN2lEPTB;Mz6wNFQ6PSEQvF2= NITRSpFUSU6JRWK=
MN-60 NFHVflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNwMES5O|Qh|ryP M2rYb3NCVkeHUh?=
BCPAP M4C4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Pud2lEPTB;Mz6wPFI6PSEQvF2= NWPqZ416W0GQR1XS
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HT-1376 NUi4OIt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUCzTJNzUUN3ME2zMlIxPTB4IN88US=> NUHlN|MyW0GQR1XS
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YKG-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJzLk[1OFUh|ryP NYfETppqW0GQR1XS
CAL-85 NF\sW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXFNWlKUUN3ME2yNU46OzB3IN88US=> M1LNW3NCVkeHUh?=
NCI-H2347 NXXC[mh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TTcWlEPTB;MkGuPVQzQCEQvF2= MoPIV2FPT0WU
PANC-08-13 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUO5UmdvUUN3ME2yNk4xOTF7IN88US=> NXq1TVN5W0GQR1XS
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NEC8 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;pboZKSzVyPUKyMlUxPzhizszN M4mxVnNCVkeHUh?=
AN3-CA MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkiyTWM2OD1{Mj62NFg1KM7:TR?= NVTyUZFbW0GQR1XS
HuO9 MnvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfLRWVVUUN3ME2yNk44Ozl4IN88US=> MnTYV2FPT0WU
COLO-800 NYPyb5NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;Rd2ZyUUN3ME2yNk44PjV|IN88US=> MVnTRW5ITVJ?
HT-29 M{fPRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfEOVU4UUN3ME2yNk45QDJ|IN88US=> NVvvbGQyW0GQR1XS
OC-314 MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qwfGlEPTB;MkKuPFg1PSEQvF2= M17qT3NCVkeHUh?=
G-401 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTZTWM2OD1{Mz6wOFYzKM7:TR?= NVz0[3h6W0GQR1XS
Saos-2 NVfJXFVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS5PZpVUUN3ME2yN{42OTh{IN88US=> NIPzRYZUSU6JRWK=
UACC-62 NViwT|Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonPTWM2OD1{Mz61PFM{KM7:TR?= NWT1TGNsW0GQR1XS
D-247MG M37zT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX5XVduUUN3ME2yN{44QTN7IN88US=> M1TI[XNCVkeHUh?=
COLO-741 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\STWM2OD1{Mz65OVY2KM7:TR?= NXvHZm5wW0GQR1XS
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SW1710 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T6UGlEPTB;MkSuNVUxPiEQvF2= NVfpcW5lW0GQR1XS
LU-99A MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJ2LkG4OFEh|ryP M1fL[HNCVkeHUh?=
HOP-92 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfyXHNKSzVyPUK0MlczPSEQvF2= Mk\PV2FPT0WU
LS-123 NIXlfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJ2Lkm2NVQh|ryP MWnTRW5ITVJ?
T84 NUHvW5dJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mny1TWM2OD1{ND65O|Y2KM7:TR?= MVzTRW5ITVJ?
HCT-116 M{nSTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ3LkSxPFYh|ryP M3LX[HNCVkeHUh?=
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OCUB-M NF7ofFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJ3LkS0OVYh|ryP NYnkfFl3W0GQR1XS
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LCLC-97TM1 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\rdGJHUUN3ME2yOU44Ojh3IN88US=> NGj5c3VUSU6JRWK=
RVH-421 M1:5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TifmlEPTB;MkWuPFE3OSEQvF2= MmflV2FPT0WU
NKS-81-FD MlvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnziTWM2OD1{NT65NFIyKM7:TR?= M4rKXHNCVkeHUh?=
NCI-H596 NF3CVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLkOmFTUUN3ME2yOk4xPDh5IN88US=> MnjZV2FPT0WU
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ZR-75-30 Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXWd4J2UUN3ME2yOk4zOjl5IN88US=> M4C3e3NCVkeHUh?=
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HuP-T3 NHTFOYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJ4Lk[xNFIh|ryP NI\XUmFUSU6JRWK=
MOLT-16 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fLUGlEPTB;Mk[uOlE3PiEQvF2= MYjTRW5ITVJ?
U-87-MG MmeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjETWM2OD1{Nj63OFM5KM7:TR?= M4fFOHNCVkeHUh?=
8505C M3;IWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXs[nVyUUN3ME2yOk46OTJ4IN88US=> NH;vfJVUSU6JRWK=
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COLO-824 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonYTWM2OD1{Nz6yNVk2KM7:TR?= M3rDcXNCVkeHUh?=
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Hs-578-T M{HCcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT5NIxvUUN3ME2yO{42Ojl7IN88US=> NIjYO|ZUSU6JRWK=
UACC-893 MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJ5Lk[2N|Eh|ryP MlHNV2FPT0WU
MHH-NB-11 M4PScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnjWZBWUUN3ME2yO{45ODB5IN88US=> MWrTRW5ITVJ?
KYSE-410 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfp[VM1UUN3ME2yPE4zPzd7IN88US=> NGDqfFBUSU6JRWK=
SF126 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13POGlEPTB;MkiuO|Q{PSEQvF2= NX3VU49lW0GQR1XS
HT-144 NGTTO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;6XWQ2UUN3ME2yPU4{OzZ{IN88US=> M4qwdHNCVkeHUh?=
SW1573 NV3YdmdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYKzZoo1UUN3ME2yPU4{PTB7IN88US=> NX\1cWVzW0GQR1XS
SW620 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzhOJhxUUN3ME2yPU4{PjRzIN88US=> NUnCNm84W0GQR1XS
SCH MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJ7Lki4N|Eh|ryP M1v1cnNCVkeHUh?=
EW-22 NXzGT|l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPHTWM2OD1|MD6xPVY6KM7:TR?= NXL1eWVFW0GQR1XS
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CAS-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjzTWM2OD1|MD63PFU6KM7:TR?= NXmxcIx7W0GQR1XS
MG-63 M1\MfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTNyLki0O|gh|ryP MofOV2FPT0WU
MDA-MB-415 M1LmWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjtTWM2OD1|MT6xO|U{KM7:TR?= M1H4THNCVkeHUh?=
NCI-H1395 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTNzLkKzNlgh|ryP M4XmcHNCVkeHUh?=
Ca-Ski NFHTS21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTNzLkOxO|ch|ryP MnnSV2FPT0WU
BxPC-3 NIj3S5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fue2lEPTB;M{GuN|czQSEQvF2= M3e2TnNCVkeHUh?=
A3-KAW MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTNzLkS0O|Eh|ryP MWnTRW5ITVJ?
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NCI-H2029 MoHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;WTWM2OD1|MT63O|Y2KM7:TR?= NEXP[m9USU6JRWK=
YAPC M1TFbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPOTWM2OD1|Mj6wOFA4KM7:TR?= M2PIcXNCVkeHUh?=
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LS-513 M2DyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TDeGlEPTB;M{KuNVE5PyEQvF2= MX7TRW5ITVJ?
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KYSE-150 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;rTWM2OD1|Mj6zO|c{KM7:TR?= MVjTRW5ITVJ?
NCI-H520 NGXkeJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPnS2xKSzVyPUOyMlQ1QDJizszN Ml73V2FPT0WU
JEG-3 NX;6fpRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHqfppEUUN3ME2zN{4xQTdzIN88US=> MWTTRW5ITVJ?
GMS-10 NWO0N|V2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTN|LkOwNFQh|ryP M2PT[3NCVkeHUh?=
HT-1080 NEXQdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfY[mhKSzVyPUOzMlM6KM7:TR?= M1TJbXNCVkeHUh?=
NCI-H1651 MmSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDWW|JoUUN3ME2zN{4{QTZizszN NGTWe4xUSU6JRWK=
NCI-H2122 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjPUHdKSzVyPUOzMlU2PzRizszN NHPEVlJUSU6JRWK=
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8305C MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTN|Lkm5N|ch|ryP MXzTRW5ITVJ?
KM12 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\zdoxKSzVyPUO0MlA1PzhizszN MonPV2FPT0WU
HCT-15 MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTYRnZKSzVyPUO0MlEzPyEQvF2= MVHTRW5ITVJ?
OVCAR-5 M37pfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTN2LkKxPFIh|ryP NHWwVHZUSU6JRWK=
NCI-H2291 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnKNIZKSzVyPUO0MlI1PzJizszN NHXLPZdUSU6JRWK=
CP50-MEL-B MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\OTWM2OD1|ND62OVkzKM7:TR?= NFXRW5FUSU6JRWK=
C-33-A NFr3O|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTN2Lk[4OVch|ryP M4HWOHNCVkeHUh?=
NCI-H2452 M3PFSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjDTWM2OD1|ND63PFgzKM7:TR?= MlTDV2FPT0WU
MDA-MB-157 MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN2LkixPVMh|ryP NF\4T2NUSU6JRWK=
LN-405 NIXESG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYH5[mp4UUN3ME2zOU41OzB6IN88US=> Mn;mV2FPT0WU
MDA-MB-231 MmTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTN3LkWwOVQh|ryP MWXTRW5ITVJ?
EW-24 MlHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7jfVlKSzVyPUO1MlY{OzVizszN MknyV2FPT0WU
MKN28 MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEe1Z|dKSzVyPUO1MlgzOzZizszN NWjZeXoxW0GQR1XS
KINGS-1 NYPpeXlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXxZ2FFUUN3ME2zOU45PDN2IN88US=> Mn2wV2FPT0WU
LC-2-ad NFrnS2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3POemlEPTB;M{[uOlk6KM7:TR?= NEnG[4xUSU6JRWK=
IGR-1 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjNTWM2OD1|Nj63NFc2KM7:TR?= Moq5V2FPT0WU
SW626 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;nTWM2OD1|Nz6wOFE4KM7:TR?= MYnTRW5ITVJ?
ONS-76 M1zhbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfxWYE5UUN3ME2zO{4yOzB7IN88US=> MoqwV2FPT0WU
T98G NUfpfY9IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zK[2lEPTB;M{euPFY{PSEQvF2= M1m4eXNCVkeHUh?=
NB14 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PwXmlEPTB;M{iuOFU1PCEQvF2= NXPnSVRGW0GQR1XS
D-423MG NFPFVVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfybW1KSzVyPUO4MlQ5PjlizszN NYjnWGJmW0GQR1XS
NCI-H510A NUjJZpRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LwbmlEPTB;M{iuOlQ2OSEQvF2= MkD2V2FPT0WU
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SW948 NHfCb4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XmWmlEPTB;M{iuPFk1QSEQvF2= MlPuV2FPT0WU
MFM-223 M2m2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLtcGtQUUN3ME2zPE46PDNzIN88US=> MUDTRW5ITVJ?
PAN1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXviPYVUUUN3ME2zPE46QTF7IN88US=> MYjTRW5ITVJ?
MZ7-mel NYDj[5A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3JTpN4UUN3ME2zPU4yOTl7IN88US=> NUTScYJUW0GQR1XS
COLO-679 M1PC[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN7Lkm3NFgh|ryP M4rhXHNCVkeHUh?=
SW872 NEHscIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHzTWM2OD12MD6yNFMyKM7:TR?= NXvlNmJ7W0GQR1XS
HT-1197 NIn0d5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTRyLkK4Olkh|ryP M4X0enNCVkeHUh?=
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SNU-387 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi2SoI1UUN3ME20NE45OjN6IN88US=> Mo\UV2FPT0WU
T47D NX3mSIQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37OO2lEPTB;NEGuNFE6OiEQvF2= M371fHNCVkeHUh?=
G-402 NGfSdYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTRzLkC4NFkh|ryP MlvzV2FPT0WU
MZ1-PC NIToN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnUTWM2OD12MT64NUDPxE1? MnHiV2FPT0WU
SW1417 NHTxNmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHaTWM2OD12Mj6zNFMh|ryP MWDTRW5ITVJ?
RERF-LC-MS M4TPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTR{LkWwPFch|ryP MlPkV2FPT0WU
SF539 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUezfIZ1UUN3ME20Nk42PTJ7IN88US=> NWTXZW44W0GQR1XS
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RO82-W-1 NVmyTXJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnnTWM2OD12Mz62NVU{KM7:TR?= MmW1V2FPT0WU
S-117 NXTVemdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjZVFZnUUN3ME20N{43QTV6IN88US=> NY\zUIhyW0GQR1XS
SW756 NFLuUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfa[|hCUUN3ME20N{45OjR{IN88US=> NI\MdXlUSU6JRWK=
CP66-MEL NYLBUVlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDmTWM2OD12NT63NVQ{KM7:TR?= NVXUUIF1W0GQR1XS
H-EMC-SS NGezS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnq[oN3UUN3ME20OU44Pjl|IN88US=> MXfTRW5ITVJ?
NCI-H2052 M4DkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHmTWM2OD12NT65NFI4KM7:TR?= NEjWclVUSU6JRWK=
SW684 NEXXSFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTR5LkCwPFEh|ryP Ml\NV2FPT0WU
HCC1569 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLx[YxKSzVyPUS3MlE3PThizszN NWCzXod4W0GQR1XS
KGN MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonGTWM2OD12Nz6zN|EyKM7:TR?= Ml64V2FPT0WU
LCLC-103H M3;yN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf4TWM2OD12Nz60OFA1KM7:TR?= NVj0Uo9GW0GQR1XS
SW780 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTR5Lk[zOVEh|ryP MUfTRW5ITVJ?
NCI-H1703 Mnj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3qTWM2OD12OD6zN|UzKM7:TR?= NVTy[|ZHW0GQR1XS
HCC1395 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojUTWM2OD12OD63OFMzKM7:TR?= NEnvTGhUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts. [3] Gefitinib treatment of nude mice bearing established human GEO colon cancer xenografts reveals a reversible dose-dependent inhibition of tumor growth because GEO tumors resumes the growth rate of controls at the end of the treatment. [4]
臨床試験 Gefitinib has entered in a phase II clinical trial in the treatment of non small cell lung cancer.
特集 A potent EGFR tyrosine kinase inhibitor.

プロトコル (参考用のみ)

細胞アッセイ: [1]

細胞株 NR6, NR6M and NR6W cells
濃度 0-2 μM
反応時間 72 hours
実験の流れ Exponentially growing cells including NR6, NR6M, NR6M and NR6W cells are seeded in sextuple in 96-well plates at a concentration of 2000 cells/well, allowed to adhere and subsequently washed in PBS and incubated overnight in medium containing 0.5% FCS. Cells are then treated with varying concentrations (0-2 μM) of Gefitinib or the solute control DMSO and EGF. The optimal EGF concentration for inducing proliferation of NR6wtEGFR and NR6W cells has previously been determined and hence NR6wtEGFR and NR6W cells are supplemented with 10 nM and 0.1 nM EGF, respectively. EGF is not added to NR6 and NR6M cells. After 72 hours the amount of cells are measured by performing a MTT proliferation assay.

動物実験: [3]

動物モデル Female nude mice (cba nu/nu) aged 8–10 weeks are intra-dermal injected with LoVo cells.
製剤 0.5% polysorbate
投薬量 100 mg/kg
投与方法 Once daily by oral administration (0.1 mL/10 g body weight) for 14 days

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Gefitinib (ZD1839) SDF
分子量 446.90
化学式

C22H24ClFN4O3

CAS No. 184475-35-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 89 mg/mL (199.14 mM)
エタノール 4 mg/mL (8.95 mM)
<1 mg/mL (<1 mM)
In vivo 5% DMSO+corn oil 2.5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine

文献中の引用 (90)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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