Pictilisib (GDC-0941) 化学構造
分子量: 513.64

高品質保証

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Quality Control & MSDS

製品説明

  • Compare PI3K Inhibitors
    PI3K製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法
  • Pictilisib (GDC-0941)のメカニズム

製品の説明

生物活性

製品説明 Pictilisib (GDC-0941)は、PI3Kα、PI3Kβ、PI3KδとPI3Kγの強力な阻害剤で、IC50 がそれぞれ 3 nM、 33 nM、 3 nM、75 nMです。
ターゲット PI3Kα PI3Kβ PI3Kδ PI3Kγ
IC50 3 nM 33 nM 3 nM 75 nM [1]
In vitro試験 GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
Sf9 NYfQ[5R2U2mwYYPlJGF{e2G7 NFfseZoyKGh? Ml\JSG1UVw>? NFfEOnRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHTlcJRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlAxOyEQvF2= M1fnelE5PzV2NkW0
Sf9 M2W3V2tqdmG|ZTDBd5NigQ>? MlLVNUBp M2C4cGROW09? NEezWGhKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhUDFyNEetVkBufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? Mn7MNVg4PTR4NUS=
Sf9 MUPLbY5ie2ViQYPzZZk> NVvWXG44OSCq M{HIPWROW09? Mm\sTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> NUTNUmExOTh5NUS2OVQ>
Sf9 M3v3O2tqdmG|ZTDBd5NigQ>? NI[weYwyKGh? M3rnN2ROW09? NF;pd3lKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIEhf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= M1fTbFE5PzV2NkW0
Sf9 MVHLbY5ie2ViQYPzZZk> MknhNUBp NWHpbHRtTE2VTx?= NH23bpRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHHsdIhiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhi NFrBb2gyQDd3NE[1OC=>
MDA-MB-361 MWHGeY5kfGmxbjDBd5NigQ>? NILaU2IzKGh? NITmOHBFVVOR NU[1W5R3UW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkig{txO NH;iUXoyQDd3NE[1OC=>
PC3 M3jT[WZ2dmO2aX;uJGF{e2G7 MYmyJIg> Mm[5SG1UVw>? M3fuOmlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gVHRGVi2wdXzsJIh2dWGwIGDDN{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yM{eg{txO NHruSosyQDd3NE[1OC=>
U87MG MoLOSpVv[3Srb36gRZN{[Xl? NYTjNpd6OiCq NInMU5dFVVOR NGroenRKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDVPFdOTyClZXzsd{B4cXSqIFnDOVAhd2ZiMD6wOFYh|ryP M{\JdVE5PzV2NkW0
MDA-MB-361 NFf3bVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv1blU6PiCq NVXlPFIyTE2VTx?= MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= MmnyNVg4PTR4NUS=
A2780 NVjhS3JDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXDfJc6PiCq MX3EUXNQ MoHXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDMke4NEBk\WyuczD3bZRpKFCLS{PDRUBidmRiUGTFUkBufXSjdHnvckB4cXSqIFnDOVAhd2ZiMD6xOEDPxE1? MY[xPFc2PDZ3NB?=
PC3 M{TFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUC5OkBp Ml;jSG1UVw>? NILrUFZKSzVyPUCuNlgh|ryP M4HYT|E5PzV2NkW0
U87MG NVTSWoJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofyPVYhcA>? NVfIW2g1TE2VTx?= MlvuTWM2OD1yLkm1JO69VQ>? NUPWVYZMOTh5NUS2OVQ>
Sf9 NV7mZpZyU2mwYYPlJGF{e2G7 MojIN|AhdWmw MYLEUXNQ MULJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiYX3veY51KG:oIFHUVEBkd26|dX3l[EB4cXSqIFnDOVAhd2ZiMD6wOFIh|ryP NUPvSmVpOjJ3NEizOFI>
RAW 264.7 NU\tVXBTU2mwYYPlJGF{e2G7 NVLiTZpYQTBibXnu MVLEUXNQ Mof3TY5pcWKrdHnvckBw\iCqdX3hckBRUTONZ3HtcYEh\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSUuWIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4zQThizszN NXixfm57OjJ3NEizOFI>
Sf9 M2TQRWtqdmG|ZTDBd5NigQ>? MmizNUBp NE\pPHlKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[mW2YTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU1[5JINmdGy|IIfpeIghUUN3MDDv[kAxNjBzNzFOwG0> NXvBSGRJOjN3NEC2OFU>
Sf9 M3;HNWtqdmG|ZTDBd5NigQ>? NFLEWYsyKGh? M4\yXWlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tl\Wy2YTDlfJBz\XO|ZXS= M{HobVI{PTRyNkS1
Sf9 MoTHT4lv[XOnIFHzd4F6 NH7DdYcyKGh? MkXHTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4didW2jIHX4dJJme3OnZB?= MWqyN|U1ODZ2NR?=
Sf9 MoLQT4lv[XOnIFHzd4F6 MXmxJIg> MVHJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPLZYxxcGFiZYjwdoV{e2Wm NVrLdmN6OjN3NEC2OFU>
SKOV3 MWTLbY5ie2ViQYPzZZk> NVj0T4V5OSEQvF2= Mn7rNUBp M1XiVWROW09? M3jQOGlvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25? NGnISGkzOzN4MEO0PC=>
MCF7 NIXHR2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljtNUDPxE1? M3HtZlk3KGh? NXjwWndXTE2VTx?= NIn2[lBIUTVyPUCuNFcxOiEQvF2= NFfkWVQzOzN4MEO0PC=>
SKOV3 NGfPdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkG4NUDPxE1? MX:5OkBp NFHlUmhFVVOR NEPWNYNIUTVyPUCuNVQ4PiEQvF2= NE\rWZgzOzN4MEO0PC=>
PC3 NXfjOXB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\R[VczKGh? MUXEUXNQ NEDERXVKSzVyPUCuNlgh|ryP NXTQfFZlOjF7OEG3NVQ>
MCF7.1 NXfwdWRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[3NkBp NGTjdXFFVVOR MmmzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BJTVJ{IHflcoUhf2m2aDDJR|UxKG:oIECuNlgh|ryP NVy4SYZiOjF7OEG3NVQ>
MCF7-neo/Her2 NUjXfpAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fMSVczKGh? NFjOeGZFVVOR M4jkUGlEPTB;MD6yPUDPxE1? NFrVOFgzOzZ4MkmwNy=>
MCF7-neo/Her2 MlvMT4lv[XOnIFHzd4F6 NGHXWXhKdmirYnn0bY9vKG:oIGDJN2tidHCqYTDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbjDheEBUPDd|IIfpeIghUUN3MDDv[kAxNjByNzFOwG0> M125UFI{PjZ{OUCz
PC3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLFO|IhcA>? M{i5T2ROW09? MV\FR|UxRTBwM{Sg{txO MVSyNVk5PTZ|OR?=
MCF7.1 M2nr[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPXbFF1PzJiaB?= MXjEUXNQ NYLRdG1pSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCSSUPLZYxxcGFibYX0ZY51KHerdHigSWM2OCCxZjCwMlM6KM7:TR?= M{HsclIyQTh3NkO5
PC3 NFq4[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVi3NkBp NE\j[JhFVVOR MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCmZX\pZ4lmdnRiaX6gVHRGViC5aYToJGlEPTBib3[gNE4{QSEQvF2= NXK5NG1LOjByNUC2Olk>
MCF7.1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2noW|czKGh? NHfSOJFFVVOR M4L4NWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFnDOVAhd2ZiMD6zOEDPxE1? NFTldm4zODB3ME[2PS=>
MCF7.1 MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHHO|IhcA>? M1XvOGVEPTB;MD63NkDPxE1? NX3TVYdVOjB|NE[2OVY>
NCI-H1975 M3TwOmN6fG:2b4jpZ{BCe3OjeR?= NF3JdVc4OiCq M1\Vb2lEPTB;MD6yO{DPxE1? MWiyN|A2QTV2NR?=
H460 NYLqNGpqS3m2b4TvfIlkKEG|c3H5 MVW3NkBp M1\XZmlEPTB;MD64O{DPxE1? NHz0[oQzOzB3OUW0OS=>
HT-29 MXXDfZRwfG:6aXOgRZN{[Xl? NHvC[Gk4OiCq MonVTWM2OD1yLk[2JO69VQ>? MkKxNlMxPTl3NEW=
HepG2 MYnDfZRwfG:6aXOgRZN{[Xl? NVHnTZI6PzJiaB?= MVLJR|UxRTFizszN M{LEOlI{ODV7NUS1
SGC7901 MmTIR5l1d3SxeHnjJGF{e2G7 NUXDZmZiPzJiaB?= MX;JR|UxRTFwODFOwG0> MU[yN|A2QTV2NR?=
NCI-H226 NFTrflhEgXSxdH;4bYMhSXO|YYm= MkC4O|IhcA>? MV\JR|UxRTJwOTFOwG0> NEHUN3QzOzB3OUW0OS=>
A549 MYLDfZRwfG:6aXOgRZN{[Xl? M4WxOFczKGh? MlvTTWM2OD14Lkmg{txO MonaNlMxPTl3NEW=
U87MG M2DqSWN6fG:2b4jpZ{BCe3OjeR?= NUT0W4pOPzJiaB?= NEXlWFJKSzVyPUeuO|ch|ryP M1\DU|I{ODV7NUS1
HBC4 NFS5bGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXt[2lWdG:pR1m1NF0uPi5yMzDN NUTGbnlSOjJ|M{[yOFY>
BSY1 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;WZ3ptd2eJSUWwQU03NjlyIF2= NVu2fGl4OjJ|M{[yOFY>
HBC5 M4DJUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\IcI9oT0l3ME2tOk43OCCP MUWyNlM{PjJ2Nh?=
MCF7 Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDsc4dIUTVyPT23MlM{KE1? NV;UZZAxOjJ|M{[yOFY>
MDA-MB-231 NYLmVo9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13Lboxw\0eLNUC9MVUvPDZiTR?= M4nQOlIzOzN4MkS2
U251 MojsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnsc4dIUTVyPT21MlUxKE1? MnTLNlI{OzZ{NE[=
SF268 NHviV|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ruVYxw\0eLNUC9MVUvOzliTR?= MlnhNlI{OzZ{NE[=
SF295 NWfYdpNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\sc4dIUTVyPT22MlM4KE1? NETGe4kzOjN|NkK0Oi=>
SF539 NFXYbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLybnNIdG:pR1m1NF0uPi53MDDN MWqyNlM{PjJ2Nh?=
SNB75 M1nSbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIWyWINtd2eJSUWwQU04NjFyIF2= MYqyNlM{PjJ2Nh?=
SNB78 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\qcI9oT0l3ME2tOk42OiCP NEDid3QzOjN|NkK0Oi=>
HCC2998 MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HoW4xw\0eLNUC9MVYvOjliTR?= M2jy[FIzOzN4MkS2
KM12 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljJcI9oT0l3ME2tOU44PiCP NI\C[WMzOjN|NkK0Oi=>
HT-29 NX\rT5ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPTcI9oT0l3ME2tOk4{OCCP MlHMNlI{OzZ{NE[=
HCT15 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3COXhtd2eJSUWwQU03NjF{IF2= MYKyNlM{PjJ2Nh?=
HCT116 M2XNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLIWVdtd2eJSUWwQU02Njh5IF2= NXS3WWNpOjJ|M{[yOFY>
NCI-H23 NX7JZWdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\sc4dIUTVyPT21Mlc{KE1? NVv3WmdWOjJ|M{[yOFY>
NCI-H226 M4K3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PKc4xw\0eLNUC9MVYvOjFiTR?= M3rqRVIzOzN4MkS2
NCI-H522 MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTWVVg5dG:pR1m1NF0uPi53ODDN NX;M[3F7OjJ|M{[yOFY>
NCI-H483 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\5cI9oT0l3ME2tOk42PiCP M3LISVIzOzN4MkS2
A549 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX2OIVrdG:pR1m1NF0uPi5zNTDN MmnZNlI{OzZ{NE[=
DMS273 M13RVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjCdVdtd2eJSUWwQU03NjR|IF2= MYiyNlM{PjJ2Nh?=
DMS114 NH:ySGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\TVVRIdG:pR1m1NF0uPS57MjDN M2LIdFIzOzN4MkS2
LOXIMVI NIn3W41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XwTYxw\0eLNUC9MVYvOjliTR?= NGPkcXMzOjN|NkK0Oi=>
OVCAR3 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHTO4Vtd2eJSUWwQU03NjdzIF2= M1PvTVIzOzN4MkS2
OVCAR4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;CcI9oT0l3ME2tOU44PiCP MVOyNlM{PjJ2Nh?=
OVCAR5 NV\pbpMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;sc4dIUTVyPT22MlI3KE1? MmLHNlI{OzZ{NE[=
OVCAR8 MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvBbHptd2eJSUWwQU02Njd|IF2= Mo\CNlI{OzZ{NE[=
SKOV3 NGjTPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7QfXZYdG:pR1m1NF0uPi53MjDN NH;CdnkzOjN|NkK0Oi=>
RXF631L MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHGcI9oT0l3ME2tOk45QCCP MXyyNlM{PjJ2Nh?=
ACHN NUCySXBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLZdXpJdG:pR1m1NF0uPi5yNzDN M1zOc|IzOzN4MkS2
St-4 M{fIS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnzcI9oT0l3ME2tOU42PiCP NHnWcJczOjN|NkK0Oi=>
MKN1 M3TDdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrBcI9oT0l3ME2tO{4xQCCP NXfu[ZgxOjJ|M{[yOFY>
MKN7 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjsc4dIUTVyPT22MlUxKE1? NXTGeWpnOjJ|M{[yOFY>
MKN28 NH7vXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HEOYxw\0eLNUC9MVUvPTJiTR?= NFr2PY0zOjN|NkK0Oi=>
MKN45 NY[ycW1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfsc4dIUTVyPT22MlU2KE1? MWOyNlM{PjJ2Nh?=
MKN74 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLMcI9oT0l3ME2tOk4xOiCP MlnJNlI{OzZ{NE[=
DU145 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzl[4ptd2eJSUWwQU02Njh3IF2= MUCyNlM{PjJ2Nh?=
PC3 MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfsc4dIUTVyPT22MlY3KE1? NI[3N3YzOjN|NkK0Oi=>
ES5 MojOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTVyLkKxJI5O M4Xob3NCVkeHUh?=
HH Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rtZmlEPTB;MUGxMlA5KG6P MV3TRW5ITVJ?
MHH-PREB-1 M3Xxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTFzND6zJI5O M4m1NnNCVkeHUh?=
NCI-H1770 NXPUem5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT5TWM2OD1zMkOuPFYhdk1? MVLTRW5ITVJ?
HuO9 Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnoTWM2OD1{ME[uNFIhdk1? NHLHXIhUSU6JRWK=
HAL-01 NWK2ZnB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HGV2lEPTB;MkC2Mlc{KG6P MmDJV2FPT0WU
NOS-1 Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\tcZl1UUN3ME2yNVEvQDJibl2= NYruZXpGW0GQR1XS
HGC-27 NW[3dHBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LHO2lEPTB;MkGyMlU4KG6P Ml\vV2FPT0WU
NB69 MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTSTWM2OD1{NEWuNlchdk1? NUfvTnRFW0GQR1XS
RS4-11 M4Tsb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzXOHVKSzVyPUK2NU44PiCwTR?= M4C2enNCVkeHUh?=
DOK MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n4VGlEPTB;M{CxMlchdk1? NWHiVXA1W0GQR1XS
LB2241-RCC Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTNyMz64OEBvVQ>? MoPJV2FPT0WU
NCI-H1623 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nGTmlEPTB;M{C0MlA5KG6P NVPvO5FRW0GQR1XS
YH-13 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfqUGhKSzVyPUOwOE4{OiCwTR?= MmDPV2FPT0WU
BPH-1 NGjKPVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjTVmVOUUN3ME2zNVQhdk1? NGXicJFUSU6JRWK=
AN3-CA MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP3N4NKSzVyPUO0NE4{PyCwTR?= MXPTRW5ITVJ?
ES7 NI\lSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TobGlEPTB;M{SxMlk6KG6P MW\TRW5ITVJ?
MDA-MB-175-VII M1r6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SyfWlEPTB;M{WyMlkzKG6P NYTwR3BoW0GQR1XS
GAMG MkGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\iTWM2OD1|N{CuPFUhdk1? MYLTRW5ITVJ?
CHL-1 NI\xbIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLJTWM2OD1|N{iuOlUhdk1? NXPHdXh2W0GQR1XS
NB7 M1XpWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfDNHVKSzVyPUO4PU45OyCwTR?= NIfkT|ZUSU6JRWK=
MFE-280 M1nGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTRzOD6yJI5O NEXPOnNUSU6JRWK=
HL-60 M{n4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnPdYs4UUN3ME20NlUvPzVibl2= NVrFOnJVW0GQR1XS
GCIY NYHqdoJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HMTGlEPTB;NEOzMlghdk1? NYH6[nBuW0GQR1XS
MDA-MB-361 M{PGXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrjeVRtUUN3ME20N|kvOTNibl2= Mn;oV2FPT0WU
LXF-289 MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvWTWM2OD12NEiuNlchdk1? M{SwdHNCVkeHUh?=
NBsusSR MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVm4T4VxUUN3ME20PFgvQDVibl2= M1\ycnNCVkeHUh?=
KU-19-19 M4XieGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjjTWpKSzVyPUWxOk4xPyCwTR?= MUPTRW5ITVJ?
A204 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTV{Mj6zN{BvVQ>? NWDmboVTW0GQR1XS
LB1047-RCC NY\NcXVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTV{Mj65N{BvVQ>? M1n4XnNCVkeHUh?=
COLO-684 NEPUTZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\NTWM2OD13MkOuNVEhdk1? MWTTRW5ITVJ?
PA-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Dx[2lEPTB;NUOyMlQyKG6P NFfycFRUSU6JRWK=
MG-63 M3jnWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTYVIFuUUN3ME21OFEvOTFibl2= NGjkNIVUSU6JRWK=
BHT-101 NE\LcFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfJTXFKSzVyPUW0OE46PCCwTR?= NVzSOodZW0GQR1XS
NKM-1 NFHWXW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPMZ5pKSzVyPUW5N{4xQSCwTR?= NFvLd3RUSU6JRWK=
T47D MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PESmlEPTB;NUm3MlU3KG6P NYnZU2I1W0GQR1XS
MOLT-4 NYX5UHdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{KwUWlEPTB;NkKzMlYzKG6P NVvH[W16W0GQR1XS
IGROV-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmm2TWM2OD14M{SuN|Ehdk1? MXXTRW5ITVJ?
ES4 NXPsRm9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXKd3hDUUN3ME22N|kvPTRibl2= NF;tVJhUSU6JRWK=
HuO-3N1 M3jocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL1R3VRUUN3ME22OFIvOzhibl2= MUnTRW5ITVJ?
NEC8 NIrzeJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHlOlFKSzVyPU[1N{42PyCwTR?= MkfJV2FPT0WU
HO-1-N-1 NFiyb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH3TWM2OD14NUmuNVchdk1? NFTNeFVUSU6JRWK=
EPCL-272H NILBdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTZ6Nz6yNUBvVQ>? Mlq3V2FPT0WU
D-263MG NImyVoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPUTWM2OD15MUiuNUBvVQ>? NV;ybXg2W0GQR1XS
MV-4-11 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTd{ND6zNUBvVQ>? MUfTRW5ITVJ?
SK-NEP-1 NWnO[mRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTd{NT65OEBvVQ>? M124cXNCVkeHUh?=
SW872 NIPFVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3BXlVPUUN3ME23NlcvQDlibl2= NFLHdIpUSU6JRWK=
P30-OHK MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rHOmlEPTB;N{OwMlcyKG6P NEPJbG9USU6JRWK=
OMC-1 MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInoXXhKSzVyPUe1NU4xQSCwTR?= MnjJV2FPT0WU
LoVo NEDFbG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH1PVFvUUN3ME23O|cvQSCwTR?= NIrWbHlUSU6JRWK=
LNCaP-Clone-FGC NWXPcYVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HtZmlEPTB;N{m2MlM1KG6P MlLpV2FPT0WU
L-363 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfzSVdKSzVyPUe5PE41OiCwTR?= MUfTRW5ITVJ?
ES8 NXXwWG14T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DRb2lEPTB;OEGwMlUzKG6P NWi1Z|lYW0GQR1XS
697 NVvmW|JmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTh|MT61OUBvVQ>? MVzTRW5ITVJ?
HSC-3 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljNTWM2OD16M{muOVQhdk1? MX7TRW5ITVJ?
H4 NEnmPYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonoTWM2OD16NUCuPFUhdk1? M1HHW3NCVkeHUh?=
QIMR-WIL MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK0bWNKSzVyPUi2OU4zKG6P MU\TRW5ITVJ?
OAW-42 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S5PWlEPTB;OEeyMlE6KG6P NFvL[5JUSU6JRWK=
MCF7 NWPrRXFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L3eWlEPTB;OEm4MlU6KG6P NVno[4NJW0GQR1XS
SCC-25 NWHISYQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC5PFA3UUN3ME25NVQvOTlibl2= Mn\DV2FPT0WU
NCI-H1563 MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWe2[GNrUUN3ME25NVUvQTlibl2= NWnxXod1W0GQR1XS
OVCAR-5 NWjvdVdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnW2TWM2OD17NECuNVchdk1? NH3JbmFUSU6JRWK=
HDLM-2 NYSxbJZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HRTmlEPTB;OUS5MlIhdk1? MUTTRW5ITVJ?
NB5 NFfOV|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTl3Nj62JI5O NHLQT5BUSU6JRWK=
NCI-H292 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnwTWM2OD17N{SuN|Ihdk1? NIm2VlhUSU6JRWK=
A101D NYDvdFdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\tTWM2OD17OUCuNVkhdk1? NH3PdlhUSU6JRWK=
NCI-H1648 NIjjSYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq0TWM2OD17OUiuOVEhdk1? M1O0V3NCVkeHUh?=
EKVX NHHmWodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrNXlVKSzVyPUGuNFEzQSEQvF2= M33O[3NCVkeHUh?=
SW1710 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjnWmpKSzVyPUGuNFQzOzNizszN MV\TRW5ITVJ?
WM-115 M3TUZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITTRWRKSzVyPUGuNFY3PTZizszN NHS3eWpUSU6JRWK=
CAL-54 NVHIeFZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwMEewPFEh|ryP M4\IZXNCVkeHUh?=
TGBC24TKB NXW2UmV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIiw[IZKSzVyPUGuNFgxPDVizszN NWn1WINzW0GQR1XS
NCI-H520 M3vOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjHN5RKSzVyPUGuNFg6PjdizszN M{X5WXNCVkeHUh?=
D-423MG Ml3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFwMEm5OlIh|ryP M33mbXNCVkeHUh?=
BFTC-905 NYTD[IdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonCTWM2OD1zLkGzOFQ6KM7:TR?= NVvhR4pKW0GQR1XS
HT MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HzOmlEPTB;MT6xN|Q4QCEQvF2= MXHTRW5ITVJ?
CTB-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jKSmlEPTB;MT6xOFI6OyEQvF2= M1y4O3NCVkeHUh?=
Hs-578-T NEjBbWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7V[3RKSzVyPUGuNVk2PjVizszN NGSyOHpUSU6JRWK=
HuH-7 MmXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPkO3duUUN3ME2xMlIxQTR7IN88US=> M{\3VnNCVkeHUh?=
LB996-RCC NITLOWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPCR4hKSzVyPUGuNlIyPzdizszN MVnTRW5ITVJ?
KYSE-270 NWPtb5pkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jjVWlEPTB;MT6yPVc{PCEQvF2= M2LLeXNCVkeHUh?=
A4-Fuk MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFwMkm5PVMh|ryP MknqV2FPT0WU
A498 M3H1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXqTWM2OD1zLkOwOFc1KM7:TR?= M3H3[XNCVkeHUh?=
SK-MEL-1 M1Phc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFwM{C2O|kh|ryP MXrTRW5ITVJ?
AU565 NIi4dndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTFwM{G4OlMh|ryP NF;yW4VUSU6JRWK=
Saos-2 M4f0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G3e2lEPTB;MT6zN|IxPSEQvF2= M3TkbnNCVkeHUh?=
A549 M3XmZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYriOoRuUUN3ME2xMlM6QTdizszN M1rZR3NCVkeHUh?=
BFTC-909 NETzVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjLTWM2OD1zLkSzN|A2KM7:TR?= NHLoToNUSU6JRWK=
MDA-MB-415 MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PaVWlEPTB;MT60PFY6OiEQvF2= M3m4WnNCVkeHUh?=
639-V NYr6cZI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPxXmxbUUN3ME2xMlUxOjR3IN88US=> NID2T5hUSU6JRWK=
A704 M3rmTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPhV3FKSzVyPUGuOVA4QDVizszN NXLab3JjW0GQR1XS
PANC-03-27 M2T5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTFwNUG0NFgh|ryP NXLoR5UzW0GQR1XS
SK-MEL-28 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\jd4xKSzVyPUGuOVYxQDVizszN M3vTR3NCVkeHUh?=
Ramos-2G6-4C10 MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnXSIJ3UUN3ME2xMlYxPzR4IN88US=> M1zGbnNCVkeHUh?=
HuP-T4 NXTObZJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnpXFdHUUN3ME2xMlYxPzd6IN88US=> MnqxV2FPT0WU
VA-ES-BJ NX65bXVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwNkGyO{DPxE1? MVnTRW5ITVJ?
EFM-19 Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTFwNkG4NUDPxE1? M3\Cb3NCVkeHUh?=
G-401 MmLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK1XZliUUN3ME2xMlYzOTZ2IN88US=> NYnPSJZwW0GQR1XS
D-566MG NFjURXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r6U2lEPTB;MT62NlU{KM7:TR?= NXzHSHk1W0GQR1XS
JVM-3 M{XGW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPPTWM2OD1zLk[0PFc2KM7:TR?= Mom4V2FPT0WU
TK10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7tSlZMUUN3ME2xMlY4ODh|IN88US=> NUe0cpE2W0GQR1XS
BT-20 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHjTWM2OD1zLk[4PVAzKM7:TR?= NVTIWG1SW0GQR1XS
EGI-1 M2DwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH5TWM2OD1zLki0O|AyKM7:TR?= MmjQV2FPT0WU
EW-16 MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTFwOEWxPFIh|ryP MXLTRW5ITVJ?
NCI-H2228 NEnUU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTFwOEWyNFMh|ryP M2\YTnNCVkeHUh?=
BB49-HNC Mk\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDsTWM2OD1zLki4OlkzKM7:TR?= MXjTRW5ITVJ?
G-402 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlL1TWM2OD1zLki5O|k4KM7:TR?= NGDSeo1USU6JRWK=
NCI-H526 M4TzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXviTXZuUUN3ME2xMlkyOzlizszN MVjTRW5ITVJ?
ME-180 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfie5dKSzVyPUGuPVM1PzdizszN Mn;xV2FPT0WU
PFSK-1 NXvReXBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfOXJo1UUN3ME2xMlk1PDV6IN88US=> NVjRTFhuW0GQR1XS
TYK-nu Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHTTWM2OD1zLkm1PFI{KM7:TR?= NXnjOnhMW0GQR1XS
HOS M1jETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHPTWM2OD1zLkm3PVQ5KM7:TR?= MYPTRW5ITVJ?
T98G MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n2PGlEPTB;MT65PVAxPiEQvF2= NFzyWmFUSU6JRWK=
SK-MES-1 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTJwMEGzN|Ih|ryP Mo[zV2FPT0WU
SNB75 M4H5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\oXpVrUUN3ME2yMlAyPTRzIN88US=> MVvTRW5ITVJ?
LAMA-84 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLhSVJKSzVyPUKuNFI3QDlizszN NF7qbXhUSU6JRWK=
CAL-39 NHPJNHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHZTWM2OD1{LkCzNlgh|ryP M1z6UHNCVkeHUh?=
LOXIMVI NIqwTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELXNItKSzVyPUKuNFQxQDRizszN MkDOV2FPT0WU
NH-12 NHy2V|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjjTWM2OD1{LkC1OFI1KM7:TR?= NF\1Z3pUSU6JRWK=
NCI-H1048 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf0fGJKSzVyPUKuNVA2OiEQvF2= M3PKc3NCVkeHUh?=
KS-1 M3nxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwMUGwNFEh|ryP MXrTRW5ITVJ?
NCI-N87 M1;RWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPYTWM2OD1{LkGzN|g1KM7:TR?= NHjPS4JUSU6JRWK=
CHP-212 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJwMUi0OFIh|ryP MWrTRW5ITVJ?
HCC1419 M2\zcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTJwMkGxNVUh|ryP MYTTRW5ITVJ?
ES1 NH\WWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvmbnJKSzVyPUKuNlE{OjZizszN MVjTRW5ITVJ?
NCI-H2030 MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW2d|JKSzVyPUKuNlQyOjNizszN MYTTRW5ITVJ?
EW-22 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTiTWM2OD1{LkK1NFY4KM7:TR?= M2jnNXNCVkeHUh?=
A431 M1vYdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlyzTWM2OD1{LkK3N|U1KM7:TR?= MVTTRW5ITVJ?
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COLO-824 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJ3LkW1PVkh|ryP MU\TRW5ITVJ?
NCI-H1155 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ3LkW4OFch|ryP M2PaeHNCVkeHUh?=
NCI-H441 NWTQbJVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHOeoNKSzVyPUK1Mlc1PjVizszN M1X2bnNCVkeHUh?=
J-RT3-T3-5 M{PqVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfITWM2OD1{Nj6zNFI4KM7:TR?= NYPPTmFEW0GQR1XS
JEG-3 M3zLfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfmPFBnUUN3ME2yOk43QDB3IN88US=> MlPzV2FPT0WU
RKO NWjGeHkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTJ4Lke2N|Ih|ryP M1LqdnNCVkeHUh?=
CAL-85-1 M4DkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe5WZljUUN3ME2yO{4zOTF6IN88US=> Mn\4V2FPT0WU
CAL-120 M4S2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT1cYtKSzVyPUK3MlY6OTRizszN MlzwV2FPT0WU
NCI-H2452 NIq1UpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknrTWM2OD1{Nz63O|E3KM7:TR?= M{Xo[HNCVkeHUh?=
NCI-H1395 NH\PWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[zTWM2OD1{Nz63PFM{KM7:TR?= NX76W5FvW0GQR1XS
KYSE-450 MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJ5Lkm4OlIh|ryP NWG1Ung1W0GQR1XS
S-117 NWq0VHVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HFNGlEPTB;MkmuN|g2PyEQvF2= MmjQV2FPT0WU
SW13 NEXHfYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HrdmlEPTB;MkmuPFUyQSEQvF2= M4LpVnNCVkeHUh?=
ES3 NI\NU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L1WGlEPTB;M{CuN|c{OyEQvF2= M1XMOnNCVkeHUh?=
HCT-116 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;lN|hKSzVyPUOwMlU2PTRizszN MWjTRW5ITVJ?
NCI-H1693 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\ZRmlwUUN3ME2zNE42QTR{IN88US=> NFjiPFNUSU6JRWK=
VM-CUB-1 MoPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTNyLk[0NVMh|ryP MVTTRW5ITVJ?
NCI-H2170 M1S2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nBWmlEPTB;M{GuOVc5PCEQvF2= MYnTRW5ITVJ?
ALL-PO M3LMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHGXYVXUUN3ME2zNU45PDJ6IN88US=> M4rO[nNCVkeHUh?=
NCI-H661 NVrJZ3A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHkTWM2OD1|Mj6wOlI{KM7:TR?= MW\TRW5ITVJ?
NCI-H2347 NVTSNHpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnzTWFKSzVyPUOyMlQ5OzdizszN MljIV2FPT0WU
FTC-133 NX[0ZW45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTN{LkewOkDPxE1? NYHsT|RCW0GQR1XS
COLO-829 NWLr[JhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLQN3VKSzVyPUOzMlM1PjdizszN Mn\XV2FPT0WU
GOTO NVvOR|VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW1cndKSzVyPUOzMlUzPThizszN M1zYdXNCVkeHUh?=
YAPC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTN|LkixOVkh|ryP M{D3eXNCVkeHUh?=
LCLC-103H NUPibnBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC0SFBKSzVyPUO0MlE3OjRizszN M2TENHNCVkeHUh?=
SiHa NHLD[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHr[IR3UUN3ME2zOE4{QDF5IN88US=> M{\nUXNCVkeHUh?=
LK-2 MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLyTWM2OD1|ND61O|A5KM7:TR?= NF\RSY5USU6JRWK=
KP-N-YS NI\ENIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILuZmhKSzVyPUO0MlczODJizszN M4\RZnNCVkeHUh?=
NCI-SNU-1 NEnIWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDLdZZKSzVyPUO1MlE4QSEQvF2= NVrPZY8xW0GQR1XS
KNS-81-FD M1fEZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nwSWlEPTB;M{WuOlY{KM7:TR?= NH\xfIFUSU6JRWK=
SCC-9 M1HFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XaS2lEPTB;M{[uO|E1PiEQvF2= MkH4V2FPT0WU
SH-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTN4LkezJO69VQ>? NILEPJRUSU6JRWK=
HCC-1954 NHzRXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPYTWM2OD1|Nz6yO|I6KM7:TR?= MlnaV2FPT0WU
BALL-1 M334UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HuZWlEPTB;M{euOVMyPiEQvF2= M3S2cHNCVkeHUh?=
BE-13 NH:zd2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTN5LkewNVgh|ryP NVvNfZJMW0GQR1XS
COLO-678 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;IemdKSzVyPUO3Mlk1OzdizszN M135WXNCVkeHUh?=
SK-MEL-3 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu5elE2UUN3ME2zPE4zOzl5IN88US=> MlPlV2FPT0WU
OAW-28 M2HZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz0OHdTUUN3ME2zPE43OzlizszN NXHWbIdKW0GQR1XS
CAMA-1 M1yzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK0[Y1qUUN3ME2zPE46PjlzIN88US=> M3LCS3NCVkeHUh?=
C2BBe1 NHHwTmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjLSnVKSzVyPUO5MlgyQCEQvF2= MkLIV2FPT0WU
A3-KAW NXrhUXlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnKTWM2OD12MD6zOlYyKM7:TR?= MW\TRW5ITVJ?
SK-MEL-24 Mnm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXr[VBvUUN3ME20NE42QTNzIN88US=> MmrCV2FPT0WU
KYSE-140 M2G5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTRyLkexOlUh|ryP M{PIWnNCVkeHUh?=
MOLT-16 NYLlUY5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr2UWRKSzVyPUSxMlE2OzZizszN NF35Ro5USU6JRWK=
CFPAC-1 NEP2cpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfzTGdKSzVyPUSyMlUzOTFizszN MVnTRW5ITVJ?
NB14 NEDVSZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[wXVhsUUN3ME20Nk44ODJ5IN88US=> NVfqNYNnW0GQR1XS
COLO-792 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjrZlVKSzVyPUSyMlg6PjFizszN NXXVTJd{W0GQR1XS
RH-1 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;ifmlEPTB;NEOuOFg{PiEQvF2= NILZboxUSU6JRWK=
NCI-H522 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHTd411UUN3ME20OE4{PTZ6IN88US=> M4TP[3NCVkeHUh?=
Ca-Ski NInGXHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjhTWM2OD12ND64NVE1KM7:TR?= M4XIW3NCVkeHUh?=
KGN M2LBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LOfWlEPTB;NEiuN|A3OyEQvF2= NH3LT5RUSU6JRWK=
UACC-62 MmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnlWphqUUN3ME20PE41ODd{IN88US=> MUHTRW5ITVJ?
NCI-H358 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvZT25ZUUN3ME20PU4{ODF6IN88US=> MkGzV2FPT0WU
LS-411N M3nKSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fQc2lEPTB;NEmuN|EyQCEQvF2= M{noW3NCVkeHUh?=
IST-MES1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\2TWM2OD12OT61OlI2KM7:TR?= NFfz[Y1USU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]
臨床試験 A Phase I study of GDC-0941 in patients with locally advanced or metastatic solid tumors, Non-Hodgkin's lymphoma, or multiple myeloma (MM) (expansion stage only) for which standard therapy either does not exist or has proven ineffective or intolerable is
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Scintillation proximity assay Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.

細胞アッセイ: [2]

細胞株 SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 48 and 72 hours
実験の流れ Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.

動物実験: [2]

動物モデル NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
製剤 Dissolved in 10% DMSO, 5% Tween 20, 85% water
投薬量 ~150 mg/kg/day
投与方法 Oral gavage

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Pictilisib (GDC-0941) SDF
分子量 513.64
化学式

C23H27N7O3S2

CAS No. 957054-30-7
保管 2年-20℃
6月-80℃in solvent
別名 RG7321
溶解度 (25°C) * In vitro DMSO 44 mg/mL (85.66 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine

文献中の引用 (57)

技術サポート&よくある質問(FAQ)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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