Pictilisib (GDC-0941) 化学構造
分子量: 513.64

高品質保証

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Quality Control & MSDS

製品説明

  • Compare PI3K Inhibitors
    PI3K製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法
  • Pictilisib (GDC-0941)のメカニズム

製品の説明

生物活性

製品説明 Pictilisib (GDC-0941)は、PI3Kα、PI3Kβ、PI3KδとPI3Kγの強力な阻害剤で、IC50 がそれぞれ 3 nM、 33 nM、 3 nM、75 nMです。
ターゲット PI3Kα PI3Kβ PI3Kδ PI3Kγ
IC50 3 nM 33 nM 3 nM 75 nM [1]
In vitro試験 GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
Sf9 NETLZo9McW6jc3WgRZN{[Xl? M3r0W|EhcA>? NGDVeFhFVVOR NYHsOmFFUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDk[Yx1[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN NX30b45uOTh5NUS2OVQ>
Sf9 NUXFV3pDU2mwYYPlJGF{e2G7 NWrtdnh{OSCq M2fuOmROW09? MVXJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgTFExPDdvUjDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> NWmwbmVrOTh5NUS2OVQ>
Sf9 NIP5bIRMcW6jc3WgRZN{[Xl? MX[xJIg> M4XwNmROW09? MmrLTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> NEf3[mUyQDd3NE[1OC=>
Sf9 MWTLbY5ie2ViQYPzZZk> M{LCNVEhcA>? Mn;VSG1UVw>? MkX4TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCzN{DPxE1? MWKxPFc2PDZ3NB?=
Sf9 MnrOT4lv[XOnIFHzd4F6 M{\qb|EhcA>? MX7EUXNQ M4i1cGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYXzwbIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIE> MXexPFc2PDZ3NB?=
MDA-MB-361 M{TuNGZ2dmO2aX;uJGF{e2G7 NF:wc4UzKGh? M1r4e2ROW09? MmXaTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4xOjhizszN MYmxPFc2PDZ3NB?=
PC3 M1XXfWZ2dmO2aX;uJGF{e2G7 M3:xR|IhcA>? MXPEUXNQ NYizSYpXUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gVGM{KGOnbHzzJJdqfGhiSVO1NEBw\iByLkCzO{DPxE1? NGrldJoyQDd3NE[1OC=>
U87MG M1\USWZ2dmO2aX;uJGF{e2G7 MX[yJIg> NYrqV4M1TE2VTx?= MnrzTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDQWGVPNW63bHygbJVu[W5iVUi3UWch[2WubIOge4l1cCCLQ{WwJI9nKDBwMES2JO69VQ>? NVXsRXk4OTh5NUS2OVQ>
MDA-MB-361 MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XNV|k3KGh? NXXjUWVpTE2VTx?= M{[4cGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTN4MTDj[YxteyC5aYToJHBKUzOFQTDFOVQ2NUtibYX0ZZRqd25id3n0bEBKSzVyIH;mJFAvPzJizszN MlrCNVg4PTR4NUS=
A2780 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXNXlU6PiCq MV7EUXNQ MkH2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDMke4NEBk\WyuczD3bZRpKFCLS{PDRUBidmRiUGTFUkBufXSjdHnvckB4cXSqIFnDOVAhd2ZiMD6xOEDPxE1? MYqxPFc2PDZ3NB?=
PC3 NEnBXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HUXVk3KGh? NXrOU|VTTE2VTx?= NYDZb2M4UUN3ME2wMlI5KM7:TR?= NIC0TpYyQDd3NE[1OC=>
U87MG MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS2OJA6PiCq MofxSG1UVw>? MYXJR|UxRTBwOUWg{txO MV6xPFc2PDZ3NB?=
Sf9 NH3SS3FMcW6jc3WgRZN{[Xl? NYSycoZyOzBibXnu NGDwb|NFVVOR M2fYcGlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDhcY92dnRib3[gRXRRKGOxboP1cYVlKHerdHigTWM2OCCxZjCwMlA1OiEQvF2= M{jHbVIzPTR6M{Sy
RAW 264.7 MoX0T4lv[XOnIFHzd4F6 MXS5NEBucW5? NVy5WmxsTE2VTx?= MULJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCU1RicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlI6QCEQvF2= NUniXmd[OjJ3NEizOFI>
Sf9 MYrLbY5ie2ViQYPzZZk> MVmxJIg> NWr2flR7UW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2KndHGg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPGPUBk\WyuczD3bZRpKEmFNUCgc4YhOC5yMUeg{txO NH\4fmIzOzV2ME[0OS=>
Sf9 NWHmVHF2U2mwYYPlJGF{e2G7 NIqzSXoyKGh? NFnOZVJKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM\GWudHGg[ZhxemW|c3Xk NInXcYIzOzV2ME[0OS=>
Sf9 MVPLbY5ie2ViQYPzZZk> NY\NTpNSOSCq NXvHXJJjUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2ejbX3hJIV5eHKnc4Pl[C=> NXG2d5YxOjN3NEC2OFU>
Sf9 NXPURXFEU2mwYYPlJGF{e2G7 MUmxJIg> MkPSTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4FteGijIHX4dJJme3OnZB?= NGTvUm4zOzV2ME[0OS=>
SKOV3 NFrFdG9McW6jc3WgRZN{[Xl? NVvLO|d[OSEQvF2= NV2yT|VpOSCq NWnyNnNuTE2VTx?= NITlZ5ZKdmirYnn0bY9vKG:oIGDJN2tidHCqYTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:w MofXNlM{PjB|NEi=
MCF7 NYGxSpNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jPTVEh|ryP MWm5OkBp NGK4RpRFVVOR NGHwdndIUTVyPUCuNFcxOiEQvF2= NVvZco55OjN|NkCzOFg>
SKOV3 MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYSxJO69VQ>? MUO5OkBp NUnQ[4VZTE2VTx?= Ml:3S2k2OD1yLkG0O|Yh|ryP NWXDU4lxOjN|NkCzOFg>
PC3 M2TCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fs[VczKGh? NFKydlhFVVOR M3L3cGlEPTB;MD6yPEDPxE1? NXyxZnJTOjF7OEG3NVQ>
MCF7.1 M4Lwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;ueVY4OiCq NGf4OmNFVVOR NWHHc|M1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCKRWKyJIdmdmVid3n0bEBKSzVyIH;mJFAvOjhizszN NXK4fWh[OjF7OEG3NVQ>
MCF7-neo/Her2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjkeY84OiCq M3v6NmROW09? NGCwXlBKSzVyPUCuNlkh|ryP M{fyVFI{PjZ{OUCz
MCF7-neo/Her2 M1npR2tqdmG|ZTDBd5NigQ>? M{jzOWlvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIHH0JHM1PzNid3n0bEBKSzVyIH;mJFAvODB5IN88US=> NUfqe25[OjN4NkK5NFM>
PC3 NGHoTphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInQbGY4OiCq NUni[3BWTE2VTx?= NV7t[ZlpTUN3ME2wMlM1KM7:TR?= NWX6XpdGOjF7OEW2N|k>
MCF7.1 NUDLelRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X0NFczKGh? NXy4UY1DTE2VTx?= Mn3GRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiRVO1NEBw\iByLkO5JO69VQ>? M361SlIyQTh3NkO5
PC3 MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjUO|IhcA>? Mli5SG1UVw>? MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCmZX\pZ4lmdnRiaX6gVHRGViC5aYToJGlEPTBib3[gNE4{QSEQvF2= NYXVWldFOjByNUC2Olk>
MCF7.1 M3TDbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr3fWw4OiCq MkfCSG1UVw>? MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCLQ{WwJI9nKDBwM{Sg{txO MXWyNFA2ODZ4OR?=
MCF7.1 M1\2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{KyZ|czKGh? NXjCfW82TUN3ME2wMlczKM7:TR?= M{CxN|IxOzR4NkW2
NCI-H1975 MoP0R5l1d3SxeHnjJGF{e2G7 NFKwOnc4OiCq M3r3PGlEPTB;MD6yO{DPxE1? NVG5UJBCOjNyNUm1OFU>
H460 NY\jPI5sS3m2b4TvfIlkKEG|c3H5 MXi3NkBp NEfZTFhKSzVyPUCuPFch|ryP M3jPRlI{ODV7NUS1
HT-29 MoXWR5l1d3SxeHnjJGF{e2G7 NXjSTFltPzJiaB?= NYXrR24{UUN3ME2wMlY3KM7:TR?= M3ywbFI{ODV7NUS1
HepG2 Mn;4R5l1d3SxeHnjJGF{e2G7 MW[3NkBp M1zEdmlEPTB;MTFOwG0> M4L3c|I{ODV7NUS1
SGC7901 MorLR5l1d3SxeHnjJGF{e2G7 Mnq3O|IhcA>? M2SzeWlEPTB;MT64JO69VQ>? M4HCfFI{ODV7NUS1
NCI-H226 NY\0TG0zS3m2b4TvfIlkKEG|c3H5 MUG3NkBp NXu3bFc1UUN3ME2yMlkh|ryP MluyNlMxPTl3NEW=
A549 M4DrR2N6fG:2b4jpZ{BCe3OjeR?= MYO3NkBp M4XwdGlEPTB;Nj65JO69VQ>? Mnj3NlMxPTl3NEW=
U87MG MlT5R5l1d3SxeHnjJGF{e2G7 M2PG[VczKGh? MnG0TWM2OD15Lke3JO69VQ>? MYKyN|A2QTV2NR?=
HBC4 Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;rUJZtdG:pR1m1NF0uPi5yMzDN NF2wOZczOjN|NkK0Oi=>
BSY1 NGWx[WFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\sc4dIUTVyPT22MlkxKE1? MVeyNlM{PjJ2Nh?=
HBC5 NYi2bmh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrMcXFtd2eJSUWwQU03NjZyIF2= M3LVVVIzOzN4MkS2
MCF7 M4fvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnacI9oT0l3ME2tO{4{OyCP MojBNlI{OzZ{NE[=
MDA-MB-231 NEPScVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TGS4xw\0eLNUC9MVUvPDZiTR?= MX6yNlM{PjJ2Nh?=
U251 Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvYW4hTdG:pR1m1NF0uPS53MDDN M1G3c|IzOzN4MkS2
SF268 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTIcI9oT0l3ME2tOU4{QSCP MnzzNlI{OzZ{NE[=
SF295 M4qzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITRfmJtd2eJSUWwQU03NjN5IF2= MlTPNlI{OzZ{NE[=
SF539 NHTGUJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHRNHRtd2eJSUWwQU03NjVyIF2= NH3hUogzOjN|NkK0Oi=>
SNB75 M{TXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHsc4dIUTVyPT23MlExKE1? MX:yNlM{PjJ2Nh?=
SNB78 M2rUVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz5d2pUdG:pR1m1NF0uPi53MjDN MXqyNlM{PjJ2Nh?=
HCC2998 NXzMd3R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vqdIxw\0eLNUC9MVYvOjliTR?= NIjYem0zOjN|NkK0Oi=>
KM12 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m0cYxw\0eLNUC9MVUvPzZiTR?= NUjSe3pMOjJ|M{[yOFY>
HT-29 NEX1d3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7ocI9oT0l3ME2tOk4{OCCP NX6yNYxHOjJ|M{[yOFY>
HCT15 NVTXeFZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC2OmZtd2eJSUWwQU03NjF{IF2= NFu1VJgzOjN|NkK0Oi=>
HCT116 NFPEWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G5TIxw\0eLNUC9MVUvQDdiTR?= NUHWOWR5OjJ|M{[yOFY>
NCI-H23 NID2TZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHsc4dIUTVyPT21Mlc{KE1? NUOxXZlNOjJ|M{[yOFY>
NCI-H226 NHrWPY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjOcI9oT0l3ME2tOk4zOSCP NFjDbGozOjN|NkK0Oi=>
NCI-H522 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXjeVRtd2eJSUWwQU03NjV6IF2= MlyyNlI{OzZ{NE[=
NCI-H483 NVjxOXFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\DcI9oT0l3ME2tOk42PiCP NXPR[IdOOjJ|M{[yOFY>
A549 NHjFXHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULsc4dIUTVyPT22MlE2KE1? NXPX[o0zOjJ|M{[yOFY>
DMS273 NX;XSHZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrHTol{dG:pR1m1NF0uPi52MzDN NGf6VlkzOjN|NkK0Oi=>
DMS114 M3zxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[zRXNtd2eJSUWwQU02Njl{IF2= NFPPZmwzOjN|NkK0Oi=>
LOXIMVI NEfNc41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\5S4xw\0eLNUC9MVYvOjliTR?= NX63ZXRlOjJ|M{[yOFY>
OVCAR3 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXsc4dIUTVyPT22MlcyKE1? MYSyNlM{PjJ2Nh?=
OVCAR4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDsc4dIUTVyPT21Mlc3KE1? NX\UUI5uOjJ|M{[yOFY>
OVCAR5 NV:yRZNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TzSIxw\0eLNUC9MVYvOjZiTR?= MmfUNlI{OzZ{NE[=
OVCAR8 NW\wVJJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknvcI9oT0l3ME2tOU44OyCP MVuyNlM{PjJ2Nh?=
SKOV3 MkjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPucFZRdG:pR1m1NF0uPi53MjDN NX;IOndQOjJ|M{[yOFY>
RXF631L NHztbG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnsc4dIUTVyPT22Mlg5KE1? MVKyNlM{PjJ2Nh?=
ACHN MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\sc4dIUTVyPT22MlA4KE1? M1j0e|IzOzN4MkS2
St-4 NXrsZolET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfsc4dIUTVyPT21MlU3KE1? NETLemYzOjN|NkK0Oi=>
MKN1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXni[2VWdG:pR1m1NF0uPy5yODDN M{jSPFIzOzN4MkS2
MKN7 MorXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D0RYxw\0eLNUC9MVYvPTBiTR?= MWqyNlM{PjJ2Nh?=
MKN28 M3WyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInMVJRtd2eJSUWwQU02NjV{IF2= MV[yNlM{PjJ2Nh?=
MKN45 M1XsfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHldohtd2eJSUWwQU03NjV3IF2= MV:yNlM{PjJ2Nh?=
MKN74 NGr3RYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWC4U2sydG:pR1m1NF0uPi5yMjDN NHTDTJgzOjN|NkK0Oi=>
DU145 NEnGU|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkixcI9oT0l3ME2tOU45PSCP M2X0WlIzOzN4MkS2
PC3 M1LOVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojvcI9oT0l3ME2tOk43PiCP MUKyNlM{PjJ2Nh?=
ES5 MlnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYSzXVVRUUN3ME21NE4zOSCwTR?= M3rFU3NCVkeHUh?=
HH NV75enBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXFTWM2OD1zMUGuNFghdk1? M3rmbnNCVkeHUh?=
MHH-PREB-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTFzND6zJI5O NYWxXHc1W0GQR1XS
NCI-H1770 M4njNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoCzTWM2OD1zMkOuPFYhdk1? NFu4O|RUSU6JRWK=
HuO9 NX\4Oph{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3kNZJMUUN3ME2yNFYvODJibl2= NFPHWJNUSU6JRWK=
HAL-01 M4HtSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S3SmlEPTB;MkC2Mlc{KG6P MXfTRW5ITVJ?
NOS-1 M2nzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Lwc2lEPTB;MkGxMlgzKG6P NX72bI13W0GQR1XS
HGC-27 NYrqboRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJzMj61O{BvVQ>? MXTTRW5ITVJ?
NB69 NYXHTHViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\2T2lEPTB;MkS1MlI4KG6P MkDRV2FPT0WU
RS4-11 NX7lRWRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnpTWM2OD1{NkGuO|Yhdk1? M4jTV3NCVkeHUh?=
DOK MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y3fmlEPTB;M{CxMlchdk1? MXPTRW5ITVJ?
LB2241-RCC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfsTWM2OD1|MEOuPFQhdk1? MkLFV2FPT0WU
NCI-H1623 NWHYUY1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n1NWlEPTB;M{C0MlA5KG6P MUfTRW5ITVJ?
YH-13 NH;0WVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTNyND6zNkBvVQ>? NX7rcmwzW0GQR1XS
BPH-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTNzNDDuUS=> NVHQWodWW0GQR1XS
AN3-CA NUP4[YZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTN2MD6zO{BvVQ>? NYPvNlJnW0GQR1XS
ES7 MoHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLlPXhKSzVyPUO0NU46QSCwTR?= NGD6fXJUSU6JRWK=
MDA-MB-175-VII M3rTbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrlTWM2OD1|NUKuPVIhdk1? M33FOHNCVkeHUh?=
GAMG NFK2NGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonRTWM2OD1|N{CuPFUhdk1? MkOyV2FPT0WU
CHL-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTN5OD62OUBvVQ>? NFTkc|NUSU6JRWK=
NB7 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfaOlJKSzVyPUO4PU45OyCwTR?= MVXTRW5ITVJ?
MFE-280 MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHabWZrUUN3ME20NVgvOiCwTR?= MoXaV2FPT0WU
HL-60 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHlfXp[UUN3ME20NlUvPzVibl2= MVLTRW5ITVJ?
GCIY NYD1Z2ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjzNWRyUUN3ME20N|MvQCCwTR?= Ml;CV2FPT0WU
MDA-MB-361 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTR|OT6xN{BvVQ>? M4j4XXNCVkeHUh?=
LXF-289 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW2TWM2OD12NEiuNlchdk1? NITQXVlUSU6JRWK=
NBsusSR MkXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTR6OD64OUBvVQ>? NUfUb2g3W0GQR1XS
KU-19-19 NFjVUYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELlc2JKSzVyPUWxOk4xPyCwTR?= M1L5THNCVkeHUh?=
A204 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXPTWM2OD13MkKuN|Mhdk1? NWPx[m17W0GQR1XS
LB1047-RCC NFHBXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HSVmlEPTB;NUKyMlk{KG6P MoDLV2FPT0WU
COLO-684 NVOwO2VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTV{Mz6xNUBvVQ>? MkHQV2FPT0WU
PA-1 M2jMWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTV|Mj60NUBvVQ>? NUC1PHQ5W0GQR1XS
MG-63 NYTBdpV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\0OmlEPTB;NUSxMlEyKG6P M3Xs[HNCVkeHUh?=
BHT-101 NEDHWYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TCOGlEPTB;NUS0Mlk1KG6P NY\6c4FEW0GQR1XS
NKM-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTV7Mz6wPUBvVQ>? NGOyVmxUSU6JRWK=
T47D MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTV7Nz61OkBvVQ>? NWXYdnVuW0GQR1XS
MOLT-4 MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTZ{Mz62NkBvVQ>? NFvUWJBUSU6JRWK=
IGROV-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jJdmlEPTB;NkO0MlMyKG6P NEnSOIhUSU6JRWK=
ES4 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7HTWM2OD14M{muOVQhdk1? NVi0fo9UW0GQR1XS
HuO-3N1 NY\RW4tbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXxVZV4UUN3ME22OFIvOzhibl2= NWXYbJl4W0GQR1XS
NEC8 MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PiZmlEPTB;NkWzMlU4KG6P NXTqVZNzW0GQR1XS
HO-1-N-1 NWfBVpZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTZ3OT6xO{BvVQ>? MUfTRW5ITVJ?
EPCL-272H Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTZ6Nz6yNUBvVQ>? NYXwWGU3W0GQR1XS
D-263MG M3XpNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfubHVoUUN3ME23NVgvOSCwTR?= MX3TRW5ITVJ?
MV-4-11 NGHOXZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTd{ND6zNUBvVQ>? NVTDbpY{W0GQR1XS
SK-NEP-1 M{\ubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;3R2lEPTB;N{K1Mlk1KG6P MXLTRW5ITVJ?
SW872 NW\WbJF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm4[mprUUN3ME23NlcvQDlibl2= MUPTRW5ITVJ?
P30-OHK NXnXS25uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonzTWM2OD15M{CuO|Ehdk1? NIfjbFZUSU6JRWK=
OMC-1 NILSOpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzyTWM2OD15NUGuNFkhdk1? NYTDRYRHW0GQR1XS
LoVo MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj4RpBKSzVyPUe3O{46KG6P M{nRNXNCVkeHUh?=
LNCaP-Clone-FGC MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTd7Nj6zOEBvVQ>? NVXlNHJ5W0GQR1XS
L-363 MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M135ZWlEPTB;N{m4MlQzKG6P Mn3uV2FPT0WU
ES8 NFLFcoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTN[VBKSzVyPUixNE42OiCwTR?= M3\BRXNCVkeHUh?=
697 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTh|MT61OUBvVQ>? NFvEcGlUSU6JRWK=
HSC-3 NHjzZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7STWM2OD16M{muOVQhdk1? M13abnNCVkeHUh?=
H4 M1;sRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzoTWM2OD16NUCuPFUhdk1? M1TydHNCVkeHUh?=
QIMR-WIL NIn2U|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnSV3J[UUN3ME24OlUvOiCwTR?= MnzuV2FPT0WU
OAW-42 MlG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojLTWM2OD16N{KuNVkhdk1? NULpZmdlW0GQR1XS
MCF7 M{Xv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXXXoNNUUN3ME24PVgvPTlibl2= MlvDV2FPT0WU
SCC-25 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHIc453UUN3ME25NVQvOTlibl2= MnrYV2FPT0WU
NCI-H1563 NV23ZoFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXxNWZKSzVyPUmxOU46QSCwTR?= NXXLPGhJW0GQR1XS
OVCAR-5 NIXpbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv0TWM2OD17NECuNVchdk1? NGjIVlBUSU6JRWK=
HDLM-2 MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4q0V2lEPTB;OUS5MlIhdk1? MV3TRW5ITVJ?
NB5 M3fG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jk[WlEPTB;OUW2MlYhdk1? NV\oVJFzW0GQR1XS
NCI-H292 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTl5ND6zNkBvVQ>? MmjqV2FPT0WU
A101D MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTl7MD6xPUBvVQ>? MVLTRW5ITVJ?
NCI-H1648 NV;XVFN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33HeGlEPTB;OUm4MlUyKG6P MVTTRW5ITVJ?
EKVX NEfDUnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;TbYY{UUN3ME2xMlAyOjlizszN NFHOcVlUSU6JRWK=
SW1710 M2rzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLpTWM2OD1zLkC0NlM{KM7:TR?= MUTTRW5ITVJ?
WM-115 NV7HWGlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnYbWFIUUN3ME2xMlA3PjV4IN88US=> NWixOnV5W0GQR1XS
CAL-54 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFwMEewPFEh|ryP NGnHd2FUSU6JRWK=
TGBC24TKB MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf0OW1KSzVyPUGuNFgxPDVizszN MYrTRW5ITVJ?
NCI-H520 M3m1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Wx[mlEPTB;MT6wPFk3PyEQvF2= MXrTRW5ITVJ?
D-423MG MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\rTWM2OD1zLkC5PVYzKM7:TR?= NGDLW|dUSU6JRWK=
BFTC-905 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f3fWlEPTB;MT6xN|Q1QSEQvF2= M1r2NHNCVkeHUh?=
HT NYe1ToFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIW1bXpKSzVyPUGuNVM1PzhizszN NXjYWGwxW0GQR1XS
CTB-1 M3H1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFwMUSyPVMh|ryP NETTcnZUSU6JRWK=
Hs-578-T M3yx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn1Z5ZnUUN3ME2xMlE6PTZ3IN88US=> MlXXV2FPT0WU
HuH-7 NUDTZ3lsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm2UGdKSzVyPUGuNlA6PDlizszN MXXTRW5ITVJ?
LB996-RCC MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFwMkKxO|ch|ryP M{\TXnNCVkeHUh?=
KYSE-270 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DqOWlEPTB;MT6yPVc{PCEQvF2= MXXTRW5ITVJ?
A4-Fuk NWDIdpM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3tTWM2OD1zLkK5PVk{KM7:TR?= NXniUWx1W0GQR1XS
A498 NXTXNXhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i2dGlEPTB;MT6zNFQ4PCEQvF2= MV7TRW5ITVJ?
SK-MEL-1 M334fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlixTWM2OD1zLkOwOlc6KM7:TR?= M{fkdXNCVkeHUh?=
AU565 M{[1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37DNGlEPTB;MT6zNVg3OyEQvF2= NFvsc|FUSU6JRWK=
Saos-2 NF\1do1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz5cYxKSzVyPUGuN|MzODVizszN NHXT[ndUSU6JRWK=
A549 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFwM{m5O{DPxE1? NHHxUXNUSU6JRWK=
BFTC-909 MnzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTFwNEOzNFUh|ryP M3znVnNCVkeHUh?=
MDA-MB-415 NGS3OZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmr5TWM2OD1zLkS4OlkzKM7:TR?= M1m1ZnNCVkeHUh?=
639-V NHGzZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXYcnNnUUN3ME2xMlUxOjR3IN88US=> NHr5OHdUSU6JRWK=
A704 NVf1WJdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7xWGVKSzVyPUGuOVA4QDVizszN M1PqeHNCVkeHUh?=
PANC-03-27 NVr4VYR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzieo9RUUN3ME2xMlUyPDB6IN88US=> NFfvUVFUSU6JRWK=
SK-MEL-28 NUjxbVZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\3NlVKSzVyPUGuOVYxQDVizszN M2Tac3NCVkeHUh?=
Ramos-2G6-4C10 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvUdppKSzVyPUGuOlA4PDZizszN M{jwSXNCVkeHUh?=
HuP-T4 NHnibYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHETWM2OD1zLk[wO|c5KM7:TR?= Mm\kV2FPT0WU
VA-ES-BJ NVLhVGxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjQenQ5UUN3ME2xMlYyOjdizszN M3\Y[nNCVkeHUh?=
EFM-19 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTFwNkG4NUDPxE1? NEDzfGVUSU6JRWK=
G-401 M3rtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrMTWM2OD1zLk[yNVY1KM7:TR?= M4jEenNCVkeHUh?=
D-566MG NWWzd5dwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzLVHBKSzVyPUGuOlI2OyEQvF2= MlTiV2FPT0WU
JVM-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTITWM2OD1zLk[0PFc2KM7:TR?= NX7QUFdWW0GQR1XS
TK10 NV74fHVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXtVldKSzVyPUGuOlcxQDNizszN MWPTRW5ITVJ?
BT-20 M1HWSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPuTWM2OD1zLk[4PVAzKM7:TR?= M1LqOHNCVkeHUh?=
EGI-1 NIXUPWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\1UFZKSzVyPUGuPFQ4ODFizszN MXLTRW5ITVJ?
EW-16 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX71[2VjUUN3ME2xMlg2OTh{IN88US=> MYHTRW5ITVJ?
NCI-H2228 MkTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzLZ3UzUUN3ME2xMlg2OjB|IN88US=> NInzOmJUSU6JRWK=
BB49-HNC M{Xh[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrEXngzUUN3ME2xMlg5Pjl{IN88US=> MVTTRW5ITVJ?
G-402 NYS1UWlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TzdGlEPTB;MT64PVc6PyEQvF2= NECwNGdUSU6JRWK=
NCI-H526 MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf1UmZqUUN3ME2xMlkyOzlizszN M3X6OXNCVkeHUh?=
ME-180 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWzR4hKSzVyPUGuPVM1PzdizszN NVzqdHVqW0GQR1XS
PFSK-1 NIXmdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXIUYFKSzVyPUGuPVQ1PThizszN NFPndpFUSU6JRWK=
TYK-nu Mn\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPoTWM2OD1zLkm1PFI{KM7:TR?= MXTTRW5ITVJ?
HOS MnnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3mUFRKSzVyPUGuPVc6PDhizszN MU\TRW5ITVJ?
T98G NXvXfVV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHGTWM2OD1zLkm5NFA3KM7:TR?= NWG5W3JkW0GQR1XS
SK-MES-1 NGjWUXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO5ZVBEUUN3ME2yMlAyOzN{IN88US=> MkS0V2FPT0WU
SNB75 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j6c2lEPTB;Mj6wNVU1OSEQvF2= M4GycXNCVkeHUh?=
LAMA-84 NWW1elJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPNTWM2OD1{LkCyOlg6KM7:TR?= M4XWO3NCVkeHUh?=
CAL-39 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJwMEOyPEDPxE1? Mnq1V2FPT0WU
LOXIMVI MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zpc2lEPTB;Mj6wOFA5PCEQvF2= NUToNZB4W0GQR1XS
NH-12 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljtTWM2OD1{LkC1OFI1KM7:TR?= NID6bVJUSU6JRWK=
NCI-H1048 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q0WWlEPTB;Mj6xNFUzKM7:TR?= NEPXe5pUSU6JRWK=
KS-1 M2DpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13mWWlEPTB;Mj6xNVAxOSEQvF2= M{[2SXNCVkeHUh?=
NCI-N87 MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7GbIttUUN3ME2yMlE{Ozh2IN88US=> MVzTRW5ITVJ?
CHP-212 NED5PJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXWNHJIUUN3ME2yMlE5PDR{IN88US=> M37FSnNCVkeHUh?=
HCC1419 NIXHVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvrZ5R[UUN3ME2yMlIyOTF3IN88US=> NEi1cXFUSU6JRWK=
ES1 NFTWd|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV23UXhuUUN3ME2yMlIyOzJ4IN88US=> MVPTRW5ITVJ?
NCI-H2030 MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHZTWM2OD1{LkK0NVI{KM7:TR?= MkLkV2FPT0WU
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EW-13 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7zcG9NUUN3ME23Mlg6QTd5IN88US=> MmrvV2FPT0WU
no-11 NGTQVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTdwOUCxO|Qh|ryP MonBV2FPT0WU
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RH-18 NWnwPGZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXNRm5KUUN3ME24MlM2ODR4IN88US=> MVPTRW5ITVJ?
SW48 NXLld2QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnCTWM2OD16LkW5OFU{KM7:TR?= MUDTRW5ITVJ?
RD Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[ycYJKSzVyPUiuOVk{QTFizszN M2\xVXNCVkeHUh?=
MS-1 NGDkSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXrTWM2OD16Lk[xN|g4KM7:TR?= M3n0S3NCVkeHUh?=
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TE-12 M2riSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRThwN{e1NFUh|ryP NGfCfZhUSU6JRWK=
DBTRG-05MG M2nDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jOV2lEPTB;OD65NVIyPyEQvF2= MYHTRW5ITVJ?
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U-87-MG M2Hv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTlwMkSzNlEh|ryP NUXKWVkxW0GQR1XS
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RXF393 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3ETWM2OD17LkS3NFAzKM7:TR?= NETySppUSU6JRWK=
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RCM-1 M{S4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTlwNkO4NFEh|ryP NF63OWVUSU6JRWK=
SN12C NUT3VVdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTlwNkWzN|gh|ryP MWfTRW5ITVJ?
KLE MkPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTnWZdKSzVyPUmuO|AxODlizszN NH\YS4dUSU6JRWK=
EFO-21 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvUZnE{UUN3ME25Mlc4Ozh{IN88US=> MV\TRW5ITVJ?
KYSE-70 M4nae2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTlwOEiwNVEh|ryP M37j[HNCVkeHUh?=
D-247MG MlTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\3ZYRtUUN3ME2xNE4xPTZ6IN88US=> NXrpPHNCW0GQR1XS
MPP-89 NVLmb|FlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PwNmlEPTB;MUCuNFk1PiEQvF2= NEe3bXhUSU6JRWK=
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NCI-H460 NYi0UWFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm0TWM2OD1zMD6yPFA3KM7:TR?= NEm0dI9USU6JRWK=
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DEL M3rjeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvvTWM2OD1zMD6zO|k1KM7:TR?= MUDTRW5ITVJ?
HT55 M1G0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DDdmlEPTB;MUCuOlIxPSEQvF2= MVTTRW5ITVJ?
MC116 NWO1WlJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zNeGlEPTB;MUCuOlY2PSEQvF2= MYDTRW5ITVJ?
BB30-HNC NEL2cmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECybm5KSzVyPUGwMlY3QSEQvF2= MlLKV2FPT0WU
DJM-1 M1zjNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTFyLk[5OFkh|ryP MYnTRW5ITVJ?
ZR-75-30 NIiyNJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoC4TWM2OD1zMD65OFQyKM7:TR?= M1;IWHNCVkeHUh?=
U-118-MG MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLiR3NxUUN3ME2xNE46QDl4IN88US=> MnLxV2FPT0WU
MSTO-211H MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFzLkC3NVYh|ryP NH7yOW1USU6JRWK=
SW837 MlfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH33cFVKSzVyPUGxMlA6PDlizszN MYfTRW5ITVJ?
HuCCT1 NHzQeo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDkTJZoUUN3ME2xNU4yOjhzIN88US=> MV;TRW5ITVJ?
RCC10RGB M37CR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfRSHF1UUN3ME2xNU4yOzVizszN MYLTRW5ITVJ?
NMC-G1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvFTWM2OD1zMT6xOFk{KM7:TR?= NIK0eoNUSU6JRWK=
NCI-H650 NULzXWZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uwfWlEPTB;MUGuN|c6PCEQvF2= Mn\3V2FPT0WU
HEC-1 MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTxfnlKSzVyPUGxMlQ{OjhizszN MlG3V2FPT0WU
DU-4475 NWHhcJFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzxTWM2OD1zMT63N|k{KM7:TR?= M3rpb3NCVkeHUh?=
DSH1 MlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfZTWM2OD1zMT63OlA3KM7:TR?= MoDqV2FPT0WU
HCC1569 M4PXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTFzLke2O|gh|ryP MWPTRW5ITVJ?
HCC1187 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTDVlczUUN3ME2xNU45PTh6IN88US=> MmX5V2FPT0WU
EW-11 NX[2NVV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED1bYpKSzVyPUGxMlk1PzRizszN NXXV[XFmW0GQR1XS
LB2518-MEL NITTVHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTKTWM2OD1zMj6wOVkh|ryP NV3ZXYZnW0GQR1XS
KALS-1 M2XQSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF{Lki1OVMh|ryP NULnS25bW0GQR1XS
8505C M3XpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3GWJZKSzVyPUGyMlg5PSEQvF2= NUPVe5g1W0GQR1XS
SK-N-DZ M3vFUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7PTWM2OD1zMz6wOFU{KM7:TR?= M1j5[3NCVkeHUh?=
CHP-134 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\C[2lEPTB;MUOuNVE2QCEQvF2= M1;s[HNCVkeHUh?=
HCE-T MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGq5OZpKSzVyPUGzMlI{PjRizszN NHXp[VlUSU6JRWK=
LB-831-BLC NF;IOZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF|Lk[yOFYh|ryP MoK1V2FPT0WU
OVCAR-4 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXESXhKSzVyPUGzMlY2OjRizszN M17PNHNCVkeHUh?=
SW756 NGH5clZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWiwOW06UUN3ME2xN{44OjR4IN88US=> MnXkV2FPT0WU
OCUB-M MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXqSWFuUUN3ME2xN{45OTV4IN88US=> NXvG[3ZjW0GQR1XS
SW982 NEe2VoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHry[|VKSzVyPUGzMlgzPzZizszN NIS2OoFUSU6JRWK=
DB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGWzdVhKSzVyPUGzMlg{QDRizszN NEXRc|RUSU6JRWK=
H-EMC-SS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjvN|hKSzVyPUGzMlkyOzlizszN MVfTRW5ITVJ?
VMRC-RCZ Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLnT3FWUUN3ME2xOE4xODF3IN88US=> NYf4SW5KW0GQR1XS
CAKI-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTF2LkCxN|Ih|ryP NIC0OG9USU6JRWK=
GI-1 MoTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17OWWlEPTB;MUSuNFY2QCEQvF2= NFXiNY5USU6JRWK=
Ca9-22 MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS3NIxKSzVyPUG0MlYxPTRizszN MXjTRW5ITVJ?
TE-5 NHT4d4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTF2LkeyNFgh|ryP NGDEW21USU6JRWK=
EFO-27 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3j[ZVKSzVyPUG0Mlc3OjJizszN NWnzcHl1W0GQR1XS
CAL-72 M{PSdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL2TJJKSzVyPUG0Mlc4QDNizszN MVPTRW5ITVJ?
GP5d NG[y[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HhPGlEPTB;MUWuNFQ4PCEQvF2= MmD1V2FPT0WU
CAS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPwemxKSzVyPUG1MlA3PiEQvF2= MUjTRW5ITVJ?
A2058 MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPCN25IUUN3ME2xOU42PjN6IN88US=> MoXhV2FPT0WU
PANC-08-13 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7WU|JKSzVyPUG1MlY5PTlizszN NEn6Uo5USU6JRWK=
Detroit562 NIXDN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofnTWM2OD1zNT65NVM6KM7:TR?= NF;UZ2tUSU6JRWK=
PANC-10-05 M{PDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7pTWM2OD1zNj6wPFIyKM7:TR?= MnS0V2FPT0WU
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GT3TKB NETIXpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle2TWM2OD1zNj6xPVgyKM7:TR?= Mn\QV2FPT0WU
KM-H2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWL1N3ZkUUN3ME2xOk4{PjR4IN88US=> M3jLPXNCVkeHUh?=
LB771-HNC NXjDbHR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\qT4NKSzVyPUG2MlQ1OjJizszN MWLTRW5ITVJ?
SF268 NI\afVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTF4LkS1NkDPxE1? NXrSdm1lW0GQR1XS
OE19 M1r0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnnXHBsUUN3ME2xOk42OjRizszN M1m0TnNCVkeHUh?=
MLMA NWTrfY9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\u[2lEPTB;MU[uOVU4OSEQvF2= NHTPbGtUSU6JRWK=
MDA-MB-231 M{OxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLiTWM2OD1zNj63NVM3KM7:TR?= M4nicHNCVkeHUh?=
TGW Mlm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF4LkixNFIh|ryP NYq0cmNZW0GQR1XS
MDA-MB-453 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT0PFVKSzVyPUG3MlAxODNizszN MYDTRW5ITVJ?
SNU-C2B MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXJbnRxUUN3ME2xO{4xOjN5IN88US=> NGXSdlZUSU6JRWK=
A427 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[1[WlEPTB;MUeuNlM{PCEQvF2= NU\uemJjW0GQR1XS
SK-MEL-2 NXvaOZJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m5VmlEPTB;MUeuN|IyOyEQvF2= M2P0[XNCVkeHUh?=
KURAMOCHI NWO0PYhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVuxbW9{UUN3ME2xO{4{QDl5IN88US=> MWDTRW5ITVJ?
IST-MEL1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLpTWM2OD1zNz65NVgzKM7:TR?= MYLTRW5ITVJ?
NCI-H1793 NELJTVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2xTWM2OD1zOD6xOVgyKM7:TR?= NIXENFdUSU6JRWK=
HCC1395 NVTYN2FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHVcnpKSzVyPUG4MlU3OTFizszN NEL1Z2xUSU6JRWK=
NUGC-3 M4\TeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ezcmlEPTB;MUiuOlU5PCEQvF2= MnH0V2FPT0WU
BB65-RCC M4r3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\RTWM2OD1zOD62Olkh|ryP Mkj3V2FPT0WU
RMG-I MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjLSnljUUN3ME2xPE44Ozh{IN88US=> NVn1eXRiW0GQR1XS
LS-513 NHO2PFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\vTWM2OD1zOD65NlI5KM7:TR?= MkXhV2FPT0WU
MFM-223 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvGTWM2OD1zOT6wO|E3KM7:TR?= NHftVHdUSU6JRWK=
NCI-H727 MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LBbGlEPTB;MUmuN|I6PSEQvF2= M3HwUXNCVkeHUh?=
KP-4 MnTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoT2TWM2OD1zOT64OVMyKM7:TR?= MknEV2FPT0WU
NB13 M3q3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fSNWlEPTB;MUmuPFg{QSEQvF2= M2DUU3NCVkeHUh?=
UACC-893 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDr[FlWUUN3ME2xPU46PzV5IN88US=> NEDYOI5USU6JRWK=
HT-1197 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJyLkK5OVgh|ryP NUjOW3NyW0GQR1XS
NCI-H2029 NFG5fodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rZNWlEPTB;MkCuN|I3PiEQvF2= NYT5cHl6W0GQR1XS
GI-ME-N Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJyLkOzO|Mh|ryP MkiwV2FPT0WU
OVCAR-3 M2fv[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJyLkW4NlIh|ryP Ml7JV2FPT0WU
HD-MY-Z MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJzLkO2PVYh|ryP M4H3SnNCVkeHUh?=
NTERA-S-cl-D1 NEL3epBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJzLk[3NlIh|ryP NFi5NolUSU6JRWK=
SCH M4XOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLxTWM2OD1{Mj60PVYh|ryP NWjDZXBtW0GQR1XS
KARPAS-299 NUXhR5FwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfLTWM2OD1{Mz6zPFg4KM7:TR?= M1HQfHNCVkeHUh?=
NCI-H1650 NUPlUoh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ|LkmyOFEh|ryP NH\O[YdUSU6JRWK=
ACHN MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESzNWhKSzVyPUK0MlQ3PTZizszN NF7nbIVUSU6JRWK=
M059J NVLvWnR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\YTWM2OD1{ND61OlM1KM7:TR?= MYrTRW5ITVJ?
AM-38 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13uN2lEPTB;MkWuOFgyKM7:TR?= NG\WfFhUSU6JRWK=
KG-1 NIq5XFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;tSI1rUUN3ME2yOU42PDl2IN88US=> M2ryNXNCVkeHUh?=
COLO-824 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL2O5ZIUUN3ME2yOU42PTl7IN88US=> NUS5Xop4W0GQR1XS
NCI-H1155 Ml;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHIRYxKSzVyPUK1MlU5PDdizszN NVvQUGlMW0GQR1XS
NCI-H441 M2PFN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\TTWM2OD1{NT63OFY2KM7:TR?= NIXQWoxUSU6JRWK=
J-RT3-T3-5 NELv[4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ4LkOwNlch|ryP NIiw[JhUSU6JRWK=
JEG-3 NYHVOmUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jIWGlEPTB;Mk[uOlgxPSEQvF2= NH3nZ|BUSU6JRWK=
RKO M1nQZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rHSmlEPTB;Mk[uO|Y{OiEQvF2= NFLCeGFUSU6JRWK=
CAL-85-1 NXvQTIJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILBUWdKSzVyPUK3MlIyOThizszN MXrTRW5ITVJ?
CAL-120 MoTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7WRXNKSzVyPUK3MlY6OTRizszN MVjTRW5ITVJ?
NCI-H2452 NHPPNYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXYO5JKSzVyPUK3Mlc4OTZizszN NYHyTFVoW0GQR1XS
NCI-H1395 NIPwcHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJ5Lke4N|Mh|ryP NYr6W2ZqW0GQR1XS
KYSE-450 NITKeIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2T0WWlEPTB;MkeuPVg3OiEQvF2= NYTiWpB[W0GQR1XS
S-117 M4LNSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ7LkO4OVch|ryP MmLOV2FPT0WU
SW13 MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXOTWM2OD1{OT64OVE6KM7:TR?= M37pfXNCVkeHUh?=
ES3 NXHLOnFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnXUZZMUUN3ME2zNE4{PzN|IN88US=> M4WxSHNCVkeHUh?=
HCT-116 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y5TGlEPTB;M{CuOVU2PCEQvF2= MYfTRW5ITVJ?
NCI-H1693 MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTNyLkW5OFIh|ryP NGnuSVJUSU6JRWK=
VM-CUB-1 MorES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnCTWM2OD1|MD62OFE{KM7:TR?= MoT4V2FPT0WU
NCI-H2170 NETpPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvPSWloUUN3ME2zNU42Pzh2IN88US=> MVvTRW5ITVJ?
ALL-PO MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3JTWM2OD1|MT64OFI5KM7:TR?= NIHWU4xUSU6JRWK=
NCI-H661 MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfKXllWUUN3ME2zNk4xPjJ|IN88US=> NHL3UItUSU6JRWK=
NCI-H2347 MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf1T2F5UUN3ME2zNk41QDN5IN88US=> MUHTRW5ITVJ?
FTC-133 NELYOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPQTWM2OD1|Mj63NFYh|ryP M2TT[XNCVkeHUh?=
COLO-829 NV7OenFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPWXFhLUUN3ME2zN{4{PDZ5IN88US=> NYDIWow3W0GQR1XS
GOTO NVzmSZBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HFSWlEPTB;M{OuOVI2QCEQvF2= M3XK[HNCVkeHUh?=
YAPC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln5TWM2OD1|Mz64NVU6KM7:TR?= M2PN[XNCVkeHUh?=
LCLC-103H NGD0R4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXOTWM2OD1|ND6xOlI1KM7:TR?= M4fOPHNCVkeHUh?=
SiHa NH3l[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfYUI02UUN3ME2zOE4{QDF5IN88US=> NXrlVWZkW0GQR1XS
LK-2 MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P6TWlEPTB;M{SuOVcxQCEQvF2= M{DpeHNCVkeHUh?=
KP-N-YS NFS5PGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnNOm1RUUN3ME2zOE44OjB{IN88US=> MmTnV2FPT0WU
NCI-SNU-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTN3LkG3PUDPxE1? NIrESHhUSU6JRWK=
KNS-81-FD MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXQTWM2OD1|NT62OlMh|ryP MmfOV2FPT0WU
SCC-9 NGD5bIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTN4LkexOFYh|ryP MmjmV2FPT0WU
SH-4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrYTWM2OD1|Nj63N{DPxE1? NYDLSm96W0GQR1XS
HCC-1954 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHVR5dEUUN3ME2zO{4zPzJ7IN88US=> MkHKV2FPT0WU
BALL-1 M4HS[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33NcGlEPTB;M{euOVMyPiEQvF2= MlHTV2FPT0WU
BE-13 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:xOGlEPTB;M{euO|AyQCEQvF2= M1L2eXNCVkeHUh?=
COLO-678 M33Ifmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnXTWM2OD1|Nz65OFM4KM7:TR?= NIT5bpJUSU6JRWK=
SK-MEL-3 NHjlZotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTN6LkKzPVch|ryP MkHJV2FPT0WU
OAW-28 MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{flbmlEPTB;M{iuOlM6KM7:TR?= NHjDe4NUSU6JRWK=
CAMA-1 Mn6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvofGdKSzVyPUO4Mlk3QTFizszN M1XDfHNCVkeHUh?=
C2BBe1 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX36NHlKUUN3ME2zPU45OThizszN MVPTRW5ITVJ?
A3-KAW NV\tSokzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\KOmlEPTB;NECuN|Y3OSEQvF2= M2mxd3NCVkeHUh?=
SK-MEL-24 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPETWM2OD12MD61PVMyKM7:TR?= MmfpV2FPT0WU
KYSE-140 M1;4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf2T4ZRUUN3ME20NE44OTZ3IN88US=> MmLXV2FPT0WU
MOLT-16 NYfaUVZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTRzLkG1N|Yh|ryP MXnTRW5ITVJ?
CFPAC-1 NVrWUYpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXtSlFUUUN3ME20Nk42OjFzIN88US=> MX;TRW5ITVJ?
NB14 MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[zTWM2OD12Mj63NFI4KM7:TR?= M1ziPHNCVkeHUh?=
COLO-792 NUfObpNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPLPGN5UUN3ME20Nk45QTZzIN88US=> NEHGcWRUSU6JRWK=
RH-1 NXv5eXdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\ifYFKSzVyPUSzMlQ5OzZizszN MnTJV2FPT0WU
NCI-H522 Ml\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTR2LkO1Olgh|ryP M{LUTnNCVkeHUh?=
Ca-Ski M3;oTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37DcWlEPTB;NESuPFEyPCEQvF2= M1zD[3NCVkeHUh?=
KGN NIjzZY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHjT2hKSzVyPUS4MlMxPjNizszN NGTUdHZUSU6JRWK=
UACC-62 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTR6LkSwO|Ih|ryP NXnPSFd2W0GQR1XS
NCI-H358 NY\JR|NjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTR7LkOwNVgh|ryP M3;6[nNCVkeHUh?=
LS-411N NVvYNlJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG4NXpKSzVyPUS5MlMyOThizszN NF;1VmtUSU6JRWK=
IST-MES1 NU[1[HJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTR7LkW2NlUh|ryP MUTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]
臨床試験 A Phase I study of GDC-0941 in patients with locally advanced or metastatic solid tumors, Non-Hodgkin's lymphoma, or multiple myeloma (MM) (expansion stage only) for which standard therapy either does not exist or has proven ineffective or intolerable is
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Scintillation proximity assay Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.

細胞アッセイ: [2]

細胞株 SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 48 and 72 hours
実験の流れ Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.

動物実験: [2]

動物モデル NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
製剤 Dissolved in 10% DMSO, 5% Tween 20, 85% water
投薬量 ~150 mg/kg/day
投与方法 Oral gavage

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Pictilisib (GDC-0941) SDF
分子量 513.64
化学式

C23H27N7O3S2

CAS No. 957054-30-7
保管 2年-20℃
6月-80℃in solvent
別名 RG7321
溶解度 (25°C) * In vitro DMSO 44 mg/mL (85.66 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 2% DMSO/30% PEG 300/5% Tween 80/ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine

カスタマーフィードバック (7)


Click to enlarge
Rating
Source Cancer Res, 2011, 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck
Method Western blot, Immunofluorescence staining, flow cytometry
Cell Lines 1205Lu cells
Concentrations 3 µmol/L
Incubation Time 48 h
Results Combined PI3K and BRAF inhibition increased the level of BIM expression in both Western blot and immunofluorescence studies (Fig. A). Consistent with a role for increased AKT signaling suppressing BIM expression in PTEN- cells, dual BRAF and PI3K inhibition increased nuclear FOXO3a localization in the PTEN- cell lines (Fig. B) and enhanced the level of BIM mRNA (Fig. B). the combination of PLX4720 with the PI3K inhibitor GDC-0941 significantly enhanced the levels of apoptosis observed in PTEN melanoma cell lines compared to either the BRAF or PI3K inhibitor alone (Fig. C). Similar results were also observed in a 3D spheroid assay, where combined PLX4720 (3 µmol/L) and LY294002 (10 µmol/L) treatment prevented the recovery of cell growth observed when melanoma spheroids were treated with either drug alone (Fig. D).

Click to enlarge
Rating
Source J Inves Der, 2010, 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck
Method Western blot
Cell Lines Mel-Juso cells, 518A2 cells
Concentrations 0.05–1 µmol/L
Incubation Time 24 h
Results In addition, GDC-0941 treatment blocked the phosphorylation of AKT protein (S473 and T308) at even lower concentrations than PI-103, and S6 protein phosphorylation was blocked at similar concentrations.

Click to enlarge
Rating
Source J Cell Sci, 2012, 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck
Method Western Blot
Cell Lines NMuMG cells
Concentrations 1 μM
Incubation Time 1 h
Results GDC-0941, a specific inhibitor of the class IA PI3K, similarly blocked the TGF-b-induced Akt(S473) phosphorylation, confirming the role of PI3K in the induction of mTORC2 kinase activity by TGF-β (Fig. C).

Click to enlarge
Rating
Source Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck
Method Western blot
Cell Lines Breast cancer cells
Concentrations 0-10 nM
Incubation Time 3 h
Results

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Rating
Source Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck
Method Western blot
Cell Lines T47D cells
Concentrations
Incubation Time 1 h
Results

Click to enlarge
Rating
Source Biochim Biophys Acta, 2012, 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck
Method confocal laser-scanning microscopy
Cell Lines HEK293 cells
Concentrations 1 μM
Incubation Time 30 min
Results Both LY294002 and GDC-0941 markedly attenuated the high-glucose-dependent plasma membrane translocation of DGKδ1, indicating that the event is positively regulated by phosphatidylinositol 3-kinase.

Click to enlarge
Rating
Source Pictilisib (GDC-0941) purchased from Selleck
Method Western blot analysis
Cell Lines MCF-7 cells
Concentrations 0 nM/50 nM/100 nM/400 nM
Incubation Time 24 h
Results GDC-0941 caused a surprising increase in phosphorylation of ERK proteins as well as AKT2 S474. GDC-0941 showed differences in its ability to suppr ess PI3K-dependent signaling across the genotypes. AKT1 mutant cells demonstrated greater residual AKT1 S473 phosphorylation and greater phosphorylation of downstream proteins FOXO 1/3, PRAS40, GSK3β , and p70S6K at equivalent doses of GDC-0941, compared to PIK3CA mutant cells.

文献中の引用 (56)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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