Pictilisib (GDC-0941)

Pictilisib (GDC-0941)は1種の有効なPI3Kα/δ抑制剤です。無細胞試験で、Pictilisib (GDC-0941)はPI3Kα/δに作用する時の IC50値は 3 nM で、p110β (11倍) とp110γ (25倍)に適合な選択性をしています。臨床2期。

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Pictilisib (GDC-0941) 化学構造
分子量: 513.64

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製品説明

  • Compare PI3K Inhibitors
    PI3K製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法
  • Pictilisib (GDC-0941)のメカニズム

製品の説明

生物活性

製品説明 Pictilisib (GDC-0941)は1種の有効なPI3Kα/δ抑制剤です。無細胞試験で、Pictilisib (GDC-0941)はPI3Kα/δに作用する時の IC50値は 3 nM で、p110β (11倍) とp110γ (25倍)に適合な選択性をしています。臨床2期。
ターゲット PI3Kα PI3Kβ PI3Kδ PI3Kγ
IC50 3 nM 33 nM 3 nM 75 nM [1]
In vitro試験 GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
Sf9 MX;LbY5ie2ViQYPzZZk> NHzKdo0yKGh? NV\xUmg6TE2VTx?= NFPqU|RKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHTlcJRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlAxOyEQvF2= NXHLcG1iOTh5NUS2OVQ>
Sf9 NXj4NW5YU2mwYYPlJGF{e2G7 M4TQOFEhcA>? NWP0[mxMTE2VTx?= NFrx[JlKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhUDFyNEetVkBufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? Mn;iNVg4PTR4NUS=
Sf9 M2LCOmtqdmG|ZTDBd5NigQ>? MXyxJIg> Ml;oSG1UVw>? MlmwTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> NYHoUG9IOTh5NUS2OVQ>
Sf9 M2\Lb2tqdmG|ZTDBd5NigQ>? NGnrb5IyKGh? MUfEUXNQ M3rKNGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wN|Mh|ryP MnS1NVg4PTR4NUS=
Sf9 M4f0OWtqdmG|ZTDBd5NigQ>? M3:5OFEhcA>? M2S4SmROW09? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGGucHjhJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjh MmHKNVg4PTR4NUS=
MDA-MB-361 NX7hbpQzTnWwY4Tpc44hSXO|YYm= NGWyXoIzKGh? NVnp[HdLTE2VTx?= MkDBTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4xOjhizszN M1TSNVE5PzV2NkW0
PC3 NF7qZpRHfW6ldHnvckBCe3OjeR?= MWGyJIg> NULHeoRVTE2VTx?= NGW1TItKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDQR|Mh[2WubIOge4l1cCCLQ{WwJI9nKDBwMEO3JO69VQ>? M3\SSlE5PzV2NkW0
U87MG NUPqcGhRTnWwY4Tpc44hSXO|YYm= NWLxSoFNOiCq MmPlSG1UVw>? NWLJN2NTUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gWVg4VUdiY3XscJMhf2m2aDDJR|UxKG:oIECuNFQ3KM7:TR?= M4XKXVE5PzV2NkW0
MDA-MB-361 NIfPO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjnPVYhcA>? MXvEUXNQ MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= MnPXNVg4PTR4NUS=
A2780 MlHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1foOFk3KGh? NXXMU5lnTE2VTx?= M{e4e2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUK3PFAh[2WubIOge4l1cCCSSVuzR2Eh[W6mIGDUSW4hdXW2YYTpc44hf2m2aDDJR|UxKG:oIECuNVQh|ryP NV25XXc2OTh5NUS2OVQ>
PC3 NFXlVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU[5OkBp MV;EUXNQ MmHvTWM2OD1yLkK4JO69VQ>? MX6xPFc2PDZ3NB?=
U87MG M{CzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLsPVYhcA>? Mon5SG1UVw>? M{\pemlEPTB;MD65OUDPxE1? MV:xPFc2PDZ3NB?=
Sf9 MWXLbY5ie2ViQYPzZZk> MVmzNEBucW5? MV7EUXNQ M4\QcWlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDhcY92dnRib3[gRXRRKGOxboP1cYVlKHerdHigTWM2OCCxZjCwMlA1OiEQvF2= NHz4dGozOjV2OEO0Ni=>
RAW 264.7 NV3kSXlKU2mwYYPlJGF{e2G7 NULMNJBUQTBibXnu NGexVYtFVVOR MYjJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCU1RicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlI6QCEQvF2= MV6yNlU1QDN2Mh?=
Sf9 Mn2zT4lv[XOnIFHzd4F6 NUXuTnRWOSCq M4\rWGlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tj\XSjIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVRkmgZ4VtdHNid3n0bEBKSzVyIH;mJFAvODF5IN88US=> MWGyN|U1ODZ2NR?=
Sf9 NUjwbnluU2mwYYPlJGF{e2G7 Mkf2NUBp NFzGUYpKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM\GWudHGg[ZhxemW|c3Xk Mn3wNlM2PDB4NEW=
Sf9 NIDsNJNMcW6jc3WgRZN{[Xl? MnfvNUBp MoL0TY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4didW2jIHX4dJJme3OnZB?= NUX3cph2OjN3NEC2OFU>
Sf9 M4X3eWtqdmG|ZTDBd5NigQ>? NY\jcFI3OSCq NES3d2tKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[WyyaHGg[ZhxemW|c3Xk M3fHfFI{PTRyNkS1
SKOV3 NEjL[m1McW6jc3WgRZN{[Xl? MWmxJO69VQ>? NW\pXXJoOSCq MWnEUXNQ NX;CTJBsUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= NUKwdo5KOjN|NkCzOFg>
MCF7 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvrNUDPxE1? Mk[4PVYhcA>? NFvvU2FFVVOR NIHxOXVIUTVyPUCuNFcxOiEQvF2= MXmyN|M3ODN2OB?=
SKOV3 MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXGxS|M2OSEQvF2= MUW5OkBp NVr2OYloTE2VTx?= M3;YcGdKPTB;MD6xOFc3KM7:TR?= M{PW[lI{OzZyM{S4
PC3 M1jyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX0O|IhcA>? NWnXd4pRTE2VTx?= MkfmTWM2OD1yLkK4JO69VQ>? M2jJcVIyQThzN{G0
MCF7.1 NVXkUpJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUm3NkBp M2jIfWROW09? Mk\XRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BJTVJ{IHflcoUhf2m2aDDJR|UxKG:oIECuNlgh|ryP NHT3VnMzOTl6MUexOC=>
MCF7-neo/Her2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPiZoFYPzJiaB?= M4LMVWROW09? M2XIPWlEPTB;MD6yPUDPxE1? MkWyNlM3PjJ7MEO=
MCF7-neo/Her2 MoGyT4lv[XOnIFHzd4F6 Ml61TY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKEGNVDDwbI9{eGixconsZZRqd25iYYSgV|Q4OyC5aYToJGlEPTBib3[gNE4xODdizszN NFLTWYczOzZ4MkmwNy=>
PC3 NIfPTZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XhPVczKGh? MXnEUXNQ MmfiSWM2OD1yLkO0JO69VQ>? NYDmb3JMOjF7OEW2N|k>
MCF7.1 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;4dIxwPzJiaB?= M1vYTWROW09? MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCHQ{WwJI9nKDBwM{mg{txO M2H2T|IyQTh3NkO5
PC3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUi3NkBp NVG2c2lPTE2VTx?= MkD4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiZHXmbYNq\W62IHnuJHBVTU5id3n0bEBKSzVyIH;mJFAvOzlizszN M2jrTVIxODVyNk[5
MCF7.1 NYDt[VVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XmTVczKGh? M3jiXGROW09? M1PNWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFnDOVAhd2ZiMD6zOEDPxE1? MkT1NlAxPTB4Nkm=
MCF7.1 NY\HdWJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LhSVczKGh? NUjVWnhJTUN3ME2wMlczKM7:TR?= Mn3CNlA{PDZ4NU[=
NCI-H1975 NX\yOHY6S3m2b4TvfIlkKEG|c3H5 MVu3NkBp NFjRd2pKSzVyPUCuNlch|ryP MlnUNlMxPTl3NEW=
H460 MkTsR5l1d3SxeHnjJGF{e2G7 M2W3fVczKGh? NIDr[pRKSzVyPUCuPFch|ryP NX;WVHN4OjNyNUm1OFU>
HT-29 MVzDfZRwfG:6aXOgRZN{[Xl? NEjBXlE4OiCq NXrheIloUUN3ME2wMlY3KM7:TR?= MUGyN|A2QTV2NR?=
HepG2 M{jM[mN6fG:2b4jpZ{BCe3OjeR?= NFHRSok4OiCq NV3iVmpFUUN3ME2xJO69VQ>? MlfGNlMxPTl3NEW=
SGC7901 M{D0UGN6fG:2b4jpZ{BCe3OjeR?= MmrkO|IhcA>? MoC3TWM2OD1zLkig{txO M2\L[FI{ODV7NUS1
NCI-H226 NVjxPYp1S3m2b4TvfIlkKEG|c3H5 NInqSHE4OiCq Mn7ZTWM2OD1{Lkmg{txO NYjBOoJtOjNyNUm1OFU>
A549 NHex[ohEgXSxdH;4bYMhSXO|YYm= MoqyO|IhcA>? M1XRemlEPTB;Nj65JO69VQ>? NWLSR2ZbOjNyNUm1OFU>
U87MG MXTDfZRwfG:6aXOgRZN{[Xl? M1rHXFczKGh? MXPJR|UxRTdwN{eg{txO M{n3fFI{ODV7NUS1
HBC4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OzWYxw\0eLNUC9MVYvODNiTR?= MV:yNlM{PjJ2Nh?=
BSY1 NYHoV2JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjOcI9oT0l3ME2tOk46OCCP MXOyNlM{PjJ2Nh?=
HBC5 NVexbGhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLzOZBtd2eJSUWwQU03NjZyIF2= NYXQSXc5OjJ|M{[yOFY>
MCF7 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rnUIxw\0eLNUC9MVcvOzNiTR?= NGjXcZgzOjN|NkK0Oi=>
MDA-MB-231 NWHpdYsxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrNbIpOdG:pR1m1NF0uPS52NjDN NXvnUG5JOjJ|M{[yOFY>
U251 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjsc4dIUTVyPT21MlUxKE1? MmfPNlI{OzZ{NE[=
SF268 M{fhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO5WIhtd2eJSUWwQU02NjN7IF2= M2LVdVIzOzN4MkS2
SF295 NXO2U4V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j3WIxw\0eLNUC9MVYvOzdiTR?= NEjOW48zOjN|NkK0Oi=>
SF539 M2[ydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXGR5RVdG:pR1m1NF0uPi53MDDN NYG2TlV{OjJ|M{[yOFY>
SNB75 Mor0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nrNIxw\0eLNUC9MVcvOTBiTR?= MXmyNlM{PjJ2Nh?=
SNB78 M17Kb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LqTIxw\0eLNUC9MVYvPTJiTR?= NVHVSXM1OjJ|M{[yOFY>
HCC2998 NHLTR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq1cI9oT0l3ME2tOk4zQSCP NIPvVJozOjN|NkK0Oi=>
KM12 MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[wcI9oT0l3ME2tOU44PiCP M{TQO|IzOzN4MkS2
HT-29 NXjJVmVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjGfXBOdG:pR1m1NF0uPi5|MDDN NV;vOY43OjJ|M{[yOFY>
HCT15 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P3T4xw\0eLNUC9MVYvOTJiTR?= NHricXMzOjN|NkK0Oi=>
HCT116 M4fMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LVUIxw\0eLNUC9MVUvQDdiTR?= NXPBd3NYOjJ|M{[yOFY>
NCI-H23 NWmz[HpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\vd4xw\0eLNUC9MVUvPzNiTR?= NGHOcHIzOjN|NkK0Oi=>
NCI-H226 NEHmSm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PhPYxw\0eLNUC9MVYvOjFiTR?= Mon4NlI{OzZ{NE[=
NCI-H522 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrLOVhtd2eJSUWwQU03NjV6IF2= NH\RTlAzOjN|NkK0Oi=>
NCI-H483 MkO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;zS2ltd2eJSUWwQU03NjV4IF2= NH\DXJMzOjN|NkK0Oi=>
A549 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHEcI9oT0l3ME2tOk4yPSCP NY[5SWFxOjJ|M{[yOFY>
DMS273 MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoflcI9oT0l3ME2tOk41OyCP NFHvN24zOjN|NkK0Oi=>
DMS114 M2n6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f1[Yxw\0eLNUC9MVUvQTJiTR?= M1L6WFIzOzN4MkS2
LOXIMVI MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrsc4dIUTVyPT22MlI6KE1? MYeyNlM{PjJ2Nh?=
OVCAR3 M1K0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv2cI9oT0l3ME2tOk44OSCP NH\1d2czOjN|NkK0Oi=>
OVCAR4 NXG5UGxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP6dlN3dG:pR1m1NF0uPS55NjDN NIP1PFIzOjN|NkK0Oi=>
OVCAR5 M2WxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fUPYxw\0eLNUC9MVYvOjZiTR?= M13Jd|IzOzN4MkS2
OVCAR8 NU\sWWdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TUNoxw\0eLNUC9MVUvPzNiTR?= NF;tPZEzOjN|NkK0Oi=>
SKOV3 M2\vNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3qXHZidG:pR1m1NF0uPi53MjDN MknCNlI{OzZ{NE[=
RXF631L M{nMWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP2c2RidG:pR1m1NF0uPi56ODDN NFfWVlUzOjN|NkK0Oi=>
ACHN MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDYRWNtd2eJSUWwQU03NjB5IF2= NGG0W|AzOjN|NkK0Oi=>
St-4 NGfD[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfsc4dIUTVyPT21MlU3KE1? MnjENlI{OzZ{NE[=
MKN1 MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PPboxw\0eLNUC9MVcvODhiTR?= NWC4XlFUOjJ|M{[yOFY>
MKN7 Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPsVnRDdG:pR1m1NF0uPi53MDDN NVHrRm5OOjJ|M{[yOFY>
MKN28 M{i5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrsc4dIUTVyPT21MlUzKE1? NULSO2Z1OjJ|M{[yOFY>
MKN45 NHfubm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG3VFE{dG:pR1m1NF0uPi53NTDN MUWyNlM{PjJ2Nh?=
MKN74 NEW3NFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3sc4dIUTVyPT22MlAzKE1? M{j3WFIzOzN4MkS2
DU145 NHm2N5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfJcI9oT0l3ME2tOU45PSCP MViyNlM{PjJ2Nh?=
PC3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzsc4dIUTVyPT22MlY3KE1? MlHQNlI{OzZ{NE[=
ES5 NHPoV3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vVSWlEPTB;NUCuNlEhdk1? NGrDNnVUSU6JRWK=
HH NEHvRVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHVfJNKSzVyPUGxNU4xQCCwTR?= MoXNV2FPT0WU
MHH-PREB-1 NXLt[XNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLNcoRkUUN3ME2xNVQvOyCwTR?= NWTofpRLW0GQR1XS
NCI-H1770 NV70UGZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Xne2lEPTB;MUKzMlg3KG6P NXv2Zoo4W0GQR1XS
HuO9 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVr6XpI2UUN3ME2yNFYvODJibl2= MXHTRW5ITVJ?
HAL-01 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTHTWM2OD1{ME[uO|Mhdk1? MVvTRW5ITVJ?
NOS-1 MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITveIRKSzVyPUKxNU45OiCwTR?= NWPtOpU4W0GQR1XS
HGC-27 M3f4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[3TWM2OD1{MUKuOVchdk1? NUi1cWlzW0GQR1XS
NB69 M33VTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJ2NT6yO{BvVQ>? NHHWSoNUSU6JRWK=
RS4-11 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nZcGlEPTB;Mk[xMlc3KG6P M{fSdXNCVkeHUh?=
DOK NWP4OoJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjyWG1KSzVyPUOwNU44KG6P MV;TRW5ITVJ?
LB2241-RCC NYThOJc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4na[GlEPTB;M{CzMlg1KG6P MljKV2FPT0WU
NCI-H1623 NYD4dXRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;IZ25KSzVyPUOwOE4xQCCwTR?= MmLvV2FPT0WU
YH-13 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfJZ|lnUUN3ME2zNFQvOzJibl2= M{i1XnNCVkeHUh?=
BPH-1 NE\Dd|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmOwTWM2OD1|MUSgcm0> MVTTRW5ITVJ?
AN3-CA MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzkTWM2OD1|NECuN|chdk1? M{\Y[nNCVkeHUh?=
ES7 NVvkUYhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPTTWM2OD1|NEGuPVkhdk1? NVG0NFBOW0GQR1XS
MDA-MB-175-VII M33SdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV30cIlIUUN3ME2zOVIvQTJibl2= MVrTRW5ITVJ?
GAMG NIT0SGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHXTWM2OD1|N{CuPFUhdk1? M2XtcnNCVkeHUh?=
CHL-1 M4DCV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3rTWM2OD1|N{iuOlUhdk1? M3;qNXNCVkeHUh?=
NB7 MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTN6OT64N{BvVQ>? MWDTRW5ITVJ?
MFE-280 NVH0SpFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HsOGlEPTB;NEG4MlIhdk1? M131T3NCVkeHUh?=
HL-60 NVv4TIcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXWRVJQUUN3ME20NlUvPzVibl2= NYTDNVZmW0GQR1XS
GCIY MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PhdmlEPTB;NEOzMlghdk1? NYHabFhTW0GQR1XS
MDA-MB-361 M4f4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m3WGlEPTB;NEO5MlE{KG6P M2HLXHNCVkeHUh?=
LXF-289 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTR2OD6yO{BvVQ>? M2\K[HNCVkeHUh?=
NBsusSR NGnBOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmwbpR[UUN3ME20PFgvQDVibl2= M1z4TnNCVkeHUh?=
KU-19-19 NXXNTYwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUewb5NvUUN3ME21NVYvODdibl2= MXHTRW5ITVJ?
A204 NUfCc3VsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfPPG9CUUN3ME21NlIvOzNibl2= MlHhV2FPT0WU
LB1047-RCC MojiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLmTWM2OD13MkKuPVMhdk1? M17YUHNCVkeHUh?=
COLO-684 NV\KO|A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\0XmlEPTB;NUKzMlEyKG6P NVuxbpVPW0GQR1XS
PA-1 MoLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTB[4tKSzVyPUWzNk41OSCwTR?= NWLMfIw1W0GQR1XS
MG-63 NX;QcXc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTV2MT6xNUBvVQ>? NHj2cphUSU6JRWK=
BHT-101 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\zN5hKSzVyPUW0OE46PCCwTR?= M1nNbnNCVkeHUh?=
NKM-1 NEDZOI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHniOVlKSzVyPUW5N{4xQSCwTR?= NVTMPGtoW0GQR1XS
T47D M1G4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTV7Nz61OkBvVQ>? MoXkV2FPT0WU
MOLT-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rldmlEPTB;NkKzMlYzKG6P MlPDV2FPT0WU
IGROV-1 Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX5TWM2OD14M{SuN|Ehdk1? NUTNcldqW0GQR1XS
ES4 M33FOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHuTWM2OD14M{muOVQhdk1? NIHUSJBUSU6JRWK=
HuO-3N1 NFnCN5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTZ2Mj6zPEBvVQ>? NV\uS2FUW0GQR1XS
NEC8 Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2S3SmlEPTB;NkWzMlU4KG6P M1LP[3NCVkeHUh?=
HO-1-N-1 NVXFc2ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPXTWM2OD14NUmuNVchdk1? MYDTRW5ITVJ?
EPCL-272H NXvnc5U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LjUGlEPTB;Nki3MlIyKG6P NHPuT|lUSU6JRWK=
D-263MG M{Gwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Pje2lEPTB;N{G4MlEhdk1? NX[yRZU4W0GQR1XS
MV-4-11 MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTd{ND6zNUBvVQ>? MlHyV2FPT0WU
SK-NEP-1 M3\2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPhTWM2OD15MkWuPVQhdk1? M1eye3NCVkeHUh?=
SW872 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fhSGlEPTB;N{K3Mlg6KG6P NUXQNnlIW0GQR1XS
P30-OHK MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG4TWM2OD15M{CuO|Ehdk1? M13lTnNCVkeHUh?=
OMC-1 M2P2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHyTWM2OD15NUGuNFkhdk1? MmHoV2FPT0WU
LoVo M2jZ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HRS2lEPTB;N{e3Mlkhdk1? NGm0ZnpUSU6JRWK=
LNCaP-Clone-FGC MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHwTWM2OD15OU[uN|Qhdk1? Ml7iV2FPT0WU
L-363 NWrXe2NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvxTWM2OD15OUiuOFIhdk1? NV\ueohIW0GQR1XS
ES8 M1O4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoiwTWM2OD16MUCuOVIhdk1? M4S0PHNCVkeHUh?=
697 NHvBRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;me2lEPTB;OEOxMlU2KG6P MkjyV2FPT0WU
HSC-3 NV;JZ2dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTh|OT61OEBvVQ>? NGPhcGxUSU6JRWK=
H4 NX3tenRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\NZ|ZkUUN3ME24OVAvQDVibl2= NVjnUpBIW0GQR1XS
QIMR-WIL NXKzeWRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjTbHBMUUN3ME24OlUvOiCwTR?= M3uxc3NCVkeHUh?=
OAW-42 NEC3NIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DnSWlEPTB;OEeyMlE6KG6P M1i1[XNCVkeHUh?=
MCF7 NFHJ[GZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzYRo1MUUN3ME24PVgvPTlibl2= MkDmV2FPT0WU
SCC-25 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPhN3hKSzVyPUmxOE4yQSCwTR?= MnqyV2FPT0WU
NCI-H1563 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvFTWM2OD17MUWuPVkhdk1? M1[zZ3NCVkeHUh?=
OVCAR-5 M2\MfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7wRXNFUUN3ME25OFAvOTdibl2= NFPPeotUSU6JRWK=
HDLM-2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTl2OT6yJI5O MmX2V2FPT0WU
NB5 M4Hp[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfsdZd[UUN3ME25OVYvPiCwTR?= NY\ZSnF2W0GQR1XS
NCI-H292 NVrOW4dsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXFTWM2OD17N{SuN|Ihdk1? MW\TRW5ITVJ?
A101D M3XWPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfFV|JKSzVyPUm5NE4yQSCwTR?= Ml7MV2FPT0WU
NCI-H1648 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PXXGlEPTB;OUm4MlUyKG6P M1j5OnNCVkeHUh?=
EKVX NGDNdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fHZmlEPTB;MT6wNVI6KM7:TR?= NWTES2pvW0GQR1XS
SW1710 Ml31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFwMESyN|Mh|ryP MXvTRW5ITVJ?
WM-115 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DuW2lEPTB;MT6wOlY2PiEQvF2= MYTTRW5ITVJ?
CAL-54 Mn3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTFwMEewPFEh|ryP MnPxV2FPT0WU
TGBC24TKB MkjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojCTWM2OD1zLkC4NFQ2KM7:TR?= MX3TRW5ITVJ?
NCI-H520 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfEfJBKSzVyPUGuNFg6PjdizszN NXGyNXdlW0GQR1XS
D-423MG NFGwUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrMZpFIUUN3ME2xMlA6QTZ{IN88US=> MkP4V2FPT0WU
BFTC-905 NILmU3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\VTWM2OD1zLkGzOFQ6KM7:TR?= MnLyV2FPT0WU
HT NEDRXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfrVHJKSzVyPUGuNVM1PzhizszN MnThV2FPT0WU
CTB-1 M{[2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXRW4tKSzVyPUGuNVQzQTNizszN NV;JdolOW0GQR1XS
Hs-578-T MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkflTWM2OD1zLkG5OVY2KM7:TR?= M{\FUXNCVkeHUh?=
HuH-7 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjEOVQ5UUN3ME2xMlIxQTR7IN88US=> MUHTRW5ITVJ?
LB996-RCC NX3qTlJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInmXI9KSzVyPUGuNlIyPzdizszN MYDTRW5ITVJ?
KYSE-270 Mlz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFwMkm3N|Qh|ryP MXHTRW5ITVJ?
A4-Fuk MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoCxTWM2OD1zLkK5PVk{KM7:TR?= M4TPe3NCVkeHUh?=
A498 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTMTWM2OD1zLkOwOFc1KM7:TR?= M2\CcXNCVkeHUh?=
SK-MEL-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzaTWM2OD1zLkOwOlc6KM7:TR?= NFrUVFhUSU6JRWK=
AU565 NGLNTWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17SfGlEPTB;MT6zNVg3OyEQvF2= NWHRd29KW0GQR1XS
Saos-2 MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7GO3hKSzVyPUGuN|MzODVizszN NH\mfWxUSU6JRWK=
A549 NGjOVolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\ublVxUUN3ME2xMlM6QTdizszN MoniV2FPT0WU
BFTC-909 MnvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K2dWlEPTB;MT60N|MxPSEQvF2= M1jVOnNCVkeHUh?=
MDA-MB-415 M4e5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFwNEi2PVIh|ryP M4DzO3NCVkeHUh?=
639-V NIW2VJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{KwSmlEPTB;MT61NFI1PSEQvF2= NFPMeHlUSU6JRWK=
A704 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TBcmlEPTB;MT61NFc5PSEQvF2= M37uS3NCVkeHUh?=
PANC-03-27 NH7FXXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrSTWM2OD1zLkWxOFA5KM7:TR?= NFHze21USU6JRWK=
SK-MEL-28 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XlVWlEPTB;MT61OlA5PSEQvF2= M1jLUXNCVkeHUh?=
Ramos-2G6-4C10 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TWfGlEPTB;MT62NFc1PiEQvF2= NVzQXZpVW0GQR1XS
HuP-T4 NFrrR5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTFwNkC3O|gh|ryP MnPBV2FPT0WU
VA-ES-BJ NIjGe|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\yVpFKSzVyPUGuOlEzPyEQvF2= M1fXZnNCVkeHUh?=
EFM-19 NULyTFBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvmVIdVUUN3ME2xMlYyQDFizszN NGnkPIVUSU6JRWK=
G-401 NXnYeWhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonvTWM2OD1zLk[yNVY1KM7:TR?= M3Wzd3NCVkeHUh?=
D-566MG MmXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDaVGNKSzVyPUGuOlI2OyEQvF2= M1PmR3NCVkeHUh?=
JVM-3 NVvmOWpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPFflFVUUN3ME2xMlY1QDd3IN88US=> MoLLV2FPT0WU
TK10 NYnvNJFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFwNkewPFMh|ryP MXTTRW5ITVJ?
BT-20 NHzZcFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2robGlEPTB;MT62PFkxOiEQvF2= NYjONppjW0GQR1XS
EGI-1 MoSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1i4ZWlEPTB;MT64OFcxOSEQvF2= Mlf3V2FPT0WU
EW-16 NFTRPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jCSWlEPTB;MT64OVE5OiEQvF2= MXzTRW5ITVJ?
NCI-H2228 M3Hxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfLWXllUUN3ME2xMlg2OjB|IN88US=> NGXTfmtUSU6JRWK=
BB49-HNC M1W2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFwOEi2PVIh|ryP Ml7LV2FPT0WU
G-402 NHnoZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoGxTWM2OD1zLki5O|k4KM7:TR?= M{iwc3NCVkeHUh?=
NCI-H526 M4i2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFwOUGzPUDPxE1? MUDTRW5ITVJ?
ME-180 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED1OWNKSzVyPUGuPVM1PzdizszN M3vaWHNCVkeHUh?=
PFSK-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrBOHc{UUN3ME2xMlk1PDV6IN88US=> NF\5Z5pUSU6JRWK=
TYK-nu NUnwPGdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTFwOUW4NlMh|ryP MVnTRW5ITVJ?
HOS M37XZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELvR3hKSzVyPUGuPVc6PDhizszN MWXTRW5ITVJ?
T98G M3XwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LiOWlEPTB;MT65PVAxPiEQvF2= NVH4UWtVW0GQR1XS
SK-MES-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jwV2lEPTB;Mj6wNVM{OiEQvF2= MkLaV2FPT0WU
SNB75 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T6eGlEPTB;Mj6wNVU1OSEQvF2= NUC3NFdZW0GQR1XS
LAMA-84 NGHUUnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP3TWM2OD1{LkCyOlg6KM7:TR?= M3PvS3NCVkeHUh?=
CAL-39 NYricXhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf2Zm5oUUN3ME2yMlA{OjhizszN NVjV[3VXW0GQR1XS
LOXIMVI NUPVSmduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{GyZWlEPTB;Mj6wOFA5PCEQvF2= M2LlVHNCVkeHUh?=
NH-12 M1fYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPXe4JIUUN3ME2yMlA2PDJ2IN88US=> NEfzZXVUSU6JRWK=
NCI-H1048 MoLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zsc2lEPTB;Mj6xNFUzKM7:TR?= MXrTRW5ITVJ?
KS-1 M3XlPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXWeZZKSzVyPUKuNVExODFizszN MVXTRW5ITVJ?
NCI-N87 M3OweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H5cWlEPTB;Mj6xN|M5PCEQvF2= MnHLV2FPT0WU
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DEL MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\ifFZuUUN3ME2xNE4{Pzl2IN88US=> M4WwTHNCVkeHUh?=
HT55 NHWyVWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrJbpRQUUN3ME2xNE43OjB3IN88US=> NU\iWGhwW0GQR1XS
MC116 M{D4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LKUmlEPTB;MUCuOlY2PSEQvF2= NYXKd|A1W0GQR1XS
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MSTO-211H M4LmN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETJRllKSzVyPUGxMlA4OTZizszN Mnj4V2FPT0WU
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HuCCT1 MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnmyTWM2OD1zMT6xNlgyKM7:TR?= MX;TRW5ITVJ?
RCC10RGB MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzUVXlKSzVyPUGxMlE{PSEQvF2= NV;GNGxnW0GQR1XS
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NCI-H650 Moe2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTFzLkO3PVQh|ryP M{LvZXNCVkeHUh?=
HEC-1 MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\5eGlEPTB;MUGuOFMzQCEQvF2= MmLIV2FPT0WU
DU-4475 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv2NphbUUN3ME2xNU44Ozl|IN88US=> NVjkR4FjW0GQR1XS
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HCC1569 MorqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\OZVFuUUN3ME2xNU44Pjd6IN88US=> MUfTRW5ITVJ?
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LB2518-MEL NXrOemFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF{LkC1PUDPxE1? M4\1b3NCVkeHUh?=
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CHP-134 NHn1[o9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPGc4R6UUN3ME2xN{4yOTV6IN88US=> NGTobY9USU6JRWK=
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LB-831-BLC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF|Lk[yOFYh|ryP M{PBV3NCVkeHUh?=
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DB NHiwbVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTF|LkizPFQh|ryP NGP2SHNUSU6JRWK=
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TE-5 NFfpOWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH0OWdMUUN3ME2xOE44OjB6IN88US=> NID3T|VUSU6JRWK=
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CAL-72 MnH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH:3WHJKSzVyPUG0Mlc4QDNizszN M3vadXNCVkeHUh?=
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Detroit562 MlvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL1TWM2OD1zNT65NVM6KM7:TR?= M1rDTnNCVkeHUh?=
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MDA-MB-231 MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PqdWlEPTB;MU[uO|E{PiEQvF2= NF7KZ4RUSU6JRWK=
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MFM-223 Mnm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF7LkC3NVYh|ryP MkLrV2FPT0WU
NCI-H727 NXTsOGt5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDPcW5LUUN3ME2xPU4{Ojl3IN88US=> Ml6zV2FPT0WU
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NB13 NWnUc5dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvqZYNKSzVyPUG5Mlg5OzlizszN MYHTRW5ITVJ?
UACC-893 M2DLU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELqW41KSzVyPUG5Mlk4PTdizszN NXTqNFN6W0GQR1XS
HT-1197 M4DnSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rqOGlEPTB;MkCuNlk2QCEQvF2= M3ziVnNCVkeHUh?=
NCI-H2029 NYLzUnFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XCNWlEPTB;MkCuN|I3PiEQvF2= MlrjV2FPT0WU
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OVCAR-3 M2Lobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnxelVNUUN3ME2yNE42QDJ{IN88US=> NEG4Z|lUSU6JRWK=
HD-MY-Z NVzj[G01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK4TWM2OD1{MT6zOlk3KM7:TR?= NFH2NmpUSU6JRWK=
NTERA-S-cl-D1 NYXuR5lkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3uTWM2OD1{MT62O|IzKM7:TR?= NY\sTpVIW0GQR1XS
SCH M17pSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jGTmlEPTB;MkKuOFk3KM7:TR?= NGfvcGlUSU6JRWK=
KARPAS-299 NWXQc29tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK0TWM2OD1{Mz6zPFg4KM7:TR?= NXm1cYZ5W0GQR1XS
NCI-H1650 NELrfVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJ|LkmyOFEh|ryP MVjTRW5ITVJ?
ACHN NFL0RpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3hTWM2OD1{ND60OlU3KM7:TR?= MnSxV2FPT0WU
M059J M3;RbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4O3T2lEPTB;MkSuOVY{PCEQvF2= NWDLNXNZW0GQR1XS
AM-38 MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\QUWlEPTB;MkWuOFgyKM7:TR?= NFm3VnNUSU6JRWK=
KG-1 NEHNe3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPyTWM2OD1{NT61OFk1KM7:TR?= NGTO[4dUSU6JRWK=
COLO-824 NHr2PZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPmTWM2OD1{NT61OVk6KM7:TR?= M3SyUXNCVkeHUh?=
NCI-H1155 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJ3LkW4OFch|ryP NHf2XIhUSU6JRWK=
NCI-H441 NVPyO4lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\HS5NWUUN3ME2yOU44PDZ3IN88US=> M2i5OnNCVkeHUh?=
J-RT3-T3-5 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fZZWlEPTB;Mk[uN|AzPyEQvF2= NWj6Uno4W0GQR1XS
JEG-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP2TWM2OD1{Nj62PFA2KM7:TR?= MXjTRW5ITVJ?
RKO M3fGOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjRSIhKSzVyPUK2Mlc3OzJizszN MnHrV2FPT0WU
CAL-85-1 NF\TbJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzVOWNyUUN3ME2yO{4zOTF6IN88US=> NXnE[WRCW0GQR1XS
CAL-120 NGfZRllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3TfGJMUUN3ME2yO{43QTF2IN88US=> M3rjZXNCVkeHUh?=
NCI-H2452 M2nKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfoWmpKSzVyPUK3Mlc4OTZizszN MUTTRW5ITVJ?
NCI-H1395 NVzEfJR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzYbJhKSzVyPUK3Mlc5OzNizszN MlLxV2FPT0WU
KYSE-450 M2rJfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDDTWM2OD1{Nz65PFYzKM7:TR?= MnLCV2FPT0WU
S-117 NUGwd25vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjaOpkzUUN3ME2yPU4{QDV5IN88US=> MlPwV2FPT0WU
SW13 NHLYb5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfKfnRYUUN3ME2yPU45PTF7IN88US=> NXq0OmtIW0GQR1XS
ES3 NHLBe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTNyLkO3N|Mh|ryP M3\UU3NCVkeHUh?=
HCT-116 NUG2XoN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTNyLkW1OVQh|ryP NXG4bJlDW0GQR1XS
NCI-H1693 NWDj[29FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonrTWM2OD1|MD61PVQzKM7:TR?= NXfrVlNMW0GQR1XS
VM-CUB-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[1bYM3UUN3ME2zNE43PDF|IN88US=> NXr2b5Y4W0GQR1XS
NCI-H2170 MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjNWYE{UUN3ME2zNU42Pzh2IN88US=> NGLUN5NUSU6JRWK=
ALL-PO NY\tNo84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTNzLki0Nlgh|ryP NWHKVY5kW0GQR1XS
NCI-H661 MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLLTWM2OD1|Mj6wOlI{KM7:TR?= MWPTRW5ITVJ?
NCI-H2347 NEXVUZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nHcGlEPTB;M{KuOFg{PyEQvF2= MnLDV2FPT0WU
FTC-133 MmPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTN{LkewOkDPxE1? NHmxOpVUSU6JRWK=
COLO-829 NXHWPWMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITkdG9KSzVyPUOzMlM1PjdizszN MYTTRW5ITVJ?
GOTO NU\U[ZRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HxSmlEPTB;M{OuOVI2QCEQvF2= M1TUZnNCVkeHUh?=
YAPC MojTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XKeWlEPTB;M{OuPFE2QSEQvF2= M2roR3NCVkeHUh?=
LCLC-103H MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvPTI8zUUN3ME2zOE4yPjJ2IN88US=> NUnCXm1YW0GQR1XS
SiHa NIriXotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLHTWM2OD1|ND6zPFE4KM7:TR?= MXjTRW5ITVJ?
LK-2 NG\PRnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2SwfmlEPTB;M{SuOVcxQCEQvF2= NVG0cnBmW0GQR1XS
KP-N-YS M1;Pdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[2OIpKSzVyPUO0MlczODJizszN MYrTRW5ITVJ?
NCI-SNU-1 NHL0enpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvtdpVKSzVyPUO1MlE4QSEQvF2= NWTiPWVQW0GQR1XS
KNS-81-FD NVLL[ppTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXtO4lKSzVyPUO1MlY3OyEQvF2= MnvKV2FPT0WU
SCC-9 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV24fI4yUUN3ME2zOk44OTR4IN88US=> MmSyV2FPT0WU
SH-4 M{fY[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTN4LkezJO69VQ>? M4LZenNCVkeHUh?=
HCC-1954 M{XqSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3KTWM2OD1|Nz6yO|I6KM7:TR?= NUL1ZYM2W0GQR1XS
BALL-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTzN|lKSzVyPUO3MlU{OTZizszN MXHTRW5ITVJ?
BE-13 M4TGTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrxTWM2OD1|Nz63NFE5KM7:TR?= MnznV2FPT0WU
COLO-678 M2jJPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e5bGlEPTB;M{euPVQ{PyEQvF2= M{e5[3NCVkeHUh?=
SK-MEL-3 MljoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rUeGlEPTB;M{iuNlM6PyEQvF2= NYSzS4I1W0GQR1XS
OAW-28 M1TlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjRSWZKSzVyPUO4MlY{QSEQvF2= M2rjPXNCVkeHUh?=
CAMA-1 NH3aS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorKTWM2OD1|OD65OlkyKM7:TR?= NFPO[IVUSU6JRWK=
C2BBe1 NXXQZWhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvOSI9FUUN3ME2zPU45OThizszN NHHGb3ZUSU6JRWK=
A3-KAW NHryNHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjlcotOUUN3ME20NE4{PjZzIN88US=> NWi2[lVzW0GQR1XS
SK-MEL-24 M1HXR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHjXZVoUUN3ME20NE42QTNzIN88US=> NV7R[WV5W0GQR1XS
KYSE-140 NXfQ[HhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTRyLkexOlUh|ryP MVTTRW5ITVJ?
MOLT-16 NX\ZV41QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\DTWM2OD12MT6xOVM3KM7:TR?= NVH3TIt2W0GQR1XS
CFPAC-1 NIT4bnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLUbG9CUUN3ME20Nk42OjFzIN88US=> NHH2bWVUSU6JRWK=
NB14 M3zD[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS1TWM2OD12Mj63NFI4KM7:TR?= MVjTRW5ITVJ?
COLO-792 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTR{Lki5OlEh|ryP MYHTRW5ITVJ?
RH-1 M1rKNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LxemlEPTB;NEOuOFg{PiEQvF2= NX3BUmZ5W0GQR1XS
NCI-H522 M4LRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDKPIRKSzVyPUS0MlM2PjhizszN MXjTRW5ITVJ?
Ca-Ski NEG3emNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13rNmlEPTB;NESuPFEyPCEQvF2= MWDTRW5ITVJ?
KGN NFn6WGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[2eWlEPTB;NEiuN|A3OyEQvF2= MV;TRW5ITVJ?
UACC-62 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT6eJNmUUN3ME20PE41ODd{IN88US=> MoTHV2FPT0WU
NCI-H358 NGf6UZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTR7LkOwNVgh|ryP MonVV2FPT0WU
LS-411N MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3HTWM2OD12OT6zNVE5KM7:TR?= Mny3V2FPT0WU
IST-MES1 NHGwUoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXWVWZIUUN3ME20PU42PjJ3IN88US=> MmHnV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]
臨床試験 A Phase I study of GDC-0941 in patients with locally advanced or metastatic solid tumors, Non-Hodgkin's lymphoma, or multiple myeloma (MM) (expansion stage only) for which standard therapy either does not exist or has proven ineffective or intolerable is
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Scintillation proximity assay Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.

細胞アッセイ: [2]

細胞株 SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 48 and 72 hours
実験の流れ Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.

動物実験: [2]

動物モデル NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
製剤 Dissolved in 10% DMSO, 5% Tween 20, 85% water
投薬量 ~150 mg/kg/day
投与方法 Oral gavage

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Pictilisib (GDC-0941) SDF
分子量 513.64
化学式

C23H27N7O3S2

CAS No. 957054-30-7
保管 3年-20℃
2年-80℃in solvent
別名 RG7321
溶解度 (25°C) * In vitro DMSO 44 mg/mL (85.66 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine

文献中の引用 (57)

技術サポート&よくある質問(FAQ)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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