Pictilisib (GDC-0941) 化学構造
分子量: 513.64

高品質保証

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カスタマーフィードバック(7)

Quality Control & MSDS

製品説明

  • Compare PI3K Inhibitors
    PI3K製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法
  • Pictilisib (GDC-0941)のメカニズム

製品の説明

生物活性

製品説明 Pictilisib (GDC-0941)は、PI3Kα、PI3Kβ、PI3KδとPI3Kγの強力な阻害剤で、IC50 がそれぞれ 3 nM、 33 nM、 3 nM、75 nMです。
ターゲット PI3Kα PI3Kβ PI3Kδ PI3Kγ
IC50 3 nM 33 nM 3 nM 75 nM [1]
In vitro試験 GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
Sf9 NWTNW4p3U2mwYYPlJGF{e2G7 MYqxJIg> NE[wXVNFVVOR NUXadHlOUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDk[Yx1[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN NWXrO3ptOTh5NUS2OVQ>
Sf9 Moi3T4lv[XOnIFHzd4F6 M4jN[lEhcA>? NGLtXHVFVVOR NF7iPGpKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhUDFyNEetVkBufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? MXGxPFc2PDZ3NB?=
Sf9 MlPaT4lv[XOnIFHzd4F6 Mn7PNUBp M4X0fWROW09? MXzJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgSVU1PS2NIH31eIFvfCCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN MX[xPFc2PDZ3NB?=
Sf9 NHXKN45McW6jc3WgRZN{[Xl? MYexJIg> NHnHSYdFVVOR MnPtTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCzN{DPxE1? Mn3LNVg4PTR4NUS=
Sf9 M1uzOWtqdmG|ZTDBd5NigQ>? MVuxJIg> NH3VZmlFVVOR NV7ZVYNTUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDhcJBp[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[Q>? NWTSU4diOTh5NUS2OVQ>
MDA-MB-361 NWi1bW5YTnWwY4Tpc44hSXO|YYm= M{n0XlIhcA>? MX7EUXNQ M1\4SGlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iTVTBMW1DNTN4MTDj[YxteyC5aYToJHBKUzOFQTDFOVQ2NUtibYX0ZZRqd25id3n0bEBKSzVyIH;mJFAvODJ6IN88US=> MV[xPFc2PDZ3NB?=
PC3 M2\N[GZ2dmO2aX;uJGF{e2G7 NWrpZphWOiCq NWDOWXBbTE2VTx?= NIjhOIhKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDQR|Mh[2WubIOge4l1cCCLQ{WwJI9nKDBwMEO3JO69VQ>? M1HuR|E5PzV2NkW0
U87MG MYfGeY5kfGmxbjDBd5NigQ>? M{fjWVIhcA>? M2jwNGROW09? MULJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCXOEfNS{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yNE[g{txO Moq3NVg4PTR4NUS=
MDA-MB-361 NILn[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fsVVk3KGh? NGn0foNFVVOR NVz5eJJ1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC55MjFOwG0> MnjhNVg4PTR4NUS=
A2780 M3jtfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:1OXFFQTZiaB?= MVnEUXNQ NELHdlRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFGyO|gxKGOnbHzzJJdqfGhiUFnLN2NCKGGwZDDQWGVPKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlE1KM7:TR?= MVOxPFc2PDZ3NB?=
PC3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;sNY9bQTZiaB?= MnP0SG1UVw>? NITGUWdKSzVyPUCuNlgh|ryP NXvneotTOTh5NUS2OVQ>
U87MG NGjybpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXu5OkBp NVzZdWJzTE2VTx?= NIfQPIxKSzVyPUCuPVUh|ryP NUmxVW5TOTh5NUS2OVQ>
Sf9 M{LiWWtqdmG|ZTDBd5NigQ>? MV:zNEBucW5? NGrwPVhFVVOR M2[1WGlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDhcY92dnRib3[gRXRRKGOxboP1cYVlKHerdHigTWM2OCCxZjCwMlA1OiEQvF2= M{[1flIzPTR6M{Sy
RAW 264.7 MWTLbY5ie2ViQYPzZZk> MUG5NEBucW5? NIrRXnZFVVOR M1XVfWlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEGNVDDwbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvOjl6IN88US=> NIrUcoYzOjV2OEO0Ni=>
Sf9 Ml7WT4lv[XOnIFHzd4F6 M1LuO|EhcA>? NX6xbY5OUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2KndHGg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPGPUBk\WyuczD3bZRpKEmFNUCgc4YhOC5yMUeg{txO NFvYWmozOzV2ME[0OS=>
Sf9 NHX6NGlMcW6jc3WgRZN{[Xl? M4rve|EhcA>? MV3Jcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[IVtfGFiZYjwdoV{e2Wm NGTwd3QzOzV2ME[0OS=>
Sf9 MUjLbY5ie2ViQYPzZZk> NHyxToQyKGh? MlToTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4didW2jIHX4dJJme3OnZB?= MnyyNlM2PDB4NEW=
Sf9 MWTLbY5ie2ViQYPzZZk> MVKxJIg> M4Dn[2lvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tidHCqYTDlfJBz\XO|ZXS= MmLaNlM2PDB4NEW=
SKOV3 NEL2R3RMcW6jc3WgRZN{[Xl? M3LjN|Eh|ryP NEnHZYUyKGh? MnG5SG1UVw>? NFLzW49KdmirYnn0bY9vKG:oIGDJN2tidHCqYTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:w Ml;qNlM{PjB|NEi=
MCF7 NFfoR2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jNdVEh|ryP MU[5OkBp MVzEUXNQ NV\ndFJDT0l3ME2wMlA4ODJizszN NULCWHlbOjN|NkCzOFg>
SKOV3 MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWexJO69VQ>? MkjYPVYhcA>? Mn\CSG1UVw>? NVPjPWY1T0l3ME2wMlE1PzZizszN NET0WXEzOzN4MEO0PC=>
PC3 NWjGXJF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC3NkBp M{LFUmROW09? MX;JR|UxRTBwMkig{txO MnT3NlE6QDF5MUS=
MCF7.1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOw[IdRPzJiaB?= NITXeWFFVVOR NYW0T3RFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCKRWKyJIdmdmVid3n0bEBKSzVyIH;mJFAvOjhizszN MWKyNVk5OTdzNB?=
MCF7-neo/Her2 M13uNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUK3NkBp NYX6bIZSTE2VTx?= NHL5UVNKSzVyPUCuNlkh|ryP NHjJWlIzOzZ4MkmwNy=>
MCF7-neo/Her2 NYjwNIoxU2mwYYPlJGF{e2G7 NUfpcXdZUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIFHLWEBxcG:|cHjvdplt[XSrb36gZZQhWzR5MzD3bZRpKEmFNUCgc4YhOC5yMEeg{txO MVuyN|Y3OjlyMx?=
PC3 NYq5e3czT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV63NkBp M3j5XGROW09? NVPtSXhJTUN3ME2wMlM1KM7:TR?= NWXWdpBROjF7OEW2N|k>
MCF7.1 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP2NVZ4PzJiaB?= M1XOXWROW09? NIDKNmNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKFCLM1vhcJBp[SCvdYThcpQhf2m2aDDFR|UxKG:oIECuN|kh|ryP MVmyNVk5PTZ|OR?=
PC3 MoPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfRVoRrPzJiaB?= NIfVXGlFVVOR M1\6dmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHTl[olkcWWwdDDpckBRXEWQIIfpeIghUUN3MDDv[kAxNjN7IN88US=> M4PxVFIxODVyNk[5
MCF7.1 MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV:3NkBp M3zlbGROW09? M1jBO2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFnDOVAhd2ZiMD6zOEDPxE1? NFXydGszODB3ME[2PS=>
MCF7.1 M3Lse2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;iXIg4OiCq Mk\nSWM2OD1yLkeyJO69VQ>? NVfpU3JCOjB|NE[2OVY>
NCI-H1975 MkXSR5l1d3SxeHnjJGF{e2G7 M1G0fVczKGh? NXnPVmJqUUN3ME2wMlI4KM7:TR?= Mke0NlMxPTl3NEW=
H460 MV3DfZRwfG:6aXOgRZN{[Xl? NXnRNYFXPzJiaB?= MXjJR|UxRTBwOEeg{txO M1LGXlI{ODV7NUS1
HT-29 MUPDfZRwfG:6aXOgRZN{[Xl? MkjqO|IhcA>? NVPIdnpkUUN3ME2wMlY3KM7:TR?= MlTPNlMxPTl3NEW=
HepG2 MX3DfZRwfG:6aXOgRZN{[Xl? MlHqO|IhcA>? NFXTS3BKSzVyPUGg{txO M1fmSVI{ODV7NUS1
SGC7901 NXXhXFRTS3m2b4TvfIlkKEG|c3H5 M3PmW|czKGh? NV;qWpE1UUN3ME2xMlgh|ryP MWSyN|A2QTV2NR?=
NCI-H226 MUHDfZRwfG:6aXOgRZN{[Xl? MmXyO|IhcA>? NWHtPGpHUUN3ME2yMlkh|ryP MX[yN|A2QTV2NR?=
A549 Ml\VR5l1d3SxeHnjJGF{e2G7 M4\aW|czKGh? NViyUmJLUUN3ME22Mlkh|ryP M{iyTVI{ODV7NUS1
U87MG MWjDfZRwfG:6aXOgRZN{[Xl? Mkf3O|IhcA>? NU[3WGhlUUN3ME23Mlc4KM7:TR?= MojGNlMxPTl3NEW=
HBC4 NVrFVoNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\ONYdPdG:pR1m1NF0uPi5yMzDN MXeyNlM{PjJ2Nh?=
BSY1 NUDac2FxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTWV2ttd2eJSUWwQU03NjlyIF2= MUGyNlM{PjJ2Nh?=
HBC5 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTsc4dIUTVyPT22MlYxKE1? M{jqcVIzOzN4MkS2
MCF7 NYHBT5lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvrWoNtd2eJSUWwQU04NjN|IF2= MX6yNlM{PjJ2Nh?=
MDA-MB-231 NXnkTVU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS5cI9oT0l3ME2tOU41PiCP MUKyNlM{PjJ2Nh?=
U251 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLzTohtd2eJSUWwQU02NjVyIF2= M3jqNFIzOzN4MkS2
SF268 NXvESGpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;sc4dIUTVyPT21MlM6KE1? M2[0UVIzOzN4MkS2
SF295 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fxTYxw\0eLNUC9MVYvOzdiTR?= M2TGWFIzOzN4MkS2
SF539 NHjVNolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFriUpltd2eJSUWwQU03NjVyIF2= MXqyNlM{PjJ2Nh?=
SNB75 M1vRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHmcI9oT0l3ME2tO{4yOCCP MnPuNlI{OzZ{NE[=
SNB78 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nTfYxw\0eLNUC9MVYvPTJiTR?= Mm\4NlI{OzZ{NE[=
HCC2998 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjPVFgzdG:pR1m1NF0uPi5{OTDN MkPBNlI{OzZ{NE[=
KM12 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHUbox6dG:pR1m1NF0uPS55NjDN MXOyNlM{PjJ2Nh?=
HT-29 NIPDVFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\sc4dIUTVyPT22MlMxKE1? MWCyNlM{PjJ2Nh?=
HCT15 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjNcI9oT0l3ME2tOk4yOiCP NYXpfFU3OjJ|M{[yOFY>
HCT116 NUH0S242T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomxcI9oT0l3ME2tOU45PyCP MkfTNlI{OzZ{NE[=
NCI-H23 NVjZeFdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvsc4dIUTVyPT21Mlc{KE1? NX3kZpJlOjJ|M{[yOFY>
NCI-H226 MlrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrsc4dIUTVyPT22MlIyKE1? NHvFV3IzOjN|NkK0Oi=>
NCI-H522 NX\kU5FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7sc4dIUTVyPT22MlU5KE1? NUP4b4dZOjJ|M{[yOFY>
NCI-H483 M4TZTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\sc4dIUTVyPT22MlU3KE1? MXeyNlM{PjJ2Nh?=
A549 NIDrdHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPtcI9oT0l3ME2tOk4yPSCP NUfYW5VxOjJ|M{[yOFY>
DMS273 NUjBZYd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nhOYxw\0eLNUC9MVYvPDNiTR?= NXy4TZF1OjJ|M{[yOFY>
DMS114 MkewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrkR2Rtd2eJSUWwQU02Njl{IF2= MlvUNlI{OzZ{NE[=
LOXIMVI MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\tOYhtd2eJSUWwQU03NjJ7IF2= M2nVcFIzOzN4MkS2
OVCAR3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP1cI9oT0l3ME2tOk44OSCP MoTSNlI{OzZ{NE[=
OVCAR4 MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLsc4dIUTVyPT21Mlc3KE1? MmjZNlI{OzZ{NE[=
OVCAR5 NWXPUHVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XPRoxw\0eLNUC9MVYvOjZiTR?= MkLoNlI{OzZ{NE[=
OVCAR8 NYGwd5g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rI[Ixw\0eLNUC9MVUvPzNiTR?= M3Lp[VIzOzN4MkS2
SKOV3 NWXaNJp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLMWHJtd2eJSUWwQU03NjV{IF2= MWqyNlM{PjJ2Nh?=
RXF631L NVvVUVFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXxXoptd2eJSUWwQU03Njh6IF2= M3[0eVIzOzN4MkS2
ACHN NXL0UG9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7sc4dIUTVyPT22MlA4KE1? NYfrTIhYOjJ|M{[yOFY>
St-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz2cI9oT0l3ME2tOU42PiCP MmDvNlI{OzZ{NE[=
MKN1 M1W1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPsc4dIUTVyPT23MlA5KE1? M2jDVlIzOzN4MkS2
MKN7 Mn71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\sc4dIUTVyPT22MlUxKE1? NXTtPIJMOjJ|M{[yOFY>
MKN28 NWDMPJZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX1UYZtd2eJSUWwQU02NjV{IF2= NInBVWIzOjN|NkK0Oi=>
MKN45 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjkZWRtd2eJSUWwQU03NjV3IF2= NFPkfmczOjN|NkK0Oi=>
MKN74 M2D5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfmcI9oT0l3ME2tOk4xOiCP NWDpV5NCOjJ|M{[yOFY>
DU145 MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLoZppUdG:pR1m1NF0uPS56NTDN NInWU5czOjN|NkK0Oi=>
PC3 NEfMeYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj0cI9oT0l3ME2tOk43PiCP MUiyNlM{PjJ2Nh?=
ES5 M1zmRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTVyLkKxJI5O NYftV2lqW0GQR1XS
HH NWrxUYVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjDToE6UUN3ME2xNVEvODhibl2= MYfTRW5ITVJ?
MHH-PREB-1 NGnlN3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTFzND6zJI5O MUDTRW5ITVJ?
NCI-H1770 MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITOUZZKSzVyPUGyN{45PiCwTR?= NWfweG1zW0GQR1XS
HuO9 MoXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfLTWM2OD1{ME[uNFIhdk1? NXWzSI9xW0GQR1XS
HAL-01 M36wNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDMcnNRUUN3ME2yNFYvPzNibl2= NYnJPJl4W0GQR1XS
NOS-1 NXjvZ216T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nzbWlEPTB;MkGxMlgzKG6P NWfmcohZW0GQR1XS
HGC-27 NIrnfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJzMj61O{BvVQ>? NWfm[45IW0GQR1XS
NB69 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PjWmlEPTB;MkS1MlI4KG6P MorNV2FPT0WU
RS4-11 MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13TWGlEPTB;Mk[xMlc3KG6P NGLNV5BUSU6JRWK=
DOK NWD3do8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fKfGlEPTB;M{CxMlchdk1? M{X3SHNCVkeHUh?=
LB2241-RCC NGDKZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3NVXVKSzVyPUOwN{45PCCwTR?= M{PxWXNCVkeHUh?=
NCI-H1623 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7CXJNjUUN3ME2zNFQvODhibl2= M4DzfHNCVkeHUh?=
YH-13 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3jTWM2OD1|MESuN|Ihdk1? MXnTRW5ITVJ?
BPH-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLlTWM2OD1|MUSgcm0> MX;TRW5ITVJ?
AN3-CA M3TFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7UUm5KSzVyPUO0NE4{PyCwTR?= MmP5V2FPT0WU
ES7 M1Hq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Xje2lEPTB;M{SxMlk6KG6P MnLVV2FPT0WU
MDA-MB-175-VII MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi0OHhKSzVyPUO1Nk46OiCwTR?= NFv0WGVUSU6JRWK=
GAMG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrOTWM2OD1|N{CuPFUhdk1? MXjTRW5ITVJ?
CHL-1 M2DNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTN5OD62OUBvVQ>? M13jbXNCVkeHUh?=
NB7 NFzrdldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DIWWlEPTB;M{i5Mlg{KG6P MoHsV2FPT0WU
MFE-280 Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXJd3dNUUN3ME20NVgvOiCwTR?= MXvTRW5ITVJ?
HL-60 NGC3NnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTR{NT63OUBvVQ>? NXqwcGhHW0GQR1XS
GCIY M1PqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTR|Mz64JI5O NXHIOZNlW0GQR1XS
MDA-MB-361 M3zXS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTZVWxHUUN3ME20N|kvOTNibl2= MmjvV2FPT0WU
LXF-289 NIm4PFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\QbGlEPTB;NES4MlI4KG6P MWXTRW5ITVJ?
NBsusSR MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTR6OD64OUBvVQ>? M{K2PHNCVkeHUh?=
KU-19-19 Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLaTWM2OD13MU[uNFchdk1? M3znfHNCVkeHUh?=
A204 Mmf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTV{Mj6zN{BvVQ>? NX33dlhxW0GQR1XS
LB1047-RCC Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjFUIpnUUN3ME21NlIvQTNibl2= MV3TRW5ITVJ?
COLO-684 MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfoVoNQUUN3ME21NlMvOTFibl2= MWDTRW5ITVJ?
PA-1 M1XuUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[0W2RKSzVyPUWzNk41OSCwTR?= NVz1[plDW0GQR1XS
MG-63 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnZUIxNUUN3ME21OFEvOTFibl2= NWf1UFg2W0GQR1XS
BHT-101 NEn3dm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVSzO2pOUUN3ME21OFQvQTRibl2= NHTyO|ZUSU6JRWK=
NKM-1 NGfMSWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrjTWM2OD13OUOuNFkhdk1? NXPkTVlyW0GQR1XS
T47D Ml3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULtSm1EUUN3ME21PVcvPTZibl2= NXGxeolCW0GQR1XS
MOLT-4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XHcmlEPTB;NkKzMlYzKG6P NEnlUW1USU6JRWK=
IGROV-1 M4LVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfMRVBKSzVyPU[zOE4{OSCwTR?= NITZbYtUSU6JRWK=
ES4 NFTNd5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnLe4pKSzVyPU[zPU42PCCwTR?= NVLmd3ZmW0GQR1XS
HuO-3N1 NILrO2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m4d2lEPTB;NkSyMlM5KG6P NH3BPFdUSU6JRWK=
NEC8 MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTZ3Mz61O{BvVQ>? NWDLOnlrW0GQR1XS
HO-1-N-1 Mo\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTVTWM2OD14NUmuNVchdk1? NY\Ze5dLW0GQR1XS
EPCL-272H MmOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInFVJVKSzVyPU[4O{4zOSCwTR?= MVHTRW5ITVJ?
D-263MG M1n5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTdzOD6xJI5O M3zCdXNCVkeHUh?=
MV-4-11 NF3POGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInL[FJKSzVyPUeyOE4{OSCwTR?= NVv3PW9wW0GQR1XS
SK-NEP-1 MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfxVZFKSzVyPUeyOU46PCCwTR?= MnfwV2FPT0WU
SW872 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvhTWM2OD15MkeuPFkhdk1? NYXIcWJ[W0GQR1XS
P30-OHK NF;QRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfV[lJKSzVyPUezNE44OSCwTR?= MnnsV2FPT0WU
OMC-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLZTWM2OD15NUGuNFkhdk1? M1TPTnNCVkeHUh?=
LoVo NInscllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTd5Nz65JI5O MXnTRW5ITVJ?
LNCaP-Clone-FGC M3;yb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmOwTWM2OD15OU[uN|Qhdk1? M{\oO3NCVkeHUh?=
L-363 NXjJWIlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\wVFZXUUN3ME23PVgvPDJibl2= NVTyWoxYW0GQR1XS
ES8 M1z5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq2TWM2OD16MUCuOVIhdk1? MVvTRW5ITVJ?
697 NIfMeFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr4e3hSUUN3ME24N|EvPTVibl2= NICydlZUSU6JRWK=
HSC-3 M4rLWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HO[GlEPTB;OEO5MlU1KG6P M2LLUHNCVkeHUh?=
H4 NHvFU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPVNGxKSzVyPUi1NE45PSCwTR?= Mn7EV2FPT0WU
QIMR-WIL MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\qcWlEPTB;OE[1MlIhdk1? MnraV2FPT0WU
OAW-42 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XFfWlEPTB;OEeyMlE6KG6P Ml\RV2FPT0WU
MCF7 NY[2ZYVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTh7OD61PUBvVQ>? M1HPS3NCVkeHUh?=
SCC-25 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHFdGRKSzVyPUmxOE4yQSCwTR?= M2LkO3NCVkeHUh?=
NCI-H1563 M3\FeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHvTWM2OD17MUWuPVkhdk1? M1m4d3NCVkeHUh?=
OVCAR-5 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrJTWM2OD17NECuNVchdk1? Mmn3V2FPT0WU
HDLM-2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zFNGlEPTB;OUS5MlIhdk1? NV7GXmRUW0GQR1XS
NB5 NVnGdYNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfRPWJzUUN3ME25OVYvPiCwTR?= M2fLcnNCVkeHUh?=
NCI-H292 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml2zTWM2OD17N{SuN|Ihdk1? M2DhZ3NCVkeHUh?=
A101D NEmxcG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPFTWM2OD17OUCuNVkhdk1? NETnXZZUSU6JRWK=
NCI-H1648 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvhTWM2OD17OUiuOVEhdk1? MmLoV2FPT0WU
EKVX Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVji[pozUUN3ME2xMlAyOjlizszN MoPFV2FPT0WU
SW1710 NV:5Z3Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XTbmlEPTB;MT6wOFI{OyEQvF2= NWDHOW1OW0GQR1XS
WM-115 M4LuSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jCW2lEPTB;MT6wOlY2PiEQvF2= NIjtSY9USU6JRWK=
CAL-54 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK0TWM2OD1zLkC3NFgyKM7:TR?= NXfq[XVDW0GQR1XS
TGBC24TKB M3HL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULiTFhsUUN3ME2xMlA5ODR3IN88US=> NF7mZotUSU6JRWK=
NCI-H520 NGHOWWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\ETWM2OD1zLkC4PVY4KM7:TR?= MnOwV2FPT0WU
D-423MG NIrhWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTFwMEm5OlIh|ryP M1\JcXNCVkeHUh?=
BFTC-905 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvS[mxKSzVyPUGuNVM1PDlizszN NILkeYNUSU6JRWK=
HT M2e3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXIOYNKSzVyPUGuNVM1PzhizszN MVPTRW5ITVJ?
CTB-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X1dWlEPTB;MT6xOFI6OyEQvF2= MYPTRW5ITVJ?
Hs-578-T MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P6SGlEPTB;MT6xPVU3PSEQvF2= MlnpV2FPT0WU
HuH-7 NIDNXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7B[VVwUUN3ME2xMlIxQTR7IN88US=> MYrTRW5ITVJ?
LB996-RCC NFm4WW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfIcVJrUUN3ME2xMlIzOTd5IN88US=> MoL2V2FPT0WU
KYSE-270 NXPmXXRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXjXFVKSzVyPUGuNlk4OzRizszN NXvV[nBoW0GQR1XS
A4-Fuk MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzYfW5tUUN3ME2xMlI6QTl|IN88US=> M{W5eHNCVkeHUh?=
A498 M1q5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLMWGdUUUN3ME2xMlMxPDd2IN88US=> NGnodZVUSU6JRWK=
SK-MEL-1 NHjKT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDP[25KSzVyPUGuN|A3PzlizszN M2e2dHNCVkeHUh?=
AU565 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7jdZhKSzVyPUGuN|E5PjNizszN NVHxbXlwW0GQR1XS
Saos-2 M4rER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTFwM{OyNFUh|ryP M1PoRXNCVkeHUh?=
A549 MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLUTWM2OD1zLkO5PVch|ryP NV7QVY5NW0GQR1XS
BFTC-909 NHTJbFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n1WGlEPTB;MT60N|MxPSEQvF2= MXrTRW5ITVJ?
MDA-MB-415 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\hZlY{UUN3ME2xMlQ5Pjl{IN88US=> NELYXGVUSU6JRWK=
639-V MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwNUCyOFUh|ryP NWKyRW5bW0GQR1XS
A704 NHq2T5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17NWGlEPTB;MT61NFc5PSEQvF2= NIrne5lUSU6JRWK=
PANC-03-27 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTFwNUG0NFgh|ryP MlrnV2FPT0WU
SK-MEL-28 MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTFwNU[wPFUh|ryP MXTTRW5ITVJ?
Ramos-2G6-4C10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLMcFhKSzVyPUGuOlA4PDZizszN MWnTRW5ITVJ?
HuP-T4 M3roVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L2XWlEPTB;MT62NFc4QCEQvF2= M3fpc3NCVkeHUh?=
VA-ES-BJ MljBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnFVI5sUUN3ME2xMlYyOjdizszN NYPBboRHW0GQR1XS
EFM-19 NG[xT|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfRb2JIUUN3ME2xMlYyQDFizszN MmjmV2FPT0WU
G-401 NEPxdnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrFTWM2OD1zLk[yNVY1KM7:TR?= MXfTRW5ITVJ?
D-566MG NULVOFdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLjTWM2OD1zLk[yOVMh|ryP Mon5V2FPT0WU
JVM-3 NUHmNFdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILWT5FKSzVyPUGuOlQ5PzVizszN M3\3eHNCVkeHUh?=
TK10 MnLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXU[nNwUUN3ME2xMlY4ODh|IN88US=> MX7TRW5ITVJ?
BT-20 M1TCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFwNki5NFIh|ryP MW\TRW5ITVJ?
EGI-1 MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H3Z2lEPTB;MT64OFcxOSEQvF2= MWDTRW5ITVJ?
EW-16 NXuxSHk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG5UW1KSzVyPUGuPFUyQDJizszN MUXTRW5ITVJ?
NCI-H2228 M{HmTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPqXIhKSzVyPUGuPFUzODNizszN NVrFWGhlW0GQR1XS
BB49-HNC M4TPXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTHTWM2OD1zLki4OlkzKM7:TR?= MVrTRW5ITVJ?
G-402 M{DQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwOEm3PVch|ryP M4Gx[nNCVkeHUh?=
NCI-H526 NU\aOmdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTFwOUGzPUDPxE1? MV;TRW5ITVJ?
ME-180 M4TGU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfFTWM2OD1zLkmzOFc4KM7:TR?= MV7TRW5ITVJ?
PFSK-1 NWn3OVl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\ETWM2OD1zLkm0OFU5KM7:TR?= NFe4d2tUSU6JRWK=
TYK-nu Mof5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fTVGlEPTB;MT65OVgzOyEQvF2= NEfDeWRUSU6JRWK=
HOS NGPHe5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LCd2lEPTB;MT65O|k1QCEQvF2= M3;4VHNCVkeHUh?=
T98G MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTFwOUmwNFYh|ryP NGH6cXlUSU6JRWK=
SK-MES-1 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPTSoNKSzVyPUKuNFE{OzJizszN NUXIflhQW0GQR1XS
SNB75 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Lk[GlEPTB;Mj6wNVU1OSEQvF2= MULTRW5ITVJ?
LAMA-84 NGW4S25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvTTWM2OD1{LkCyOlg6KM7:TR?= NYq1elF7W0GQR1XS
CAL-39 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwMEOyPEDPxE1? M3TM[nNCVkeHUh?=
LOXIMVI NUfUeHJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfsdolZUUN3ME2yMlA1ODh2IN88US=> M4L1V3NCVkeHUh?=
NH-12 MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVu4PYJyUUN3ME2yMlA2PDJ2IN88US=> M1jST3NCVkeHUh?=
NCI-H1048 NVLwdJNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJwMUC1NkDPxE1? NGewe5BUSU6JRWK=
KS-1 NIK1Z2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHkTWM2OD1{LkGxNFAyKM7:TR?= M3\1bnNCVkeHUh?=
NCI-N87 M2TjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XSRWlEPTB;Mj6xN|M5PCEQvF2= NG\XXXlUSU6JRWK=
CHP-212 NIDReWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXTTWM2OD1{LkG4OFQzKM7:TR?= M{TIbnNCVkeHUh?=
HCC1419 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LyWmlEPTB;Mj6yNVEyPSEQvF2= NHW4SFhUSU6JRWK=
ES1 NVPQT5NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJwMkGzNlYh|ryP Mn;GV2FPT0WU
NCI-H2030 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\Q[mlEPTB;Mj6yOFEzOyEQvF2= MWrTRW5ITVJ?
EW-22 MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC2OY5KSzVyPUKuNlUxPjdizszN M{fUZnNCVkeHUh?=
A431 M3;kVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW2TWM2OD1{LkK3N|U1KM7:TR?= M3KxWHNCVkeHUh?=
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Daoy MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTdwOUSzNlEh|ryP MVfTRW5ITVJ?
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GB-1 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;aZ2FKSzVyPUiuNFY2PjVizszN NHLjdIlUSU6JRWK=
SJRH30 MlnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLKRmJKSzVyPUiuNVU5PzhizszN NE\WTG5USU6JRWK=
NCI-H2291 M3vhbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y5XWlEPTB;OD6yPVE5PyEQvF2= NWPRRm1bW0GQR1XS
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NCI-H596 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[1R2lEPTB;OD6zNVQ2OyEQvF2= NUTXN4V2W0GQR1XS
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RH-18 NH;XW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRThwM{WwOFYh|ryP NX;VUlhlW0GQR1XS
SW48 NUDuRVZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\s[o1wUUN3ME24MlU6PDV|IN88US=> NXT4UYNVW0GQR1XS
RD NUHXSmdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPXTWM2OD16LkW5N|kyKM7:TR?= MmTBV2FPT0WU
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ES6 MmOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrscGFKSzVyPUiuO|MyOTlizszN NWradWpYW0GQR1XS
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KINGS-1 NXfSc3B2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e4R2lEPTB;OD65Nlk{QCEQvF2= M{X5dHNCVkeHUh?=
HLE MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\sUHVKSzVyPUiuPVM4QDVizszN MX3TRW5ITVJ?
MHH-NB-11 MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTlwMEG4N|kh|ryP NFm1ZVNUSU6JRWK=
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MN-60 M3jxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILMRY9KSzVyPUmuNlQ2PDJizszN NU[xdmFoW0GQR1XS
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NCI-H446 NFrmd4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW2PGdKSzVyPUmuN|YyKM7:TR?= MX3TRW5ITVJ?
C-33-A NGfWcmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD2TWM2OD17LkSzPVg5KM7:TR?= M1XneXNCVkeHUh?=
RXF393 M4Tkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHyTWM2OD17LkS3NFAzKM7:TR?= MWrTRW5ITVJ?
CGTH-W-1 MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvaR2JKSzVyPUmuOFk{QDRizszN NGrQ[|VUSU6JRWK=
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SN12C MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnIXpV5UUN3ME25MlY2OzN6IN88US=> NH3vOZhUSU6JRWK=
KLE M1;WW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH5fFJKSzVyPUmuO|AxODlizszN MlS4V2FPT0WU
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KYSE-70 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDaTWM2OD17Lki4NFEyKM7:TR?= NYDyRolHW0GQR1XS
D-247MG NHfQbVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[4b2F1UUN3ME2xNE4xPTZ6IN88US=> MoDDV2FPT0WU
MPP-89 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PBUWlEPTB;MUCuNFk1PiEQvF2= NGrZdnhUSU6JRWK=
RVH-421 M{fHNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrRTWM2OD1zMD6xOVA2KM7:TR?= MYLTRW5ITVJ?
NCI-H460 NIrVd2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPHOIhDUUN3ME2xNE4zQDB4IN88US=> NHXoNXJUSU6JRWK=
NOMO-1 NFfOdGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv2UnhjUUN3ME2xNE4{PTN{IN88US=> Mn7CV2FPT0WU
DEL NInZWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFyLkO3PVQh|ryP NXXvdJhXW0GQR1XS
HT55 NIrqPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1L3b2lEPTB;MUCuOlIxPSEQvF2= NWSxS2RoW0GQR1XS
MC116 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPRTWM2OD1zMD62OlU2KM7:TR?= M2LhOXNCVkeHUh?=
BB30-HNC NVr5VHA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPzXppKSzVyPUGwMlY3QSEQvF2= NEHrNFhUSU6JRWK=
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U-118-MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnCc|BZUUN3ME2xNE46QDl4IN88US=> M1i1XXNCVkeHUh?=
MSTO-211H M2\RN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LJb2lEPTB;MUGuNFcyPiEQvF2= NX;X[YptW0GQR1XS
SW837 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTFzLkC5OFkh|ryP MkD0V2FPT0WU
HuCCT1 MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\DPGlEPTB;MUGuNVI5OSEQvF2= Moe4V2FPT0WU
RCC10RGB MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFzLkGzOUDPxE1? MlnVV2FPT0WU
NMC-G1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPW[IhKSzVyPUGxMlE1QTNizszN M4exVHNCVkeHUh?=
NCI-H650 MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm5SYtKSzVyPUGxMlM4QTRizszN M2nPbnNCVkeHUh?=
HEC-1 NVX3TlVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPrTWM2OD1zMT60N|I5KM7:TR?= Mm[0V2FPT0WU
DU-4475 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnmNJlKSzVyPUGxMlc{QTNizszN M3f1[nNCVkeHUh?=
DSH1 M1nt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTFzLke2NFYh|ryP M3TmeHNCVkeHUh?=
HCC1569 MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV33UJlkUUN3ME2xNU44Pjd6IN88US=> Moi2V2FPT0WU
HCC1187 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fmOmlEPTB;MUGuPFU5QCEQvF2= MmW3V2FPT0WU
EW-11 NFX6WlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrkTWM2OD1zMT65OFc1KM7:TR?= NX;rS5NYW0GQR1XS
LB2518-MEL NUHBOmNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTF{LkC1PUDPxE1? M4XZfHNCVkeHUh?=
KALS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrrPWVKSzVyPUGyMlg2PTNizszN NFnFcFNUSU6JRWK=
8505C MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\u[WlEPTB;MUKuPFg2KM7:TR?= NETrSWZUSU6JRWK=
SK-N-DZ NUK4OWxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlntTWM2OD1zMz6wOFU{KM7:TR?= NWjWdYhEW0GQR1XS
CHP-134 MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTF|LkGxOVgh|ryP MVrTRW5ITVJ?
HCE-T MnPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rtb2lEPTB;MUOuNlM3PCEQvF2= NUPJbFVwW0GQR1XS
LB-831-BLC NGfHe|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33KRWlEPTB;MUOuOlI1PiEQvF2= NFLvWJNUSU6JRWK=
OVCAR-4 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm4TWM2OD1zMz62OVI1KM7:TR?= NHf5TohUSU6JRWK=
SW756 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjEfYR6UUN3ME2xN{44OjR4IN88US=> NXHmbpQ6W0GQR1XS
OCUB-M MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTF|LkixOVYh|ryP NFjnU4RUSU6JRWK=
SW982 NWC4OlU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mny4TWM2OD1zMz64Nlc3KM7:TR?= MU\TRW5ITVJ?
DB NYLJOHpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTF|LkizPFQh|ryP NFfwTHpUSU6JRWK=
H-EMC-SS MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7uTWM2OD1zMz65NVM6KM7:TR?= MkjGV2FPT0WU
VMRC-RCZ MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1uzR2lEPTB;MUSuNFAyPSEQvF2= M{PwdHNCVkeHUh?=
CAKI-1 NVrSbJdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\UbWlEPTB;MUSuNFE{OiEQvF2= NEDoR2lUSU6JRWK=
GI-1 Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTpWnVCUUN3ME2xOE4xPjV6IN88US=> MlviV2FPT0WU
Ca9-22 Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzNT5RKSzVyPUG0MlYxPTRizszN MXvTRW5ITVJ?
TE-5 Mn\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrOVHpKSzVyPUG0MlczODhizszN MkLrV2FPT0WU
EFO-27 NXL4[IUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrwTWM2OD1zND63OlIzKM7:TR?= Ml;jV2FPT0WU
CAL-72 NGraN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC4Z5hKSzVyPUG0Mlc4QDNizszN NWTaW4lTW0GQR1XS
GP5d NIDiO3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPwTWM2OD1zNT6wOFc1KM7:TR?= MX3TRW5ITVJ?
CAS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C2T2lEPTB;MUWuNFY3KM7:TR?= NX;zPZRFW0GQR1XS
A2058 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\IOFhKSzVyPUG1MlU3OzhizszN NVHzV3FlW0GQR1XS
PANC-08-13 NHrFVnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTF3Lk[4OVkh|ryP MnzKV2FPT0WU
Detroit562 M1Xidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTF3LkmxN|kh|ryP NYnhWZJ[W0GQR1XS
PANC-10-05 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvUcW9KSzVyPUG2MlA5OjFizszN NXLhRYxRW0GQR1XS
KOSC-2 NFrwR5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jqRWlEPTB;MU[uNVEzPSEQvF2= NXjNRZMzW0GQR1XS
GT3TKB M4nWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHmflNKSzVyPUG2MlE6QDFizszN MoD6V2FPT0WU
KM-H2 NWq1VG5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Pr[GlEPTB;MU[uN|Y1PiEQvF2= MWXTRW5ITVJ?
LB771-HNC M3TXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTMTWM2OD1zNj60OFIzKM7:TR?= NH\wPXNUSU6JRWK=
SF268 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7oTWM2OD1zNj60OVIh|ryP MXXTRW5ITVJ?
OE19 NILRNYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrqfY9KSzVyPUG2MlUzPCEQvF2= NVPrS4pjW0GQR1XS
MLMA MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTF4LkW1O|Eh|ryP M33JO3NCVkeHUh?=
MDA-MB-231 NFHKboxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILKe3lKSzVyPUG2MlcyOzZizszN M4DrOXNCVkeHUh?=
TGW NE\HUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvHeG9KSzVyPUG2MlgyODJizszN NYPGSXByW0GQR1XS
MDA-MB-453 NWHjVZBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\TTWM2OD1zNz6wNFA{KM7:TR?= M2HBNnNCVkeHUh?=
SNU-C2B MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojETWM2OD1zNz6wNlM4KM7:TR?= M{nH[nNCVkeHUh?=
A427 M3\qcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLDTWM2OD1zNz6yN|M1KM7:TR?= M4nYd3NCVkeHUh?=
SK-MEL-2 NV\NNHRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\ab2lKSzVyPUG3MlMzOTNizszN NUfmSlNGW0GQR1XS
KURAMOCHI MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHuc49NUUN3ME2xO{4{QDl5IN88US=> MUDTRW5ITVJ?
IST-MEL1 NHL6UG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PodWlEPTB;MUeuPVE5OiEQvF2= NHXrXmZUSU6JRWK=
NCI-H1793 NUTDfJliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnXVWo6UUN3ME2xPE4yPThzIN88US=> NYDwbW01W0GQR1XS
HCC1395 MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknFTWM2OD1zOD61OlEyKM7:TR?= M3rpSnNCVkeHUh?=
NUGC-3 NEL0XpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jHdmlEPTB;MUiuOlU5PCEQvF2= M1WyXHNCVkeHUh?=
BB65-RCC NI\RdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF6Lk[2PUDPxE1? M1L1bnNCVkeHUh?=
RMG-I NW\LNGxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfq[GxKSzVyPUG4Mlc{QDJizszN NFrMWHFUSU6JRWK=
LS-513 MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LJSmlEPTB;MUiuPVIzQCEQvF2= MWnTRW5ITVJ?
MFM-223 M2S1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mln6TWM2OD1zOT6wO|E3KM7:TR?= NHvYd5lUSU6JRWK=
NCI-H727 NWHjcWhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nHbmlEPTB;MUmuN|I6PSEQvF2= MmnhV2FPT0WU
KP-4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzUNnNWUUN3ME2xPU45PTNzIN88US=> Mnm4V2FPT0WU
NB13 NHjUXWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInScoRKSzVyPUG5Mlg5OzlizszN M33sRXNCVkeHUh?=
UACC-893 NUH4SVZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nzcWlEPTB;MUmuPVc2PyEQvF2= MnPjV2FPT0WU
HT-1197 MlTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTvTWM2OD1{MD6yPVU5KM7:TR?= NELBc2FUSU6JRWK=
NCI-H2029 NIrubFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfzb|BYUUN3ME2yNE4{OjZ4IN88US=> NEHrdm9USU6JRWK=
GI-ME-N MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYWyPJp6UUN3ME2yNE4{Ozd|IN88US=> MkHnV2FPT0WU
OVCAR-3 M1PVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJyLkW4NlIh|ryP MWnTRW5ITVJ?
HD-MY-Z MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYqxZ5hMUUN3ME2yNU4{Pjl4IN88US=> NV\jRlJXW0GQR1XS
NTERA-S-cl-D1 M13RTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i4bGlEPTB;MkGuOlczOiEQvF2= NHS4SmpUSU6JRWK=
SCH M1HKRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnTTZJUUUN3ME2yNk41QTZizszN NILFbGhUSU6JRWK=
KARPAS-299 NHjncnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DtNmlEPTB;MkOuN|g5PyEQvF2= M2fmcnNCVkeHUh?=
NCI-H1650 NWDQfIFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fHeGlEPTB;MkOuPVI1OSEQvF2= MVzTRW5ITVJ?
ACHN M3nZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJ2LkS2OVYh|ryP NV3LOW5DW0GQR1XS
M059J NFj5R2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DIbWlEPTB;MkSuOVY{PCEQvF2= MWHTRW5ITVJ?
AM-38 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPpTWM2OD1{NT60PFEh|ryP NIPxW4dUSU6JRWK=
KG-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlyxTWM2OD1{NT61OFk1KM7:TR?= NIHKPIRUSU6JRWK=
COLO-824 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv3bVBKSzVyPUK1MlU2QTlizszN NX3R[3E5W0GQR1XS
NCI-H1155 M2jQVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUezXZhiUUN3ME2yOU42QDR5IN88US=> MUjTRW5ITVJ?
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J-RT3-T3-5 NXHQPG4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJ4LkOwNlch|ryP Moj1V2FPT0WU
JEG-3 NWfndHNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLQWGhKSzVyPUK2MlY5ODVizszN M36wPXNCVkeHUh?=
RKO MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJ4Lke2N|Ih|ryP MXzTRW5ITVJ?
CAL-85-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPhem15UUN3ME2yO{4zOTF6IN88US=> M4HOenNCVkeHUh?=
CAL-120 NU\YdHROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTSTWM2OD1{Nz62PVE1KM7:TR?= NITkdWVUSU6JRWK=
NCI-H2452 MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJ5Lke3NVYh|ryP MX\TRW5ITVJ?
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KYSE-450 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ5Lkm4OlIh|ryP M2nyeHNCVkeHUh?=
S-117 NHPJOYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJ7LkO4OVch|ryP NGj4WZFUSU6JRWK=
SW13 NIHIe41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17XWGlEPTB;MkmuPFUyQSEQvF2= MYXTRW5ITVJ?
ES3 NEH6[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfLTWM2OD1|MD6zO|M{KM7:TR?= NHTQeZRUSU6JRWK=
HCT-116 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfJfXNZUUN3ME2zNE42PTV2IN88US=> M4TKO3NCVkeHUh?=
NCI-H1693 MnT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofjTWM2OD1|MD61PVQzKM7:TR?= NFX5VnVUSU6JRWK=
VM-CUB-1 MkHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonJTWM2OD1|MD62OFE{KM7:TR?= MVHTRW5ITVJ?
NCI-H2170 M3rmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jTU2lEPTB;M{GuOVc5PCEQvF2= MonhV2FPT0WU
ALL-PO MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nLUWlEPTB;M{GuPFQzQCEQvF2= M4\H[3NCVkeHUh?=
NCI-H661 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHXU2xKSzVyPUOyMlA3OjNizszN MYXTRW5ITVJ?
NCI-H2347 MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:1fZY5UUN3ME2zNk41QDN5IN88US=> M4DUenNCVkeHUh?=
FTC-133 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFeySGJKSzVyPUOyMlcxPiEQvF2= NVTqSXNpW0GQR1XS
COLO-829 NEnVcGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTLTWM2OD1|Mz6zOFY4KM7:TR?= M2HrOHNCVkeHUh?=
GOTO MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zvV2lEPTB;M{OuOVI2QCEQvF2= NG\VV|JUSU6JRWK=
YAPC NHPxTW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLkU|cyUUN3ME2zN{45OTV7IN88US=> MX7TRW5ITVJ?
LCLC-103H M4XBPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TaR2lEPTB;M{SuNVYzPCEQvF2= MXTTRW5ITVJ?
SiHa Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPyd5NKSzVyPUO0MlM5OTdizszN M13DXHNCVkeHUh?=
LK-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUi0ZmY4UUN3ME2zOE42PzB6IN88US=> MXjTRW5ITVJ?
KP-N-YS MoO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTN2LkeyNFIh|ryP MYfTRW5ITVJ?
NCI-SNU-1 NF\mWZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXrTFRKSzVyPUO1MlE4QSEQvF2= NUnKXHdIW0GQR1XS
KNS-81-FD NH\wSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOwO|VKSzVyPUO1MlY3OyEQvF2= NY\qb2d7W0GQR1XS
SCC-9 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfqUW1KSzVyPUO2MlcyPDZizszN M3vpTnNCVkeHUh?=
SH-4 NHq0[2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTUcmlsUUN3ME2zOk44OyEQvF2= Mny4V2FPT0WU
HCC-1954 NG\mUYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PDVmlEPTB;M{euNlczQSEQvF2= NXfKXJBWW0GQR1XS
BALL-1 M1:5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLGTWM2OD1|Nz61N|E3KM7:TR?= MYTTRW5ITVJ?
BE-13 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X5[GlEPTB;M{euO|AyQCEQvF2= MWTTRW5ITVJ?
COLO-678 NX\XcVJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TPd2lEPTB;M{euPVQ{PyEQvF2= MYnTRW5ITVJ?
SK-MEL-3 NIHac3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DwdGlEPTB;M{iuNlM6PyEQvF2= MUjTRW5ITVJ?
OAW-28 M2\tTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf2TWM2OD1|OD62N|kh|ryP M1PsUnNCVkeHUh?=
CAMA-1 NEfBdYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTN6Lkm2PVEh|ryP NVS4bYxiW0GQR1XS
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A3-KAW M2\0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfpTZVKSzVyPUSwMlM3PjFizszN NYPl[HRDW0GQR1XS
SK-MEL-24 NGjT[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfUV25KSzVyPUSwMlU6OzFizszN NITGSWNUSU6JRWK=
KYSE-140 MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTRyLkexOlUh|ryP MYfTRW5ITVJ?
MOLT-16 MoK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfZPJVKSzVyPUSxMlE2OzZizszN NGDSSoZUSU6JRWK=
CFPAC-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTR{LkWyNVEh|ryP NUDscndoW0GQR1XS
NB14 NUDOUXhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn3[pRKSzVyPUSyMlcxOjdizszN NGH5XIRUSU6JRWK=
COLO-792 NGPTVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3qwTmlEPTB;NEKuPFk3OSEQvF2= MljjV2FPT0WU
RH-1 NEnTOW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTR|LkS4N|Yh|ryP NHTIVIdUSU6JRWK=
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Ca-Ski MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTuTWM2OD12ND64NVE1KM7:TR?= MYnTRW5ITVJ?
KGN NHXaVoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{KzVGlEPTB;NEiuN|A3OyEQvF2= M{ntNXNCVkeHUh?=
UACC-62 NFfwOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTR6LkSwO|Ih|ryP MWTTRW5ITVJ?
NCI-H358 Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnOUXhKSzVyPUS5MlMxOThizszN MVTTRW5ITVJ?
LS-411N M3jsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjwVVNKSzVyPUS5MlMyOThizszN NFzsZWZUSU6JRWK=
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... Click to View More Cell Line Experimental Data

In vivo試験 Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]
臨床試験 A Phase I study of GDC-0941 in patients with locally advanced or metastatic solid tumors, Non-Hodgkin's lymphoma, or multiple myeloma (MM) (expansion stage only) for which standard therapy either does not exist or has proven ineffective or intolerable is
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Scintillation proximity assay Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.

細胞アッセイ: [2]

細胞株 SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 48 and 72 hours
実験の流れ Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.

動物実験: [2]

動物モデル NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
製剤 Dissolved in 10% DMSO, 5% Tween 20, 85% water
投薬量 ~150 mg/kg/day
投与方法 Oral gavage

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Pictilisib (GDC-0941) SDF
分子量 513.64
化学式

C23H27N7O3S2

CAS No. 957054-30-7
保管 2年-20℃
6月-80℃in solvent
別名 RG7321
溶解度 (25°C) * In vitro DMSO 44 mg/mL (85.66 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine

文献中の引用 (57)

技術サポート&よくある質問(FAQ)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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