Pictilisib (GDC-0941) 化学構造
分子量: 513.64

高品質保証

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Quality Control & MSDS

製品説明

  • Compare PI3K Inhibitors
    PI3K製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法
  • Pictilisib (GDC-0941)のメカニズム

製品の説明

生物活性

製品説明 Pictilisib (GDC-0941)は、PI3Kα、PI3Kβ、PI3KδとPI3Kγの強力な阻害剤で、IC50 がそれぞれ 3 nM、 33 nM、 3 nM、75 nMです。
ターゲット PI3Kα PI3Kβ PI3Kδ PI3Kγ
IC50 3 nM 33 nM 3 nM 75 nM [1]
In vitro試験 GDC-0941 is equipotent against PI3Kα and PI3Kδ as well as PI3Kα mutants E545-K and H1047-R, displaying modest levels of selectivity against PI3Kβ (10-fold) and PI3Kγ (25-fold), and greater levels of selectivity against members of PI3K class II, III, and IV, including C2β, Vps34, DNA-PK, and mTOR. GDC-0941 potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA-MB-361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. GDC-0941 inhibits the proliferation of U87MG, A2780, PC3, and MDA-MB-361 cells with IC50 of 0.95 μM, 0.14 μM, 0.28 μM, and 0.72 μM, respectively. [1] GDC-0941 treatment potently inhibits the proliferation of both trastuzumab-sensitive and -insensitive HER2-amplified cells with IC50 of 149-944 nM. GDC-0941 inhibits proliferation of HER2-amplified cells that harbor PIK3CA mutations with IC50 of <500 nM, and effectively inhibits both proliferation and viability of HER2-amplified breast cancer cells that are resistant to trastuzumab due to PTEN loss. [2] GDC-0941 significantly inhibits the growth of HCT116, DLD1 and HT29 cells with GI50 of 1081 nM, 1070 nM and 157 nM, respectively. [3] GDC-0941 inhibits tumor cell proliferation, induces apoptosis and suppresses centroblast population. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
Sf9 MYfLbY5ie2ViQYPzZZk> MXOxJIg> MnHGSG1UVw>? M3jvV2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyZHXseIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIEhf2m2aDDJR|UxKG:oIECuNFA{KM7:TR?= MYGxPFc2PDZ3NB?=
Sf9 NF;uOHBMcW6jc3WgRZN{[Xl? NVjLZolzOSCq M3vvWmROW09? MorlTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGgyODR5LWKgcZV1[W62IHX4dJJme3OnZDDpckBU\jliY3XscJMh[2:neIDy[ZN{cW6pIIC4OYFteGijIIfpeIghUUN3MDDv[kAxNjByMzFOwG0> NGDhWZYyQDd3NE[1OC=>
Sf9 NFy1NnJMcW6jc3WgRZN{[Xl? MY[xJIg> NHmxRXFFVVOR NXPxNoJMUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKEV3NEWtT{BufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? NHPz[G0yQDd3NE[1OC=>
Sf9 M1\6fWtqdmG|ZTDBd5NigQ>? MXqxJIg> NUHQRpJzTE2VTx?= MoPmTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCzN{DPxE1? M1;tcFE5PzV2NkW0
Sf9 MlvUT4lv[XOnIFHzd4F6 NEH4RmMyKGh? MojsSG1UVw>? NYHVSFBbUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDhcJBp[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[Q>? NUTZRZBYOTh5NUS2OVQ>
MDA-MB-361 MUnGeY5kfGmxbjDBd5NigQ>? MVSyJIg> NGXPVFVFVVOR NVuzZ5U{UW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkig{txO MkO2NVg4PTR4NUS=
PC3 MWTGeY5kfGmxbjDBd5NigQ>? NIj3WXAzKGh? NITHR3pFVVOR NI[5fY5KdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDQR|Mh[2WubIOge4l1cCCLQ{WwJI9nKDBwMEO3JO69VQ>? M1LGd|E5PzV2NkW0
U87MG NH7Le4tHfW6ldHnvckBCe3OjeR?= Mn3DNkBp MUXEUXNQ MXjJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCXOEfNS{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yNE[g{txO NUDC[3c5OTh5NUS2OVQ>
MDA-MB-361 NW\mPFUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvJW2c6PiCq NWjlT28zTE2VTx?= NGLPXlRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1|NkGgZ4VtdHNid3n0bEBRUUt|Q1GgSVU1PS2NIH31eIF1cW:wIIfpeIghUUN3MDDv[kAxNjd{IN88US=> NWK3UHI3OTh5NUS2OVQ>
A2780 NFfzVG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO5OkBp MVfEUXNQ NXrYepBxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{B4cXSqIGDJT|NESSCjbnSgVHRGViCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4yPCEQvF2= NULWO4xxOTh5NUS2OVQ>
PC3 NE\u[VhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT3Z4E6PiCq MoLISG1UVw>? NEnMOJZKSzVyPUCuNlgh|ryP NEnHO3AyQDd3NE[1OC=>
U87MG NIHQV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXe5OkBp NX3z[pBuTE2VTx?= MV\JR|UxRTBwOUWg{txO M3Ta[VE5PzV2NkW0
Sf9 MlH6T4lv[XOnIFHzd4F6 NFziPHA{OCCvaX6= Mn3ESG1UVw>? M1jGXmlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDhcY92dnRib3[gRXRRKGOxboP1cYVlKHerdHigTWM2OCCxZjCwMlA1OiEQvF2= NXXrb2tCOjJ3NEizOFI>
RAW 264.7 NXP4XWptU2mwYYPlJGF{e2G7 M{Hu[VkxKG2rbh?= Mo\USG1UVw>? NVzlRoV3UW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5{OUig{txO M4fPXlIzPTR6M{Sy
Sf9 NFK5TGtMcW6jc3WgRZN{[Xl? Mn7DNUBp MVnJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPLZoV1[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhW0Z7IHPlcIx{KHerdHigTWM2OCCxZjCwMlAyPyEQvF2= NGmyV4YzOzV2ME[0OS=>
Sf9 NFHMem9McW6jc3WgRZN{[Xl? NXjOXYxMOSCq MnHoTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4RmdHSjIHX4dJJme3OnZB?= NEXuc3QzOzV2ME[0OS=>
Sf9 NV\CZpJ[U2mwYYPlJGF{e2G7 NYXsZWNPOSCq M3jFVGlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2to[W2vYTDlfJBz\XO|ZXS= MoPqNlM2PDB4NEW=
Sf9 NGPyNnJMcW6jc3WgRZN{[Xl? NGLWV2QyKGh? M1XQOmlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tidHCqYTDlfJBz\XO|ZXS= MlTiNlM2PDB4NEW=
SKOV3 M{TZc2tqdmG|ZTDBd5NigQ>? MYexJO69VQ>? NVPZNotJOSCq MVHEUXNQ MYTJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9v MoTxNlM{PjB|NEi=
MCF7 M1zpcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYexJO69VQ>? NH\0NmM6PiCq MVXEUXNQ MYrHTVUxRTBwMEewNkDPxE1? Mn\PNlM{PjB|NEi=
SKOV3 Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjWbYUyKM7:TR?= M3LJRVk3KGh? MnLmSG1UVw>? MUjHTVUxRTBwMUS3OkDPxE1? MmTnNlM{PjB|NEi=
PC3 NFXIW4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonhO|IhcA>? MYXEUXNQ MULJR|UxRTBwMkig{txO NIj0dGozOTl6MUexOC=>
MCF7.1 NXvKR5FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjnTXE4OiCq MnHnSG1UVw>? M{PvOWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochUEWUMjDn[Y5mKHerdHigTWM2OCCxZjCwMlI5KM7:TR?= NVnrcJV{OjF7OEG3NVQ>
MCF7-neo/Her2 NGfzU|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojWO|IhcA>? NILUO3lFVVOR M{K4bGlEPTB;MD6yPUDPxE1? NVHlPIoyOjN4NkK5NFM>
MCF7-neo/Her2 M3TQNmtqdmG|ZTDBd5NigQ>? MVvJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YhSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDTOFc{KHerdHigTWM2OCCxZjCwMlAxPyEQvF2= NYD0WIxwOjN4NkK5NFM>
PC3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPIcFhsPzJiaB?= NGHGcZFFVVOR NYX4Uo5uTUN3ME2wMlM1KM7:TR?= NES4VFgzOTl6NU[zPS=>
MCF7.1 M3PkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjvO|IhcA>? NE\obnhFVVOR NUX6XHJSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCSSUPLZYxxcGFibYX0ZY51KHerdHigSWM2OCCxZjCwMlM6KM7:TR?= Mn;ZNlE6QDV4M{m=
PC3 NWHRWmpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYe3NkBp MXXEUXNQ NX;1dmdZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOg[IVncWOrZX70JIlvKFCWRV6ge4l1cCCLQ{WwJI9nKDBwM{mg{txO NF;kSnMzODB3ME[2PS=>
MCF7.1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX[3NkBp NHrrOY9FVVOR MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCLQ{WwJI9nKDBwM{Sg{txO MkW1NlAxPTB4Nkm=
MCF7.1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XZWFczKGh? MkTRSWM2OD1yLkeyJO69VQ>? MlyzNlA{PDZ4NU[=
NCI-H1975 MlrKR5l1d3SxeHnjJGF{e2G7 NIX6eVI4OiCq NWT6VmNRUUN3ME2wMlI4KM7:TR?= MlHKNlMxPTl3NEW=
H460 M33acGN6fG:2b4jpZ{BCe3OjeR?= NUS2bHU1PzJiaB?= Mm\vTWM2OD1yLki3JO69VQ>? M1XlRVI{ODV7NUS1
HT-29 MVnDfZRwfG:6aXOgRZN{[Xl? M4\TbFczKGh? M1r1SGlEPTB;MD62OkDPxE1? NUXr[4ZNOjNyNUm1OFU>
HepG2 NGi0b3VEgXSxdH;4bYMhSXO|YYm= NYr1fXZ7PzJiaB?= NUHWeHZzUUN3ME2xJO69VQ>? MmL1NlMxPTl3NEW=
SGC7901 NVTMZo1DS3m2b4TvfIlkKEG|c3H5 NX;Nb|U{PzJiaB?= NIDjWotKSzVyPUGuPEDPxE1? MUOyN|A2QTV2NR?=
NCI-H226 MofJR5l1d3SxeHnjJGF{e2G7 NFO1XJU4OiCq NIDjcYhKSzVyPUKuPUDPxE1? M1;GS|I{ODV7NUS1
A549 MkT6R5l1d3SxeHnjJGF{e2G7 M4j1V|czKGh? NFLT[lRKSzVyPU[uPUDPxE1? M4PVWFI{ODV7NUS1
U87MG NIjDN3pEgXSxdH;4bYMhSXO|YYm= MnrZO|IhcA>? NEHGepVKSzVyPUeuO|ch|ryP NFvybWszOzB3OUW0OS=>
HBC4 M4jWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnsc4dIUTVyPT22MlA{KE1? MljVNlI{OzZ{NE[=
BSY1 NFHaVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7sc4dIUTVyPT22MlkxKE1? NVTLW292OjJ|M{[yOFY>
HBC5 M1zKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nOe4xw\0eLNUC9MVYvPjBiTR?= NVHVPZRPOjJ|M{[yOFY>
MCF7 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED0OVJtd2eJSUWwQU04NjN|IF2= MYCyNlM{PjJ2Nh?=
MDA-MB-231 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXTcI9oT0l3ME2tOU41PiCP MkTtNlI{OzZ{NE[=
U251 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXlN4RwdG:pR1m1NF0uPS53MDDN NFvVcXAzOjN|NkK0Oi=>
SF268 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCzRXZOdG:pR1m1NF0uPS5|OTDN M4ntflIzOzN4MkS2
SF295 M4LH[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PmXIxw\0eLNUC9MVYvOzdiTR?= M1vrdlIzOzN4MkS2
SF539 NXn6fYdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmWxcI9oT0l3ME2tOk42OCCP NX;UZmRlOjJ|M{[yOFY>
SNB75 NELDWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrjN5Btd2eJSUWwQU04NjFyIF2= M1v5[VIzOzN4MkS2
SNB78 NEPvU|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3sc4dIUTVyPT22MlUzKE1? NXvHOZV4OjJ|M{[yOFY>
HCC2998 NXXKSJZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjsc4dIUTVyPT22MlI6KE1? NU\YTpdPOjJ|M{[yOFY>
KM12 NGfjVlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfaZXNtd2eJSUWwQU02Njd4IF2= MXOyNlM{PjJ2Nh?=
HT-29 M1jRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojWcI9oT0l3ME2tOk4{OCCP NXm0SWV3OjJ|M{[yOFY>
HCT15 NH3zbWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S4NIxw\0eLNUC9MVYvOTJiTR?= M1XmO|IzOzN4MkS2
HCT116 NYDDO4NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\kblB1dG:pR1m1NF0uPS56NzDN NIX1Z|EzOjN|NkK0Oi=>
NCI-H23 NX;veJVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq4[2tpdG:pR1m1NF0uPS55MzDN MmjLNlI{OzZ{NE[=
NCI-H226 M2CwcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;5dYl{dG:pR1m1NF0uPi5{MTDN MUWyNlM{PjJ2Nh?=
NCI-H522 M1O5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXoU5RTdG:pR1m1NF0uPi53ODDN M4q2XFIzOzN4MkS2
NCI-H483 NY\DTGdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzuVXVbdG:pR1m1NF0uPi53NjDN MUCyNlM{PjJ2Nh?=
A549 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmxV|NjdG:pR1m1NF0uPi5zNTDN NX7abnhrOjJ|M{[yOFY>
DMS273 NEmxdoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m2[Ixw\0eLNUC9MVYvPDNiTR?= NGjHPYEzOjN|NkK0Oi=>
DMS114 M2DBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorncI9oT0l3ME2tOU46OiCP NX\K[GhiOjJ|M{[yOFY>
LOXIMVI NUPqU4pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXEXmp6dG:pR1m1NF0uPi5{OTDN NGLqV44zOjN|NkK0Oi=>
OVCAR3 NXjsPGR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jEdYxw\0eLNUC9MVYvPzFiTR?= NYPuWJJGOjJ|M{[yOFY>
OVCAR4 NIG4UWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PMVoxw\0eLNUC9MVUvPzZiTR?= MoPaNlI{OzZ{NE[=
OVCAR5 MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHnUVVtd2eJSUWwQU03NjJ4IF2= NGjSZXYzOjN|NkK0Oi=>
OVCAR8 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPsc4dIUTVyPT21Mlc{KE1? NUnLO2cxOjJ|M{[yOFY>
SKOV3 Mlm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnYd2Vtd2eJSUWwQU03NjV{IF2= NVP6SVFpOjJ|M{[yOFY>
RXF631L MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXC[FRtd2eJSUWwQU03Njh6IF2= M4XDXFIzOzN4MkS2
ACHN M1v4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorLcI9oT0l3ME2tOk4xPyCP MlTnNlI{OzZ{NE[=
St-4 NXrzeYNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TWRYxw\0eLNUC9MVUvPTZiTR?= MoHkNlI{OzZ{NE[=
MKN1 M3\NRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfudXFFdG:pR1m1NF0uPy5yODDN NHXjbXczOjN|NkK0Oi=>
MKN7 MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PURYxw\0eLNUC9MVYvPTBiTR?= NHTqOXozOjN|NkK0Oi=>
MKN28 MnTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXGVIltd2eJSUWwQU02NjV{IF2= MY[yNlM{PjJ2Nh?=
MKN45 MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7mcI9oT0l3ME2tOk42PSCP NFPkcHQzOjN|NkK0Oi=>
MKN74 M3WyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvGPHg5dG:pR1m1NF0uPi5yMjDN NU\1OWF2OjJ|M{[yOFY>
DU145 M{fQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfp[pNvdG:pR1m1NF0uPS56NTDN MWqyNlM{PjJ2Nh?=
PC3 MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\sc4dIUTVyPT22MlY3KE1? NULlbXdHOjJ|M{[yOFY>
ES5 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjPTWM2OD13MD6yNUBvVQ>? NUjyOmh[W0GQR1XS
HH MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7We3BKUUN3ME2xNVEvODhibl2= NVXLdYJOW0GQR1XS
MHH-PREB-1 MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGGzdmdKSzVyPUGxOE4{KG6P M{P3U3NCVkeHUh?=
NCI-H1770 NV3kWVVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXhTWM2OD1zMkOuPFYhdk1? MX\TRW5ITVJ?
HuO9 Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJyNj6wNkBvVQ>? M1rlSnNCVkeHUh?=
HAL-01 MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrXbnJtUUN3ME2yNFYvPzNibl2= NX\CUlFyW0GQR1XS
NOS-1 M4HhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPFb2E2UUN3ME2yNVEvQDJibl2= M3fPWnNCVkeHUh?=
HGC-27 NILuTo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHqWIFKSzVyPUKxNk42PyCwTR?= NXnqT3VQW0GQR1XS
NB69 NGnnNYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLlXoVCUUN3ME2yOFUvOjdibl2= MVfTRW5ITVJ?
RS4-11 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJ4MT63OkBvVQ>? M2D5TnNCVkeHUh?=
DOK M1jXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLt[WNKSzVyPUOwNU44KG6P MX\TRW5ITVJ?
LB2241-RCC Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXsTWM2OD1|MEOuPFQhdk1? NV7XbopRW0GQR1XS
NCI-H1623 NHHwOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DMVGlEPTB;M{C0MlA5KG6P MUHTRW5ITVJ?
YH-13 NVTDSpM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTzOGtKSzVyPUOwOE4{OiCwTR?= MXjTRW5ITVJ?
BPH-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTNzNDDuUS=> MXXTRW5ITVJ?
AN3-CA NF7mXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTN2MD6zO{BvVQ>? M1nKU3NCVkeHUh?=
ES7 NUSwPWRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLBRpN6UUN3ME2zOFEvQTlibl2= MmrsV2FPT0WU
MDA-MB-175-VII M1XTZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT0[JNMUUN3ME2zOVIvQTJibl2= M3\oOnNCVkeHUh?=
GAMG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXVdm56UUN3ME2zO|AvQDVibl2= M4L2R3NCVkeHUh?=
CHL-1 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vVd2lEPTB;M{e4MlY2KG6P Mn\nV2FPT0WU
NB7 M175Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DPVWlEPTB;M{i5Mlg{KG6P M2DVW3NCVkeHUh?=
MFE-280 NUPoV21pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjpTWM2OD12MUiuNkBvVQ>? M2jXfnNCVkeHUh?=
HL-60 NVHxTZNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTR{NT63OUBvVQ>? NHvse|FUSU6JRWK=
GCIY NUfGTFJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR|Mz64JI5O MWfTRW5ITVJ?
MDA-MB-361 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\IUGlEPTB;NEO5MlE{KG6P MWHTRW5ITVJ?
LXF-289 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEL2WHRKSzVyPUS0PE4zPyCwTR?= NET6bGpUSU6JRWK=
NBsusSR NVXqfnRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTR6OD64OUBvVQ>? NV\wUnRyW0GQR1XS
KU-19-19 NH;6XVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn0SodZUUN3ME21NVYvODdibl2= Mm\uV2FPT0WU
A204 MoCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTV{Mj6zN{BvVQ>? MXTTRW5ITVJ?
LB1047-RCC M{OwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULDNmVbUUN3ME21NlIvQTNibl2= M4r2W3NCVkeHUh?=
COLO-684 NXXCWGF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLSTFNKSzVyPUWyN{4yOSCwTR?= MW\TRW5ITVJ?
PA-1 MlfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTV|Mj60NUBvVQ>? NFnCb49USU6JRWK=
MG-63 MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3flPWlEPTB;NUSxMlEyKG6P MmHkV2FPT0WU
BHT-101 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HBSWlEPTB;NUS0Mlk1KG6P MWrTRW5ITVJ?
NKM-1 NU\MZWJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X2UmlEPTB;NUmzMlA6KG6P MWnTRW5ITVJ?
T47D M1yzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTTUYhJUUN3ME21PVcvPTZibl2= NUHYd5o{W0GQR1XS
MOLT-4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTZ{Mz62NkBvVQ>? NXfQdnZsW0GQR1XS
IGROV-1 M{LlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTZ|ND6zNUBvVQ>? MYXTRW5ITVJ?
ES4 NV[yVmt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K0dGlEPTB;NkO5MlU1KG6P M1HROXNCVkeHUh?=
HuO-3N1 MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvNTWM2OD14NEKuN|ghdk1? NYDKXppDW0GQR1XS
NEC8 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P3UWlEPTB;NkWzMlU4KG6P MnjsV2FPT0WU
HO-1-N-1 M3O0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVraUW9XUUN3ME22OVkvOTdibl2= NEfK[VZUSU6JRWK=
EPCL-272H M3nrPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTZ6Nz6yNUBvVQ>? NF\Nd5VUSU6JRWK=
D-263MG M12xSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnubVFDUUN3ME23NVgvOSCwTR?= M{Tl[3NCVkeHUh?=
MV-4-11 MojhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITjN4FKSzVyPUeyOE4{OSCwTR?= MmDGV2FPT0WU
SK-NEP-1 M3j3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\Db|U2UUN3ME23NlUvQTRibl2= MY\TRW5ITVJ?
SW872 MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFriRYZKSzVyPUeyO{45QSCwTR?= MVnTRW5ITVJ?
P30-OHK NGPoNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTd|MD63NUBvVQ>? MULTRW5ITVJ?
OMC-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTd3MT6wPUBvVQ>? MknGV2FPT0WU
LoVo M1nXRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTd5Nz65JI5O NEDaTZpUSU6JRWK=
LNCaP-Clone-FGC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTd7Nj6zOEBvVQ>? MXrTRW5ITVJ?
L-363 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C2WGlEPTB;N{m4MlQzKG6P M3Li[XNCVkeHUh?=
ES8 M3HzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfWTWM2OD16MUCuOVIhdk1? MX;TRW5ITVJ?
697 NX;DfWkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHCTWM2OD16M{GuOVUhdk1? M{DtOHNCVkeHUh?=
HSC-3 NFnxW4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[x[HZUUUN3ME24N|kvPTRibl2= NYLsfGp1W0GQR1XS
H4 M{DVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPEVYNKSzVyPUi1NE45PSCwTR?= MVnTRW5ITVJ?
QIMR-WIL MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEOx[3dKSzVyPUi2OU4zKG6P NH6wUoxUSU6JRWK=
OAW-42 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPSZW14UUN3ME24O|IvOTlibl2= NFi3UIRUSU6JRWK=
MCF7 NHPJXFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu3XJBKSzVyPUi5PE42QSCwTR?= NHzscFdUSU6JRWK=
SCC-25 NGPFUJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD0TY14UUN3ME25NVQvOTlibl2= NWTtUJB3W0GQR1XS
NCI-H1563 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTlzNT65PUBvVQ>? NFHUR3dUSU6JRWK=
OVCAR-5 M3u5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\pc21YUUN3ME25OFAvOTdibl2= M3\XWXNCVkeHUh?=
HDLM-2 NYPhPIoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTLTWM2OD17NEmuNkBvVQ>? NF[3W5ZUSU6JRWK=
NB5 NFLncIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXab5pKSzVyPUm1Ok43KG6P MlfzV2FPT0WU
NCI-H292 NEPNV4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTl5ND6zNkBvVQ>? M3v3ZnNCVkeHUh?=
A101D NUnC[W1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLTeIE1UUN3ME25PVAvOTlibl2= NX7Ed|FJW0GQR1XS
NCI-H1648 NVm3UYFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXtXm9KSzVyPUm5PE42OSCwTR?= M4i5UHNCVkeHUh?=
EKVX NFPPPWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVftNnM6UUN3ME2xMlAyOjlizszN NHG1TVFUSU6JRWK=
SW1710 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3rR2VKSzVyPUGuNFQzOzNizszN M2ft[nNCVkeHUh?=
WM-115 M2THfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L0dmlEPTB;MT6wOlY2PiEQvF2= MUfTRW5ITVJ?
CAL-54 NESzemdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfaOXJKSzVyPUGuNFcxQDFizszN NW\NTY9XW0GQR1XS
TGBC24TKB NFnzemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LNNWlEPTB;MT6wPFA1PSEQvF2= MlfiV2FPT0WU
NCI-H520 NYG3boR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjPVmdKSzVyPUGuNFg6PjdizszN MV\TRW5ITVJ?
D-423MG MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFwMEm5OlIh|ryP Mn\sV2FPT0WU
BFTC-905 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTFwMUO0OFkh|ryP MUDTRW5ITVJ?
HT MlrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LqbmlEPTB;MT6xN|Q4QCEQvF2= NUHsb|NbW0GQR1XS
CTB-1 NXv0dpVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\WNWlEPTB;MT6xOFI6OyEQvF2= M3r5WnNCVkeHUh?=
Hs-578-T NVjIS4R7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTFwMUm1OlUh|ryP NVTEPI1TW0GQR1XS
HuH-7 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHhTWM2OD1zLkKwPVQ6KM7:TR?= MoLKV2FPT0WU
LB996-RCC M4K3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rYN2lEPTB;MT6yNlE4PyEQvF2= NHzLRWJUSU6JRWK=
KYSE-270 M3ryUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjHZ3VKSzVyPUGuNlk4OzRizszN NX6x[4lqW0GQR1XS
A4-Fuk M1z5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwMkm5PVMh|ryP NUKyfphtW0GQR1XS
A498 M4qzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPZNFF3UUN3ME2xMlMxPDd2IN88US=> NUTwZoc3W0GQR1XS
SK-MEL-1 Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFwM{C2O|kh|ryP NFO0O2xUSU6JRWK=
AU565 M4H0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTFwM{G4OlMh|ryP NIOyUXNUSU6JRWK=
Saos-2 MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnSxTWM2OD1zLkOzNlA2KM7:TR?= NGi2XGJUSU6JRWK=
A549 Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfkZnBKSzVyPUGuN|k6PyEQvF2= NEi3UHVUSU6JRWK=
BFTC-909 MlWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T2WWlEPTB;MT60N|MxPSEQvF2= NELaU|hUSU6JRWK=
MDA-MB-415 NWryXFZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fVemlEPTB;MT60PFY6OiEQvF2= M{[1N3NCVkeHUh?=
639-V M4\jRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHWTWM2OD1zLkWwNlQ2KM7:TR?= MV3TRW5ITVJ?
A704 NX;sVZdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XlcGlEPTB;MT61NFc5PSEQvF2= M2[yOnNCVkeHUh?=
PANC-03-27 M3rXemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPsRmZKSzVyPUGuOVE1ODhizszN NHTnb5dUSU6JRWK=
SK-MEL-28 M33uUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHVfHBKSzVyPUGuOVYxQDVizszN NWCzOFZoW0GQR1XS
Ramos-2G6-4C10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHiyRYpKSzVyPUGuOlA4PDZizszN M2DEWHNCVkeHUh?=
HuP-T4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7HTWM2OD1zLk[wO|c5KM7:TR?= NI\PS2JUSU6JRWK=
VA-ES-BJ NUn3N2U6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCzUoxwUUN3ME2xMlYyOjdizszN NUPtPYU3W0GQR1XS
EFM-19 Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PmR2lEPTB;MT62NVgyKM7:TR?= MYHTRW5ITVJ?
G-401 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTRXZZKSzVyPUGuOlIyPjRizszN MWjTRW5ITVJ?
D-566MG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXmTWM2OD1zLk[yOVMh|ryP NHPSbIxUSU6JRWK=
JVM-3 NVrKNWxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnmWlFKSzVyPUGuOlQ5PzVizszN MULTRW5ITVJ?
TK10 NWXHc3BRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnlOJdKSzVyPUGuOlcxQDNizszN M1fMcHNCVkeHUh?=
BT-20 NID0UohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXlSZp6UUN3ME2xMlY5QTB{IN88US=> NXzZW5RPW0GQR1XS
EGI-1 NIDtV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvwepdKSzVyPUGuPFQ4ODFizszN MWnTRW5ITVJ?
EW-16 M{C4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnWPFVpUUN3ME2xMlg2OTh{IN88US=> NYjUbIlSW0GQR1XS
NCI-H2228 NWXBb2dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjDfFk2UUN3ME2xMlg2OjB|IN88US=> Mkn4V2FPT0WU
BB49-HNC NH\XboRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTFwOEi2PVIh|ryP MVrTRW5ITVJ?
G-402 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzZTWM2OD1zLki5O|k4KM7:TR?= NEfh[nNUSU6JRWK=
NCI-H526 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXPTWM2OD1zLkmxN|kh|ryP MWPTRW5ITVJ?
ME-180 NXPufWRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXBTHNNUUN3ME2xMlk{PDd5IN88US=> M2TERnNCVkeHUh?=
PFSK-1 M33UcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TsPGlEPTB;MT65OFQ2QCEQvF2= NFHzToVUSU6JRWK=
TYK-nu MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWSzPFRUUUN3ME2xMlk2QDJ|IN88US=> NWixRY9vW0GQR1XS
HOS NXrLU|VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTFwOUe5OFgh|ryP MmfDV2FPT0WU
T98G MlvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTFwOUmwNFYh|ryP M13QcXNCVkeHUh?=
SK-MES-1 Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwMEGzN|Ih|ryP M1mwXHNCVkeHUh?=
SNB75 NGLPVmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT0TWM2OD1{LkCxOVQyKM7:TR?= NFe2WmxUSU6JRWK=
LAMA-84 NVy5SpVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTlTWM2OD1{LkCyOlg6KM7:TR?= NGfUd45USU6JRWK=
CAL-39 NG\SdJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJwMEOyPEDPxE1? MWfTRW5ITVJ?
LOXIMVI MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJwMESwPFQh|ryP NX61RXJQW0GQR1XS
NH-12 MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33jUWlEPTB;Mj6wOVQzPCEQvF2= MV\TRW5ITVJ?
NCI-H1048 NUDJUphwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrOTWM2OD1{LkGwOVIh|ryP MoHYV2FPT0WU
KS-1 M4nGVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJwMUGwNFEh|ryP NVXkOXRwW0GQR1XS
NCI-N87 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjFc5pTUUN3ME2yMlE{Ozh2IN88US=> NUnFWpdwW0GQR1XS
CHP-212 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rzVWlEPTB;Mj6xPFQ1OiEQvF2= MUHTRW5ITVJ?
HCC1419 M13QRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoD3TWM2OD1{LkKxNVE2KM7:TR?= MVTTRW5ITVJ?
ES1 NFHJW2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrmSlhKSzVyPUKuNlE{OjZizszN NICyVo9USU6JRWK=
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NCI-H1792 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrFTWM2OD15LkWxO|EyKM7:TR?= NHvyXHNUSU6JRWK=
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EW-13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHqOVRiUUN3ME23Mlg6QTd5IN88US=> MYfTRW5ITVJ?
no-11 MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTHTWM2OD15LkmwNVc1KM7:TR?= MVzTRW5ITVJ?
Daoy MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnBbXJKSzVyPUeuPVQ{OjFizszN MlnkV2FPT0WU
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SJRH30 M2frcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXWWXZzUUN3ME24MlE2QDd6IN88US=> NGq5[HpUSU6JRWK=
NCI-H2291 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HITGlEPTB;OD6yPVE5PyEQvF2= Mof5V2FPT0WU
J82 NFXnV29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRThwMkm0PVEh|ryP MV7TRW5ITVJ?
NCI-H596 MlfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPnTWM2OD16LkOxOFU{KM7:TR?= NWDSU2I3W0GQR1XS
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RH-18 NIraRXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jXZWlEPTB;OD6zOVA1PiEQvF2= NVXGU21HW0GQR1XS
SW48 M1Lub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\lPVBOUUN3ME24MlU6PDV|IN88US=> M{\LTnNCVkeHUh?=
RD M4LSd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PwUGlEPTB;OD61PVM6OSEQvF2= NG\iUpJUSU6JRWK=
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ES6 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHzSZpbUUN3ME24Mlc{OTF7IN88US=> M{DycnNCVkeHUh?=
TE-12 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLCeWpbUUN3ME24Mlc4PTB3IN88US=> NEe4c25USU6JRWK=
DBTRG-05MG NHTCOIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zwNGlEPTB;OD65NVIyPyEQvF2= M2LKe3NCVkeHUh?=
KINGS-1 NV71S5NwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37sdmlEPTB;OD65Nlk{QCEQvF2= M1u2ZnNCVkeHUh?=
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MN-60 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO2TWM2OD17LkK0OVQzKM7:TR?= M{naUHNCVkeHUh?=
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NCI-H446 M2[4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLsTWM2OD17LkO2NUDPxE1? MXTTRW5ITVJ?
C-33-A NHzydZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MormTWM2OD17LkSzPVg5KM7:TR?= M2HYUHNCVkeHUh?=
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CGTH-W-1 NEHY[2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLPTWM2OD17LkS5N|g1KM7:TR?= M4DZUHNCVkeHUh?=
RCM-1 NV\oZ4pCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nQbGlEPTB;OT62N|gxOSEQvF2= NXm5eodOW0GQR1XS
SN12C MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DUTmlEPTB;OT62OVM{QCEQvF2= NVfo[GM{W0GQR1XS
KLE NEHkWldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1voVWlEPTB;OT63NFAxQSEQvF2= MUHTRW5ITVJ?
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D-247MG MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn5R|B[UUN3ME2xNE4xPTZ6IN88US=> MnG3V2FPT0WU
MPP-89 NWr5VlNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknpTWM2OD1zMD6wPVQ3KM7:TR?= NVO5eYQ2W0GQR1XS
RVH-421 NHzsc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmqwTWM2OD1zMD6xOVA2KM7:TR?= M3OxeHNCVkeHUh?=
NCI-H460 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrSZm1mUUN3ME2xNE4zQDB4IN88US=> MYHTRW5ITVJ?
NOMO-1 M1\ZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXpSGhKSzVyPUGwMlM2OzJizszN M2\XbnNCVkeHUh?=
DEL NVu1eVhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrIVXhoUUN3ME2xNE4{Pzl2IN88US=> NFO0XJlUSU6JRWK=
HT55 MkjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPmTWM2OD1zMD62NlA2KM7:TR?= MUPTRW5ITVJ?
MC116 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFyLk[2OVUh|ryP MlS0V2FPT0WU
BB30-HNC MnT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFyLk[2PUDPxE1? NGnlOVNUSU6JRWK=
DJM-1 NFnYUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX20UmJSUUN3ME2xNE43QTR7IN88US=> NHr1S2tUSU6JRWK=
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MSTO-211H Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTFzLkC3NVYh|ryP NUPS[ZBlW0GQR1XS
SW837 Mm\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfnd|hWUUN3ME2xNU4xQTR7IN88US=> MoXZV2FPT0WU
HuCCT1 M3rud2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvwWIs3UUN3ME2xNU4yOjhzIN88US=> NYXhbFBNW0GQR1XS
RCC10RGB MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXTcoFSUUN3ME2xNU4yOzVizszN M4LSZ3NCVkeHUh?=
NMC-G1 M3vyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjsV2xKSzVyPUGxMlE1QTNizszN NV7m[4RbW0GQR1XS
NCI-H650 NGTV[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M174dmlEPTB;MUGuN|c6PCEQvF2= NFjLT2VUSU6JRWK=
HEC-1 M{i5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFzLkSzNlgh|ryP MmPJV2FPT0WU
DU-4475 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTFzLkezPVMh|ryP NX\BelhxW0GQR1XS
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HCC1569 NU\QZoRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLmTWM2OD1zMT63Olc5KM7:TR?= NVexZW9RW0GQR1XS
HCC1187 NF[xNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDZXVlKUUN3ME2xNU45PTh6IN88US=> NHzo[WpUSU6JRWK=
EW-11 NFTMXWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnTTWM2OD1zMT65OFc1KM7:TR?= NIT3OpdUSU6JRWK=
LB2518-MEL MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF{LkC1PUDPxE1? MVvTRW5ITVJ?
KALS-1 NFvFfVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLvNFBKSzVyPUGyMlg2PTNizszN MkXHV2FPT0WU
8505C NHLYZ5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkftTWM2OD1zMj64PFUh|ryP M1XiUHNCVkeHUh?=
SK-N-DZ NWGzOoNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33sbGlEPTB;MUOuNFQ2OyEQvF2= M{HjeXNCVkeHUh?=
CHP-134 NV\ESHJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzETWM2OD1zMz6xNVU5KM7:TR?= MkW2V2FPT0WU
HCE-T MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHke4NKSzVyPUGzMlI{PjRizszN NGThVZhUSU6JRWK=
LB-831-BLC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HGWGlEPTB;MUOuOlI1PiEQvF2= NWfLTHZRW0GQR1XS
OVCAR-4 NHi3eYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzpTWM2OD1zMz62OVI1KM7:TR?= Mn73V2FPT0WU
SW756 NF;FWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\kTWM2OD1zMz63NlQ3KM7:TR?= NGrUdJlUSU6JRWK=
OCUB-M MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLiTWM2OD1zMz64NVU3KM7:TR?= NHLlRlJUSU6JRWK=
SW982 M4[0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkThTWM2OD1zMz64Nlc3KM7:TR?= NH7RTo9USU6JRWK=
DB MnnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTF|LkizPFQh|ryP MXHTRW5ITVJ?
H-EMC-SS NXTmVFJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj5dIVlUUN3ME2xN{46OTN7IN88US=> NU\OU2ZKW0GQR1XS
VMRC-RCZ MnSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f1O2lEPTB;MUSuNFAyPSEQvF2= NW\Idpl7W0GQR1XS
CAKI-1 NGW2OIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF2LkCxN|Ih|ryP Mn\pV2FPT0WU
GI-1 NHPFVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XXcGlEPTB;MUSuNFY2QCEQvF2= M1HpNnNCVkeHUh?=
Ca9-22 NF3DOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC2T2xKSzVyPUG0MlYxPTRizszN NVrwUnFoW0GQR1XS
TE-5 NHzK[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[4TVBKSzVyPUG0MlczODhizszN NVnu[FUyW0GQR1XS
EFO-27 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTHTGtEUUN3ME2xOE44PjJ{IN88US=> M1PJTnNCVkeHUh?=
CAL-72 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDnNJk5UUN3ME2xOE44Pzh|IN88US=> MnvTV2FPT0WU
GP5d M{HvZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD5XmVVUUN3ME2xOU4xPDd2IN88US=> M4DFbHNCVkeHUh?=
CAS-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL2VmxKSzVyPUG1MlA3PiEQvF2= NH7rVIhUSU6JRWK=
A2058 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;2fGlEPTB;MUWuOVY{QCEQvF2= M33jenNCVkeHUh?=
PANC-08-13 NUPmbZZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofYTWM2OD1zNT62PFU6KM7:TR?= NH6ybG9USU6JRWK=
Detroit562 NG\mWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDpcnl[UUN3ME2xOU46OTN7IN88US=> M{nSXHNCVkeHUh?=
PANC-10-05 MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPKdotNUUN3ME2xOk4xQDJzIN88US=> M1vIbXNCVkeHUh?=
KOSC-2 NHnrdmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGq1NJNKSzVyPUG2MlEyOjVizszN MYLTRW5ITVJ?
GT3TKB MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrj[JI4UUN3ME2xOk4yQThzIN88US=> NUTLZ|IyW0GQR1XS
KM-H2 NGW0SXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYraOJVrUUN3ME2xOk4{PjR4IN88US=> MV7TRW5ITVJ?
LB771-HNC M33mcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF4LkS0NlIh|ryP M4WzPXNCVkeHUh?=
SF268 NH\MVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{CxWmlEPTB;MU[uOFUzKM7:TR?= M2LlN3NCVkeHUh?=
OE19 MmD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PMTmlEPTB;MU[uOVI1KM7:TR?= NV71[HZnW0GQR1XS
MLMA MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4C1T2lEPTB;MU[uOVU4OSEQvF2= NEfOdJVUSU6JRWK=
MDA-MB-231 NF34T5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;IfmlEPTB;MU[uO|E{PiEQvF2= NXrrWHlSW0GQR1XS
TGW Mn3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLRVldVUUN3ME2xOk45OTB{IN88US=> NUjQU5Z5W0GQR1XS
MDA-MB-453 MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF5LkCwNFMh|ryP M3z6TnNCVkeHUh?=
SNU-C2B MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\rTWM2OD1zNz6wNlM4KM7:TR?= Mk\xV2FPT0WU
A427 M4jLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF5LkKzN|Qh|ryP MWTTRW5ITVJ?
SK-MEL-2 NYnUN|dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XPVGlEPTB;MUeuN|IyOyEQvF2= MYHTRW5ITVJ?
KURAMOCHI NFXQXndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvGXWJiUUN3ME2xO{4{QDl5IN88US=> MYHTRW5ITVJ?
IST-MEL1 NIfDZ3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LIfWlEPTB;MUeuPVE5OiEQvF2= NX6xNpY6W0GQR1XS
NCI-H1793 NWjlemwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nVcGlEPTB;MUiuNVU5OSEQvF2= NVjndVJUW0GQR1XS
HCC1395 NEDOZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7iRnNNUUN3ME2xPE42PjFzIN88US=> MYXTRW5ITVJ?
NUGC-3 NEjXZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\CU2IyUUN3ME2xPE43PTh2IN88US=> MXHTRW5ITVJ?
BB65-RCC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH72ZoVKSzVyPUG4MlY3QSEQvF2= M37YXXNCVkeHUh?=
RMG-I MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHNTWM2OD1zOD63N|gzKM7:TR?= MV;TRW5ITVJ?
LS-513 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LiUmlEPTB;MUiuPVIzQCEQvF2= NGPke4hUSU6JRWK=
MFM-223 M4jHPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke1TWM2OD1zOT6wO|E3KM7:TR?= MXfTRW5ITVJ?
NCI-H727 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfpOlJCUUN3ME2xPU4{Ojl3IN88US=> MWHTRW5ITVJ?
KP-4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;aT2lEPTB;MUmuPFU{OSEQvF2= MXLTRW5ITVJ?
NB13 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLnTWM2OD1zOT64PFM6KM7:TR?= MoLxV2FPT0WU
UACC-893 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonQTWM2OD1zOT65O|U4KM7:TR?= NGrjb5JUSU6JRWK=
HT-1197 MoDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfUTm5KSzVyPUKwMlI6PThizszN MlS4V2FPT0WU
NCI-H2029 NFfBb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJyLkOyOlYh|ryP MW\TRW5ITVJ?
GI-ME-N NEDhOW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlK2TWM2OD1{MD6zN|c{KM7:TR?= NFvv[2VUSU6JRWK=
OVCAR-3 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJyLkW4NlIh|ryP NH3Fc3hUSU6JRWK=
HD-MY-Z NXiwZYpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPPbZFKSzVyPUKxMlM3QTZizszN M{fSOnNCVkeHUh?=
NTERA-S-cl-D1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJzLk[3NlIh|ryP NIXKdGpUSU6JRWK=
SCH MnnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq1TWM2OD1{Mj60PVYh|ryP NHLVWZdUSU6JRWK=
KARPAS-299 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTNcW1rUUN3ME2yN{4{QDh5IN88US=> NV7zSZRFW0GQR1XS
NCI-H1650 NF7KTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXrTWM2OD1{Mz65NlQyKM7:TR?= MXHTRW5ITVJ?
ACHN MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W5fmlEPTB;MkSuOFY2PiEQvF2= NVXJZ5hjW0GQR1XS
M059J MmPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:x[211UUN3ME2yOE42PjN2IN88US=> M4nBeHNCVkeHUh?=
AM-38 M4P2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2mySGlEPTB;MkWuOFgyKM7:TR?= M{nSPHNCVkeHUh?=
KG-1 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITK[llKSzVyPUK1MlU1QTRizszN NYXOSVZIW0GQR1XS
COLO-824 MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJ3LkW1PVkh|ryP M4H5bnNCVkeHUh?=
NCI-H1155 NHz4ZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXnXo9KSzVyPUK1MlU5PDdizszN MYDTRW5ITVJ?
NCI-H441 M33BTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33XOWlEPTB;MkWuO|Q3PSEQvF2= M4LyUHNCVkeHUh?=
J-RT3-T3-5 M{X2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH6TWM2OD1{Nj6zNFI4KM7:TR?= NGf3WHlUSU6JRWK=
JEG-3 MoToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJ4Lk[4NFUh|ryP MX3TRW5ITVJ?
RKO M1frPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nHZmlEPTB;Mk[uO|Y{OiEQvF2= M33UdXNCVkeHUh?=
CAL-85-1 MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHoZ2dNUUN3ME2yO{4zOTF6IN88US=> M2rrbHNCVkeHUh?=
CAL-120 MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{foeGlEPTB;MkeuOlkyPCEQvF2= M3vjWnNCVkeHUh?=
NCI-H2452 NEjRWVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\KNWlEPTB;MkeuO|cyPiEQvF2= NEnJbolUSU6JRWK=
NCI-H1395 NWDHSGRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nFfGlEPTB;MkeuO|g{OyEQvF2= NYD3e5RpW0GQR1XS
KYSE-450 MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T2NGlEPTB;MkeuPVg3OiEQvF2= MlLtV2FPT0WU
S-117 MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJ7LkO4OVch|ryP M1m4WHNCVkeHUh?=
SW13 NHLsfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJ7Lki1NVkh|ryP NUTqR3RvW0GQR1XS
ES3 NUm2fFNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXWVY9KSzVyPUOwMlM4OzNizszN MkDsV2FPT0WU
HCT-116 MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIf3fnJKSzVyPUOwMlU2PTRizszN MX7TRW5ITVJ?
NCI-H1693 NHfmN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL2TWM2OD1|MD61PVQzKM7:TR?= MWjTRW5ITVJ?
VM-CUB-1 M1L1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTrNVZkUUN3ME2zNE43PDF|IN88US=> NIrnSXRUSU6JRWK=
NCI-H2170 NYXQcYZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zHSmlEPTB;M{GuOVc5PCEQvF2= MVXTRW5ITVJ?
ALL-PO NFn4SGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTITWM2OD1|MT64OFI5KM7:TR?= MUfTRW5ITVJ?
NCI-H661 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;SW4ppUUN3ME2zNk4xPjJ|IN88US=> MWDTRW5ITVJ?
NCI-H2347 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTmc4xKSzVyPUOyMlQ5OzdizszN M1Sw[3NCVkeHUh?=
FTC-133 NXPJT4twT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LYbWlEPTB;M{KuO|A3KM7:TR?= NEHWU3dUSU6JRWK=
COLO-829 NUm4fGRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonkTWM2OD1|Mz6zOFY4KM7:TR?= NFrQb4NUSU6JRWK=
GOTO NF;DenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTN|LkWyOVgh|ryP MnG4V2FPT0WU
YAPC M1qzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3FUndKSzVyPUOzMlgyPTlizszN NGrqWYZUSU6JRWK=
LCLC-103H MljDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTN2LkG2NlQh|ryP NIS5SYtUSU6JRWK=
SiHa NX;YeHN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\LTWM2OD1|ND6zPFE4KM7:TR?= NUfx[Y9sW0GQR1XS
LK-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLPTWM2OD1|ND61O|A5KM7:TR?= M{PxV3NCVkeHUh?=
KP-N-YS M3PXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTN2LkeyNFIh|ryP NFS2dI5USU6JRWK=
NCI-SNU-1 NUTYfmJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTsTWM2OD1|NT6xO|kh|ryP MoXQV2FPT0WU
KNS-81-FD MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnkdHd3UUN3ME2zOU43PjNizszN NX7Pb4E{W0GQR1XS
SCC-9 MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[2TWM2OD1|Nj63NVQ3KM7:TR?= NWWxOoFZW0GQR1XS
SH-4 MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXoVZFCUUN3ME2zOk44OyEQvF2= NVnjdW13W0GQR1XS
HCC-1954 M2HoO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTN5LkK3Nlkh|ryP M{jyT3NCVkeHUh?=
BALL-1 NIX1TWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXniOWpUUUN3ME2zO{42OzF4IN88US=> MXHTRW5ITVJ?
BE-13 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjCTWM2OD1|Nz63NFE5KM7:TR?= M2DOXHNCVkeHUh?=
COLO-678 MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\zXHJKSzVyPUO3Mlk1OzdizszN M{fQXHNCVkeHUh?=
SK-MEL-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonrTWM2OD1|OD6yN|k4KM7:TR?= NEfqSmNUSU6JRWK=
OAW-28 M3;rUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33UZmlEPTB;M{iuOlM6KM7:TR?= NGT1NFhUSU6JRWK=
CAMA-1 NW[wXWg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkf5TWM2OD1|OD65OlkyKM7:TR?= MnvuV2FPT0WU
C2BBe1 M2fhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTN7LkixPEDPxE1? M1;FS3NCVkeHUh?=
A3-KAW MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTRyLkO2OlEh|ryP NVzP[ZpUW0GQR1XS
SK-MEL-24 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q0ZmlEPTB;NECuOVk{OSEQvF2= MV;TRW5ITVJ?
KYSE-140 M3\VcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NViwSZZMUUN3ME20NE44OTZ3IN88US=> MV\TRW5ITVJ?
MOLT-16 M{TSeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXGNXFKSzVyPUSxMlE2OzZizszN NVSzNXZFW0GQR1XS
CFPAC-1 MnXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7xTWM2OD12Mj61NlEyKM7:TR?= M3To[nNCVkeHUh?=
NB14 MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTR{LkewNlch|ryP Moj3V2FPT0WU
COLO-792 MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HRSWlEPTB;NEKuPFk3OSEQvF2= MlXjV2FPT0WU
RH-1 M3rlcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\QT2lEPTB;NEOuOFg{PiEQvF2= NGTCUHVUSU6JRWK=
NCI-H522 M1r0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTR2LkO1Olgh|ryP MoTWV2FPT0WU
Ca-Ski MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XDcGlEPTB;NESuPFEyPCEQvF2= Mmi3V2FPT0WU
KGN M2Tsemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2njVmlEPTB;NEiuN|A3OyEQvF2= MmjqV2FPT0WU
UACC-62 M1v5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnOTWM2OD12OD60NFczKM7:TR?= NUfSRYtmW0GQR1XS
NCI-H358 NF7PSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7UTWM2OD12OT6zNFE5KM7:TR?= NUjTTIJ{W0GQR1XS
LS-411N MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTR7LkOxNVgh|ryP NXXpbYFXW0GQR1XS
IST-MES1 MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULDPYg6UUN3ME20PU42PjJ3IN88US=> NFf2SVRUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 Administration of GDC-0941 at 75 mg/kg/day displays significant inhibitory effect against established human U87MG glioblastoma xenografts in female NCr athymic mice, with tumor growth inhibition of 83%. [1] Oral administration of GDC-0941 at 150 mg/kg/day inhibits the growth of HER2-amplified, trastuzumab-resistant MDA-MB-361.1 xenografts in mice, and significantly delays the tumor progression, in association with potent induced apoptosis in tumors. [2] GDC-0941 (75 mg/kg/day) treatment for 2 weeks induces ~40% reduction in tumor volume of spontaneous B-cell follicular lymphomas developed in PTEN+/-LKB1+/hypo mice, accompanied by ablation of phosphorylation of Akt, S6K and SGK (serum and glucocorticoid protein kinase) protein kinases. [4]
臨床試験 A Phase I study of GDC-0941 in patients with locally advanced or metastatic solid tumors, Non-Hodgkin's lymphoma, or multiple myeloma (MM) (expansion stage only) for which standard therapy either does not exist or has proven ineffective or intolerable is
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Scintillation proximity assay Recombinant human PI3Kα, PI3Kβ, and PI3Kδ are coexpressed in a Sf9 baculovirus system with the p85α regulatory subunit and purified as GST-fusion proteins using affinity chromatography on glutathione-sepharose. Recombinant human PI3Kγ is expressed as monomeric GST-fusions and purified similarly. GDC-0941 is dissolved in DMSO and added to 20 mM Tris-HCl (pH 7.5) containing 200 μg yttrium silicate (Ysi) polylysine SPA beads, 4 mM MgCl2, 1 mM dithiothreitol (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, and 4% (v/v) DMSO in a total volume of 50 μL. The recombinant GST-fusion of PI3Kα (5 ng), PI3Kβ (5 ng), PI3Kδ (5 ng), or PI3Kγ (5 ng) is added to the assay mixture to initiate the kinase reaction. After incubation for 1 hour at room temperature, the kinase reaction is terminated with 150 μL PBS. The mixture is then centrifuged for 2 minutes at 2000 rpm and read using a Wallac Microbeta counter. The reported IC50 values are calculated using a sigmoidal, dose-response curve fit in MDL Assay Explorer.

細胞アッセイ: [2]

細胞株 SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, and MKN-7 cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 48 and 72 hours
実験の流れ Cells are exposed to various concentrations of GDC-0941 for 48, and 72 hours. Proliferation/viability of cells is detected by using the CellTiter-Glo Luminescent Cell Viability Assay. The pAkt (Ser473), cleaved caspase-3, and cleaved PARP are analyzed by western blot. The Caspase-Glo 3/7 assay and the Cell Death Detection ELISAplus assay are used to detect caspase 3/7 activity, and apoptosis, respectively.

動物実験: [2]

動物モデル NCR nude mice implanted with MDA-MB-361.1 cells, and SCID, C.B-17/IcrHsd-Prkdcscid mice implanted subcutaneously with BT474-M1 cells
製剤 Dissolved in 10% DMSO, 5% Tween 20, 85% water
投薬量 ~150 mg/kg/day
投与方法 Oral gavage

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Pictilisib (GDC-0941) SDF
分子量 513.64
化学式

C23H27N7O3S2

CAS No. 957054-30-7
保管 2年-20℃
6月-80℃in solvent
別名 RG7321
溶解度 (25°C) * In vitro DMSO 44 mg/mL (85.66 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 2% DMSO/30% PEG 300/5% Tween 80/ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine

カスタマーフィードバック (7)


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Rating
Source Cancer Res, 2011, 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck
Method Western blot, Immunofluorescence staining, flow cytometry
Cell Lines 1205Lu cells
Concentrations 3 µmol/L
Incubation Time 48 h
Results Combined PI3K and BRAF inhibition increased the level of BIM expression in both Western blot and immunofluorescence studies (Fig. A). Consistent with a role for increased AKT signaling suppressing BIM expression in PTEN- cells, dual BRAF and PI3K inhibition increased nuclear FOXO3a localization in the PTEN- cell lines (Fig. B) and enhanced the level of BIM mRNA (Fig. B). the combination of PLX4720 with the PI3K inhibitor GDC-0941 significantly enhanced the levels of apoptosis observed in PTEN melanoma cell lines compared to either the BRAF or PI3K inhibitor alone (Fig. C). Similar results were also observed in a 3D spheroid assay, where combined PLX4720 (3 µmol/L) and LY294002 (10 µmol/L) treatment prevented the recovery of cell growth observed when melanoma spheroids were treated with either drug alone (Fig. D).

Click to enlarge
Rating
Source J Inves Der, 2010, 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck
Method Western blot
Cell Lines Mel-Juso cells, 518A2 cells
Concentrations 0.05–1 µmol/L
Incubation Time 24 h
Results In addition, GDC-0941 treatment blocked the phosphorylation of AKT protein (S473 and T308) at even lower concentrations than PI-103, and S6 protein phosphorylation was blocked at similar concentrations.

Click to enlarge
Rating
Source J Cell Sci, 2012, 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck
Method Western Blot
Cell Lines NMuMG cells
Concentrations 1 μM
Incubation Time 1 h
Results GDC-0941, a specific inhibitor of the class IA PI3K, similarly blocked the TGF-b-induced Akt(S473) phosphorylation, confirming the role of PI3K in the induction of mTORC2 kinase activity by TGF-β (Fig. C).

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Rating
Source Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck
Method Western blot
Cell Lines Breast cancer cells
Concentrations 0-10 nM
Incubation Time 3 h
Results

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Rating
Source Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck
Method Western blot
Cell Lines T47D cells
Concentrations
Incubation Time 1 h
Results

Click to enlarge
Rating
Source Biochim Biophys Acta, 2012, 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck
Method confocal laser-scanning microscopy
Cell Lines HEK293 cells
Concentrations 1 μM
Incubation Time 30 min
Results Both LY294002 and GDC-0941 markedly attenuated the high-glucose-dependent plasma membrane translocation of DGKδ1, indicating that the event is positively regulated by phosphatidylinositol 3-kinase.

Click to enlarge
Rating
Source Pictilisib (GDC-0941) purchased from Selleck
Method Western blot analysis
Cell Lines MCF-7 cells
Concentrations 0 nM/50 nM/100 nM/400 nM
Incubation Time 24 h
Results GDC-0941 caused a surprising increase in phosphorylation of ERK proteins as well as AKT2 S474. GDC-0941 showed differences in its ability to suppr ess PI3K-dependent signaling across the genotypes. AKT1 mutant cells demonstrated greater residual AKT1 S473 phosphorylation and greater phosphorylation of downstream proteins FOXO 1/3, PRAS40, GSK3β , and p70S6K at equivalent doses of GDC-0941, compared to PIK3CA mutant cells.

文献中の引用 (56)

技術サポート&よくある質問(FAQ)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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