Dabrafenib (GSK2118436)

製品コードS2807

Dabrafenib (GSK2118436)化学構造

分子量(MW):519.56

Dabrafenib (GSK2118436)は一種の突然変異型BRAFV600の特異性的な阻害剤で、無細胞試験でIC50値が0.8nMですが、BRAFV600に作用する効果はB-Raf(wt)とc-Rafに作用する効果より4倍と6倍がそれぞれ高くなります。

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カスタマーフィードバック(5)

  • A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

    Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

  • Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

製品安全説明書

Raf阻害剤の選択性比較

生物活性

製品説明 Dabrafenib (GSK2118436)は一種の突然変異型BRAFV600の特異性的な阻害剤で、無細胞試験でIC50値が0.8nMですが、BRAFV600に作用する効果はB-Raf(wt)とc-Rafに作用する効果より4倍と6倍がそれぞれ高くなります。
靶点
B-Raf (V600E) [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
C-Raf [1]
(Cell-free assay)
0.8 nM 3.2 nM 5.0 nM
In vitro試験

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
M1PydWtqdmG|ZTDBd5NigQ>? M4D4[2lvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDIbZMhfGGpZ3XkJGIuWmGoIG[2NFBGKG23dHHueEBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgbY5{\WO2IHPlcIx{KGOxLXX4dJJme3OrbnegR2REOzdiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[mmxdHnufYxifGWmLV3FT{Bxem:2ZXnuJJBpd3OyaH;yfYxifGmxbjDifUBCdHCqYWPjdoVmdiCjc4PhfUB4cXSqIFnDOVAhd2ZiMD6wNFA4KM7:TR?= MVuyOFkxODZ5Mx?=
SK-MEL-28 NYLmTFFpU2mwYYPlJGF{e2G7 M1HNcVEhcA>? M1TLfmlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIGPLMW1GVC1{ODDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBGWkticHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxPCEQvF2= MYSyOFkxODZ5Mx?=
HepG2 MmnET4lv[XOnIFHzd4F6 MnW0TY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iRWLLJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5yMESg{txO MXSyOFkxODZ5Mx?=
COLO205 NWq3UHd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLwTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRMkC1JINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFch|ryP NVGwPXg2OjR7MEC2O|M>
HepG2 M{DLPWZ2dmO2aX;uJGF{e2G7 MlfMOFUhdWmw Ml30SG1UVw>? M2HRc2lvcGmkaYTpc44hd2ZiQXzrOUBqdiCWR1[tZoV1[S2|dHnteYxifGWmIHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFOvYXSyJJBpd3OyaH;yfYxifGmxbjD0doVifGWmIH\vdkA1PSCvaX7zJJBzcW:{IITvJHRITi2kZYThJJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFYxKG2rboOgZpkhd2S7c4PlfUBjdG:2IIPjZY5v\XJiYX7hcJl{cXNid3n0bEBKSzVyIH;mJFMvPyEQvF2= NHvyR4UzPDlyME[3Ny=>
HFF NYHzfVd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjYNVAh|ryP NEm2NWI4OiCq NFvF[5BFVVOR NXT5WXYyUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIHj1cYFvKEiIRjDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIFKtVoFnKHerdHigTWM2OCCxZjCzJO69VQ>? MVSyN|g1PDB|OB?=
SK-MEL-28 M3nFRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LMeFExKM7:TR?= NEXPd|A4OiCq NFnUWVhFVVOR NH7q[YxKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iU1utUWVNNTJ6IHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yNEOg{txO NXfNR5Q1OjN6NESwN|g>
A375P-F11 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nmTlExKM7:TR?= NH[4OoY4OiCq NEOwbJJFVVOR NVPrd4JnUW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSt[JJqfmWwIFGzO|VRNUZzMTDj[YxtKHC{b3zp[oVz[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEexJO69VQ>? NVfuenZ5OjN6NESwN|g>
MALME-3M NF;pcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW[xNEDPxE1? MVe3NkBp Ml7USG1UVw>? NXHKXoFwUUN3ME2xJI5O NInk[IUzOzh2NECzPC=>
UACC-62 M1jXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETpRZIyOCEQvF2= MnjXO|IhcA>? M3HLR2ROW09? M{jrNWlEPTB;MTDuUS=> Mk\INlM5PDRyM{i=
C32TG NXHXW2F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HO[|ExKM7:TR?= NWD6SWV{PzJiaB?= NWPqN25MTE2VTx?= M{m3U2lEPTB;MTDuUS=> NFPZfpozOzh2NECzPC=>
SK-MEL-1 M2\He2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrMc|YyOCEQvF2= MUW3NkBp NGHT[I5FVVOR NVvoWHF5UUN3ME2yJI5O NGjIOXYzOzh2NECzPC=>
M14 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHQNVAh|ryP M{PoRVczKGh? M2[wRmROW09? M3n6V2lEPTB;MjDuUS=> NEHTfGYzOzh2NECzPC=>
SK-MEL-28 NYDnRW5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzZNVAh|ryP M1jo[lczKGh? MYDEUXNQ NYe0eZl2UUN3ME2zJI5O M2\k[VI{QDR2MEO4
A375 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDyWok5OTBizszN NX\mT|lXPzJiaB?= MXjEUXNQ NH7QdmhKSzVyPUSgcm0> MYWyN|g1PDB|OB?=
DU-4475 MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjhNVAh|ryP MX23NkBp NGHtcVlFVVOR NF;FeWdKSzVyPUWgcm0> NFnUR5ozOzh2NECzPC=>
UACC-257 NVTt[FJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:5U|IyOCEQvF2= MlT0O|IhcA>? MlXkSG1UVw>? NIXZUYdKSzVyPU[gcm0> MoLTNlM5PDRyM{i=
Colo 205 NU\CeXBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nvTVExKM7:TR?= MonIO|IhcA>? NU\nOFJLTE2VTx?= MmW4TWM2OD15IH7N MnXJNlM5PDRyM{i=
SK-MEL-3 NYjMRZgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWO4U5IxOTBizszN M13lfFczKGh? MUfEUXNQ M{LScWlEPTB;NzDuUS=> NXrDSW9LOjN6NESwN|g>
SH-4 NVP4enVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWKxNEDPxE1? NWfzXGY{PzJiaB?= NGfWNVhFVVOR MmjoTWM2OD16IH7N NFO5XpQzOzh2NECzPC=>
A101D NYTIS4d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGntUFYyOCEQvF2= NHXmPYI4OiCq NYGxSHNRTE2VTx?= Mki4TWM2OD17IH7N NXLFeWhSOjN6NESwN|g>
ES-2 NW\ofnRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\HPJkyOCEQvF2= MVe3NkBp NVrxT21FTE2VTx?= NUjTRoJPUUN3ME21N{BvVQ>? MUeyN|g1PDB|OB?=
HT-29 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzx[nFkOTBizszN MVe3NkBp M33SNmROW09? NGqwR29KSzVyPU[2JI5O NWDPPFNZOjN6NESwN|g>
SW1417 NXTZfXBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi3PYRQOTBizszN Mo[zO|IhcA>? Ml\DSG1UVw>? MkPlTWM2OD1zNUigcm0> MUGyN|g1PDB|OB?=
SW872 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXxbXgyOCEQvF2= MkXWO|IhcA>? NYfscIYzTE2VTx?= NVXh[mNVUUN3ME2zO|chdk1? M3HPXFI{QDR2MEO4
RKO Ml\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf0Om4yOCEQvF2= MUG3NkBp MlzkSG1UVw>? NX\LO3hIUUN3ME2yMlUzOiEQvF2= Mn7pNlM5PDRyM{i=
A673 Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOxNEDPxE1? M2LHclczKGh? NHLIOYRFVVOR NWexXYhOUUN3ME2xNEDPxE1? NFTXRVEzOzh2NECzPC=>
GCT MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PYNFExKM7:TR?= MmCyO|IhcA>? NX;vUnByTE2VTx?= M3TpcmlEPTB;MUCg{txO NVzxOYZ5OjN6NESwN|g>
WM-115 NHHSO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn0NVAh|ryP MVi3NkBp MVjEUXNQ Mln3TWM2OD13IH7N MlX3NlM5PDRyM{i=
YUMAC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGL1cYkyOCEQvF2= M37WT|czKGh? M3v4b2ROW09? NVPQNIpHUUN3ME21JI5O MljQNlM5PDRyM{i=
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NCI-H508 MofnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LScFExKM7:TR?= Mli4O|IhcA>? NH\ZUXJFVVOR M4\yS2lEPTB;MUCg{txO MnHoNlM5PDRyM{i=
MDA-MB-231 M3vxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzRNVAh|ryP NVi1S|NnPzJiaB?= NHTadIJFVVOR NVnxfZlZUUN3ME2xNEDPxE1? MXqyN|g1PDB|OB?=
SW756 NGPze2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWOxNEDPxE1? NHfCW|A4OiCq MlPySG1UVw>? NEnEeYhKSzVyPUGwJO69VQ>? MmC0NlM5PDRyM{i=
SW-837 NGW3VZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7IflIyOCEQvF2= MmrLO|IhcA>? M1nNeWROW09? MVnJR|UxRTFyIN88US=> NVfwOoZHOjN6NESwN|g>
UMUC-3 Mor0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXZPVkyOCEQvF2= MnO1O|IhcA>? Mo\rSG1UVw>? MUXJR|UxRTFyIN88US=> MlPRNlM5PDRyM{i=
LS-174T MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzENVAh|ryP MYK3NkBp MlqxSG1UVw>? NUnTW41tUUN3ME2xNEDPxE1? MVOyN|g1PDB|OB?=
A549 NH63UmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfSPXNMOTBizszN MYq3NkBp M13ud2ROW09? MW\JR|UxRTFyIN88US=> MYKyN|g1PDB|OB?=
SHP-77 Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3kfppmOTBizszN MnrGO|IhcA>? NFXQe|FFVVOR MWPJR|UxRTFyIN88US=> MmL0NlM5PDRyM{i=
SW480 M4m2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWxSnI6OTBizszN MoLIO|IhcA>? NX\XXYg2TE2VTx?= NVO4U5FLUUN3ME2xNEDPxE1? MYKyN|g1PDB|OB?=
DLD-1 M{KyeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPRNVAh|ryP NIX4[Io4OiCq MVjEUXNQ NFLic3ZKSzVyPUGwJO69VQ>? NFHvNFczOzh2NECzPC=>
HCT-116 NH\1VIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq1SlZ4OTBizszN NHzyXVc4OiCq NWLXR|RsTE2VTx?= NGn0bZNKSzVyPUGwJO69VQ>? MXqyN|g1PDB|OB?=
NCI-H747 NHe1cIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHyUncyOCEQvF2= MlG1O|IhcA>? MWHEUXNQ MlXmTWM2OD1zMDFOwG0> MoD6NlM5PDRyM{i=
T-84 MoDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXJT3YyOCEQvF2= NWnadFlwPzJiaB?= M37UV2ROW09? Mm\iTWM2OD1zMDFOwG0> M2nCRlI{QDR2MEO4
NCI-H460 M{\UZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHRWY4yOCEQvF2= MX63NkBp MVfEUXNQ NWXnZ41FUUN3ME2xNEDPxE1? MoXZNlM5PDRyM{i=
Calu-6 MofnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHEbI8yOCEQvF2= M1jKTFczKGh? MWfEUXNQ NH3kdZVKSzVyPUGwJO69VQ>? Mo\kNlM5PDRyM{i=
HCC-2998 NVLkPItlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTsNVAh|ryP MlXDO|IhcA>? NUDsO3M1TE2VTx?= NYq3TokyUUN3ME2xNEDPxE1? M3jXflI{QDR2MEO4
LS1034 M2TlUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnrfmUyOCEQvF2= NEGzWFY4OiCq MWrEUXNQ NIr4c5JKSzVyPUGwJO69VQ>? M1;yR|I{QDR2MEO4
CHP-212 NUfjSG1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvPNVAh|ryP NEjo[5k4OiCq MoDhSG1UVw>? NWXmWItRUUN3ME2xNEDPxE1? MnnSNlM5PDRyM{i=
SK-N-AS NFvne5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G3Z|ExKM7:TR?= NWDWZlgzPzJiaB?= Mom0SG1UVw>? NEOxZWdKSzVyPUGwJO69VQ>? NIPVNo8zOzh2NECzPC=>
BFTC-905 M2LaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1yzdlExKM7:TR?= MXG3NkBp MknrSG1UVw>? NGHYNG1KSzVyPUGwJO69VQ>? NIe2O3EzOzh2NECzPC=>
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RPMI-8226 MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXqxNEDPxE1? NHz4VVg4OiCq M{TnU2ROW09? MW\JR|UxRTJ4MzDuUS=> NWDKTpBFOjN6NESwN|g>
BC-3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DhTFExKM7:TR?= MnHkO|IhcA>? MXnEUXNQ Moi3TWM2OD1{N{egcm0> NHj0Nm0zOzh2NECzPC=>
ACHN MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDwNVAh|ryP M3ezSVczKGh? M4nYVWROW09? NGj2TnBKSzVyPUK5OEBvVQ>? NIPocZkzOzh2NECzPC=>
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SK-MES-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLUXHEyOCEQvF2= M1;pflczKGh? NHzEZZpFVVOR Mli1TWM2OD1|Mkmgcm0> MnL1NlM5PDRyM{i=
CESS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO4e41WOTBizszN MnW3O|IhcA>? M4rH[GROW09? NYTqdJFCUUN3ME20PVchdk1? M4XNOFI{QDR2MEO4
H4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17TWFExKM7:TR?= MnrqO|IhcA>? MUDEUXNQ NUL3UJpPUUN3ME22NVkhdk1? MUCyN|g1PDB|OB?=
BC-1 MmPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfXUpIyOCEQvF2= NVXaXIg{PzJiaB?= MlfySG1UVw>? MXXJR|UxRTdyNDDuUS=> MYCyN|g1PDB|OB?=
DB MojOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF24dXoyOCEQvF2= NIL0S5A4OiCq M{SzSmROW09? NGL5Z|JKSzVyPUi3N{BvVQ>? NH\FZlkzOzh2NECzPC=>
RPMI-6666 MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\1WYoyOCEQvF2= M3mzbVczKGh? M1O1WGROW09? NF3CNllKSzVyPUmyPEBvVQ>? NFH6eGQzOzh2NECzPC=>
MC/CAR NGDtem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrMdXJEOTBizszN NXnVfWFNPzJiaB?= NFToTnpFVVOR NWroXFdkUUN3ME2xMlAxOiEQvF2= NV[4Z41{OjN6NESwN|g>
SNU-1 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzaZWNtOTBizszN NVvUdG1CPzJiaB?= NXnoeJlYTE2VTx?= MYLJR|UxRTFwNUCxJO69VQ>? NVGxWllHOjN6NESwN|g>
CEM/C1 Mke0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O0dlExKM7:TR?= MYK3NkBp NIPaUHdFVVOR NVfzTmZxUUN3ME2xMlc4OyEQvF2= MnjkNlM5PDRyM{i=
GDM-1 MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[1NVAh|ryP M2fJb|czKGh? MWHEUXNQ NXrkfplFUUN3ME2xMlk6PyEQvF2= Mm\RNlM5PDRyM{i=
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CAL-27 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO0NVAh|ryP MlP6O|IhcA>? NET3XldFVVOR MXzJR|UxRTFyIN88US=> M1y0PFI{QDR2MEO4
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DU-145 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXyxNEDPxE1? M2LCNlczKGh? NGnCd2tFVVOR MYrJR|UxRTFyIN88US=> NFfmbXgzOzh2NECzPC=>
EB-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLVNVAh|ryP NVHmVnVbPzJiaB?= MUfEUXNQ NEj2PGJKSzVyPUGwJO69VQ>? M1X4TlI{QDR2MEO4
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MDA-MB-468 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNEDPxE1? Mo\rO|IhcA>? NFfFe|FFVVOR MlfGTWM2OD1zMDFOwG0> M4\iSVI{QDR2MEO4
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NCI-H146 M{myd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j4ZlExKM7:TR?= MkDxO|IhcA>? NF7YUIdFVVOR Mnv1TWM2OD1zMDFOwG0> NFjxOpozOzh2NECzPC=>
NCI-H157 NUDlRlVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3vNVAh|ryP MmjBO|IhcA>? M1;nTWROW09? MXjJR|UxRTFyIN88US=> NEHRW4szOzh2NECzPC=>
NCI-H187 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXBNVAh|ryP NFfuUZc4OiCq NFHKSo5FVVOR M3n3ZmlEPTB;MUCg{txO NGfuTpEzOzh2NECzPC=>
NCI-H209 M3HqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq0OoUyOCEQvF2= NXnENFE1PzJiaB?= MUfEUXNQ NIrqT5JKSzVyPUGwJO69VQ>? MoDJNlM5PDRyM{i=
NCI-H226 M1nrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOxNEDPxE1? NGi1UoI4OiCq M1jLXGROW09? NVvLPHlSUUN3ME2xNEDPxE1? NVvFPG9HOjN6NESwN|g>
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NCI-H322 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXyxNEDPxE1? MUe3NkBp M3\k[mROW09? NW\rXpJiUUN3ME2xNEDPxE1? MUeyN|g1PDB|OB?=
NCI-H358 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLnfoh4OTBizszN MXW3NkBp NF3s[lRFVVOR MmXmTWM2OD1zMDFOwG0> NH7GfoYzOzh2NECzPC=>
NCI-H520 NXjSb4FnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;HU|ExKM7:TR?= Ml\CO|IhcA>? NVzLV5pkTE2VTx?= M{THbGlEPTB;MUCg{txO M3y5S|I{QDR2MEO4
NCI-H526 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPlNVAh|ryP MXm3NkBp NIDMU5ZFVVOR MYnJR|UxRTFyIN88US=> MWKyN|g1PDB|OB?=
NCI-H630 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFOyZoIyOCEQvF2= MmnZO|IhcA>? M{XPb2ROW09? M{fEXmlEPTB;MUCg{txO M1LkblI{QDR2MEO4
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NCI-H1563 M{DzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki4NVAh|ryP NYDpe|UzPzJiaB?= NV[wb4VzTE2VTx?= NGrJcnpKSzVyPUGwJO69VQ>? NVzwRYNrOjN6NESwN|g>
NCI-H1792 MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV6xNEDPxE1? MXm3NkBp MVvEUXNQ MonlTWM2OD1zMDFOwG0> M4KySVI{QDR2MEO4
NCI-H2030 NVjoUXU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP6NVAh|ryP NYfNSYFHPzJiaB?= NGL2dGVFVVOR MUnJR|UxRTFyIN88US=> MVyyN|g1PDB|OB?=
NCI-H2052 NIfHSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfscGFoOTBizszN NGr4[ow4OiCq MVnEUXNQ NUjPSIM5UUN3ME2xNEDPxE1? Ml\kNlM5PDRyM{i=
NCI-H2122 MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjwNVAh|ryP MYq3NkBp NG\mOIFFVVOR MYTJR|UxRTFyIN88US=> M4TafVI{QDR2MEO4
NCI-H2228 M{nyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LrdFExKM7:TR?= MYe3NkBp Mon4SG1UVw>? MXHJR|UxRTFyIN88US=> NXO1dnV1OjN6NESwN|g>
OE-19 NHvwfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi3bWYyOCEQvF2= MWS3NkBp NHLFbotFVVOR M{HXUGlEPTB;MUCg{txO NVrSSXB5OjN6NESwN|g>
OE-21 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW5UIYyOCEQvF2= NIjWO2k4OiCq MojaSG1UVw>? NHTjbnRKSzVyPUGwJO69VQ>? NVvwTIVMOjN6NESwN|g>
OE-33 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1KxNFExKM7:TR?= NIm4PVE4OiCq MkLRSG1UVw>? MWnJR|UxRTFyIN88US=> MYeyN|g1PDB|OB?=
OVCAR-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\tOmZDOTBizszN NHPaeWw4OiCq M2K5VmROW09? MoXTTWM2OD1zMDFOwG0> MVWyN|g1PDB|OB?=
OVCAR-4 MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jpeFExKM7:TR?= Mn;GO|IhcA>? NHrae4lFVVOR NEHpWJpKSzVyPUGwJO69VQ>? NYXGWZFYOjN6NESwN|g>
OVCAR-5 NYjvSXhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXqxNEDPxE1? NX3kO3UxPzJiaB?= M{Dsc2ROW09? M1LGc2lEPTB;MUCg{txO MnW1NlM5PDRyM{i=
P3HR-1 NFnWWllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHjepEyOCEQvF2= NVrXO3JvPzJiaB?= NXLSbXRNTE2VTx?= NVX5foV4UUN3ME2xNEDPxE1? M{XxZVI{QDR2MEO4
PC-3 NXPjS2FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3GwXlExKM7:TR?= NHzRW2o4OiCq NV;E[XRFTE2VTx?= MmHyTWM2OD1zMDFOwG0> Mlf0NlM5PDRyM{i=
Raji NYnWZXl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7INVAh|ryP M3XucVczKGh? MmDYSG1UVw>? MXnJR|UxRTFyIN88US=> NUjDcI94OjN6NESwN|g>
RD M3HNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXWxNEDPxE1? M4fqUlczKGh? NVnOSHJKTE2VTx?= M4nGc2lEPTB;MUCg{txO NGLMOZczOzh2NECzPC=>
RD-ES NVnLeYxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK0NVAh|ryP M3i2clczKGh? MYfEUXNQ MljITWM2OD1zMDFOwG0> M37CXVI{QDR2MEO4
RL NXvKUGRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjDNVAh|ryP NWDsV4ZsPzJiaB?= NHnVWYJFVVOR NULZPZJQUUN3ME2xNEDPxE1? M4POV|I{QDR2MEO4
SaOS2 MoXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvHNVAh|ryP MX63NkBp MXTEUXNQ MYjJR|UxRTFyIN88US=> NHHPT|QzOzh2NECzPC=>
SCC-9 NVq3NIZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TBSVExKM7:TR?= NWTIWoxbPzJiaB?= MnHNSG1UVw>? NIrkTIlKSzVyPUGwJO69VQ>? NIPweJMzOzh2NECzPC=>
SCC-12 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTtO5VYOTBizszN NX:4d3RmPzJiaB?= Mn\mSG1UVw>? NH2wXldKSzVyPUGwJO69VQ>? NFzYO2EzOzh2NECzPC=>
SCC-13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXixNEDPxE1? NVfYfWpLPzJiaB?= NYjlZm5STE2VTx?= NV\3bIlrUUN3ME2xNEDPxE1? M2\md|I{QDR2MEO4
SCC-15 Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC3NVAh|ryP M2Ozb|czKGh? NUjPRYo2TE2VTx?= NXrYPGYzUUN3ME2xNEDPxE1? MoL5NlM5PDRyM{i=
SCC-25 Ml7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;QNVAh|ryP MlPSO|IhcA>? MlLPSG1UVw>? NITCd3hKSzVyPUGwJO69VQ>? Mo\GNlM5PDRyM{i=
SCLC-3 NFvyUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrNfZg6OTBizszN MYC3NkBp MWPEUXNQ MnPBTWM2OD1zMDFOwG0> MnLZNlM5PDRyM{i=
SF-268 NWT3WpQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXDXoJxOTBizszN NVvDSoE1PzJiaB?= M1XBc2ROW09? MV;JR|UxRTFyIN88US=> MofmNlM5PDRyM{i=
SF-295 NV3vNYpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;XNVAh|ryP MljzO|IhcA>? MWXEUXNQ M2ezTWlEPTB;MUCg{txO MljFNlM5PDRyM{i=
SJRH30 NHPkT4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq1fpp4OTBizszN M1;GT|czKGh? NV3QW|Q{TE2VTx?= M3m0d2lEPTB;MUCg{txO NViwbogxOjN6NESwN|g>
SK-BR-3 Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LqRlExKM7:TR?= M2HS[lczKGh? NF\Y[4pFVVOR NIn5XpJKSzVyPUGwJO69VQ>? NFzyeIozOzh2NECzPC=>
SK-LMS-1 MofmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3hNVAh|ryP M3X0SFczKGh? M3:wUWROW09? MYfJR|UxRTFyIN88US=> NFjscG4zOzh2NECzPC=>
SK-N-DZ NWPTdI9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nufFExKM7:TR?= M2\qW|czKGh? NWWydFRnTE2VTx?= MYTJR|UxRTFyIN88US=> MU[yN|g1PDB|OB?=
SK-N-F1 NIGxVIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqyVYMyOCEQvF2= NIrnUXc4OiCq M2PMPGROW09? M2DTU2lEPTB;MUCg{txO NWr1TGxyOjN6NESwN|g>
SKOV-3 NGDwUVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLG[40yOCEQvF2= NFrjbXI4OiCq NYnJfnE6TE2VTx?= NXzOW3kxUUN3ME2xNEDPxE1? NX\KT4VkOjN6NESwN|g>
SK-UT-1 NU[zRVl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS0NVAh|ryP NWDtcmFyPzJiaB?= MkDTSG1UVw>? NFvvSZZKSzVyPUGwJO69VQ>? Mlm2NlM5PDRyM{i=
SN12C NVvl[mFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHYZ4syOCEQvF2= MV23NkBp MmDoSG1UVw>? NHjXOHdKSzVyPUGwJO69VQ>? NFT2SYozOzh2NECzPC=>
SNB-19 M1T2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYWwb2M2OTBizszN NEjKOWY4OiCq M1Xsd2ROW09? NEDLdYlKSzVyPUGwJO69VQ>? MVOyN|g1PDB|OB?=
SNU-5 NFjpPZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVGxNEDPxE1? NF7WbXM4OiCq MVHEUXNQ MYjJR|UxRTFyIN88US=> NWq5UVJEOjN6NESwN|g>
SNU-16 NGHsOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrJfIduOTBizszN MYK3NkBp MYjEUXNQ MXXJR|UxRTFyIN88US=> NX3mdWM6OjN6NESwN|g>
SNU-398 MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHJNXc{OTBizszN MXq3NkBp M{TxWmROW09? MUHJR|UxRTFyIN88US=> MViyN|g1PDB|OB?=
SNU-449 MoTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPWZZkyOCEQvF2= M3TqclczKGh? M3zNSmROW09? NYL1RXJZUUN3ME2xNEDPxE1? M3S3SFI{QDR2MEO4
SR MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XabVExKM7:TR?= NITWeIw4OiCq NXOzdlZMTE2VTx?= NUXmdWFvUUN3ME2xNEDPxE1? MYKyN|g1PDB|OB?=
ST486 NUPsd|hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr0V4cyOCEQvF2= NIf5dWg4OiCq MUjEUXNQ MknITWM2OD1zMDFOwG0> NVmzfIV2OjN6NESwN|g>
SW579 NUnnWG4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7PfZVUOTBizszN M{nRclczKGh? M1;POmROW09? MYrJR|UxRTFyIN88US=> M3:yUFI{QDR2MEO4
SW684 M{XIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDVbGwyOCEQvF2= MkO4O|IhcA>? M3y0XmROW09? NFTj[XBKSzVyPUGwJO69VQ>? M4jmWlI{QDR2MEO4
SW-780 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1G5UlExKM7:TR?= NUHBc|RLPzJiaB?= NGDaW4hFVVOR NEfFUlRKSzVyPUGwJO69VQ>? MUGyN|g1PDB|OB?=
SW900 NF31NlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fUd|ExKM7:TR?= NWi1dY9nPzJiaB?= M3Pq[2ROW09? Mnf0TWM2OD1zMDFOwG0> NFrMcJEzOzh2NECzPC=>
SW1088 M{XISWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlftNVAh|ryP M{XCT|czKGh? NFO2dIVFVVOR MUPJR|UxRTFyIN88US=> MnvvNlM5PDRyM{i=
SW1463 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXxNVAh|ryP NIqzWWM4OiCq NX;uOZVsTE2VTx?= MVLJR|UxRTFyIN88US=> NWLlXHdnOjN6NESwN|g>
SW1990 NFv6WnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXKxNEDPxE1? NEi1S5k4OiCq MXHEUXNQ M2jnemlEPTB;MUCg{txO MkT5NlM5PDRyM{i=
T47D NXzQOoJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;KNVAh|ryP M1z0UFczKGh? NEfFcYRFVVOR MoL3TWM2OD1zMDFOwG0> M1zWTFI{QDR2MEO4
TE381.T NH;aS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rrc|ExKM7:TR?= NUT6OYlxPzJiaB?= NH;MfI9FVVOR NFvKSWVKSzVyPUGwJO69VQ>? MmnyNlM5PDRyM{i=
TK-10 Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[5foUyOCEQvF2= MV63NkBp NFHVfphFVVOR M{XxfGlEPTB;MUCg{txO MYmyN|g1PDB|OB?=
U2OS NETOd2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P4XlExKM7:TR?= NFKxWYk4OiCq NGHoSVlFVVOR MVTJR|UxRTFyIN88US=> M{nyelI{QDR2MEO4
U251 M4HoN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXGxNEDPxE1? MVe3NkBp Mn7JSG1UVw>? M{\hPGlEPTB;MUCg{txO MWeyN|g1PDB|OB?=
UACC-812 MmrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTDNVAh|ryP MV63NkBp NEi4SoZFVVOR MVPJR|UxRTFyIN88US=> MV2yN|g1PDB|OB?=
YAPC NUXSUnNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWWxNEDPxE1? NGLIVlQ4OiCq NIjOeVJFVVOR MUfJR|UxRTFyIN88US=> NWPZPIl2OjN6NESwN|g>
ZR-75-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:1NVAh|ryP NWDsR4xRPzJiaB?= NHXjcWZFVVOR MkfJTWM2OD1zMDFOwG0> Mn3jNlM5PDRyM{i=
A375 NUW2eXFsTnWwY4Tpc44h[XO|YYm= NFu4TIMyNjJizszN M3fUWVQhcA>? NVKwcZBtTE2VTx?= M2DTOWlvcGmkaYTpc44hd2ZicHjvd5Bpd3K7bHH0bY9vKG:oIF3FT{whTVKNLDDhcoQhWz[S M4\Od|IzOzh7NEex
YUSIT1 MV3GeY5kfGmxbjDhd5NigQ>? NFHzV5RFVVOR Mmq2doVlfWOnZDDz[Y5{cXSrdnn0fUB4cXSqIFnDOVAhRiByLkWg{txO MV6yNlM5QTR5MR?=
MeWo NVTOeXZzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1HoOGROW09? NYXQbI1[UUN3MDC9JFk5PyCwTR?= MnK3NlYxOTh3MkS=
WiDr NX;OT2FuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHnjdIJFVVOR MUTJR|UxKD1iN{[gcm0> MnSwNlYxOTh3MkS=
Colo-205 MnSzSpVv[3Srb36gZZN{[Xl? Mli5NUDPxE1? NXjzWlNWPCCm NEXYe5VFVVOR MlfFTY5lfWOnZDDhJIhq\2iueTDjc41x[XKjYnzlJINwdXCjY4Tpc44heGinbn;0fZBm MV:yOVM5OTF3Mh?=
RBW-1 NFHNco1HfW6ldHnvckBie3OjeR?= NWi0SpNZOSEQvF2= NFX6[YlFVVOR NUHsW|lJVm9icnXkeYN1cW:wIH;mJG1mcyBzL{KgdIhwe3Cqb4L5cIF1cW:w NIm5NnYzPDh6NU[5NC=>
RBO-1 M1fzXWZ2dmO2aX;uJIF{e2G7 MlTiNUDPxE1? NWTrdYtOTE2VTx?= MWDJcohq[mm2aX;uJI9nKE2nazCxM|IheGixc4Doc5J6dGG2aX;u MXKyOFg5PTZ7MB?=
RBO-2 NYW3c4l7TnWwY4Tpc44h[XO|YYm= MXSxJO69VQ>? MVHEUXNQ NUfnd3pEUW6qaXLpeIlwdiCxZjCgUYVsKDFxMjDwbI9{eGixconsZZRqd25? MmjhNlQ5QDV4OUC=
RBOW MYXGeY5kfGmxbjDhd5NigQ>? NHnFWFYyKM7:TR?= M4jvTGROW09? MonKTY5pcWKrdHnvckBw\iBiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> MYCyOFg5PTZ7MB?=
M257 NGnQVXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\yc3NZOTByIH7N MUK3NkBp M3W3WGRw\XNibn;0JIlvcGmkaYSgdJJwdGmoZYLheIlwdiCxZjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= NHzoboszOzNzN{S0Oi=>
LCP MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvqU2h1OTByIH7N NIjPOmo4OiCq NFSwdm1KdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v M3rCUVI{OzF5NES2
WM266 NYHuPGZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXyxNFAhdk1? Ml\wO|IhcA>? M3jKUGlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCZTUK2OkBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCxSEBufXSjboTheIlwdg>? NVjDeFRGOjN|MUe0OFY>
M257 NFHiWHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;yNVAxKG6P MkXqO|IhcA>? NILJUpVFd2W|IH7veEBqdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= NWLwbXhLOjN|MUe0OFY>
LCP NX6zfoh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmC4NVAxKG6P MXW3NkBp MUjJcohq[mm2IFXST|EuOiCyaH;zdIhwenmuYYTpc44hcW5iTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v MUSyN|MyPzR2Nh?=
WM266 M{n0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjjVJIyODBibl2= NVfqRW9bPzJiaB?= MkGxTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIGfNNlY3KGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFBFKG23dHHueIF1cW:w NUTjTmo{OjN|MUe0OFY>

... Click to View More Cell Line Experimental Data

In vivo試験 Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

プロトコル(参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
体内 30% PEG400+0.5% Tween80+5% propylene glycol 8 mg/mL

* <1 mg/mlは製品が微弱に溶解する或いは溶解しないことを示します。
* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 519.56
化学式

C23H20F3N5O2S2

CAS No. 1195765-45-7
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01723202 Active, not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7, 2012 Phase 2
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis October 2017 Phase 2
NCT02447939 Withdrawn Melanoma GlaxoSmithKline May 2017 Phase 1
NCT02967692 Not yet recruiting Melanoma Novartis Pharmaceuticals|Novartis February 2017 Phase 3
NCT02858921 Not yet recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis February 2017 Phase 2
NCT03026517 Recruiting Melanoma Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University January 2017 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

Raf信号経路図

Raf Inhibitors with Unique Features

相関Raf製品

Tags: Dabrafenib (GSK2118436)を買う | Dabrafenib (GSK2118436) ic50 | Dabrafenib (GSK2118436)供給者 | Dabrafenib (GSK2118436)を購入する | Dabrafenib (GSK2118436)費用 | Dabrafenib (GSK2118436)生産者 | オーダーDabrafenib (GSK2118436) | Dabrafenib (GSK2118436)化学構造 | Dabrafenib (GSK2118436)分子量 | Dabrafenib (GSK2118436)代理店
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID