Dabrafenib (GSK2118436)

Dabrafenib(GSK2118436)は、B-Rafの強力なATP競争的阻害剤で、 B-Raf、 B-RafV600E 、c-Rafに作用する時、 IC50 がそれぞれ 3.2 nM、 0.8 nM 、 5.0 nMです。

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Dabrafenib (GSK2118436) 化学構造
分子量: 519.56

高品質保証

カスタマーフィードバック(4)

MSDS

製品説明

  • Compare Raf Inhibitors
    Raf製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Dabrafenib(GSK2118436)は、B-Rafの強力なATP競争的阻害剤で、 B-Raf、 B-RafV600E 、c-Rafに作用する時、 IC50 がそれぞれ 3.2 nM、 0.8 nM 、 5.0 nMです。
ターゲット B-raf B-RafV600E c-Raf
IC50 3.2 nM 0.8 nM 5.0 nM [1]
In vitro試験 Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NWnORXg{U2mwYYPlJGF{e2G7 M{TrV2lvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDIbZMhfGGpZ3XkJGIuWmGoIG[2NFBGKG23dHHueEBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgbY5{\WO2IHPlcIx{KGOxLXX4dJJme3OrbnegR2REOzdiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[mmxdHnufYxifGWmLV3FT{Bxem:2ZXnuJJBpd3OyaH;yfYxifGmxbjDifUBCdHCqYWPjdoVmdiCjc4PhfUB4cXSqIFnDOVAhd2ZiMD6wNFA4KM7:TR?= MljONlQ6ODB4N{O=
SK-MEL-28 NFjPW2FMcW6jc3WgRZN{[Xl? MlKyNUBp M13mdmlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIGPLMW1GVC1{ODDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBGWkticHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxPCEQvF2= MkfvNlQ6ODB4N{O=
HepG2 NFzLVWdMcW6jc3WgRZN{[Xl? M3vaWmlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC0JO69VQ>? MUOyOFkxODZ5Mx?=
COLO205 M3PiXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHUWHpKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:yNFUh[2WubDDwdo9tcW[ncnH0bY9vKHerdHigTWM2OCCxZjCwMlAxPyEQvF2= NEPBNZEzPDlyME[3Ny=>
HepG2 MonYSpVv[3Srb36gRZN{[Xl? NXfwdINjPDVibXnu MlfySG1UVw>? MlXiTY5pcWKrdHnvckBw\iCDbHu1JIlvKFSJRj3i[ZRiNXO2aX31cIF1\WRiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hW22jZEKgdIhwe3Cqb4L5cIF1cW:wIITy[YF1\WRiZn;yJFQ2KG2rboOgdJJqd3JidH:gWGdHNWKndHGgd5RqdXWuYYTpc44hdWWjc4Xy[YQh[W[2ZYKgOlAhdWmwczDifUBw\Hm|c3X5JIJtd3Ric3Phco5meiCjbnHsfZNqeyC5aYToJGlEPTBib3[gN{44KM7:TR?= Mn:2NlQ6ODB4N{O=
HFF M4\uZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrzWmIyOCEQvF2= NYDCTI9vPzJiaB?= NU\iO3pzTE2VTx?= MlXqTY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKGi3bXHuJGhHTiClZXzsd{Bp[XKkb4Lpcochf2muZDD0fZBmKEJvUnHmJJdqfGhiSVO1NEBw\iB|IN88US=> NXHBUolxOjN6NESwN|g>
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MALME-3M MnG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHiWHdlOTBizszN NIrGfYM4OiCq NIHrdWFFVVOR M1raWWlEPTB;MTDuUS=> M17x[FI{QDR2MEO4
UACC-62 NHnPWFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{C2eVExKM7:TR?= NXPFW3JKPzJiaB?= MVnEUXNQ NWPpZmdlUUN3ME2xJI5O NF7YTIozOzh2NECzPC=>
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SK-MEL-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zMUVExKM7:TR?= MWC3NkBp MXfEUXNQ MnixTWM2OD1{IH7N NGC4R4QzOzh2NECzPC=>
M14 NGTYTVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUCxNEDPxE1? M3q0XFczKGh? M1vqOmROW09? MY\JR|UxRTJibl2= Mke4NlM5PDRyM{i=
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UACC-257 NVHDPJdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSxNEDPxE1? M2X2XVczKGh? NUPBVlhYTE2VTx?= MXXJR|UxRTZibl2= M4nib|I{QDR2MEO4
Colo 205 NXfx[Y1kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\PNVAh|ryP NEPJT3o4OiCq M{\aR2ROW09? Mn[4TWM2OD15IH7N MkHnNlM5PDRyM{i=
SK-MEL-3 NFvreIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTwNVAh|ryP MX23NkBp M4HXcGROW09? MnPjTWM2OD15IH7N MYWyN|g1PDB|OB?=
SH-4 NH7Pe3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfsdVcyOCEQvF2= MWC3NkBp MkfXSG1UVw>? Mlr6TWM2OD16IH7N MonHNlM5PDRyM{i=
A101D MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;TUWIyOCEQvF2= M1n5fVczKGh? NXrTOHh4TE2VTx?= MYPJR|UxRTlibl2= NU\sNlQzOjN6NESwN|g>
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HT-29 NGW2XFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVWxNEDPxE1? M3:wRlczKGh? M1PxR2ROW09? MnTJTWM2OD14NjDuUS=> NEfhVWgzOzh2NECzPC=>
SW1417 NY\hOohiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\nW|ExKM7:TR?= NV3neGNZPzJiaB?= MXHEUXNQ NWLwfXVUUUN3ME2xOVghdk1? NGDYfoQzOzh2NECzPC=>
SW872 MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PydFExKM7:TR?= MVe3NkBp MknZSG1UVw>? M1T6O2lEPTB;M{e3JI5O NInSSJozOzh2NECzPC=>
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GCT NYDwUHhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D0XVExKM7:TR?= MVO3NkBp NHfIdZlFVVOR MUTJR|UxRTFyIN88US=> NWLkbHc5OjN6NESwN|g>
WM-115 NVP4TGtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLINVAh|ryP NFfZS3Y4OiCq NF\WOJZFVVOR MYrJR|UxRTVibl2= NV71THh1OjN6NESwN|g>
YUMAC NGfzd5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly1NVAh|ryP NGC2Z|U4OiCq Ml\vSG1UVw>? NEGzXGFKSzVyPUWgcm0> NHTwXI0zOzh2NECzPC=>
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NCI-H508 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVSxNEDPxE1? NVyzW2N2PzJiaB?= NIn0XGRFVVOR M1TORmlEPTB;MUCg{txO MYOyN|g1PDB|OB?=
MDA-MB-231 M{izN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[y[IMyOCEQvF2= MkXUO|IhcA>? MV;EUXNQ MV\JR|UxRTFyIN88US=> NG\ydowzOzh2NECzPC=>
SW756 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjoWpIyOCEQvF2= NEDnc4Y4OiCq M3HwT2ROW09? Mme1TWM2OD1zMDFOwG0> MUCyN|g1PDB|OB?=
SW-837 M{P6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nCR|ExKM7:TR?= NYLxVGExPzJiaB?= NHLvSGtFVVOR MoHhTWM2OD1zMDFOwG0> Mm\SNlM5PDRyM{i=
UMUC-3 M4fTZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\GTlJ3OTBizszN NHLGN2E4OiCq MYPEUXNQ NYnOXnE1UUN3ME2xNEDPxE1? M4rXeVI{QDR2MEO4
LS-174T MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTYRVlPOTBizszN MVK3NkBp MoLPSG1UVw>? M2myT2lEPTB;MUCg{txO M1nzcVI{QDR2MEO4
A549 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYSxNEDPxE1? MmrIO|IhcA>? M2r1WGROW09? NWjrc5hMUUN3ME2xNEDPxE1? MYKyN|g1PDB|OB?=
SHP-77 MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVuxNEDPxE1? NETRenY4OiCq M{nhdGROW09? NE\xc2hKSzVyPUGwJO69VQ>? MnjjNlM5PDRyM{i=
SW480 NHG0eI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzuNVAh|ryP MYe3NkBp Mlv6SG1UVw>? NWW5R|BuUUN3ME2xNEDPxE1? NGDuZnMzOzh2NECzPC=>
DLD-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fD[VExKM7:TR?= NY\lO3I6PzJiaB?= M1n6XGROW09? MmPnTWM2OD1zMDFOwG0> NWX2dVI6OjN6NESwN|g>
HCT-116 MmfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrZdHkyOCEQvF2= MWW3NkBp MVXEUXNQ M4TKeGlEPTB;MUCg{txO NXnlepE6OjN6NESwN|g>
NCI-H747 M4T0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\yW3dxOTBizszN NWTFWZFbPzJiaB?= NYm5WVN5TE2VTx?= NHH1VohKSzVyPUGwJO69VQ>? M3f2NVI{QDR2MEO4
T-84 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW[xNEDPxE1? NYDLbJVsPzJiaB?= NHnYO4tFVVOR NXj2WHF5UUN3ME2xNEDPxE1? NV7FbJV4OjN6NESwN|g>
NCI-H460 NHrwUZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3KxSlExKM7:TR?= NYHEOoJRPzJiaB?= NHfQVmJFVVOR Ml\1TWM2OD1zMDFOwG0> MUeyN|g1PDB|OB?=
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HCC-2998 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTXeo5YOTBizszN NYHVc4kzPzJiaB?= NYq0XW5DTE2VTx?= MVrJR|UxRTFyIN88US=> NHXzSFYzOzh2NECzPC=>
LS1034 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\VcpNIOTBizszN MV23NkBp MUPEUXNQ NV3Ienk{UUN3ME2xNEDPxE1? MnLXNlM5PDRyM{i=
CHP-212 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTodnoyOCEQvF2= MWe3NkBp MUDEUXNQ MVTJR|UxRTFyIN88US=> MlfnNlM5PDRyM{i=
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BFTC-905 M{DYVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV[xNEDPxE1? MlPTO|IhcA>? M3:wR2ROW09? M{[2RWlEPTB;MUCg{txO Mnm1NlM5PDRyM{i=
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BC-3 Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXyxNEDPxE1? MlLFO|IhcA>? MYfEUXNQ M4PHcGlEPTB;Mke3JI5O M2DHNVI{QDR2MEO4
ACHN NETPcJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP5NVAh|ryP MlvNO|IhcA>? MlnFSG1UVw>? NInBdWVKSzVyPUK5OEBvVQ>? NVz4SJp1OjN6NESwN|g>
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RPMI-6666 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[xNEDPxE1? M3nOflczKGh? M3HYW2ROW09? NG[yZ45KSzVyPUmyPEBvVQ>? NHOwe|kzOzh2NECzPC=>
MC/CAR NEXIfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDxVG9ZOTBizszN MV:3NkBp MlTlSG1UVw>? NIX0do1KSzVyPUGuNFAzKM7:TR?= MX:yN|g1PDB|OB?=
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HL-60 NGjVbHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTLXoMyOCEQvF2= MlzqO|IhcA>? MkHsSG1UVw>? M1nHZWlEPTB;Mj6xO|gh|ryP NEXaUnkzOzh2NECzPC=>
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MES-SA NE\GOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLQNVAh|ryP MnPMO|IhcA>? NYPkSVdrTE2VTx?= NYnBN4NkUUN3ME22Mlk5QSEQvF2= MXmyN|g1PDB|OB?=
22Rv1 MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2faW|ExKM7:TR?= M2T2SVczKGh? MYnEUXNQ MULJR|UxRTFyIN88US=> MmHuNlM5PDRyM{i=
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786-O MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPrPGZGOTBizszN MmjCO|IhcA>? NWHuZppbTE2VTx?= MU\JR|UxRTFyIN88US=> M1rsdVI{QDR2MEO4
A172 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL1XI41OTBizszN NUnVUFlXPzJiaB?= M2jre2ROW09? NGXRbpBKSzVyPUGwJO69VQ>? NYD2NGpQOjN6NESwN|g>
A204 Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nDZ|ExKM7:TR?= M12wbFczKGh? M1fMdGROW09? MYDJR|UxRTFyIN88US=> M1XHT|I{QDR2MEO4
A427 NFfNZm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DqS|ExKM7:TR?= NWGyWmJUPzJiaB?= NITXcFBFVVOR NGK2T5RKSzVyPUGwJO69VQ>? NFnl[HAzOzh2NECzPC=>
A431 NH;DRnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[zSFExKM7:TR?= M{LGW|czKGh? NXzPbJNOTE2VTx?= M2XYW2lEPTB;MUCg{txO NIfkfVIzOzh2NECzPC=>
A2780 M4L2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVn4dVdQOTBizszN M1flcVczKGh? NULV[lBiTE2VTx?= NVPPPJVIUUN3ME2xNEDPxE1? MmDkNlM5PDRyM{i=
ARH-77 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYexNEDPxE1? NV3pRoltPzJiaB?= M2\aSGROW09? MVfJR|UxRTFyIN88US=> MYOyN|g1PDB|OB?=
Be(2)C M1PjRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfjWoYyOCEQvF2= NYLvRWNyPzJiaB?= M3njZWROW09? NYf5V29FUUN3ME2xNEDPxE1? MViyN|g1PDB|OB?=
BT-20 NWHTPWt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHZN3BXOTBizszN MVG3NkBp Mn\SSG1UVw>? NWf2TGh4UUN3ME2xNEDPxE1? M{jKSlI{QDR2MEO4
BxPc3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYqxNEDPxE1? NX;jO5M6PzJiaB?= NFTF[VFFVVOR NG\We|NKSzVyPUGwJO69VQ>? NFv2O3kzOzh2NECzPC=>
C-4 I NVv4RnltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LPcVExKM7:TR?= MVO3NkBp MnLaSG1UVw>? MX7JR|UxRTFyIN88US=> M3Lrb|I{QDR2MEO4
C33A M3f2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[4NVAh|ryP NInWNXQ4OiCq M4Py[GROW09? MXjJR|UxRTFyIN88US=> M2DwS|I{QDR2MEO4
CAL-27 M1jYUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PMfVExKM7:TR?= M3nIclczKGh? M{n5cWROW09? NYq2PYdkUUN3ME2xNEDPxE1? M1nE[lI{QDR2MEO4
CAL-62 M3P4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P5W|ExKM7:TR?= M2i4ZVczKGh? MnLISG1UVw>? MVHJR|UxRTFyIN88US=> NEjRZXczOzh2NECzPC=>
Calu-3 NXPYPJAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HobFExKM7:TR?= MoLPO|IhcA>? MojlSG1UVw>? MY\JR|UxRTFyIN88US=> NYfFSGZZOjN6NESwN|g>
CaOV3 NETRZ5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnLNVAh|ryP NFLiNpc4OiCq NI\v[YJFVVOR NIf2ZotKSzVyPUGwJO69VQ>? MYGyN|g1PDB|OB?=
CGTHW1 NHr2e|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV:xNEDPxE1? NUfZVos5PzJiaB?= MWDEUXNQ MY\JR|UxRTFyIN88US=> NXSyPFNKOjN6NESwN|g>
CHL-1 NYSxeYg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj5NpZXOTBizszN MkfVO|IhcA>? MWnEUXNQ NWq4XHNwUUN3ME2xNEDPxE1? NETIXFczOzh2NECzPC=>
Colo320DM M4fSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWqxNEDPxE1? NV\CT4puPzJiaB?= M4G4TGROW09? MW\JR|UxRTFyIN88US=> NIL2VpAzOzh2NECzPC=>
Colo704 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6xNEDPxE1? M1PtZ|czKGh? NHjhbI1FVVOR M1TVVmlEPTB;MUCg{txO M3zYXFI{QDR2MEO4
COR-L23 NUe5e49ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TYcVExKM7:TR?= NEX3flg4OiCq MVrEUXNQ MUTJR|UxRTFyIN88US=> NFPrcpIzOzh2NECzPC=>
CRO-AP2 Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrJNVAh|ryP MV63NkBp M4\oeWROW09? NYrKN5lXUUN3ME2xNEDPxE1? NYHJdZhuOjN6NESwN|g>
Daudi Mkj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;oNVAh|ryP M3\xTFczKGh? M{nTNWROW09? MYjJR|UxRTFyIN88US=> NUCzW|VyOjN6NESwN|g>
DOTC 24510 NVjiPJJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3hW3R7OTBizszN NIjNNHA4OiCq M{TYPWROW09? NV;Vd2ZYUUN3ME2xNEDPxE1? M2LoVVI{QDR2MEO4
DU-145 NHnTcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOwNVAh|ryP NYD6OIV7PzJiaB?= NYLpZpNMTE2VTx?= M1rJdmlEPTB;MUCg{txO NFrIemgzOzh2NECzPC=>
EB-3 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nNUlExKM7:TR?= NWDRS2NSPzJiaB?= MmfJSG1UVw>? MYjJR|UxRTFyIN88US=> NIHIUmMzOzh2NECzPC=>
EFM-19 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXqNVAh|ryP MYq3NkBp NXK5PIlkTE2VTx?= MoH2TWM2OD1zMDFOwG0> M{n5R|I{QDR2MEO4
EKVX NVnSfY9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3aNVAh|ryP NEPQNYk4OiCq NV;1eFdlTE2VTx?= MkXxTWM2OD1zMDFOwG0> NXvoVG1XOjN6NESwN|g>
FaDu NWC3RoRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NESxOJQyOCEQvF2= NGDodVY4OiCq MWHEUXNQ NYjoZlR{UUN3ME2xNEDPxE1? MUSyN|g1PDB|OB?=
G401 NH\RSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv5NVAh|ryP Mm\HO|IhcA>? MofoSG1UVw>? MmTzTWM2OD1zMDFOwG0> NVrCVXYyOjN6NESwN|g>
HCC-70 M1jBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M161W|ExKM7:TR?= NU\GNmZJPzJiaB?= NGrpPXhFVVOR MVrJR|UxRTFyIN88US=> MYiyN|g1PDB|OB?=
HCC-1954 MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHr5fmIyOCEQvF2= NFfoZmk4OiCq MnvtSG1UVw>? M{XVcWlEPTB;MUCg{txO NYjndHhjOjN6NESwN|g>
Hela NWLEW2t{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3SNVAh|ryP MnrwO|IhcA>? NUjwcHNXTE2VTx?= NELmXJdKSzVyPUGwJO69VQ>? NV3SO|dyOjN6NESwN|g>
Hep3B Mn\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYCxNEDPxE1? M3O3UlczKGh? MlzoSG1UVw>? M{Pqd2lEPTB;MUCg{txO MnXvNlM5PDRyM{i=
HMCB NH74UG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYGxNEDPxE1? NEPPW3M4OiCq M3;jTWROW09? NWP3d2hJUUN3ME2xNEDPxE1? NUf5SZhWOjN6NESwN|g>
HN5 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW0NVAh|ryP M1XidFczKGh? NWmzWGpjTE2VTx?= MkP3TWM2OD1zMDFOwG0> MlyzNlM5PDRyM{i=
HOS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j2ZlExKM7:TR?= NYXF[mhGPzJiaB?= M2\YemROW09? MmP0TWM2OD1zMDFOwG0> M4CyPFI{QDR2MEO4
HPAF-II M1q4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnqdJQ3OTBizszN NUHjUoxbPzJiaB?= MW\EUXNQ NHfnOW5KSzVyPUGwJO69VQ>? NGjS[pkzOzh2NECzPC=>
Hs746.T M3PxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlG1NVAh|ryP NVXjOm5tPzJiaB?= MUTEUXNQ NXzHZmZMUUN3ME2xNEDPxE1? MU[yN|g1PDB|OB?=
HT Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYThc3Y6OTBizszN NWfsWmZSPzJiaB?= NVy0XIx{TE2VTx?= NWTzS3d6UUN3ME2xNEDPxE1? MYmyN|g1PDB|OB?=
HT-3 M1LLc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTJR49oOTBizszN MkDkO|IhcA>? NITwVHRFVVOR MoK2TWM2OD1zMDFOwG0> MnXjNlM5PDRyM{i=
HuNS-1 M4jS[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LRVVExKM7:TR?= NWX3coN6PzJiaB?= NILJS29FVVOR NIj0[4dKSzVyPUGwJO69VQ>? MYqyN|g1PDB|OB?=
IGROV1 NVjQ[4JVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:3Z2cyOCEQvF2= MYC3NkBp MYrEUXNQ NGTUcFdKSzVyPUGwJO69VQ>? NX\hd3l{OjN6NESwN|g>
J82 M2K5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;wXYkyOCEQvF2= M{PKe|czKGh? MXPEUXNQ NWLTZmxJUUN3ME2xNEDPxE1? NWLGe2x[OjN6NESwN|g>
JM1 Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDOXpJpOTBizszN M2D1dFczKGh? MXvEUXNQ NXvtclBmUUN3ME2xNEDPxE1? MVSyN|g1PDB|OB?=
Kato III NVTaR2tWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXyxNEDPxE1? NIKzeHo4OiCq NFXh[3FFVVOR NX;EZWF[UUN3ME2xNEDPxE1? NV74PJVFOjN6NESwN|g>
KHOS-240S MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYWxNEDPxE1? NYXDd|FVPzJiaB?= NWiyTWkzTE2VTx?= NWHCTVFYUUN3ME2xNEDPxE1? MlTGNlM5PDRyM{i=
KM-12 M{\jfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGftSZcyOCEQvF2= MYe3NkBp M1frbmROW09? NVPjOmZGUUN3ME2xNEDPxE1? Mmf3NlM5PDRyM{i=
KPL-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvwNVAh|ryP M4\JbFczKGh? Mm\jSG1UVw>? MmW1TWM2OD1zMDFOwG0> MljYNlM5PDRyM{i=
KYSE-30 M3j1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP1NVAh|ryP NHLpfpE4OiCq NU\YS4U2TE2VTx?= M4fuWmlEPTB;MUCg{txO Mk\PNlM5PDRyM{i=
LNCaP M3;NXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFraO|YyOCEQvF2= NGLIWXI4OiCq M3frSWROW09? NFLhZo5KSzVyPUGwJO69VQ>? MmfhNlM5PDRyM{i=
MCF-7 NUHEOFk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm3NVAh|ryP NIHkRY04OiCq NX3t[FNKTE2VTx?= NF;HbWNKSzVyPUGwJO69VQ>? NY\4UJBrOjN6NESwN|g>
MC-IXC M3;OUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnke3UyOCEQvF2= NFnl[G44OiCq MV;EUXNQ M2q3TmlEPTB;MUCg{txO MmLGNlM5PDRyM{i=
MDA-MB-175 VII Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[xNEDPxE1? NXP2NFNlPzJiaB?= Mo\USG1UVw>? MYjJR|UxRTFyIN88US=> MXGyN|g1PDB|OB?=
MDA-MB-468 M{n6PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfUdm86OTBizszN NIDxUGM4OiCq NYm5SJp[TE2VTx?= MonaTWM2OD1zMDFOwG0> M{PyflI{QDR2MEO4
MiaPaCa M3:zOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV64fZk2OTBizszN M4TPTlczKGh? MlvrSG1UVw>? NG[ycVFKSzVyPUGwJO69VQ>? NIXIUngzOzh2NECzPC=>
Molt-4 M3[ySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy4UmFQOTBizszN NV3iO3h5PzJiaB?= MYDEUXNQ MorHTWM2OD1zMDFOwG0> NVPsTHJEOjN6NESwN|g>
NCI-ADR/RES NISxSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XxUlExKM7:TR?= MnnyO|IhcA>? M4nuWGROW09? MWTJR|UxRTFyIN88US=> MUeyN|g1PDB|OB?=
NCI-H69 NGfjbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNEDPxE1? NYm5bZA5PzJiaB?= NIn6WWdFVVOR M370b2lEPTB;MUCg{txO NUXIZ4I{OjN6NESwN|g>
NCI-H82 NFLpNXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVyzOYJlOTBizszN NXHwUnZ{PzJiaB?= MlfMSG1UVw>? NW[5NXdbUUN3ME2xNEDPxE1? Mor5NlM5PDRyM{i=
NCI-N87 M4q4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVixNEDPxE1? MoTBO|IhcA>? NH:yW3dFVVOR NYfzeZZzUUN3ME2xNEDPxE1? MkPENlM5PDRyM{i=
NCI-H146 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfsZlg2OTBizszN NU\DOpVVPzJiaB?= NV7GdZRtTE2VTx?= M1\YRWlEPTB;MUCg{txO MnGxNlM5PDRyM{i=
NCI-H157 MnvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX6VlAyOCEQvF2= NVvs[JN6PzJiaB?= NHe5TFRFVVOR MXnJR|UxRTFyIN88US=> M4j0WlI{QDR2MEO4
NCI-H187 M4fnZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Lu[VExKM7:TR?= M165d|czKGh? MnrrSG1UVw>? NXfuZWxQUUN3ME2xNEDPxE1? NFjmRWUzOzh2NECzPC=>
NCI-H209 NIT0SXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rxbVExKM7:TR?= NV7FNXFZPzJiaB?= MoLESG1UVw>? MV;JR|UxRTFyIN88US=> MoLPNlM5PDRyM{i=
NCI-H226 NEDQUI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS4V|ByOTBizszN NV;veHppPzJiaB?= NVPUfVB7TE2VTx?= MUfJR|UxRTFyIN88US=> MVyyN|g1PDB|OB?=
NCI-H292 MkDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7FOmsyOCEQvF2= NELIdoU4OiCq MX3EUXNQ NVns[oFIUUN3ME2xNEDPxE1? MmTtNlM5PDRyM{i=
NCI-H322 NHXoRoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7vPXkyOCEQvF2= MWm3NkBp M4LsUmROW09? M17PNWlEPTB;MUCg{txO MlzYNlM5PDRyM{i=
NCI-H358 NVjMdHJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYGxNEDPxE1? NELUbpU4OiCq NWfPc2VyTE2VTx?= M37mSmlEPTB;MUCg{txO MoPpNlM5PDRyM{i=
NCI-H520 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLmdWEyOCEQvF2= MVu3NkBp M1fpeWROW09? MnzvTWM2OD1zMDFOwG0> MVWyN|g1PDB|OB?=
NCI-H526 NVzJZWl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:5NVAh|ryP NGq2RpE4OiCq NE\zOZVFVVOR NYrKdoczUUN3ME2xNEDPxE1? MljXNlM5PDRyM{i=
NCI-H630 MmraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDVNVAh|ryP NVHQOW9CPzJiaB?= MkL2SG1UVw>? NFr0fIJKSzVyPUGwJO69VQ>? MlvFNlM5PDRyM{i=
NCI-H661 NWLnT4VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmSzNVAh|ryP MoTwO|IhcA>? NVi3ZlN3TE2VTx?= NFLuRoZKSzVyPUGwJO69VQ>? NV;mXm94OjN6NESwN|g>
NCI-H716 NFXrTZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXuxOJJ6OTBizszN NXO3[IZ2PzJiaB?= NULQR2VRTE2VTx?= M4rCRWlEPTB;MUCg{txO NH;PNoczOzh2NECzPC=>
NCI-H1563 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3tNVAh|ryP NHr2bHg4OiCq MUHEUXNQ MlPITWM2OD1zMDFOwG0> NXexUnVsOjN6NESwN|g>
NCI-H1792 Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XOOVExKM7:TR?= M4jxRVczKGh? MoTkSG1UVw>? NVezNnRVUUN3ME2xNEDPxE1? Ml;4NlM5PDRyM{i=
NCI-H2030 NEjYVHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K5blExKM7:TR?= NFXtb2g4OiCq NUfzXnAxTE2VTx?= NE\XcmZKSzVyPUGwJO69VQ>? NVPQdmI4OjN6NESwN|g>
NCI-H2052 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q3bVExKM7:TR?= NE\SNYE4OiCq NFr1bIlFVVOR NV;mcFVWUUN3ME2xNEDPxE1? NFXMXoozOzh2NECzPC=>
NCI-H2122 NXS4WXpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn2VXIyOCEQvF2= NEDxNZU4OiCq M3LiPWROW09? M{XWNGlEPTB;MUCg{txO M2XVbVI{QDR2MEO4
NCI-H2228 NH;xTWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXX[|FNOTBizszN M4DJ[VczKGh? MYXEUXNQ M3;zRWlEPTB;MUCg{txO NV\6cVdDOjN6NESwN|g>
OE-19 MmPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TrOFExKM7:TR?= MUC3NkBp NU[3TmF6TE2VTx?= M4rGV2lEPTB;MUCg{txO MWiyN|g1PDB|OB?=
OE-21 NVi3W3dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUKxNEDPxE1? MnPsO|IhcA>? NF\ydIpFVVOR NIezSYtKSzVyPUGwJO69VQ>? NWfE[IJ4OjN6NESwN|g>
OE-33 NGDubGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[1XYZMOTBizszN NEfV[FQ4OiCq MVjEUXNQ MVrJR|UxRTFyIN88US=> NIfEeFUzOzh2NECzPC=>
OVCAR-3 M3O0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVixNEDPxE1? NIWx[3U4OiCq MWDEUXNQ MWrJR|UxRTFyIN88US=> MV2yN|g1PDB|OB?=
OVCAR-4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL6Wo96OTBizszN MWS3NkBp MnzOSG1UVw>? M2i1OWlEPTB;MUCg{txO NXTMPGJROjN6NESwN|g>
OVCAR-5 NVnmVZVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[wNVAh|ryP NYfJR3JHPzJiaB?= NGC0RWJFVVOR NXTYd3pTUUN3ME2xNEDPxE1? NYHocoJCOjN6NESwN|g>
P3HR-1 NX7MUI9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\pcFExKM7:TR?= MlzpO|IhcA>? M1OydGROW09? NIPFOnBKSzVyPUGwJO69VQ>? M2e4NlI{QDR2MEO4
PC-3 NUDtcm05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVqyNJY{OTBizszN M2HoOVczKGh? Mn7uSG1UVw>? MW\JR|UxRTFyIN88US=> NX3FW4t2OjN6NESwN|g>
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RD M334eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TveFExKM7:TR?= NEixPFg4OiCq MojhSG1UVw>? M3Xy[2lEPTB;MUCg{txO NXPxTo12OjN6NESwN|g>
RD-ES MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rOUFExKM7:TR?= NHj1dGw4OiCq M4fjfmROW09? MlPvTWM2OD1zMDFOwG0> NXjWPY06OjN6NESwN|g>
RL MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe1cokyOCEQvF2= NHzmNXc4OiCq M3S5ZWROW09? M4jtSGlEPTB;MUCg{txO MYGyN|g1PDB|OB?=
SaOS2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv5NVAh|ryP NGXJXIw4OiCq MYPEUXNQ NHjnVGVKSzVyPUGwJO69VQ>? M1jMUlI{QDR2MEO4
SCC-9 M4PGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfnRYozOTBizszN Mo\JO|IhcA>? NUf3eZU5TE2VTx?= NIHRN3VKSzVyPUGwJO69VQ>? NFPqSnYzOzh2NECzPC=>
SCC-12 Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXixNEDPxE1? NV[5c4hVPzJiaB?= NVe0Wpg1TE2VTx?= NVXJV3pvUUN3ME2xNEDPxE1? NVTCT3NnOjN6NESwN|g>
SCC-13 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYexNEDPxE1? M17TcVczKGh? NFHES4FFVVOR M{DoNGlEPTB;MUCg{txO MUCyN|g1PDB|OB?=
SCC-15 NVXjV3liT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K0TVExKM7:TR?= NWHyO2RvPzJiaB?= MWnEUXNQ NVr0SmpHUUN3ME2xNEDPxE1? Mnv1NlM5PDRyM{i=
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SJRH30 Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjsNVAh|ryP MUK3NkBp MV7EUXNQ MknuTWM2OD1zMDFOwG0> NEDUXngzOzh2NECzPC=>
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SK-LMS-1 M3PPXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e4fFExKM7:TR?= NU\He5p{PzJiaB?= MYDEUXNQ MUfJR|UxRTFyIN88US=> NIn5TFgzOzh2NECzPC=>
SK-N-DZ NUO5eo1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NImyVIUyOCEQvF2= MUW3NkBp M3q1bmROW09? NX\uT4YxUUN3ME2xNEDPxE1? MYCyN|g1PDB|OB?=
SK-N-F1 NWe0b2ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnFZ5EyOCEQvF2= NFHkVXo4OiCq NHrlc25FVVOR NYqzWYhHUUN3ME2xNEDPxE1? MWiyN|g1PDB|OB?=
SKOV-3 NH;tSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrkPG0yOCEQvF2= MWC3NkBp MYfEUXNQ NFjCcodKSzVyPUGwJO69VQ>? NWnRNW9oOjN6NESwN|g>
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SN12C MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy2fZlPOTBizszN M1G2c|czKGh? M{LDeGROW09? NVHPbXM2UUN3ME2xNEDPxE1? M3TGW|I{QDR2MEO4
SNB-19 MlvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljDNVAh|ryP M17uUlczKGh? Mnv1SG1UVw>? MoHsTWM2OD1zMDFOwG0> MnK1NlM5PDRyM{i=
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SW579 NU\O[5F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHuU4sxOTBizszN MlLHO|IhcA>? Mo\VSG1UVw>? MYDJR|UxRTFyIN88US=> NXP5PWFwOjN6NESwN|g>
SW684 M3K2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPqNIMyOCEQvF2= MlK4O|IhcA>? MnrGSG1UVw>? NHzD[FBKSzVyPUGwJO69VQ>? NFzYRpozOzh2NECzPC=>
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SW900 M2LNe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojSNVAh|ryP MlH5O|IhcA>? M3j2fmROW09? NELDb2FKSzVyPUGwJO69VQ>? MWKyN|g1PDB|OB?=
SW1088 NWO5eIdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHRNVAh|ryP NYLqcpQ2PzJiaB?= M3TQXmROW09? MYXJR|UxRTFyIN88US=> NELVVpIzOzh2NECzPC=>
SW1463 Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3SyWFExKM7:TR?= M3HBdVczKGh? MmDwSG1UVw>? NGrTNpVKSzVyPUGwJO69VQ>? M3G4W|I{QDR2MEO4
SW1990 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fxR|ExKM7:TR?= MVy3NkBp MojYSG1UVw>? MoW4TWM2OD1zMDFOwG0> NVfjcXc4OjN6NESwN|g>
T47D NH63[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVuxNEDPxE1? MoLGO|IhcA>? NGnF[|JFVVOR M1j1Z2lEPTB;MUCg{txO Mn\zNlM5PDRyM{i=
TE381.T MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXSxNEDPxE1? NVizdnl{PzJiaB?= NV20dIVjTE2VTx?= MYLJR|UxRTFyIN88US=> NIPHOmIzOzh2NECzPC=>
TK-10 NW\DXmJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjGVmkyOCEQvF2= MWK3NkBp M3XDUWROW09? NI\UPHRKSzVyPUGwJO69VQ>? Mkf6NlM5PDRyM{i=
U2OS MkHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYCxNEDPxE1? MkPSO|IhcA>? MmS3SG1UVw>? M1jQ[2lEPTB;MUCg{txO NVPXcHY5OjN6NESwN|g>
U251 M1j1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjqT3hoOTBizszN NEXDdnQ4OiCq MlHNSG1UVw>? M{Pjd2lEPTB;MUCg{txO M4TDNVI{QDR2MEO4
UACC-812 M1LhT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWqxT2s6OTBizszN MYC3NkBp M1HCN2ROW09? NVHsOYdzUUN3ME2xNEDPxE1? NX36V|V6OjN6NESwN|g>
YAPC NXjKcmo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLTXZUyOCEQvF2= NEnsPGY4OiCq MV7EUXNQ MnLBTWM2OD1zMDFOwG0> NIOxblYzOzh2NECzPC=>
ZR-75-1 M2[5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH2RZIyOCEQvF2= Mlv6O|IhcA>? NVHadZhWTE2VTx?= Mmq0TWM2OD1zMDFOwG0> MnjlNlM5PDRyM{i=
A375 NHXaZ2tHfW6ldHnvckBie3OjeR?= NVPHRodUOS5{IN88US=> Ml7UOEBp NEDlXItFVVOR MXnJcohq[mm2aX;uJI9nKHCqb4PwbI9zgWyjdHnvckBw\iCPRVusJGVTUyxiYX7kJHM3WA>? NWrXWWpDOjJ|OEm0O|E>
YUSIT1 MWDGeY5kfGmxbjDhd5NigQ>? MYfEUXNQ NIn0PYRz\WS3Y3XkJJNmdnOrdHn2bZR6KHerdHigTWM2OCB-IECuOUDPxE1? M{fVdFIzOzh7NEex
MeWo NHu0fWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn7NSG1UVw>? MoXrTWM2OCB;IEm4O{BvVQ>? MljiNlYxOTh3MkS=
WiDr NXGzb3RPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV\GbWh2TE2VTx?= MX\JR|UxKD1iN{[gcm0> M1fyfVI3ODF6NUK0
Colo-205 M4P6Z2Z2dmO2aX;uJIF{e2G7 NIHHOnUyKM7:TR?= M2DwN|Qh\A>? M{HFR2ROW09? MknHTY5lfWOnZDDhJIhq\2iueTDjc41x[XKjYnzlJINwdXCjY4Tpc44heGinbn;0fZBm MV2yOVM5OTF3Mh?=
RBW-1 MVXGeY5kfGmxbjDhd5NigQ>? MnjYNUDPxE1? M{XVeWROW09? Mo\NUo8hemWmdXP0bY9vKG:oIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v MWCyOFg5PTZ7MB?=
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M257 NGLUZm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjnUIUyODBibl2= M33NeVczKGh? NVu3NG86TG:nczDuc5QhcW6qaXLpeEBxem:uaX\ldoF1cW:wIH;mJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG M4HBXlI{OzF5NES2
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M257 M2fW[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUGxNFAhdk1? NXi4Zm9pPzJiaB?= M4rRUmRw\XNibn;0JIlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= MnzzNlM{OTd2NE[=
LCP MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED1d2IyODBibl2= MlrLO|IhcA>? MmizTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? MnjZNlM{OTd2NE[=
WM266 MmSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVyxNFAhdk1? MXe3NkBp NW\JOnh{UW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJHdOOjZ4IHPlcIwhcGG{Yn;1dolv\yCEUlHGJHY3ODCGIH31eIFvfGG2aX;u NVPib|ZJOjN|MUe0OFY>

... Click to View More Cell Line Experimental Data

In vivo試験 Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]
臨床試験 Dabrafenib is currently in phase 3 clinical trial in patients with melanoma.
特集

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Dabrafenib (GSK2118436) SDF
分子量 519.56
化学式

C23H20F3N5O2S2

CAS No. 1195765-45-7
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

文献中の引用 (12)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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