Dabrafenib (GSK2118436)

Dabrafenib(GSK2118436)は、B-Rafの強力なATP競争的阻害剤で、 B-Raf、 B-RafV600E 、c-Rafに作用する時、 IC50 がそれぞれ 3.2 nM、 0.8 nM 、 5.0 nMです。

価格 在庫  
USD 113 あり
USD 163 あり
USD 214 あり
USD 226 あり
USD 340 あり
USD 504 あり
電話番号: + 81 3-5632-9610mail@cosmobio.co.jp

Dabrafenib (GSK2118436) 化学構造
分子量: 519.56

高品質保証

カスタマーフィードバック(4)

MSDS

製品説明

  • Compare Raf Inhibitors
    Raf製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Dabrafenib(GSK2118436)は、B-Rafの強力なATP競争的阻害剤で、 B-Raf、 B-RafV600E 、c-Rafに作用する時、 IC50 がそれぞれ 3.2 nM、 0.8 nM 、 5.0 nMです。
ターゲット B-raf B-RafV600E c-Raf
IC50 3.2 nM 0.8 nM 5.0 nM [1]
In vitro試験 Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
MY\LbY5ie2ViQYPzZZk> MkDsTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFjpd{B1[WepZXSgRk1T[WZiVk[wNGUhdXW2YX70JIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMh[29vZYjwdoV{e2mwZzDDSGM{PyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBjcW:2aX75cIF1\WRvTVXLJJBzd3SnaX6gdIhwe3Cqb4L5cIF1cW:wIHL5JGFteGijU3Py[YVvKGG|c3H5JJdqfGhiSVO1NEBw\iByLkCwNFch|ryP Mn;oNlQ6ODB4N{O=
SK-MEL-28 NGGxUmhMcW6jc3WgRZN{[Xl? MkLYNUBp NEOwOnBKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xODRizszN MWOyOFkxODZ5Mx?=
HepG2 NGK1cFVMcW6jc3WgRZN{[Xl? NITUbXFKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDFVmsheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCwOEDPxE1? MXuyOFkxODZ5Mx?=
COLO205 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ThTGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OT{KwOUBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIECuNFA4KM7:TR?= MWeyOFkxODZ5Mx?=
HepG2 M1P4Z2Z2dmO2aX;uJGF{e2G7 NUHYXpV5PDVibXnu MX3EUXNQ M{XnNGlvcGmkaYTpc44hd2ZiQXzrOUBqdiCWR1[tZoV1[S2|dHnteYxifGWmIHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFOvYXSyJJBpd3OyaH;yfYxifGmxbjD0doVifGWmIH\vdkA1PSCvaX7zJJBzcW:{IITvJHRITi2kZYThJJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFYxKG2rboOgZpkhd2S7c4PlfUBjdG:2IIPjZY5v\XJiYX7hcJl{cXNid3n0bEBKSzVyIH;mJFMvPyEQvF2= MUWyOFkxODZ5Mx?=
HFF MnHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DrblExKM7:TR?= MVG3NkBp M1zadWROW09? NX\FfI57UW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIHj1cYFvKEiIRjDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIFKtVoFnKHerdHigTWM2OCCxZjCzJO69VQ>? NYTQN|FFOjN6NESwN|g>
SK-MEL-28 NHexUW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGftVm0yOCEQvF2= NV[1N5hHPzJiaB?= M1jMNWROW09? MVvJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfC2mcnn2[Y4hW0tvTVXMMVI5KGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xPDNizszN MWOyN|g1PDB|OB?=
A375P-F11 MlfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUWxNEDPxE1? MnPwO|IhcA>? MmnwSG1UVw>? MXfJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfC2mcnn2[Y4hSTN5NWCtSlEyKGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xPzFizszN NX\hW2xbOjN6NESwN|g>
MALME-3M MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\KVFExKM7:TR?= MUK3NkBp MlzaSG1UVw>? NXPjSoR3UUN3ME2xJI5O NGX4OIgzOzh2NECzPC=>
UACC-62 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHPRWcyOCEQvF2= NUK0[Xp7PzJiaB?= MYLEUXNQ MXXJR|UxRTFibl2= MoDuNlM5PDRyM{i=
C32TG NFT1R5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH24SpMyOCEQvF2= MknwO|IhcA>? MWPEUXNQ NWi5Z2dWUUN3ME2xJI5O NVfMUpNUOjN6NESwN|g>
SK-MEL-1 NGLFc2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7ZPZQyOCEQvF2= MWm3NkBp MoDESG1UVw>? MUjJR|UxRTJibl2= M3PxXFI{QDR2MEO4
M14 MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWxNEDPxE1? NH:3VJM4OiCq MXrEUXNQ MVLJR|UxRTJibl2= NYXRflJSOjN6NESwN|g>
SK-MEL-28 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXSxNEDPxE1? MXe3NkBp NEjOU2pFVVOR M{GydmlEPTB;MzDuUS=> NXLzc5VmOjN6NESwN|g>
A375 NEG0NJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrJNVAh|ryP NHHOcJc4OiCq NFHpNmxFVVOR MWPJR|UxRTRibl2= MVmyN|g1PDB|OB?=
DU-4475 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq4NVAh|ryP NFPEOoM4OiCq MUXEUXNQ MorBTWM2OD13IH7N M13iflI{QDR2MEO4
UACC-257 MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jP[lExKM7:TR?= NFrl[IE4OiCq Mn\mSG1UVw>? MWnJR|UxRTZibl2= NWjqeZNoOjN6NESwN|g>
Colo 205 MnPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PHPVExKM7:TR?= NX\TU3RFPzJiaB?= MUfEUXNQ MYLJR|UxRTdibl2= M3jNUlI{QDR2MEO4
SK-MEL-3 NVPKSFBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfydJAyOCEQvF2= MVS3NkBp MlWwSG1UVw>? NVPVTo5IUUN3ME23JI5O Mn;TNlM5PDRyM{i=
SH-4 MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVexNEDPxE1? NFHxSWc4OiCq NI\X[2ZFVVOR M37qc2lEPTB;ODDuUS=> NIHIT4MzOzh2NECzPC=>
A101D MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jTOFExKM7:TR?= MV23NkBp NEPYZ|ZFVVOR NWK4TGtnUUN3ME25JI5O MXeyN|g1PDB|OB?=
ES-2 NX2wTlh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Trb|ExKM7:TR?= Mkn3O|IhcA>? M4S3U2ROW09? M3y3c2lEPTB;NUOgcm0> NHHZPJEzOzh2NECzPC=>
HT-29 M1\RUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7GNVAh|ryP NETncXk4OiCq NIPyT2VFVVOR NGrTOWJKSzVyPU[2JI5O M3naOFI{QDR2MEO4
SW1417 M3vJ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPSNJcyOCEQvF2= M2H0SFczKGh? MnTJSG1UVw>? NXXwTVd1UUN3ME2xOVghdk1? MYqyN|g1PDB|OB?=
SW872 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVGxNEDPxE1? MWq3NkBp MWLEUXNQ NYPvXXJ6UUN3ME2zO|chdk1? M1y4UVI{QDR2MEO4
RKO M1PvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWixNEDPxE1? M1zYRVczKGh? MXfEUXNQ NFvSfVBKSzVyPUKuOVIzKM7:TR?= NH3MO|MzOzh2NECzPC=>
A673 NGD6[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjrfXVDOTBizszN M4rNcFczKGh? M3TiNmROW09? NWDDeWxMUUN3ME2xNEDPxE1? MW[yN|g1PDB|OB?=
GCT NUXJbGNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHSdWoyOCEQvF2= M2nhbFczKGh? NHziXJVFVVOR MX3JR|UxRTFyIN88US=> NEK5[3YzOzh2NECzPC=>
WM-115 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4O0e|ExKM7:TR?= NGPkVWs4OiCq MkXESG1UVw>? MnfSTWM2OD13IH7N M1vwUFI{QDR2MEO4
YUMAC NXLsNpNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLPNVAh|ryP MV:3NkBp NGry[JJFVVOR MmiwTWM2OD13IH7N MmfvNlM5PDRyM{i=
OV-90 NWnpdFZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT4UGNDOTBizszN MVe3NkBp NHOwd3VFVVOR MmThTWM2OD1{OTDuUS=> MoTHNlM5PDRyM{i=
NCI-H508 M3ntVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrMXWllOTBizszN MXq3NkBp M4H0PGROW09? Mnv5TWM2OD1zMDFOwG0> MX:yN|g1PDB|OB?=
MDA-MB-231 M3W1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Hsb|ExKM7:TR?= M3mzUFczKGh? NYKwV446TE2VTx?= NGDRW5JKSzVyPUGwJO69VQ>? NV6zZ4JIOjN6NESwN|g>
SW756 NGGxfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjoNVAh|ryP NUiySJp1PzJiaB?= MVPEUXNQ MWrJR|UxRTFyIN88US=> M4Lk[|I{QDR2MEO4
SW-837 NYLtZWdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjxWIxCOTBizszN NWX4OVBVPzJiaB?= MX7EUXNQ NES5Zo5KSzVyPUGwJO69VQ>? MlzHNlM5PDRyM{i=
UMUC-3 NFTST3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDtUoZCOTBizszN Mo\jO|IhcA>? MX3EUXNQ MXLJR|UxRTFyIN88US=> M{XaeFI{QDR2MEO4
LS-174T NYTXXZlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\tN5JDOTBizszN NFvRUFE4OiCq MmDKSG1UVw>? NGG1SWZKSzVyPUGwJO69VQ>? NYX1NZFYOjN6NESwN|g>
A549 NHPOSmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVixNEDPxE1? MWK3NkBp NFzIW2pFVVOR MUPJR|UxRTFyIN88US=> M1LVbFI{QDR2MEO4
SHP-77 M3vkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrsSWtNOTBizszN MorDO|IhcA>? MmHhSG1UVw>? NIHCfIpKSzVyPUGwJO69VQ>? Mn3DNlM5PDRyM{i=
SW480 M1;6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITYUmMyOCEQvF2= MVq3NkBp NETiT|NFVVOR M3fKbWlEPTB;MUCg{txO M4nmXVI{QDR2MEO4
DLD-1 MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TZUlExKM7:TR?= M4TXXVczKGh? MmnMSG1UVw>? MnfvTWM2OD1zMDFOwG0> Ml[3NlM5PDRyM{i=
HCT-116 M4nGNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYWwTJBqOTBizszN M1P1NVczKGh? NVu4cotwTE2VTx?= MmDFTWM2OD1zMDFOwG0> M1jOZ|I{QDR2MEO4
NCI-H747 Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3KU3MyOCEQvF2= MUC3NkBp MV3EUXNQ MkjITWM2OD1zMDFOwG0> M2Dwb|I{QDR2MEO4
T-84 M4XQTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj6NVAh|ryP M2n5XVczKGh? M{\BU2ROW09? NVPZcXRKUUN3ME2xNEDPxE1? MYGyN|g1PDB|OB?=
NCI-H460 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv0PWUyOCEQvF2= NEjXcXc4OiCq NGjyRnRFVVOR NH\mc2ZKSzVyPUGwJO69VQ>? MY[yN|g1PDB|OB?=
Calu-6 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrSeXpXOTBizszN MnziO|IhcA>? NHH6W|VFVVOR NHfrVoJKSzVyPUGwJO69VQ>? NGfCbZUzOzh2NECzPC=>
HCC-2998 M{fWcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP1NVAh|ryP Mmr6O|IhcA>? Mn23SG1UVw>? M13sfmlEPTB;MUCg{txO M2fj[lI{QDR2MEO4
LS1034 M1LmbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fsTFExKM7:TR?= NYLyc3hqPzJiaB?= NFPuOVdFVVOR NYTaZ5NRUUN3ME2xNEDPxE1? NUDL[HhHOjN6NESwN|g>
CHP-212 NGTOR|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILyfnQyOCEQvF2= MV23NkBp MojWSG1UVw>? MVjJR|UxRTFyIN88US=> MY[yN|g1PDB|OB?=
SK-N-AS NH23WVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;Zc5AyOCEQvF2= MYC3NkBp Ml:1SG1UVw>? MXHJR|UxRTFyIN88US=> MV:yN|g1PDB|OB?=
BFTC-905 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;pNVAh|ryP NGrTSlU4OiCq M3v2NGROW09? NHLNS29KSzVyPUGwJO69VQ>? MVKyN|g1PDB|OB?=
HuT78 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK1cHlxOTBizszN MnGxO|IhcA>? M1rFdmROW09? MoHnTWM2OD13MjDuUS=> NVX6c|NWOjN6NESwN|g>
RPMI-8226 NYXUSGNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jiW|ExKM7:TR?= NV:zbnVRPzJiaB?= MWPEUXNQ MXTJR|UxRTJ4MzDuUS=> NYftSGd{OjN6NESwN|g>
BC-3 M4fNS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDRVopqOTBizszN NWTQWWVVPzJiaB?= NFzYeJdFVVOR MlfaTWM2OD1{N{egcm0> NF7HTHYzOzh2NECzPC=>
ACHN M32wSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTtNVAh|ryP MkK1O|IhcA>? NGXhNHZFVVOR M4Pyd2lEPTB;Mkm0JI5O MUSyN|g1PDB|OB?=
JRT3-T35 NIXiWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWSxNEDPxE1? NGj3ZnM4OiCq NWf2fFhuTE2VTx?= MkjyTWM2OD1{OUWgcm0> NUS2Z4kyOjN6NESwN|g>
SK-MES-1 NVTwUZZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPUTnpPOTBizszN M1T6dlczKGh? NV3xc2xuTE2VTx?= NVPT[ZlCUUN3ME2zNlkhdk1? MlLVNlM5PDRyM{i=
CESS M3Lib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXmxNEDPxE1? NX\zUJBLPzJiaB?= NWm5UmJlTE2VTx?= MYLJR|UxRTR7NzDuUS=> MXGyN|g1PDB|OB?=
H4 M2XYSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq2WFIyOCEQvF2= NInhRnA4OiCq NVzLUGk1TE2VTx?= MV3JR|UxRTZzOTDuUS=> NGHiV24zOzh2NECzPC=>
BC-1 MkfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf5UnpsOTBizszN NVjUZoZkPzJiaB?= NX\CdW5OTE2VTx?= MXTJR|UxRTdyNDDuUS=> MknzNlM5PDRyM{i=
DB M1vZe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnBO4R7OTBizszN NYSyXJRRPzJiaB?= NH3RfYpFVVOR M1fLfmlEPTB;OEezJI5O MXOyN|g1PDB|OB?=
RPMI-6666 M1n6XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? MoDWO|IhcA>? NEDaWmFFVVOR MoTqTWM2OD17Mkigcm0> MVuyN|g1PDB|OB?=
MC/CAR M{XyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTpNVAh|ryP M1\4O|czKGh? MUfEUXNQ NH\XTmhKSzVyPUGuNFAzKM7:TR?= NHWxc5kzOzh2NECzPC=>
SNU-1 NUK0bWNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrBfGUzOTBizszN NES0S404OiCq M1LLVWROW09? NWTleWVLUUN3ME2xMlUxOSEQvF2= NYjHTlRQOjN6NESwN|g>
CEM/C1 NGT1cYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV63WIxWOTBizszN MVm3NkBp NYe1THR4TE2VTx?= NFG0NZNKSzVyPUGuO|c{KM7:TR?= Mo[1NlM5PDRyM{i=
GDM-1 NXHpWIRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrB[XhXOTBizszN M2n4fVczKGh? MojqSG1UVw>? MX\JR|UxRTFwOUm3JO69VQ>? MoL4NlM5PDRyM{i=
HT-1080 M13QXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjYc|MyOCEQvF2= M{DHUVczKGh? M2PMc2ROW09? MX7JR|UxRTJwMEC0JO69VQ>? NVP3[5hlOjN6NESwN|g>
HL-60 NFnONmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjJXFF7OTBizszN MojyO|IhcA>? MnTxSG1UVw>? MXTJR|UxRTJwMUe4JO69VQ>? NIDrRngzOzh2NECzPC=>
C3A MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPKNVAh|ryP M{HDU|czKGh? NIjxSHRFVVOR NEDjPIdKSzVyPUWuOFE1KM7:TR?= MXSyN|g1PDB|OB?=
MES-SA NWX5b2RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonCNVAh|ryP MmWzO|IhcA>? M4LiNWROW09? NHz2OYlKSzVyPU[uPVg6KM7:TR?= MorXNlM5PDRyM{i=
22Rv1 NHPPfXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHQNVAh|ryP NHvoe2w4OiCq NHLk[5RFVVOR Ml7STWM2OD1zMDFOwG0> NEfuV2kzOzh2NECzPC=>
647-V NIm0bYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzzW4syOCEQvF2= NH7tNoI4OiCq NWnB[FdbTE2VTx?= MYfJR|UxRTFyIN88US=> Mnq1NlM5PDRyM{i=
786-O MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S3d|ExKM7:TR?= NGnDSoQ4OiCq Ml33SG1UVw>? MVHJR|UxRTFyIN88US=> NF\xWW8zOzh2NECzPC=>
A172 M3\yfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVziUIZFOTBizszN NHnlUIw4OiCq MULEUXNQ MlXjTWM2OD1zMDFOwG0> NHriW4szOzh2NECzPC=>
A204 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi5TncyOCEQvF2= MlXhO|IhcA>? MVPEUXNQ NWXzfFBJUUN3ME2xNEDPxE1? NXHVWmtvOjN6NESwN|g>
A427 NXnVcmJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjWdW9VOTBizszN MWW3NkBp Ml3KSG1UVw>? Mm\DTWM2OD1zMDFOwG0> MUWyN|g1PDB|OB?=
A431 NXSweGxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIe0W5YyOCEQvF2= NEPZVIY4OiCq NVfmc4p{TE2VTx?= MWDJR|UxRTFyIN88US=> NGfn[nIzOzh2NECzPC=>
A2780 Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\ue|huOTBizszN NGrPd3c4OiCq M2fi[mROW09? M3HDXGlEPTB;MUCg{txO NULmfmUzOjN6NESwN|g>
ARH-77 MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVuxNEDPxE1? NEi0bGk4OiCq NYfS[2tiTE2VTx?= MkHHTWM2OD1zMDFOwG0> NYj2R|lFOjN6NESwN|g>
Be(2)C M2jLXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTkNVAh|ryP M{nNc|czKGh? M3ixSWROW09? MYjJR|UxRTFyIN88US=> MXyyN|g1PDB|OB?=
BT-20 NYDJR4JCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLmNVAh|ryP Ml3mO|IhcA>? NY[5ZnMzTE2VTx?= NFLpcGNKSzVyPUGwJO69VQ>? M4fEXVI{QDR2MEO4
BxPc3 NGLM[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTsOYYyOCEQvF2= NUDXN5FmPzJiaB?= MXfEUXNQ NV7HZYt7UUN3ME2xNEDPxE1? MY[yN|g1PDB|OB?=
C-4 I NYHEdodrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKxNEDPxE1? M1LVdVczKGh? M3vaPWROW09? NHLQT4FKSzVyPUGwJO69VQ>? M{PCO|I{QDR2MEO4
C33A MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rZSlExKM7:TR?= MlTkO|IhcA>? NYTCd2tsTE2VTx?= M2\5bWlEPTB;MUCg{txO NHLRSW4zOzh2NECzPC=>
CAL-27 MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNEDPxE1? NFTsVok4OiCq NXnEZVZFTE2VTx?= M{L6OmlEPTB;MUCg{txO M1;YSFI{QDR2MEO4
CAL-62 NFvt[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPNXFgyOCEQvF2= MWm3NkBp NXXNXWV{TE2VTx?= M3PwVGlEPTB;MUCg{txO NFzpN3UzOzh2NECzPC=>
Calu-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXTNVAh|ryP MYm3NkBp M2CxbWROW09? MoK5TWM2OD1zMDFOwG0> NIToZoEzOzh2NECzPC=>
CaOV3 Mn2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHnWWtyOTBizszN MWi3NkBp NIWxXIdFVVOR MXPJR|UxRTFyIN88US=> M3Ppc|I{QDR2MEO4
CGTHW1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmSwNVAh|ryP MmnLO|IhcA>? MVzEUXNQ NUewfFV5UUN3ME2xNEDPxE1? NIXZTZczOzh2NECzPC=>
CHL-1 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVuxNEDPxE1? M3:3d|czKGh? NX25c4FkTE2VTx?= M4TsSmlEPTB;MUCg{txO M3jhVVI{QDR2MEO4
Colo320DM Mon0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnu4NVAh|ryP NXW3enh[PzJiaB?= NF\xPVhFVVOR NIOySYJKSzVyPUGwJO69VQ>? Ml3tNlM5PDRyM{i=
Colo704 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6xNEDPxE1? MXq3NkBp M3T0WmROW09? MYjJR|UxRTFyIN88US=> M331XlI{QDR2MEO4
COR-L23 NHvzWZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX6NVAh|ryP NXHSUWJjPzJiaB?= MV3EUXNQ MkTVTWM2OD1zMDFOwG0> MWCyN|g1PDB|OB?=
CRO-AP2 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPLXJIyOCEQvF2= MVS3NkBp MUDEUXNQ M{T1SmlEPTB;MUCg{txO NXK3WXI2OjN6NESwN|g>
Daudi M{L6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjpNVAh|ryP Ml3IO|IhcA>? NFPYT3ZFVVOR NFOyNGpKSzVyPUGwJO69VQ>? M2LaRlI{QDR2MEO4
DOTC 24510 MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjPNVAh|ryP M1zsNlczKGh? M{XQSWROW09? MVjJR|UxRTFyIN88US=> NYrWOY13OjN6NESwN|g>
DU-145 MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\TS49iOTBizszN MYC3NkBp MXPEUXNQ NX;TTIs1UUN3ME2xNEDPxE1? MX6yN|g1PDB|OB?=
EB-3 NFLTN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWOxNEDPxE1? M1Hv[|czKGh? NW[2U4dXTE2VTx?= M{TJOGlEPTB;MUCg{txO M3y5RlI{QDR2MEO4
EFM-19 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLnNVAh|ryP MUi3NkBp M1:0UWROW09? MlPJTWM2OD1zMDFOwG0> NV31NFZnOjN6NESwN|g>
EKVX MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XSVlExKM7:TR?= NEO2XVk4OiCq MVvEUXNQ MULJR|UxRTFyIN88US=> NWrHcVRoOjN6NESwN|g>
FaDu NIXUbndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fWPVExKM7:TR?= NWTiWW1JPzJiaB?= NUj0Vlh[TE2VTx?= NFnVflZKSzVyPUGwJO69VQ>? MoDSNlM5PDRyM{i=
G401 MnnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f5TFExKM7:TR?= MX23NkBp M1uyfmROW09? M33BVmlEPTB;MUCg{txO MXKyN|g1PDB|OB?=
HCC-70 NH[5UZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXuxNEDPxE1? MX[3NkBp MoPlSG1UVw>? MYTJR|UxRTFyIN88US=> MmLqNlM5PDRyM{i=
HCC-1954 NIqybFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL6NVAh|ryP MorFO|IhcA>? Mnz2SG1UVw>? NFvSfVBKSzVyPUGwJO69VQ>? NYrHOmNmOjN6NESwN|g>
Hela M17ic2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\sWY8yOCEQvF2= MV[3NkBp NIm0[VhFVVOR MWXJR|UxRTFyIN88US=> NIPONm8zOzh2NECzPC=>
Hep3B MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz2RW06OTBizszN M2nXUFczKGh? NWnlXpJOTE2VTx?= MnTVTWM2OD1zMDFOwG0> NVG1TolGOjN6NESwN|g>
HMCB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorONVAh|ryP M{K1SlczKGh? NI\XZnJFVVOR MYjJR|UxRTFyIN88US=> M{LSVlI{QDR2MEO4
HN5 NYDRXnk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUGxNEDPxE1? MmLkO|IhcA>? M1TITGROW09? MXPJR|UxRTFyIN88US=> M4TVUFI{QDR2MEO4
HOS M1\Cfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHTVJQyOCEQvF2= MkDkO|IhcA>? NE\EOIZFVVOR MnXYTWM2OD1zMDFOwG0> NUDPRZJDOjN6NESwN|g>
HPAF-II M1fjUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fPbFExKM7:TR?= MWG3NkBp M1XKVmROW09? MYrJR|UxRTFyIN88US=> MlvWNlM5PDRyM{i=
Hs746.T MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjsTm13OTBizszN NHrWR5Q4OiCq M{LNNWROW09? NWPa[GpsUUN3ME2xNEDPxE1? NI\IboEzOzh2NECzPC=>
HT M{L5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nLVVExKM7:TR?= NG\ieI84OiCq M{nRVGROW09? MYPJR|UxRTFyIN88US=> MViyN|g1PDB|OB?=
HT-3 NXfRZ2R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXRcHJxOTBizszN NIG3bYI4OiCq NYjJcZQ4TE2VTx?= M33QVGlEPTB;MUCg{txO NYTURVNTOjN6NESwN|g>
HuNS-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e4TVExKM7:TR?= M1WxU|czKGh? MVjEUXNQ NXjlXIpNUUN3ME2xNEDPxE1? NXy3SZoxOjN6NESwN|g>
IGROV1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NECzXmkyOCEQvF2= NYqye5FmPzJiaB?= MWTEUXNQ MXfJR|UxRTFyIN88US=> MWSyN|g1PDB|OB?=
J82 M2rMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInmOmsyOCEQvF2= MkH1O|IhcA>? NIP0XXFFVVOR NXHiVmNsUUN3ME2xNEDPxE1? MoPiNlM5PDRyM{i=
JM1 NVL4NWtrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jKelExKM7:TR?= Ml7qO|IhcA>? MlzOSG1UVw>? M{\wVmlEPTB;MUCg{txO MXKyN|g1PDB|OB?=
Kato III NUHXVVdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj2coRTOTBizszN NXe2e|BIPzJiaB?= M3;FXWROW09? Mm\UTWM2OD1zMDFOwG0> NFnENY8zOzh2NECzPC=>
KHOS-240S NHTs[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\nV5NbOTBizszN NVfUbGVnPzJiaB?= MkLSSG1UVw>? NV[wN|NVUUN3ME2xNEDPxE1? MUKyN|g1PDB|OB?=
KM-12 M1rWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY[xNEDPxE1? MoHaO|IhcA>? NUnyPWtSTE2VTx?= NEfadFVKSzVyPUGwJO69VQ>? MUeyN|g1PDB|OB?=
KPL-1 NEXMNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[xNEDPxE1? MojPO|IhcA>? MYTEUXNQ MojxTWM2OD1zMDFOwG0> MYmyN|g1PDB|OB?=
KYSE-30 NUfqeYlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELtTWMyOCEQvF2= MUW3NkBp NVTKfnZmTE2VTx?= M33lVmlEPTB;MUCg{txO NYnFcXVsOjN6NESwN|g>
LNCaP NXL4coxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHjNVAh|ryP NVf3c4ZjPzJiaB?= Moq0SG1UVw>? Mn3iTWM2OD1zMDFOwG0> NUjobI5KOjN6NESwN|g>
MCF-7 NXPLdHhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV6xNEDPxE1? MXW3NkBp Mn7kSG1UVw>? MlvnTWM2OD1zMDFOwG0> NWjkXZZkOjN6NESwN|g>
MC-IXC M3zxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXKxNEDPxE1? NV;Hb4drPzJiaB?= M{exfGROW09? MYrJR|UxRTFyIN88US=> MUiyN|g1PDB|OB?=
MDA-MB-175 VII M3zXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUS5VFliOTBizszN M{XTNlczKGh? M4fHZ2ROW09? NIP5bWpKSzVyPUGwJO69VQ>? NGLQfpozOzh2NECzPC=>
MDA-MB-468 NV7MOplsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7XXnFJOTBizszN MmXtO|IhcA>? NF7rWJNFVVOR MYnJR|UxRTFyIN88US=> M{fBbVI{QDR2MEO4
MiaPaCa MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf5VmNoOTBizszN MnvEO|IhcA>? MkXKSG1UVw>? MUjJR|UxRTFyIN88US=> NYWyNVVxOjN6NESwN|g>
Molt-4 M1ftOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rJfFExKM7:TR?= NUfsR2ZjPzJiaB?= MkX2SG1UVw>? MXnJR|UxRTFyIN88US=> MnL0NlM5PDRyM{i=
NCI-ADR/RES MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fNOVExKM7:TR?= NVTjVJJHPzJiaB?= Mom5SG1UVw>? NWOzPYN4UUN3ME2xNEDPxE1? NHvEPZkzOzh2NECzPC=>
NCI-H69 NInYS4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4CydlExKM7:TR?= MnXTO|IhcA>? M4K2OWROW09? M{L5bmlEPTB;MUCg{txO MXeyN|g1PDB|OB?=
NCI-H82 NEDXToJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i1VlExKM7:TR?= MVW3NkBp NVrKZlBtTE2VTx?= NUjtOY9OUUN3ME2xNEDPxE1? M{X6TVI{QDR2MEO4
NCI-N87 NHjxSplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XrWlExKM7:TR?= NIfhTVc4OiCq M2DaSmROW09? NXLFT4hoUUN3ME2xNEDPxE1? M37ZSVI{QDR2MEO4
NCI-H146 M4fNbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnwXVkyOCEQvF2= NV\UTnI5PzJiaB?= MoriSG1UVw>? MlT5TWM2OD1zMDFOwG0> M3LSN|I{QDR2MEO4
NCI-H157 NGDweodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXexNEDPxE1? MmX3O|IhcA>? MVLEUXNQ NF\z[pFKSzVyPUGwJO69VQ>? MmWyNlM5PDRyM{i=
NCI-H187 NVvRb|dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGyTpF2OTBizszN NIPnfIM4OiCq NE[3fWNFVVOR M1uwS2lEPTB;MUCg{txO MWCyN|g1PDB|OB?=
NCI-H209 NITK[XVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrnSY1COTBizszN MV63NkBp M1z6e2ROW09? M3niVWlEPTB;MUCg{txO MYGyN|g1PDB|OB?=
NCI-H226 NILHfoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDNVm5ROTBizszN Mn3NO|IhcA>? MnW5SG1UVw>? MnK1TWM2OD1zMDFOwG0> M3y2UlI{QDR2MEO4
NCI-H292 NVLFbY1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnpdGQyOCEQvF2= NXnlc3dWPzJiaB?= NVzZVoFmTE2VTx?= NED5fFFKSzVyPUGwJO69VQ>? MWqyN|g1PDB|OB?=
NCI-H322 NVG2XFlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUOxNEDPxE1? MkDsO|IhcA>? MkSySG1UVw>? MVfJR|UxRTFyIN88US=> NWj5dVBFOjN6NESwN|g>
NCI-H358 NGS5TGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTLNVAh|ryP NFjZWVE4OiCq M1TFeWROW09? NVjHTFVkUUN3ME2xNEDPxE1? NVS3VmRHOjN6NESwN|g>
NCI-H520 M{m1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fEPFExKM7:TR?= NW\nPWxHPzJiaB?= NXzPNYJZTE2VTx?= NGXxV4FKSzVyPUGwJO69VQ>? MXqyN|g1PDB|OB?=
NCI-H526 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\rZZoyOCEQvF2= MVm3NkBp Mn7ZSG1UVw>? MnjCTWM2OD1zMDFOwG0> MnLTNlM5PDRyM{i=
NCI-H630 M2DWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlyyNVAh|ryP NH23OZQ4OiCq MVvEUXNQ NXLpTm01UUN3ME2xNEDPxE1? MmWwNlM5PDRyM{i=
NCI-H661 NXTme25DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmzNVAh|ryP NIXEbWg4OiCq NF;YOmJFVVOR M1PocGlEPTB;MUCg{txO NGr4WYszOzh2NECzPC=>
NCI-H716 NG\SOJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHzXnhJOTBizszN NFnGPIw4OiCq MYjEUXNQ Ml7yTWM2OD1zMDFOwG0> MXmyN|g1PDB|OB?=
NCI-H1563 M3[4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHMVGgyOCEQvF2= NUDwRlBEPzJiaB?= MnnCSG1UVw>? M4e1bmlEPTB;MUCg{txO NH3seVEzOzh2NECzPC=>
NCI-H1792 M3PaSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjoNVAh|ryP Mk\DO|IhcA>? NX3nd3dpTE2VTx?= M{[0c2lEPTB;MUCg{txO M2PhO|I{QDR2MEO4
NCI-H2030 NF\5dmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWCxNEDPxE1? M1j1PFczKGh? NWrVSYlPTE2VTx?= Mkm3TWM2OD1zMDFOwG0> M13oRVI{QDR2MEO4
NCI-H2052 Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\q[|ExKM7:TR?= MnvYO|IhcA>? NYHGfpVZTE2VTx?= NXnQephvUUN3ME2xNEDPxE1? M2rGZVI{QDR2MEO4
NCI-H2122 NFjlTmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUGxNEDPxE1? M3\NZlczKGh? MYTEUXNQ Mm\sTWM2OD1zMDFOwG0> MmXkNlM5PDRyM{i=
NCI-H2228 NYnQdWlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPsSokyOCEQvF2= NGXZO3Y4OiCq MmjZSG1UVw>? M4DlSWlEPTB;MUCg{txO NVzrNIhxOjN6NESwN|g>
OE-19 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvtbmoyOCEQvF2= Mn\6O|IhcA>? MVLEUXNQ MorsTWM2OD1zMDFOwG0> NUfnRVgzOjN6NESwN|g>
OE-21 NWXQb3JMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHCNG4yOCEQvF2= MkPVO|IhcA>? MWXEUXNQ MV7JR|UxRTFyIN88US=> NGXqV5IzOzh2NECzPC=>
OE-33 MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjafo1xOTBizszN M{LuOFczKGh? MmP4SG1UVw>? MmjxTWM2OD1zMDFOwG0> MUmyN|g1PDB|OB?=
OVCAR-3 NWTVdFhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDWNVAh|ryP M2n3VVczKGh? M4fsSGROW09? MnG5TWM2OD1zMDFOwG0> M4rsOFI{QDR2MEO4
OVCAR-4 M3jvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfVW5A6OTBizszN MYi3NkBp M1q1RWROW09? NFL3TWpKSzVyPUGwJO69VQ>? MnzzNlM5PDRyM{i=
OVCAR-5 NFXpOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL4TYgyOCEQvF2= M2W1TlczKGh? MWHEUXNQ MlLZTWM2OD1zMDFOwG0> NV3wfI5ROjN6NESwN|g>
P3HR-1 NWTnPI4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXzNXNDOTBizszN NYGw[IdzPzJiaB?= MoXWSG1UVw>? MYfJR|UxRTFyIN88US=> M3[xTVI{QDR2MEO4
PC-3 M3;HeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnrXlkyOCEQvF2= M1HRZVczKGh? MoXsSG1UVw>? NIftelJKSzVyPUGwJO69VQ>? NHPnT4gzOzh2NECzPC=>
Raji M3vjT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLsNVAh|ryP MV[3NkBp M4XjZmROW09? M3rBXGlEPTB;MUCg{txO NF7QU2szOzh2NECzPC=>
RD NIrue|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LyTVExKM7:TR?= MkDsO|IhcA>? NWDme|VSTE2VTx?= MV;JR|UxRTFyIN88US=> MUiyN|g1PDB|OB?=
RD-ES NXPGT3c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD2NpdNOTBizszN MoXFO|IhcA>? M4fWb2ROW09? MofkTWM2OD1zMDFOwG0> NXvL[oc{OjN6NESwN|g>
RL M4XJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrLNVAh|ryP MXy3NkBp NXvLUYdiTE2VTx?= NUnzT3V3UUN3ME2xNEDPxE1? NYPJdHNPOjN6NESwN|g>
SaOS2 MoGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLzTlAyOCEQvF2= NYfPWpJUPzJiaB?= NXnIOoR4TE2VTx?= MmG4TWM2OD1zMDFOwG0> Mo\lNlM5PDRyM{i=
SCC-9 M17OWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\6fHYyOCEQvF2= M1vzU|czKGh? MkDqSG1UVw>? NYDj[VBMUUN3ME2xNEDPxE1? MW[yN|g1PDB|OB?=
SCC-12 MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWCxNEDPxE1? NYXOWGJjPzJiaB?= NV3EXFhZTE2VTx?= NWrpNJRJUUN3ME2xNEDPxE1? NV;lVpp5OjN6NESwN|g>
SCC-13 NWr1VW1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUGxNEDPxE1? NH3UNJA4OiCq NFLjUXRFVVOR MYXJR|UxRTFyIN88US=> NG\ydoszOzh2NECzPC=>
SCC-15 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rweVExKM7:TR?= NF[xc4g4OiCq MV7EUXNQ MY\JR|UxRTFyIN88US=> MoXENlM5PDRyM{i=
SCC-25 MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfaNVAh|ryP MkH4O|IhcA>? Mnv2SG1UVw>? MleyTWM2OD1zMDFOwG0> NUPQTGcyOjN6NESwN|g>
SCLC-3 MkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HxTFExKM7:TR?= NHfRO3E4OiCq MWDEUXNQ MkXiTWM2OD1zMDFOwG0> MWeyN|g1PDB|OB?=
SF-268 M1u3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTxNVAh|ryP NVHKZ4tpPzJiaB?= NH[0b|ZFVVOR NIT1eVVKSzVyPUGwJO69VQ>? MUeyN|g1PDB|OB?=
SF-295 NYD6OXhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLkZodPOTBizszN NYXReVF3PzJiaB?= MWDEUXNQ M1;qRWlEPTB;MUCg{txO M3PRelI{QDR2MEO4
SJRH30 NYnNfldXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;6NVAh|ryP Ml;SO|IhcA>? NIDYU5BFVVOR MVfJR|UxRTFyIN88US=> M33OS|I{QDR2MEO4
SK-BR-3 NIPqOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfGOIUyOCEQvF2= NIjwUoU4OiCq NITN[oVFVVOR MoXhTWM2OD1zMDFOwG0> MV6yN|g1PDB|OB?=
SK-LMS-1 NH3MUnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfwOnAyOCEQvF2= M{PXfFczKGh? M4HYXGROW09? M{THXWlEPTB;MUCg{txO NVeyTGJ7OjN6NESwN|g>
SK-N-DZ MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTPNVAh|ryP M1rRS|czKGh? NUi4ZmlHTE2VTx?= NUnqbXExUUN3ME2xNEDPxE1? M{e5blI{QDR2MEO4
SK-N-F1 NU\wZmczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLxd|VuOTBizszN Mkj6O|IhcA>? NHPvTlFFVVOR MUTJR|UxRTFyIN88US=> NGK0SpMzOzh2NECzPC=>
SKOV-3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi3NVAh|ryP MoS2O|IhcA>? NUDkbVRLTE2VTx?= NEXDUndKSzVyPUGwJO69VQ>? MlPENlM5PDRyM{i=
SK-UT-1 Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH1NVAh|ryP NIO1NoM4OiCq M17HfmROW09? M1\EZ2lEPTB;MUCg{txO NWexWFNZOjN6NESwN|g>
SN12C MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPNR3VJOTBizszN MkLzO|IhcA>? M{\PRWROW09? NEL1[YhKSzVyPUGwJO69VQ>? MlnSNlM5PDRyM{i=
SNB-19 MofES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jJUlExKM7:TR?= NGTnbG44OiCq MVrEUXNQ MlLCTWM2OD1zMDFOwG0> MYiyN|g1PDB|OB?=
SNU-5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjEXWpWOTBizszN NG\3b|Y4OiCq NWrqbopiTE2VTx?= M4\RfGlEPTB;MUCg{txO MWCyN|g1PDB|OB?=
SNU-16 NUjyR5dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUmxNEDPxE1? MlzHO|IhcA>? M3jDZmROW09? NV\GRpJXUUN3ME2xNEDPxE1? M3zVZlI{QDR2MEO4
SNU-398 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjLUm93OTBizszN NFewPYo4OiCq MXHEUXNQ NXj1WXNsUUN3ME2xNEDPxE1? MV6yN|g1PDB|OB?=
SNU-449 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[5blgyOCEQvF2= NIXpO5M4OiCq MVXEUXNQ M2nuemlEPTB;MUCg{txO NHHtdFUzOzh2NECzPC=>
SR NXnVWYlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUmxNEDPxE1? NVOwT|RJPzJiaB?= MVzEUXNQ MXLJR|UxRTFyIN88US=> MXqyN|g1PDB|OB?=
ST486 MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG5NVAh|ryP MoLzO|IhcA>? NYGyemxTTE2VTx?= M3fpZWlEPTB;MUCg{txO M3m2clI{QDR2MEO4
SW579 NIT2XotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\nOlExKM7:TR?= NWe4d2dMPzJiaB?= Mo\DSG1UVw>? NUjjPIpjUUN3ME2xNEDPxE1? M1fGfFI{QDR2MEO4
SW684 MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XV[VExKM7:TR?= MV[3NkBp MnLxSG1UVw>? NYLSNIY{UUN3ME2xNEDPxE1? M4fOR|I{QDR2MEO4
SW-780 NF3uTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLUOHBCOTBizszN NFG5XYM4OiCq MWjEUXNQ MUjJR|UxRTFyIN88US=> NFXJNJozOzh2NECzPC=>
SW900 MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37PbFExKM7:TR?= MkC0O|IhcA>? NH\RRmlFVVOR NEXMR45KSzVyPUGwJO69VQ>? NXLyUmdMOjN6NESwN|g>
SW1088 NHHjOVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPBOXhvOTBizszN NVG4XmxUPzJiaB?= M{nuO2ROW09? NYW2SHJqUUN3ME2xNEDPxE1? MkDONlM5PDRyM{i=
SW1463 M{fJXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvDd41FOTBizszN MYq3NkBp MV3EUXNQ MlzGTWM2OD1zMDFOwG0> MX2yN|g1PDB|OB?=
SW1990 M2TKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHvNmUyOCEQvF2= M3HGWlczKGh? M3zzfWROW09? MV3JR|UxRTFyIN88US=> MlTHNlM5PDRyM{i=
T47D MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTvNVAh|ryP MWq3NkBp Mk[4SG1UVw>? MWjJR|UxRTFyIN88US=> NVnTd5E5OjN6NESwN|g>
TE381.T NHvUSHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHPdnQyOCEQvF2= NHGzRlY4OiCq MWnEUXNQ MX7JR|UxRTFyIN88US=> Mk\mNlM5PDRyM{i=
TK-10 NFPQNolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrldotvOTBizszN NXLRdGdCPzJiaB?= MUTEUXNQ NEL2RnJKSzVyPUGwJO69VQ>? NFnHfXkzOzh2NECzPC=>
U2OS M4HLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXubJhLOTBizszN M13Pd|czKGh? NEezfmpFVVOR NXraZ2JbUUN3ME2xNEDPxE1? NHvzXWozOzh2NECzPC=>
U251 NWWwN4doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLGOnYyOCEQvF2= MlTyO|IhcA>? MoXYSG1UVw>? NXPKb|dMUUN3ME2xNEDPxE1? NHnnfJMzOzh2NECzPC=>
UACC-812 NXnPXpVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjke4IyOCEQvF2= NI\6eI44OiCq NXjXbldmTE2VTx?= MoHjTWM2OD1zMDFOwG0> Mn7nNlM5PDRyM{i=
YAPC NV3KPGR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPZNVAh|ryP NV;Tc|V4PzJiaB?= NGjYflVFVVOR M{D5OGlEPTB;MUCg{txO M1HZRlI{QDR2MEO4
ZR-75-1 NVHIVIIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrJNVAh|ryP MkjiO|IhcA>? MljCSG1UVw>? MULJR|UxRTFyIN88US=> M4TsOFI{QDR2MEO4
A375 NXTld4tITnWwY4Tpc44h[XO|YYm= NXzPdmFJOS5{IN88US=> MVe0JIg> NV31NopwTE2VTx?= NFTnOmNKdmirYnn0bY9vKG:oIIDoc5NxcG:{eXzheIlwdiCxZjDNSWstKEWUSzygZY5lKFN4UB?= NXfESpdYOjJ|OEm0O|E>
YUSIT1 MnO3SpVv[3Srb36gZZN{[Xl? MY\EUXNQ MoS2doVlfWOnZDDz[Y5{cXSrdnn0fUB4cXSqIFnDOVAhRiByLkWg{txO MlyyNlI{QDl2N{G=
MeWo MnTpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NELUcZRFVVOR NV62ZZFnUUN3MDC9JFk5PyCwTR?= MlH2NlYxOTh3MkS=
WiDr MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIHWS3dFVVOR MUTJR|UxKD1iN{[gcm0> M3HocVI3ODF6NUK0
Colo-205 MXzGeY5kfGmxbjDhd5NigQ>? M2rxfVEh|ryP MkTOOEBl MoDZSG1UVw>? M{PxPWlv\HWlZXSgZUBpcWeqbImgZ49ueGG{YXLs[UBkd22yYXP0bY9vKHCqZX7veJlx\Q>? MYmyOVM5OTF3Mh?=
RBW-1 NIHvRpZHfW6ldHnvckBie3OjeR?= MnjRNUDPxE1? NUK4WY9mTE2VTx?= MoL6Uo8hemWmdXP0bY9vKG:oIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v MXWyOFg5PTZ7MB?=
RBO-1 M4H1ZWZ2dmO2aX;uJIF{e2G7 NGWzOVcyKM7:TR?= M4f5V2ROW09? NWL0ZnNvUW6qaXLpeIlwdiCxZjDN[YshOS9{IIDoc5NxcG:{eXzheIlwdg>? M3n1e|I1QDh3Nkmw
RBO-2 MlX1SpVv[3Srb36gZZN{[Xl? NFPhSoEyKM7:TR?= MYHEUXNQ M2nMNGlvcGmkaYTpc44hd2ZiIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v NEPOWpQzPDh6NU[5NC=>
RBOW MVjGeY5kfGmxbjDhd5NigQ>? NH[3emYyKM7:TR?= MXLEUXNQ Mkj3TY5pcWKrdHnvckBw\iBiTXXrJFEwOiCyaH;zdIhwenmuYYTpc44> Mny0NlQ5QDV4OUC=
M257 MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jMTlExOCCwTR?= MoOxO|IhcA>? MoXaSI9meyCwb4SgbY5pcWKrdDDwdo9tcW[ncnH0bY9vKG:oIF2yOVch[2WubDDoZZJjd3W{aX7nJJdqdGRidInw[UBDWkGI MUSyN|MyPzR2Nh?=
LCP MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[xNFAhdk1? NIjQe4Y4OiCq MVTJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhVEOSIHPlcIwhcGG{Yn;1dolv\yCEUlHGJHY3ODCUIH31eIFvfGG2aX;u MWWyN|MyPzR2Nh?=
WM266 NFHvZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXXZ2lEOTByIH7N MnzQO|IhcA>? MXLJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhX01{Nk[gZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMVSgcZV1[W62YYTpc44> MYqyN|MyPzR2Nh?=
M257 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXWUmgyODBibl2= MmTDO|IhcA>? MVzEc4V{KG6xdDDpcohq[mm2IFXST|EuOiCyaH;zdIhwenmuYYTpc44hcW5iTUK1O{Bk\WyuIHjhdoJwfXKrbnege4lt\CC2eYDlJGJTSUZ? Mk\RNlM{OTd2NE[=
LCP NYTETXlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS2TWkyODBibl2= NEHR[nA4OiCq MXnJcohq[mm2IFXST|EuOiCyaH;zdIhwenmuYYTpc44hcW5iTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v NWDNTJdzOjN|MUe0OFY>
WM266 NFn5eGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr0TokyODBibl2= MUi3NkBp M3HMZWlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDXUVI3PiClZXzsJIhiemKxdYLpcochSlKDRjDWOlAxTCCvdYThcpRifGmxbh?= M1PoSFI{OzF5NES2

... Click to View More Cell Line Experimental Data

In vivo試験 Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]
臨床試験 Dabrafenib is currently in phase 3 clinical trial in patients with melanoma.
特集

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Dabrafenib (GSK2118436) SDF
分子量 519.56
化学式

C23H20F3N5O2S2

CAS No. 1195765-45-7
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

文献中の引用 (12)

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related Raf 阻害剤

  • LY3009120

    LY03009120 is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.

  • GDC-0994

    GDC-0994 is a potent, orally available ERK1/2 inhibitor. Phase 1.

  • Ulixertinib (BVD-523, VRT752271)

    Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.

  • Cobimetinib (GDC-0973, RG7420)

    Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM. Phase 3.

  • Vemurafenib (PLX4032, RG7204)

    Vemurafenib (PLX4032, RG7204)新しくて強力な阻害剤で、 B-RAFV600Eに作用すると、IC50 が 31 nMになる。

    Features:A novel and potent inhibitor of the B-RAFV600E oncoprotein.

  • Sorafenib

    Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.

  • Sorafenib Tosylate

    Sorafenib Tosylateは一種の多種キナーゼ阻害剤です。Sorafenib Tosylateは無細胞試験でRaf-1、B-RafとVEGFR-2に作用する時のIC50値が6 nM、22 nMと90 nMにそれぞれ分かれます。

  • PLX-4720

    PLX-4720は、B-Raf(V600E)とc-Raf-1(Y340D/Y341D)の「実行中の」形の強力で選択的な阻害剤で、IC50 がそれぞれ 13 nM と 6.7 nMです。

  • TAK-632

    TAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(wt) and C-Raf, respectively, showing less or no inhibition against other tested kinases.

最近チェックしたアイテム

Tags: Dabrafenib (GSK2118436)を買う | Dabrafenib (GSK2118436)供給者 | Dabrafenib (GSK2118436)を購入する | Dabrafenib (GSK2118436)費用 | Dabrafenib (GSK2118436)生産者 | オーダーDabrafenib (GSK2118436) | Dabrafenib (GSK2118436)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ