Dabrafenib (GSK2118436)

Dabrafenib(GSK2118436)は、B-Rafの強力なATP競争的阻害剤で、 B-Raf、 B-RafV600E 、c-Rafに作用する時、 IC50 がそれぞれ 3.2 nM、 0.8 nM 、 5.0 nMです。

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Dabrafenib (GSK2118436) 化学構造
分子量: 519.56

高品質保証

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Quality Control & MSDS

製品説明

  • Compare Raf Inhibitors
    Raf製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Dabrafenib(GSK2118436)は、B-Rafの強力なATP競争的阻害剤で、 B-Raf、 B-RafV600E 、c-Rafに作用する時、 IC50 がそれぞれ 3.2 nM、 0.8 nM 、 5.0 nMです。
ターゲット B-raf B-RafV600E c-Raf
IC50 3.2 nM 0.8 nM 5.0 nM [1]
In vitro試験 Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
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SK-MEL-28 NXPvZml[U2mwYYPlJGF{e2G7 MlnWNUBp NGnWdZZKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xODRizszN NFLCeG8zPDlyME[3Ny=>
HepG2 MVLLbY5ie2ViQYPzZZk> M4fkZmlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC0JO69VQ>? M{exRlI1QTByNkez
COLO205 NELHTGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLJbIZGUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPNlA2KGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xODdizszN NVz2fVRNOjR7MEC2O|M>
HepG2 MmTpSpVv[3Srb36gRZN{[Xl? NIXpSVQ1PSCvaX6= NIPnTnhFVVOR MoG5TY5pcWKrdHnvckBw\iCDbHu1JIlvKFSJRj3i[ZRiNXO2aX31cIF1\WRiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hW22jZEKgdIhwe3Cqb4L5cIF1cW:wIITy[YF1\WRiZn;yJFQ2KG2rboOgdJJqd3JidH:gWGdHNWKndHGgd5RqdXWuYYTpc44hdWWjc4Xy[YQh[W[2ZYKgOlAhdWmwczDifUBw\Hm|c3X5JIJtd3Ric3Phco5meiCjbnHsfZNqeyC5aYToJGlEPTBib3[gN{44KM7:TR?= NWjrXmd{OjR7MEC2O|M>
HFF MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTObHIyOCEQvF2= MXK3NkBp NEC3bZlFVVOR MmHETY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKGi3bXHuJGhHTiClZXzsd{Bp[XKkb4Lpcochf2muZDD0fZBmKEJvUnHmJJdqfGhiSVO1NEBw\iB|IN88US=> MX[yN|g1PDB|OB?=
SK-MEL-28 NVXqeHdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSxNEDPxE1? MYe3NkBp MVfEUXNQ NXvYclNSUW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSt[JJqfmWwIGPLMW1GVC1{ODDj[YxtKHC{b3zp[oVz[XSrb36ge4l1cCCLQ{WwJI9nKDBwMESzJO69VQ>? MXyyN|g1PDB|OB?=
A375P-F11 NU\yZ2VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj2bIxnOTBizszN NYn4coVkPzJiaB?= M{P0PWROW09? Ml;KTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKEF|N{XQMWYyOSClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODdzIN88US=> NVLFOZBtOjN6NESwN|g>
MALME-3M M1PkWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWCxNEDPxE1? NYGyWnJJPzJiaB?= NF\1dGpFVVOR NXi1cGlEUUN3ME2xJI5O MkKxNlM5PDRyM{i=
UACC-62 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6xNEDPxE1? MV[3NkBp NUnUXnVTTE2VTx?= M{DGcWlEPTB;MTDuUS=> MWmyN|g1PDB|OB?=
C32TG M4Lvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D5[VExKM7:TR?= NFvadok4OiCq NGS2VHZFVVOR NX75T5F7UUN3ME2xJI5O Ml;jNlM5PDRyM{i=
SK-MEL-1 NYr1N2VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDnTWZbOTBizszN NVvtXpBqPzJiaB?= MWLEUXNQ NVjyPGR7UUN3ME2yJI5O Mlu0NlM5PDRyM{i=
M14 MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfFU4xWOTBizszN M2ToSFczKGh? M3PQTmROW09? NHfGelVKSzVyPUKgcm0> M2G5XVI{QDR2MEO4
SK-MEL-28 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTQeIZMOTBizszN NWSyZ45tPzJiaB?= MoHXSG1UVw>? NYTjVnh{UUN3ME2zJI5O MXOyN|g1PDB|OB?=
A375 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjnRo4yOCEQvF2= NE\rT|Q4OiCq NF70SoVFVVOR M4LJW2lEPTB;NDDuUS=> NX7ufJpKOjN6NESwN|g>
DU-4475 NELKeZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i1eVExKM7:TR?= MUi3NkBp MnfKSG1UVw>? NFnTTFdKSzVyPUWgcm0> MWmyN|g1PDB|OB?=
UACC-257 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn2wNVAh|ryP MWG3NkBp NFPGe2lFVVOR NYjPfZVSUUN3ME22JI5O Ml7jNlM5PDRyM{i=
Colo 205 MkLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPONVAh|ryP NUTMfW1LPzJiaB?= MXLEUXNQ NX32ZYJGUUN3ME23JI5O NELIb2czOzh2NECzPC=>
SK-MEL-3 MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWxNEDPxE1? M1LWWFczKGh? NV:0doZpTE2VTx?= NHXmUphKSzVyPUegcm0> MkW5NlM5PDRyM{i=
SH-4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYCxNEDPxE1? MoLPO|IhcA>? MYTEUXNQ M4PXUmlEPTB;ODDuUS=> NYPEO4RQOjN6NESwN|g>
A101D NGT4bndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\zV|ExKM7:TR?= NULaUJI1PzJiaB?= NHv1NlZFVVOR NHrLZZpKSzVyPUmgcm0> NH7md3kzOzh2NECzPC=>
ES-2 M1q5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVyxNEDPxE1? MmX1O|IhcA>? NYDHOJBMTE2VTx?= MWDJR|UxRTV|IH7N NV7FNpJlOjN6NESwN|g>
HT-29 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYGxNEDPxE1? MV:3NkBp M1jOO2ROW09? M1jRdWlEPTB;Nk[gcm0> NEPBZWMzOzh2NECzPC=>
SW1417 M{[xXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn1NVAh|ryP NH\xXpE4OiCq MX\EUXNQ NVXqWoplUUN3ME2xOVghdk1? NEfqOYkzOzh2NECzPC=>
SW872 NF7weVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:xNVAh|ryP NHiwVWU4OiCq NWLpe5NGTE2VTx?= MnzaTWM2OD1|N{egcm0> M4\yRlI{QDR2MEO4
RKO MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXqxNEDPxE1? M1v6SlczKGh? MoLHSG1UVw>? M4XMbmlEPTB;Mj61NlIh|ryP NHvvWlEzOzh2NECzPC=>
A673 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPaV2RDOTBizszN NFTmOIk4OiCq NFvuZZhFVVOR NXHMVWQ3UUN3ME2xNEDPxE1? NWHIbGFvOjN6NESwN|g>
GCT M37z[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHSNVAh|ryP MXW3NkBp NX:4emNRTE2VTx?= MVnJR|UxRTFyIN88US=> M{G3SlI{QDR2MEO4
WM-115 MkH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r2NFExKM7:TR?= NXrHU2hyPzJiaB?= NXz1dlR6TE2VTx?= NIHOc|RKSzVyPUWgcm0> MoS2NlM5PDRyM{i=
YUMAC NV7LeYpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVuxNEDPxE1? Mn\3O|IhcA>? MV;EUXNQ NHvoXo1KSzVyPUWgcm0> MX[yN|g1PDB|OB?=
OV-90 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fnUVExKM7:TR?= M4\sRVczKGh? NX:weYUyTE2VTx?= MYXJR|UxRTJ7IH7N M{L0VVI{QDR2MEO4
NCI-H508 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\5NVAh|ryP M37udVczKGh? Mn71SG1UVw>? M3XtNWlEPTB;MUCg{txO M3fIVlI{QDR2MEO4
MDA-MB-231 M1XNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL4NVAh|ryP MUK3NkBp MWTEUXNQ MXTJR|UxRTFyIN88US=> NXnvTIZwOjN6NESwN|g>
SW756 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYGxNEDPxE1? NGnFRpo4OiCq MWfEUXNQ NVjrfHRlUUN3ME2xNEDPxE1? MYKyN|g1PDB|OB?=
SW-837 NHfyTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzkXIcyOCEQvF2= NWnmdmI5PzJiaB?= NV\EXYZKTE2VTx?= NHvBd|BKSzVyPUGwJO69VQ>? NYj3XIhTOjN6NESwN|g>
UMUC-3 NXPCcIJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:xNEDPxE1? Mlz0O|IhcA>? NYHaSVJDTE2VTx?= NFnSZnJKSzVyPUGwJO69VQ>? NVrXRZN1OjN6NESwN|g>
LS-174T NYX2dmVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXmxNEDPxE1? M2TnZlczKGh? MmTSSG1UVw>? M33DV2lEPTB;MUCg{txO NYnVfHk6OjN6NESwN|g>
A549 NUK1S3h6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLmXnoyOCEQvF2= MknjO|IhcA>? MmPySG1UVw>? MXHJR|UxRTFyIN88US=> M2rH[lI{QDR2MEO4
SHP-77 MoPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLxSnYyOCEQvF2= NGraR3A4OiCq Ml3ISG1UVw>? NEHrZ4pKSzVyPUGwJO69VQ>? M1vRNlI{QDR2MEO4
SW480 MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLPdXV5OTBizszN MV63NkBp NVrZUnFqTE2VTx?= NES0WJRKSzVyPUGwJO69VQ>? NITFS2gzOzh2NECzPC=>
DLD-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy4T3ZtOTBizszN MUG3NkBp NX:xPXFuTE2VTx?= M1zveGlEPTB;MUCg{txO MmG2NlM5PDRyM{i=
HCT-116 NIi2SoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYexNEDPxE1? M2rndlczKGh? NWHyZ4l2TE2VTx?= MX3JR|UxRTFyIN88US=> M4e0WFI{QDR2MEO4
NCI-H747 M2ewVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XFcFExKM7:TR?= NXz2cYJJPzJiaB?= M4izeGROW09? NH3hbI1KSzVyPUGwJO69VQ>? NIfCN3AzOzh2NECzPC=>
T-84 NGXN[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjkRoRSOTBizszN M{PEbFczKGh? NUHJRVVqTE2VTx?= M2LsTmlEPTB;MUCg{txO M3LQOlI{QDR2MEO4
NCI-H460 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmxNEDPxE1? M2K0OVczKGh? NUXVVpNnTE2VTx?= MXHJR|UxRTFyIN88US=> NFLlUI4zOzh2NECzPC=>
Calu-6 NXvTclMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPPO5MyOCEQvF2= MoTRO|IhcA>? MmXFSG1UVw>? M4\VOGlEPTB;MUCg{txO M124[FI{QDR2MEO4
HCC-2998 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWqxNEDPxE1? M4DQ[lczKGh? Mn:3SG1UVw>? MUnJR|UxRTFyIN88US=> NUKwTGw2OjN6NESwN|g>
LS1034 M1\Gbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXexNEDPxE1? NEXUU4E4OiCq NGfHOItFVVOR MX7JR|UxRTFyIN88US=> MmfwNlM5PDRyM{i=
CHP-212 NXyxSXNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj3W5EyOTBizszN M2\5[FczKGh? MortSG1UVw>? Mnm4TWM2OD1zMDFOwG0> MV6yN|g1PDB|OB?=
SK-N-AS M4nYXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXWZWYyOCEQvF2= MmjIO|IhcA>? Mn;nSG1UVw>? MWTJR|UxRTFyIN88US=> NFywZpQzOzh2NECzPC=>
BFTC-905 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWGxNEDPxE1? MmL1O|IhcA>? MX;EUXNQ NH;SW|JKSzVyPUGwJO69VQ>? NXSxTmplOjN6NESwN|g>
HuT78 NX6yWXh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:xNEDPxE1? MWO3NkBp MoGySG1UVw>? MnTzTWM2OD13MjDuUS=> M3XtdFI{QDR2MEO4
RPMI-8226 NUjMRnBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXSxNEDPxE1? M4m1WFczKGh? M1vQbGROW09? M2XyNGlEPTB;Mk[zJI5O M1XI[lI{QDR2MEO4
BC-3 NX:y[412T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzzbpZ5OTBizszN MlnOO|IhcA>? MlXXSG1UVw>? M4Tl[mlEPTB;Mke3JI5O M4TjXlI{QDR2MEO4
ACHN M4T3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\INVAh|ryP Mk\GO|IhcA>? NYHnbZhkTE2VTx?= MnjJTWM2OD1{OUSgcm0> M2Ll[|I{QDR2MEO4
JRT3-T35 NGPTbldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7UPXIyOCEQvF2= M1jnSVczKGh? NELlbIFFVVOR M1T6cGlEPTB;Mkm1JI5O M2Ph[lI{QDR2MEO4
SK-MES-1 NWH2XXJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPFNVAh|ryP M1j2eVczKGh? MYHEUXNQ NFK2eFhKSzVyPUOyPUBvVQ>? NEfWfoszOzh2NECzPC=>
CESS NF\XVZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknuNVAh|ryP NHjrTIo4OiCq MWXEUXNQ M{jnNGlEPTB;NEm3JI5O M3nwXlI{QDR2MEO4
H4 NGfVO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Lob|ExKM7:TR?= MYe3NkBp MkTKSG1UVw>? MVPJR|UxRTZzOTDuUS=> NFPTOJgzOzh2NECzPC=>
BC-1 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrENVAh|ryP Mmf3O|IhcA>? MWPEUXNQ M{fqVGlEPTB;N{C0JI5O M3\D[FI{QDR2MEO4
DB NH30T29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVixNEDPxE1? NXXoWZFWPzJiaB?= M4fyXGROW09? MWTJR|UxRTh5MzDuUS=> M3;0eVI{QDR2MEO4
RPMI-6666 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUCxNEDPxE1? NGLDcYM4OiCq M4TVV2ROW09? MmTFTWM2OD17Mkigcm0> MkDGNlM5PDRyM{i=
MC/CAR NGTO[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G1e|ExKM7:TR?= MljzO|IhcA>? MkmwSG1UVw>? NWTqfVFsUUN3ME2xMlAxOiEQvF2= MXKyN|g1PDB|OB?=
SNU-1 NUPONGt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC1NVAh|ryP NUfjUVd3PzJiaB?= MX;EUXNQ M2LUZWlEPTB;MT61NFEh|ryP NGLS[4gzOzh2NECzPC=>
CEM/C1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTCTGVkOTBizszN NUnrNXVzPzJiaB?= NUTS[YVMTE2VTx?= MW\JR|UxRTFwN{ezJO69VQ>? NFn5ZVYzOzh2NECzPC=>
GDM-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFflWWMyOCEQvF2= Mor2O|IhcA>? NG\rSWVFVVOR MnrGTWM2OD1zLkm5O{DPxE1? M{n6PFI{QDR2MEO4
HT-1080 M1zJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPhRYh6OTBizszN MYm3NkBp NUnZdmtITE2VTx?= NHvZZllKSzVyPUKuNFA1KM7:TR?= MoezNlM5PDRyM{i=
HL-60 NH76VmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV35d4xGOTBizszN MkDyO|IhcA>? NX;hbVY{TE2VTx?= NID0c45KSzVyPUKuNVc5KM7:TR?= M3;zOlI{QDR2MEO4
C3A NILkT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUKxNEDPxE1? MkHSO|IhcA>? NUnxS|diTE2VTx?= M{j6bmlEPTB;NT60NVQh|ryP M2rTWFI{QDR2MEO4
MES-SA NV[z[m53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrHOJZ5OTBizszN M4rZOFczKGh? M33abGROW09? NWjqXJpNUUN3ME22Mlk5QSEQvF2= NHP2XHczOzh2NECzPC=>
22Rv1 MlvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\sU2UyOCEQvF2= M1zReVczKGh? M3vO[WROW09? NIftfHBKSzVyPUGwJO69VQ>? MXmyN|g1PDB|OB?=
647-V Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PkOlExKM7:TR?= NFu5ZlM4OiCq M2LGVWROW09? MV;JR|UxRTFyIN88US=> M{\kV|I{QDR2MEO4
786-O NUntXGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnhdWNyOTBizszN NHj0c5U4OiCq NFT4NppFVVOR M{D5d2lEPTB;MUCg{txO MoXWNlM5PDRyM{i=
A172 NYjINYZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGxNEDPxE1? MlrTO|IhcA>? M{PXW2ROW09? M3zpWGlEPTB;MUCg{txO MXOyN|g1PDB|OB?=
A204 MoP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzENFVpOTBizszN M1TLdlczKGh? MXPEUXNQ MV3JR|UxRTFyIN88US=> NGP4e3ozOzh2NECzPC=>
A427 MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\M[IJTOTBizszN NF3LcXc4OiCq M1\aTWROW09? M2XjR2lEPTB;MUCg{txO MXSyN|g1PDB|OB?=
A431 Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWOxNEDPxE1? NVTxPFhkPzJiaB?= NEPob|JFVVOR MXjJR|UxRTFyIN88US=> MljENlM5PDRyM{i=
A2780 NF65c4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrmW5c2OTBizszN M2HCflczKGh? MXTEUXNQ NYHZWlY3UUN3ME2xNEDPxE1? NIrJVYEzOzh2NECzPC=>
ARH-77 NXzDNZo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3y2[|ExKM7:TR?= M1TGbVczKGh? MV7EUXNQ M3zjeGlEPTB;MUCg{txO NWjJT5A4OjN6NESwN|g>
Be(2)C NVSxd5RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;qNVAh|ryP MV63NkBp MX3EUXNQ M2PwO2lEPTB;MUCg{txO MonONlM5PDRyM{i=
BT-20 NWL1cnBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq5VHVxOTBizszN MXO3NkBp NGXXOItFVVOR MlzhTWM2OD1zMDFOwG0> M2LVbVI{QDR2MEO4
BxPc3 MonXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDWNVAh|ryP M1mxVFczKGh? MUPEUXNQ NVnBNIFnUUN3ME2xNEDPxE1? MVuyN|g1PDB|OB?=
C-4 I M37TUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVKxNEDPxE1? NV7LZ3pOPzJiaB?= M3L5WmROW09? NEjON5JKSzVyPUGwJO69VQ>? MXGyN|g1PDB|OB?=
C33A NEK2NZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PWdlExKM7:TR?= NFXjO2w4OiCq NE[0fHlFVVOR MmmxTWM2OD1zMDFOwG0> Mn7aNlM5PDRyM{i=
CAL-27 NV24Xo52T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv0SJlNOTBizszN MWG3NkBp NHHHfpZFVVOR MYHJR|UxRTFyIN88US=> M4\mSVI{QDR2MEO4
CAL-62 M4HjN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml6wNVAh|ryP Mmf0O|IhcA>? NFfxPG5FVVOR NX\4VIg1UUN3ME2xNEDPxE1? NYXI[3dZOjN6NESwN|g>
Calu-3 NX7WOVZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnSZ2FoOTBizszN M1jOdVczKGh? MnL1SG1UVw>? MmjRTWM2OD1zMDFOwG0> NHjnSmQzOzh2NECzPC=>
CaOV3 Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXOzcYJZOTBizszN NWi2O3NRPzJiaB?= MontSG1UVw>? MWfJR|UxRTFyIN88US=> NGPLcmszOzh2NECzPC=>
CGTHW1 M3f1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHezdlUyOCEQvF2= NVTCSIQ4PzJiaB?= MUnEUXNQ M1LEPGlEPTB;MUCg{txO M3\6RlI{QDR2MEO4
CHL-1 NXPXcXd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrpNpgyOCEQvF2= NGD0U2I4OiCq M2D6cmROW09? MYjJR|UxRTFyIN88US=> MXeyN|g1PDB|OB?=
Colo320DM MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLxNJZ5OTBizszN MkLQO|IhcA>? NULyXWJGTE2VTx?= MUDJR|UxRTFyIN88US=> M4jlT|I{QDR2MEO4
Colo704 NYLuWng1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\3NVAh|ryP NV\RU4s6PzJiaB?= MW\EUXNQ MofDTWM2OD1zMDFOwG0> MlPWNlM5PDRyM{i=
COR-L23 M3zQTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDHNVAh|ryP NHGx[2g4OiCq M2DMR2ROW09? NYK2TYd6UUN3ME2xNEDPxE1? M4PzXFI{QDR2MEO4
CRO-AP2 Mn;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDBUZROOTBizszN MYm3NkBp MnvDSG1UVw>? NGXIOmJKSzVyPUGwJO69VQ>? MV[yN|g1PDB|OB?=
Daudi NFrBfmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNEDPxE1? NV3sPVVUPzJiaB?= NYLOdGNUTE2VTx?= NE\pSnZKSzVyPUGwJO69VQ>? NFrZeFMzOzh2NECzPC=>
DOTC 24510 NYH1VI9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV6y[|FSOTBizszN NX[xWYRXPzJiaB?= MXTEUXNQ NWTiRYFuUUN3ME2xNEDPxE1? MVqyN|g1PDB|OB?=
DU-145 MnWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv5[I4yOCEQvF2= NGTzcI84OiCq MoPwSG1UVw>? Mmj0TWM2OD1zMDFOwG0> NHnzSYkzOzh2NECzPC=>
EB-3 NXHUUGZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XQdFExKM7:TR?= MonnO|IhcA>? M2DP[WROW09? M3H1TGlEPTB;MUCg{txO Ml3HNlM5PDRyM{i=
EFM-19 NIfvOZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXKxNEDPxE1? M3LPflczKGh? MYjEUXNQ NX\keoM{UUN3ME2xNEDPxE1? M13YU|I{QDR2MEO4
EKVX MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\oNVAh|ryP MYW3NkBp NEC3eWRFVVOR NHHkZWpKSzVyPUGwJO69VQ>? NHzZXZUzOzh2NECzPC=>
FaDu MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWixNEDPxE1? MlPWO|IhcA>? M3\kc2ROW09? MVTJR|UxRTFyIN88US=> Mnm5NlM5PDRyM{i=
G401 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGxNEDPxE1? NVfNUIFMPzJiaB?= MVrEUXNQ NG\tOYRKSzVyPUGwJO69VQ>? M13zN|I{QDR2MEO4
HCC-70 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;zNVExKM7:TR?= MnjXO|IhcA>? M4T1d2ROW09? M1rZSmlEPTB;MUCg{txO MlTmNlM5PDRyM{i=
HCC-1954 NV;SNHpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXucm9kOTBizszN MmPTO|IhcA>? NHzLe4VFVVOR MVTJR|UxRTFyIN88US=> MV[yN|g1PDB|OB?=
Hela NGrzWY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\zblExKM7:TR?= NHf6NWg4OiCq MnHlSG1UVw>? MWTJR|UxRTFyIN88US=> M1\MblI{QDR2MEO4
Hep3B MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfSXZU6OTBizszN NFj2eW84OiCq MnTLSG1UVw>? Ml\CTWM2OD1zMDFOwG0> MlvaNlM5PDRyM{i=
HMCB NFzCc5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWexNEDPxE1? NITUTnQ4OiCq NH;LbJFFVVOR M3XQOmlEPTB;MUCg{txO NYPvXXZ{OjN6NESwN|g>
HN5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP4cGIyOCEQvF2= NETv[4I4OiCq NXHidY4yTE2VTx?= NFvwS3RKSzVyPUGwJO69VQ>? MlTvNlM5PDRyM{i=
HOS Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDtNVAh|ryP MoLRO|IhcA>? Mn3ISG1UVw>? MUnJR|UxRTFyIN88US=> MVWyN|g1PDB|OB?=
HPAF-II M3;sXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rjblExKM7:TR?= MUC3NkBp NXr1bGZGTE2VTx?= MkPCTWM2OD1zMDFOwG0> MXeyN|g1PDB|OB?=
Hs746.T MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUixNEDPxE1? NXOwXWtDPzJiaB?= M1LodGROW09? MnnhTWM2OD1zMDFOwG0> M1PWWlI{QDR2MEO4
HT NXr1e4tVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXKxNEDPxE1? NIXSZ3g4OiCq NILiUXdFVVOR NHuzOHNKSzVyPUGwJO69VQ>? NV32TYlwOjN6NESwN|g>
HT-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1O2NlExKM7:TR?= NFHMdZg4OiCq NWrvT4loTE2VTx?= MW\JR|UxRTFyIN88US=> M3L5flI{QDR2MEO4
HuNS-1 MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmxNEDPxE1? MXm3NkBp Mn\uSG1UVw>? NX;SfIxvUUN3ME2xNEDPxE1? MWiyN|g1PDB|OB?=
IGROV1 MlrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq2NVAh|ryP MmX0O|IhcA>? NGWzfVVFVVOR MXTJR|UxRTFyIN88US=> NH3NfoczOzh2NECzPC=>
J82 NISwRmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:0WIwyOCEQvF2= MnPQO|IhcA>? NUHOVXM1TE2VTx?= MWLJR|UxRTFyIN88US=> MUGyN|g1PDB|OB?=
JM1 M4nmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjPTo4yOCEQvF2= MWG3NkBp NFnybWJFVVOR MkPsTWM2OD1zMDFOwG0> Mn;GNlM5PDRyM{i=
Kato III MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPwfFV{OTBizszN NFrybJg4OiCq MXXEUXNQ M2WyW2lEPTB;MUCg{txO NVf3b3JsOjN6NESwN|g>
KHOS-240S Mn3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\ue2kyOCEQvF2= NFP2ZVM4OiCq MnjHSG1UVw>? NWLOWHJ4UUN3ME2xNEDPxE1? MWiyN|g1PDB|OB?=
KM-12 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13JU|ExKM7:TR?= MVu3NkBp NWDwSpBzTE2VTx?= M2ftSmlEPTB;MUCg{txO MW[yN|g1PDB|OB?=
KPL-1 M4fVWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHY[m1MOTBizszN MmDsO|IhcA>? NYDIe2NCTE2VTx?= NGflTG9KSzVyPUGwJO69VQ>? M4DHO|I{QDR2MEO4
KYSE-30 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTzNVAh|ryP MWO3NkBp M1;uc2ROW09? MX3JR|UxRTFyIN88US=> NGHEO2ozOzh2NECzPC=>
LNCaP M1\2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFX5R4MyOCEQvF2= NWjOU4t7PzJiaB?= Mlr6SG1UVw>? NXyxXVR{UUN3ME2xNEDPxE1? NXHFd2RCOjN6NESwN|g>
MCF-7 NUDBTmF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXqxNEDPxE1? NUPSZ41OPzJiaB?= MVzEUXNQ MYfJR|UxRTFyIN88US=> NIf5TIUzOzh2NECzPC=>
MC-IXC Mn;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDHNVAh|ryP NVXvdZJvPzJiaB?= M2P6V2ROW09? Ml3ZTWM2OD1zMDFOwG0> MmLjNlM5PDRyM{i=
MDA-MB-175 VII MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\3NVAh|ryP NIXxV3I4OiCq M1myZmROW09? MmfXTWM2OD1zMDFOwG0> NFfnT4wzOzh2NECzPC=>
MDA-MB-468 NYTDRpM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[xNEDPxE1? NYexZndZPzJiaB?= NEnuRolFVVOR M1q3PWlEPTB;MUCg{txO M{i5[VI{QDR2MEO4
MiaPaCa MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWxNEDPxE1? NW\Re2Z5PzJiaB?= M3TlXWROW09? MUHJR|UxRTFyIN88US=> NX;NfHZLOjN6NESwN|g>
Molt-4 NGTIZoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIeyW48yOCEQvF2= NHTLepU4OiCq M4\Je2ROW09? M1S1cGlEPTB;MUCg{txO MoLINlM5PDRyM{i=
NCI-ADR/RES NVzzO4tLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DXRVExKM7:TR?= M4\kZVczKGh? MVnEUXNQ NHTMNVFKSzVyPUGwJO69VQ>? MmrmNlM5PDRyM{i=
NCI-H69 M1XlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmxNZgyOCEQvF2= M1rrfVczKGh? NUHtT5dGTE2VTx?= MXPJR|UxRTFyIN88US=> M1X3clI{QDR2MEO4
NCI-H82 M1jpfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGn3Om8yOCEQvF2= NHK0[Wo4OiCq M3XWUWROW09? MXzJR|UxRTFyIN88US=> NUPqXFJWOjN6NESwN|g>
NCI-N87 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFi0RWoyOCEQvF2= MYG3NkBp MUTEUXNQ NEnKVXlKSzVyPUGwJO69VQ>? M{jjSVI{QDR2MEO4
NCI-H146 NWLPV4M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVexNEDPxE1? MmDMO|IhcA>? NH;YS5pFVVOR NVzXWYF1UUN3ME2xNEDPxE1? MVmyN|g1PDB|OB?=
NCI-H157 MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTIR3QyOCEQvF2= M3fyTFczKGh? Mof5SG1UVw>? NUHXWmpCUUN3ME2xNEDPxE1? NYjI[2h7OjN6NESwN|g>
NCI-H187 Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVyyVVM4OTBizszN MYO3NkBp NF3tV|JFVVOR MULJR|UxRTFyIN88US=> NX[1NXZzOjN6NESwN|g>
NCI-H209 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MliyNVAh|ryP NHHycVg4OiCq M1fPPGROW09? NIXoTHpKSzVyPUGwJO69VQ>? Mki5NlM5PDRyM{i=
NCI-H226 M1[3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz0d3kyOCEQvF2= NH\lSoQ4OiCq M3n6N2ROW09? MU\JR|UxRTFyIN88US=> NGO3U5YzOzh2NECzPC=>
NCI-H292 NIHUWZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHX[3MyOCEQvF2= MYK3NkBp NWXvSno3TE2VTx?= NE\BepBKSzVyPUGwJO69VQ>? NUT3U5VHOjN6NESwN|g>
NCI-H322 M3PUWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHXVJZXOTBizszN M3HkWlczKGh? M4TFXWROW09? M4XXWGlEPTB;MUCg{txO NFLkO20zOzh2NECzPC=>
NCI-H358 NIjmNpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPFOWhIOTBizszN NUPiWVR7PzJiaB?= MXfEUXNQ M3HYcWlEPTB;MUCg{txO NXf4fHI4OjN6NESwN|g>
NCI-H520 NEnuRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfHbYQyOCEQvF2= NFuyOZY4OiCq NF\FVIdFVVOR MmH0TWM2OD1zMDFOwG0> MoLhNlM5PDRyM{i=
NCI-H526 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWSxNEDPxE1? MnTCO|IhcA>? MXjEUXNQ M1jMemlEPTB;MUCg{txO MnnrNlM5PDRyM{i=
NCI-H630 NE\4W5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPaT28yOCEQvF2= MmD3O|IhcA>? MX\EUXNQ MVzJR|UxRTFyIN88US=> M{HX[FI{QDR2MEO4
NCI-H661 NYTYeGs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXUcZhQOTBizszN NW\z[mFvPzJiaB?= MUXEUXNQ Mn;ETWM2OD1zMDFOwG0> M3;pUlI{QDR2MEO4
NCI-H716 NYfvOHgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDxSoRIOTBizszN MWq3NkBp NYH5UoF2TE2VTx?= MlHtTWM2OD1zMDFOwG0> M2nGeFI{QDR2MEO4
NCI-H1563 NFHGRotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzUNVAh|ryP NFnQZWk4OiCq M4LycWROW09? M3PsOmlEPTB;MUCg{txO MlXqNlM5PDRyM{i=
NCI-H1792 NHrF[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;QSWFOOTBizszN NHvz[Xo4OiCq MkDySG1UVw>? MWXJR|UxRTFyIN88US=> M1fnUVI{QDR2MEO4
NCI-H2030 NXHpWIp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf3ZlY6OTBizszN MXK3NkBp NUW4[YNPTE2VTx?= M4L1VWlEPTB;MUCg{txO M4f0NFI{QDR2MEO4
NCI-H2052 NWDtSpBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX6xNEDPxE1? NFq0Z2E4OiCq Ml3jSG1UVw>? NY\kd4NjUUN3ME2xNEDPxE1? NVLuTI9XOjN6NESwN|g>
NCI-H2122 NEjnU4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC0NVAh|ryP MV63NkBp M1iy[2ROW09? MXTJR|UxRTFyIN88US=> NF64OoozOzh2NECzPC=>
NCI-H2228 NF7ObmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HpS|ExKM7:TR?= M{f5PVczKGh? MXXEUXNQ MX\JR|UxRTFyIN88US=> NWXRcmxwOjN6NESwN|g>
OE-19 M{jWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP5RlYxOTBizszN NUDlO2pMPzJiaB?= M3Lad2ROW09? MV7JR|UxRTFyIN88US=> M4L3flI{QDR2MEO4
OE-21 M1vtemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzrVo9YOTBizszN NHK4OVI4OiCq NXjpboNUTE2VTx?= NXvYcpFqUUN3ME2xNEDPxE1? NGDibXgzOzh2NECzPC=>
OE-33 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\UdWN7OTBizszN M4\iSlczKGh? NYPndZEzTE2VTx?= NVTDc4JmUUN3ME2xNEDPxE1? MoLYNlM5PDRyM{i=
OVCAR-3 MoCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnFNVAh|ryP M136XVczKGh? NVTUO3VYTE2VTx?= Ml7hTWM2OD1zMDFOwG0> MoDDNlM5PDRyM{i=
OVCAR-4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTwNVAh|ryP NX;D[lY4PzJiaB?= M3XTVmROW09? MofjTWM2OD1zMDFOwG0> MknYNlM5PDRyM{i=
OVCAR-5 M4D2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP4d29{OTBizszN NVrjU|VrPzJiaB?= NEHHOoxFVVOR NEf3NJdKSzVyPUGwJO69VQ>? M2HWUlI{QDR2MEO4
P3HR-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:xNEDPxE1? NELz[lY4OiCq MVfEUXNQ MUfJR|UxRTFyIN88US=> M3;qVlI{QDR2MEO4
PC-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\JNVAh|ryP NUC3fGtnPzJiaB?= NGHnNXdFVVOR MWHJR|UxRTFyIN88US=> MofwNlM5PDRyM{i=
Raji NHTCS5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILQXlIyOCEQvF2= MX23NkBp MYjEUXNQ MnTHTWM2OD1zMDFOwG0> M2\MUlI{QDR2MEO4
RD MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\SS|ExKM7:TR?= MnP4O|IhcA>? MUnEUXNQ MWrJR|UxRTFyIN88US=> M2HZNlI{QDR2MEO4
RD-ES NGrqPZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nRZ|ExKM7:TR?= MVW3NkBp MULEUXNQ Mn;KTWM2OD1zMDFOwG0> NFrYUnEzOzh2NECzPC=>
RL M{e0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrINVAh|ryP MU[3NkBp MWLEUXNQ MVXJR|UxRTFyIN88US=> M3vuN|I{QDR2MEO4
SaOS2 M4\TUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYOxNEDPxE1? M4foZVczKGh? MlPpSG1UVw>? MW\JR|UxRTFyIN88US=> M2qwVlI{QDR2MEO4
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SCC-12 NELlb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHmNVAh|ryP MVy3NkBp M1vMdGROW09? M{OxPGlEPTB;MUCg{txO MnnxNlM5PDRyM{i=
SCC-13 NYHUS2pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nnc|ExKM7:TR?= NVS3VIgyPzJiaB?= NHj2e4hFVVOR MX3JR|UxRTFyIN88US=> M3fZWlI{QDR2MEO4
SCC-15 NVm2elZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUSxNEDPxE1? MUG3NkBp MYXEUXNQ NXK2cWVlUUN3ME2xNEDPxE1? NUnRVWs{OjN6NESwN|g>
SCC-25 NYTONFlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHzOIMyOCEQvF2= MYK3NkBp M{C5bWROW09? MULJR|UxRTFyIN88US=> NV31dndZOjN6NESwN|g>
SCLC-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIGzcY4yOCEQvF2= MU[3NkBp NH7UcJpFVVOR MUTJR|UxRTFyIN88US=> M2CzdlI{QDR2MEO4
SF-268 NILicGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnSZ5J7OTBizszN NHvPd3I4OiCq NVzTT|VTTE2VTx?= NEHXRm5KSzVyPUGwJO69VQ>? M{PrZlI{QDR2MEO4
SF-295 NXfGZmwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVixNEDPxE1? M3H6ZlczKGh? MlfNSG1UVw>? MofwTWM2OD1zMDFOwG0> Ml7CNlM5PDRyM{i=
SJRH30 M{L5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL5e40yOCEQvF2= M4G3VlczKGh? NYDDbJFOTE2VTx?= MlPJTWM2OD1zMDFOwG0> NITQRYozOzh2NECzPC=>
SK-BR-3 NEj4dXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX3coIyOCEQvF2= Mlj2O|IhcA>? Mn7lSG1UVw>? NXT3TndYUUN3ME2xNEDPxE1? MUiyN|g1PDB|OB?=
SK-LMS-1 M2jNOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXNNVAh|ryP NF;WdoM4OiCq MlXJSG1UVw>? M3rrU2lEPTB;MUCg{txO MlToNlM5PDRyM{i=
SK-N-DZ NXnhUFYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVuxNEDPxE1? Ml\uO|IhcA>? NWfHZoJXTE2VTx?= M2WycWlEPTB;MUCg{txO MmjGNlM5PDRyM{i=
SK-N-F1 NEjCRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfVe4d4OTBizszN MnftO|IhcA>? MlrnSG1UVw>? M4mzbWlEPTB;MUCg{txO NF;4RlczOzh2NECzPC=>
SKOV-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn1NVAh|ryP NYX3XXZjPzJiaB?= MVrEUXNQ Mk[zTWM2OD1zMDFOwG0> NUfRcXpROjN6NESwN|g>
SK-UT-1 NIi1ZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XRPVExKM7:TR?= NYfvU4Y1PzJiaB?= NH;wPYtFVVOR MoPkTWM2OD1zMDFOwG0> M3zTZVI{QDR2MEO4
SN12C NV\tOYNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TzeVExKM7:TR?= MXW3NkBp MXnEUXNQ NWTmNZhWUUN3ME2xNEDPxE1? NF\OXFYzOzh2NECzPC=>
SNB-19 M4m3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm0NVAh|ryP MoOxO|IhcA>? NX;4SmJnTE2VTx?= MVvJR|UxRTFyIN88US=> Mlf3NlM5PDRyM{i=
SNU-5 Mm\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUSxNEDPxE1? MX:3NkBp NVHEWGw6TE2VTx?= M{C2RWlEPTB;MUCg{txO MnnnNlM5PDRyM{i=
SNU-16 NH;1U|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrHeIxpOTBizszN MnXtO|IhcA>? MWTEUXNQ M4rkcmlEPTB;MUCg{txO MYOyN|g1PDB|OB?=
SNU-398 NH\2XmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH60XZMyOCEQvF2= NUjq[2lXPzJiaB?= NE\obYRFVVOR MnXqTWM2OD1zMDFOwG0> M3;DO|I{QDR2MEO4
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ST486 NIi3PFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfaWlgyOCEQvF2= NXfPVZdoPzJiaB?= NIfteFZFVVOR NYG4Uo9VUUN3ME2xNEDPxE1? NHn2S3MzOzh2NECzPC=>
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SW684 MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\OcWcyOCEQvF2= M3G3U|czKGh? M{nZPWROW09? Mmi0TWM2OD1zMDFOwG0> MVSyN|g1PDB|OB?=
SW-780 NFmxU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUCxNEDPxE1? NV;5TIpiPzJiaB?= NYDWZnJYTE2VTx?= NHG4epRKSzVyPUGwJO69VQ>? NF[3RVUzOzh2NECzPC=>
SW900 NH7HU5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWGxNEDPxE1? MVO3NkBp NILFPYJFVVOR MlHCTWM2OD1zMDFOwG0> NFG4cogzOzh2NECzPC=>
SW1088 MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrTO2syOCEQvF2= NYm2RlhZPzJiaB?= M{LUNWROW09? NILDS3NKSzVyPUGwJO69VQ>? M2rBOFI{QDR2MEO4
SW1463 NFLLUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTpNVAh|ryP MlmxO|IhcA>? MYrEUXNQ NYfZZZFCUUN3ME2xNEDPxE1? NX72NVI4OjN6NESwN|g>
SW1990 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUSxNEDPxE1? M3\OXlczKGh? NHzBWZdFVVOR NVHLR2FRUUN3ME2xNEDPxE1? MXmyN|g1PDB|OB?=
T47D MmPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrze4cyOCEQvF2= NX:0TpZyPzJiaB?= NFHtbllFVVOR NVTETYduUUN3ME2xNEDPxE1? M2P6eVI{QDR2MEO4
TE381.T MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rmdVExKM7:TR?= M3HGelczKGh? NYXnVGhzTE2VTx?= MYHJR|UxRTFyIN88US=> MVyyN|g1PDB|OB?=
TK-10 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWKxNEDPxE1? NYfhR|JwPzJiaB?= NITYfGdFVVOR NVX3NWZQUUN3ME2xNEDPxE1? MViyN|g1PDB|OB?=
U2OS MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jDSlExKM7:TR?= NFT4c444OiCq M1f0UGROW09? MVfJR|UxRTFyIN88US=> M2qzZlI{QDR2MEO4
U251 NUTDWZNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIK3dG4yOCEQvF2= M1nRNVczKGh? M1XudmROW09? NVq3SoNxUUN3ME2xNEDPxE1? NXezUGNWOjN6NESwN|g>
UACC-812 MlPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XCdlExKM7:TR?= M4DYZlczKGh? NWDyU3M5TE2VTx?= NUnMd4p4UUN3ME2xNEDPxE1? NXniZ2ZIOjN6NESwN|g>
YAPC NYnrO4hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX6xNEDPxE1? MlrHO|IhcA>? M4D3WGROW09? NGTqXJRKSzVyPUGwJO69VQ>? NXXabJI5OjN6NESwN|g>
ZR-75-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2O0TVExKM7:TR?= MXO3NkBp M3vhbmROW09? MXvJR|UxRTFyIN88US=> MnnoNlM5PDRyM{i=
A375 MoG0SpVv[3Srb36gZZN{[Xl? NX70NWQ1OS5{IN88US=> M1P4bVQhcA>? Mki5SG1UVw>? M2H1R2lvcGmkaYTpc44hd2ZicHjvd5Bpd3K7bHH0bY9vKG:oIF3FT{whTVKNLDDhcoQhWz[S MXGyNlM5QTR5MR?=
YUSIT1 M2XPfGZ2dmO2aX;uJIF{e2G7 M13C[GROW09? M{HiR5Jm\HWlZXSgd4Vve2m2aY\peJkhf2m2aDDJR|UxKD5iMD61JO69VQ>? NF;nb|czOjN6OUS3NS=>
MeWo NH;OPHRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1;yO2ROW09? MXjJR|UxKD1iOUi3JI5O NXPEOGZGOjZyMUi1NlQ>
WiDr NHKxNWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTkSG1UVw>? M2XJVGlEPTBiPTC3OkBvVQ>? M{H6elI3ODF6NUK0
Colo-205 MY\GeY5kfGmxbjDhd5NigQ>? NGj4OJMyKM7:TR?= NWPIOWFxPCCm NG[zPVdFVVOR MVXJcoR2[2WmIHGgbIlocGy7IHPvcZBiemGkbHWgZ49ueGGldHnvckBxcGWwb4T5dIU> NV7RdoE3OjV|OEGxOVI>
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M257 NFXVOpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVGyVnFxOTByIH7N MXe3NkBp NYLoWlZGTG:nczDuc5QhcW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJG0zPTdiY3XscEBp[XKkb4XybY5oKHerbHSgeJlx\SCEUlHG M4PNSFI{OzF5NES2
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... Click to View More Cell Line Experimental Data

In vivo試験 Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]
臨床試験 Dabrafenib is currently in phase 3 clinical trial in patients with melanoma.
特集

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Dabrafenib (GSK2118436) SDF
分子量 519.56
化学式

C23H20F3N5O2S2

CAS No. 1195765-45-7
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (57.74 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

文献中の引用 (11)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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