Salinomycin 化学構造
分子量: 751.00

製品情報

製品の説明

生物活性

情報 Salinomycin is an anti-tumor antibiotic, and exhibits a selective inhibitory effect on cancer stem cells.
目標
IC50
LD50
In vitro試験 Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. [1] Salinomycin (Procoxacin) has been shown by Piyush Gupta to kill breast cancer stem cells at least 100 times more effectively than another popular anti-cancer compound (paclitaxel) in mice. [2] The mechanism of action by which salinomycin (Procoxacin) kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore due to the detection of Nigericin in the same compound screen. Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use.
In vivo試験 LD50: Mice 18mg/kg (i.p.), 50mg/kg (i.g.). [3]
臨床試験
特集

推薦された実験操作 (公開の文献だけ)

1

参考

化学情報

分子量 751.00
化学式

C42H70O11

CAS No. 53003-10-4
別名 Procoxacin
保管 2年 -20°C
6月-80°Cin DMSO
化学名

研究分野

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