Salinomycin 化学構造
分子量: 751.00

製品情報

製品の説明

生物活性

情報 Salinomycin is an anti-tumor antibiotic, and exhibits a selective inhibitory effect on cancer stem cells.
目標
IC50
LD50
In vitro試験 Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. [1] Salinomycin (Procoxacin) has been shown by Piyush Gupta to kill breast cancer stem cells at least 100 times more effectively than another popular anti-cancer compound (paclitaxel) in mice. [2] The mechanism of action by which salinomycin (Procoxacin) kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore due to the detection of Nigericin in the same compound screen. Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use.
In vivo試験 LD50: Mice 18mg/kg (i.p.), 50mg/kg (i.g.). [3]
臨床試験
特集

推薦された実験操作 (公開の文献だけ)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

分子量 751.00
化学式

C42H70O11

CAS No. 53003-10-4
保管 2年-20℃
6月-80℃in DMSO
別名 Procoxacin, AHR-3096
溶解度 (25°C) * In vitro DMSO 0.005 mg/mL (<1 mM)
0.01 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 Stereoisomer of α-ethyl-6-[5-[2-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]tetrahydro-5-methyl-2H-pyran-2-acetic acid

研究分野

技術サポート&よくある質問(FAQ)

顧客がするかもしれない質問に対する答えは、指示を取り扱っている阻害剤で見つかります。話題は、貯蔵液(阻害剤と特別な注意を細胞ベースの分析法と動物のために必要とする問題を保存することは実験します)を準備する方法を含みます。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の問い合わせをするならば、メッセージを残してください。

* 必須

Related その他

  • (S)-crizotinib

    (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

  • PTC-209

    PTC-209 is a potent and selective BMI-1 inhibitor, and results in irreversible reduction of cancer–initiating cells (CICs).

  • KN-93 Phosphate

    KN-93 H3PO4 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.

  • 4μ8C

    4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.

  • CX-4945 (Silmitasertib)

    CX-4945は、CK2αCK2α'の強力で選択的な阻害剤で、 IC50 が 1 nMです。

    Features:CX-4945是促进人类临床实验的CK2的第一个口服生物相容性小分子抑制剂。

  • Tacrolimus (FK506)

    FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.

  • Bendamustine HCl

    Bendamustine HCL (Ribomustin, Treanda, SDX-105)は、50μMのIC50をもつDNA有害なエージェントです。

    Features:Bendamustine已经批准用于治疗多种血液肿瘤,包括惰性和抗 Rituximab的NHL。

  • Cyclophosphamide Monohydrate

    Cyclophosphamide is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

  • Cabazitaxel

    Cabazitaxel(Jevtana、XRP6258)は、自然な税もどきの半合成派生物です。

    Features:Cabazitaxel是一种天然紫杉烷的半合成品衍生物。

  • Verteporfin

    Verteporfin(Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy.

最近見られたアイテム

Tags: Salinomycinを買う | Salinomycin供給者 | Salinomycinを購入する | Salinomycin費用 | Salinomycin生産者 | オーダーSalinomycin | Salinomycin代理店
お問い合わせ