OSI-906 (Linsitinib) 化学構造
分子量: 421.49

高品質保証

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Quality Control & MSDS

製品説明

  • Compare IGF-1R Inhibitors
    IGF-1R製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 OSI-906(Linsitinib)は、IGF-IRとIrの選択的な阻害剤で、IC50 がそれぞれ 35 nM と 75 nMです。
ターゲット IGF-1R InsR
IC50 35 nM 75 nM [1]
In vitro試験 OSI-906 inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 μM. OSI-906 enables an intermediate conformation of the target protein through interactions with the C-helix. OSI-906 displays favorable metabolic stability in liver microsomes. OSI-906 fully inhibits both IR and IGF-1R phosphorylation at a concentration of 1 μM. OSI-906 inhibits proliferation of several tumor cell lines including non-small-cell lung cancer and colorectal cancer (CRC) tumor cell line with EC50 of 0.021 to 0.810 μM. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A4-Fuk NVXUXY1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHUZm9KSzVyPUCuNFI5ODZizszN MkH6V2FPT0WU
KS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEO4N|Uh|ryP NEfKcnpUSU6JRWK=
TE-11 M2nNO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrxTWM2OD1yLkC3PFIzKM7:TR?= NYflXHRwW0GQR1XS
EW-1 M2f3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnVU4dKSzVyPUCuNFg2QDVizszN M2ezcXNCVkeHUh?=
HMV-II MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjSbnpKSzVyPUCuNFg5PDZizszN MYjTRW5ITVJ?
COLO-205 M3K5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWwT5lKSzVyPUCuNVA1PTRizszN MXTTRW5ITVJ?
ES1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUC2PVYh|ryP NFLBVXlUSU6JRWK=
GDM-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fme2lEPTB;MD6xN|Y4OiEQvF2= MUXTRW5ITVJ?
ML-2 M{\rfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPJfHZKSzVyPUCuNVU5QTZizszN MkPaV2FPT0WU
Saos-2 M4L5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\weop5UUN3ME2wMlE3PTJ4IN88US=> NIjpeIdUSU6JRWK=
NCI-H1355 NXva[ZJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj1TWM2OD1yLkG4NVM2KM7:TR?= M4Tq[3NCVkeHUh?=
G-401 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH5UHdKSzVyPUCuNVgzOyEQvF2= Mm\RV2FPT0WU
EW-16 MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMUi3O|ch|ryP NHPzO|hUSU6JRWK=
EW-7 M4\LSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPCTWM2OD1yLkG4PFgyKM7:TR?= NXTzb|ZbW0GQR1XS
NCI-H727 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTodIlKSzVyPUCuNVk4QTRizszN MnHWV2FPT0WU
LCLC-97TM1 Mn;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7CTWM2OD1yLkKwPVU2KM7:TR?= M3HVNnNCVkeHUh?=
NCI-H650 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPEdIVCUUN3ME2wMlIyOzh2IN88US=> NUfEfI9WW0GQR1XS
NCI-H2122 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\yTWM2OD1yLkKzNlk6KM7:TR?= M3;kSnNCVkeHUh?=
SK-N-DZ MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nrdGlEPTB;MD6yN|Y6QCEQvF2= NHPDW3RUSU6JRWK=
HT-29 NUGxWHVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMkSyOFgh|ryP MWnTRW5ITVJ?
LB771-HNC NH3qdIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMkW5NVUh|ryP NGj4NmJUSU6JRWK=
HT-144 MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrlTWM2OD1yLkK2NVkyKM7:TR?= NXjYTmtpW0GQR1XS
LAN-6 Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnOXW5KSzVyPUCuNlY{PDhizszN NYi0N5h4W0GQR1XS
EW-18 NUTv[IZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGj3ZY5KSzVyPUCuNlcxODFizszN NHrzV3lUSU6JRWK=
LS-1034 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHBTWM2OD1yLkK3NVMzKM7:TR?= NGr5PZhUSU6JRWK=
EW-11 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULTbZpQUUN3ME2wMlI5PDN{IN88US=> MXvTRW5ITVJ?
SNU-C1 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMkmzNVMh|ryP NXzLcYtwW0GQR1XS
RS4-11 MoOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnjeYxKSzVyPUCuN|M4PThizszN NV\XPGFWW0GQR1XS
ES4 NGDCcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLyTWM2OD1yLkSxNFM5KM7:TR?= MUjTRW5ITVJ?
COLO-320-HSR NFf5V|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7sdXhKSzVyPUCuOFE{PjhizszN MUTTRW5ITVJ?
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BFTC-905 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17o[2lEPTB;MD60Olc2QCEQvF2= NHTUboFUSU6JRWK=
A375 NWPy[GJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwNEe2NVch|ryP NHrSc4NUSU6JRWK=
SJRH30 MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPkW5lKSzVyPUCuOVA5OjJizszN MoPXV2FPT0WU
NOS-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrkOHVsUUN3ME2wMlUzOjZ5IN88US=> M4XE[HNCVkeHUh?=
SIG-M5 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDHTWM2OD1yLkWzOVU4KM7:TR?= NUXUT2t1W0GQR1XS
DOK NH25NVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fhemlEPTB;MD61OVYh|ryP MYjTRW5ITVJ?
NB69 M3TzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz4TWM2OD1yLkW4NlU4KM7:TR?= M4rm[nNCVkeHUh?=
SK-NEP-1 NHq4fINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrjbFdKSzVyPUCuOlAzOzZizszN NHLyXnRUSU6JRWK=
SK-MM-2 MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHxTWM2OD1yLk[1OFkyKM7:TR?= Mkm1V2FPT0WU
NCI-H358 NGf6UVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;iTWM2OD1yLk[3NFgzKM7:TR?= M1f5[HNCVkeHUh?=
RH-1 M4e5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rYSmlEPTB;MD63OFg2QSEQvF2= NHH2RWhUSU6JRWK=
NH-12 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17rNmlEPTB;MD63OlA1PiEQvF2= NULBfVZGW0GQR1XS
TE-12 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;WTWM2OD1yLke2OFg3KM7:TR?= NGTkTXFUSU6JRWK=
COLO-668 NYe2N5VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT5T3B2UUN3ME2wMlg1PjZ4IN88US=> MWDTRW5ITVJ?
PANC-08-13 M1LyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzGNVVKSzVyPUCuPFY{PzdizszN NWLY[GtQW0GQR1XS
HCC2998 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwOEiyOlMh|ryP M2XOO3NCVkeHUh?=
ABC-1 M3fLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLlUYNKSzVyPUCuPVA{PTJizszN M{XP[XNCVkeHUh?=
ES6 M2\pfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjLTWM2OD1yLkmxNFY3KM7:TR?= M3;UcXNCVkeHUh?=
SNU-387 M3\NfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPMTWM2OD1yLkm5N|k{KM7:TR?= MVXTRW5ITVJ?
CMK MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPubmZ3UUN3ME2wMlk6QTJ7IN88US=> MVzTRW5ITVJ?
SJSA-1 MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDBd5hJUUN3ME2xMlA{PjV|IN88US=> M3zrOHNCVkeHUh?=
SIMA M3joc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S0e2lEPTB;MT6wOlgzPSEQvF2= NWnjWmFQW0GQR1XS
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IGROV-1 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTFwMUW0OFQh|ryP NUT3e5d2W0GQR1XS
MEL-JUSO M{DUOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwMUW3OVkh|ryP M3rKUHNCVkeHUh?=
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CAL-85-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;2fnJOUUN3ME2xMlI{OTN6IN88US=> M3TUVnNCVkeHUh?=
RD NUnRcIxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[zdmlEPTB;MT6yOlQ2PSEQvF2= MUHTRW5ITVJ?
TE-8 M{DtWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXMN4l{UUN3ME2xMlMyPDZ{IN88US=> NYDZellvW0GQR1XS
L-363 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPWclFnUUN3ME2xMlM1OjB6IN88US=> M{PyeHNCVkeHUh?=
EKVX MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljhTWM2OD1zLkO0OVY5KM7:TR?= MWPTRW5ITVJ?
SK-MEL-3 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjRPGxvUUN3ME2xMlQ5PTV4IN88US=> M3TJSnNCVkeHUh?=
TGBC24TKB M4DCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j6T2lEPTB;MT61NFE6OyEQvF2= NYDJUnBCW0GQR1XS
NCI-H1770 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFwNUGxNVMh|ryP MXTTRW5ITVJ?
HuH-7 NF\OXZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFwNkCwPVgh|ryP MoThV2FPT0WU
HL-60 NVfOSHRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvZTWM2OD1zLk[2PVI5KM7:TR?= M3X0ZXNCVkeHUh?=
TE-1 NGS5fVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTPe5pKSzVyPUGuO|A6PDVizszN NFf1fWlUSU6JRWK=
LC-2-ad M1jp[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXKTWM2OD1zLkezPFg4KM7:TR?= MWnTRW5ITVJ?
LB647-SCLC NXzLb|ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX31cXhlUUN3ME2xMlc3PTh|IN88US=> NHjqTnFUSU6JRWK=
NCI-H2171 NYmyfXJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFq4fldKSzVyPUGuO|c4OTZizszN MVfTRW5ITVJ?
SK-PN-DW M1zCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTQTWM2OD1zLkmxNlk5KM7:TR?= MVvTRW5ITVJ?
MC-IXC NXvZOmxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rLOGlEPTB;MT65PFk5KM7:TR?= Ml[5V2FPT0WU
LS-513 M13tSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXqTIFlUUN3ME2yMlA2OzB3IN88US=> MYnTRW5ITVJ?
EW-3 M{XFSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[3TWM2OD1{LkC5PFQ1KM7:TR?= Mo\nV2FPT0WU
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CP66-MEL MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfQfVR3UUN3ME2yMlI6ODF2IN88US=> NVzCflh4W0GQR1XS
HCC1143 M2ixNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJwNEWzOlgh|ryP M2XkV3NCVkeHUh?=
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TE-10 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJwN{C4N|gh|ryP MmW4V2FPT0WU
NCI-H1882 NWO0N2x3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTJwN{WyNlch|ryP MlLHV2FPT0WU
CHP-126 NUnkUGRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TWeGlEPTB;Mj63OlMyPyEQvF2= NX3JO3RXW0GQR1XS
NCI-H1623 M4Lsbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJwOUKwNlQh|ryP M1TlRXNCVkeHUh?=
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RCC10RGB M4\rb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe2dnM1UUN3ME2yMlk2OjhzIN88US=> MXPTRW5ITVJ?
NCI-H2141 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDvTWM2OD1{Lkm2PFk3KM7:TR?= M1TVS3NCVkeHUh?=
GI-ME-N NUW5V|NrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHVe|NxUUN3ME2zMlAxPTZ3IN88US=> MmHRV2FPT0WU
NCI-H526 NWDFR5M{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n5Z2lEPTB;Mz6wOFA5PSEQvF2= MlXrV2FPT0WU
NCI-H747 Mk\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNwMES5PVIh|ryP NXXtdmxVW0GQR1XS
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DK-MG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fScWlEPTB;ND64NFk{OyEQvF2= NUTDTop5W0GQR1XS
OVCAR-5 MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnmTWM2OD12LkixNlI3KM7:TR?= M1\0O3NCVkeHUh?=
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CAPAN-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSwS41UUUN3ME21MlI2PzB5IN88US=> Ml7CV2FPT0WU
PSN1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTVwMkeyN|Uh|ryP NYf4WWt7W0GQR1XS
NCI-H292 M4r5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG1TWM2OD13LkOwNFQ1KM7:TR?= MXrTRW5ITVJ?
CPC-N NFTTfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTVwM{m0NVkh|ryP NFrP[HJUSU6JRWK=
DoTc2-4510 NYr6N2NUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDUTWM2OD13LkS1N|cyKM7:TR?= NEnMfXVUSU6JRWK=
LB1047-RCC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEWzUlRKSzVyPUWuOVU6OzNizszN NFTofmpUSU6JRWK=
MHH-ES-1 Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXoTVl4UUN3ME21MlU6QTB5IN88US=> NYPWeHVbW0GQR1XS
NMC-G1 M1XYc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7sTWM2OD13LkewNlI4KM7:TR?= MYnTRW5ITVJ?
SW1710 NUfkbG96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPBcYdKSzVyPUWuO|Q4PTFizszN MXLTRW5ITVJ?
YAPC NI\UUY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7QOVJWUUN3ME21Mlc3OjBzIN88US=> M4HrOnNCVkeHUh?=
22RV1 M1zZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTZTWM2OD13LkiwNFE6KM7:TR?= NVz6dZNoW0GQR1XS
COLO-679 MnPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm3cY1IUUN3ME21Mlg5QTR6IN88US=> NFjwb5BUSU6JRWK=
TCCSUP NFfROWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37sd2lEPTB;NT65N|I2QSEQvF2= NUH2PJdsW0GQR1XS
C2BBe1 NHnxUJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HYc2lEPTB;NT65N|k4KM7:TR?= MX\TRW5ITVJ?
TE-15 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;GTWM2OD14LkC2OlA2KM7:TR?= NFT1PHVUSU6JRWK=
SCLC-21H M4rmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fUWWlEPTB;Nj6xNFg1OyEQvF2= NVjrc4pvW0GQR1XS
EoL-1-cell MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTZwMU[1OlMh|ryP M2\x[XNCVkeHUh?=
NKM-1 NInme2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTZwMU[3NUDPxE1? NH:3ZZNUSU6JRWK=
NCI-H1304 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fuemlEPTB;Nj6yO|QzQCEQvF2= MmfFV2FPT0WU
NB6 NFHP[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4WwcGlEPTB;Nj6yPVYzOiEQvF2= MoLIV2FPT0WU
NALM-6 MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{npfGlEPTB;Nj6zN|I{KM7:TR?= MkXXV2FPT0WU
NCI-H522 MnSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjld3VKSzVyPU[uN|M{ODZizszN M{n6WnNCVkeHUh?=
MV-4-11 M4XhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGWyZndKSzVyPU[uN|cxPzlizszN M{Phe3NCVkeHUh?=
LB2241-RCC NVLwV49wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTZwM{i2Olch|ryP M3q0bnNCVkeHUh?=
NCI-H1417 M3HHcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTZwNEC4OFch|ryP MV7TRW5ITVJ?
HT-1197 NGHjUWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTZwNUexNlIh|ryP M2q1VXNCVkeHUh?=
P30-OHK M4TUe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPzZpZKSzVyPU[uOlI4PyEQvF2= MYnTRW5ITVJ?
ALL-PO NH;IblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;ZfJYxUUN3ME22MlcyQTF4IN88US=> MYPTRW5ITVJ?
OVCAR-4 NF3TcplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fVOGlEPTB;Nj63OVQxPSEQvF2= MU\TRW5ITVJ?
HCC2157 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTZwN{e0O|Uh|ryP NXXoPVJWW0GQR1XS
NCI-H838 MofnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn5XWxKSzVyPU[uPVY1QSEQvF2= M{HXTHNCVkeHUh?=
NCI-H1299 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTZwOUewPUDPxE1? MlHaV2FPT0WU
SW954 NUXyNVIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTdwMkCwOlgh|ryP MX3TRW5ITVJ?
NCI-H441 NUnoTIZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTdwM{SwOlUh|ryP M3Hw[HNCVkeHUh?=
SK-MEL-2 M{mwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDRe4tJUUN3ME23MlQ5Ozd|IN88US=> M1;IPXNCVkeHUh?=
KARPAS-45 MknuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTdwNkW5Nlkh|ryP NGHxcmtUSU6JRWK=
CAL-54 M3fLTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPx[oRDUUN3ME23MlgzQTd5IN88US=> MYfTRW5ITVJ?
KYSE-180 MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnBcJBKSzVyPUeuPFg6PDFizszN NHT0S4ZUSU6JRWK=
NCI-H187 NImxVnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn34TWM2OD15Lkm1PVQ4KM7:TR?= M2\rOHNCVkeHUh?=
RT-112 M2rldmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXP[JVKSzVyPUiuNFk3PzdizszN NIPOPFVUSU6JRWK=
NCI-H1437 MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rvZWlEPTB;OD6wPVc6PSEQvF2= NF\LbZZUSU6JRWK=
SNU-449 M3:2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj3R49KSzVyPUiuNlgzPzJizszN MnTVV2FPT0WU
HCC1187 NUTTWXFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\5TWM2OD16LkK5N|kyKM7:TR?= MWLTRW5ITVJ?
NCI-H2030 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjOTWM2OD16LkO3O|E1KM7:TR?= Mni4V2FPT0WU
HuO-3N1 NH3ISXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRThwM{e4OFQh|ryP M4TKOnNCVkeHUh?=
COLO-792 M3XJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHPPVRlUUN3ME24MlQyPTJ5IN88US=> NIrvd41USU6JRWK=
MIA-PaCa-2 NVjVeIdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDCTWM2OD16Lki1OVA5KM7:TR?= MVvTRW5ITVJ?
SK-N-FI NFjMXJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPwTWM2OD17LkC0NlUh|ryP NETFSolUSU6JRWK=
MMAC-SF NF;BcZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\rSVBUUUN3ME25MlA6PzVzIN88US=> NE\wZZNUSU6JRWK=
NCI-H28 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPMTWM2OD17LkGwOFY6KM7:TR?= NGLDdXVUSU6JRWK=
ETK-1 Mm[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvsNGVKSzVyPUmuNlk6PzRizszN NIT2TWRUSU6JRWK=
NCI-H1993 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjxRXc6UUN3ME25MlQ1OjZzIN88US=> MlziV2FPT0WU
no-11 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XKemlEPTB;OT60O|EzKM7:TR?= NYK4RmE1W0GQR1XS
ChaGo-K-1 M1fsb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID6V49KSzVyPUmuOVE2QDNizszN M3nFWHNCVkeHUh?=
NCCIT MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jGNGlEPTB;OT61N|E3QSEQvF2= MmDwV2FPT0WU
SAS NFfRbplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;DVJQ3UUN3ME2xNE4zPDhizszN MYHTRW5ITVJ?
A673 M{Ww[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;XTWM2OD1zMD6zO|A1KM7:TR?= M3fXVXNCVkeHUh?=
NCI-H1522 MoHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPzTWM2OD1zMD6zO|A4KM7:TR?= M{HtOnNCVkeHUh?=
NCI-H810 NXu0b|drT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3qzZ2lEPTB;MUCuN|kxPyEQvF2= NH\zSotUSU6JRWK=
IST-MES1 NWDSTmdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFyLkS1OlQh|ryP MVjTRW5ITVJ?
GR-ST NG\HUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHXTWM2OD1zMD61NFI1KM7:TR?= MnnpV2FPT0WU
SUP-T1 M2[xT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrze2pKSzVyPUGwMlc{OTdizszN NVLWWVFKW0GQR1XS
NB5 NGfDdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjJTWM2OD1zMD65NFIzKM7:TR?= NF[3NFRUSU6JRWK=
MZ1-PC M2fkd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFyLkm1O|Eh|ryP MWPTRW5ITVJ?
SK-CO-1 NFyzbGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP1TWM2OD1zMD65PVMyKM7:TR?= NHz0WnNUSU6JRWK=
Capan-2 NYLtc|l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\sTWM2OD1zMT6zNVk5KM7:TR?= Mn36V2FPT0WU
697 M3qzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fxeWlEPTB;MUGuOlc2PyEQvF2= MnHLV2FPT0WU
REH MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHlRVZiUUN3ME2xNU44PDVzIN88US=> NWn1[JF4W0GQR1XS
GI-1 MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFzLki2NVUh|ryP NVrkTmJJW0GQR1XS
BB65-RCC NYHISpBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mny5TWM2OD1zMj6wPVE3KM7:TR?= MmnrV2FPT0WU
NCI-H1651 NHrJWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHaVm9KSzVyPUGyMlI1PzhizszN MmLtV2FPT0WU
NCI-H1618 M1r1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTF{LkO5O|Yh|ryP NF3hVXZUSU6JRWK=
NCI-H2081 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT4U5YxUUN3ME2xNk43OTRzIN88US=> M13ZVXNCVkeHUh?=
GCIY NV\OZYt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnH[|ZKSzVyPUGyMlczOTNizszN NEDk[nNUSU6JRWK=
NY NHLvWWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonETWM2OD1zMz6wOlQ{KM7:TR?= NVHGV2VKW0GQR1XS
PANC-03-27 M{X3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33YNmlEPTB;MUOuNFgxPyEQvF2= NFnP[olUSU6JRWK=
BHY NVrQ[5FWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTF|LkKxNlEh|ryP MoDxV2FPT0WU
SK-OV-3 M1\BW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfkTWM2OD1zMz6zO|Y{KM7:TR?= M3;tS3NCVkeHUh?=
5637 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv6RlZKSzVyPUGzMlc4PTlizszN MlvpV2FPT0WU
LC-1F NXrBZZRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTF2LkCzOVYh|ryP Moj5V2FPT0WU
SNB75 NGnZfVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO5foNKSzVyPUG0MlA{QDNizszN MmW2V2FPT0WU
CHP-212 NVvoTHZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;zcGlEPTB;MUSuNFQ3PCEQvF2= MnG1V2FPT0WU
HT-1376 M1fXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[3TWM2OD1zND6xNVI3KM7:TR?= MmfCV2FPT0WU
MONO-MAC-6 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe0UJNtUUN3ME2xOE4yPTB{IN88US=> M{O4bnNCVkeHUh?=
CA46 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\Y[pRKSzVyPUG0MlE5OjdizszN NVXlbGpJW0GQR1XS
SCC-15 M1XOdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\PbFN2UUN3ME2xOE42PTh|IN88US=> M2TMcHNCVkeHUh?=
ATN-1 NYe0VJJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfEO5hEUUN3ME2xOE43PjJ5IN88US=> MnnqV2FPT0WU
NCI-H2405 NW\5fm5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTQTWM2OD1zND64NVU4KM7:TR?= M4nUenNCVkeHUh?=
NCI-H716 Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUj3eZZnUUN3ME2xOE45PDl|IN88US=> NIm1elNUSU6JRWK=
SW620 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLwdocyUUN3ME2xOE46ODF2IN88US=> NVjHSo9uW0GQR1XS
NCI-H226 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonTTWM2OD1zND65NFg2KM7:TR?= M2TEUnNCVkeHUh?=
SW962 M1HFe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37PbGlEPTB;MUSuPVQ{OiEQvF2= NEPrNYFUSU6JRWK=
KYSE-150 NXG5WoJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLEflhKSzVyPUG0Mlk2PSEQvF2= NIrCcW9USU6JRWK=
OCUB-M NGD0RllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX0Z5FKSzVyPUG0Mlk5QDNizszN NH;1cYNUSU6JRWK=
ES7 NXHGV4QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvJTWM2OD1zNT6wPVg1KM7:TR?= MYPTRW5ITVJ?
SW1463 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPBTWM2OD1zNT60NlI{KM7:TR?= NGLjTmlUSU6JRWK=
CAKI-1 NXnQUIFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XIe2lEPTB;MUWuOVM1PiEQvF2= NEK5O|RUSU6JRWK=
MKN28 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnNTo1xUUN3ME2xOU42PDd7IN88US=> MkXRV2FPT0WU
SW13 M2S2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXyUGE{UUN3ME2xOU43OThizszN M13QW3NCVkeHUh?=
A3-KAW MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjufWJVUUN3ME2xOU46Pjl5IN88US=> NYPaUWRNW0GQR1XS
LU-65 M4DYcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG5TWM2OD1zNT65O|Y5KM7:TR?= NH3ifXBUSU6JRWK=
Calu-1 M1\nZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLKTWM2OD1zNj6wN|Y5KM7:TR?= MVnTRW5ITVJ?
ST486 M2niVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DmWWlEPTB;MU[uNFQ{OSEQvF2= MmDrV2FPT0WU
BB30-HNC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LOe2lEPTB;MU[uNVI1PiEQvF2= MX7TRW5ITVJ?
EGI-1 NYG0[mVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj6UHZCUUN3ME2xOk41PDZizszN NV\WOoV1W0GQR1XS
SH-4 M1jiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofSTWM2OD1zNj60O|MyKM7:TR?= NVHvRXRHW0GQR1XS
MN-60 NUjPb5JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTF5LkKyPVch|ryP MYHTRW5ITVJ?
MPP-89 NVzLbnNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH1eJBUUUN3ME2xO{4zPDV7IN88US=> M{Lxd3NCVkeHUh?=
A2780 MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPabFRKSzVyPUG3MlQyOzlizszN MXrTRW5ITVJ?
Daoy MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF5LkS2PVUh|ryP NX3ncZkxW0GQR1XS
NCI-H2126 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYCydIlNUUN3ME2xO{41PzdzIN88US=> NYrLRZl5W0GQR1XS
NCI-H1563 MorvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF5LkS5NVch|ryP MXrTRW5ITVJ?
8-MG-BA NYjiZoRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H1W2lEPTB;MUeuOlY1QCEQvF2= NF3mSVBUSU6JRWK=
786-0 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILJZ5FKSzVyPUG3Mlg{PTNizszN NFjSSYtUSU6JRWK=
AM-38 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzyTWM2OD1zNz65N|A3KM7:TR?= MlXkV2FPT0WU
COLO-824 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfseIJPUUN3ME2xPE41PDN4IN88US=> NWD3NWV6W0GQR1XS
SK-MEL-30 MnT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLKTWM2OD1zOD61NFgzKM7:TR?= NYjTNpM6W0GQR1XS
CESS MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2OxUmlEPTB;MUiuO|YxQSEQvF2= NWr5d41qW0GQR1XS
BL-70 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfFZodKSzVyPUG4MlgyPTZizszN M2PsZ3NCVkeHUh?=
NCI-H2170 M33JfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP2TWM2OD1zOD65NVc6KM7:TR?= NUHQeldyW0GQR1XS
HT-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3QT|IxUUN3ME2xPE46QDNizszN MV7TRW5ITVJ?
BOKU M4ixPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXwRXVKSzVyPUG5MlA{QDFizszN M1vHUHNCVkeHUh?=
HPAF-II NF7nZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TOXGlEPTB;MUmuN|AyPSEQvF2= NHmyXlhUSU6JRWK=
KGN MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTF7LkS3OlUh|ryP MX7TRW5ITVJ?
MC-CAR NVXjT3V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\yfJF[UUN3ME2xPU43OzF|IN88US=> NXvRXHZPW0GQR1XS
BHT-101 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi2cZRKSzVyPUG5Mlc4PyEQvF2= NGftS|NUSU6JRWK=
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SR MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTN6LkW0PVUh|ryP M3mySXNCVkeHUh?=
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SK-HEP-1 NX:0UFNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW0fFEzUUN3ME2zPE44QDJ{IN88US=> M{nlS3NCVkeHUh?=
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NCI-H1755 NHr5bHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nkVmlEPTB;M{muOVgyPyEQvF2= NWL5bIJXW0GQR1XS
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MOLT-4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILaNJJKSzVyPUSwMlI6ODFizszN M3:zO3NCVkeHUh?=
AsPC-1 M{nHUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDxVoJKSzVyPUSwMlQ2QDNizszN MlTPV2FPT0WU
HOP-62 M2LGb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXHR2FoUUN3ME20NE43PTZ6IN88US=> NFHtb3dUSU6JRWK=
A172 Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrzeldKSzVyPUSwMlg2OTFizszN NVixfIhWW0GQR1XS
SN12C M2nMZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHVXohYUUN3ME20NE46Ozh3IN88US=> M{PYbnNCVkeHUh?=
MDA-MB-231 MkLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrRTWM2OD12MD65PFk5KM7:TR?= NUHxRWFWW0GQR1XS
RPMI-2650 NWHJe|czT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXDTWM2OD12MT6xOVk{KM7:TR?= NVPMUFZVW0GQR1XS
KYSE-140 NWnhT3hPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXEXHhyUUN3ME20NU45OTJ|IN88US=> MWHTRW5ITVJ?
KINGS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4H5VWlEPTB;NEKuOFY6PyEQvF2= MVrTRW5ITVJ?
HSC-3 M2frSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LMbWlEPTB;NEKuOlY3OSEQvF2= NUD4dZVyW0GQR1XS
PC-14 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTR|LkG4PFIh|ryP NYfvV4d2W0GQR1XS
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BE-13 MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrsTWM2OD12ND6yN|cyKM7:TR?= MUTTRW5ITVJ?
NCI-H661 M4LsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTR2LkK5OVgh|ryP Mlv3V2FPT0WU
IST-MEL1 NYjN[2RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfP[JBKSzVyPUS0MlM2QTlizszN MnXSV2FPT0WU
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COLO-800 Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XoR2lEPTB;NESuPFQ2OyEQvF2= NIm4enlUSU6JRWK=
IST-SL2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PH[2lEPTB;NEWuNVI1PyEQvF2= NW\GNZlDW0GQR1XS
8305C Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXGxN28yUUN3ME20OU4{ODlizszN NX\hSGRNW0GQR1XS
UACC-62 MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nofmlEPTB;NE[uNlg4PSEQvF2= Mn32V2FPT0WU
COR-L23 NWWwdWxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXkTWM2OD12Nz6xPVkh|ryP MV7TRW5ITVJ?
EFE-184 NVm0TZM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTR5LkO4PEDPxE1? NUfWWJplW0GQR1XS
DMS-114 MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TBRmlEPTB;NEeuOFE1QSEQvF2= M3n0cHNCVkeHUh?=
KYSE-520 Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfp[lFKSzVyPUS4MlU{OTVizszN MonBV2FPT0WU
SNG-M M{jLT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnETWM2OD12OT60N|Qh|ryP NV73[3p5W0GQR1XS
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... Click to View More Cell Line Experimental Data

In vivo試験 OSI-906 inhibits tumor growth in an IGF-1R-driven xenograft mouse model, with 100% TGI and 55% regression at a dose of 75 mg/kg and 60% TGI and no regression at a dose of 25 mg/kg. OSI-906 administration induces different elimination half-lives of itself in dog, rat and mice, the elimination half-lives are 1.18 hours, 2.64 hours and 2.14 hours, respectively. OSI-906 administration at different single dose once-daily in femal Sprague-Dawley rat and femal CD-1 mouse reveal that the Vmax is not dose-proportional to OSI-906 dose. OSI-906 elevates the blood glucose levels at a dose of 25 mg/kg after 12 days administration. OSI-906 administration at a single dose of 75 mg/kg in IGF-1R-driven full-length human IGF-1R (LISN) xenograft mouse model achieve maximal inhibition of IGF-1R phosphorylation (80%) between 4 and 24 hours with plasma drug concentrations of 26.6-4.77 μM. [1] OSI-906 administered as a single dose of at 60 mg/kg in NCI-H292 xenografts mice inhibits uptake of glucose at 2, 4, and 24 hours post-treatment in vivo. OSI-906 inhibits the growth of tumors in NCI-H292 xenograft mouse model. [2]
臨床試験 OSI-906 is currently under a Phase III clinical trial in adrenocortical carcinoma (ACC).
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Protein kinase biochemical assays Protein kinase assays are either performed in-house by ELISA-based assay methods (IGF-1R, IR, EGFR and KDR) or at Upstate Inc. by a radiometric method with ATP at 100 µM concentration. In-house ELISA assays use poly(Glu:Tyr) as the substrate bound to the surface of 96-well assay plates and phosphorylation is detected using an antiphosphotyrosine antibody conjugated to horseradish peroxidase. The bound antibody is quantified using ABTS as the peroxidase substrate by measuring absorbance at 405 / 490 nm. All assays use purified recombinant kinase catalytic domains. Recombinant enzymes of human IGF-1R or EGFR are expressed as an NH2-terminal glutathione S-transferase fusion protein in insect cells and are purified in house. IC50 values are determined from the sigmoidal dose–response plot of percent inhibition versus log10 compound concentration. A minimum of three measurements, performed in duplicate, are carried out with in-house assays unless otherwise indicated. OSI-906 at a concentration of 1 µM is profiled versus a panel of kinases using the ProfilerProTM Kinase Selectivity Assay Kit.

細胞アッセイ: [1]

細胞株 MCF7, NCI-H292, Colo-205, HT29, H358, H1703, BxPC3, A673, SW620, DU4475, HepG2 and Hepa-1, RKO 3T3/hulGF-IR and H292 cells
濃度 0.02-0.8 μM
反応時間 3 days
実験の流れ For assays of cell proliferation, cells are seeded into 96-well plates in appropriate media containing FCS 10% and incubated for 3 days in the presence of OSI-906 at various concentrations. Inhibition of cell growth is determined by luminescent quantitation of intracellular ATP content using CellTiterGlo. Data is presented as a fraction of maximal proliferation, calculated by dividing the cellular density in the presence of varying concentrations of OSI-906 by the cellular density of control cells treated with vehicle (DMSO) only.

動物実験: [1]

動物モデル IGF-1R-driven full-length human IGF-1R (LISN) xenograft mouse model
製剤 25 mM tartaric acid
投薬量 25 mg / kg and 75 mg / kg
投与方法 Orally administrated at once-daily oral dose for 14 days

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download OSI-906 (Linsitinib) SDF
分子量 421.49
化学式

C26H23N5O

CAS No. 867160-71-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 84 mg/mL (199.29 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 30mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol

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