OSI-906 (Linsitinib) 化学構造
分子量: 421.49

高品質保証

カスタマーフィードバック(3)

Quality Control & MSDS

製品説明

  • Compare IGF-1R Inhibitors
    IGF-1R製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 OSI-906(Linsitinib)は、IGF-IRとIrの選択的な阻害剤で、IC50 がそれぞれ 35 nM と 75 nMです。
ターゲット IGF-1R InsR
IC50 35 nM 75 nM [1]
In vitro試験 OSI-906 inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 μM. OSI-906 enables an intermediate conformation of the target protein through interactions with the C-helix. OSI-906 displays favorable metabolic stability in liver microsomes. OSI-906 fully inhibits both IR and IGF-1R phosphorylation at a concentration of 1 μM. OSI-906 inhibits proliferation of several tumor cell lines including non-small-cell lung cancer and colorectal cancer (CRC) tumor cell line with EC50 of 0.021 to 0.810 μM. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A4-Fuk M{XzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEK4NFYh|ryP NX:yVGJyW0GQR1XS
KS-1 NVXsfJBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTDSHFvUUN3ME2wMlA{QDN3IN88US=> MVPTRW5ITVJ?
TE-11 NEnx[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnm2TWM2OD1yLkC3PFIzKM7:TR?= M{Xo[HNCVkeHUh?=
EW-1 M3XpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEi1PFUh|ryP MXrTRW5ITVJ?
HMV-II NXfnd2FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX34dYh2UUN3ME2wMlA5QDR4IN88US=> NWq2fXZ6W0GQR1XS
COLO-205 NE\mXFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e2UGlEPTB;MD6xNFQ2PCEQvF2= NFnVNFhUSU6JRWK=
ES1 MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qxfmlEPTB;MD6xNFY6PiEQvF2= MmCyV2FPT0WU
GDM-1 NH7R[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\RbmlEPTB;MD6xN|Y4OiEQvF2= MXPTRW5ITVJ?
ML-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj4NXFKSzVyPUCuNVU5QTZizszN MnjBV2FPT0WU
Saos-2 NHrSdo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD5TWM2OD1yLkG2OVI3KM7:TR?= MULTRW5ITVJ?
NCI-H1355 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\lV4dKSzVyPUCuNVgyOzVizszN MXfTRW5ITVJ?
G-401 NGS5UW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljjTWM2OD1yLkG4NlMh|ryP M4fCXHNCVkeHUh?=
EW-16 NUfqVVRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPXTWM2OD1yLkG4O|c4KM7:TR?= NY\td2R[W0GQR1XS
EW-7 MonQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMUi4PFEh|ryP M2jC[HNCVkeHUh?=
NCI-H727 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnSTWM2OD1yLkG5O|k1KM7:TR?= NU\mWphFW0GQR1XS
LCLC-97TM1 MkLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMkC5OVUh|ryP NIrHNIFUSU6JRWK=
NCI-H650 NVPMdHR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTBcJQ2UUN3ME2wMlIyOzh2IN88US=> NIfp[4pUSU6JRWK=
NCI-H2122 NV7HcpVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTseGk6UUN3ME2wMlI{Ojl7IN88US=> NU\oW2lWW0GQR1XS
SK-N-DZ NVPhO5k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP4SpFKSzVyPUCuNlM3QThizszN MXjTRW5ITVJ?
HT-29 NFzTT3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv4TWM2OD1yLkK0NlQ5KM7:TR?= Ml\BV2FPT0WU
LB771-HNC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIKzbHhKSzVyPUCuNlU6OTVizszN NWjF[nV6W0GQR1XS
HT-144 NHf5dm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjlWXJKSzVyPUCuNlYyQTFizszN NVjxTnBuW0GQR1XS
LAN-6 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMk[zOFgh|ryP NVHlfJVNW0GQR1XS
EW-18 Mlj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e1W2lEPTB;MD6yO|AxOSEQvF2= NYrj[5hQW0GQR1XS
LS-1034 NV\CeVBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[2bYNOUUN3ME2wMlI4OTN{IN88US=> M1TQU3NCVkeHUh?=
EW-11 M1XidWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHDTWM2OD1yLkK4OFMzKM7:TR?= NU\mTHFSW0GQR1XS
SNU-C1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXSOGh7UUN3ME2wMlI6OzF|IN88US=> NETFZoFUSU6JRWK=
RS4-11 NIK0cGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHCTlFMUUN3ME2wMlM{PzV6IN88US=> M3jie3NCVkeHUh?=
ES4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGm0PYdKSzVyPUCuOFExOzhizszN M4fWc3NCVkeHUh?=
COLO-320-HSR NHjISXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL3TWM2OD1yLkSxN|Y5KM7:TR?= MnL0V2FPT0WU
NB10 Mn3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjUbGE1UUN3ME2wMlQ2PDN5IN88US=> MYLTRW5ITVJ?
BFTC-905 NF3vem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoiwTWM2OD1yLkS2O|U5KM7:TR?= MnvvV2FPT0WU
A375 NI\xdm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rEU2lEPTB;MD60O|YyPyEQvF2= NYjCWJd2W0GQR1XS
SJRH30 NWfyVIJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwNUC4NlIh|ryP M1fVXXNCVkeHUh?=
NOS-1 M33NNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojNTWM2OD1yLkWyNlY4KM7:TR?= Mm[1V2FPT0WU
SIG-M5 NITV[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37EcWlEPTB;MD61N|U2PyEQvF2= MmO3V2FPT0WU
DOK MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDGWndxUUN3ME2wMlU2PiEQvF2= NYLifoNVW0GQR1XS
NB69 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG3VoxKSzVyPUCuOVgzPTdizszN MnryV2FPT0WU
SK-NEP-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C5[GlEPTB;MD62NFI{PiEQvF2= M1LmZnNCVkeHUh?=
SK-MM-2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6weYVMUUN3ME2wMlY2PDlzIN88US=> M4D5OXNCVkeHUh?=
NCI-H358 MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHtVZRmUUN3ME2wMlY4ODh{IN88US=> NIjWSGpUSU6JRWK=
RH-1 NV7L[WVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j6cmlEPTB;MD63OFg2QSEQvF2= M{\IXHNCVkeHUh?=
NH-12 NX3FXIV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV32VIZ5UUN3ME2wMlc3ODR4IN88US=> M3\YenNCVkeHUh?=
TE-12 M3PvSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH5WHZKSzVyPUCuO|Y1QDZizszN NULEN29yW0GQR1XS
COLO-668 NVTBNGZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHoTWM2OD1yLki0OlY3KM7:TR?= NVHOWHgyW0GQR1XS
PANC-08-13 NHLIcJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vMcGlEPTB;MD64OlM4PyEQvF2= MUnTRW5ITVJ?
HCC2998 MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoiwTWM2OD1yLki4NlY{KM7:TR?= Mkj4V2FPT0WU
ABC-1 NUGw[FV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\rU2lEPTB;MD65NFM2OiEQvF2= NFrE[WVUSU6JRWK=
ES6 NHPZU|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi2epBVUUN3ME2wMlkyODZ4IN88US=> NFPx[HBUSU6JRWK=
SNU-387 NYDlfJJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwOUmzPVMh|ryP NVmxOXViW0GQR1XS
CMK Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwOUm5Nlkh|ryP MlHTV2FPT0WU
SJSA-1 NXriTIlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwMEO2OVMh|ryP M3rZNHNCVkeHUh?=
SIMA MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7KTWM2OD1zLkC2PFI2KM7:TR?= MVvTRW5ITVJ?
ES3 MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\jZWlEPTB;MT6xNlI6PyEQvF2= NGDUVpBUSU6JRWK=
IGROV-1 Ml7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLjbJN2UUN3ME2xMlE2PDR2IN88US=> NYW4W3k6W0GQR1XS
MEL-JUSO MoT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TuW2lEPTB;MT6xOVc2QSEQvF2= NIrt[FRUSU6JRWK=
T84 M3jMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHrSotuUUN3ME2xMlIxQTF2IN88US=> M4f0O3NCVkeHUh?=
CAL-85-1 NGLx[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjwbZVVUUN3ME2xMlI{OTN6IN88US=> NIW5b2FUSU6JRWK=
RD MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELqV2xKSzVyPUGuNlY1PTVizszN NEfSUmtUSU6JRWK=
TE-8 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rPZ2lEPTB;MT6zNVQ3OiEQvF2= M4SyS3NCVkeHUh?=
L-363 NXXEOlBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwM{SyNFgh|ryP MmnwV2FPT0WU
EKVX MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHwZVlKSzVyPUGuN|Q2PjhizszN NVS2O2V4W0GQR1XS
SK-MEL-3 NHPGUnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\J[5VKSzVyPUGuOFg2PTZizszN M3TMd3NCVkeHUh?=
TGBC24TKB M2PTc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH62ZY9KSzVyPUGuOVAyQTNizszN MXXTRW5ITVJ?
NCI-H1770 NFrm[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTwTWM2OD1zLkWxNVE{KM7:TR?= M2C5dHNCVkeHUh?=
HuH-7 M13ZNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDBTWM2OD1zLk[wNFk5KM7:TR?= M37xcXNCVkeHUh?=
HL-60 M3PDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTzWVhqUUN3ME2xMlY3QTJ6IN88US=> NFHQWJhUSU6JRWK=
TE-1 NIfCeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\BNWJKSzVyPUGuO|A6PDVizszN M130VHNCVkeHUh?=
LC-2-ad MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFwN{O4PFch|ryP MYTTRW5ITVJ?
LB647-SCLC MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwN{[1PFMh|ryP NWX2R|BQW0GQR1XS
NCI-H2171 NGn1U|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;STWM2OD1zLke3O|E3KM7:TR?= Ml;vV2FPT0WU
SK-PN-DW MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTm[WdyUUN3ME2xMlkyOjl6IN88US=> MVLTRW5ITVJ?
MC-IXC M3SxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LCbWlEPTB;MT65PFk5KM7:TR?= MYPTRW5ITVJ?
LS-513 NWr5SoE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXnTWM2OD1{LkC1N|A2KM7:TR?= MWDTRW5ITVJ?
EW-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfqNpRJUUN3ME2yMlA6QDR2IN88US=> MlTHV2FPT0WU
OPM-2 M{jESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTJwMUCyJO69VQ>? MX;TRW5ITVJ?
LP-1 M1Pp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nT[GlEPTB;Mj6yOVgxPyEQvF2= NELSR2tUSU6JRWK=
LU-134-A MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;QWmxIUUN3ME2yMlI4PyEQvF2= NYnsV215W0GQR1XS
CP66-MEL MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD1bZBqUUN3ME2yMlI6ODF2IN88US=> M1vGcnNCVkeHUh?=
HCC1143 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjBXHgzUUN3ME2yMlQ2OzZ6IN88US=> NGLIcIVUSU6JRWK=
LOXIMVI MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJwNkCyNUDPxE1? MVvTRW5ITVJ?
TE-10 NFfXOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL5RY84UUN3ME2yMlcxQDN6IN88US=> NUTo[XNLW0GQR1XS
NCI-H1882 M1;KWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTJwN{WyNlch|ryP NF\H[GhUSU6JRWK=
CHP-126 M1fHTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITPbmtKSzVyPUKuO|Y{OTdizszN MlfDV2FPT0WU
NCI-H1623 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\ndHFKSzVyPUKuPVIxOjRizszN MVvTRW5ITVJ?
GB-1 M3XuPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPJTWM2OD1{LkmzOFA1KM7:TR?= M2PBT3NCVkeHUh?=
RCC10RGB M1vFfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIeyVGtKSzVyPUKuPVUzQDFizszN M3HQTnNCVkeHUh?=
NCI-H2141 M2XqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJwOU[4PVYh|ryP M4rZS3NCVkeHUh?=
GI-ME-N MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTNwMEC1OlUh|ryP NYS0NW5zW0GQR1XS
NCI-H526 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;GTWM2OD1|LkC0NFg2KM7:TR?= MVjTRW5ITVJ?
NCI-H747 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTNwMES5PVIh|ryP NHn5N21USU6JRWK=
SNU-423 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i5fWlEPTB;Mz6yNFMyOyEQvF2= MnTMV2FPT0WU
A427 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTNwMkW2PVkh|ryP MlPCV2FPT0WU
CAL-12T NFT4dYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESxPXhKSzVyPUOuOFA4OTNizszN NX7JTVl1W0GQR1XS
LU-99A NXO1b|BnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DJe2lEPTB;Mz60O|ExPSEQvF2= M2DVc3NCVkeHUh?=
MS-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LwNWlEPTB;Mz61N|QzQSEQvF2= MnT5V2FPT0WU
SK-LU-1 MmrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm4WpRKSzVyPUOuO|YzQTVizszN NHHjbWJUSU6JRWK=
SW837 MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTNwN{[zN|Mh|ryP NGPmPGlUSU6JRWK=
ES8 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPiRWxQUUN3ME2zMlg{QDd5IN88US=> NYHkcpVSW0GQR1XS
MZ2-MEL M4jwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\kfnFwUUN3ME2zMlkzODh4IN88US=> MkHmV2FPT0WU
TGW M3f6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjxN4JKSzVyPUSuNFE{OTFizszN MX7TRW5ITVJ?
GP5d M2SwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTRwMEWzOlIh|ryP M32zN3NCVkeHUh?=
BB49-HNC NG\Rb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLwTWM2OD12LkG1NlE{KM7:TR?= MXPTRW5ITVJ?
NB13 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTRwMk[4PFch|ryP NFvTbJRUSU6JRWK=
NTERA-S-cl-D1 M2fINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTRwMki2NVUh|ryP M3XGcHNCVkeHUh?=
NCI-H1648 M2GxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTRwMkm4NVkh|ryP NF7tZ2JUSU6JRWK=
LCLC-103H MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTRwM{KxPVUh|ryP MY\TRW5ITVJ?
LS-411N NXTjUVdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTRwNES4PFUh|ryP MVXTRW5ITVJ?
NCI-H1092 MoewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j1d2lEPTB;ND60OVY5PyEQvF2= MVHTRW5ITVJ?
PANC-10-05 Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLObpE1UUN3ME20MlY6QDRizszN NFe5VmlUSU6JRWK=
DK-MG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfUTWM2OD12LkiwPVM{KM7:TR?= NGqwU4xUSU6JRWK=
OVCAR-5 NGDDbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTufoN{UUN3ME20MlgyOjJ4IN88US=> MVvTRW5ITVJ?
CAL-39 NXPNTVdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTRwOEe2O{DPxE1? NGW3WplUSU6JRWK=
TE-441-T NV3renpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTRwOUC1N|ch|ryP MULTRW5ITVJ?
MOLT-16 NVH5e5JoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnzVlVlUUN3ME20Mlk2OjV|IN88US=> NGPyXoRUSU6JRWK=
MCF7 M3yw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPWd|hnUUN3ME21MlE1PTF5IN88US=> MXzTRW5ITVJ?
CAPAN-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;KTWM2OD13LkK1O|A4KM7:TR?= MlrTV2FPT0WU
PSN1 NYjWSngzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HLeWlEPTB;NT6yO|I{PSEQvF2= MkGzV2FPT0WU
NCI-H292 MlraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX5TWM2OD13LkOwNFQ1KM7:TR?= NGjWTXhUSU6JRWK=
CPC-N NYjOfo8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\YXFRNUUN3ME21MlM6PDF7IN88US=> MXnTRW5ITVJ?
DoTc2-4510 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWO1O2k6UUN3ME21MlQ2OzdzIN88US=> M1zoOHNCVkeHUh?=
LB1047-RCC NEO2OG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD0RndLUUN3ME21MlU2QTN|IN88US=> M4m2THNCVkeHUh?=
MHH-ES-1 MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkWyTWM2OD13LkW5PVA4KM7:TR?= NEf5W2xUSU6JRWK=
NMC-G1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjsZmxKSzVyPUWuO|AzOjdizszN MojLV2FPT0WU
SW1710 NWW3e|hST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHCTHl1UUN3ME21Mlc1PzVzIN88US=> MnyyV2FPT0WU
YAPC MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT1ZoJKSzVyPUWuO|YzODFizszN M3LtfnNCVkeHUh?=
22RV1 NV\iO4lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzjcXBSUUN3ME21MlgxODF7IN88US=> M4fSd3NCVkeHUh?=
COLO-679 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HDfGlEPTB;NT64PFk1QCEQvF2= NXjrZXpSW0GQR1XS
TCCSUP M{TkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fxfGlEPTB;NT65N|I2QSEQvF2= NELSS2pUSU6JRWK=
C2BBe1 NW\hc3NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf1XYJKSzVyPUWuPVM6PyEQvF2= NYHCeFRFW0GQR1XS
TE-15 NVzrbHd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzNelFKSzVyPU[uNFY3ODVizszN NX;ZcHpoW0GQR1XS
SCLC-21H M1nIN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD5TWM2OD14LkGwPFQ{KM7:TR?= MkK2V2FPT0WU
EoL-1-cell M2HScmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rvTmlEPTB;Nj6xOlU3OyEQvF2= NGXQbmRUSU6JRWK=
NKM-1 NH\aVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX6TWM2OD14LkG2O|Eh|ryP M{eybnNCVkeHUh?=
NCI-H1304 M4S5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzjSFg4UUN3ME22MlI4PDJ6IN88US=> MlKyV2FPT0WU
NB6 NYHiV3ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW0TWM2OD14LkK5OlIzKM7:TR?= MVzTRW5ITVJ?
NALM-6 MkXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfadHRKSzVyPU[uN|MzOyEQvF2= NFPPXnFUSU6JRWK=
NCI-H522 NGfjNHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTZwM{OzNFYh|ryP MXXTRW5ITVJ?
MV-4-11 MmLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTMTWM2OD14LkO3NFc6KM7:TR?= MUXTRW5ITVJ?
LB2241-RCC MmjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f1WGlEPTB;Nj6zPFY3PyEQvF2= M4TtXnNCVkeHUh?=
NCI-H1417 NW\TVHBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTZwNEC4OFch|ryP M3rHdXNCVkeHUh?=
HT-1197 MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTZwNUexNlIh|ryP M{DRNHNCVkeHUh?=
P30-OHK NFHNZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTZwNkK3O{DPxE1? MnHwV2FPT0WU
ALL-PO MoS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTZwN{G5NVYh|ryP Mne4V2FPT0WU
OVCAR-4 MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfsTWM2OD14Lke1OFA2KM7:TR?= MXfTRW5ITVJ?
HCC2157 M3X3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTZwN{e0O|Uh|ryP Mmj3V2FPT0WU
NCI-H838 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlu3TWM2OD14Lkm2OFkh|ryP NFLBc5JUSU6JRWK=
NCI-H1299 NWe0ZmJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;semlEPTB;Nj65O|A6KM7:TR?= NILNTINUSU6JRWK=
SW954 NVnmfmF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrvV45KSzVyPUeuNlAxPjhizszN NWj4cJlFW0GQR1XS
NCI-H441 Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXOdWpKSzVyPUeuN|QxPjVizszN NGjZU4ZUSU6JRWK=
SK-MEL-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3VTWM2OD15LkS4N|c{KM7:TR?= NWXJ[JlSW0GQR1XS
KARPAS-45 NXjvV|BnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTdwNkW5Nlkh|ryP M1;vZnNCVkeHUh?=
CAL-54 NI\tUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTdwOEK5O|ch|ryP M1rjcnNCVkeHUh?=
KYSE-180 NWnmNIs4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DUW2lEPTB;Nz64PFk1OSEQvF2= MWTTRW5ITVJ?
NCI-H187 M3Gy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37adWlEPTB;Nz65OVk1PyEQvF2= NWfGcnl5W0GQR1XS
RT-112 NIrEcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH6WnQ4UUN3ME24MlA6Pjd5IN88US=> MYnTRW5ITVJ?
NCI-H1437 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLkNWhmUUN3ME24MlA6Pzl3IN88US=> M3\neXNCVkeHUh?=
SNU-449 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nsTGlEPTB;OD6yPFI4OiEQvF2= MWrTRW5ITVJ?
HCC1187 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\JTWM2OD16LkK5N|kyKM7:TR?= NIPncYZUSU6JRWK=
NCI-H2030 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;wWmlEPTB;OD6zO|cyPCEQvF2= M3vkPHNCVkeHUh?=
HuO-3N1 NUnzWIMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17C[WlEPTB;OD6zO|g1PCEQvF2= MUTTRW5ITVJ?
COLO-792 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRThwNEG1Nlch|ryP MWPTRW5ITVJ?
MIA-PaCa-2 NHrkfFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PGcGlEPTB;OD64OVUxQCEQvF2= MVTTRW5ITVJ?
SK-N-FI M2XOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HpcWlEPTB;OT6wOFI2KM7:TR?= NIfvUJVUSU6JRWK=
MMAC-SF Mne3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XoZWlEPTB;OT6wPVc2OSEQvF2= MXvTRW5ITVJ?
NCI-H28 NEfyW2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2wTWM2OD17LkGwOFY6KM7:TR?= MUDTRW5ITVJ?
ETK-1 M1TFZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrZTWM2OD17LkK5PVc1KM7:TR?= MULTRW5ITVJ?
NCI-H1993 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDOZ4ZUUUN3ME25MlQ1OjZzIN88US=> MUfTRW5ITVJ?
no-11 NFHrWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmOwTWM2OD17LkS3NVIh|ryP MWfTRW5ITVJ?
ChaGo-K-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DDc2lEPTB;OT61NVU5OyEQvF2= MW\TRW5ITVJ?
NCCIT MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlmwTWM2OD17LkWzNVY6KM7:TR?= MUnTRW5ITVJ?
SAS MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofkTWM2OD1zMD6yOFgh|ryP M2PScHNCVkeHUh?=
A673 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHSTWM2OD1zMD6zO|A1KM7:TR?= M3fsN3NCVkeHUh?=
NCI-H1522 NGDzNJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnnT2lIUUN3ME2xNE4{PzB5IN88US=> MnrlV2FPT0WU
NCI-H810 M2rBSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknJTWM2OD1zMD6zPVA4KM7:TR?= NUm4dYo1W0GQR1XS
IST-MES1 NYnY[2F2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPiPXM4UUN3ME2xNE41PTZ2IN88US=> MXPTRW5ITVJ?
GR-ST M{PJN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PRcGlEPTB;MUCuOVAzPCEQvF2= MlHuV2FPT0WU
SUP-T1 NXjjOXI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG5S4lKSzVyPUGwMlc{OTdizszN MX3TRW5ITVJ?
NB5 M2LaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\0TWM2OD1zMD65NFIzKM7:TR?= M{fIdXNCVkeHUh?=
MZ1-PC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTkU3FKSzVyPUGwMlk2PzFizszN M2nwW3NCVkeHUh?=
SK-CO-1 MmLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\EfYJKSzVyPUGwMlk6OzFizszN NXTMfFZJW0GQR1XS
Capan-2 NX;zUYNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTFzLkOxPVgh|ryP NVXlOWU1W0GQR1XS
697 M4jvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\hXmpKSzVyPUGxMlY4PTdizszN MljuV2FPT0WU
REH NFLkdnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoC0TWM2OD1zMT63OFUyKM7:TR?= M4LxW3NCVkeHUh?=
GI-1 NVPtdZVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfvTWM2OD1zMT64OlE2KM7:TR?= M3m1[3NCVkeHUh?=
BB65-RCC MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;3TGlEPTB;MUKuNFkyPiEQvF2= M4HRPXNCVkeHUh?=
NCI-H1651 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTF{LkK0O|gh|ryP MVzTRW5ITVJ?
NCI-H1618 NEj6SG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGCwcZVKSzVyPUGyMlM6PzZizszN M13IdXNCVkeHUh?=
NCI-H2081 NGLFSFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXRXJJKSzVyPUGyMlYyPDFizszN NH:4WGVUSU6JRWK=
GCIY Mnn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m4cWlEPTB;MUKuO|IyOyEQvF2= NUfkdWhMW0GQR1XS
NY NW[5N2c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHqWHhlUUN3ME2xN{4xPjR|IN88US=> MV;TRW5ITVJ?
PANC-03-27 NUSzfZI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jOdGlEPTB;MUOuNFgxPyEQvF2= NU\vSoxiW0GQR1XS
BHY NWHoS|dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDoOpdsUUN3ME2xN{4zOTJzIN88US=> MVHTRW5ITVJ?
SK-OV-3 NHHKdYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTF|LkO3OlMh|ryP M1XTXXNCVkeHUh?=
5637 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKzUnhyUUN3ME2xN{44PzV7IN88US=> MkTJV2FPT0WU
LC-1F NG\QU5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOyVoxKSzVyPUG0MlA{PTZizszN MWPTRW5ITVJ?
SNB75 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3vR3VKSzVyPUG0MlA{QDNizszN MXLTRW5ITVJ?
CHP-212 NVjiVoQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXwcVJWUUN3ME2xOE4xPDZ2IN88US=> NW\HU4pwW0GQR1XS
HT-1376 NUWzTolyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3xTWM2OD1zND6xNVI3KM7:TR?= M3Xj[XNCVkeHUh?=
MONO-MAC-6 NEjLUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe2NHp6UUN3ME2xOE4yPTB{IN88US=> MmfaV2FPT0WU
CA46 M{PBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDHUpNKSzVyPUG0MlE5OjdizszN NGHyWXVUSU6JRWK=
SCC-15 M4Dkfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fuU2lEPTB;MUSuOVU5OyEQvF2= NF3lZpJUSU6JRWK=
ATN-1 NYTmOFg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDxO3ROUUN3ME2xOE43PjJ5IN88US=> NVzzPIRHW0GQR1XS
NCI-H2405 MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlGzTWM2OD1zND64NVU4KM7:TR?= M1zhOXNCVkeHUh?=
NCI-H716 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjhTnhNUUN3ME2xOE45PDl|IN88US=> NXPZUXJIW0GQR1XS
SW620 M4n2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP5OIJKSzVyPUG0MlkxOTRizszN NWHTN5IxW0GQR1XS
NCI-H226 M3LXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmi5TWM2OD1zND65NFg2KM7:TR?= MX3TRW5ITVJ?
SW962 M3T4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTXUWliUUN3ME2xOE46PDN{IN88US=> NUHPcnZoW0GQR1XS
KYSE-150 MleyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTF2Lkm1OUDPxE1? Mnm4V2FPT0WU
OCUB-M MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF2Lkm4PFMh|ryP Ml73V2FPT0WU
ES7 NWDD[mhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf5THFoUUN3ME2xOU4xQTh2IN88US=> MnzSV2FPT0WU
SW1463 M1[yVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTF3LkSyNlMh|ryP MYnTRW5ITVJ?
CAKI-1 M1PST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXibW5KSzVyPUG1MlU{PDZizszN NYnCUVdYW0GQR1XS
MKN28 NEPDSJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL0TWM2OD1zNT61OFc6KM7:TR?= MUfTRW5ITVJ?
SW13 NV3YcVlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoixTWM2OD1zNT62NVgh|ryP MXLTRW5ITVJ?
A3-KAW Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTF3Lkm2PVch|ryP MUnTRW5ITVJ?
LU-65 M3\3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjSV3VQUUN3ME2xOU46PzZ6IN88US=> NEG0NJlUSU6JRWK=
Calu-1 M1rxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fsemlEPTB;MU[uNFM3QCEQvF2= M4jiSHNCVkeHUh?=
ST486 Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHSTWM2OD1zNj6wOFMyKM7:TR?= MYHTRW5ITVJ?
BB30-HNC Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF4LkGyOFYh|ryP NIXMfpFUSU6JRWK=
EGI-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX1[HI{UUN3ME2xOk41PDZizszN MX3TRW5ITVJ?
SH-4 NXrpfJRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LYS2lEPTB;MU[uOFc{OSEQvF2= M4T2T3NCVkeHUh?=
MN-60 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHizV25KSzVyPUG3MlIzQTdizszN M1X3OHNCVkeHUh?=
MPP-89 M2HsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXPWnhPUUN3ME2xO{4zPDV7IN88US=> Ml7lV2FPT0WU
A2780 NHH5VYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jPc2lEPTB;MUeuOFE{QSEQvF2= NVG4Vm5HW0GQR1XS
Daoy M3;Pfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fycWlEPTB;MUeuOFY6PSEQvF2= NEmwbVlUSU6JRWK=
NCI-H2126 MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF5LkS3O|Eh|ryP M1;KSHNCVkeHUh?=
NCI-H1563 NHruPWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXDUFA5UUN3ME2xO{41QTF5IN88US=> NEjhToNUSU6JRWK=
8-MG-BA MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\4OWlEPTB;MUeuOlY1QCEQvF2= M3nIcnNCVkeHUh?=
786-0 M1\LbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTF5LkizOVMh|ryP NVvPRZBVW0GQR1XS
AM-38 MkXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTF5LkmzNFYh|ryP NI\Oeo5USU6JRWK=
COLO-824 MkLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7ETWM2OD1zOD60OFM3KM7:TR?= M3n5VXNCVkeHUh?=
SK-MEL-30 NYG1NopQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3kd4JsUUN3ME2xPE42ODh{IN88US=> NWjIV5g2W0GQR1XS
CESS NYDUU3BqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\JTWM2OD1zOD63OlA6KM7:TR?= NYTBeGZKW0GQR1XS
BL-70 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTF6LkixOVYh|ryP M3TmSnNCVkeHUh?=
NCI-H2170 M3jrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M321XWlEPTB;MUiuPVE4QSEQvF2= MlnMV2FPT0WU
HT-3 NEXYb|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTOTWM2OD1zOD65PFMh|ryP NWPafm1[W0GQR1XS
BOKU MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rpSmlEPTB;MUmuNFM5OSEQvF2= MkTYV2FPT0WU
HPAF-II MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGX2ZnlKSzVyPUG5MlMxOTVizszN Mn36V2FPT0WU
KGN NYDDT5pxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3pWo5NUUN3ME2xPU41PzZ3IN88US=> MmHYV2FPT0WU
MC-CAR NXTwWnBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXyTWM2OD1zOT62N|E{KM7:TR?= MmnQV2FPT0WU
BHT-101 NFTNcJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz6bI1KSzVyPUG5Mlc4PyEQvF2= NVzle3VEW0GQR1XS
SW1783 NHTmWWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTF7Lke4NFYh|ryP MXPTRW5ITVJ?
KP-N-YN MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJyLkCyOlIh|ryP NX7oSohFW0GQR1XS
LU-165 M2PQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH35V5hKSzVyPUKwMlU2PzFizszN MnTDV2FPT0WU
GOTO NUDZTolHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJyLk[0OVEh|ryP MnTGV2FPT0WU
EFM-19 M1TXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\icmxKSzVyPUKxMlA4OTZizszN MUXTRW5ITVJ?
CTV-1 MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVS2PItpUUN3ME2yNU4yODV2IN88US=> NXX6No17W0GQR1XS
HEL NGLnWZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nnbmlEPTB;MkGuOFIyPiEQvF2= MXHTRW5ITVJ?
SNU-C2B MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;YfYNKSzVyPUKxMlQzPiEQvF2= Mo\MV2FPT0WU
ECC4 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LXfmlEPTB;MkGuO|A4KM7:TR?= NVrXTJhRW0GQR1XS
NEC8 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XTR2lEPTB;MkGuPFM3QCEQvF2= M1Hwc3NCVkeHUh?=
KMOE-2 M3TSemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvzTWM2OD1{MT64PVIyKM7:TR?= MXvTRW5ITVJ?
NCI-H524 M2ftVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fSPWlEPTB;MkKuNFgxQCEQvF2= MVfTRW5ITVJ?
WSU-NHL NVf5OWFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfDTWM2OD1{Mj6xOVc4KM7:TR?= M{npT3NCVkeHUh?=
SF126 NV7SZZdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL1[FRKSzVyPUKyMlI1PjlizszN M2CyT3NCVkeHUh?=
HOP-92 Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXZNlJqUUN3ME2yNk4{OTZ5IN88US=> NVz2bJlmW0GQR1XS
CTB-1 M1\UUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfBOXV6UUN3ME2yNk41Pjd5IN88US=> NX64S4dbW0GQR1XS
KYSE-270 NFm0TGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrweYdKSzVyPUKyMlk{PTdizszN M1;nb3NCVkeHUh?=
SK-MEL-24 NYLmcVhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjITWM2OD1{Mz6xPFch|ryP NF;mXnhUSU6JRWK=
Calu-3 M3XVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJ|LkKxNlgh|ryP NFWzboRUSU6JRWK=
GAMG Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHMTWM2OD1{Mz6yN|Y4KM7:TR?= NXnjPXhGW0GQR1XS
SW1573 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L3SmlEPTB;MkOuO|QyPSEQvF2= NUmzSGhGW0GQR1XS
MHH-NB-11 M2PPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJ2LkCxPVQh|ryP NUXEe5lVW0GQR1XS
TK10 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJ2LkWwNVMh|ryP M{fLbHNCVkeHUh?=
LB373-MEL-D Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJ2Lk[wOlQh|ryP MWLTRW5ITVJ?
KALS-1 MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFntepZKSzVyPUK0Mlc{OjdizszN NV[1XmlLW0GQR1XS
HUTU-80 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJ3LkiwN|Ih|ryP NITrfolUSU6JRWK=
HuP-T3 M2DQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H2[GlEPTB;Mk[uNVY4PCEQvF2= NYnBWGhsW0GQR1XS
OE19 NF7mN45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnftTWM2OD1{Nj6yNVU{KM7:TR?= MVvTRW5ITVJ?
J82 NYrWZ5RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\aeYlTUUN3ME2yOk4zPDdzIN88US=> M4XCbXNCVkeHUh?=
DU-4475 NUfBfFV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ThUGlEPTB;Mk[uN|gyQSEQvF2= M1\ZdHNCVkeHUh?=
DMS-53 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJ4LkWxN|gh|ryP NF7uVnJUSU6JRWK=
COLO-741 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f0OWlEPTB;Mk[uPFM1PCEQvF2= NWH2[JJKW0GQR1XS
SW48 MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fSbmlEPTB;Mk[uPFgzKM7:TR?= NUDrS5AzW0GQR1XS
IGR-1 M2q3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJ4LkmzN|Qh|ryP M17UO3NCVkeHUh?=
639-V M4TodWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEn0dpBKSzVyPUK3MlAzPDVizszN Mn3zV2FPT0WU
LK-2 M3XYRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjkTWM2OD1{Nz60NVQyKM7:TR?= MnTnV2FPT0WU
NCI-H2347 Mn7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PlZmlEPTB;MkeuPVY6QSEQvF2= MXLTRW5ITVJ?
NCI-H2228 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i2NWlEPTB;MkiuNFkxPSEQvF2= NIP4VXhUSU6JRWK=
LS-123 M33pb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTWOIJTUUN3ME2yPE4yOjZ{IN88US=> NUjqV4hqW0GQR1XS
U031 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJ6LkK1NkDPxE1? MWjTRW5ITVJ?
NCI-H1792 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHhUW5KSzVyPUK4MlQ4OjFizszN M2H5PXNCVkeHUh?=
NCI-H2087 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPITWM2OD1{OD63OVUzKM7:TR?= NFXReodUSU6JRWK=
NCI-H2342 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETEeo9KSzVyPUK5MlUzODhizszN NIjwT5BUSU6JRWK=
SW626 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGzTWM2OD1{OT63OVYh|ryP MVTTRW5ITVJ?
LB2518-MEL MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmK1TWM2OD1{OT64NVUh|ryP MmPjV2FPT0WU
RXF393 NXXkN5ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M12wb2lEPTB;M{CuNFk2OiEQvF2= NInvenBUSU6JRWK=
LC4-1 NHLJUndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[xb3dKSzVyPUOwMlMxQTJizszN NFf3cIdUSU6JRWK=
NCI-H1694 NIL0bW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTNyLk[2NlQh|ryP M3LXeXNCVkeHUh?=
K5 MljBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nVdmlEPTB;M{CuPVcxOiEQvF2= MYLTRW5ITVJ?
HDLM-2 NUO4NnBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYe1TG8xUUN3ME2zNE46PzJ3IN88US=> NF[w[o9USU6JRWK=
BCPAP MoDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Lv[2lEPTB;M{GuPFM4QSEQvF2= NVTNS|h6W0GQR1XS
BC-3 MmHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\4[|hKSzVyPUOyMlE1ODNizszN NUTzSY1EW0GQR1XS
LB996-RCC NVzjRYZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTN{LkKzOVgh|ryP MnrSV2FPT0WU
NCI-H2009 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN{LkS5PFEh|ryP NWPJbItjW0GQR1XS
HTC-C3 M4\Kb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPJTWM2OD1|Mz63OVE6KM7:TR?= MoPLV2FPT0WU
LAMA-84 NXXjSGx[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVS0XVhHUUN3ME2zOE41PDB5IN88US=> MWHTRW5ITVJ?
CCRF-CEM NH\H[JVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPRTWM2OD1|ND61O|E2KM7:TR?= M{XqbnNCVkeHUh?=
AN3-CA NXG3eJJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTN3LkC1Olgh|ryP NH7r[mxUSU6JRWK=
NCI-H1734 M17OTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTN3LkK1OlEh|ryP NHrwe3dUSU6JRWK=
Ca-Ski M2rGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfUTWM2OD1|NT60NVAyKM7:TR?= NWe4OFBYW0GQR1XS
U-266 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGCwVJFKSzVyPUO1MlYyOTRizszN NVqyU21VW0GQR1XS
SBC-5 NGrLbItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTPSZpKSzVyPUO1Mlc4QDFizszN M16zVXNCVkeHUh?=
GT3TKB NIP3VXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTN5LkGxOUDPxE1? NWTZW|NIW0GQR1XS
MDA-MB-175-VII NGDTd3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTN5LkKyOFgh|ryP M1rxR3NCVkeHUh?=
PFSK-1 MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLFTWM2OD1|Nz6yOFM2KM7:TR?= M4DWS3NCVkeHUh?=
IMR-5 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfCe5ZYUUN3ME2zO{4zPDh5IN88US=> NIDxWpRUSU6JRWK=
Daudi NUjUbXhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTN5LkO1PVch|ryP NFzCT|RUSU6JRWK=
A498 NXzDXFlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXTTWM2OD1|Nz63NlE5KM7:TR?= NWfT[45ZW0GQR1XS
SCC-4 M2PEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH4ZZZHUUN3ME2zO{44QDR|IN88US=> NHjNcm1USU6JRWK=
COLO-680N NVzMfIpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTN6LkK4PFUh|ryP M2PFT3NCVkeHUh?=
SK-MES-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XkT2lEPTB;M{iuN|IyPSEQvF2= MWfTRW5ITVJ?
SR NHfU[4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PQd2lEPTB;M{iuOVQ6PSEQvF2= MV;TRW5ITVJ?
LNCaP-Clone-FGC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHNSZY5UUN3ME2zPE42PjN5IN88US=> M1;LXXNCVkeHUh?=
SK-HEP-1 NXf3UXBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\2c|NpUUN3ME2zPE44QDJ{IN88US=> NFPUd4VUSU6JRWK=
BPH-1 M16yR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPiNYdKSzVyPUO4Mlg{OjlizszN NVzh[ndUW0GQR1XS
NCI-H1755 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jt[GlEPTB;M{muOVgyPyEQvF2= NXuzRmhqW0GQR1XS
LXF-289 MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvlTnZKSzVyPUO5MlgxQDRizszN NFzHfG1USU6JRWK=
SW1088 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\uUGlEPTB;NECuNlExPyEQvF2= MYPTRW5ITVJ?
MOLT-4 NXP3RpFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:xTWM2OD12MD6yPVAyKM7:TR?= NELWPY9USU6JRWK=
AsPC-1 NWL5VGNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTRyLkS1PFMh|ryP MUHTRW5ITVJ?
HOP-62 M3\MWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jJZ2lEPTB;NECuOlU3QCEQvF2= MkTaV2FPT0WU
A172 NXfpRpRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nMSWlEPTB;NECuPFUyOSEQvF2= Mo\mV2FPT0WU
SN12C NXWwPWxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTISohKSzVyPUSwMlk{QDVizszN MkTNV2FPT0WU
MDA-MB-231 MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LUR2lEPTB;NECuPVg6QCEQvF2= NHzTO|dUSU6JRWK=
RPMI-2650 NYTCSG9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTRzLkG1PVMh|ryP NVKxXItoW0GQR1XS
KYSE-140 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XBS2lEPTB;NEGuPFEzOyEQvF2= NYHTZ|NuW0GQR1XS
KINGS-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHSwd5BKSzVyPUSyMlQ3QTdizszN NYDibpRkW0GQR1XS
HSC-3 M{HnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTR{Lk[2OlEh|ryP NWrX[HlbW0GQR1XS
PC-14 NIHzcWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7jTWM2OD12Mz6xPFgzKM7:TR?= MVrTRW5ITVJ?
COR-L105 M2Dad2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17Ke2lEPTB;NEOuOlUxOiEQvF2= MVzTRW5ITVJ?
BE-13 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTR2LkKzO|Eh|ryP MULTRW5ITVJ?
NCI-H661 M4XmNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLpU4dlUUN3ME20OE4zQTV6IN88US=> MVXTRW5ITVJ?
IST-MEL1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE[xbW9KSzVyPUS0MlM2QTlizszN NVvLRYFFW0GQR1XS
HCC1806 NFf3Z2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DrNWlEPTB;NESuOVg4OyEQvF2= MlK3V2FPT0WU
COLO-800 MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP3TWM2OD12ND64OFU{KM7:TR?= MonsV2FPT0WU
IST-SL2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXvTWM2OD12NT6xNlQ4KM7:TR?= Mki1V2FPT0WU
8305C M2nKOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTR3LkOwPUDPxE1? NXfQVW5WW0GQR1XS
UACC-62 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjRTWM2OD12Nj6yPFc2KM7:TR?= MUTTRW5ITVJ?
COR-L23 NXrSNpY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH6zZo5KSzVyPUS3MlE6QSEQvF2= MVLTRW5ITVJ?
EFE-184 Mm\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rVVmlEPTB;NEeuN|g5KM7:TR?= NV\vXHByW0GQR1XS
DMS-114 M1\CWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTR5LkSxOFkh|ryP NWrVR4wyW0GQR1XS
KYSE-520 NGTReJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTR6LkWzNVUh|ryP MVjTRW5ITVJ?
SNG-M MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrCT5ZKSzVyPUS5MlQ{PCEQvF2= NYfyXI81W0GQR1XS
A2058 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLyWm9KSzVyPUS5MlQ5QDVizszN MljMV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 OSI-906 inhibits tumor growth in an IGF-1R-driven xenograft mouse model, with 100% TGI and 55% regression at a dose of 75 mg/kg and 60% TGI and no regression at a dose of 25 mg/kg. OSI-906 administration induces different elimination half-lives of itself in dog, rat and mice, the elimination half-lives are 1.18 hours, 2.64 hours and 2.14 hours, respectively. OSI-906 administration at different single dose once-daily in femal Sprague-Dawley rat and femal CD-1 mouse reveal that the Vmax is not dose-proportional to OSI-906 dose. OSI-906 elevates the blood glucose levels at a dose of 25 mg/kg after 12 days administration. OSI-906 administration at a single dose of 75 mg/kg in IGF-1R-driven full-length human IGF-1R (LISN) xenograft mouse model achieve maximal inhibition of IGF-1R phosphorylation (80%) between 4 and 24 hours with plasma drug concentrations of 26.6-4.77 μM. [1] OSI-906 administered as a single dose of at 60 mg/kg in NCI-H292 xenografts mice inhibits uptake of glucose at 2, 4, and 24 hours post-treatment in vivo. OSI-906 inhibits the growth of tumors in NCI-H292 xenograft mouse model. [2]
臨床試験 OSI-906 is currently under a Phase III clinical trial in adrenocortical carcinoma (ACC).
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Protein kinase biochemical assays Protein kinase assays are either performed in-house by ELISA-based assay methods (IGF-1R, IR, EGFR and KDR) or at Upstate Inc. by a radiometric method with ATP at 100 µM concentration. In-house ELISA assays use poly(Glu:Tyr) as the substrate bound to the surface of 96-well assay plates and phosphorylation is detected using an antiphosphotyrosine antibody conjugated to horseradish peroxidase. The bound antibody is quantified using ABTS as the peroxidase substrate by measuring absorbance at 405 / 490 nm. All assays use purified recombinant kinase catalytic domains. Recombinant enzymes of human IGF-1R or EGFR are expressed as an NH2-terminal glutathione S-transferase fusion protein in insect cells and are purified in house. IC50 values are determined from the sigmoidal dose–response plot of percent inhibition versus log10 compound concentration. A minimum of three measurements, performed in duplicate, are carried out with in-house assays unless otherwise indicated. OSI-906 at a concentration of 1 µM is profiled versus a panel of kinases using the ProfilerProTM Kinase Selectivity Assay Kit.

細胞アッセイ: [1]

細胞株 MCF7, NCI-H292, Colo-205, HT29, H358, H1703, BxPC3, A673, SW620, DU4475, HepG2 and Hepa-1, RKO 3T3/hulGF-IR and H292 cells
濃度 0.02-0.8 μM
反応時間 3 days
実験の流れ For assays of cell proliferation, cells are seeded into 96-well plates in appropriate media containing FCS 10% and incubated for 3 days in the presence of OSI-906 at various concentrations. Inhibition of cell growth is determined by luminescent quantitation of intracellular ATP content using CellTiterGlo. Data is presented as a fraction of maximal proliferation, calculated by dividing the cellular density in the presence of varying concentrations of OSI-906 by the cellular density of control cells treated with vehicle (DMSO) only.

動物実験: [1]

動物モデル IGF-1R-driven full-length human IGF-1R (LISN) xenograft mouse model
製剤 25 mM tartaric acid
投薬量 25 mg / kg and 75 mg / kg
投与方法 Orally administrated at once-daily oral dose for 14 days

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download OSI-906 (Linsitinib) SDF
分子量 421.49
化学式

C26H23N5O

CAS No. 867160-71-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 84 mg/mL (199.29 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 30mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol

文献中の引用 (15)

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related IGF-1R 阻害剤

  • Picropodophyllin (PPP)

    Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM. Phase 1/2.

  • Erlotinib

    Erlotinib is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.

  • R428 (BGB324)

    R428 (BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).

  • Pexidartinib (PLX3397)

    Pexidartinib (PLX3397) is an oral, potent mutil-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Phase 3.

  • BMS-536924

    BMS-536924は、ATP競争的IGF-IRとIR阻害剤で、IC50 がそれぞれ 100 nM と 73 nMです。

  • NVP-AEW541

    NVP-AEW541は、IGF-IRとInsRの二重阻害剤で、IC50 がそれぞれ 86 nM と 140 nMです。

  • NVP-ADW742

    NVP-ADW742は、0.17のμMのIC50によるIGF1R阻害剤です。

  • GSK1904529A

    GSK1904529Aは選択性阻害剤、(IGF-IR) と (IR)を抑制する時、 IC50が それぞれ27 nM と 25 nMになる.

  • BMS-754807

    BMS-754807は、IGF1R/IR家族キナーゼの強力で可逆的な阻害剤で、 IGF-1RIRMetTrkATrkBを妨げ、IC50 がそれぞれ 1.8 nM、1.7 nM、5.6 nM、7.4 nM 、 4.1 nMです。

    Features:Muti-inhibitor of the IGR-1R/IR family.

最近チェックしたアイテム

Tags: OSI-906 (Linsitinib)を買う | OSI-906 (Linsitinib)供給者 | OSI-906 (Linsitinib)を購入する | OSI-906 (Linsitinib)費用 | OSI-906 (Linsitinib)生産者 | オーダーOSI-906 (Linsitinib) | OSI-906 (Linsitinib)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ