OSI-906 (Linsitinib) 化学構造
分子量: 421.49

高品質保証

カスタマーフィードバック(3)

MSDS

製品説明

  • Compare IGF-1R Inhibitors
    IGF-1R製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 OSI-906(Linsitinib)は、IGF-IRとIrの選択的な阻害剤で、IC50 がそれぞれ 35 nM と 75 nMです。
ターゲット IGF-1R InsR
IC50 35 nM 75 nM [1]
In vitro試験 OSI-906 inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 μM. OSI-906 enables an intermediate conformation of the target protein through interactions with the C-helix. OSI-906 displays favorable metabolic stability in liver microsomes. OSI-906 fully inhibits both IR and IGF-1R phosphorylation at a concentration of 1 μM. OSI-906 inhibits proliferation of several tumor cell lines including non-small-cell lung cancer and colorectal cancer (CRC) tumor cell line with EC50 of 0.021 to 0.810 μM. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A4-Fuk MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fxNmlEPTB;MD6wNlgxPiEQvF2= NXX3e5lqW0GQR1XS
KS-1 M3zyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3VNoZYUUN3ME2wMlA{QDN3IN88US=> M3H2XnNCVkeHUh?=
TE-11 M2nP[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r3XGlEPTB;MD6wO|gzOiEQvF2= MnTtV2FPT0WU
EW-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOwUpg6UUN3ME2wMlA5PTh3IN88US=> M2nNWXNCVkeHUh?=
HMV-II MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEi4OFYh|ryP MUDTRW5ITVJ?
COLO-205 M{DBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvSWHl4UUN3ME2wMlExPDV2IN88US=> MUnTRW5ITVJ?
ES1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXYbWdKSzVyPUCuNVA3QTZizszN MkjJV2FPT0WU
GDM-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPJTWM2OD1yLkGzOlczKM7:TR?= MnWwV2FPT0WU
ML-2 NVTh[Y5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX1TWM2OD1yLkG1PFk3KM7:TR?= MnT4V2FPT0WU
Saos-2 NF;1V2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nKTWlEPTB;MD6xOlUzPiEQvF2= NYjZcXZuW0GQR1XS
NCI-H1355 NHvaZ3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLmTWM2OD1yLkG4NVM2KM7:TR?= M4ewWnNCVkeHUh?=
G-401 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzUTWM2OD1yLkG4NlMh|ryP NW\y[3FHW0GQR1XS
EW-16 M{PDRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXzPIVKSzVyPUCuNVg4PzdizszN NX7QR4tPW0GQR1XS
EW-7 NVPJdWJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMUi4PFEh|ryP MXvTRW5ITVJ?
NCI-H727 NWLkSoE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\HXGlEPTB;MD6xPVc6PCEQvF2= NYXUelZVW0GQR1XS
LCLC-97TM1 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPWZ3hjUUN3ME2wMlIxQTV3IN88US=> NInlUIJUSU6JRWK=
NCI-H650 NWf1ZoptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\k[WlEPTB;MD6yNVM5PCEQvF2= MU\TRW5ITVJ?
NCI-H2122 NVSxUFl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2e2VmlEPTB;MD6yN|I6QSEQvF2= Mn7OV2FPT0WU
SK-N-DZ M3j4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHTN5ZKSzVyPUCuNlM3QThizszN NYGzdZlxW0GQR1XS
HT-29 Ml;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLnNIhyUUN3ME2wMlI1OjR6IN88US=> NFe0N2VUSU6JRWK=
LB771-HNC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jlfGlEPTB;MD6yOVkyPSEQvF2= MnS0V2FPT0WU
HT-144 NFWz[FFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPBZ25KSzVyPUCuNlYyQTFizszN M3;Q[3NCVkeHUh?=
LAN-6 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rsfmlEPTB;MD6yOlM1QCEQvF2= NXq4UFAyW0GQR1XS
EW-18 MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXyTWM2OD1yLkK3NFAyKM7:TR?= M2TjWHNCVkeHUh?=
LS-1034 M2nWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTheGdyUUN3ME2wMlI4OTN{IN88US=> NXHXdI1uW0GQR1XS
EW-11 M3zrcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\ZU3NyUUN3ME2wMlI5PDN{IN88US=> M{WyZXNCVkeHUh?=
SNU-C1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTHPWdKSzVyPUCuNlk{OTNizszN NF[5PFFUSU6JRWK=
RS4-11 NWLIV|BOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjXcYNKSzVyPUCuN|M4PThizszN NGTGRotUSU6JRWK=
ES4 M2DpNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHGZpBKSzVyPUCuOFExOzhizszN MnjUV2FPT0WU
COLO-320-HSR NYX3dYpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfxbWtKSzVyPUCuOFE{PjhizszN NFnZTFVUSU6JRWK=
NB10 M1LRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvWTWM2OD1yLkS1OFM4KM7:TR?= NYLsWWhCW0GQR1XS
BFTC-905 NV:3VYZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3SOFhKSzVyPUCuOFY4PThizszN M2f5dnNCVkeHUh?=
A375 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwNEe2NVch|ryP M1LFZXNCVkeHUh?=
SJRH30 Ml3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwNUC4NlIh|ryP NXPDW2huW0GQR1XS
NOS-1 M2fwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PNcWlEPTB;MD61NlI3PyEQvF2= NFT4WJFUSU6JRWK=
SIG-M5 NXm2UXZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\mPWlEPTB;MD61N|U2PyEQvF2= MojhV2FPT0WU
DOK M3vQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwNUW2JO69VQ>? NWrj[|Z5W0GQR1XS
NB69 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzGN|dKSzVyPUCuOVgzPTdizszN MVTTRW5ITVJ?
SK-NEP-1 NFTUTWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwNkCyN|Yh|ryP MVjTRW5ITVJ?
SK-MM-2 NH7HVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrZfoZKSzVyPUCuOlU1QTFizszN Ml3mV2FPT0WU
NCI-H358 M4K1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\QTWM2OD1yLk[3NFgzKM7:TR?= M2LnTHNCVkeHUh?=
RH-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzXd5dKSzVyPUCuO|Q5PTlizszN MkLYV2FPT0WU
NH-12 NYm4R45RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS4TYdKSzVyPUCuO|YxPDZizszN NIPE[o1USU6JRWK=
TE-12 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:xdIF{UUN3ME2wMlc3PDh4IN88US=> NXfsdYN2W0GQR1XS
COLO-668 M{DZe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPQXGxKSzVyPUCuPFQ3PjZizszN MW\TRW5ITVJ?
PANC-08-13 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy5eXJNUUN3ME2wMlg3Ozd5IN88US=> M2XpXnNCVkeHUh?=
HCC2998 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf2TWM2OD1yLki4NlY{KM7:TR?= Mlz3V2FPT0WU
ABC-1 MmLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwOUCzOVIh|ryP NGrTNnlUSU6JRWK=
ES6 MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\HTGlEPTB;MD65NVA3PiEQvF2= MX\TRW5ITVJ?
SNU-387 M1\ve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPFdmRKSzVyPUCuPVk{QTNizszN M{jBc3NCVkeHUh?=
CMK Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwOUm5Nlkh|ryP MlPWV2FPT0WU
SJSA-1 MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHQU5FyUUN3ME2xMlA{PjV|IN88US=> MlviV2FPT0WU
SIMA NVTZbWFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFwME[4NlUh|ryP NVHoNGhQW0GQR1XS
ES3 NXrLcHZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnUeIpKSzVyPUGuNVIzQTdizszN MYXTRW5ITVJ?
IGROV-1 M4TS[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTUNVBqUUN3ME2xMlE2PDR2IN88US=> NFXSeGhUSU6JRWK=
MEL-JUSO NW\5UGZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPOOWZKSzVyPUGuNVU4PTlizszN M{XrOXNCVkeHUh?=
T84 M2ra[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWqzfI1rUUN3ME2xMlIxQTF2IN88US=> M4LwN3NCVkeHUh?=
CAL-85-1 M330eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfWe2llUUN3ME2xMlI{OTN6IN88US=> MYTTRW5ITVJ?
RD NX[4O4JIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTFwMk[0OVUh|ryP MY\TRW5ITVJ?
TE-8 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInDeFNKSzVyPUGuN|E1PjJizszN MoPyV2FPT0WU
L-363 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;sTWM2OD1zLkO0NlA5KM7:TR?= NUf4UYNYW0GQR1XS
EKVX NEfCelBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nLN2lEPTB;MT6zOFU3QCEQvF2= MYHTRW5ITVJ?
SK-MEL-3 NIDLR5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTFwNEi1OVYh|ryP M2HscHNCVkeHUh?=
TGBC24TKB NWHCVoV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfWSlBRUUN3ME2xMlUxOTl|IN88US=> MmrvV2FPT0WU
NCI-H1770 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3UR|BKSzVyPUGuOVEyOTNizszN NUnQepVjW0GQR1XS
HuH-7 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vDUGlEPTB;MT62NFA6QCEQvF2= MY\TRW5ITVJ?
HL-60 NFXORmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DXXWlEPTB;MT62OlkzQCEQvF2= Mlz4V2FPT0WU
TE-1 M4DjTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTFwN{C5OFUh|ryP MWHTRW5ITVJ?
LC-2-ad M1[yVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvjW|VKSzVyPUGuO|M5QDdizszN NFTUeJRUSU6JRWK=
LB647-SCLC MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvjTWM2OD1zLke2OVg{KM7:TR?= M1\tXnNCVkeHUh?=
NCI-H2171 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljYTWM2OD1zLke3O|E3KM7:TR?= MoHqV2FPT0WU
SK-PN-DW M3Lwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfYTWM2OD1zLkmxNlk5KM7:TR?= MoPrV2FPT0WU
MC-IXC M3nmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPSTWM2OD1zLkm4PVgh|ryP MW\TRW5ITVJ?
LS-513 M{Hpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJwMEWzNFUh|ryP M2nJN3NCVkeHUh?=
EW-3 NFLnNGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJwMEm4OFQh|ryP NWfXepZyW0GQR1XS
OPM-2 NFH0NGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XmW2lEPTB;Mj6xNFIh|ryP NFK1NIRUSU6JRWK=
LP-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJwMkW4NFch|ryP MYTTRW5ITVJ?
LU-134-A NYHocYNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\GelBKSzVyPUKuNlc4KM7:TR?= MkDkV2FPT0WU
CP66-MEL Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjsS|VKSzVyPUKuNlkxOTRizszN NWrSOGJxW0GQR1XS
HCC1143 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LqWmlEPTB;Mj60OVM3QCEQvF2= NH21UXNUSU6JRWK=
LOXIMVI Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\0b5NKSzVyPUKuOlAzOSEQvF2= M{K0UnNCVkeHUh?=
TE-10 MlXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwN{C4N|gh|ryP MVrTRW5ITVJ?
NCI-H1882 NV[4R|FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTJwN{WyNlch|ryP MX;TRW5ITVJ?
CHP-126 NUm4c4dCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPYZphKSzVyPUKuO|Y{OTdizszN MVrTRW5ITVJ?
NCI-H1623 NYfNOWIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrKW3FlUUN3ME2yMlkzODJ2IN88US=> NV3iU29CW0GQR1XS
GB-1 M1m5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTrSZFmUUN3ME2yMlk{PDB2IN88US=> Mn2zV2FPT0WU
RCC10RGB M{HhRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH4TWM2OD1{Lkm1NlgyKM7:TR?= Mm\OV2FPT0WU
NCI-H2141 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy2SnVJUUN3ME2yMlk3QDl4IN88US=> NX2xW|U4W0GQR1XS
GI-ME-N NULHSZFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7IV4tKSzVyPUOuNFA2PjVizszN NFThe4tUSU6JRWK=
NCI-H526 NEn0To5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[0SGlEPTB;Mz6wOFA5PSEQvF2= MX\TRW5ITVJ?
NCI-H747 Ml3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPpUphKSzVyPUOuNFQ6QTJizszN NIrmZ3NUSU6JRWK=
SNU-423 Mny0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPjTJZ1UUN3ME2zMlIxOzF|IN88US=> NF;n[5VUSU6JRWK=
A427 NYr0UFBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrLemJkUUN3ME2zMlI2Pjl7IN88US=> MnfIV2FPT0WU
CAL-12T NXLOcnpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEm2RYdKSzVyPUOuOFA4OTNizszN NVyyWGVMW0GQR1XS
LU-99A NWnRbYw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[xcWlEPTB;Mz60O|ExPSEQvF2= MlGzV2FPT0WU
MS-1 NU\sdFk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXScWZKSzVyPUOuOVM1OjlizszN MVPTRW5ITVJ?
SK-LU-1 NWHI[GlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkWzTWM2OD1|Lke2Nlk2KM7:TR?= MXrTRW5ITVJ?
SW837 NWnuWIpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWK1[Il6UUN3ME2zMlc3OzN|IN88US=> NWPvR5IxW0GQR1XS
ES8 Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTNwOEO4O|ch|ryP NIXYdmxUSU6JRWK=
MZ2-MEL NHO2cJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXGb2EyUUN3ME2zMlkzODh4IN88US=> MWjTRW5ITVJ?
TGW NXvCVGpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTKdXZKSzVyPUSuNFE{OTFizszN M1TReHNCVkeHUh?=
GP5d NUfqRldtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NISycVZKSzVyPUSuNFU{PjJizszN NHi2fY1USU6JRWK=
BB49-HNC M{TUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn1TWM2OD12LkG1NlE{KM7:TR?= NIHsSGRUSU6JRWK=
NB13 MmTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTRwMk[4PFch|ryP M1XaPXNCVkeHUh?=
NTERA-S-cl-D1 M4PhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVywWolLUUN3ME20MlI5PjF3IN88US=> MYTTRW5ITVJ?
NCI-H1648 MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTRwMkm4NVkh|ryP M{\XO3NCVkeHUh?=
LCLC-103H MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDqTWM2OD12LkOyNVk2KM7:TR?= NEDMZWlUSU6JRWK=
LS-411N MoC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTRwNES4PFUh|ryP Ml20V2FPT0WU
NCI-H1092 NIeyW3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTRwNEW2PFch|ryP MlHNV2FPT0WU
PANC-10-05 NH\OSWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDTTWM2OD12Lk[5PFQh|ryP MVTTRW5ITVJ?
DK-MG MmHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zGO2lEPTB;ND64NFk{OyEQvF2= Mn24V2FPT0WU
OVCAR-5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi2TWM2OD12LkixNlI3KM7:TR?= M2j5ZnNCVkeHUh?=
CAL-39 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7wTWM2OD12Lki3Olch|ryP M1G5ZnNCVkeHUh?=
TE-441-T NGfjfY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\JeFRKSzVyPUSuPVA2OzdizszN NUn6fII4W0GQR1XS
MOLT-16 MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofyTWM2OD12Lkm1NlU{KM7:TR?= M2Lod3NCVkeHUh?=
MCF7 NXnvdGpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zwO2lEPTB;NT6xOFUyPyEQvF2= NGC0SFBUSU6JRWK=
CAPAN-1 NF;Z[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jN[GlEPTB;NT6yOVcxPyEQvF2= MVjTRW5ITVJ?
PSN1 NUjsfXBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\COFNMUUN3ME21MlI4OjN3IN88US=> MVHTRW5ITVJ?
NCI-H292 NFPSZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DZfGlEPTB;NT6zNFA1PCEQvF2= MmLXV2FPT0WU
CPC-N NI\ENFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XOTGlEPTB;NT6zPVQyQSEQvF2= NW\EZndVW0GQR1XS
DoTc2-4510 NG[zUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M333fmlEPTB;NT60OVM4OSEQvF2= NXnCOpdlW0GQR1XS
LB1047-RCC NEjsZYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrjZ5pKSzVyPUWuOVU6OzNizszN M1jRWnNCVkeHUh?=
MHH-ES-1 M2\tU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPqWItKSzVyPUWuOVk6ODdizszN NFTCRWRUSU6JRWK=
NMC-G1 M2rYdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjqOYpKSzVyPUWuO|AzOjdizszN NXvF[mMyW0GQR1XS
SW1710 M1jlXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHkXYhKSzVyPUWuO|Q4PTFizszN MVPTRW5ITVJ?
YAPC MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[yW2lEPTB;NT63OlIxOSEQvF2= MXTTRW5ITVJ?
22RV1 NIH5XHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTVwOECwNVkh|ryP NHH0RolUSU6JRWK=
COLO-679 NInHflNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T5RWlEPTB;NT64PFk1QCEQvF2= NF7mNVVUSU6JRWK=
TCCSUP M{PZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\nOVRsUUN3ME21Mlk{OjV7IN88US=> Ml20V2FPT0WU
C2BBe1 NEnCU3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MomyTWM2OD13LkmzPVch|ryP Mke3V2FPT0WU
TE-15 MoLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm5[pFKSzVyPU[uNFY3ODVizszN MWjTRW5ITVJ?
SCLC-21H NUXpNnNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTP[Gg6UUN3ME22MlExQDR|IN88US=> M4rDRXNCVkeHUh?=
EoL-1-cell NGHGbmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fx[GlEPTB;Nj6xOlU3OyEQvF2= NEjEeGJUSU6JRWK=
NKM-1 Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDDcndbUUN3ME22MlE3PzFizszN NGnzc5pUSU6JRWK=
NCI-H1304 MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnHdoM3UUN3ME22MlI4PDJ6IN88US=> M1Tib3NCVkeHUh?=
NB6 M3vwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIX3VW5KSzVyPU[uNlk3OjJizszN NFXGT3JUSU6JRWK=
NALM-6 NXr1emZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4G3PGlEPTB;Nj6zN|I{KM7:TR?= NGG4dXJUSU6JRWK=
NCI-H522 NWD4OFJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTZwM{OzNFYh|ryP M3fFOHNCVkeHUh?=
MV-4-11 NWfKcHJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13pTWlEPTB;Nj6zO|A4QSEQvF2= M17IVnNCVkeHUh?=
LB2241-RCC M4DLW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\tTGlEPTB;Nj6zPFY3PyEQvF2= NXPZUINxW0GQR1XS
NCI-H1417 MkHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULXPGFNUUN3ME22MlQxQDR5IN88US=> NWH5bYQ2W0GQR1XS
HT-1197 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTZwNUexNlIh|ryP MXvTRW5ITVJ?
P30-OHK MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\zNXdrUUN3ME22MlYzPzdizszN M{jxN3NCVkeHUh?=
ALL-PO M{fBZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHVTWM2OD14LkexPVE3KM7:TR?= MWfTRW5ITVJ?
OVCAR-4 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfmfGlKSzVyPU[uO|U1ODVizszN NUTXW21xW0GQR1XS
HCC2157 M2W0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHDb5FKSzVyPU[uO|c1PzVizszN MmTiV2FPT0WU
NCI-H838 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlixTWM2OD14Lkm2OFkh|ryP NF\UXopUSU6JRWK=
NCI-H1299 NF62[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fuRWlEPTB;Nj65O|A6KM7:TR?= MnrrV2FPT0WU
SW954 MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTdwMkCwOlgh|ryP NYPTXFhPW0GQR1XS
NCI-H441 M3PxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTdwM{SwOlUh|ryP MnrDV2FPT0WU
SK-MEL-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LZfWlEPTB;Nz60PFM4OyEQvF2= NWfrSIxQW0GQR1XS
KARPAS-45 NES2SXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\3TWM2OD15Lk[1PVI6KM7:TR?= M{XDdnNCVkeHUh?=
CAL-54 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXmSohVUUN3ME23MlgzQTd5IN88US=> MV3TRW5ITVJ?
KYSE-180 M17MXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPyT3pRUUN3ME23Mlg5QTRzIN88US=> MXPTRW5ITVJ?
NCI-H187 NEHRbYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrTR|JtUUN3ME23Mlk2QTR5IN88US=> NEPZe3FUSU6JRWK=
RT-112 NUnhc4JXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDOZW1ZUUN3ME24MlA6Pjd5IN88US=> NV65VGFJW0GQR1XS
NCI-H1437 MkntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K0dGlEPTB;OD6wPVc6PSEQvF2= NF3vOolUSU6JRWK=
SNU-449 M4nVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HDcWlEPTB;OD6yPFI4OiEQvF2= NULlSlViW0GQR1XS
HCC1187 Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfic5lKSzVyPUiuNlk{QTFizszN NVTLeXZJW0GQR1XS
NCI-H2030 M1HxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHGeINKSzVyPUiuN|c4OTRizszN M2\rbnNCVkeHUh?=
HuO-3N1 M1XpWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRThwM{e4OFQh|ryP MnvyV2FPT0WU
COLO-792 M1PFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGi2d5FKSzVyPUiuOFE2OjdizszN MY\TRW5ITVJ?
MIA-PaCa-2 NWHqfIo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRThwOEW1NFgh|ryP NIXUe4VUSU6JRWK=
SK-N-FI NEnhOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH1TWM2OD17LkC0NlUh|ryP NVzETmRTW0GQR1XS
MMAC-SF MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTlwMEm3OVEh|ryP MlLyV2FPT0WU
NCI-H28 NE[wVXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\wTWM2OD17LkGwOFY6KM7:TR?= MnTNV2FPT0WU
ETK-1 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\UO2lEPTB;OT6yPVk4PCEQvF2= M2PzSHNCVkeHUh?=
NCI-H1993 NVzmOnU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrkbGdkUUN3ME25MlQ1OjZzIN88US=> Mo[zV2FPT0WU
no-11 M4LRVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorUTWM2OD17LkS3NVIh|ryP NXfEZ4FqW0GQR1XS
ChaGo-K-1 NXjMd3o3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTDTZpOUUN3ME25MlUyPTh|IN88US=> NGDIXpBUSU6JRWK=
NCCIT NVTGeIRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXLNoVQUUN3ME25MlU{OTZ7IN88US=> MXnTRW5ITVJ?
SAS NWDtOYJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFyLkK0PEDPxE1? M{\0fHNCVkeHUh?=
A673 NH\hO2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S3TWlEPTB;MUCuN|cxPCEQvF2= MWfTRW5ITVJ?
NCI-H1522 Ml7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fSOGlEPTB;MUCuN|cxPyEQvF2= M3yzXXNCVkeHUh?=
NCI-H810 MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXMS3diUUN3ME2xNE4{QTB5IN88US=> MYrTRW5ITVJ?
IST-MES1 M3;5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPL[oR3UUN3ME2xNE41PTZ2IN88US=> NEnVSGhUSU6JRWK=
GR-ST MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PObmlEPTB;MUCuOVAzPCEQvF2= M2ewZnNCVkeHUh?=
SUP-T1 M2myWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3NfGhIUUN3ME2xNE44OzF5IN88US=> MmrLV2FPT0WU
NB5 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mom5TWM2OD1zMD65NFIzKM7:TR?= NYjCcHZoW0GQR1XS
MZ1-PC NXrJSmFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG4OnVmUUN3ME2xNE46PTdzIN88US=> NHzWPHNUSU6JRWK=
SK-CO-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r6TWlEPTB;MUCuPVk{OSEQvF2= NVXVbm5zW0GQR1XS
Capan-2 M16wRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13yfmlEPTB;MUGuN|E6QCEQvF2= MUDTRW5ITVJ?
697 MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFzLk[3OVch|ryP MnzsV2FPT0WU
REH MkHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf4TWM2OD1zMT63OFUyKM7:TR?= MVXTRW5ITVJ?
GI-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzmR3VKSzVyPUGxMlg3OTVizszN MlqxV2FPT0WU
BB65-RCC NEfTe2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX6V3ZKSzVyPUGyMlA6OTZizszN MnGzV2FPT0WU
NCI-H1651 NULrfpNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX5dnVKSzVyPUGyMlI1PzhizszN NYT5OHU6W0GQR1XS
NCI-H1618 NEHvd|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXXZY5KSzVyPUGyMlM6PzZizszN M3vkNXNCVkeHUh?=
NCI-H2081 MkPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;EbJI5UUN3ME2xNk43OTRzIN88US=> MUHTRW5ITVJ?
GCIY NWHEW4JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILFU|JKSzVyPUGyMlczOTNizszN NEDhTFZUSU6JRWK=
NY NFO1SYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPjVVl2UUN3ME2xN{4xPjR|IN88US=> Mo\3V2FPT0WU
PANC-03-27 NYDYV|BHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr0Z3JKSzVyPUGzMlA5ODdizszN NGjKe2ZUSU6JRWK=
BHY M1T3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLiTWM2OD1zMz6yNVIyKM7:TR?= Mn;5V2FPT0WU
SK-OV-3 NH7hdZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW5TWM2OD1zMz6zO|Y{KM7:TR?= MXXTRW5ITVJ?
5637 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHW[2VKSzVyPUGzMlc4PTlizszN MWjTRW5ITVJ?
LC-1F NUOzeIRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrzWIhkUUN3ME2xOE4xOzV4IN88US=> MU\TRW5ITVJ?
SNB75 NGjxO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF2LkCzPFMh|ryP MlLqV2FPT0WU
CHP-212 M{PUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;VTWM2OD1zND6wOFY1KM7:TR?= NVvvRZFDW0GQR1XS
HT-1376 M37SZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnEVZJWUUN3ME2xOE4yOTJ4IN88US=> NEnFR|NUSU6JRWK=
MONO-MAC-6 NFXwdIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX2TY5KSzVyPUG0MlE2ODJizszN MnXUV2FPT0WU
CA46 NWeyZpdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfwWWxKSzVyPUG0MlE5OjdizszN NYjSfYZMW0GQR1XS
SCC-15 M325dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnrfHQ1UUN3ME2xOE42PTh|IN88US=> NV\vUmFNW0GQR1XS
ATN-1 NV;hPZFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPJfGI{UUN3ME2xOE43PjJ5IN88US=> Mmi1V2FPT0WU
NCI-H2405 NIL4NGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfkTVhSUUN3ME2xOE45OTV5IN88US=> MYfTRW5ITVJ?
NCI-H716 NHy5RWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nLNWlEPTB;MUSuPFQ6OyEQvF2= NGPm[Y1USU6JRWK=
SW620 MnL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTF2LkmwNVQh|ryP NIjCenlUSU6JRWK=
NCI-H226 NYjINXlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzBTWM2OD1zND65NFg2KM7:TR?= M{fCXXNCVkeHUh?=
SW962 NHezSW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTqTWM2OD1zND65OFMzKM7:TR?= NHLQWlBUSU6JRWK=
KYSE-150 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HLWWlEPTB;MUSuPVU2KM7:TR?= Ml;EV2FPT0WU
OCUB-M MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W3U2lEPTB;MUSuPVg5OyEQvF2= M{fEOHNCVkeHUh?=
ES7 NFqyTpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofjTWM2OD1zNT6wPVg1KM7:TR?= NFWwUJJUSU6JRWK=
SW1463 NV\X[5ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\xV4hxUUN3ME2xOU41OjJ|IN88US=> MYLTRW5ITVJ?
CAKI-1 NXftb2RIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnOTWM2OD1zNT61N|Q3KM7:TR?= MVvTRW5ITVJ?
MKN28 NITCVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn3[VZKSzVyPUG1MlU1PzlizszN NHPJNJFUSU6JRWK=
SW13 NUi4PW13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X5bmlEPTB;MUWuOlE5KM7:TR?= NWS1cZVmW0GQR1XS
A3-KAW MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXFepJ{UUN3ME2xOU46Pjl5IN88US=> NG\VRmNUSU6JRWK=
LU-65 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfuVlZKSzVyPUG1Mlk4PjhizszN NEO0SVlUSU6JRWK=
Calu-1 NEW4[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLtTWM2OD1zNj6wN|Y5KM7:TR?= M2nHT3NCVkeHUh?=
ST486 NX[w[3lVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTF4LkC0N|Eh|ryP M{TPe3NCVkeHUh?=
BB30-HNC NV74b3c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3O0R2lEPTB;MU[uNVI1PiEQvF2= NVvmWFNVW0GQR1XS
EGI-1 NIj3[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLlb28xUUN3ME2xOk41PDZizszN NWjvbZRjW0GQR1XS
SH-4 Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTF4LkS3N|Eh|ryP Moe4V2FPT0WU
MN-60 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTF5LkKyPVch|ryP MkOwV2FPT0WU
MPP-89 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF5LkK0OVkh|ryP M2TkXXNCVkeHUh?=
A2780 M{X3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrLO3BHUUN3ME2xO{41OTN7IN88US=> MoDZV2FPT0WU
Daoy NVHiZ4FUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHDTWM2OD1zNz60Olk2KM7:TR?= MYjTRW5ITVJ?
NCI-H2126 NIHSXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF5LkS3O|Eh|ryP Mn\hV2FPT0WU
NCI-H1563 NYD6OJpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTF5LkS5NVch|ryP NH6yWIZUSU6JRWK=
8-MG-BA NVe5dZJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrySmdKSzVyPUG3MlY3PDhizszN NGHOcIlUSU6JRWK=
786-0 M{H2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TjbGlEPTB;MUeuPFM2OyEQvF2= M2fpbXNCVkeHUh?=
AM-38 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVroNYd1UUN3ME2xO{46OzB4IN88US=> MojSV2FPT0WU
COLO-824 NI[2dWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTF6LkS0N|Yh|ryP NYfXW29tW0GQR1XS
SK-MEL-30 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPDeog{UUN3ME2xPE42ODh{IN88US=> NWTLO|ZDW0GQR1XS
CESS NH6zPYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[1b2lEPTB;MUiuO|YxQSEQvF2= M3HNOHNCVkeHUh?=
BL-70 M2PtOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfQd2MxUUN3ME2xPE45OTV4IN88US=> MnGzV2FPT0WU
NCI-H2170 NYLUdJd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\Jc2lEPTB;MUiuPVE4QSEQvF2= M3;uRnNCVkeHUh?=
HT-3 NIPNRZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfFTWM2OD1zOD65PFMh|ryP M2DqNXNCVkeHUh?=
BOKU MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTF7LkCzPFEh|ryP M2SySnNCVkeHUh?=
HPAF-II Mnr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofxTWM2OD1zOT6zNFE2KM7:TR?= MXPTRW5ITVJ?
KGN MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;VWJlKSzVyPUG5MlQ4PjVizszN NH\tV2JUSU6JRWK=
MC-CAR MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYqwVmp5UUN3ME2xPU43OzF|IN88US=> M4KwWXNCVkeHUh?=
BHT-101 NWPyUnUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfaSY5KSzVyPUG5Mlc4PyEQvF2= NYnsVIZZW0GQR1XS
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... Click to View More Cell Line Experimental Data

In vivo試験 OSI-906 inhibits tumor growth in an IGF-1R-driven xenograft mouse model, with 100% TGI and 55% regression at a dose of 75 mg/kg and 60% TGI and no regression at a dose of 25 mg/kg. OSI-906 administration induces different elimination half-lives of itself in dog, rat and mice, the elimination half-lives are 1.18 hours, 2.64 hours and 2.14 hours, respectively. OSI-906 administration at different single dose once-daily in femal Sprague-Dawley rat and femal CD-1 mouse reveal that the Vmax is not dose-proportional to OSI-906 dose. OSI-906 elevates the blood glucose levels at a dose of 25 mg/kg after 12 days administration. OSI-906 administration at a single dose of 75 mg/kg in IGF-1R-driven full-length human IGF-1R (LISN) xenograft mouse model achieve maximal inhibition of IGF-1R phosphorylation (80%) between 4 and 24 hours with plasma drug concentrations of 26.6-4.77 μM. [1] OSI-906 administered as a single dose of at 60 mg/kg in NCI-H292 xenografts mice inhibits uptake of glucose at 2, 4, and 24 hours post-treatment in vivo. OSI-906 inhibits the growth of tumors in NCI-H292 xenograft mouse model. [2]
臨床試験 OSI-906 is currently under a Phase III clinical trial in adrenocortical carcinoma (ACC).
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Protein kinase biochemical assays Protein kinase assays are either performed in-house by ELISA-based assay methods (IGF-1R, IR, EGFR and KDR) or at Upstate Inc. by a radiometric method with ATP at 100 µM concentration. In-house ELISA assays use poly(Glu:Tyr) as the substrate bound to the surface of 96-well assay plates and phosphorylation is detected using an antiphosphotyrosine antibody conjugated to horseradish peroxidase. The bound antibody is quantified using ABTS as the peroxidase substrate by measuring absorbance at 405 / 490 nm. All assays use purified recombinant kinase catalytic domains. Recombinant enzymes of human IGF-1R or EGFR are expressed as an NH2-terminal glutathione S-transferase fusion protein in insect cells and are purified in house. IC50 values are determined from the sigmoidal dose–response plot of percent inhibition versus log10 compound concentration. A minimum of three measurements, performed in duplicate, are carried out with in-house assays unless otherwise indicated. OSI-906 at a concentration of 1 µM is profiled versus a panel of kinases using the ProfilerProTM Kinase Selectivity Assay Kit.

細胞アッセイ: [1]

細胞株 MCF7, NCI-H292, Colo-205, HT29, H358, H1703, BxPC3, A673, SW620, DU4475, HepG2 and Hepa-1, RKO 3T3/hulGF-IR and H292 cells
濃度 0.02-0.8 μM
反応時間 3 days
実験の流れ For assays of cell proliferation, cells are seeded into 96-well plates in appropriate media containing FCS 10% and incubated for 3 days in the presence of OSI-906 at various concentrations. Inhibition of cell growth is determined by luminescent quantitation of intracellular ATP content using CellTiterGlo. Data is presented as a fraction of maximal proliferation, calculated by dividing the cellular density in the presence of varying concentrations of OSI-906 by the cellular density of control cells treated with vehicle (DMSO) only.

動物実験: [1]

動物モデル IGF-1R-driven full-length human IGF-1R (LISN) xenograft mouse model
製剤 25 mM tartaric acid
投薬量 25 mg / kg and 75 mg / kg
投与方法 Orally administrated at once-daily oral dose for 14 days

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download OSI-906 (Linsitinib) SDF
分子量 421.49
化学式

C26H23N5O

CAS No. 867160-71-2
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 84 mg/mL (199.29 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 30mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol

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Frequently Asked Questions

  • Question 1
    Does the inhibitor dissolve in the vehicle (30% PEG400/0.5%Tween 80/5% propylene glycol) or is it a suspension?

    Answer: OSI-906 in 30% PEG400/0.5%Tween 80/5% propylene glycol is a suspension.

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Tags: OSI-906 (Linsitinib)を買う | OSI-906 (Linsitinib)供給者 | OSI-906 (Linsitinib)を購入する | OSI-906 (Linsitinib)費用 | OSI-906 (Linsitinib)生産者 | オーダーOSI-906 (Linsitinib) | OSI-906 (Linsitinib)代理店
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