Luminespib (AUY-922, NVP-AUY922) 化学構造
分子量: 465.54

高品質保証

カスタマーフィードバック(3)

Quality Control & MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野
  • Luminespib (AUY-922, NVP-AUY922)のメカニズム

製品の説明

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。
ターゲット HSP90α HSP90β
IC50 13 nM 21 nM [1]
In vitro試験 NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMK NXnWclV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzKfHRKSzVyPUCuNFAxOTJ3IN88US=> MoXkV2FPT0WU
MV-4-11 NYHKUJFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjwSpdKUUN3ME2wMlAxODV3ODFOwG0> M1z1dHNCVkeHUh?=
NALM-6 NXnEWFIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnLWJRNUUN3ME2wMlAxODh2MjFOwG0> M1zlT3NCVkeHUh?=
HOS M4D1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH4TWM2OD1yLkCwNVM5KM7:TR?= M3zBcXNCVkeHUh?=
HT-144 MnjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMECxOVUh|ryP MnvNV2FPT0WU
SW1710 MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\u[IQ5UUN3ME2wMlAxOTh4IN88US=> M{TqTnNCVkeHUh?=
TE-8 NHnJW5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe4eG5kUUN3ME2wMlAxOjN5IN88US=> NFjxOGdUSU6JRWK=
ES1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMECyOlYh|ryP Moq0V2FPT0WU
CCF-STTG1 NX3yem41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEiyUlhKSzVyPUCuNFAzQTdizszN NFz3WGJUSU6JRWK=
PSN1 Mmr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrYc5M2UUN3ME2wMlAxOzF6IN88US=> NGjEd|lUSU6JRWK=
CAL-51 NE\oXHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2G5dmlEPTB;MD6wNFMzPSEQvF2= NEL4eHdUSU6JRWK=
MCF7 MljNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[yTWM2OD1yLkCwN|M2KM7:TR?= NGXTNY5USU6JRWK=
SK-HEP-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMECzN|Yh|ryP NVvndmFUW0GQR1XS
LCLC-103H M4XYPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW1[IpHUUN3ME2wMlAxPDNizszN M1;ZPHNCVkeHUh?=
HMV-II NXv5cmhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnSTWM2OD1yLkCwOFQ6KM7:TR?= NVTldI43W0GQR1XS
MES-SA MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4exZWlEPTB;MD6wNFQ2OiEQvF2= M36wU3NCVkeHUh?=
SK-LMS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;ic|J[UUN3ME2wMlAxPDV6IN88US=> M3vWUnNCVkeHUh?=
639-V NET1d|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfFW4lKSzVyPUCuNFA1QDVizszN MoHxV2FPT0WU
SIG-M5 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXH2O3d6UUN3ME2wMlAxPDh7IN88US=> M2q2b3NCVkeHUh?=
LOUCY NHfKO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13nVmlEPTB;MD6wNFUxPSEQvF2= MorzV2FPT0WU
HSC-2 NWP2ZXJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLoPHBVUUN3ME2wMlAxPTF6IN88US=> MVzTRW5ITVJ?
EW-13 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPhTWM2OD1yLkCwOVE5KM7:TR?= NHPTco5USU6JRWK=
RT-112 MoruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEC1N|Uh|ryP NXTF[XZuW0GQR1XS
NKM-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjSTWM2OD1yLkCwOVQ4KM7:TR?= MkXvV2FPT0WU
KYSE-180 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEC1PFYh|ryP MUfTRW5ITVJ?
SW1783 M3\BTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jKdGlEPTB;MD6wNFU6OSEQvF2= M1:2XnNCVkeHUh?=
A431 NXzRe4lxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3sTWM2OD1yLkCwOlA4KM7:TR?= Mnm4V2FPT0WU
SK-OV-3 NGr4eFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\NRnk5UUN3ME2wMlAxPjNizszN NFnLbpBUSU6JRWK=
RPMI-7951 NV3ObGI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXOxW4M6UUN3ME2wMlAxPjNzIN88US=> NGHrcodUSU6JRWK=
Capan-2 M4e3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEC2N|gh|ryP M3nHe3NCVkeHUh?=
HSC-3 M3;3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq5d3FOUUN3ME2wMlAxPjRzIN88US=> M{LjcnNCVkeHUh?=
786-0 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn75TWM2OD1yLkCwOlY{KM7:TR?= NYDPZ49zW0GQR1XS
Daoy MknBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H4Z2lEPTB;MD6wNFY6PSEQvF2= M3LQRnNCVkeHUh?=
KGN NIXzd5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEC3NFMh|ryP MXLTRW5ITVJ?
EW-16 NWXWOoRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL4XlZKSzVyPUCuNFA4PDlizszN MnvHV2FPT0WU
EW-7 M3ruOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\lTWM2OD1yLkCwO|U1KM7:TR?= NFKycFhUSU6JRWK=
IGROV-1 NHjzO4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M120UGlEPTB;MD6wNFgyPCEQvF2= NFrPcYhUSU6JRWK=
8505C M2jzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3raNmlEPTB;MD6wNFgzOSEQvF2= MnfUV2FPT0WU
RKO Mn7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnD[|NDUUN3ME2wMlAxQDJ4IN88US=> MnTjV2FPT0WU
GDM-1 NFO2do1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEGzb3hKSzVyPUCuNFA5PCEQvF2= NET3b2ZUSU6JRWK=
IST-MEL1 MnnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PpTWlEPTB;MD6wNFg2OiEQvF2= MXTTRW5ITVJ?
RPMI-6666 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rOPGlEPTB;MD6wNFg2OiEQvF2= NVPpb2JFW0GQR1XS
SNG-M MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHHeW5KSzVyPUCuNFA5PTZizszN MVnTRW5ITVJ?
KS-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXPO5dKSzVyPUCuNFA5PTlizszN NUDLb2ROW0GQR1XS
RXF393 NYXJeFI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml63TWM2OD1yLkCwPFYh|ryP NUXXTm56W0GQR1XS
CAL-12T NGC4R4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[2bGlEPTB;MD6wNFkzOiEQvF2= NVuxVVNpW0GQR1XS
BFTC-905 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEC5N|gh|ryP MlXCV2FPT0WU
SK-MES-1 NHzSOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnk[|lKSzVyPUCuNFA6PDVizszN MWnTRW5ITVJ?
BB30-HNC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEC5OVIh|ryP MmrvV2FPT0WU
AN3-CA NUC4NmJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUO0V3h2UUN3ME2wMlAyODF5IN88US=> MnLTV2FPT0WU
EFO-27 NV[wbXBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPBd2RsUUN3ME2wMlAyODF5IN88US=> MmPuV2FPT0WU
G-401 MofhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXabJd4UUN3ME2wMlAyODJ3IN88US=> M{H4TnNCVkeHUh?=
BPH-1 Ml7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\ofo1tUUN3ME2wMlAyODNizszN NFT3SHFUSU6JRWK=
NCI-H727 MlnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnqb3ZKSzVyPUCuNFExOyEQvF2= M1jmR3NCVkeHUh?=
SNU-423 MoL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;kW2lEPTB;MD6wNVA2OyEQvF2= MX3TRW5ITVJ?
KYSE-270 NIraNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W4d2lEPTB;MD6wNVA2QSEQvF2= NW[zXJh{W0GQR1XS
AGS NXvIe5NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:3W4ZuUUN3ME2wMlAyODZzIN88US=> NVHMV|BZW0GQR1XS
NCI-H2228 NHzjbI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf0WlJlUUN3ME2wMlAyODZ2IN88US=> M4HncnNCVkeHUh?=
SW954 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzmZmNKSzVyPUCuNFExPzFizszN MkLuV2FPT0WU
769-P NYP0TXV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HFOWlEPTB;MD6wNVA4OyEQvF2= MkXMV2FPT0WU
BB49-HNC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEGwO|ch|ryP Mmf0V2FPT0WU
IA-LM NGnLUJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m0bWlEPTB;MD6wNVA5PiEQvF2= NUO5[GdkW0GQR1XS
NB69 M{\odWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17jWWlEPTB;MD6wNVExOiEQvF2= M3fyNHNCVkeHUh?=
C8166 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jBXGlEPTB;MD6wNVEzQSEQvF2= MkmwV2FPT0WU
NCI-H1299 M2LUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HIdWlEPTB;MD6wNVE2PCEQvF2= M2\4XnNCVkeHUh?=
YKG-1 NGn4XWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;yWGlEPTB;MD6wNVE3KM7:TR?= NWLKPY54W0GQR1XS
PANC-03-27 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2K1WmlEPTB;MD6wNVE3OiEQvF2= MYjTRW5ITVJ?
YT NH\nNHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP1bZZKSzVyPUCuNFEyPzlizszN MXfTRW5ITVJ?
CAL-85-1 NFX6fIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XtZ2lEPTB;MD6wNVE6OiEQvF2= MXnTRW5ITVJ?
GT3TKB Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C5XmlEPTB;MD6wNVIxOiEQvF2= NICybWdUSU6JRWK=
BB65-RCC MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDaTWM2OD1yLkCxNlA1KM7:TR?= MVnTRW5ITVJ?
ES6 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLxTWM2OD1yLkCxNlYyKM7:TR?= NFrMcoNUSU6JRWK=
MHH-ES-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGxTWM2OD1yLkCxNlY{KM7:TR?= MYjTRW5ITVJ?
QIMR-WIL NHPyN2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PxVmlEPTB;MD6wNVI3QSEQvF2= M1TRW3NCVkeHUh?=
SNU-C2B NW[wSFNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEGyO|Ih|ryP M{DpXHNCVkeHUh?=
OCI-AML2 NInzTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfOeolKSzVyPUCuNFEzQDFizszN MYrTRW5ITVJ?
DU-145 NGDxTWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[1bWlEPTB;MD6wNVI6KM7:TR?= MnHZV2FPT0WU
SW982 M{OwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\ETlBKSzVyPUCuNFEzQTNizszN M4Dtd3NCVkeHUh?=
MFH-ino MkjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjqTWM2OD1yLkCxNlk{KM7:TR?= NI\j[2hUSU6JRWK=
A427 MnfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnJWYxKSzVyPUCuNFEzQTlizszN MoWzV2FPT0WU
LCLC-97TM1 NGP1WG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL6TFBKSzVyPUCuNFE{KM7:TR?= M1z1Z3NCVkeHUh?=
AM-38 MlfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rnV2lEPTB;MD6wNVMxOiEQvF2= NIjrWW9USU6JRWK=
K5 M{jIcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7LTJd2UUN3ME2wMlAyOzB6IN88US=> M33PN3NCVkeHUh?=
T84 NW\sTFBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7YPGVKSzVyPUCuNFE{OzFizszN NH30cXVUSU6JRWK=
TE-15 M2n6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj5TWM2OD1yLkCxN|M3KM7:TR?= NYTPXYd4W0GQR1XS
NCI-H460 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPaZ3JKSzVyPUCuNFE{OzZizszN NVzYTY05W0GQR1XS
NTERA-S-cl-D1 NXzqV5E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmzTWM2OD1yLkCxN|M6KM7:TR?= NGTMVFRUSU6JRWK=
KYSE-450 NHz4Vm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEGzOFkh|ryP MnHnV2FPT0WU
H4 NFXhUYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEGzOlYh|ryP M{XmPXNCVkeHUh?=
LC-2-ad NIH1cWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEGzO{DPxE1? NV;CZopsW0GQR1XS
GAMG NIn4fVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXJdlNIUUN3ME2wMlAyOzdzIN88US=> M3fOe3NCVkeHUh?=
TK10 NGnBclNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17rdGlEPTB;MD6wNVM5OiEQvF2= NWrsRo1sW0GQR1XS
NCI-H2122 Moj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\URWdKSzVyPUCuNFE{QDRizszN NV\KTJQ6W0GQR1XS
KM12 NHnadmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEGzPVkh|ryP M3zyXnNCVkeHUh?=
CAL-39 NWC4SZZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfYc|k6UUN3ME2wMlAyPDJizszN MlTiV2FPT0WU
RPMI-2650 Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTZTWM2OD1yLkCxOFMzKM7:TR?= NXLxS|F2W0GQR1XS
KYSE-510 NFHSZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nKSWlEPTB;MD6wNVQ1OiEQvF2= NEHvXohUSU6JRWK=
KALS-1 NXzRRW9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LtRWlEPTB;MD6wNVQ3PiEQvF2= MYHTRW5ITVJ?
NCI-H1648 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\pTWM2OD1yLkCxOFk6KM7:TR?= NH7pbYdUSU6JRWK=
ES4 NWr6NGRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnMO2xKSzVyPUCuNFE2ODJizszN Ml7WV2FPT0WU
C-33-A MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEG1NFkh|ryP MWHTRW5ITVJ?
MIA-PaCa-2 NYTnPYs4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofETWM2OD1yLkCxOVA6KM7:TR?= M1nPTXNCVkeHUh?=
Becker MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:zOWlEPTB;MD6wNVUyPCEQvF2= MWLTRW5ITVJ?
HOP-62 NFKyNXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMEG1OFIh|ryP NYrqPYVqW0GQR1XS
TE-1 NHvteYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUWxc5NZUUN3ME2wMlAyPThzIN88US=> NH;ydXVUSU6JRWK=
KYSE-410 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvlU|NWUUN3ME2wMlAyPTh4IN88US=> NEPyPXhUSU6JRWK=
NOS-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TibmlEPTB;MD6wNVU6OyEQvF2= Mn3lV2FPT0WU
MEL-HO NGr3eXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknYTWM2OD1yLkCxOlQ{KM7:TR?= M2jFNHNCVkeHUh?=
NCI-H1650 MkXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEG2OFYh|ryP NEnGN2pUSU6JRWK=
VMRC-RCZ MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzRdFh5UUN3ME2wMlAyPjVzIN88US=> NHL0cFZUSU6JRWK=
HuP-T3 NGPhSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrNO29KSzVyPUCuNFE3PTNizszN MXTTRW5ITVJ?
ACN M2jrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv2dWhUUUN3ME2wMlAyPjV5IN88US=> MVXTRW5ITVJ?
MEL-JUSO NYTmNWZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1K2NGlEPTB;MD6wNVY5OSEQvF2= NFr6RotUSU6JRWK=
HT-1197 M4TpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEG2PFUh|ryP MnrSV2FPT0WU
NCI-H2030 NF;3b45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoO4TWM2OD1yLkCxOlk4KM7:TR?= MXrTRW5ITVJ?
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SF268 NGLwPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTMeoZqUUN3ME2wMlA{PDBzIN88US=> NEjDZYVUSU6JRWK=
BV-173 NVLTdXBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzQTWM2OD1yLkCzOFI3KM7:TR?= M2TBPHNCVkeHUh?=
DMS-273 MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMEO0O|kh|ryP MnjXV2FPT0WU
22RV1 M{\0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEO1NFch|ryP MmS5V2FPT0WU
ES8 MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEO1N|gh|ryP NX3CbHBoW0GQR1XS
KYSE-150 NVnaVlFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\IfoM5UUN3ME2wMlA{PjB6IN88US=> NHn0VXRUSU6JRWK=
HCC1569 NV3CbWF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknJTWM2OD1yLkCzOlA5KM7:TR?= NFviOnpUSU6JRWK=
NB5 NF;oUJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4GzOGlEPTB;MD6wN|YyOyEQvF2= M{T0U3NCVkeHUh?=
G-402 M2nOWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfaWWpmUUN3ME2wMlA{PjF2IN88US=> M4XyfHNCVkeHUh?=
NCI-H1693 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:3TWM2OD1yLkCzOlE4KM7:TR?= NEHCSXVUSU6JRWK=
LB2241-RCC MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zyUGlEPTB;MD6wN|Y1OiEQvF2= NGHtZXRUSU6JRWK=
KP-4 M4CyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHPTWM2OD1yLkCzOlY{KM7:TR?= M1[2O3NCVkeHUh?=
ML-2 NULVeZQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XIT2lEPTB;MD6wN|Y4OSEQvF2= NEXSN2RUSU6JRWK=
KU812 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfTd5FQUUN3ME2wMlA{Pjh2IN88US=> NGDCU3ZUSU6JRWK=
LS-411N M3e5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEO3N|Eh|ryP NXnGXJFFW0GQR1XS
OAW-42 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMEO3OFch|ryP MVfTRW5ITVJ?
HCC38 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEO3O|Eh|ryP MWLTRW5ITVJ?
Ca-Ski M{OyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPa[21KSzVyPUCuNFM4QDRizszN MlPLV2FPT0WU
Calu-3 M1HDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;kOpBKSzVyPUCuNFM4QDlizszN M4LRPHNCVkeHUh?=
KYSE-70 M3HaUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjrcYhZUUN3ME2wMlA{QDF{IN88US=> MY\TRW5ITVJ?
D-392MG M4HrZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEO4OFIh|ryP M3vFUHNCVkeHUh?=
OVCAR-4 NFy4dVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEO4OVgh|ryP NWDjNJZnW0GQR1XS
Detroit562 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S3VmlEPTB;MD6wN|g4OiEQvF2= NX3Dd41XW0GQR1XS
HEL M{Tsbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\uU3NrUUN3ME2wMlA{QDlzIN88US=> NYTBfZh2W0GQR1XS
MONO-MAC-6 MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmwbpJvUUN3ME2wMlA{QDl|IN88US=> MljkV2FPT0WU
LoVo M4PxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[2dmlEPTB;MD6wN|k{OyEQvF2= NH;WVHZUSU6JRWK=
U-2-OS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHiTm1wUUN3ME2wMlA{QTN3IN88US=> NHiwTG9USU6JRWK=
A172 Moe0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEO5OUDPxE1? NGTWO2VUSU6JRWK=
OCUB-M NYPNS|JmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1eyOWlEPTB;MD6wN|k3OSEQvF2= Mm\pV2FPT0WU
SW48 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMESwN|Eh|ryP MkjGV2FPT0WU
HC-1 Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrZOXA4UUN3ME2wMlA1ODZ7IN88US=> NWfUbFRRW0GQR1XS
KOSC-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfBTWM2OD1yLkC0NVEh|ryP NEHBd4tUSU6JRWK=
HDLM-2 NF\zT4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HHdGlEPTB;MD6wOFEyPCEQvF2= NVzHV|hEW0GQR1XS
CTV-1 NF[zfXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPJTm9KSzVyPUCuNFQyOTZizszN MVXTRW5ITVJ?
SH-4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHBTWM2OD1yLkC0NVQyKM7:TR?= M{juOXNCVkeHUh?=
SW756 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXLNot2UUN3ME2wMlA1OTV5IN88US=> M2Tz[nNCVkeHUh?=
GCT M{nCPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDUcHJbUUN3ME2wMlA1OTZzIN88US=> M1LYd3NCVkeHUh?=
CHL-1 NF\WUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\rVGlEPTB;MD6wOFE3QSEQvF2= NUfKfJJ3W0GQR1XS
LAMA-84 NI\q[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXPTWM2OD1yLkC0NVcyKM7:TR?= MljzV2FPT0WU
LS-1034 NE\UUHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jSeWlEPTB;MD6wOFE6OSEQvF2= M3LSfHNCVkeHUh?=
NCI-H358 NXPjZ3ZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHrUoJIUUN3ME2wMlA1OjF{IN88US=> MX\TRW5ITVJ?
NB13 MmfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vmS2lEPTB;MD6wOFIzPyEQvF2= NITqTotUSU6JRWK=
TE-9 M4rPS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X2eGlEPTB;MD6wOFI{PyEQvF2= NXnwOmpyW0GQR1XS
OE33 NW\mPW17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrBO41KSzVyPUCuNFQzPDFizszN M2HJdnNCVkeHUh?=
CAL-120 NHe0c5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml75TWM2OD1yLkC0NlQyKM7:TR?= MnryV2FPT0WU
DJM-1 NVHJO5FLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HndWlEPTB;MD6wOFI4OiEQvF2= Mnr0V2FPT0WU
SK-MEL-24 NWPuZpdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjvbZd3UUN3ME2wMlA1Ojh|IN88US=> MUnTRW5ITVJ?
VA-ES-BJ M{nT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkW5TWM2OD1yLkC0NlkzKM7:TR?= NXrmOIFxW0GQR1XS
MMAC-SF NFjHc2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMESyPVch|ryP M2nMRnNCVkeHUh?=
MZ7-mel M{TGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:0WmlEPTB;MD6wOFM{KM7:TR?= MkG4V2FPT0WU
BxPC-3 MljBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrRcINKSzVyPUCuNFQ{PDFizszN M2rITnNCVkeHUh?=
HT-29 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrOWIhsUUN3ME2wMlA1OzV5IN88US=> NGf0W5NUSU6JRWK=
SK-MEL-30 Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHjZW1KSzVyPUCuNFQ{PjJizszN MlX4V2FPT0WU
CAL-33 NVLESI9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqxXHRKSzVyPUCuNFQ{PzVizszN MYHTRW5ITVJ?
COLO-680N MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj2TWM2OD1yLkC0OFA4KM7:TR?= M{TFd3NCVkeHUh?=
NH-12 NFzHVpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XXfmlEPTB;MD6wOFQ1KM7:TR?= MWjTRW5ITVJ?
HCC1937 MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHntNo9KSzVyPUCuNFQ1PTZizszN NYS5eXdKW0GQR1XS
IMR-5 NYLRe5BRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{OwPWlEPTB;MD6wOFQ6KM7:TR?= NGHvdZVUSU6JRWK=
MC-CAR NXfqfFFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG2dYx4UUN3ME2wMlA1PTZ7IN88US=> NULjS5REW0GQR1XS
NCI-H747 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMES1O{DPxE1? NHLI[WNUSU6JRWK=
NCI-H1792 NWTjeFdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXETWM2OD1yLkC0OVgyKM7:TR?= M3nlNHNCVkeHUh?=
SW13 M4O0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy1[oxrUUN3ME2wMlA1PTlizszN MW\TRW5ITVJ?
MLMA M2HtUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[yTWM2OD1yLkC0OlA6KM7:TR?= M13NXnNCVkeHUh?=
U251 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fu[mlEPTB;MD6wOFc3OyEQvF2= NIHrU21USU6JRWK=
U031 M17JUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVSyPXE5UUN3ME2wMlA1PzdzIN88US=> M{fXfHNCVkeHUh?=
ME-180 M3TGbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMES3PFIh|ryP MWHTRW5ITVJ?
SK-MEL-3 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMES4NFIh|ryP NFT2c5dUSU6JRWK=
MOLT-4 MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXn1[ol6UUN3ME2wMlA1QDB|IN88US=> MYfTRW5ITVJ?
PF-382 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vPfmlEPTB;MD6wOFgzPiEQvF2= NH3MOHdUSU6JRWK=
NUGC-3 NILa[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PhSGlEPTB;MD6wOFgzPyEQvF2= M3fj[HNCVkeHUh?=
NCI-H1417 NWnOT2llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXSxOnNIUUN3ME2wMlA1QDlizszN NVW0Now4W0GQR1XS
COLO-205 NIHXT|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O0OmlEPTB;MD6wOFkyQSEQvF2= MmKxV2FPT0WU
TE-441-T NULad5R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PE[WlEPTB;MD6wOFk{KM7:TR?= MmWxV2FPT0WU
MKN1 NEHNcpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrRW3pKSzVyPUCuNFQ6OyEQvF2= MoPTV2FPT0WU
UM-UC-3 M1vlfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{izTmlEPTB;MD6wOFk2KM7:TR?= NIWzRZBUSU6JRWK=
SF126 NYTTN496T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEWwNUDPxE1? MVvTRW5ITVJ?
LB1047-RCC NULWb2ZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moq3TWM2OD1yLkC1NFMyKM7:TR?= MYrTRW5ITVJ?
A253 NFO3PVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEWwOVIh|ryP NYXJXVBzW0GQR1XS
NCI-H1963 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEWxO|Yh|ryP MoLSV2FPT0WU
VM-CUB-1 NIfURXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nH[GlEPTB;MD6wOVMyOSEQvF2= M3G3UnNCVkeHUh?=
T-24 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4D4bWlEPTB;MD6wOVM5PCEQvF2= MnLIV2FPT0WU
K-562 M370OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV32d4VsUUN3ME2wMlA2Ozh5IN88US=> Ml3NV2FPT0WU
ARH-77 M2rOcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPvR|FKSzVyPUCuNFU{QTVizszN MV3TRW5ITVJ?
CA46 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEW0N{DPxE1? M1fQOXNCVkeHUh?=
HCC70 MnX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7F[FFKSzVyPUCuNFU1PTJizszN NFjGZYtUSU6JRWK=
ST486 NH:zWXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy3W3VKSzVyPUCuNFU2OjVizszN MlvzV2FPT0WU
COLO-741 M1;vTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37ubGlEPTB;MD6wOVU{OSEQvF2= NW\ve4dZW0GQR1XS
SK-PN-DW NVPPPWl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEW1PFgh|ryP NIrHdFNUSU6JRWK=
BL-41 NWXKbGZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HaeWlEPTB;MD6wOVU6PiEQvF2= NEjwcWdUSU6JRWK=
D-263MG NXX1WmkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXf5Sm9MUUN3ME2wMlA2Pjh|IN88US=> NITLVY9USU6JRWK=
KE-37 M4C0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXHTWM2OD1yLkC1Olg{KM7:TR?= NISyfXRUSU6JRWK=
LU-134-A NEOySYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEW3NVUh|ryP NGGweHFUSU6JRWK=
HCC2157 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;hdGlEPTB;MD6wOVc{OyEQvF2= MkfKV2FPT0WU
GAK M1LwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjYfY9KSzVyPUCuNFU4OzRizszN MWrTRW5ITVJ?
IST-SL2 M3WyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfIRppKSzVyPUCuNFU4PDNizszN MmjyV2FPT0WU
KMOE-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEW3OFkh|ryP NWfCXY9jW0GQR1XS
SW1573 M331NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLVboJIUUN3ME2wMlA2QDB{IN88US=> NX\vWGx{W0GQR1XS
SCC-9 MmjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXTUHJKSzVyPUCuNFU5PyEQvF2= NIPBbZpUSU6JRWK=
MDA-MB-361 MnK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nkZWlEPTB;MD6wOVg4OiEQvF2= Mk[1V2FPT0WU
BHT-101 NWLIeHBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nv[mlEPTB;MD6wOVg4PiEQvF2= MmrOV2FPT0WU
NCI-H1770 NWn2fFd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LPVGlEPTB;MD6wOVg4QSEQvF2= NXi3T4F{W0GQR1XS
UACC-893 NGfTe3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEW4PVYh|ryP MljhV2FPT0WU
NCI-H226 M1[1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljwTWM2OD1yLkC1PVg5KM7:TR?= Mn[2V2FPT0WU
HLE MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\vTWM2OD1yLkC2NFgzKM7:TR?= NYTQfW1xW0GQR1XS
NCI-H1703 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXPbHlKSzVyPUCuNFYyPzhizszN NWP4VVc{W0GQR1XS
KURAMOCHI NXHnR2xLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXJTWM2OD1yLkC2NVg6KM7:TR?= MmK1V2FPT0WU
RH-1 MmLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwME[yN{DPxE1? M3TyZ3NCVkeHUh?=
DSH1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwME[yO{DPxE1? NV3reJY1W0GQR1XS
CAMA-1 M1Lu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXETWM2OD1yLkC2N|A{KM7:TR?= M2HLTXNCVkeHUh?=
NCI-H1437 Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;TRlJVUUN3ME2wMlA3OzJ6IN88US=> MUDTRW5ITVJ?
HuP-T4 Mn7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[3TWM2OD1yLkC2OVg3KM7:TR?= NVuyZ4hDW0GQR1XS
HCT-15 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPYTWM2OD1yLkC2OVk4KM7:TR?= MULTRW5ITVJ?
NCCIT MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTXfIlKSzVyPUCuNFY3ODRizszN MXjTRW5ITVJ?
BOKU NFTrPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\nZXpzUUN3ME2wMlA3Pjd2IN88US=> MVTTRW5ITVJ?
FADU M2XxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fmN2lEPTB;MD6wOlc1PSEQvF2= MWXTRW5ITVJ?
SUP-T1 M3uzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfjTWM2OD1yLkC2O|Yh|ryP NVjteXM4W0GQR1XS
L-363 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDm[WNYUUN3ME2wMlA3QTBzIN88US=> NIf1SVVUSU6JRWK=
KNS-81-FD M1rBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLNWo5EUUN3ME2wMlA3QTF6IN88US=> M3PUXXNCVkeHUh?=
SU-DHL-1 NYfBWIxET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknDTWM2OD1yLkC2PVIh|ryP MWrTRW5ITVJ?
HuH-7 MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf6ZZVKSzVyPUCuNFcxOzVizszN M2PmS3NCVkeHUh?=
BT-474 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjwU|RKSzVyPUCuNFcxPjFizszN Mo[yV2FPT0WU
CAPAN-1 Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorZTWM2OD1yLkC3NVQ{KM7:TR?= MmfEV2FPT0WU
HEC-1 MonKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXrdYt5UUN3ME2wMlA4OTZzIN88US=> NV34ZY1DW0GQR1XS
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NCI-H720 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S4eWlEPTB;Mj6yOlU5PSEQvF2= M{C0e3NCVkeHUh?=
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MC116 NYrK[pIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJwM{[zPVch|ryP MnvtV2FPT0WU
DG-75 NYDrcVBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHvdpVKSzVyPUKuOFg2PzZizszN NVnr[XZbW0GQR1XS
HCC1143 NIjOTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJwNUC2OVgh|ryP M{LGUnNCVkeHUh?=
FTC-133 NEmySGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\tUWlEPTB;Mj61N|Y5QSEQvF2= MWTTRW5ITVJ?
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NCI-H889 MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHGTWM2OD1{LkW2O|A3KM7:TR?= NXf1TpU5W0GQR1XS
HT55 NX22[phWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\LXVVHUUN3ME2yMlYzODF7IN88US=> NHz0SVRUSU6JRWK=
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HCC1395 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nOSGlEPTB;Mj65PFYxOiEQvF2= MorFV2FPT0WU
D-283MED NY\uSld3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfNVHBKSzVyPUOuNVg6OzdizszN NETIPFNUSU6JRWK=
COLO-800 NFXGVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPUZ2s{UUN3ME2zMlM{QDl5IN88US=> M3m2bXNCVkeHUh?=
MFM-223 M1nObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL6TWM2OD1|LkO2NFk4KM7:TR?= NWnSN4pCW0GQR1XS
TE-5 MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjzTWM2OD12LkW2NVQ4KM7:TR?= NVzucmdbW0GQR1XS
NCI-H209 M1XydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2L1PWlEPTB;ND63PFU4OiEQvF2= NU\FPIU5W0GQR1XS
SiHa Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILFbIpKSzVyPUSuPVUzODNizszN MV3TRW5ITVJ?
NCI-H1395 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHve5BZUUN3ME21MlExPjN|IN88US=> NHTWcWtUSU6JRWK=
A498 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfMS4ZKSzVyPUWuNlEzPTFizszN M4\hOXNCVkeHUh?=
ES5 NWnxZ4xiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4naZmlEPTB;NT62NVE4QCEQvF2= MoXoV2FPT0WU
MDA-MB-157 NGTYfFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHkTWM2OD13Lk[2OFQ{KM7:TR?= NXXvR44zW0GQR1XS
NCI-H1623 Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HnXWlEPTB;NT64N|U2PiEQvF2= NXvXPJNUW0GQR1XS
RPMI-8866 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTVwOES3PVIh|ryP NUH2d5dEW0GQR1XS
LC-1F M3vjd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHYUINKSzVyPU[uNFkzQTFizszN M3LPNXNCVkeHUh?=
TCCSUP NEn4e5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4T4OWlEPTB;Nj62NFM1QSEQvF2= MUnTRW5ITVJ?
TT NWPqTVg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRThwM{OwNFkh|ryP NEDWfpZUSU6JRWK=
NCI-H1838 MmXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTXTWM2OD16LkWxO|MyKM7:TR?= NVvIeYhjW0GQR1XS
NCI-H322M NV;aTWlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LEcWlEPTB;OT6xOlI5OSEQvF2= NILUc4RUSU6JRWK=
NCI-H187 NGrzSpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTlwNUG4N|Uh|ryP M2XH[3NCVkeHUh?=
SBC-1 NGHXNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4THbWlEPTB;OT65N|Y2PiEQvF2= MnXhV2FPT0WU
SCC-3 M2S2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFyLkW2O|kh|ryP M{fkZXNCVkeHUh?=
SW948 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzhfWxIUUN3ME2xNE44PTFzIN88US=> NYXONoxrW0GQR1XS
CPC-N MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL5TWM2OD1zMT6wNFch|ryP M2XQeXNCVkeHUh?=
TGBC24TKB NXvwb3MzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF|LkWyPUDPxE1? NE\hXYRUSU6JRWK=
NCI-H2452 NH3pZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO4V|lOUUN3ME2xOE44OyEQvF2= MYnTRW5ITVJ?
Hs-578-T MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF6LkW3OVkh|ryP M2C3PHNCVkeHUh?=
DV-90 MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;0epVKSzVyPUG4Mlk6PDVizszN M2\1bHNCVkeHUh?=
NCI-H1563 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPWc3pKSzVyPUG5Mlc5QDhizszN MkL6V2FPT0WU
SW780 Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvWTWM2OD1{MT6xN|E5KM7:TR?= MkizV2FPT0WU
NCI-H345 NHfafFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vzU2lEPTB;MkGuPFc4QSEQvF2= MWnTRW5ITVJ?
LB771-HNC MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf0TYtKSzVyPUKyMlQ5OTNizszN NEXWRnpUSU6JRWK=
RT4 NIjYZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlK4TWM2OD1{Mz6zNlgzKM7:TR?= MlnwV2FPT0WU
NCI-H82 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ|LkW1NlYh|ryP NWPkVpZyW0GQR1XS
NCI-H524 NXP0fGhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJ2LkO4NVIh|ryP MYDTRW5ITVJ?
SNU-C1 NGHCSVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJ2LkmxNFUh|ryP M3zmV3NCVkeHUh?=
NCI-SNU-16 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17q[mlEPTB;NEiuN|E1OiEQvF2= NUfkW4tPW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

細胞アッセイ: [1]

細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

動物実験: [3]

動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
製剤 In DMSO and diluted in sterile saline/Tween 20
投薬量 50 mg/kg
投与方法 Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Luminespib (AUY-922, NVP-AUY922) SDF
分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管 2年-20℃
6月-80℃in solvent
別名 VER-52296
溶解度 (25°C) * In vitro DMSO 93 mg/mL warmed (199.76 mM)
エタノール 31 mg/mL (66.58 mM)
<1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

カスタマーフィードバック (3)


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Rating
Source , , Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck
Method Immunostaining
Cell Lines U2OS_exo cells
Concentrations 4 µM
Incubation Time 20 h
Results AUY922 blocked nuclear migration of RelA/p50 induced by TNFα in a dose-dependent manner, consistent with the notion that Hsp90 is required for activation of the NF-κB pathway.

Click to enlarge
Rating
Source J Biol Chem, 2013, 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck
Method Western blot
Cell Lines 293T cells
Concentrations 1 uM
Incubation Time 16 h
Results Treatment of cellswith each of these HSP90 inhibitors (17-AAG, SNX-5422, or NVP-AUY922) caused a significant reduction in TSSK1, -2, -4, and -6 in the cells.

Click to enlarge
Rating
Source 2011, Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck
Method Western blot
Cell Lines BT474 breast cancer cell line
Concentrations 1.0 ± 0.1 nM
Incubation Time 8/24 h
Results Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922.

文献中の引用 (23)

技術サポート&よくある質問(FAQ)

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Related HSP (e.g. HSP90) 阻害剤

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.

  • KNK437

    KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

  • VER155008

    VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

  • FRAX597

    FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.

  • 17-AAG (Tanespimycin)

    17-AAG (Tanespimycin)は、5nMのIC50による強力な熱ショックタンパク質90(Hsp90)阻害剤です。

    Features:Displays very low toxicity toward normal cells.

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090)は独特な triazolone-containing Hsp90阻害剤、 IC50 が4 nM となる.

  • 17-DMAG (Alvespimycin) HCl

    17-DMAG (Alvespimycin) HClは、62nMのIC50による強力なHsp90阻害剤です。

    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    ノーカット二量体Hsp90またはN末端領域Hsp90と結合している間、Geldanamycinは1.2のμMまたは0.78のμMによるKdによる天然既存のHsp90阻害剤です。

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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