Luminespib (AUY-922, NVP-AUY922) 化学構造
分子量: 465.54

高品質保証

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Quality Control & MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野
  • Luminespib (AUY-922, NVP-AUY922)のメカニズム

製品の説明

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。
ターゲット HSP90α HSP90β
IC50 13 nM 21 nM [1]
In vitro試験 NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMK NID6dGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvt[mxDUUN3ME2wMlAxODF{NTFOwG0> NUTT[5hUW0GQR1XS
MV-4-11 NGG2cFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMECwOVU5KM7:TR?= M4n5ZnNCVkeHUh?=
NALM-6 M3v1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMECwPFQzKM7:TR?= NW\YRoFwW0GQR1XS
HOS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMECxN|gh|ryP MYXTRW5ITVJ?
HT-144 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF33PXFKSzVyPUCuNFAyPTVizszN MlTUV2FPT0WU
SW1710 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPXcIVKSzVyPUCuNFAyQDZizszN M2LtfXNCVkeHUh?=
TE-8 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMECyN|ch|ryP NXn4dnBZW0GQR1XS
ES1 Mn;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK3c5JKSzVyPUCuNFAzPjZizszN NWG0OVd6W0GQR1XS
CCF-STTG1 MknkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjYTWM2OD1yLkCwNlk4KM7:TR?= NVSyeXJ{W0GQR1XS
PSN1 M1m3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;hVmlEPTB;MD6wNFMyQCEQvF2= MW\TRW5ITVJ?
CAL-51 Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMECzNlUh|ryP NX;5fGRpW0GQR1XS
MCF7 NVnXPY9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPVVXVKSzVyPUCuNFA{OzVizszN NYK0dHliW0GQR1XS
SK-HEP-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfLWXVYUUN3ME2wMlAxOzN4IN88US=> MX3TRW5ITVJ?
LCLC-103H NWHkbJFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHuTWM2OD1yLkCwOFMh|ryP MX;TRW5ITVJ?
HMV-II MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETDXHBKSzVyPUCuNFA1PDlizszN NGWwPWpUSU6JRWK=
MES-SA NGPNN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvNTWM2OD1yLkCwOFUzKM7:TR?= NUnUcno1W0GQR1XS
SK-LMS-1 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3DSFBKSzVyPUCuNFA1PThizszN MWrTRW5ITVJ?
639-V M4jGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HQWmlEPTB;MD6wNFQ5PSEQvF2= NFvWeIlUSU6JRWK=
SIG-M5 M{Htdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEC0PFkh|ryP MoCzV2FPT0WU
LOUCY MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn4cm1pUUN3ME2wMlAxPTB3IN88US=> NIfLN2lUSU6JRWK=
HSC-2 NUfPW5pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljOTWM2OD1yLkCwOVE5KM7:TR?= MWnTRW5ITVJ?
EW-13 NVj6SnVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEC1NVgh|ryP MkGwV2FPT0WU
RT-112 M2DzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEC1N|Uh|ryP MnHYV2FPT0WU
NKM-1 Ml7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEC1OFch|ryP NXfndmxGW0GQR1XS
KYSE-180 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzQW2dKSzVyPUCuNFA2QDZizszN MXzTRW5ITVJ?
SW1783 NYfJVlI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTSWYVKSzVyPUCuNFA2QTFizszN NXLuNndZW0GQR1XS
A431 NW\ZZ3d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TwR2lEPTB;MD6wNFYxPyEQvF2= NIrI[llUSU6JRWK=
SK-OV-3 M17YV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\MR4pKSzVyPUCuNFA3OyEQvF2= NYG4[FR1W0GQR1XS
RPMI-7951 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEC2N|Eh|ryP MUjTRW5ITVJ?
Capan-2 M{LhXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37lPWlEPTB;MD6wNFY{QCEQvF2= NH;rd5lUSU6JRWK=
HSC-3 NIKxTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P5VWlEPTB;MD6wNFY1OSEQvF2= Mmr4V2FPT0WU
786-0 M3nSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3McItKSzVyPUCuNFA3PjNizszN NF:zUndUSU6JRWK=
Daoy NGXVUYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\qcnpKSzVyPUCuNFA3QTVizszN NVXzPZFMW0GQR1XS
KGN Mm\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fxbmlEPTB;MD6wNFcxOyEQvF2= M2jnSXNCVkeHUh?=
EW-16 M2n6dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEC3OFkh|ryP MnvwV2FPT0WU
EW-7 NIHiV4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO0UoJLUUN3ME2wMlAxPzV2IN88US=> MonSV2FPT0WU
IGROV-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD3fJlxUUN3ME2wMlAxQDF2IN88US=> NVntOY9WW0GQR1XS
8505C M3zwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\hSYpQUUN3ME2wMlAxQDJzIN88US=> NX\wfY1{W0GQR1XS
RKO MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHocZYxUUN3ME2wMlAxQDJ4IN88US=> NVPnTZdyW0GQR1XS
GDM-1 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DQOGlEPTB;MD6wNFg1KM7:TR?= NXzkU3EyW0GQR1XS
IST-MEL1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\nTWM2OD1yLkCwPFUzKM7:TR?= MV;TRW5ITVJ?
RPMI-6666 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUGyVYEyUUN3ME2wMlAxQDV{IN88US=> MkezV2FPT0WU
SNG-M M{\6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEC4OVYh|ryP M3TaSHNCVkeHUh?=
KS-1 NGLQW5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnlRohxUUN3ME2wMlAxQDV7IN88US=> NVW4WXB3W0GQR1XS
RXF393 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3ZTWM2OD1yLkCwPFYh|ryP NWqzdHhpW0GQR1XS
CAL-12T MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEC5NlIh|ryP Mn7FV2FPT0WU
BFTC-905 M4rCc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1foTGlEPTB;MD6wNFk{QCEQvF2= MXHTRW5ITVJ?
SK-MES-1 NWXpOmR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILG[m1KSzVyPUCuNFA6PDVizszN NFzDTGFUSU6JRWK=
BB30-HNC MmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HGR2lEPTB;MD6wNFk2OiEQvF2= NGm0cY1USU6JRWK=
AN3-CA MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvaU2dKSzVyPUCuNFExOTdizszN NVT2eJo6W0GQR1XS
EFO-27 M1;qZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjDOWM3UUN3ME2wMlAyODF5IN88US=> MlHIV2FPT0WU
G-401 M1\lemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEGwNlUh|ryP M2j6e3NCVkeHUh?=
BPH-1 NHPReo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LnfmlEPTB;MD6wNVA{KM7:TR?= NEjFdIhUSU6JRWK=
NCI-H727 MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXzVYp3UUN3ME2wMlAyODNizszN NXrOWGRwW0GQR1XS
SNU-423 MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rQbmlEPTB;MD6wNVA2OyEQvF2= NYLJSGVrW0GQR1XS
KYSE-270 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnoPIM1UUN3ME2wMlAyODV7IN88US=> NGXscJZUSU6JRWK=
AGS NWTqSJEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rCcWlEPTB;MD6wNVA3OSEQvF2= NFHINpVUSU6JRWK=
NCI-H2228 MnnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;RTWM2OD1yLkCxNFY1KM7:TR?= NILFOmxUSU6JRWK=
SW954 NVXH[Gl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEGwO|Eh|ryP NXHIZYhxW0GQR1XS
769-P NFfMeFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nlSWlEPTB;MD6wNVA4OyEQvF2= Mnm3V2FPT0WU
BB49-HNC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf5eJZPUUN3ME2wMlAyODd5IN88US=> NULQeWxLW0GQR1XS
IA-LM Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW2doN1UUN3ME2wMlAyODh4IN88US=> MVHTRW5ITVJ?
NB69 MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnPNHRJUUN3ME2wMlAyOTB{IN88US=> M1v3W3NCVkeHUh?=
C8166 MoTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEGxNlkh|ryP M3H1S3NCVkeHUh?=
NCI-H1299 Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojwTWM2OD1yLkCxNVU1KM7:TR?= MoPRV2FPT0WU
YKG-1 Mk\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknnTWM2OD1yLkCxNVYh|ryP M{jLcnNCVkeHUh?=
PANC-03-27 MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjqXpVKSzVyPUCuNFEyPjJizszN MmflV2FPT0WU
YT NFLydWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEGxO|kh|ryP MVjTRW5ITVJ?
CAL-85-1 MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LzT2lEPTB;MD6wNVE6OiEQvF2= MoPkV2FPT0WU
GT3TKB MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ntWWlEPTB;MD6wNVIxOiEQvF2= M2XyN3NCVkeHUh?=
BB65-RCC M1TB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTpTWM2OD1yLkCxNlA1KM7:TR?= NWHyUYI6W0GQR1XS
ES6 M4jYV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDpTWM2OD1yLkCxNlYyKM7:TR?= NV:0TJlCW0GQR1XS
MHH-ES-1 MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLsTWM2OD1yLkCxNlY{KM7:TR?= NULMOpRtW0GQR1XS
QIMR-WIL MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f6RmlEPTB;MD6wNVI3QSEQvF2= NETXU|dUSU6JRWK=
SNU-C2B NF3HeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;EXWlEPTB;MD6wNVI4OiEQvF2= MVrTRW5ITVJ?
OCI-AML2 NWLxNoRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIq1TG9KSzVyPUCuNFEzQDFizszN Mm\sV2FPT0WU
DU-145 NG[zdlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDJNlNNUUN3ME2wMlAyOjlizszN Mk\5V2FPT0WU
SW982 M3P0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjQfIhNUUN3ME2wMlAyOjl|IN88US=> MkLLV2FPT0WU
MFH-ino MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEGyPVMh|ryP M17IfHNCVkeHUh?=
A427 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPWbXJlUUN3ME2wMlAyOjl7IN88US=> MX;TRW5ITVJ?
LCLC-97TM1 NXniOWVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjsTFVKSzVyPUCuNFE{KM7:TR?= M1nxeXNCVkeHUh?=
AM-38 NEj0TmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jvdGlEPTB;MD6wNVMxOiEQvF2= MoD5V2FPT0WU
K5 NGTTNWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEGzNFgh|ryP MXrTRW5ITVJ?
T84 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\CTWM2OD1yLkCxN|MyKM7:TR?= M4LPbXNCVkeHUh?=
TE-15 M33rVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPDXIJKUUN3ME2wMlAyOzN4IN88US=> M4S1R3NCVkeHUh?=
NCI-H460 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLkTWM2OD1yLkCxN|M3KM7:TR?= NXK2SHY{W0GQR1XS
NTERA-S-cl-D1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEGzN|kh|ryP MlK1V2FPT0WU
KYSE-450 NWTmW3l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonwTWM2OD1yLkCxN|Q6KM7:TR?= MVLTRW5ITVJ?
H4 M1LVUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHkcWxMUUN3ME2wMlAyOzZ4IN88US=> Mlz6V2FPT0WU
LC-2-ad MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHITWM2OD1yLkCxN|ch|ryP MWLTRW5ITVJ?
GAMG NUXqWlN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPDe5E5UUN3ME2wMlAyOzdzIN88US=> MmPSV2FPT0WU
TK10 MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMEGzPFIh|ryP MnfLV2FPT0WU
NCI-H2122 M4Pjdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnt[3o4UUN3ME2wMlAyOzh2IN88US=> MkK5V2FPT0WU
KM12 MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK4c|NKSzVyPUCuNFE{QTlizszN M4ftZ3NCVkeHUh?=
CAL-39 NX7URXFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\0fWlEPTB;MD6wNVQzKM7:TR?= MVXTRW5ITVJ?
RPMI-2650 M2nORmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIK5enpKSzVyPUCuNFE1OzJizszN MX;TRW5ITVJ?
KYSE-510 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[5TWM2OD1yLkCxOFQzKM7:TR?= NInESldUSU6JRWK=
KALS-1 MoHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XmN2lEPTB;MD6wNVQ3PiEQvF2= MmPCV2FPT0WU
NCI-H1648 MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XwPGlEPTB;MD6wNVQ6QSEQvF2= NGXZbHdUSU6JRWK=
ES4 M4rEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T1SGlEPTB;MD6wNVUxOiEQvF2= MnzFV2FPT0WU
C-33-A M3iyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml74TWM2OD1yLkCxOVA6KM7:TR?= NF3jN2dUSU6JRWK=
MIA-PaCa-2 Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm3NXNVUUN3ME2wMlAyPTB7IN88US=> NXHNV3RwW0GQR1XS
Becker M3PSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\kTWM2OD1yLkCxOVE1KM7:TR?= MlzHV2FPT0WU
HOP-62 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEG1OFIh|ryP NF60[ndUSU6JRWK=
TE-1 M3zOVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r4bWlEPTB;MD6wNVU5OSEQvF2= NHzaVYNUSU6JRWK=
KYSE-410 Mmm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXPfnNKSzVyPUCuNFE2QDZizszN MXXTRW5ITVJ?
NOS-1 NYrxTmNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv5b|BqUUN3ME2wMlAyPTl|IN88US=> MYfTRW5ITVJ?
MEL-HO MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zzRmlEPTB;MD6wNVY1OyEQvF2= NEW3fGVUSU6JRWK=
NCI-H1650 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLwR5NKSzVyPUCuNFE3PDZizszN NXy3PXcyW0GQR1XS
VMRC-RCZ NV;SPJlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TyXWlEPTB;MD6wNVY2OSEQvF2= NVSwOGJiW0GQR1XS
HuP-T3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjxTWM2OD1yLkCxOlU{KM7:TR?= M{D6PXNCVkeHUh?=
ACN MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnve2RFUUN3ME2wMlAyPjV5IN88US=> NY\qd5g{W0GQR1XS
MEL-JUSO MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfrNYdKSzVyPUCuNFE3QDFizszN NXu0cHE4W0GQR1XS
HT-1197 MoLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PVdGlEPTB;MD6wNVY5PSEQvF2= MYrTRW5ITVJ?
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KYSE-150 NVu4bFlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qwSmlEPTB;MD6wN|YxQCEQvF2= MVzTRW5ITVJ?
HCC1569 MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnKwTWM2OD1yLkCzOlA5KM7:TR?= MmC3V2FPT0WU
NB5 M2\x[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4q1O2lEPTB;MD6wN|YyOyEQvF2= M2jaXXNCVkeHUh?=
G-402 NVPsUY1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEO2NVQh|ryP NHTpNJBUSU6JRWK=
NCI-H1693 Ml7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEO2NVch|ryP M{Sx[HNCVkeHUh?=
LB2241-RCC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvJTFVTUUN3ME2wMlA{PjR{IN88US=> MYLTRW5ITVJ?
KP-4 MoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnsTWM2OD1yLkCzOlY{KM7:TR?= NHfidJZUSU6JRWK=
ML-2 MorwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEO2O|Eh|ryP MYDTRW5ITVJ?
KU812 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMEO2PFQh|ryP M2fPcXNCVkeHUh?=
LS-411N NWTadpE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPsTWM2OD1yLkCzO|MyKM7:TR?= M4LqT3NCVkeHUh?=
OAW-42 M1r1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEO3OFch|ryP NX7kTINHW0GQR1XS
HCC38 NWKzU|BkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEO3O|Eh|ryP NILXN5RUSU6JRWK=
Ca-Ski NVLHTIw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETlbo1KSzVyPUCuNFM4QDRizszN NHPyZ4lUSU6JRWK=
Calu-3 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLjTWM2OD1yLkCzO|g6KM7:TR?= MnHKV2FPT0WU
KYSE-70 M2DrfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFX6O3lKSzVyPUCuNFM5OTJizszN MkL5V2FPT0WU
D-392MG NUjZN2VlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEO4OFIh|ryP NVfwd5VNW0GQR1XS
OVCAR-4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nueGlEPTB;MD6wN|g2QCEQvF2= M1LMeXNCVkeHUh?=
Detroit562 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEO4O|Ih|ryP NVXTRZlyW0GQR1XS
HEL Mo\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTYbmJKSzVyPUCuNFM5QTFizszN M{ThVnNCVkeHUh?=
MONO-MAC-6 M4fPN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPY[5dKSzVyPUCuNFM5QTNizszN M2\POHNCVkeHUh?=
LoVo NFXOXZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfWXmRJUUN3ME2wMlA{QTN|IN88US=> MWXTRW5ITVJ?
U-2-OS M3P0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnxbINKSzVyPUCuNFM6OzVizszN MXjTRW5ITVJ?
A172 M{GwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLGXXRwUUN3ME2wMlA{QTVizszN M3rvSnNCVkeHUh?=
OCUB-M M17qO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHLdIhYUUN3ME2wMlA{QTZzIN88US=> MVzTRW5ITVJ?
SW48 NITD[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXjTWM2OD1yLkC0NFMyKM7:TR?= NIj6RppUSU6JRWK=
HC-1 M3HLZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vJOmlEPTB;MD6wOFA3QSEQvF2= NYXLdZN3W0GQR1XS
KOSC-2 MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm1eo9KSzVyPUCuNFQyOSEQvF2= NW\PNIR5W0GQR1XS
HDLM-2 NFL1SlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\CTWM2OD1yLkC0NVE1KM7:TR?= Mo\wV2FPT0WU
CTV-1 NVPiZVNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMESxNVYh|ryP NYG5T3NbW0GQR1XS
SH-4 Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf4bHVKSzVyPUCuNFQyPDFizszN M1\DUnNCVkeHUh?=
SW756 M1Lxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMESxOVch|ryP M1\qXnNCVkeHUh?=
GCT MmT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoCzTWM2OD1yLkC0NVYyKM7:TR?= NWrOPIE2W0GQR1XS
CHL-1 NX7mRVlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX3bmwxUUN3ME2wMlA1OTZ7IN88US=> NUDYepd2W0GQR1XS
LAMA-84 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlroTWM2OD1yLkC0NVcyKM7:TR?= NHLMe41USU6JRWK=
LS-1034 NFLsVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHtUpNNUUN3ME2wMlA1OTlzIN88US=> NEPUc|VUSU6JRWK=
NCI-H358 Mn20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLNR4lKSzVyPUCuNFQzOTJizszN Ml7iV2FPT0WU
NB13 NH7QeIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzXTWM2OD1yLkC0NlI4KM7:TR?= MUXTRW5ITVJ?
TE-9 M2fCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfKVXJKSzVyPUCuNFQzOzdizszN MYXTRW5ITVJ?
OE33 NYm3U5JlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NISyOWZKSzVyPUCuNFQzPDFizszN MofDV2FPT0WU
CAL-120 NVXDToVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPZVWhXUUN3ME2wMlA1OjRzIN88US=> NHfv[GRUSU6JRWK=
DJM-1 Mnz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMESyO|Ih|ryP MkXRV2FPT0WU
SK-MEL-24 NFv5SoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXSzdZFrUUN3ME2wMlA1Ojh|IN88US=> MnLWV2FPT0WU
VA-ES-BJ NXTw[IdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLtVJB3UUN3ME2wMlA1Ojl{IN88US=> MnHDV2FPT0WU
MMAC-SF NYG2VmR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDXTZFKSzVyPUCuNFQzQTdizszN M3fEW3NCVkeHUh?=
MZ7-mel M3Lxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjVU5BKSzVyPUCuNFQ{OyEQvF2= Ml70V2FPT0WU
BxPC-3 M3mwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzFeZk5UUN3ME2wMlA1OzRzIN88US=> NGPlR3pUSU6JRWK=
HT-29 NVjn[I86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnxWGF1UUN3ME2wMlA1OzV5IN88US=> M{XUOnNCVkeHUh?=
SK-MEL-30 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMESzOlIh|ryP M4LFUXNCVkeHUh?=
CAL-33 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rJVmlEPTB;MD6wOFM4PSEQvF2= M{SwdHNCVkeHUh?=
COLO-680N MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjNTWM2OD1yLkC0OFA4KM7:TR?= MWrTRW5ITVJ?
NH-12 NFT5OY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPrdJdKSzVyPUCuNFQ1PCEQvF2= MlPNV2FPT0WU
HCC1937 M2\I[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXDN25KSzVyPUCuNFQ1PTZizszN NGjNU29USU6JRWK=
IMR-5 NXS1WHpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF76TlFKSzVyPUCuNFQ1QSEQvF2= NEDTeZVUSU6JRWK=
MC-CAR MnrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIGzO2tKSzVyPUCuNFQ2PjlizszN M1fYWnNCVkeHUh?=
NCI-H747 M2PaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zmUWlEPTB;MD6wOFU4KM7:TR?= MmfFV2FPT0WU
NCI-H1792 NHi5Z|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMES1PFEh|ryP MoroV2FPT0WU
SW13 NGjYb4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rDVWlEPTB;MD6wOFU6KM7:TR?= Mn23V2FPT0WU
MLMA Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMES2NFkh|ryP NGDHR4xUSU6JRWK=
U251 M2nu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvHTWM2OD1yLkC0O|Y{KM7:TR?= MXPTRW5ITVJ?
U031 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMES3O|Eh|ryP MX\TRW5ITVJ?
ME-180 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXvblFNUUN3ME2wMlA1Pzh{IN88US=> NH;rOmJUSU6JRWK=
SK-MEL-3 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMES4NFIh|ryP NETZO|NUSU6JRWK=
MOLT-4 NFv6Tm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHCb2VKSzVyPUCuNFQ5ODNizszN MWrTRW5ITVJ?
PF-382 NGjpfWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7Y[29KUUN3ME2wMlA1QDJ4IN88US=> M2DKfnNCVkeHUh?=
NUGC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXLTWM2OD1yLkC0PFI4KM7:TR?= NGnme5dUSU6JRWK=
NCI-H1417 NW\4W294T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTJTWM2OD1yLkC0PFkh|ryP M13IN3NCVkeHUh?=
COLO-205 NI\5WIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXYR3R{UUN3ME2wMlA1QTF7IN88US=> MljrV2FPT0WU
TE-441-T NGr0eVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMES5N{DPxE1? NVWwcWdSW0GQR1XS
MKN1 M2PSSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMES5N{DPxE1? M4TsTnNCVkeHUh?=
UM-UC-3 NIDHb|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PYWGlEPTB;MD6wOFk2KM7:TR?= M{C0enNCVkeHUh?=
SF126 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PIVGlEPTB;MD6wOVAyKM7:TR?= NHSzdFZUSU6JRWK=
LB1047-RCC M1S4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvwTWM2OD1yLkC1NFMyKM7:TR?= M4e4bHNCVkeHUh?=
A253 NFvzbZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKwTWM2OD1yLkC1NFUzKM7:TR?= MWrTRW5ITVJ?
NCI-H1963 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzJbm9KSzVyPUCuNFUyPzZizszN MYPTRW5ITVJ?
VM-CUB-1 MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7qTWM2OD1yLkC1N|EyKM7:TR?= MVPTRW5ITVJ?
T-24 NH3ufYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofjTWM2OD1yLkC1N|g1KM7:TR?= NXKzTFJLW0GQR1XS
K-562 M4fxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDyTFMyUUN3ME2wMlA2Ozh5IN88US=> MYfTRW5ITVJ?
ARH-77 M3m1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XhR2lEPTB;MD6wOVM6PSEQvF2= MVvTRW5ITVJ?
CA46 NFPqR4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\oTWM2OD1yLkC1OFMh|ryP MlnYV2FPT0WU
HCC70 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEW0OVIh|ryP MXTTRW5ITVJ?
ST486 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fWfWlEPTB;MD6wOVUzPSEQvF2= NX[2bXF6W0GQR1XS
COLO-741 NIW3NoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:xTWM2OD1yLkC1OVMyKM7:TR?= M2[5T3NCVkeHUh?=
SK-PN-DW NGDVU2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMEW1PFgh|ryP MnTjV2FPT0WU
BL-41 NHfWR4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;Tb5JKSzVyPUCuNFU2QTZizszN NWfib5FnW0GQR1XS
D-263MG NYCzW5NVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\xVlhpUUN3ME2wMlA2Pjh|IN88US=> NECxOoxUSU6JRWK=
KE-37 MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEW2PFMh|ryP Ml7qV2FPT0WU
LU-134-A NFPFO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPaTWM2OD1yLkC1O|E2KM7:TR?= M3rOdXNCVkeHUh?=
HCC2157 M3mze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPrTYVKSzVyPUCuNFU4OzNizszN NHLxN4xUSU6JRWK=
GAK MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETmd5VKSzVyPUCuNFU4OzRizszN MUHTRW5ITVJ?
IST-SL2 NVPZV2RUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfxTWM2OD1yLkC1O|Q{KM7:TR?= NXvsZY5sW0GQR1XS
KMOE-2 NEP4Z4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELmUIdKSzVyPUCuNFU4PDlizszN Ml:0V2FPT0WU
SW1573 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknyTWM2OD1yLkC1PFAzKM7:TR?= NI\NVYhUSU6JRWK=
SCC-9 M4qwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf4TWM2OD1yLkC1PFch|ryP M{TNbXNCVkeHUh?=
MDA-MB-361 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXzTWM2OD1yLkC1PFczKM7:TR?= MXTTRW5ITVJ?
BHT-101 NVXwdHhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrPPXpKSzVyPUCuNFU5PzZizszN MW\TRW5ITVJ?
NCI-H1770 NVfXV2ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEW4O|kh|ryP M3;vbnNCVkeHUh?=
UACC-893 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXUUndKSzVyPUCuNFU5QTZizszN NGrUV21USU6JRWK=
NCI-H226 NH\md3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMEW5PFgh|ryP MUDTRW5ITVJ?
HLE MnTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwME[wPFIh|ryP MlexV2FPT0WU
NCI-H1703 NEHjUGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3v6OWlEPTB;MD6wOlE4QCEQvF2= M4\RVnNCVkeHUh?=
KURAMOCHI MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XOXGlEPTB;MD6wOlE5QSEQvF2= NILVR3FUSU6JRWK=
RH-1 M1[zbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HyWWlEPTB;MD6wOlI{KM7:TR?= MXLTRW5ITVJ?
DSH1 NW\TeJFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzy[JhYUUN3ME2wMlA3OjdizszN M2CzbnNCVkeHUh?=
CAMA-1 M3jXNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy0dYhGUUN3ME2wMlA3OzB|IN88US=> MYjTRW5ITVJ?
NCI-H1437 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwME[zNlgh|ryP MV;TRW5ITVJ?
HuP-T4 MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwME[1PFYh|ryP NYL4Zos1W0GQR1XS
HCT-15 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3lbnRGUUN3ME2wMlA3PTl5IN88US=> M{XoeHNCVkeHUh?=
NCCIT NXTxNVI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwME[2NFQh|ryP M4TWdnNCVkeHUh?=
BOKU MoPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PKNGlEPTB;MD6wOlY4PCEQvF2= M1TzVXNCVkeHUh?=
FADU Mnq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC5dHBKSzVyPUCuNFY4PDVizszN NUnub2hbW0GQR1XS
SUP-T1 NHjOWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XodmlEPTB;MD6wOlc3KM7:TR?= MmjsV2FPT0WU
L-363 NXfuPY1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe3SFJmUUN3ME2wMlA3QTBzIN88US=> M3LRUHNCVkeHUh?=
KNS-81-FD MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwME[5NVgh|ryP Ml;SV2FPT0WU
SU-DHL-1 M1rFTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLP[FdPUUN3ME2wMlA3QTJizszN M130dHNCVkeHUh?=
HuH-7 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYO5S3BoUUN3ME2wMlA4ODN3IN88US=> NI\OZXlUSU6JRWK=
BT-474 NGHsbGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfue49KSzVyPUCuNFcxPjFizszN NFPFcohUSU6JRWK=
CAPAN-1 Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFT3V5RKSzVyPUCuNFcyPDNizszN MVfTRW5ITVJ?
HEC-1 NED4WHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEexOlEh|ryP NUf1VVB{W0GQR1XS
NOMO-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17SV2lEPTB;MD6wO|E4OiEQvF2= NVjjeWxWW0GQR1XS
KM-H2 MoD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jLeWlEPTB;MD6wO|I1OSEQvF2= MYXTRW5ITVJ?
EB2 MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEeyPFUh|ryP MlLhV2FPT0WU
LU-99A NISzVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3FVG9KSzVyPUCuNFczQDdizszN M3;YeXNCVkeHUh?=
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EM-2 M1O2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJwMkCyPVMh|ryP MnnkV2FPT0WU
Mewo NVLZUXNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofnTWM2OD1{LkKyNlY2KM7:TR?= NInjS5JUSU6JRWK=
NCI-H720 NGnxTmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHHdHJKSzVyPUKuNlY2QDVizszN MVHTRW5ITVJ?
CAL-54 NFLrZlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrwd2lbUUN3ME2yMlI3Pzl3IN88US=> MV\TRW5ITVJ?
MC116 M4TaVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PlR2lEPTB;Mj6zOlM6PyEQvF2= NIjIeYRUSU6JRWK=
DG-75 NH24elRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\XVJRKSzVyPUKuOFg2PzZizszN NHzHZmxUSU6JRWK=
HCC1143 M3:0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTWR3ZKSzVyPUKuOVA3PThizszN NYjLeJJ3W0GQR1XS
FTC-133 M2f6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;VOJBsUUN3ME2yMlU{Pjh7IN88US=> Ml24V2FPT0WU
AsPC-1 NYrMZ24xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv3WFlvUUN3ME2yMlU{QTJ7IN88US=> M1PoU3NCVkeHUh?=
NCI-H889 NV24dFhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHve2x3UUN3ME2yMlU3PzB4IN88US=> NXnIWlBPW0GQR1XS
HT55 MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjxTWM2OD1{Lk[yNFE6KM7:TR?= MYPTRW5ITVJ?
UMC-11 M{LQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJwN{i3NVUh|ryP NX36PVNZW0GQR1XS
P12-ICHIKAWA MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm4TWM2OD1{LkiyNFQ3KM7:TR?= NX;5eGNFW0GQR1XS
HCC1395 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITYTVdKSzVyPUKuPVg3ODJizszN NIDpfIxUSU6JRWK=
D-283MED MljZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjFTWM2OD1|LkG4PVM4KM7:TR?= NVq2XIdxW0GQR1XS
COLO-800 M1nDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTNwM{O4PVch|ryP NHvB[lZUSU6JRWK=
MFM-223 M4L6NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPSRmZwUUN3ME2zMlM3ODl5IN88US=> M{HCUXNCVkeHUh?=
TE-5 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHxN2pKSzVyPUSuOVYyPDdizszN M3rmXnNCVkeHUh?=
NCI-H209 M13UWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP4e3dKSzVyPUSuO|g2PzJizszN NHTNcGhUSU6JRWK=
SiHa MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj5V3N2UUN3ME20Mlk2OjB|IN88US=> NIrTbGNUSU6JRWK=
NCI-H1395 NV[xd3I2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTVwMUC2N|Mh|ryP MmTUV2FPT0WU
A498 MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlflTWM2OD13LkKxNlUyKM7:TR?= NHPp[XpUSU6JRWK=
ES5 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHWTWM2OD13Lk[xNVc5KM7:TR?= NHHHT3lUSU6JRWK=
MDA-MB-157 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnaTGdwUUN3ME21MlY3PDR|IN88US=> NWj0[HFPW0GQR1XS
NCI-H1623 NFyyOJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzlcllKSzVyPUWuPFM2PTZizszN MlPyV2FPT0WU
RPMI-8866 M1nBcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXYRmRKSzVyPUWuPFQ4QTJizszN NGTkRZlUSU6JRWK=
LC-1F NUXa[5JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInpNXdKSzVyPU[uNFkzQTFizszN NUfBXppsW0GQR1XS
TCCSUP NWLwcm5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDBXJBKSzVyPU[uOlA{PDlizszN NGPCO2pUSU6JRWK=
TT M3G5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\pN3FYUUN3ME24MlM{ODB7IN88US=> MV;TRW5ITVJ?
NCI-H1838 NFjieZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\HcGZKSzVyPUiuOVE4OzFizszN MkLUV2FPT0WU
NCI-H322M NXjoTHNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTlwMU[yPFEh|ryP NWXIc4x[W0GQR1XS
NCI-H187 Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf1fI1KSzVyPUmuOVE5OzVizszN MnfvV2FPT0WU
SBC-1 Mli3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;PN|VKSzVyPUmuPVM3PTZizszN M2XLUXNCVkeHUh?=
SCC-3 NFLxT5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn2TWM2OD1zMD61Olc6KM7:TR?= MkCwV2FPT0WU
SW948 NF\pNIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXnTWM2OD1zMD63OVEyKM7:TR?= MUDTRW5ITVJ?
CPC-N NUGxS5MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jYUmlEPTB;MUGuNFA4KM7:TR?= MmPLV2FPT0WU
TGBC24TKB M176cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTF|LkWyPUDPxE1? NWn4S|ZoW0GQR1XS
NCI-H2452 NULHcYFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr0Z3lKSzVyPUG0Mlc{KM7:TR?= NVLGWmxZW0GQR1XS
Hs-578-T NWWyb|BOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLCV2hKSzVyPUG4MlU4PTlizszN M2XadXNCVkeHUh?=
DV-90 MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF6Lkm5OFUh|ryP MlXvV2FPT0WU
NCI-H1563 NUXleGg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXl[JlKSzVyPUG5Mlc5QDhizszN MoPNV2FPT0WU
SW780 NWLJSZBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\pTpVKSzVyPUKxMlE{OThizszN NUHYPGY{W0GQR1XS
NCI-H345 NYruS4Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzpXGU1UUN3ME2yNU45Pzd7IN88US=> NG[xXHpUSU6JRWK=
LB771-HNC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXSTWM2OD1{Mj60PFE{KM7:TR?= M17S[nNCVkeHUh?=
RT4 NHfT[XlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHlTWM2OD1{Mz6zNlgzKM7:TR?= MY\TRW5ITVJ?
NCI-H82 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3oTWM2OD1{Mz61OVI3KM7:TR?= M1zNWnNCVkeHUh?=
NCI-H524 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3ZS4I6UUN3ME2yOE4{QDF{IN88US=> M{TCR3NCVkeHUh?=
SNU-C1 NHvMbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\4ZVFKSzVyPUK0MlkyODVizszN NYiwXWRqW0GQR1XS
NCI-SNU-16 NGPtXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTR6LkOxOFIh|ryP MmXTV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

細胞アッセイ: [1]

細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

動物実験: [3]

動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
製剤 In DMSO and diluted in sterile saline/Tween 20
投薬量 50 mg/kg
投与方法 Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Luminespib (AUY-922, NVP-AUY922) SDF
分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管 2年-20℃
6月-80℃in solvent
別名 VER-52296
溶解度 (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
エタノール 31 mg/mL (66.58 mM)
<1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

文献中の引用 (23)

技術サポート&よくある質問(FAQ)

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Related HSP (e.g. HSP90) 阻害剤

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  • VER155008

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  • Geldanamycin

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  • HSP990 (NVP-HSP990)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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