Luminespib (AUY-922, NVP-AUY922) 化学構造
分子量: 465.54

高品質保証

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Quality Control & MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野
  • Luminespib (AUY-922, NVP-AUY922)のメカニズム

製品の説明

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。
ターゲット HSP90α HSP90β
IC50 13 nM 21 nM [1]
In vitro試験 NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMK NUjSTWZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXKSoQ5UUN3ME2wMlAxODF{NTFOwG0> MVzTRW5ITVJ?
MV-4-11 M3G1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjtTWM2OD1yLkCwNFU2QCEQvF2= NHnrR2NUSU6JRWK=
NALM-6 NIXwbYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMECwPFQzKM7:TR?= NFLnV2FUSU6JRWK=
HOS M{X4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3XTWM2OD1yLkCwNVM5KM7:TR?= M3nTfHNCVkeHUh?=
HT-144 NEXOZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMECxOVUh|ryP NF7Cb5ZUSU6JRWK=
SW1710 NHnzUlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTxZ|dlUUN3ME2wMlAxOTh4IN88US=> NVj6S4N5W0GQR1XS
TE-8 M{\2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLITWM2OD1yLkCwNlM4KM7:TR?= NX;kdpBiW0GQR1XS
ES1 NIf2S4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LwZmlEPTB;MD6wNFI3PiEQvF2= NUGxVYlIW0GQR1XS
CCF-STTG1 NUT0TlhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O5U2lEPTB;MD6wNFI6PyEQvF2= MlvKV2FPT0WU
PSN1 M3;hPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMECzNVgh|ryP M4D1S3NCVkeHUh?=
CAL-51 Mmi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn35TWM2OD1yLkCwN|I2KM7:TR?= MYPTRW5ITVJ?
MCF7 MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LmfWlEPTB;MD6wNFM{PSEQvF2= Mn\tV2FPT0WU
SK-HEP-1 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXGdmZKSzVyPUCuNFA{OzZizszN M4DiTXNCVkeHUh?=
LCLC-103H MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO2UHZKSzVyPUCuNFA1OyEQvF2= NFTS[JBUSU6JRWK=
HMV-II MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorSTWM2OD1yLkCwOFQ6KM7:TR?= M{n1dXNCVkeHUh?=
MES-SA NF;CeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn6TWM2OD1yLkCwOFUzKM7:TR?= MV7TRW5ITVJ?
SK-LMS-1 M2e3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEC0OVgh|ryP NF7R[XFUSU6JRWK=
639-V MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XJ[WlEPTB;MD6wNFQ5PSEQvF2= NHPWcYxUSU6JRWK=
SIG-M5 NHfRcVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEC0PFkh|ryP NXexPXQ6W0GQR1XS
LOUCY NYH4[41XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPIbFljUUN3ME2wMlAxPTB3IN88US=> NH3EW4xUSU6JRWK=
HSC-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n3fGlEPTB;MD6wNFUyQCEQvF2= NVfCZYNCW0GQR1XS
EW-13 M4LXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEC1NVgh|ryP M3;FT3NCVkeHUh?=
RT-112 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnqPFU3UUN3ME2wMlAxPTN3IN88US=> M3rOPXNCVkeHUh?=
NKM-1 NFjp[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPjTWM2OD1yLkCwOVQ4KM7:TR?= M4LTOHNCVkeHUh?=
KYSE-180 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LwdGlEPTB;MD6wNFU5PiEQvF2= NEXlSWVUSU6JRWK=
SW1783 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTKbo9QUUN3ME2wMlAxPTlzIN88US=> NEDC[HRUSU6JRWK=
A431 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMEC2NFch|ryP M2jHZXNCVkeHUh?=
SK-OV-3 NHi1co1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO4TWM2OD1yLkCwOlMh|ryP NHm0R25USU6JRWK=
RPMI-7951 Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:wVWVKSzVyPUCuNFA3OzFizszN M2XIdHNCVkeHUh?=
Capan-2 NWHhUGtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEC2N|gh|ryP NG\HWmZUSU6JRWK=
HSC-3 NXzIT4dLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\0UXdZUUN3ME2wMlAxPjRzIN88US=> M{jybnNCVkeHUh?=
786-0 M1TaXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfVNo9KSzVyPUCuNFA3PjNizszN MV\TRW5ITVJ?
Daoy MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfCSIVKSzVyPUCuNFA3QTVizszN MnvzV2FPT0WU
KGN MlXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEC3NFMh|ryP MkLFV2FPT0WU
EW-16 NE[3PFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;SWoZKSzVyPUCuNFA4PDlizszN NX\BXnQyW0GQR1XS
EW-7 NU\wVY1kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj1TWM2OD1yLkCwO|U1KM7:TR?= M{S3ZnNCVkeHUh?=
IGROV-1 MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrpTWM2OD1yLkCwPFE1KM7:TR?= NF7QO5ZUSU6JRWK=
8505C MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEC4NlEh|ryP MlvYV2FPT0WU
RKO NIL6XXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorLTWM2OD1yLkCwPFI3KM7:TR?= M3\kW3NCVkeHUh?=
GDM-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEC4OEDPxE1? MWTTRW5ITVJ?
IST-MEL1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEC4OVIh|ryP NGO0TZdUSU6JRWK=
RPMI-6666 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXWTYZKSzVyPUCuNFA5PTJizszN NHjnPI1USU6JRWK=
SNG-M NITudWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS4TWM2OD1yLkCwPFU3KM7:TR?= NIX6PGRUSU6JRWK=
KS-1 NVHZU|RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMEC4OVkh|ryP NV3YfIxjW0GQR1XS
RXF393 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEC4OkDPxE1? M{jjW3NCVkeHUh?=
CAL-12T NIS2SVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7IUIRKSzVyPUCuNFA6OjJizszN MmW4V2FPT0WU
BFTC-905 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\rTWM2OD1yLkCwPVM5KM7:TR?= NXf0SnlpW0GQR1XS
SK-MES-1 NFG5UZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEC5OFUh|ryP Ml3VV2FPT0WU
BB30-HNC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzVfnVKSzVyPUCuNFA6PTJizszN NGqwe|ZUSU6JRWK=
AN3-CA M4jEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3IdItJUUN3ME2wMlAyODF5IN88US=> NInWVm9USU6JRWK=
EFO-27 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEGwNVch|ryP MWXTRW5ITVJ?
G-401 MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vId2lEPTB;MD6wNVAzPSEQvF2= NX;FPGRVW0GQR1XS
BPH-1 NWfQXZppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoD4TWM2OD1yLkCxNFMh|ryP NFroTGNUSU6JRWK=
NCI-H727 NV60T3A{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jDW2lEPTB;MD6wNVA{KM7:TR?= NHrvVoJUSU6JRWK=
SNU-423 MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDVTWN4UUN3ME2wMlAyODV|IN88US=> NU[wb4dlW0GQR1XS
KYSE-270 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn2xTWM2OD1yLkCxNFU6KM7:TR?= NYT4N45YW0GQR1XS
AGS NUH4XFA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTOTWM2OD1yLkCxNFYyKM7:TR?= NWK0d25pW0GQR1XS
NCI-H2228 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzJNVJtUUN3ME2wMlAyODZ2IN88US=> MXnTRW5ITVJ?
SW954 MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEGwO|Eh|ryP M1zTNHNCVkeHUh?=
769-P MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfObYRKSzVyPUCuNFExPzNizszN NVu2dopxW0GQR1XS
BB49-HNC NV6yUFNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEGwO|ch|ryP MoTGV2FPT0WU
IA-LM MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrrXGpKSzVyPUCuNFExQDZizszN M{C4NXNCVkeHUh?=
NB69 M3uyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\1WYVKSzVyPUCuNFEyODJizszN NWfIZlZMW0GQR1XS
C8166 M2XnUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTZTWM2OD1yLkCxNVI6KM7:TR?= M{DNSnNCVkeHUh?=
NCI-H1299 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPzeXJKSzVyPUCuNFEyPTRizszN MVPTRW5ITVJ?
YKG-1 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTWenhxUUN3ME2wMlAyOTZizszN NV2zb5Q5W0GQR1XS
PANC-03-27 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDaZ|lOUUN3ME2wMlAyOTZ{IN88US=> M1LycHNCVkeHUh?=
YT M3XsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnJTWM2OD1yLkCxNVc6KM7:TR?= NXGxXHhnW0GQR1XS
CAL-85-1 MlnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnwb|M2UUN3ME2wMlAyOTl{IN88US=> M{K4NHNCVkeHUh?=
GT3TKB M17MS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\JTWM2OD1yLkCxNlAzKM7:TR?= NYXnW41lW0GQR1XS
BB65-RCC M2LxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHaZ|BXUUN3ME2wMlAyOjB2IN88US=> MmD0V2FPT0WU
ES6 NHPxO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEGyOlEh|ryP M2\1d3NCVkeHUh?=
MHH-ES-1 M3ToPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTaTWM2OD1yLkCxNlY{KM7:TR?= MXzTRW5ITVJ?
QIMR-WIL MoT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEGyOlkh|ryP MWPTRW5ITVJ?
SNU-C2B NGrMTYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HJemlEPTB;MD6wNVI4OiEQvF2= M2XIfnNCVkeHUh?=
OCI-AML2 MknCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHiyfWpKSzVyPUCuNFEzQDFizszN MmjJV2FPT0WU
DU-145 NX35S4hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEGyPUDPxE1? NHn3[IhUSU6JRWK=
SW982 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvH[XdiUUN3ME2wMlAyOjl|IN88US=> MV7TRW5ITVJ?
MFH-ino MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSzemZZUUN3ME2wMlAyOjl|IN88US=> MXXTRW5ITVJ?
A427 MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PJPGlEPTB;MD6wNVI6QSEQvF2= NF;1[2ZUSU6JRWK=
LCLC-97TM1 NEHCeVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DIc2lEPTB;MD6wNVMh|ryP MWDTRW5ITVJ?
AM-38 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmewTWM2OD1yLkCxN|AzKM7:TR?= NFz0b4RUSU6JRWK=
K5 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPBPWVKSzVyPUCuNFE{ODhizszN NVvESop3W0GQR1XS
T84 MlG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD6TWM2OD1yLkCxN|MyKM7:TR?= MmDIV2FPT0WU
TE-15 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vEWWlEPTB;MD6wNVM{PiEQvF2= MVjTRW5ITVJ?
NCI-H460 M2Drdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz5N2hCUUN3ME2wMlAyOzN4IN88US=> NWDVXnRKW0GQR1XS
NTERA-S-cl-D1 MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCxc2FKSzVyPUCuNFE{OzlizszN NFTT[YFUSU6JRWK=
KYSE-450 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrKT3JiUUN3ME2wMlAyOzR7IN88US=> NXfJZYR{W0GQR1XS
H4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NViyTGRIUUN3ME2wMlAyOzZ4IN88US=> NXLab49HW0GQR1XS
LC-2-ad M1XySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzYTWM2OD1yLkCxN|ch|ryP NYCwbWRxW0GQR1XS
GAMG NXLIU2hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGj3epNKSzVyPUCuNFE{PzFizszN MV3TRW5ITVJ?
TK10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFO4RYxKSzVyPUCuNFE{QDJizszN MmLOV2FPT0WU
NCI-H2122 M1fDeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzKTWM2OD1yLkCxN|g1KM7:TR?= NH\qOJVUSU6JRWK=
KM12 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLtTmhGUUN3ME2wMlAyOzl7IN88US=> Mni5V2FPT0WU
CAL-39 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMEG0NkDPxE1? NGDTOW9USU6JRWK=
RPMI-2650 MonQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjOTWM2OD1yLkCxOFMzKM7:TR?= NGHDPJRUSU6JRWK=
KYSE-510 NIPu[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECwUW1KSzVyPUCuNFE1PDJizszN M4jEdHNCVkeHUh?=
KALS-1 NIDQN45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{W4OGlEPTB;MD6wNVQ3PiEQvF2= M1O3UnNCVkeHUh?=
NCI-H1648 Mo\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEG0PVkh|ryP NXzTXm1kW0GQR1XS
ES4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX4TWM2OD1yLkCxOVAzKM7:TR?= NInJcoJUSU6JRWK=
C-33-A NWToS3VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrTXpRKSzVyPUCuNFE2ODlizszN MYTTRW5ITVJ?
MIA-PaCa-2 NHn2cnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP4TWM2OD1yLkCxOVA6KM7:TR?= MVvTRW5ITVJ?
Becker M2\5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEG1NVQh|ryP MVrTRW5ITVJ?
HOP-62 NX7GUIhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvrW|d{UUN3ME2wMlAyPTR{IN88US=> MVXTRW5ITVJ?
TE-1 NVrLRXNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjRT2drUUN3ME2wMlAyPThzIN88US=> MV7TRW5ITVJ?
KYSE-410 NHXGVldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j1U2lEPTB;MD6wNVU5PiEQvF2= M4Pp[nNCVkeHUh?=
NOS-1 Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PFOGlEPTB;MD6wNVU6OyEQvF2= NIHMZYtUSU6JRWK=
MEL-HO NHvYepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPCPIpIUUN3ME2wMlAyPjR|IN88US=> MXPTRW5ITVJ?
NCI-H1650 NGnv[m1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTtTGVbUUN3ME2wMlAyPjR4IN88US=> MX;TRW5ITVJ?
VMRC-RCZ M{LGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXH[nRHUUN3ME2wMlAyPjVzIN88US=> M{DuUXNCVkeHUh?=
HuP-T3 NFH1O3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD5dotKSzVyPUCuNFE3PTNizszN MknQV2FPT0WU
ACN MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{njPGlEPTB;MD6wNVY2PyEQvF2= MVjTRW5ITVJ?
MEL-JUSO MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\STWM2OD1yLkCxOlgyKM7:TR?= NGKySoJUSU6JRWK=
HT-1197 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;BfoVKSzVyPUCuNFE3QDVizszN MoPBV2FPT0WU
NCI-H2030 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXpTWM2OD1yLkCxOlk4KM7:TR?= MlLxV2FPT0WU
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ES8 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXMRXNvUUN3ME2wMlA{PTN6IN88US=> Mnr0V2FPT0WU
KYSE-150 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEO2NFgh|ryP MUDTRW5ITVJ?
HCC1569 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMEO2NFgh|ryP NUHSdXJtW0GQR1XS
NB5 NITMfWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PSdWlEPTB;MD6wN|YyOyEQvF2= MYDTRW5ITVJ?
G-402 NHKzSmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEO2NVQh|ryP NVrWRo1SW0GQR1XS
NCI-H1693 NIDVS5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\EfWlEPTB;MD6wN|YyPyEQvF2= MkexV2FPT0WU
LB2241-RCC Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS1TWM2OD1yLkCzOlQzKM7:TR?= NFOzWIdUSU6JRWK=
KP-4 M4[0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\x[YdtUUN3ME2wMlA{PjZ|IN88US=> Ml3mV2FPT0WU
ML-2 NIHSdHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HaN2lEPTB;MD6wN|Y4OSEQvF2= M3rieHNCVkeHUh?=
KU812 NIHHenRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\SdnVZUUN3ME2wMlA{Pjh2IN88US=> NV7uU3dwW0GQR1XS
LS-411N Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi0NZU3UUN3ME2wMlA{PzNzIN88US=> MknvV2FPT0WU
OAW-42 M3fkRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXVfXJKSzVyPUCuNFM4PDdizszN NVTsVnBwW0GQR1XS
HCC38 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HpNWlEPTB;MD6wN|c4OSEQvF2= NWq0fIxsW0GQR1XS
Ca-Ski M3vQPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4qzOWlEPTB;MD6wN|c5PCEQvF2= MlzVV2FPT0WU
Calu-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDiTWM2OD1yLkCzO|g6KM7:TR?= NVfPTVJSW0GQR1XS
KYSE-70 NETlVW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUC1ZWh2UUN3ME2wMlA{QDF{IN88US=> M17qUXNCVkeHUh?=
D-392MG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMEO4OFIh|ryP NFOzcJpUSU6JRWK=
OVCAR-4 MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjydJY6UUN3ME2wMlA{QDV6IN88US=> NEPMfpRUSU6JRWK=
Detroit562 M1fvW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPiTWM2OD1yLkCzPFczKM7:TR?= NUHaXpplW0GQR1XS
HEL M3;4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEO4PVEh|ryP MkfzV2FPT0WU
MONO-MAC-6 NXHFZVJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEO4PVMh|ryP MU\TRW5ITVJ?
LoVo NH7RVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXLTWM2OD1yLkCzPVM{KM7:TR?= M3XMb3NCVkeHUh?=
U-2-OS MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ftRmlEPTB;MD6wN|k{PSEQvF2= NXTxe21oW0GQR1XS
A172 MkDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEO5OUDPxE1? NFfXbFNUSU6JRWK=
OCUB-M MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHVSVMzUUN3ME2wMlA{QTZzIN88US=> M4PLUHNCVkeHUh?=
SW48 M{XtUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH0TWM2OD1yLkC0NFMyKM7:TR?= MmDlV2FPT0WU
HC-1 NVPtNVV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMESwOlkh|ryP NWr5W2tDW0GQR1XS
KOSC-2 NXrUWlk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWK5NmhuUUN3ME2wMlA1OTFizszN NIrrW5FUSU6JRWK=
HDLM-2 M1TrXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DBXGlEPTB;MD6wOFEyPCEQvF2= NGTSNVJUSU6JRWK=
CTV-1 MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D2PGlEPTB;MD6wOFEyPiEQvF2= MnPTV2FPT0WU
SH-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2myXGlEPTB;MD6wOFE1OSEQvF2= NGPKUYpUSU6JRWK=
SW756 NFLIeJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMESxOVch|ryP M3[5TnNCVkeHUh?=
GCT M4DxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q3fGlEPTB;MD6wOFE3OSEQvF2= Mn;aV2FPT0WU
CHL-1 Mn;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;XW2lEPTB;MD6wOFE3QSEQvF2= M{jmOnNCVkeHUh?=
LAMA-84 MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:yOWhKSzVyPUCuNFQyPzFizszN MUPTRW5ITVJ?
LS-1034 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XQSWlEPTB;MD6wOFE6OSEQvF2= MnKyV2FPT0WU
NCI-H358 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;zTWM2OD1yLkC0NlEzKM7:TR?= MXzTRW5ITVJ?
NB13 M2rZS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2n1R2lEPTB;MD6wOFIzPyEQvF2= MYLTRW5ITVJ?
TE-9 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\Ke2hPUUN3ME2wMlA1OjN5IN88US=> MlTxV2FPT0WU
OE33 M2L6NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHu[mJYUUN3ME2wMlA1OjRzIN88US=> MULTRW5ITVJ?
CAL-120 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnZSmFKSzVyPUCuNFQzPDFizszN NE\rT4NUSU6JRWK=
DJM-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofNTWM2OD1yLkC0NlczKM7:TR?= Mo\zV2FPT0WU
SK-MEL-24 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELT[ItKSzVyPUCuNFQzQDNizszN M2L1NnNCVkeHUh?=
VA-ES-BJ NHmxcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMESyPVIh|ryP M4r0fnNCVkeHUh?=
MMAC-SF MlP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\ZfpdKSzVyPUCuNFQzQTdizszN M1PTPXNCVkeHUh?=
MZ7-mel MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETxOnhKSzVyPUCuNFQ{OyEQvF2= MlzOV2FPT0WU
BxPC-3 NFjUVJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4f5eWlEPTB;MD6wOFM1OSEQvF2= M3fhWXNCVkeHUh?=
HT-29 NWLtWZZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfMNW1KSzVyPUCuNFQ{PTdizszN MXnTRW5ITVJ?
SK-MEL-30 NWrnZnhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPFZ2xKSzVyPUCuNFQ{PjJizszN NHX0WFZUSU6JRWK=
CAL-33 NVzOWppkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;MTWM2OD1yLkC0N|c2KM7:TR?= NUHzNpZXW0GQR1XS
COLO-680N M2TyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TqNWlEPTB;MD6wOFQxPyEQvF2= MXfTRW5ITVJ?
NH-12 M3;ucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPtTWM2OD1yLkC0OFQh|ryP M1uxfXNCVkeHUh?=
HCC1937 NXXwTHhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP2[VVKSzVyPUCuNFQ1PTZizszN NHHLUFNUSU6JRWK=
IMR-5 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMES0PUDPxE1? MkK4V2FPT0WU
MC-CAR M3XIOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfhTWM2OD1yLkC0OVY6KM7:TR?= NUT6[3pNW0GQR1XS
NCI-H747 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkmyTWM2OD1yLkC0OVch|ryP NUXZO3R4W0GQR1XS
NCI-H1792 MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DDemlEPTB;MD6wOFU5OSEQvF2= NFLKWGxUSU6JRWK=
SW13 NWn5SplET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X4[mlEPTB;MD6wOFU6KM7:TR?= M13TTHNCVkeHUh?=
MLMA MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHPNHNKSzVyPUCuNFQ3ODlizszN M3PCbnNCVkeHUh?=
U251 M{C0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\6UZFiUUN3ME2wMlA1PzZ|IN88US=> NVzBPWprW0GQR1XS
U031 M4\HS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK1TWM2OD1yLkC0O|cyKM7:TR?= NXrT[XBZW0GQR1XS
ME-180 M1;wRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMES3PFIh|ryP Mn2wV2FPT0WU
SK-MEL-3 MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljDTWM2OD1yLkC0PFAzKM7:TR?= MUHTRW5ITVJ?
MOLT-4 NIHYNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLtUWxXUUN3ME2wMlA1QDB|IN88US=> MWHTRW5ITVJ?
PF-382 NX;3dnZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTVTWM2OD1yLkC0PFI3KM7:TR?= MULTRW5ITVJ?
NUGC-3 NWXlWoZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW3fI01UUN3ME2wMlA1QDJ5IN88US=> MUjTRW5ITVJ?
NCI-H1417 NIq3S3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXxVpNKSzVyPUCuNFQ5QSEQvF2= MlLVV2FPT0WU
COLO-205 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj5W3ZKSzVyPUCuNFQ6OTlizszN NGLleHlUSU6JRWK=
TE-441-T NXLpOW9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMES5N{DPxE1? NHnTZVVUSU6JRWK=
MKN1 M{HiOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;PZ2lEPTB;MD6wOFk{KM7:TR?= NFzxZ3dUSU6JRWK=
UM-UC-3 M3fCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXDTWM2OD1yLkC0PVUh|ryP MnPLV2FPT0WU
SF126 NFPGNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nIOGlEPTB;MD6wOVAyKM7:TR?= NELP[nBUSU6JRWK=
LB1047-RCC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXIXYlKSzVyPUCuNFUxOzFizszN MoXQV2FPT0WU
A253 MkH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PLWmlEPTB;MD6wOVA2OiEQvF2= MXXTRW5ITVJ?
NCI-H1963 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXOXHVKSzVyPUCuNFUyPzZizszN MlzzV2FPT0WU
VM-CUB-1 NFv3SZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLxOJdKSzVyPUCuNFU{OTFizszN MX3TRW5ITVJ?
T-24 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\4Z5prUUN3ME2wMlA2Ozh2IN88US=> NGDnRY5USU6JRWK=
K-562 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i1ZWlEPTB;MD6wOVM5PyEQvF2= M1r5[nNCVkeHUh?=
ARH-77 M3zrN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T4U2lEPTB;MD6wOVM6PSEQvF2= Mn;jV2FPT0WU
CA46 NWfVfWVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPNTWM2OD1yLkC1OFMh|ryP MlzVV2FPT0WU
HCC70 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEW0OVIh|ryP MU\TRW5ITVJ?
ST486 NVL1S5ljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nRWGlEPTB;MD6wOVUzPSEQvF2= M3jOWnNCVkeHUh?=
COLO-741 NY\GWolYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTBUGJ6UUN3ME2wMlA2PTNzIN88US=> MonMV2FPT0WU
SK-PN-DW NFPQPZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTnTWM2OD1yLkC1OVg5KM7:TR?= MYjTRW5ITVJ?
BL-41 NIn1O5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEW1PVYh|ryP NFzHd5JUSU6JRWK=
D-263MG NYDKXJJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlraTWM2OD1yLkC1Olg{KM7:TR?= NH75OWZUSU6JRWK=
KE-37 NGTxcFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMEW2PFMh|ryP MmOwV2FPT0WU
LU-134-A MnLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G3TGlEPTB;MD6wOVcyPSEQvF2= Mn\BV2FPT0WU
HCC2157 NVHEVYNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfxfWtKSzVyPUCuNFU4OzNizszN M4\TdHNCVkeHUh?=
GAK NFTRRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEW3N|Qh|ryP NIK0PG9USU6JRWK=
IST-SL2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXaT2JMUUN3ME2wMlA2PzR|IN88US=> NHXpOJpUSU6JRWK=
KMOE-2 NXGzbJdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrwUpRYUUN3ME2wMlA2PzR7IN88US=> NVTuZ|JGW0GQR1XS
SW1573 NXf1NWZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Xhd2lEPTB;MD6wOVgxOiEQvF2= M3nGeHNCVkeHUh?=
SCC-9 Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3mxT2lEPTB;MD6wOVg4KM7:TR?= MmHlV2FPT0WU
MDA-MB-361 MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPhTWM2OD1yLkC1PFczKM7:TR?= MYnTRW5ITVJ?
BHT-101 M2\qc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEW4O|Yh|ryP M1PPWnNCVkeHUh?=
NCI-H1770 NFHyXFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEW4O|kh|ryP NWi2fWZlW0GQR1XS
UACC-893 M4LBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mor6TWM2OD1yLkC1PFk3KM7:TR?= M2XWPHNCVkeHUh?=
NCI-H226 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\0cIJKSzVyPUCuNFU6QDhizszN M{nobHNCVkeHUh?=
HLE MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;YNpQ4UUN3ME2wMlA3ODh{IN88US=> MWPTRW5ITVJ?
NCI-H1703 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHGUpN2UUN3ME2wMlA3OTd6IN88US=> MVnTRW5ITVJ?
KURAMOCHI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\0eJZCUUN3ME2wMlA3OTh7IN88US=> MkDxV2FPT0WU
RH-1 NGf4OXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\oXWFKSzVyPUCuNFYzOyEQvF2= NI[3WldUSU6JRWK=
DSH1 M{[0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrOSHVKSzVyPUCuNFYzPyEQvF2= NXXRW45yW0GQR1XS
CAMA-1 M1PyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\TNHZyUUN3ME2wMlA3OzB|IN88US=> MoC4V2FPT0WU
NCI-H1437 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwME[zNlgh|ryP NXjwWmtEW0GQR1XS
HuP-T4 M1PkOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHqzRZNKSzVyPUCuNFY2QDZizszN M3LYUHNCVkeHUh?=
HCT-15 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG3UpNKSzVyPUCuNFY2QTdizszN MUHTRW5ITVJ?
NCCIT MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwME[2NFQh|ryP NVPHWph3W0GQR1XS
BOKU NFXMXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PXZmlEPTB;MD6wOlY4PCEQvF2= Mmi0V2FPT0WU
FADU NVv6Zo9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzVXXRXUUN3ME2wMlA3PzR3IN88US=> MXjTRW5ITVJ?
SUP-T1 NGjjOHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPmOWdKSzVyPUCuNFY4PiEQvF2= M2PEOHNCVkeHUh?=
L-363 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jpc2lEPTB;MD6wOlkxOSEQvF2= MlvEV2FPT0WU
KNS-81-FD NYXOS5lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG2WGRKSzVyPUCuNFY6OThizszN NIHDeHRUSU6JRWK=
SU-DHL-1 NXjobZpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwME[5NkDPxE1? NVPlV5VzW0GQR1XS
HuH-7 NWP1PJhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TKe2lEPTB;MD6wO|A{PSEQvF2= MXrTRW5ITVJ?
BT-474 NYDCZWhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fXbGlEPTB;MD6wO|A3OSEQvF2= Ml7SV2FPT0WU
CAPAN-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEexOFMh|ryP MVzTRW5ITVJ?
HEC-1 NGPGdnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnWxTWM2OD1yLkC3NVYyKM7:TR?= M1L4O3NCVkeHUh?=
NOMO-1 NYnPXIo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLHb3ZKSzVyPUCuNFcyPzJizszN M1\hcHNCVkeHUh?=
KM-H2 MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M16zWmlEPTB;MD6wO|I1OSEQvF2= NXq2T2V[W0GQR1XS
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NCI-H2171 NF3jN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zBfGlEPTB;MD6xPFY1QSEQvF2= MYTTRW5ITVJ?
NCI-H526 M{DQUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrUTWM2OD1yLkG4Olk3KM7:TR?= MmDpV2FPT0WU
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LU-65 MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfQXXhwUUN3ME2wMlIxOjFzIN88US=> MUnTRW5ITVJ?
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NCI-H2196 MnfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMkG3OFch|ryP Mmn0V2FPT0WU
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NCI-H838 Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMkO3NVQh|ryP NIjGfGNUSU6JRWK=
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BT-20 M2q5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm2RlI1UUN3ME2wMlMyODl7IN88US=> M1jzWXNCVkeHUh?=
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NCI-H1882 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfZd5RFUUN3ME2wMlQyPzh2IN88US=> MVPTRW5ITVJ?
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NCI-H716 NHPFVJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwNES4OFgh|ryP MUDTRW5ITVJ?
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RPMI-8402 NIDtdHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DvbWlEPTB;MD61NlIxPyEQvF2= M3v1RXNCVkeHUh?=
SW1088 NVHWTHloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPXeJpVUUN3ME2wMlU{QDZ7IN88US=> NYjFV5hUW0GQR1XS
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NCI-H2126 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfyOmczUUN3ME2wMlY{OTV{IN88US=> MonCV2FPT0WU
HCC1954 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEC0R5lKSzVyPUCuOlQ4OjZizszN NUWxU2RsW0GQR1XS
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TYK-nu NHPi[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrLTWM2OD1yLk[3PVUzKM7:TR?= NIHUVXFUSU6JRWK=
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SIMA Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3yzUGlEPTB;MD63NVcyQSEQvF2= Mmn4V2FPT0WU
RCC10RGB NGrBW49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fpc2lEPTB;MD63NVkyQCEQvF2= MnfUV2FPT0WU
LN-405 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Kxd2lEPTB;MD63OFM3KM7:TR?= MUnTRW5ITVJ?
NCI-H1155 M1XGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvOTWM2OD1yLke0PFY5KM7:TR?= M4q1fXNCVkeHUh?=
SCLC-21H NW\LbIhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\mTWM2OD1yLke2PVA{KM7:TR?= MmnqV2FPT0WU
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EC-GI-10 M3vEPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTXUWd6UUN3ME2wMlc4QTd3IN88US=> MlXPV2FPT0WU
KNS-42 NH\ncYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfq[Y0zUUN3ME2wMlc5QDNzIN88US=> NXPhXVl[W0GQR1XS
SNU-475 Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rpVmlEPTB;MD63PVIxOiEQvF2= NYHybo83W0GQR1XS
SF539 NX7sUpJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXDPGtTUUN3ME2wMlc6QTJ3IN88US=> M3LUNHNCVkeHUh?=
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ATN-1 M{jOV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvKXWRLUUN3ME2wMlg2OTF3IN88US=> NHnTfZBUSU6JRWK=
PLC-PRF-5 M{DtO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D2TWlEPTB;MD64PFQ4PSEQvF2= MoTVV2FPT0WU
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MDA-MB-453 NH[w[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nYXmlEPTB;MD65NFMxPCEQvF2= Mnz1V2FPT0WU
HAL-01 NX\tbmhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwOUmzO|kh|ryP M1vDSXNCVkeHUh?=
NCI-H1993 NIS0TYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFwMES2OVch|ryP MUfTRW5ITVJ?
NCI-H2227 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\RNmlEPTB;MT6wOFk5OSEQvF2= Mkf6V2FPT0WU
LP-1 Mn:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjWTWM2OD1zLkC2PVMh|ryP NWq3b41yW0GQR1XS
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NCI-H64 MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS0WlAxUUN3ME2xMlE2PDJizszN NHLYPJdUSU6JRWK=
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TALL-1 MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXpVpl6UUN3ME2xMlI2OTZ3IN88US=> NEiyUoxUSU6JRWK=
RO82-W-1 NFO0XGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXn2fGxDUUN3ME2xMlM{OzN7IN88US=> NXPaOZU2W0GQR1XS
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NCI-H748 M2C3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\nd3pKSzVyPUGuN|U4OzhizszN NETQNnhUSU6JRWK=
HCC1187 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTuO5FrUUN3ME2xMlU2PTJ{IN88US=> NGTpN|FUSU6JRWK=
EoL-1-cell NYX5e3p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwNUi4PFkh|ryP M4X3bnNCVkeHUh?=
HuO-3N1 M1K2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIW2SVFKSzVyPUGuPFM1OTJizszN MXTTRW5ITVJ?
NCI-H1793 NFvBc2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTZR4lmUUN3ME2xMlg4PTl|IN88US=> MXLTRW5ITVJ?
Caov-3 NGDIVlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS5TWM2OD1{LkCwOlI2KM7:TR?= NHXDOllUSU6JRWK=
JAR NH3OXG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjLZVFzUUN3ME2yMlA4QTJizszN MUPTRW5ITVJ?
SK-MEL-28 NIK5PFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rhW2lEPTB;Mj6xPFA6QCEQvF2= NULBd|FEW0GQR1XS
EM-2 M4nXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPrSmRiUUN3ME2yMlIxOjl|IN88US=> M4LZcHNCVkeHUh?=
Mewo MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS4fVl3UUN3ME2yMlIzOjZ3IN88US=> MlfEV2FPT0WU
NCI-H720 NEi4eYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJwMk[1PFUh|ryP NVjjbolCW0GQR1XS
CAL-54 NEHs[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XKTWlEPTB;Mj6yOlc6PSEQvF2= MV3TRW5ITVJ?
MC116 MnjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q0RmlEPTB;Mj6zOlM6PyEQvF2= Mn\MV2FPT0WU
DG-75 NVO0R|ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJwNEi1O|Yh|ryP M3jiNnNCVkeHUh?=
HCC1143 NVLSZYxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\VU2lEPTB;Mj61NFY2QCEQvF2= M1H0XXNCVkeHUh?=
FTC-133 M2PtPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv3ToNoUUN3ME2yMlU{Pjh7IN88US=> NYH5cZplW0GQR1XS
AsPC-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHoPJhKSzVyPUKuOVM6OjlizszN NFSxcIpUSU6JRWK=
NCI-H889 NHLT[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJwNU[3NFYh|ryP MUHTRW5ITVJ?
HT55 M4G5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfxc2pKSzVyPUKuOlIxOTlizszN MorYV2FPT0WU
UMC-11 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHOWIVKSzVyPUKuO|g4OTVizszN NWP1dlFnW0GQR1XS
P12-ICHIKAWA NIjnRldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTJwOEKwOFYh|ryP M1TtSnNCVkeHUh?=
HCC1395 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJwOUi2NFIh|ryP MYjTRW5ITVJ?
D-283MED M3vk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNwMUi5N|ch|ryP NHf6fZZUSU6JRWK=
COLO-800 M{DseGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHqOGw{UUN3ME2zMlM{QDl5IN88US=> MXjTRW5ITVJ?
MFM-223 MlHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj0dWFKSzVyPUOuN|YxQTdizszN MYDTRW5ITVJ?
TE-5 M2PZbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi1bXRpUUN3ME20MlU3OTR5IN88US=> MlrKV2FPT0WU
NCI-H209 MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;iU2lEPTB;ND63PFU4OiEQvF2= NHHRXGFUSU6JRWK=
SiHa MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XBRWlEPTB;ND65OVIxOyEQvF2= MUjTRW5ITVJ?
NCI-H1395 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTVwMUC2N|Mh|ryP MmfLV2FPT0WU
A498 M{PpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXxWGtYUUN3ME21MlIyOjVzIN88US=> NUHvRox6W0GQR1XS
ES5 MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTVwNkGxO|gh|ryP MXPTRW5ITVJ?
MDA-MB-157 NGrjPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTVwNk[0OFMh|ryP NX3XT2lnW0GQR1XS
NCI-H1623 NVPLV|RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\ZTWlEPTB;NT64N|U2PiEQvF2= MnzGV2FPT0WU
RPMI-8866 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTVwOES3PVIh|ryP NGnvVXBUSU6JRWK=
LC-1F NYXQNI04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nDemlEPTB;Nj6wPVI6OSEQvF2= MXXTRW5ITVJ?
TCCSUP MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4S1SGlEPTB;Nj62NFM1QSEQvF2= MULTRW5ITVJ?
TT NH:wbYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDab41KSzVyPUiuN|MxODlizszN NUXsS|VlW0GQR1XS
NCI-H1838 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\pTWM2OD16LkWxO|MyKM7:TR?= M2HlenNCVkeHUh?=
NCI-H322M M2TlVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLCTWM2OD17LkG2NlgyKM7:TR?= MoDoV2FPT0WU
NCI-H187 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3q0fGlEPTB;OT61NVg{PSEQvF2= Mn3CV2FPT0WU
SBC-1 MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PVTmlEPTB;OT65N|Y2PiEQvF2= MX\TRW5ITVJ?
SCC-3 NXXMZVl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTtTWM2OD1zMD61Olc6KM7:TR?= MXPTRW5ITVJ?
SW948 MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\B[WFKSzVyPUGwMlc2OTFizszN Mk\BV2FPT0WU
CPC-N M33EfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS3cZZKSzVyPUGxMlAxPyEQvF2= M33N[XNCVkeHUh?=
TGBC24TKB MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO2bG5KSzVyPUGzMlUzQSEQvF2= NWn0[ZBJW0GQR1XS
NCI-H2452 NFXx[JlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\BfFl3UUN3ME2xOE44OyEQvF2= NYrvTGE1W0GQR1XS
Hs-578-T NX:wV5hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHxcm5KSzVyPUG4MlU4PTlizszN NEjIV2lUSU6JRWK=
DV-90 NUHQNpZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv6TWM2OD1zOD65PVQ2KM7:TR?= M{T3SXNCVkeHUh?=
NCI-H1563 M3S0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\EZ4dKSzVyPUG5Mlc5QDhizszN MlPVV2FPT0WU
SW780 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33lcWlEPTB;MkGuNVMyQCEQvF2= NGCyUoNUSU6JRWK=
NCI-H345 NYLDWXU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjZTWM2OD1{MT64O|c6KM7:TR?= MXnTRW5ITVJ?
LB771-HNC M{DwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWizd2lvUUN3ME2yNk41QDF|IN88US=> MojSV2FPT0WU
RT4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXWyPFhVUUN3ME2yN{4{Ojh{IN88US=> M{iycnNCVkeHUh?=
NCI-H82 NFrC[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFyzfZlKSzVyPUKzMlU2OjZizszN NGq4UFVUSU6JRWK=
NCI-H524 MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu4e|RvUUN3ME2yOE4{QDF{IN88US=> Mlz6V2FPT0WU
SNU-C1 NWXkfFlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjYTWM2OD1{ND65NVA2KM7:TR?= MYjTRW5ITVJ?
NCI-SNU-16 M{nYUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTR6LkOxOFIh|ryP Ml\rV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

細胞アッセイ: [1]

細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

動物実験: [3]

動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
製剤 In DMSO and diluted in sterile saline/Tween 20
投薬量 50 mg/kg
投与方法 Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Luminespib (AUY-922, NVP-AUY922) SDF
分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管 2年-20℃
6月-80℃in solvent
別名 VER-52296
溶解度 (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
エタノール 31 mg/mL (66.58 mM)
<1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

文献中の引用 (23)

技術サポート&よくある質問(FAQ)

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* 必須

Related HSP (e.g. HSP90) 阻害剤

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    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.

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  • VER155008

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  • Geldanamycin

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  • HSP990 (NVP-HSP990)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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