Luminespib (AUY-922, NVP-AUY922) 化学構造
分子量: 465.54

高品質保証

カスタマーフィードバック(3)

MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野
  • Luminespib (AUY-922, NVP-AUY922)のメカニズム

製品の説明

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。
ターゲット HSP90α HSP90β
IC50 13 nM 21 nM [1]
In vitro試験 NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMK M4XJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3kTWM2OD1yLkCwNFEzPSEQvF2= MXLTRW5ITVJ?
MV-4-11 NVjUNHhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnYTWM2OD1yLkCwNFU2QCEQvF2= NX:zVIRtW0GQR1XS
NALM-6 NIP6SlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP3bJA2UUN3ME2wMlAxODh2MjFOwG0> NH\KfGxUSU6JRWK=
HOS NYi4Zo5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrNTWM2OD1yLkCwNVM5KM7:TR?= Ml62V2FPT0WU
HT-144 NEXRPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXpTWM2OD1yLkCwNVU2KM7:TR?= M2TF[XNCVkeHUh?=
SW1710 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMECxPFYh|ryP MV;TRW5ITVJ?
TE-8 M4nPO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1f0fWlEPTB;MD6wNFI{PyEQvF2= M4\wVnNCVkeHUh?=
ES1 Mn;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LEOWlEPTB;MD6wNFI3PiEQvF2= MWPTRW5ITVJ?
CCF-STTG1 M3PSUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP4XllWUUN3ME2wMlAxOjl5IN88US=> MnT4V2FPT0WU
PSN1 M4L2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;JTWM2OD1yLkCwN|E5KM7:TR?= MonDV2FPT0WU
CAL-51 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfqTWM2OD1yLkCwN|I2KM7:TR?= MmnpV2FPT0WU
MCF7 M1;hb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMECzN|Uh|ryP M4DUNXNCVkeHUh?=
SK-HEP-1 Mmr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfzTWM2OD1yLkCwN|M3KM7:TR?= MoPLV2FPT0WU
LCLC-103H NXTzdItQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjSVIdKSzVyPUCuNFA1OyEQvF2= Mm\1V2FPT0WU
HMV-II MmPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vsZ2lEPTB;MD6wNFQ1QSEQvF2= MlH2V2FPT0WU
MES-SA NVHPXXp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrkUmlKSzVyPUCuNFA1PTJizszN NV3mdnIyW0GQR1XS
SK-LMS-1 NXfzelR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3PfZBKSzVyPUCuNFA1PThizszN MXvTRW5ITVJ?
639-V NIDH[mtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{npTWlEPTB;MD6wNFQ5PSEQvF2= NHq0NnFUSU6JRWK=
SIG-M5 NHnJTJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDMR5hKSzVyPUCuNFA1QDlizszN MWPTRW5ITVJ?
LOUCY NVvvSHNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEC1NFUh|ryP NH;CfohUSU6JRWK=
HSC-2 NXnF[HlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPqTWM2OD1yLkCwOVE5KM7:TR?= MUfTRW5ITVJ?
EW-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TFUWlEPTB;MD6wNFUyQCEQvF2= NWPPXJlpW0GQR1XS
RT-112 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXLSmxKSzVyPUCuNFA2OzVizszN NVq3WVV5W0GQR1XS
NKM-1 M{nkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTlRm9KSzVyPUCuNFA2PDdizszN NUPLPFZGW0GQR1XS
KYSE-180 MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mke4TWM2OD1yLkCwOVg3KM7:TR?= NEPGXG9USU6JRWK=
SW1783 MlWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3qzW2lEPTB;MD6wNFU6OSEQvF2= NVP6N4xWW0GQR1XS
A431 NXn4NnlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTOTWM2OD1yLkCwOlA4KM7:TR?= NITzT5pUSU6JRWK=
SK-OV-3 MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zGVGlEPTB;MD6wNFY{KM7:TR?= M{XzbXNCVkeHUh?=
RPMI-7951 NXftPZZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG5NGNKSzVyPUCuNFA3OzFizszN MVfTRW5ITVJ?
Capan-2 NYm3e45LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\FUplKSzVyPUCuNFA3OzhizszN Ml;BV2FPT0WU
HSC-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfxZ2ZKSzVyPUCuNFA3PDFizszN MoDCV2FPT0WU
786-0 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP3Wm1zUUN3ME2wMlAxPjZ|IN88US=> NFfxRYRUSU6JRWK=
Daoy M37IUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Lse2lEPTB;MD6wNFY6PSEQvF2= MWnTRW5ITVJ?
KGN Moi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEC3NFMh|ryP MmqxV2FPT0WU
EW-16 NF3TbJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlWxTWM2OD1yLkCwO|Q6KM7:TR?= M2\OVXNCVkeHUh?=
EW-7 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7qTWM2OD1yLkCwO|U1KM7:TR?= M33HPHNCVkeHUh?=
IGROV-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHtTotkUUN3ME2wMlAxQDF2IN88US=> M4LWOXNCVkeHUh?=
8505C NYHD[|VlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHriSmZKSzVyPUCuNFA5OjFizszN MoD6V2FPT0WU
RKO NUDZSo5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnhTWM2OD1yLkCwPFI3KM7:TR?= M4HwRnNCVkeHUh?=
GDM-1 NYf1VWt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEC4OEDPxE1? NYHjcllHW0GQR1XS
IST-MEL1 NGLQWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M170XmlEPTB;MD6wNFg2OiEQvF2= M3X3OHNCVkeHUh?=
RPMI-6666 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XRcGlEPTB;MD6wNFg2OiEQvF2= NX7JOnpPW0GQR1XS
SNG-M MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TtVmlEPTB;MD6wNFg2PiEQvF2= NVzzWGVNW0GQR1XS
KS-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHLTXpzUUN3ME2wMlAxQDV7IN88US=> M33jXXNCVkeHUh?=
RXF393 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;acXFKSzVyPUCuNFA5PiEQvF2= MU\TRW5ITVJ?
CAL-12T NFr6N2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMEC5NlIh|ryP M2PzOnNCVkeHUh?=
BFTC-905 NIjvPZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnPTWM2OD1yLkCwPVM5KM7:TR?= NEDwXohUSU6JRWK=
SK-MES-1 NX7OSmRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXWxUXVNUUN3ME2wMlAxQTR3IN88US=> MmTpV2FPT0WU
BB30-HNC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\JRmlEPTB;MD6wNFk2OiEQvF2= M4nlS3NCVkeHUh?=
AN3-CA NHLLW5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Xy[GlEPTB;MD6wNVAyPyEQvF2= Ml3NV2FPT0WU
EFO-27 NWPHSG8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDtR4tKSzVyPUCuNFExOTdizszN MkXMV2FPT0WU
G-401 Mmm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDWWYVHUUN3ME2wMlAyODJ3IN88US=> Mo\NV2FPT0WU
BPH-1 NWL0T4hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f5RWlEPTB;MD6wNVA{KM7:TR?= Mo\RV2FPT0WU
NCI-H727 NYPIPYFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfKZmZKSzVyPUCuNFExOyEQvF2= M3vs[nNCVkeHUh?=
SNU-423 NETwfGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jVOGlEPTB;MD6wNVA2OyEQvF2= MmHFV2FPT0WU
KYSE-270 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESxe5FKSzVyPUCuNFExPTlizszN Mmm3V2FPT0WU
AGS M4PMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMEGwOlEh|ryP Mm\IV2FPT0WU
NCI-H2228 NF34UnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLJOpUzUUN3ME2wMlAyODZ2IN88US=> MVfTRW5ITVJ?
SW954 NWHLNpB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr6XYJKSzVyPUCuNFExPzFizszN NFj6eJNUSU6JRWK=
769-P NH\1SoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEGwO|Mh|ryP NUn3fm5IW0GQR1XS
BB49-HNC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[zdlVKSzVyPUCuNFExPzdizszN NILBTIVUSU6JRWK=
IA-LM MnPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnBVWxKSzVyPUCuNFExQDZizszN NGTDOFlUSU6JRWK=
NB69 NXfodnJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPN[pFKSzVyPUCuNFEyODJizszN M1XLWXNCVkeHUh?=
C8166 MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEGxNlkh|ryP NH\aTGxUSU6JRWK=
NCI-H1299 NVXNdVdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jNZmlEPTB;MD6wNVE2PCEQvF2= Mk\PV2FPT0WU
YKG-1 M{DJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrQdpRKSzVyPUCuNFEyPiEQvF2= Ml:4V2FPT0WU
PANC-03-27 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDVTWM2OD1yLkCxNVYzKM7:TR?= NEjGOIVUSU6JRWK=
YT Mo\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEGxO|kh|ryP NFrTdFhUSU6JRWK=
CAL-85-1 M{nxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rz[2lEPTB;MD6wNVE6OiEQvF2= MWHTRW5ITVJ?
GT3TKB NGTXfY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrOTWM2OD1yLkCxNlAzKM7:TR?= NH7qUFhUSU6JRWK=
BB65-RCC MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEGyNFQh|ryP MWrTRW5ITVJ?
ES6 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDMcXFKSzVyPUCuNFEzPjFizszN NILCblhUSU6JRWK=
MHH-ES-1 MmPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rjdmlEPTB;MD6wNVI3OyEQvF2= NX\FRYcyW0GQR1XS
QIMR-WIL NYjrSI5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMEGyOlkh|ryP MnPSV2FPT0WU
SNU-C2B NVP3NYNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEGyO|Ih|ryP MkjmV2FPT0WU
OCI-AML2 NFThfHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHIS2JJUUN3ME2wMlAyOjhzIN88US=> NVLSRlMzW0GQR1XS
DU-145 MoHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3WyU2lEPTB;MD6wNVI6KM7:TR?= M33CU3NCVkeHUh?=
SW982 M3W4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXjZ41qUUN3ME2wMlAyOjl|IN88US=> NXz3W5AzW0GQR1XS
MFH-ino NUjpOVd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEGyPVMh|ryP M3;tUXNCVkeHUh?=
A427 NHnWTpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEGyPVkh|ryP NE\aSIdUSU6JRWK=
LCLC-97TM1 Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVSxcGhrUUN3ME2wMlAyOyEQvF2= NYjOTVFoW0GQR1XS
AM-38 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXG5W5N1UUN3ME2wMlAyOzB{IN88US=> MUfTRW5ITVJ?
K5 NYXUOGhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P6OGlEPTB;MD6wNVMxQCEQvF2= NGmwT3hUSU6JRWK=
T84 Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT2Z4dKSzVyPUCuNFE{OzFizszN NVnZeoxYW0GQR1XS
TE-15 NF;OXnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzrTWM2OD1yLkCxN|M3KM7:TR?= Ml7DV2FPT0WU
NCI-H460 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPOdYVtUUN3ME2wMlAyOzN4IN88US=> MnG2V2FPT0WU
NTERA-S-cl-D1 NITrWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HTbmlEPTB;MD6wNVM{QSEQvF2= M{DvdXNCVkeHUh?=
KYSE-450 NVLiU|J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWW5PFNPUUN3ME2wMlAyOzR7IN88US=> MUPTRW5ITVJ?
H4 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEGzOlYh|ryP NU[xSIgxW0GQR1XS
LC-2-ad NIXxOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S3NGlEPTB;MD6wNVM4KM7:TR?= NF6xVXJUSU6JRWK=
GAMG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMEGzO|Eh|ryP MUnTRW5ITVJ?
TK10 M2LJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEGzPFIh|ryP M1z6[XNCVkeHUh?=
NCI-H2122 M{jsUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWCwS3FSUUN3ME2wMlAyOzh2IN88US=> MlPOV2FPT0WU
KM12 NFzmcIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEGzPVkh|ryP M3nCOXNCVkeHUh?=
CAL-39 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDT[nVTUUN3ME2wMlAyPDJizszN MnzSV2FPT0WU
RPMI-2650 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMEG0N|Ih|ryP M{XCNHNCVkeHUh?=
KYSE-510 NIH4d45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHZd2VKSzVyPUCuNFE1PDJizszN M3fRcnNCVkeHUh?=
KALS-1 MnjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEG0OlYh|ryP MkniV2FPT0WU
NCI-H1648 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfCTWM2OD1yLkCxOFk6KM7:TR?= MV7TRW5ITVJ?
ES4 NH7r[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrLXYNFUUN3ME2wMlAyPTB{IN88US=> NEXrTZRUSU6JRWK=
C-33-A MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEG1NFkh|ryP Mn\sV2FPT0WU
MIA-PaCa-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEG1NFkh|ryP MnjzV2FPT0WU
Becker NVTURYJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMEG1NVQh|ryP M4fpOXNCVkeHUh?=
HOP-62 NYPuXIdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEG1OFIh|ryP MXrTRW5ITVJ?
TE-1 NYr0SmZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHWTWM2OD1yLkCxOVgyKM7:TR?= Mly5V2FPT0WU
KYSE-410 NF2xZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEG1PFYh|ryP MUDTRW5ITVJ?
NOS-1 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTNTWM2OD1yLkCxOVk{KM7:TR?= MWLTRW5ITVJ?
MEL-HO NEfhNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTlWIpKSzVyPUCuNFE3PDNizszN M2HLcHNCVkeHUh?=
NCI-H1650 NEHQSFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3lVphKSzVyPUCuNFE3PDZizszN NYPiZpZXW0GQR1XS
VMRC-RCZ MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEG2OVEh|ryP NYXHV3NHW0GQR1XS
HuP-T3 NVHjSXdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jNTmlEPTB;MD6wNVY2OyEQvF2= M3zrbXNCVkeHUh?=
ACN NHrpdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMEG2OVch|ryP MUXTRW5ITVJ?
MEL-JUSO M4HWeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\NfW1TUUN3ME2wMlAyPjhzIN88US=> NIK2codUSU6JRWK=
HT-1197 NX\oW5loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHVUmpYUUN3ME2wMlAyPjh3IN88US=> MojPV2FPT0WU
NCI-H2030 NIT3WnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDBTWM2OD1yLkCxOlk4KM7:TR?= NILnOHhUSU6JRWK=
A4-Fuk MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLzNWRKSzVyPUCuNFE4ODJizszN MlO2V2FPT0WU
NCI-H292 MnHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXacWNSUUN3ME2wMlAyPzB7IN88US=> MYjTRW5ITVJ?
A2780 NWPpdJZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDLVVVbUUN3ME2wMlAyPzF3IN88US=> Mkf3V2FPT0WU
SF295 NGL4NllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPXbZZDUUN3ME2wMlAyPzJzIN88US=> Ml3mV2FPT0WU
NCI-H810 NVHEVXJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrVXJRKSzVyPUCuNFE4OjRizszN MVHTRW5ITVJ?
ALL-PO MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zuXWlEPTB;MD6wNVc{PSEQvF2= NYDxe5oyW0GQR1XS
MC-IXC Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D6fWlEPTB;MD6wNVc{PiEQvF2= MXjTRW5ITVJ?
NY NXfTdJJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEG3OEDPxE1? M2\3UXNCVkeHUh?=
OMC-1 Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLj[m9iUUN3ME2wMlAyPzVzIN88US=> MUHTRW5ITVJ?
PANC-10-05 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMEG3OVUh|ryP NX:yb3RRW0GQR1XS
NCI-H2342 NHLydIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7CTWM2OD1yLkCxO|U5KM7:TR?= MkD6V2FPT0WU
HGC-27 NEnsXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlWyTWM2OD1yLkCxO|U5KM7:TR?= NEPEOXRUSU6JRWK=
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MOLT-16 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEG3PFgh|ryP NIXGUIJUSU6JRWK=
HL-60 NVHEboR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEG4NFch|ryP MlTaV2FPT0WU
OVCAR-5 M1rL[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEG4NVIh|ryP NUfW[|BpW0GQR1XS
SK-LU-1 NVi4cWdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn6NFlKSzVyPUCuNFE5PDZizszN MV3TRW5ITVJ?
MG-63 NIjpWHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LDcWlEPTB;MD6wNVg4PCEQvF2= M1zuSXNCVkeHUh?=
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COR-L105 NYnXWnVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzBTWM2OD1yLkCxPVEyKM7:TR?= NUO5Ro5NW0GQR1XS
BHY MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\4fotwUUN3ME2wMlAyQTF{IN88US=> M1:2S3NCVkeHUh?=
SW620 NVTJNJpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jHXmlEPTB;MD6wNVkyPSEQvF2= Mnv2V2FPT0WU
PC-14 NX3B[JBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMEG5N|Qh|ryP NEn1bIdUSU6JRWK=
NCI-H522 NILjXWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli2TWM2OD1yLkCxPVM6KM7:TR?= Mn:wV2FPT0WU
OE19 NWLVTGRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkO5TWM2OD1yLkCxPVUh|ryP MWrTRW5ITVJ?
RVH-421 NV;YfIRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3q[3VDUUN3ME2wMlAyQTV5IN88US=> M2PwRXNCVkeHUh?=
TE-10 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXNTWM2OD1yLkCxPVc4KM7:TR?= MWPTRW5ITVJ?
A101D NELue5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLmV3lKSzVyPUCuNFE6QDdizszN MXHTRW5ITVJ?
HUTU-80 M4PCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEKwNFQh|ryP M1K0XnNCVkeHUh?=
KYSE-140 M1\JTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEKwNlQh|ryP MUHTRW5ITVJ?
SNU-449 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEKwNlYh|ryP MUjTRW5ITVJ?
697 M{LqSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVn0c3dzUUN3ME2wMlAzODNzIN88US=> M2j5SXNCVkeHUh?=
SJSA-1 NUPVNI44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XLSWlEPTB;MD6wNlA{PyEQvF2= MV7TRW5ITVJ?
IGR-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;1TWM2OD1yLkCyNFUh|ryP MoHjV2FPT0WU
GCIY NEjBUJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEKwOVUh|ryP MkniV2FPT0WU
REH NWrnOFJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmflTWM2OD1yLkCyNFU6KM7:TR?= NYTLRlZiW0GQR1XS
A204 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm2b5RZUUN3ME2wMlAzOTF3IN88US=> NILITG5USU6JRWK=
A388 Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\yTWM2OD1yLkCyNVE2KM7:TR?= NFrkXFFUSU6JRWK=
NCI-H650 M2TOVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rCfmlEPTB;MD6wNlEyPyEQvF2= NH7YdXRUSU6JRWK=
SW626 NU\4bZhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LKbmlEPTB;MD6wNlEzKM7:TR?= NWfmcGJqW0GQR1XS
DoTc2-4510 NELGdY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMEKxNlIh|ryP MoPqV2FPT0WU
HCE-4 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\NRmlEPTB;MD6wNlE1PSEQvF2= MVHTRW5ITVJ?
DU-4475 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLQTWM2OD1yLkCyNVUh|ryP NUf0WGhxW0GQR1XS
A375 NILndphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\mNHloUUN3ME2wMlAzOTdzIN88US=> Mn2zV2FPT0WU
GB-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfI[phKSzVyPUCuNFIyQDhizszN MX\TRW5ITVJ?
CHP-212 NVToTYFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7tTmZKSzVyPUCuNFIzOTJizszN NYr0T5lxW0GQR1XS
HT-1080 MkPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH1ZopKSzVyPUCuNFIzOTRizszN M3\2U3NCVkeHUh?=
M059J M1XGUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEKyOFEh|ryP NVS1SlBwW0GQR1XS
NMC-G1 MlX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfVNWlKSzVyPUCuNFIzQCEQvF2= NYPXVohVW0GQR1XS
MRK-nu-1 NYCwNms4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4L1cWlEPTB;MD6wNlMh|ryP MoSzV2FPT0WU
MFE-296 Mnq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2mze2lEPTB;MD6wNlMzOiEQvF2= NVm3XYpJW0GQR1XS
LOXIMVI MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEKzNlMh|ryP NXTvcGRiW0GQR1XS
CGTH-W-1 NGrHRXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYT3dWxMUUN3ME2wMlAzOzJ6IN88US=> NXzEbXlzW0GQR1XS
CCRF-CEM NHjRZVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\mdHRKSzVyPUCuNFI{OjlizszN MX\TRW5ITVJ?
ACHN M{\TXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PvV2lEPTB;MD6wNlM1PSEQvF2= NUDEcJc2W0GQR1XS
NCI-H1355 MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEK0NFEh|ryP NWTWSHpRW0GQR1XS
NCI-H1651 NXruS3pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\DTWM2OD1yLkCyOFMyKM7:TR?= MkfFV2FPT0WU
KINGS-1 MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTlWpFKSzVyPUCuNFI1OzNizszN NVnVRWw2W0GQR1XS
LS-123 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnYV2pUUUN3ME2wMlAzPDN3IN88US=> M1v1TnNCVkeHUh?=
SNB75 MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrBd3NtUUN3ME2wMlAzPDZ4IN88US=> NXe1Z4s2W0GQR1XS
C3A NFvGc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP3TWM2OD1yLkCyOFc2KM7:TR?= MkeyV2FPT0WU
HO-1-N-1 NIHxO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vYcGlEPTB;MD6wNlU1QSEQvF2= M{jmSXNCVkeHUh?=
EHEB NIXDUHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ywU2lEPTB;MD6wNlU2PSEQvF2= NWXQTIFyW0GQR1XS
CAL-62 M{Pwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPDbndKSzVyPUCuNFI2PyEQvF2= MkizV2FPT0WU
U-118-MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HhOWlEPTB;MD6wNlU4PiEQvF2= NVTvcpFiW0GQR1XS
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KYSE-520 Ml31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP3fHFYUUN3ME2wMlAzPjF|IN88US=> M{THcnNCVkeHUh?=
MZ1-PC NFO4bo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLoTWM2OD1yLkCyOlM6KM7:TR?= NETNRVBUSU6JRWK=
BCPAP MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHlbHNKSzVyPUCuNFI3PDZizszN NEC0cnZUSU6JRWK=
RD MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEK2OVgh|ryP NGrvdFZUSU6JRWK=
NCI-H520 NVywZlZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDtPYdKSzVyPUCuNFI3PjRizszN NEXtfGZUSU6JRWK=
LXF-289 Mn7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfDUJVmUUN3ME2wMlAzPjZ6IN88US=> M2PaNnNCVkeHUh?=
G-361 NEnmc5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEK2O|ch|ryP NYDtW4FnW0GQR1XS
LB996-RCC NE[3TFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXzN5JKSzVyPUCuNFI4OSEQvF2= MoLJV2FPT0WU
COR-L23 NFLVPJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEK3NVMh|ryP NH3SXlRUSU6JRWK=
GP5d MmC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV24WIZ{UUN3ME2wMlAzPzJ|IN88US=> MoPBV2FPT0WU
SW1990 M2LNRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHkU5FKUUN3ME2wMlAzPzJ2IN88US=> MnezV2FPT0WU
PA-1 M2rpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEK3OVUh|ryP MVXTRW5ITVJ?
NCI-H2009 NI\Wb5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H4b2lEPTB;MD6wNlc3KM7:TR?= Mlj6V2FPT0WU
SR MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X3SWlEPTB;MD6wNlc5PSEQvF2= NIfiWnpUSU6JRWK=
Ca9-22 Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\pS2lEPTB;MD6wNlc6PiEQvF2= MlLSV2FPT0WU
SCC-15 NFu0XGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnyyTWM2OD1yLkCyPFAyKM7:TR?= MULTRW5ITVJ?
ETK-1 NWXodoI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXGwSoFtUUN3ME2wMlAzQDB4IN88US=> MkX0V2FPT0WU
SCC-4 NVzYNHFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLaTWM2OD1yLkCyPFA6KM7:TR?= MlT1V2FPT0WU
5637 NVvJXlJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEK4NlIh|ryP MVTTRW5ITVJ?
EW-1 NEXhW5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y3c2lEPTB;MD6wNlgzOiEQvF2= Mn;kV2FPT0WU
SW962 NWjsNWNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NECx[5VKSzVyPUCuNFI5PTJizszN NUPyfHBkW0GQR1XS
HCE-T M2jnSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\hVVFKSzVyPUCuNFI5PiEQvF2= MlizV2FPT0WU
NCI-H2405 M3vjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjrU2RrUUN3ME2wMlAzQDh5IN88US=> MnzDV2FPT0WU
A2058 Ml21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH76XVRKSzVyPUCuNFI6OjlizszN NILDVpVUSU6JRWK=
HCC2998 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr3NphtUUN3ME2wMlAzQTR3IN88US=> NUC2ZWFGW0GQR1XS
ONS-76 M2H3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrWUYs5UUN3ME2wMlAzQTV2IN88US=> MmPmV2FPT0WU
DBTRG-05MG MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPNTWM2OD1yLkCyPVU2KM7:TR?= MYDTRW5ITVJ?
HuCCT1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq4NZFCUUN3ME2wMlAzQTZzIN88US=> NGTERXFUSU6JRWK=
J82 M1zLRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEOwNFch|ryP Mn60V2FPT0WU
MKN28 MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjRTWM2OD1yLkCzNFEzKM7:TR?= Mn3HV2FPT0WU
SW837 NYfXTWZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX6Wo84UUN3ME2wMlA{ODF2IN88US=> M3jXWHNCVkeHUh?=
no-10 NHnaSo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPtfJFsUUN3ME2wMlA{ODF4IN88US=> NEP0dmNUSU6JRWK=
BC-3 NUXkcoh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEOwNVgh|ryP NXLwN4hrW0GQR1XS
no-11 NGDJeG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW1TWM2OD1yLkCzNFQ5KM7:TR?= NU\kUFVWW0GQR1XS
8305C NEW4RpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPye3ROUUN3ME2wMlA{ODd{IN88US=> MoLJV2FPT0WU
COLO-679 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTZ[lBKSzVyPUCuNFMyODdizszN MkPaV2FPT0WU
CESS M2XRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH0dnhKSzVyPUCuNFMyOiEQvF2= MXPTRW5ITVJ?
BFTC-909 NULqVlNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrsdXhkUUN3ME2wMlA{OTJ3IN88US=> NHzTdYhUSU6JRWK=
MZ2-MEL NUXR[nlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEOxO|ch|ryP NWDI[Jk3W0GQR1XS
SW872 NWH4[mp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXWS5Q2UUN3ME2wMlA{OjF5IN88US=> NYjTWolXW0GQR1XS
LB831-BLC M2DkNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf3NZZkUUN3ME2wMlA{OjF7IN88US=> NW\RSHN7W0GQR1XS
SK-UT-1 NX21N4lGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\WV3dKSzVyPUCuNFMzOjFizszN NF33eVRUSU6JRWK=
NCI-H1734 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnVTWM2OD1yLkCzNlMh|ryP MlTsV2FPT0WU
OVCAR-8 NXHmZ4JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonlTWM2OD1yLkCzNlgyKM7:TR?= M4G0RnNCVkeHUh?=
NCI-H2087 Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEOyPFkh|ryP MnqwV2FPT0WU
U-87-MG M2PlVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L1RmlEPTB;MD6wN|I6KM7:TR?= MXXTRW5ITVJ?
BC-1 NH7FXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnZSGpKSzVyPUCuNFM{PjdizszN NWnGfJk1W0GQR1XS
ES7 NXK0XWE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLXUIIzUUN3ME2wMlA{Ozd2IN88US=> Mm\BV2FPT0WU
Daudi NVnjb5RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfQe4ZjUUN3ME2wMlA{Ozd4IN88US=> M4TtXnNCVkeHUh?=
RS4-11 Mmn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHHbWNKSzVyPUCuNFM{QDNizszN NUj4[oo4W0GQR1XS
JiyoyeP-2003 M2jFOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\iRVR1UUN3ME2wMlA{Ozh6IN88US=> NELJeWhUSU6JRWK=
BL-70 NF;NOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTjNohKSzVyPUCuNFM{QDlizszN NGmx[IxUSU6JRWK=
OS-RC-2 NIrlcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEOzPVYh|ryP NG\4dY5USU6JRWK=
SF268 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHJTWM2OD1yLkCzOFAyKM7:TR?= MmfvV2FPT0WU
BV-173 M4rMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXO3NpcyUUN3ME2wMlA{PDJ4IN88US=> MW\TRW5ITVJ?
DMS-273 MkHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDiPW5MUUN3ME2wMlA{PDd7IN88US=> MnraV2FPT0WU
22RV1 Mn\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrkZoFKSzVyPUCuNFM2ODdizszN MVLTRW5ITVJ?
ES8 NVzoUIJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{OySWlEPTB;MD6wN|U{QCEQvF2= MYrTRW5ITVJ?
KYSE-150 NVG3fYhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFqybG9KSzVyPUCuNFM3ODhizszN NG\TTFRUSU6JRWK=
HCC1569 M4ntbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ezWWlEPTB;MD6wN|YxQCEQvF2= NWrOSYpnW0GQR1XS
NB5 M4fuUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDqeWlKSzVyPUCuNFM3OTNizszN NVrMTmlNW0GQR1XS
G-402 M3POcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLjW|N5UUN3ME2wMlA{PjF2IN88US=> MU\TRW5ITVJ?
NCI-H1693 NGfZT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i0UWlEPTB;MD6wN|YyPyEQvF2= MULTRW5ITVJ?
LB2241-RCC MnzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDETWM2OD1yLkCzOlQzKM7:TR?= MnSzV2FPT0WU
KP-4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKxNlN3UUN3ME2wMlA{PjZ|IN88US=> NVfDeGRNW0GQR1XS
ML-2 NGHuOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPJbXlMUUN3ME2wMlA{PjdzIN88US=> NV;oS|RjW0GQR1XS
KU812 NWnqT2NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[2[npKSzVyPUCuNFM3QDRizszN M1flWHNCVkeHUh?=
LS-411N M4P6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDvTWM2OD1yLkCzO|MyKM7:TR?= NV2zRmdrW0GQR1XS
OAW-42 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHe5XFJKSzVyPUCuNFM4PDdizszN MYPTRW5ITVJ?
HCC38 NGqyUmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjVVmZKSzVyPUCuNFM4PzFizszN NFv3UIRUSU6JRWK=
Ca-Ski M3[ybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX0TWM2OD1yLkCzO|g1KM7:TR?= NF[wSodUSU6JRWK=
Calu-3 NWC5N4c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jwR2lEPTB;MD6wN|c5QSEQvF2= NVnldFdwW0GQR1XS
KYSE-70 M1nLSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nxRWlEPTB;MD6wN|gyOiEQvF2= NIKwcFZUSU6JRWK=
D-392MG NVLXWXJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXTc4FYUUN3ME2wMlA{QDR{IN88US=> M{iyO3NCVkeHUh?=
OVCAR-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMEO4OVgh|ryP NIC4R2tUSU6JRWK=
Detroit562 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzwTWM2OD1yLkCzPFczKM7:TR?= Mn30V2FPT0WU
HEL NYjx[|VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjLcZFKSzVyPUCuNFM5QTFizszN M376PXNCVkeHUh?=
MONO-MAC-6 M1jMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEO4PVMh|ryP NUDxUXBOW0GQR1XS
LoVo NHHFS3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzjfZZQUUN3ME2wMlA{QTN|IN88US=> NXezZWZSW0GQR1XS
U-2-OS NI\jXYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PDeGlEPTB;MD6wN|k{PSEQvF2= NYT3ToN2W0GQR1XS
A172 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHHc4JKSzVyPUCuNFM6PSEQvF2= NXXhSWI4W0GQR1XS
OCUB-M NVXRSXV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEO5OlEh|ryP M4fEVXNCVkeHUh?=
SW48 M{HOOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2izbmlEPTB;MD6wOFA{OSEQvF2= NGDXNJlUSU6JRWK=
HC-1 M1\DRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMESwOlkh|ryP Ml;uV2FPT0WU
KOSC-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnjZXREUUN3ME2wMlA1OTFizszN NFq0b41USU6JRWK=
HDLM-2 Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnBeXBKSzVyPUCuNFQyOTRizszN MYPTRW5ITVJ?
CTV-1 NXPYfYNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHLTWM2OD1yLkC0NVE3KM7:TR?= NI[1SHFUSU6JRWK=
SH-4 MoK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMESxOFEh|ryP M3rwV3NCVkeHUh?=
SW756 NUXTT|FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTJNHFKSzVyPUCuNFQyPTdizszN MX7TRW5ITVJ?
GCT NYnlRWVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13VS2lEPTB;MD6wOFE3OSEQvF2= MnfTV2FPT0WU
CHL-1 NXTPc5dET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnwbpZKSzVyPUCuNFQyPjlizszN M{fqcXNCVkeHUh?=
LAMA-84 NUnjUmR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXMVIFKSzVyPUCuNFQyPzFizszN NYLzRXlrW0GQR1XS
LS-1034 NHPSfnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMESxPVEh|ryP Mn[3V2FPT0WU
NCI-H358 NXLw[44yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTFTWM2OD1yLkC0NlEzKM7:TR?= NGTW[WNUSU6JRWK=
NB13 M4\rfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\JTWM2OD1yLkC0NlI4KM7:TR?= Mnz3V2FPT0WU
TE-9 NUjBUotrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMESyN|ch|ryP Mn;EV2FPT0WU
OE33 M1jGUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;2VGlEPTB;MD6wOFI1OSEQvF2= MkL6V2FPT0WU
CAL-120 Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfKTWM2OD1yLkC0NlQyKM7:TR?= NIHvcnVUSU6JRWK=
DJM-1 NWrsc|VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;vdWlEPTB;MD6wOFI4OiEQvF2= MkHRV2FPT0WU
SK-MEL-24 NFrGWGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMESyPFMh|ryP M4i3dHNCVkeHUh?=
VA-ES-BJ NXLPSmVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXqTWM2OD1yLkC0NlkzKM7:TR?= NG\oXHZUSU6JRWK=
MMAC-SF MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMESyPVch|ryP NF7nVYhUSU6JRWK=
MZ7-mel NED5VGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMESzN{DPxE1? MXTTRW5ITVJ?
BxPC-3 MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLud3hUUUN3ME2wMlA1OzRzIN88US=> NY\ic2VJW0GQR1XS
HT-29 M3LGNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMESzOVch|ryP MUjTRW5ITVJ?
SK-MEL-30 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMESzOlIh|ryP M2\XNHNCVkeHUh?=
CAL-33 NGrVd5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkO4TWM2OD1yLkC0N|c2KM7:TR?= MXfTRW5ITVJ?
COLO-680N MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmzSHVWUUN3ME2wMlA1PDB5IN88US=> MmroV2FPT0WU
NH-12 Mn3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TyXWlEPTB;MD6wOFQ1KM7:TR?= NGfOfWhUSU6JRWK=
HCC1937 NGHpfWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTTTWM2OD1yLkC0OFU3KM7:TR?= MYLTRW5ITVJ?
IMR-5 MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXrdYZXUUN3ME2wMlA1PDlizszN M1X2NHNCVkeHUh?=
MC-CAR NIDyNXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3HdphKSzVyPUCuNFQ2PjlizszN M3LEcXNCVkeHUh?=
NCI-H747 NF;rN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\UTWM2OD1yLkC0OVch|ryP MnnCV2FPT0WU
NCI-H1792 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrWXpZWUUN3ME2wMlA1PThzIN88US=> MXrTRW5ITVJ?
SW13 M4npRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3zTWM2OD1yLkC0OVkh|ryP MmDBV2FPT0WU
MLMA M2PweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMES2NFkh|ryP MUTTRW5ITVJ?
U251 NV36Zow4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjpTWM2OD1yLkC0O|Y{KM7:TR?= NIfvZ2hUSU6JRWK=
U031 NVGzUmNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHJbZNKSzVyPUCuNFQ4PzFizszN M1zLZ3NCVkeHUh?=
ME-180 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LlTmlEPTB;MD6wOFc5OiEQvF2= NX3ncFY3W0GQR1XS
SK-MEL-3 NGjFRYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13VZmlEPTB;MD6wOFgxOiEQvF2= NW[5doM{W0GQR1XS
MOLT-4 NGXsflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XzXWlEPTB;MD6wOFgxOyEQvF2= M1zqWXNCVkeHUh?=
PF-382 MnPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzoU2ZKSzVyPUCuNFQ5OjZizszN Mlr2V2FPT0WU
NUGC-3 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj2TWM2OD1yLkC0PFI4KM7:TR?= NFjZSWtUSU6JRWK=
NCI-H1417 M3j2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlGyTWM2OD1yLkC0PFkh|ryP NH;4WpFUSU6JRWK=
COLO-205 Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK0cZc5UUN3ME2wMlA1QTF7IN88US=> NYf4d2hJW0GQR1XS
TE-441-T MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMES5N{DPxE1? M2rDRnNCVkeHUh?=
MKN1 NHT5cpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jycWlEPTB;MD6wOFk{KM7:TR?= NFnYZmdUSU6JRWK=
UM-UC-3 NYPQVmN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrJRWJ[UUN3ME2wMlA1QTVizszN NE\zTYVUSU6JRWK=
SF126 M1T2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzKeYhKSzVyPUCuNFUxOSEQvF2= MU\TRW5ITVJ?
LB1047-RCC NGnIUo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjueZFKSzVyPUCuNFUxOzFizszN M3T5eHNCVkeHUh?=
A253 NUfUfVRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHqRodvUUN3ME2wMlA2ODV{IN88US=> MYrTRW5ITVJ?
NCI-H1963 M3jZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnLTWM2OD1yLkC1NVc3KM7:TR?= M{XnVHNCVkeHUh?=
VM-CUB-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3mxTWlEPTB;MD6wOVMyOSEQvF2= NVu0eGl2W0GQR1XS
T-24 M4\wNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT3TWM2OD1yLkC1N|g1KM7:TR?= M1fGVHNCVkeHUh?=
K-562 M12x[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX5TWM2OD1yLkC1N|g4KM7:TR?= NHz6W2FUSU6JRWK=
ARH-77 NUjpPGdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofJTWM2OD1yLkC1N|k2KM7:TR?= MWHTRW5ITVJ?
CA46 Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjwToJKSzVyPUCuNFU1OyEQvF2= MUDTRW5ITVJ?
HCC70 MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX61em5GUUN3ME2wMlA2PDV{IN88US=> NIewdGtUSU6JRWK=
ST486 NVjkU|BNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEC0XY1KSzVyPUCuNFU2OjVizszN M3jSVXNCVkeHUh?=
COLO-741 MmLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzZUnFkUUN3ME2wMlA2PTNzIN88US=> M4\me3NCVkeHUh?=
SK-PN-DW M13sfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEW1PFgh|ryP M4jKW3NCVkeHUh?=
BL-41 MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7pSZRKSzVyPUCuNFU2QTZizszN MYTTRW5ITVJ?
D-263MG NYPoTJlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfxT3VKSzVyPUCuNFU3QDNizszN MW\TRW5ITVJ?
KE-37 NXfIUHZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X2UWlEPTB;MD6wOVY5OyEQvF2= NH;ESWJUSU6JRWK=
LU-134-A MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXSfmc4UUN3ME2wMlA2PzF3IN88US=> M1XUenNCVkeHUh?=
HCC2157 NIiwSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2njOmlEPTB;MD6wOVc{OyEQvF2= MmXtV2FPT0WU
GAK NV35T41tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLtZlVlUUN3ME2wMlA2PzN2IN88US=> NYrPd5I6W0GQR1XS
IST-SL2 MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjJTY9KSzVyPUCuNFU4PDNizszN MlrEV2FPT0WU
KMOE-2 M3jjO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETwVYdKSzVyPUCuNFU4PDlizszN MXTTRW5ITVJ?
SW1573 NVv4eIJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmm2TWM2OD1yLkC1PFAzKM7:TR?= NHXJO|ZUSU6JRWK=
SCC-9 NYn3enlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\ud4FTUUN3ME2wMlA2QDdizszN M2fHbnNCVkeHUh?=
MDA-MB-361 NVr0dmN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknQTWM2OD1yLkC1PFczKM7:TR?= M33qWHNCVkeHUh?=
BHT-101 M2f1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33SUGlEPTB;MD6wOVg4PiEQvF2= MorpV2FPT0WU
NCI-H1770 Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1eyfGlEPTB;MD6wOVg4QSEQvF2= NHW3SWhUSU6JRWK=
UACC-893 M4LvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF6wb4hKSzVyPUCuNFU5QTZizszN NEnvT2pUSU6JRWK=
NCI-H226 NUjCeWgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\VSJFQUUN3ME2wMlA2QTh6IN88US=> NGXOO2RUSU6JRWK=
HLE MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\XUWx1UUN3ME2wMlA3ODh{IN88US=> MYTTRW5ITVJ?
NCI-H1703 NEnBV2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDzcFlKSzVyPUCuNFYyPzhizszN NXLjWHdGW0GQR1XS
KURAMOCHI MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT5TWM2OD1yLkC2NVg6KM7:TR?= MWXTRW5ITVJ?
RH-1 M2TxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDSOmRKSzVyPUCuNFYzOyEQvF2= NF7EO|NUSU6JRWK=
DSH1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDhTWM2OD1yLkC2Nlch|ryP MWLTRW5ITVJ?
CAMA-1 MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLqTWM2OD1yLkC2N|A{KM7:TR?= NFL5b3FUSU6JRWK=
NCI-H1437 NV7xepdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwME[zNlgh|ryP NWS5dVhzW0GQR1XS
HuP-T4 M1nTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnDOXRKSzVyPUCuNFY2QDZizszN M13kZ3NCVkeHUh?=
HCT-15 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{e1VWlEPTB;MD6wOlU6PyEQvF2= MnjiV2FPT0WU
NCCIT Mmf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwME[2NFQh|ryP NYfHOIR1W0GQR1XS
BOKU NXrlXHFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPXOYxbUUN3ME2wMlA3Pjd2IN88US=> NEfyNI9USU6JRWK=
FADU NXPYW3lGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwME[3OFUh|ryP NWP0[|JtW0GQR1XS
SUP-T1 M4fENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn3UlNwUUN3ME2wMlA3PzZizszN MVfTRW5ITVJ?
L-363 M{S0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwME[5NFEh|ryP MnL0V2FPT0WU
KNS-81-FD NF:1RoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;nXHZKSzVyPUCuNFY6OThizszN NUDRc2JbW0GQR1XS
SU-DHL-1 NGrFNpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwME[5NkDPxE1? NXjy[Y5[W0GQR1XS
HuH-7 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTub5FKSzVyPUCuNFcxOzVizszN MUHTRW5ITVJ?
BT-474 NWmze5V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\NTWM2OD1yLkC3NFYyKM7:TR?= MmLEV2FPT0WU
CAPAN-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\kWZROUUN3ME2wMlA4OTR|IN88US=> NX;0UHZMW0GQR1XS
HEC-1 MmK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4W5eGlEPTB;MD6wO|E3OSEQvF2= M3m5enNCVkeHUh?=
NOMO-1 MljWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjGcZJKSzVyPUCuNFcyPzJizszN NHHMdXFUSU6JRWK=
KM-H2 MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEeyOFEh|ryP NYrJfpo{W0GQR1XS
EB2 MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TCT2lEPTB;MD6wO|I5PSEQvF2= MVTTRW5ITVJ?
LU-99A MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEeyPFch|ryP MYXTRW5ITVJ?
WSU-NHL M1zSO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEezNlkh|ryP MWrTRW5ITVJ?
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SK-MEL-28 NXjlSIx4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PMNGlEPTB;Mj6xPFA6QCEQvF2= NFnWXo9USU6JRWK=
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NCI-H720 M3zJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojFTWM2OD1{LkK2OVg2KM7:TR?= NFHBdHpUSU6JRWK=
CAL-54 MnLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTJWG5KSzVyPUKuNlY4QTVizszN NV\MOHZRW0GQR1XS
MC116 NGXvNWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PMe2lEPTB;Mj6zOlM6PyEQvF2= MYPTRW5ITVJ?
DG-75 NVWyS4lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3KTWM2OD1{LkS4OVc3KM7:TR?= NGThfoFUSU6JRWK=
HCC1143 NVvXXFZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\0eWlEPTB;Mj61NFY2QCEQvF2= NWDEOZpDW0GQR1XS
FTC-133 M2nqfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJwNUO2PFkh|ryP MYHTRW5ITVJ?
AsPC-1 MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJwNUO5Nlkh|ryP M1rhOXNCVkeHUh?=
NCI-H889 NIf4PW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJwNU[3NFYh|ryP NHLOTm9USU6JRWK=
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UMC-11 NYH3e|ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfwdZRxUUN3ME2yMlc5PzF3IN88US=> NV7YOHJPW0GQR1XS
P12-ICHIKAWA MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\SWJRKSzVyPUKuPFIxPDZizszN M{K0dHNCVkeHUh?=
HCC1395 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH4UGluUUN3ME2yMlk5PjB{IN88US=> M1PWV3NCVkeHUh?=
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COLO-800 NHX3XJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH5bXpTUUN3ME2zMlM{QDl5IN88US=> NX;xSnlwW0GQR1XS
MFM-223 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTWe21jUUN3ME2zMlM3ODl5IN88US=> NWr2OFhKW0GQR1XS
TE-5 MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfuZWp4UUN3ME20MlU3OTR5IN88US=> MUjTRW5ITVJ?
NCI-H209 NWHrVFZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2exSWlEPTB;ND63PFU4OiEQvF2= M333OXNCVkeHUh?=
SiHa MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTYO3pKSzVyPUSuPVUzODNizszN M4TPbnNCVkeHUh?=
NCI-H1395 MlrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjPTWM2OD13LkGwOlM{KM7:TR?= MkS4V2FPT0WU
A498 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LZdWlEPTB;NT6yNVI2OSEQvF2= NH21RXJUSU6JRWK=
ES5 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XEcWlEPTB;NT62NVE4QCEQvF2= MWHTRW5ITVJ?
MDA-MB-157 NGK4RYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TJ[mlEPTB;NT62OlQ1OyEQvF2= NH2yNXhUSU6JRWK=
NCI-H1623 NV71T3BbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\BSGlEPTB;NT64N|U2PiEQvF2= MVnTRW5ITVJ?
RPMI-8866 NXzm[lZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLxT3ZKSzVyPUWuPFQ4QTJizszN NWnUTWx[W0GQR1XS
LC-1F NF64clBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonXTWM2OD14LkC5NlkyKM7:TR?= NHO3bZFUSU6JRWK=
TCCSUP Ml;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYOwTXBwUUN3ME22MlYxOzR7IN88US=> MlLpV2FPT0WU
TT MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[wTI5qUUN3ME24MlM{ODB7IN88US=> MmH4V2FPT0WU
NCI-H1838 MmG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRThwNUG3N|Eh|ryP MWDTRW5ITVJ?
NCI-H322M MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPDcHhKSzVyPUmuNVYzQDFizszN NF;OVGhUSU6JRWK=
NCI-H187 Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvaTWM2OD17LkWxPFM2KM7:TR?= MYTTRW5ITVJ?
SBC-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITocIxKSzVyPUmuPVM3PTZizszN MoPDV2FPT0WU
SCC-3 NV\Le5I{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrWN2JCUUN3ME2xNE42Pjd7IN88US=> MmDYV2FPT0WU
SW948 M3HxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTFyLke1NVEh|ryP MlLrV2FPT0WU
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TGBC24TKB MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGxTWM2OD1zMz61Nlkh|ryP NULGbmlIW0GQR1XS
NCI-H2452 MmXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDRTWM2OD1zND63N{DPxE1? M3TB[HNCVkeHUh?=
Hs-578-T MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnv4TWM2OD1zOD61O|U6KM7:TR?= MXTTRW5ITVJ?
DV-90 M1:2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPZPJRvUUN3ME2xPE46QTR3IN88US=> Mn3tV2FPT0WU
NCI-H1563 NX\OTIplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\NU3ZKSzVyPUG5Mlc5QDhizszN MUXTRW5ITVJ?
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NCI-H345 NIDNTJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO4XY55UUN3ME2yNU45Pzd7IN88US=> Mn3wV2FPT0WU
LB771-HNC M1LmNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2KwbGlEPTB;MkKuOFgyOyEQvF2= MYfTRW5ITVJ?
RT4 M{fmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m3N2lEPTB;MkOuN|I5OiEQvF2= MXzTRW5ITVJ?
NCI-H82 NVv0cnh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zYcmlEPTB;MkOuOVUzPiEQvF2= MmDuV2FPT0WU
NCI-H524 NHzUc|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LHWWlEPTB;MkSuN|gyOiEQvF2= NFiwO5dUSU6JRWK=
SNU-C1 NVLLZ5o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jPR2lEPTB;MkSuPVExPSEQvF2= NWi5VWVJW0GQR1XS
NCI-SNU-16 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1OxNWlEPTB;NEiuN|E1OiEQvF2= NYjLZndpW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

細胞アッセイ: [1]

細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

動物実験: [3]

動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
製剤 In DMSO and diluted in sterile saline/Tween 20
投薬量 50 mg/kg
投与方法 Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Luminespib (AUY-922, NVP-AUY922) SDF
分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管 3年-20℃
2年-80℃in solvent
別名 VER-52296
溶解度 (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

文献中の引用 (23)

技術サポート&よくある質問(FAQ)

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* 必須

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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