Luminespib (AUY-922, NVP-AUY922) 化学構造
分子量: 465.54

高品質保証

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Quality Control & MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野
  • Luminespib (AUY-922, NVP-AUY922)のメカニズム

製品の説明

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。
ターゲット HSP90α HSP90β
IC50 13 nM 21 nM [1]
In vitro試験 NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMK NFjtbm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;HOI06UUN3ME2wMlAxODF{NTFOwG0> NFzYS4VUSU6JRWK=
MV-4-11 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMECwOVU5KM7:TR?= NF3oUZZUSU6JRWK=
NALM-6 NFzvV|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMECwPFQzKM7:TR?= NXv1U5dlW0GQR1XS
HOS MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHhcoIxUUN3ME2wMlAxOTN6IN88US=> NGT6XYdUSU6JRWK=
HT-144 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;rOJFKSzVyPUCuNFAyPTVizszN MUDTRW5ITVJ?
SW1710 Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrjPXZKSzVyPUCuNFAyQDZizszN NYTDbYVnW0GQR1XS
TE-8 NX2yeZBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoToTWM2OD1yLkCwNlM4KM7:TR?= MVLTRW5ITVJ?
ES1 NF;tPJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnWUVRKSzVyPUCuNFAzPjZizszN NFW4RnFUSU6JRWK=
CCF-STTG1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMECyPVch|ryP MUnTRW5ITVJ?
PSN1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXPSo1{UUN3ME2wMlAxOzF6IN88US=> NIDjb4tUSU6JRWK=
CAL-51 M4PEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HzPWlEPTB;MD6wNFMzPSEQvF2= MU\TRW5ITVJ?
MCF7 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMECzN|Uh|ryP NFXhcpdUSU6JRWK=
SK-HEP-1 NFL6cmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rkTGlEPTB;MD6wNFM{PiEQvF2= NFG4dYVUSU6JRWK=
LCLC-103H NIXx[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn6V4Z7UUN3ME2wMlAxPDNizszN Ml;GV2FPT0WU
HMV-II NYro[pl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL2TWM2OD1yLkCwOFQ6KM7:TR?= NVfZWXVDW0GQR1XS
MES-SA MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn1cGo6UUN3ME2wMlAxPDV{IN88US=> MWnTRW5ITVJ?
SK-LMS-1 MnHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMEC0OVgh|ryP NGW5[GJUSU6JRWK=
639-V NF:2b3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEC0PFUh|ryP M1;xRXNCVkeHUh?=
SIG-M5 NIf6UmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEC0PFkh|ryP MluwV2FPT0WU
LOUCY NHzsc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXEV3ZJUUN3ME2wMlAxPTB3IN88US=> NIm5OnZUSU6JRWK=
HSC-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHkUI5lUUN3ME2wMlAxPTF6IN88US=> MYPTRW5ITVJ?
EW-13 MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;hZmlEPTB;MD6wNFUyQCEQvF2= NUXLOJFuW0GQR1XS
RT-112 M{HheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M323[2lEPTB;MD6wNFU{PSEQvF2= M{PKbnNCVkeHUh?=
NKM-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEC1OFch|ryP M4nTVnNCVkeHUh?=
KYSE-180 NWrMSJJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXPVY5KSzVyPUCuNFA2QDZizszN NWW2[ItXW0GQR1XS
SW1783 MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEC1PVEh|ryP MoryV2FPT0WU
A431 MoS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XXRWlEPTB;MD6wNFYxPyEQvF2= NG\Z[WZUSU6JRWK=
SK-OV-3 NGfyeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHGTWM2OD1yLkCwOlMh|ryP NYP5Z|RRW0GQR1XS
RPMI-7951 M2rUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX1[HJuUUN3ME2wMlAxPjNzIN88US=> MVfTRW5ITVJ?
Capan-2 NWjY[HF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEC2N|gh|ryP M2jRTHNCVkeHUh?=
HSC-3 M3PiRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nse2lEPTB;MD6wNFY1OSEQvF2= MUnTRW5ITVJ?
786-0 Mkf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELtOXhKSzVyPUCuNFA3PjNizszN MmXWV2FPT0WU
Daoy M3;XTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jhe2lEPTB;MD6wNFY6PSEQvF2= MoLYV2FPT0WU
KGN NUjSSVdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXoTWM2OD1yLkCwO|A{KM7:TR?= M3f6TXNCVkeHUh?=
EW-16 M1jWNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEC3OFkh|ryP Mn;QV2FPT0WU
EW-7 NF7zVlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy1NoJOUUN3ME2wMlAxPzV2IN88US=> NYHNZmlKW0GQR1XS
IGROV-1 M3zsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjM[YZPUUN3ME2wMlAxQDF2IN88US=> NV3WZZcxW0GQR1XS
8505C MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPDVIpKSzVyPUCuNFA5OjFizszN Mn:4V2FPT0WU
RKO M{jBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2n0PGlEPTB;MD6wNFgzPiEQvF2= NYPQWpFyW0GQR1XS
GDM-1 M1zIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XiTmlEPTB;MD6wNFg1KM7:TR?= NWXZeHhNW0GQR1XS
IST-MEL1 M2TNW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV36T5hVUUN3ME2wMlAxQDV{IN88US=> MnnmV2FPT0WU
RPMI-6666 M3j1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\iO2lEPTB;MD6wNFg2OiEQvF2= MYnTRW5ITVJ?
SNG-M MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUntdmlGUUN3ME2wMlAxQDV4IN88US=> NX;5eZBrW0GQR1XS
KS-1 NHfPfFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK3S|dkUUN3ME2wMlAxQDV7IN88US=> MWjTRW5ITVJ?
RXF393 M{jhemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnYS3I2UUN3ME2wMlAxQDZizszN NUK1[3F4W0GQR1XS
CAL-12T Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEC5NlIh|ryP M{TBPXNCVkeHUh?=
BFTC-905 M1HCdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTLTWM2OD1yLkCwPVM5KM7:TR?= MYHTRW5ITVJ?
SK-MES-1 Mmj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\xOGlEPTB;MD6wNFk1PSEQvF2= M3[3U3NCVkeHUh?=
BB30-HNC M4DMWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T2[2lEPTB;MD6wNFk2OiEQvF2= M4rKW3NCVkeHUh?=
AN3-CA NE\yO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor2TWM2OD1yLkCxNFE4KM7:TR?= NHT6W|NUSU6JRWK=
EFO-27 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX0TWM2OD1yLkCxNFE4KM7:TR?= NWiyPIpXW0GQR1XS
G-401 M4e3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEGwNlUh|ryP MkSxV2FPT0WU
BPH-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\TTWM2OD1yLkCxNFMh|ryP MnvoV2FPT0WU
NCI-H727 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDhfmRKSzVyPUCuNFExOyEQvF2= M3XJSXNCVkeHUh?=
SNU-423 NIfWUYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\obnRvUUN3ME2wMlAyODV|IN88US=> MVfTRW5ITVJ?
KYSE-270 M33RSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoCyTWM2OD1yLkCxNFU6KM7:TR?= NVTIRmNIW0GQR1XS
AGS MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HPe2lEPTB;MD6wNVA3OSEQvF2= MX7TRW5ITVJ?
NCI-H2228 NIixW|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILEfJVKSzVyPUCuNFExPjRizszN MUXTRW5ITVJ?
SW954 NETkTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEGwO|Eh|ryP M{j0SHNCVkeHUh?=
769-P MoTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEGwO|Mh|ryP M3LXPXNCVkeHUh?=
BB49-HNC NFPjdY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTpR4ZKSzVyPUCuNFExPzdizszN NWHCNYI{W0GQR1XS
IA-LM MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEGwPFYh|ryP NUO0RolKW0GQR1XS
NB69 M1r6O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLtUpFKSzVyPUCuNFEyODJizszN NF3TVYlUSU6JRWK=
C8166 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHVOIxPUUN3ME2wMlAyOTJ7IN88US=> NXPF[4pDW0GQR1XS
NCI-H1299 M33ue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTFTWM2OD1yLkCxNVU1KM7:TR?= Mle2V2FPT0WU
YKG-1 MnfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7qbI13UUN3ME2wMlAyOTZizszN MVLTRW5ITVJ?
PANC-03-27 NH33ZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEGxOlIh|ryP MVTTRW5ITVJ?
YT M2rSO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTITWM2OD1yLkCxNVc6KM7:TR?= MV;TRW5ITVJ?
CAL-85-1 M4PQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i1b2lEPTB;MD6wNVE6OiEQvF2= M2[5fHNCVkeHUh?=
GT3TKB NIn5VHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS1fW1EUUN3ME2wMlAyOjB{IN88US=> NVHXW3FiW0GQR1XS
BB65-RCC MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\mTWM2OD1yLkCxNlA1KM7:TR?= M{jNUHNCVkeHUh?=
ES6 MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HoW2lEPTB;MD6wNVI3OSEQvF2= NGq1folUSU6JRWK=
MHH-ES-1 NF3vbWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfK[3oyUUN3ME2wMlAyOjZ|IN88US=> MWDTRW5ITVJ?
QIMR-WIL NVPYcJRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:1TWM2OD1yLkCxNlY6KM7:TR?= MUXTRW5ITVJ?
SNU-C2B NGqyfI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHodolKSzVyPUCuNFEzPzJizszN MkDIV2FPT0WU
OCI-AML2 M2LWfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4SwTGlEPTB;MD6wNVI5OSEQvF2= MUnTRW5ITVJ?
DU-145 MljaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXNUVdKSzVyPUCuNFEzQSEQvF2= MYfTRW5ITVJ?
SW982 NUPDRZRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPZOFlKSzVyPUCuNFEzQTNizszN NX7xcWNbW0GQR1XS
MFH-ino MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PVW2lEPTB;MD6wNVI6OyEQvF2= NUfLZ4loW0GQR1XS
A427 NW\lTFg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn3fGtVUUN3ME2wMlAyOjl7IN88US=> MXLTRW5ITVJ?
LCLC-97TM1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVmxTnNCUUN3ME2wMlAyOyEQvF2= MmDPV2FPT0WU
AM-38 M37m[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEGzNFIh|ryP MlvxV2FPT0WU
K5 NWTQ[JlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHnW2dGUUN3ME2wMlAyOzB6IN88US=> MVTTRW5ITVJ?
T84 NU\idoFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{K4d2lEPTB;MD6wNVM{OSEQvF2= NEftUlNUSU6JRWK=
TE-15 NIr0b|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEGzN|Yh|ryP NWiw[ZZwW0GQR1XS
NCI-H460 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUSybVBKUUN3ME2wMlAyOzN4IN88US=> NFfi[IpUSU6JRWK=
NTERA-S-cl-D1 NHn6XGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LrWmlEPTB;MD6wNVM{QSEQvF2= M3TucHNCVkeHUh?=
KYSE-450 MkL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DUOWlEPTB;MD6wNVM1QSEQvF2= NXzmWYVRW0GQR1XS
H4 NUXjV4JpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:0PGlEPTB;MD6wNVM3PiEQvF2= NUTVbllLW0GQR1XS
LC-2-ad Ml;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH24SVdKSzVyPUCuNFE{PyEQvF2= MofOV2FPT0WU
GAMG MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEGzO|Eh|ryP Ml;xV2FPT0WU
TK10 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S4VGlEPTB;MD6wNVM5OiEQvF2= MonwV2FPT0WU
NCI-H2122 NHv3d5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\ob4pIUUN3ME2wMlAyOzh2IN88US=> NYC4TWlnW0GQR1XS
KM12 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEGzPVkh|ryP MX\TRW5ITVJ?
CAL-39 NEm4ZY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEG0NkDPxE1? MlPCV2FPT0WU
RPMI-2650 Ml21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP0NFVKSzVyPUCuNFE1OzJizszN NVm1OphJW0GQR1XS
KYSE-510 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLETWM2OD1yLkCxOFQzKM7:TR?= Ml23V2FPT0WU
KALS-1 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG0TWM2OD1yLkCxOFY3KM7:TR?= NGTZU5dUSU6JRWK=
NCI-H1648 NGT4TmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zVWWlEPTB;MD6wNVQ6QSEQvF2= NIDOV5lUSU6JRWK=
ES4 NIn0dFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEG1NFIh|ryP MnnzV2FPT0WU
C-33-A MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDES2FqUUN3ME2wMlAyPTB7IN88US=> NHvGZotUSU6JRWK=
MIA-PaCa-2 NHX5cIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEG1NFkh|ryP MYXTRW5ITVJ?
Becker MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XjNGlEPTB;MD6wNVUyPCEQvF2= NHvJUnZUSU6JRWK=
HOP-62 M3u2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEG1OFIh|ryP NHXacHdUSU6JRWK=
TE-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTBOHJKSzVyPUCuNFE2QDFizszN MoTRV2FPT0WU
KYSE-410 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEG1PFYh|ryP NFXz[XVUSU6JRWK=
NOS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M32x[GlEPTB;MD6wNVU6OyEQvF2= Mn;sV2FPT0WU
MEL-HO NVPofVNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\kcWlEPTB;MD6wNVY1OyEQvF2= MW\TRW5ITVJ?
NCI-H1650 MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fyU2lEPTB;MD6wNVY1PiEQvF2= NH\oblFUSU6JRWK=
VMRC-RCZ MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEG2OVEh|ryP NEDke2JUSU6JRWK=
HuP-T3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX0OJpDUUN3ME2wMlAyPjV|IN88US=> MVrTRW5ITVJ?
ACN Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLqTWM2OD1yLkCxOlU4KM7:TR?= MnLRV2FPT0WU
MEL-JUSO NV3tcW9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fifGlEPTB;MD6wNVY5OSEQvF2= NXXMNG9SW0GQR1XS
HT-1197 NWjwfVdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPLdGlkUUN3ME2wMlAyPjh3IN88US=> Mn3EV2FPT0WU
NCI-H2030 NXm2Ro5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi4OHJKSzVyPUCuNFE3QTdizszN NULpPIlqW0GQR1XS
A4-Fuk NFzJVJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fCbWlEPTB;MD6wNVcxOiEQvF2= MlrmV2FPT0WU
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COR-L23 MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXBUIVVUUN3ME2wMlAzPzF|IN88US=> MVjTRW5ITVJ?
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BC-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEOwNVgh|ryP MonXV2FPT0WU
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BC-1 NHnhbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEOzOlch|ryP NF\Yb2FUSU6JRWK=
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BV-173 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHCXYNoUUN3ME2wMlA{PDJ4IN88US=> Mly0V2FPT0WU
DMS-273 Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLuXnFuUUN3ME2wMlA{PDd7IN88US=> NGPTRYtUSU6JRWK=
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ES8 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEO1N|gh|ryP MULTRW5ITVJ?
KYSE-150 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;RV2lEPTB;MD6wN|YxQCEQvF2= Mlj3V2FPT0WU
HCC1569 NYryUYhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH5cXRKSzVyPUCuNFM3ODhizszN NVrCZVc{W0GQR1XS
NB5 NFXOSVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUKxOIVWUUN3ME2wMlA{PjF|IN88US=> NFKxW25USU6JRWK=
G-402 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXmwOoZNUUN3ME2wMlA{PjF2IN88US=> MUXTRW5ITVJ?
NCI-H1693 MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEO2NVch|ryP NVv3c21XW0GQR1XS
LB2241-RCC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDRToxKSzVyPUCuNFM3PDJizszN NHzK[5NUSU6JRWK=
KP-4 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrwbIVKSzVyPUCuNFM3PjNizszN NGC4WppUSU6JRWK=
ML-2 M3vMXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\hTWM2OD1yLkCzOlcyKM7:TR?= M2\3ZnNCVkeHUh?=
KU812 NVPlPJRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LSWGlEPTB;MD6wN|Y5PCEQvF2= NGjhSYlUSU6JRWK=
LS-411N M37wO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPWVolLUUN3ME2wMlA{PzNzIN88US=> NXO1Z5NCW0GQR1XS
OAW-42 NEL5WoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEO3OFch|ryP MWPTRW5ITVJ?
HCC38 MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjNR5lKSzVyPUCuNFM4PzFizszN Mn\yV2FPT0WU
Ca-Ski MmT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LzUmlEPTB;MD6wN|c5PCEQvF2= MV7TRW5ITVJ?
Calu-3 M2\JZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\oNXJGUUN3ME2wMlA{Pzh7IN88US=> Ml;hV2FPT0WU
KYSE-70 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTjN3c5UUN3ME2wMlA{QDF{IN88US=> MljYV2FPT0WU
D-392MG NYjjRoZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DMOGlEPTB;MD6wN|g1OiEQvF2= M2PCTXNCVkeHUh?=
OVCAR-4 NGDOWmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLXTWM2OD1yLkCzPFU5KM7:TR?= NFflO2xUSU6JRWK=
Detroit562 M{DYO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEO4O|Ih|ryP MXnTRW5ITVJ?
HEL MmHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq5TWM2OD1yLkCzPFkyKM7:TR?= MV3TRW5ITVJ?
MONO-MAC-6 NEjxToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInUXVNKSzVyPUCuNFM5QTNizszN NGDQN5NUSU6JRWK=
LoVo MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEO5N|Mh|ryP M2\hTHNCVkeHUh?=
U-2-OS M1vJXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTkTWM2OD1yLkCzPVM2KM7:TR?= MlfIV2FPT0WU
A172 M2PlU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEO5OUDPxE1? Mm\uV2FPT0WU
OCUB-M MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXO2dYdbUUN3ME2wMlA{QTZzIN88US=> M{n4UXNCVkeHUh?=
SW48 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLuTWM2OD1yLkC0NFMyKM7:TR?= M1zRVXNCVkeHUh?=
HC-1 NGHOO49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[xTWM2OD1yLkC0NFY6KM7:TR?= M1rrfHNCVkeHUh?=
KOSC-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMESxNUDPxE1? MlnDV2FPT0WU
HDLM-2 M{\lcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXYTWM2OD1yLkC0NVE1KM7:TR?= MmPlV2FPT0WU
CTV-1 NWL1N3kzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{CzO2lEPTB;MD6wOFEyPiEQvF2= Mn3SV2FPT0WU
SH-4 Mo\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUftUmJTUUN3ME2wMlA1OTRzIN88US=> M3fxR3NCVkeHUh?=
SW756 NGTsbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMESxOVch|ryP M3TBW3NCVkeHUh?=
GCT MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWO4VohNUUN3ME2wMlA1OTZzIN88US=> MUjTRW5ITVJ?
CHL-1 Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMESxOlkh|ryP MoHlV2FPT0WU
LAMA-84 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnsUYRKSzVyPUCuNFQyPzFizszN MX\TRW5ITVJ?
LS-1034 NYHjcGdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rR[WlEPTB;MD6wOFE6OSEQvF2= MlLuV2FPT0WU
NCI-H358 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMESyNVIh|ryP NYTRV|V3W0GQR1XS
NB13 NWPpfFd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\KVZRKSzVyPUCuNFQzOjdizszN M16zUnNCVkeHUh?=
TE-9 MorSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn5TWM2OD1yLkC0NlM4KM7:TR?= NGDIUIFUSU6JRWK=
OE33 NFf2bVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DYe2lEPTB;MD6wOFI1OSEQvF2= MV7TRW5ITVJ?
CAL-120 MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMESyOFEh|ryP MnTJV2FPT0WU
DJM-1 NFTSdGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMESyO|Ih|ryP NH22[HBUSU6JRWK=
SK-MEL-24 NVnaR5VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFy3PG9KSzVyPUCuNFQzQDNizszN M16zOXNCVkeHUh?=
VA-ES-BJ M4\rTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELK[W1KSzVyPUCuNFQzQTJizszN MX;TRW5ITVJ?
MMAC-SF MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMESyPVch|ryP M4HTNHNCVkeHUh?=
MZ7-mel MlnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTXTWM2OD1yLkC0N|Mh|ryP M3vJ[XNCVkeHUh?=
BxPC-3 NUHabXdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jwO2lEPTB;MD6wOFM1OSEQvF2= NHrNWJFUSU6JRWK=
HT-29 NVXLeVZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PT[2lEPTB;MD6wOFM2PyEQvF2= NX73UVNZW0GQR1XS
SK-MEL-30 NXX0cZpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrJPIF[UUN3ME2wMlA1OzZ{IN88US=> MlXMV2FPT0WU
CAL-33 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG2TWM2OD1yLkC0N|c2KM7:TR?= MnLNV2FPT0WU
COLO-680N MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMES0NFch|ryP NXK3Nmh2W0GQR1XS
NH-12 M1fNXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nNVGlEPTB;MD6wOFQ1KM7:TR?= MoXHV2FPT0WU
HCC1937 Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnIW5NEUUN3ME2wMlA1PDV4IN88US=> M4TsUHNCVkeHUh?=
IMR-5 NFG5cZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPRTWM2OD1yLkC0OFkh|ryP Mk\XV2FPT0WU
MC-CAR MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInaN5FKSzVyPUCuNFQ2PjlizszN MkTGV2FPT0WU
NCI-H747 NX73PIVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMES1O{DPxE1? NH;5d2ZUSU6JRWK=
NCI-H1792 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;FTWM2OD1yLkC0OVgyKM7:TR?= MULTRW5ITVJ?
SW13 NHfXVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\0OmhKSzVyPUCuNFQ2QSEQvF2= NHztNGNUSU6JRWK=
MLMA NVj6eI9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzwXGRKSzVyPUCuNFQ3ODlizszN MmDFV2FPT0WU
U251 Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHyyeYdKSzVyPUCuNFQ4PjNizszN MmniV2FPT0WU
U031 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf5TWM2OD1yLkC0O|cyKM7:TR?= M1W0OXNCVkeHUh?=
ME-180 NUfsTG5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PSWWlEPTB;MD6wOFc5OiEQvF2= M4LyUnNCVkeHUh?=
SK-MEL-3 MofRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\JOWlEPTB;MD6wOFgxOiEQvF2= Ml7iV2FPT0WU
MOLT-4 NF\leJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMES4NFMh|ryP Mkn6V2FPT0WU
PF-382 NULCUlZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\LZmRPUUN3ME2wMlA1QDJ4IN88US=> NInRdpVUSU6JRWK=
NUGC-3 M4i0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMES4Nlch|ryP M{jyfnNCVkeHUh?=
NCI-H1417 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMES4PUDPxE1? NY\KeZB3W0GQR1XS
COLO-205 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMES5NVkh|ryP NXnoNnhlW0GQR1XS
TE-441-T M1LBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHLTWM2OD1yLkC0PVMh|ryP Mk\PV2FPT0WU
MKN1 NHTJS3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDxd3BKSzVyPUCuNFQ6OyEQvF2= M3HHbXNCVkeHUh?=
UM-UC-3 M2CybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH6ZYZtUUN3ME2wMlA1QTVizszN MYPTRW5ITVJ?
SF126 MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfFTWM2OD1yLkC1NFEh|ryP MnjNV2FPT0WU
LB1047-RCC NYL1XZd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfhfVhKSzVyPUCuNFUxOzFizszN NYKzPYpQW0GQR1XS
A253 M33wRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTOc4FKSzVyPUCuNFUxPTJizszN NXX6SpYxW0GQR1XS
NCI-H1963 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7DO4RHUUN3ME2wMlA2OTd4IN88US=> NV7sdGY{W0GQR1XS
VM-CUB-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\YW2ZKSzVyPUCuNFU{OTFizszN MnLkV2FPT0WU
T-24 NXj2TmVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnnbG1KSzVyPUCuNFU{QDRizszN NYnwNVVLW0GQR1XS
K-562 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnEXFJPUUN3ME2wMlA2Ozh5IN88US=> NELNO4FUSU6JRWK=
ARH-77 M4DpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMEWzPVUh|ryP M3npRXNCVkeHUh?=
CA46 M4P3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD1TWM2OD1yLkC1OFMh|ryP MkPEV2FPT0WU
HCC70 M{D3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjISWRyUUN3ME2wMlA2PDV{IN88US=> NFvQSIRUSU6JRWK=
ST486 NHHqZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTHTWM2OD1yLkC1OVI2KM7:TR?= MWjTRW5ITVJ?
COLO-741 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIKzfVhKSzVyPUCuNFU2OzFizszN M4CxVXNCVkeHUh?=
SK-PN-DW NEjDWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XJfGlEPTB;MD6wOVU5QCEQvF2= M13qU3NCVkeHUh?=
BL-41 M1jUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEW1PVYh|ryP NYL4R4dQW0GQR1XS
D-263MG NXz0eoRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HIXmlEPTB;MD6wOVY5OyEQvF2= NFXX[3dUSU6JRWK=
KE-37 NITybmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4L0XmlEPTB;MD6wOVY5OyEQvF2= MYXTRW5ITVJ?
LU-134-A Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEW3NVUh|ryP NHnLcHZUSU6JRWK=
HCC2157 MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlraTWM2OD1yLkC1O|M{KM7:TR?= NUfmXlF{W0GQR1XS
GAK NUPKO45PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFriXpZKSzVyPUCuNFU4OzRizszN Mk\hV2FPT0WU
IST-SL2 M1ziUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly4TWM2OD1yLkC1O|Q{KM7:TR?= MmLPV2FPT0WU
KMOE-2 MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEW3OFkh|ryP MY\TRW5ITVJ?
SW1573 NGja[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLVVoRKSzVyPUCuNFU5ODJizszN M{\j[nNCVkeHUh?=
SCC-9 NHPyTIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEW4O{DPxE1? NXXXS3NzW0GQR1XS
MDA-MB-361 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoOyTWM2OD1yLkC1PFczKM7:TR?= MYDTRW5ITVJ?
BHT-101 NF\xSI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXmTWM2OD1yLkC1PFc3KM7:TR?= MmP2V2FPT0WU
NCI-H1770 M3rCUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17MdGlEPTB;MD6wOVg4QSEQvF2= MXLTRW5ITVJ?
UACC-893 NXntco9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz3TWM2OD1yLkC1PFk3KM7:TR?= NEm2SXpUSU6JRWK=
NCI-H226 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC3dGd7UUN3ME2wMlA2QTh6IN88US=> M{XITnNCVkeHUh?=
HLE MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwME[wPFIh|ryP NEjRS3VUSU6JRWK=
NCI-H1703 NUniZVRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPnTIVKSzVyPUCuNFYyPzhizszN M2jje3NCVkeHUh?=
KURAMOCHI M1LLZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHyWlAyUUN3ME2wMlA3OTh7IN88US=> MVzTRW5ITVJ?
RH-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwME[yN{DPxE1? M3PpRXNCVkeHUh?=
DSH1 Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\QSmlEPTB;MD6wOlI4KM7:TR?= MmHyV2FPT0WU
CAMA-1 MoiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlKxTWM2OD1yLkC2N|A{KM7:TR?= MXLTRW5ITVJ?
NCI-H1437 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGWzeHNKSzVyPUCuNFY{OjhizszN M17x[nNCVkeHUh?=
HuP-T4 NUK1VXo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPhN49WUUN3ME2wMlA3PTh4IN88US=> MU\TRW5ITVJ?
HCT-15 NHjkfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zFVGlEPTB;MD6wOlU6PyEQvF2= NXizPWFVW0GQR1XS
NCCIT MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC4TWM2OD1yLkC2OlA1KM7:TR?= MVzTRW5ITVJ?
BOKU NVTQZoszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj6d4dKSzVyPUCuNFY3PzRizszN MkTFV2FPT0WU
FADU NFzzdVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwME[3OFUh|ryP NULCe3NHW0GQR1XS
SUP-T1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwME[3OkDPxE1? NVXLSWR[W0GQR1XS
L-363 M1;WZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjNPW1KSzVyPUCuNFY6ODFizszN MWHTRW5ITVJ?
KNS-81-FD NGjqNFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwME[5NVgh|ryP M1LwUnNCVkeHUh?=
SU-DHL-1 NYO2fHBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG4S5l2UUN3ME2wMlA3QTJizszN MnHuV2FPT0WU
HuH-7 NXPQ[4pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\RVHhKSzVyPUCuNFcxOzVizszN MWnTRW5ITVJ?
BT-474 NIfGeVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\0emFNUUN3ME2wMlA4ODZzIN88US=> NFfyNWhUSU6JRWK=
CAPAN-1 NEHadWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\MU2lEPTB;MD6wO|E1OyEQvF2= M4Dib3NCVkeHUh?=
HEC-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTYSIM3UUN3ME2wMlA4OTZzIN88US=> M{XjXHNCVkeHUh?=
NOMO-1 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrvVYhOUUN3ME2wMlA4OTd{IN88US=> NYn4ZpE6W0GQR1XS
KM-H2 MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHV[4FoUUN3ME2wMlA4OjRzIN88US=> NIfKTWVUSU6JRWK=
EB2 MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nR[GlEPTB;MD6wO|I5PSEQvF2= MojRV2FPT0WU
LU-99A MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEeyPFch|ryP MmfKV2FPT0WU
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SK-MEL-28 NGPKUVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJwMUiwPVgh|ryP NXewdGQ2W0GQR1XS
EM-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITG[oRKSzVyPUKuNlAzQTNizszN M2fpb3NCVkeHUh?=
Mewo NX\u[|JnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTJfYpHUUN3ME2yMlIzOjZ3IN88US=> M1W1WXNCVkeHUh?=
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CAL-54 MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LUb2lEPTB;Mj6yOlc6PSEQvF2= NIHy[Y9USU6JRWK=
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DG-75 MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPhZ5hKSzVyPUKuOFg2PzZizszN NFjIOJRUSU6JRWK=
HCC1143 NEXDeYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH62dJdKSzVyPUKuOVA3PThizszN MorDV2FPT0WU
FTC-133 M3zhWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET6OItKSzVyPUKuOVM3QDlizszN NWD3OpRYW0GQR1XS
AsPC-1 MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfoNZEzUUN3ME2yMlU{QTJ7IN88US=> NFfUcHlUSU6JRWK=
NCI-H889 NFOwPJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJwNU[3NFYh|ryP M{LjNHNCVkeHUh?=
HT55 Mnq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXROllKSzVyPUKuOlIxOTlizszN NVnZfI5oW0GQR1XS
UMC-11 NHnzW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXVZmJKSzVyPUKuO|g4OTVizszN MXrTRW5ITVJ?
P12-ICHIKAWA MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELJcmpKSzVyPUKuPFIxPDZizszN MnnIV2FPT0WU
HCC1395 NUD0fGZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlizTWM2OD1{Lkm4OlAzKM7:TR?= M1TlRXNCVkeHUh?=
D-283MED NWKzWllDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLYTWM2OD1|LkG4PVM4KM7:TR?= NV\2TXRJW0GQR1XS
COLO-800 NVTXSYxwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:zfWlEPTB;Mz6zN|g6PyEQvF2= MUnTRW5ITVJ?
MFM-223 NW\TeotbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfOSGVKSzVyPUOuN|YxQTdizszN NXz1bnJyW0GQR1XS
TE-5 M1Ww[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnhVpNVUUN3ME20MlU3OTR5IN88US=> NGLBdnNUSU6JRWK=
NCI-H209 M33ydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTRwN{i1O|Ih|ryP MkTyV2FPT0WU
SiHa NX\BbIRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jsXmlEPTB;ND65OVIxOyEQvF2= Mn;yV2FPT0WU
NCI-H1395 NX7mXnFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnaOIJKSzVyPUWuNVA3OzNizszN NGLRcIlUSU6JRWK=
A498 MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjRTWM2OD13LkKxNlUyKM7:TR?= MoLXV2FPT0WU
ES5 NX;kNolCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX0NllKSzVyPUWuOlEyPzhizszN NYD0ZpdzW0GQR1XS
MDA-MB-157 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu5W|RKSzVyPUWuOlY1PDNizszN MXLTRW5ITVJ?
NCI-H1623 NV32UpZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqwNlBKSzVyPUWuPFM2PTZizszN M4nwPHNCVkeHUh?=
RPMI-8866 NVvuNJBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTVwOES3PVIh|ryP MluxV2FPT0WU
LC-1F NWrYUpNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;DS|hrUUN3ME22MlA6OjlzIN88US=> MmDhV2FPT0WU
TCCSUP NVjEemRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:yZ|ZKSzVyPU[uOlA{PDlizszN NXnRPVV7W0GQR1XS
TT MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRThwM{OwNFkh|ryP NGfvTXdUSU6JRWK=
NCI-H1838 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRThwNUG3N|Eh|ryP MXXTRW5ITVJ?
NCI-H322M MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\YR5hKSzVyPUmuNVYzQDFizszN NXfU[oxOW0GQR1XS
NCI-H187 NHH2TpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T4fmlEPTB;OT61NVg{PSEQvF2= M4riVHNCVkeHUh?=
SBC-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nPOGlEPTB;OT65N|Y2PiEQvF2= MkH2V2FPT0WU
SCC-3 MonQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvBeZBKSzVyPUGwMlU3PzlizszN NYGyNItmW0GQR1XS
SW948 NITVOnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTFyLke1NVEh|ryP Ml;uV2FPT0WU
CPC-N M3eyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTFzLkCwO{DPxE1? MlzPV2FPT0WU
TGBC24TKB NUW0cW5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG2ZnJKSzVyPUGzMlUzQSEQvF2= MnS5V2FPT0WU
NCI-H2452 NV72fmg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTF2LkezJO69VQ>? NXnRNWo{W0GQR1XS
Hs-578-T M1;sPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTF6LkW3OVkh|ryP MkTXV2FPT0WU
DV-90 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTF6Lkm5OFUh|ryP NVnVNVZ[W0GQR1XS
NCI-H1563 NV\1NotLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTF7Lke4PFgh|ryP M2XWdnNCVkeHUh?=
SW780 NUfVeVl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO5clRKSzVyPUKxMlE{OThizszN NVzCe497W0GQR1XS
NCI-H345 M3rZRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;EUWlKSzVyPUKxMlg4PzlizszN M1;wRXNCVkeHUh?=
LB771-HNC NEPHNIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvNTWM2OD1{Mj60PFE{KM7:TR?= NHXpdZdUSU6JRWK=
RT4 MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJ|LkOyPFIh|ryP NHv0V|NUSU6JRWK=
NCI-H82 NW\0SmV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7IO5pnUUN3ME2yN{42PTJ4IN88US=> MX;TRW5ITVJ?
NCI-H524 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfKTWM2OD1{ND6zPFEzKM7:TR?= M1n2c3NCVkeHUh?=
SNU-C1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIKzRYdKSzVyPUK0MlkyODVizszN MXvTRW5ITVJ?
NCI-SNU-16 NWC1T5BET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT6TWM2OD12OD6zNVQzKM7:TR?= MYDTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

細胞アッセイ: [1]

細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

動物実験: [3]

動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
製剤 In DMSO and diluted in sterile saline/Tween 20
投薬量 50 mg/kg
投与方法 Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Luminespib (AUY-922, NVP-AUY922) SDF
分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管 2年-20℃
6月-80℃in solvent
別名 VER-52296
溶解度 (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
エタノール 31 mg/mL (66.58 mM)
<1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

カスタマーフィードバック (3)


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Rating
Source , , Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck
Method Immunostaining
Cell Lines U2OS_exo cells
Concentrations 4 µM
Incubation Time 20 h
Results AUY922 blocked nuclear migration of RelA/p50 induced by TNFα in a dose-dependent manner, consistent with the notion that Hsp90 is required for activation of the NF-κB pathway.

Click to enlarge
Rating
Source J Biol Chem, 2013, 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck
Method Western blot
Cell Lines 293T cells
Concentrations 1 uM
Incubation Time 16 h
Results Treatment of cellswith each of these HSP90 inhibitors (17-AAG, SNX-5422, or NVP-AUY922) caused a significant reduction in TSSK1, -2, -4, and -6 in the cells.

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Rating
Source 2011, Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck
Method Western blot
Cell Lines BT474 breast cancer cell line
Concentrations 1.0 ± 0.1 nM
Incubation Time 8/24 h
Results Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922.

文献中の引用 (23)

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Related HSP (e.g. HSP90) 阻害剤

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.

  • KNK437

    KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

  • VER155008

    VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

  • FRAX597

    FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.

  • 17-AAG (Tanespimycin)

    17-AAG (Tanespimycin)は、5nMのIC50による強力な熱ショックタンパク質90(Hsp90)阻害剤です。

    Features:Displays very low toxicity toward normal cells.

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090)は独特な triazolone-containing Hsp90阻害剤、 IC50 が4 nM となる.

  • 17-DMAG (Alvespimycin) HCl

    17-DMAG (Alvespimycin) HClは、62nMのIC50による強力なHsp90阻害剤です。

    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    ノーカット二量体Hsp90またはN末端領域Hsp90と結合している間、Geldanamycinは1.2のμMまたは0.78のμMによるKdによる天然既存のHsp90阻害剤です。

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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