Luminespib (AUY-922, NVP-AUY922) 化学構造
分子量: 465.54

高品質保証

カスタマーフィードバック(3)

MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野
  • Luminespib (AUY-922, NVP-AUY922)のメカニズム

製品の説明

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。
ターゲット HSP90α HSP90β
IC50 13 nM 21 nM [1]
In vitro試験 NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMK MmTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvDUJFKSzVyPUCuNFAxOTJ3IN88US=> NGfNOVhUSU6JRWK=
MV-4-11 MlnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;hTWM2OD1yLkCwNFU2QCEQvF2= MXnTRW5ITVJ?
NALM-6 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvSTWM2OD1yLkCwNFg1OiEQvF2= NH7JcIFUSU6JRWK=
HOS NVvZR251T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXmTWM2OD1yLkCwNVM5KM7:TR?= MknSV2FPT0WU
HT-144 NGjxXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;YcGFKSzVyPUCuNFAyPTVizszN M33RSXNCVkeHUh?=
SW1710 M3fDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHGTWM2OD1yLkCwNVg3KM7:TR?= M1HFeHNCVkeHUh?=
TE-8 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe4TFBKSzVyPUCuNFAzOzdizszN Ml71V2FPT0WU
ES1 M13XXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrhU4JKSzVyPUCuNFAzPjZizszN M2HLSHNCVkeHUh?=
CCF-STTG1 M3fpSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TtTWlEPTB;MD6wNFI6PyEQvF2= NEjaTGRUSU6JRWK=
PSN1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfYTWM2OD1yLkCwN|E5KM7:TR?= NUHIXlRyW0GQR1XS
CAL-51 M4P3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf2fGhPUUN3ME2wMlAxOzJ3IN88US=> MYDTRW5ITVJ?
MCF7 M3HCT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMECzN|Uh|ryP NXm4UYdbW0GQR1XS
SK-HEP-1 M1Pvemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[4eno5UUN3ME2wMlAxOzN4IN88US=> NX7mOlhzW0GQR1XS
LCLC-103H Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3tTWM2OD1yLkCwOFMh|ryP Mli0V2FPT0WU
HMV-II NYf0THA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTqTWM2OD1yLkCwOFQ6KM7:TR?= NFfleldUSU6JRWK=
MES-SA M1GwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPw[4NQUUN3ME2wMlAxPDV{IN88US=> M4O0UnNCVkeHUh?=
SK-LMS-1 NFPIcXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPTToRKSzVyPUCuNFA1PThizszN MmHHV2FPT0WU
639-V NIC1VIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj2e2hNUUN3ME2wMlAxPDh3IN88US=> NUXFOZFLW0GQR1XS
SIG-M5 M1i2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfRTWM2OD1yLkCwOFg6KM7:TR?= NUHhOGRtW0GQR1XS
LOUCY M4f0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j6cGlEPTB;MD6wNFUxPSEQvF2= MoPsV2FPT0WU
HSC-2 MmXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEC1NVgh|ryP NHXYPZZUSU6JRWK=
EW-13 NXvKWYVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33lPWlEPTB;MD6wNFUyQCEQvF2= NX24dXdxW0GQR1XS
RT-112 MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7qTWM2OD1yLkCwOVM2KM7:TR?= MnfJV2FPT0WU
NKM-1 NFvMT2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPrTWM2OD1yLkCwOVQ4KM7:TR?= M2mzTXNCVkeHUh?=
KYSE-180 NGnDdlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXZTWM2OD1yLkCwOVg3KM7:TR?= NFX0UFdUSU6JRWK=
SW1783 M2XjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEC1PVEh|ryP M3OzXHNCVkeHUh?=
A431 NWTtWYdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEC2NFch|ryP MkDkV2FPT0WU
SK-OV-3 M3zUSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLaTZIyUUN3ME2wMlAxPjNizszN NFy0UFJUSU6JRWK=
RPMI-7951 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEC2N|Eh|ryP NELndnlUSU6JRWK=
Capan-2 NIW1UpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorETWM2OD1yLkCwOlM5KM7:TR?= M2LUNXNCVkeHUh?=
HSC-3 M3LVSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X1T2lEPTB;MD6wNFY1OSEQvF2= NWHve|lnW0GQR1XS
786-0 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjyTWM2OD1yLkCwOlY{KM7:TR?= NVW0PG9QW0GQR1XS
Daoy MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nncGlEPTB;MD6wNFY6PSEQvF2= M2jodnNCVkeHUh?=
KGN MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vBSWlEPTB;MD6wNFcxOyEQvF2= M{D6PXNCVkeHUh?=
EW-16 M4jBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrxTWM2OD1yLkCwO|Q6KM7:TR?= NFzCWYxUSU6JRWK=
EW-7 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TGcWlEPTB;MD6wNFc2PCEQvF2= NXP3UIFrW0GQR1XS
IGROV-1 NYPBS2wzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnvd4ttUUN3ME2wMlAxQDF2IN88US=> NH3DOmpUSU6JRWK=
8505C M3Prd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDsTWM2OD1yLkCwPFIyKM7:TR?= M2P6enNCVkeHUh?=
RKO NWCyc4RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzVXIZKSzVyPUCuNFA5OjZizszN NEHkWItUSU6JRWK=
GDM-1 NFnXNIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEC4OEDPxE1? MnHmV2FPT0WU
IST-MEL1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEC4OVIh|ryP NITld|BUSU6JRWK=
RPMI-6666 M3;YWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrLTWM2OD1yLkCwPFUzKM7:TR?= NFrB[olUSU6JRWK=
SNG-M MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMEC4OVYh|ryP MlnXV2FPT0WU
KS-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjNfm9HUUN3ME2wMlAxQDV7IN88US=> MWjTRW5ITVJ?
RXF393 M4LEOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEC4OkDPxE1? MnG5V2FPT0WU
CAL-12T M2Tib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHpTWM2OD1yLkCwPVIzKM7:TR?= M1Xzb3NCVkeHUh?=
BFTC-905 M3e5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW4TWM2OD1yLkCwPVM5KM7:TR?= MVXTRW5ITVJ?
SK-MES-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEC5OFUh|ryP M2nsfXNCVkeHUh?=
BB30-HNC M2PlbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETJ[mhKSzVyPUCuNFA6PTJizszN NFW3d5FUSU6JRWK=
AN3-CA MkftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP3VHRKSzVyPUCuNFExOTdizszN M{nl[3NCVkeHUh?=
EFO-27 NGfHSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M373OWlEPTB;MD6wNVAyPyEQvF2= M4\XdXNCVkeHUh?=
G-401 NW\yNZFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\5PWlEPTB;MD6wNVAzPSEQvF2= M4PYe3NCVkeHUh?=
BPH-1 NUX4cWR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL2TWM2OD1yLkCxNFMh|ryP NHXMZYVUSU6JRWK=
NCI-H727 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHlTWM2OD1yLkCxNFMh|ryP MU\TRW5ITVJ?
SNU-423 M{\QW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLibXBKSzVyPUCuNFExPTNizszN MmrKV2FPT0WU
KYSE-270 NXHFbXV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXsTWM2OD1yLkCxNFU6KM7:TR?= MV\TRW5ITVJ?
AGS MnHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL3dGhzUUN3ME2wMlAyODZzIN88US=> NEPqOYtUSU6JRWK=
NCI-H2228 NG\VNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTsbGZFUUN3ME2wMlAyODZ2IN88US=> M{XIbnNCVkeHUh?=
SW954 NYH5fYNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r0XWlEPTB;MD6wNVA4OSEQvF2= M{TxWXNCVkeHUh?=
769-P NEDwV|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2focmlEPTB;MD6wNVA4OyEQvF2= MUPTRW5ITVJ?
BB49-HNC M3;QN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIj1O29KSzVyPUCuNFExPzdizszN M2TPR3NCVkeHUh?=
IA-LM MkLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq1XmlKSzVyPUCuNFExQDZizszN M4XUTXNCVkeHUh?=
NB69 NXiySYduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LCemlEPTB;MD6wNVExOiEQvF2= M2L2R3NCVkeHUh?=
C8166 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXETWM2OD1yLkCxNVI6KM7:TR?= M2DieHNCVkeHUh?=
NCI-H1299 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEGxOVQh|ryP NXPGbJQ5W0GQR1XS
YKG-1 M3O1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvYTWM2OD1yLkCxNVYh|ryP MUHTRW5ITVJ?
PANC-03-27 MoiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXkeGlMUUN3ME2wMlAyOTZ{IN88US=> NFLwWmNUSU6JRWK=
YT MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\OeZBKSzVyPUCuNFEyPzlizszN NWC2VmF{W0GQR1XS
CAL-85-1 MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLaSml1UUN3ME2wMlAyOTl{IN88US=> NXnrSZREW0GQR1XS
GT3TKB NVfiNYVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7sboFmUUN3ME2wMlAyOjB{IN88US=> NXzyc|JzW0GQR1XS
BB65-RCC M1HSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEGyNFQh|ryP MkPNV2FPT0WU
ES6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEGyOlEh|ryP Mmi5V2FPT0WU
MHH-ES-1 NVO2Z|FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPxb5RKSzVyPUCuNFEzPjNizszN M1XmUXNCVkeHUh?=
QIMR-WIL M4\oSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDaTWM2OD1yLkCxNlY6KM7:TR?= NWD5Z3FEW0GQR1XS
SNU-C2B M2\SXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEGyO|Ih|ryP NUDVcpY1W0GQR1XS
OCI-AML2 NWXzbmU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HacmlEPTB;MD6wNVI5OSEQvF2= NEX6RZNUSU6JRWK=
DU-145 M37xUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEGyPUDPxE1? NVrrXJlEW0GQR1XS
SW982 MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDHTWM2OD1yLkCxNlk{KM7:TR?= M2PzS3NCVkeHUh?=
MFH-ino NH60fWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEGyPVMh|ryP MWDTRW5ITVJ?
A427 NEXnS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XwVGlEPTB;MD6wNVI6QSEQvF2= MlvlV2FPT0WU
LCLC-97TM1 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnrSmRYUUN3ME2wMlAyOyEQvF2= M1m1cHNCVkeHUh?=
AM-38 M1LTV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrCO|ZrUUN3ME2wMlAyOzB{IN88US=> M1XHUnNCVkeHUh?=
K5 NG\1S|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PhbWlEPTB;MD6wNVMxQCEQvF2= NX65Z2ZkW0GQR1XS
T84 MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMEGzN|Eh|ryP MmPvV2FPT0WU
TE-15 NXjNbmxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:1d2lEPTB;MD6wNVM{PiEQvF2= MWrTRW5ITVJ?
NCI-H460 M4T3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;0N4hKSzVyPUCuNFE{OzZizszN NVHHXWVnW0GQR1XS
NTERA-S-cl-D1 Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nrWmlEPTB;MD6wNVM{QSEQvF2= M3:2PHNCVkeHUh?=
KYSE-450 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkexTWM2OD1yLkCxN|Q6KM7:TR?= NYPLeI93W0GQR1XS
H4 M3;Dbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfa[5NbUUN3ME2wMlAyOzZ4IN88US=> NV:5fpc3W0GQR1XS
LC-2-ad MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jIRWlEPTB;MD6wNVM4KM7:TR?= MlrRV2FPT0WU
GAMG NEDZVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LPdWlEPTB;MD6wNVM4OSEQvF2= M4T4V3NCVkeHUh?=
TK10 M3T3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFT3eFdKSzVyPUCuNFE{QDJizszN NV3yd2Q6W0GQR1XS
NCI-H2122 NGjkVmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoG1TWM2OD1yLkCxN|g1KM7:TR?= MojlV2FPT0WU
KM12 MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEGzPVkh|ryP NET1XYZUSU6JRWK=
CAL-39 NXf4NJViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17OOGlEPTB;MD6wNVQzKM7:TR?= M4XOWXNCVkeHUh?=
RPMI-2650 NVfSSGNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXkd49KSzVyPUCuNFE1OzJizszN NFjNV|hUSU6JRWK=
KYSE-510 NV3yZ2d5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\WdY1EUUN3ME2wMlAyPDR{IN88US=> M3WyO3NCVkeHUh?=
KALS-1 NIXORZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK2U2lKSzVyPUCuNFE1PjZizszN MmjPV2FPT0WU
NCI-H1648 NFrue5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX1SHlpUUN3ME2wMlAyPDl7IN88US=> NHz3NIVUSU6JRWK=
ES4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M324fmlEPTB;MD6wNVUxOiEQvF2= MUPTRW5ITVJ?
C-33-A MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEG1NFkh|ryP MnnlV2FPT0WU
MIA-PaCa-2 NI[2dnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe5TWM2OD1yLkCxOVA6KM7:TR?= MWfTRW5ITVJ?
Becker M4HScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEG1NVQh|ryP M2jGcnNCVkeHUh?=
HOP-62 M2fZdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEG1OFIh|ryP M4DEenNCVkeHUh?=
TE-1 M4DXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVS4OXN3UUN3ME2wMlAyPThzIN88US=> MlOxV2FPT0WU
KYSE-410 NVS0S5pHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnKxTWM2OD1yLkCxOVg3KM7:TR?= NIPnZoJUSU6JRWK=
NOS-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvwN5c4UUN3ME2wMlAyPTl|IN88US=> NUf3NI9GW0GQR1XS
MEL-HO NVPZU2FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17scWlEPTB;MD6wNVY1OyEQvF2= NXXNSm5zW0GQR1XS
NCI-H1650 MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDTTWM2OD1yLkCxOlQ3KM7:TR?= M4j1UnNCVkeHUh?=
VMRC-RCZ MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe2To5KSzVyPUCuNFE3PTFizszN NV\1c2d5W0GQR1XS
HuP-T3 M{LlPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2CzTGlEPTB;MD6wNVY2OyEQvF2= M3;iWnNCVkeHUh?=
ACN NXyzdGpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHqbVZKUUN3ME2wMlAyPjV5IN88US=> MXfTRW5ITVJ?
MEL-JUSO M2qyfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLVTWM2OD1yLkCxOlgyKM7:TR?= MlvvV2FPT0WU
HT-1197 MmXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XUc2lEPTB;MD6wNVY5PSEQvF2= NI\PO2FUSU6JRWK=
NCI-H2030 M1\mZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfBTWM2OD1yLkCxOlk4KM7:TR?= M3rMTnNCVkeHUh?=
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NCI-H2009 NIjtNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnjTWM2OD1yLkCyO|Yh|ryP MnHLV2FPT0WU
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NCI-H2087 NVrHWJN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzSZZl2UUN3ME2wMlA{Ojh7IN88US=> MlrXV2FPT0WU
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BC-1 NGftRZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz3UFRKSzVyPUCuNFM{PjdizszN MoXMV2FPT0WU
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BL-70 NVzDTpU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzNZ5d[UUN3ME2wMlA{Ozh7IN88US=> M2nTW3NCVkeHUh?=
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BV-173 NWXz[4Z6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHZWHVpUUN3ME2wMlA{PDJ4IN88US=> M3z2WnNCVkeHUh?=
DMS-273 M3O2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LG[GlEPTB;MD6wN|Q4QSEQvF2= MkLTV2FPT0WU
22RV1 MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PrZmlEPTB;MD6wN|UxPyEQvF2= MmTrV2FPT0WU
ES8 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEO1N|gh|ryP Mm\lV2FPT0WU
KYSE-150 M1X4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfXcppYUUN3ME2wMlA{PjB6IN88US=> NILpVZZUSU6JRWK=
HCC1569 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjPTWM2OD1yLkCzOlA5KM7:TR?= NEfWWGFUSU6JRWK=
NB5 NGS1d5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGSzVFNKSzVyPUCuNFM3OTNizszN MnP2V2FPT0WU
G-402 NWe2NHpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPXOmNqUUN3ME2wMlA{PjF2IN88US=> M2TYR3NCVkeHUh?=
NCI-H1693 MomyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLWPWlGUUN3ME2wMlA{PjF5IN88US=> NX\EUYtoW0GQR1XS
LB2241-RCC NWPBPXA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTMTWM2OD1yLkCzOlQzKM7:TR?= MlG0V2FPT0WU
KP-4 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fGNmlEPTB;MD6wN|Y3OyEQvF2= M4\wfHNCVkeHUh?=
ML-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEO2O|Eh|ryP M{jNPXNCVkeHUh?=
KU812 NV3jUVlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorkTWM2OD1yLkCzOlg1KM7:TR?= M2\oRXNCVkeHUh?=
LS-411N M33aN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorITWM2OD1yLkCzO|MyKM7:TR?= M4\lTnNCVkeHUh?=
OAW-42 Mm[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWwXXpKSzVyPUCuNFM4PDdizszN Ml:yV2FPT0WU
HCC38 NUC4VZNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMEO3O|Eh|ryP NHLY[mVUSU6JRWK=
Ca-Ski MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvVbZYxUUN3ME2wMlA{Pzh2IN88US=> NHrPdGFUSU6JRWK=
Calu-3 M1fITmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jXRmlEPTB;MD6wN|c5QSEQvF2= MlnqV2FPT0WU
KYSE-70 NVnlN|FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO4TWM2OD1yLkCzPFEzKM7:TR?= MWfTRW5ITVJ?
D-392MG MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDyT5lyUUN3ME2wMlA{QDR{IN88US=> M2HkT3NCVkeHUh?=
OVCAR-4 NFLwVXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEO4OVgh|ryP MlK2V2FPT0WU
Detroit562 MoLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\tb29NUUN3ME2wMlA{QDd{IN88US=> M{PxNHNCVkeHUh?=
HEL Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\oTlF3UUN3ME2wMlA{QDlzIN88US=> NFLTRmtUSU6JRWK=
MONO-MAC-6 NXnaNoRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr4dYRRUUN3ME2wMlA{QDl|IN88US=> MXrTRW5ITVJ?
LoVo NVO1[pRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG5TWM2OD1yLkCzPVM{KM7:TR?= MljmV2FPT0WU
U-2-OS NUK3VGY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvTb3Q3UUN3ME2wMlA{QTN3IN88US=> NUGzTHN3W0GQR1XS
A172 NVi2dmFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEO5OUDPxE1? NIjGPYtUSU6JRWK=
OCUB-M M2G2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHjS3BKSzVyPUCuNFM6PjFizszN M1zkeXNCVkeHUh?=
SW48 NEXJN|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnsTWM2OD1yLkC0NFMyKM7:TR?= Ml;RV2FPT0WU
HC-1 M3vl[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonOTWM2OD1yLkC0NFY6KM7:TR?= M2DneHNCVkeHUh?=
KOSC-2 NH\IS4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Th[GlEPTB;MD6wOFEyKM7:TR?= M{XkOHNCVkeHUh?=
HDLM-2 NVzGOHBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3VNlRsUUN3ME2wMlA1OTF2IN88US=> NEPhcmZUSU6JRWK=
CTV-1 MkH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S5c2lEPTB;MD6wOFEyPiEQvF2= MXPTRW5ITVJ?
SH-4 MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi4UmNKSzVyPUCuNFQyPDFizszN Mm\LV2FPT0WU
SW756 MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLCTWM2OD1yLkC0NVU4KM7:TR?= MXHTRW5ITVJ?
GCT NFHnT2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\VRnZKSzVyPUCuNFQyPjFizszN NWnhTW5JW0GQR1XS
CHL-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3YTWM2OD1yLkC0NVY6KM7:TR?= MXjTRW5ITVJ?
LAMA-84 M1iyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMESxO|Eh|ryP MUTTRW5ITVJ?
LS-1034 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LVdWlEPTB;MD6wOFE6OSEQvF2= MVXTRW5ITVJ?
NCI-H358 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XlTGlEPTB;MD6wOFIyOiEQvF2= M3S0THNCVkeHUh?=
NB13 NV3kdm13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHJ[VA5UUN3ME2wMlA1OjJ5IN88US=> NGL0Om9USU6JRWK=
TE-9 MkHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPDeocxUUN3ME2wMlA1OjN5IN88US=> M1HrN3NCVkeHUh?=
OE33 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPnUWVyUUN3ME2wMlA1OjRzIN88US=> MnLSV2FPT0WU
CAL-120 M2XXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMESyOFEh|ryP NEDtWY1USU6JRWK=
DJM-1 NG\6[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\QZ5RKSzVyPUCuNFQzPzJizszN NF;xUllUSU6JRWK=
SK-MEL-24 M{T1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMESyPFMh|ryP NFPFSGFUSU6JRWK=
VA-ES-BJ MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTrTWM2OD1yLkC0NlkzKM7:TR?= NFnPTVVUSU6JRWK=
MMAC-SF NUfXVI1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v5eGlEPTB;MD6wOFI6PyEQvF2= NGTOclNUSU6JRWK=
MZ7-mel NXq3eJpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XIPWlEPTB;MD6wOFM{KM7:TR?= NVSyN2FUW0GQR1XS
BxPC-3 M4raemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXGOVZKSzVyPUCuNFQ{PDFizszN NWfxZWxyW0GQR1XS
HT-29 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn1VplKUUN3ME2wMlA1OzV5IN88US=> NVTNUIp[W0GQR1XS
SK-MEL-30 MnG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[2N4VIUUN3ME2wMlA1OzZ{IN88US=> MV\TRW5ITVJ?
CAL-33 NEfONJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3yR|ZKSzVyPUCuNFQ{PzVizszN MYPTRW5ITVJ?
COLO-680N M3yxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[wTWM2OD1yLkC0OFA4KM7:TR?= M4HubnNCVkeHUh?=
NH-12 Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTzOHBKSzVyPUCuNFQ1PCEQvF2= MmnVV2FPT0WU
HCC1937 M4TZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMES0OVYh|ryP MXrTRW5ITVJ?
IMR-5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMES0PUDPxE1? M{K0[3NCVkeHUh?=
MC-CAR NEHjcpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j6[mlEPTB;MD6wOFU3QSEQvF2= NVrDSFl[W0GQR1XS
NCI-H747 NFezUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMES1O{DPxE1? MnTNV2FPT0WU
NCI-H1792 NWrXe2NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMES1PFEh|ryP NHnrT3dUSU6JRWK=
SW13 MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMES1PUDPxE1? MnrZV2FPT0WU
MLMA M4fEV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMES2NFkh|ryP NXnaS5FvW0GQR1XS
U251 NEjwUlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjBd2tKSzVyPUCuNFQ4PjNizszN MoLwV2FPT0WU
U031 MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG1TWM2OD1yLkC0O|cyKM7:TR?= MVjTRW5ITVJ?
ME-180 NGT1WXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMES3PFIh|ryP MnP3V2FPT0WU
SK-MEL-3 NX;ZbWM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnZTWM2OD1yLkC0PFAzKM7:TR?= Mn71V2FPT0WU
MOLT-4 NF7oSnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HZb2lEPTB;MD6wOFgxOyEQvF2= NHLwWIdUSU6JRWK=
PF-382 NHXCdXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjWemNCUUN3ME2wMlA1QDJ4IN88US=> NUfPdHFNW0GQR1XS
NUGC-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXqTXBkUUN3ME2wMlA1QDJ5IN88US=> MYDTRW5ITVJ?
NCI-H1417 NGDHVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\aTWM2OD1yLkC0PFkh|ryP NYTISW5HW0GQR1XS
COLO-205 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmSyTWM2OD1yLkC0PVE6KM7:TR?= MWHTRW5ITVJ?
TE-441-T M3roSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXxW5B5UUN3ME2wMlA1QTNizszN MVHTRW5ITVJ?
MKN1 MmjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX0cotKSzVyPUCuNFQ6OyEQvF2= Mn3TV2FPT0WU
UM-UC-3 M2\ZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TXOWlEPTB;MD6wOFk2KM7:TR?= MYrTRW5ITVJ?
SF126 NHrE[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1GyU2lEPTB;MD6wOVAyKM7:TR?= NInYOHpUSU6JRWK=
LB1047-RCC NYPEelVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmm2TWM2OD1yLkC1NFMyKM7:TR?= M1;1UHNCVkeHUh?=
A253 NGnlR2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf2TWM2OD1yLkC1NFUzKM7:TR?= MXHTRW5ITVJ?
NCI-H1963 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGGwXlFKSzVyPUCuNFUyPzZizszN NW\IZ3k2W0GQR1XS
VM-CUB-1 MnPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLOTWM2OD1yLkC1N|EyKM7:TR?= M1HEVnNCVkeHUh?=
T-24 Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEWzPFQh|ryP M2qxbXNCVkeHUh?=
K-562 NWTkfYhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHqWpJKSzVyPUCuNFU{QDdizszN MV;TRW5ITVJ?
ARH-77 MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrhVWZKSzVyPUCuNFU{QTVizszN MnPWV2FPT0WU
CA46 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33rdmlEPTB;MD6wOVQ{KM7:TR?= M{HJWHNCVkeHUh?=
HCC70 M4\xVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjZTWM2OD1yLkC1OFUzKM7:TR?= NVTRWZNxW0GQR1XS
ST486 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7ENnFKSzVyPUCuNFU2OjVizszN NWOwWI8zW0GQR1XS
COLO-741 M1HjPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEW1N|Eh|ryP NF7jb2FUSU6JRWK=
SK-PN-DW M3X0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;xR5h[UUN3ME2wMlA2PTh6IN88US=> NIDlcnRUSU6JRWK=
BL-41 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX2cWZYUUN3ME2wMlA2PTl4IN88US=> NWDXNlZCW0GQR1XS
D-263MG NUnTdmVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DzcmlEPTB;MD6wOVY5OyEQvF2= MVfTRW5ITVJ?
KE-37 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zx[2lEPTB;MD6wOVY5OyEQvF2= NXjkXo1UW0GQR1XS
LU-134-A NFLJVVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHtU3JKSzVyPUCuNFU4OTVizszN MVPTRW5ITVJ?
HCC2157 MnvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLoeZp{UUN3ME2wMlA2PzN|IN88US=> M4LJSnNCVkeHUh?=
GAK NVrtVoU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4flUWlEPTB;MD6wOVc{PCEQvF2= M2jFT3NCVkeHUh?=
IST-SL2 M{HyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojDTWM2OD1yLkC1O|Q{KM7:TR?= MXTTRW5ITVJ?
KMOE-2 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEW3OFkh|ryP NHvT[ZNUSU6JRWK=
SW1573 NVzoU3ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnUTWM2OD1yLkC1PFAzKM7:TR?= MlTNV2FPT0WU
SCC-9 NUDkbZVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEW4O{DPxE1? MYrTRW5ITVJ?
MDA-MB-361 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\EZWlEPTB;MD6wOVg4OiEQvF2= MlXCV2FPT0WU
BHT-101 MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkKxTWM2OD1yLkC1PFc3KM7:TR?= M3K3UXNCVkeHUh?=
NCI-H1770 M2nUSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPsR|hIUUN3ME2wMlA2QDd7IN88US=> NUK2WVlxW0GQR1XS
UACC-893 MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XoN2lEPTB;MD6wOVg6PiEQvF2= NYTGfFk{W0GQR1XS
NCI-H226 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHBVoJKSzVyPUCuNFU6QDhizszN M3jYdnNCVkeHUh?=
HLE MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTTbJhjUUN3ME2wMlA3ODh{IN88US=> MoH6V2FPT0WU
NCI-H1703 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW3blRKSzVyPUCuNFYyPzhizszN NEHBO3JUSU6JRWK=
KURAMOCHI Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrF[olKSzVyPUCuNFYyQDlizszN NI\OSnNUSU6JRWK=
RH-1 Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorjTWM2OD1yLkC2NlMh|ryP NGL3bVZUSU6JRWK=
DSH1 NVzYdIY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XZ[2lEPTB;MD6wOlI4KM7:TR?= M1rXZXNCVkeHUh?=
CAMA-1 NXXGfYRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwME[zNFMh|ryP MVfTRW5ITVJ?
NCI-H1437 NFrKPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXETWM2OD1yLkC2N|I5KM7:TR?= NF7tcFNUSU6JRWK=
HuP-T4 NHn1TFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HpRmlEPTB;MD6wOlU5PiEQvF2= NVXMbG1JW0GQR1XS
HCT-15 NGm1TlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rRO2lEPTB;MD6wOlU6PyEQvF2= NVTLPYg6W0GQR1XS
NCCIT MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP6SI1KSzVyPUCuNFY3ODRizszN M4\Z[nNCVkeHUh?=
BOKU NEXMdVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwME[2O|Qh|ryP M{nvbHNCVkeHUh?=
FADU MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[0U5BKSzVyPUCuNFY4PDVizszN M37w[3NCVkeHUh?=
SUP-T1 M1rZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1GycmlEPTB;MD6wOlc3KM7:TR?= MVnTRW5ITVJ?
L-363 NETOeItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{H6OWlEPTB;MD6wOlkxOSEQvF2= MXPTRW5ITVJ?
KNS-81-FD MkP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDrWG9qUUN3ME2wMlA3QTF6IN88US=> M2nud3NCVkeHUh?=
SU-DHL-1 MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnhfoFKSzVyPUCuNFY6OiEQvF2= MnHNV2FPT0WU
HuH-7 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEewN|Uh|ryP NWPmRYhVW0GQR1XS
BT-474 M4TIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:zTWM2OD1yLkC3NFYyKM7:TR?= Mn\GV2FPT0WU
CAPAN-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:yVmlEPTB;MD6wO|E1OyEQvF2= Ml;iV2FPT0WU
HEC-1 NHzZeZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DDVWlEPTB;MD6wO|E3OSEQvF2= NEHzfGZUSU6JRWK=
NOMO-1 NEPkb49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i5WWlEPTB;MD6wO|E4OiEQvF2= NUW2O4RXW0GQR1XS
KM-H2 M1fXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoW3TWM2OD1yLkC3NlQyKM7:TR?= NHnNVHdUSU6JRWK=
EB2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XiSGlEPTB;MD6wO|I5PSEQvF2= MWnTRW5ITVJ?
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HuO-3N1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\EPW9bUUN3ME2xMlg{PDF{IN88US=> NI\YcYRUSU6JRWK=
NCI-H1793 NUG4eZVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z2cWlEPTB;MT64O|U6OyEQvF2= M1PHd3NCVkeHUh?=
Caov-3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnMTWM2OD1{LkCwOlI2KM7:TR?= MXnTRW5ITVJ?
JAR MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTNfVVKSzVyPUKuNFc6OiEQvF2= NIH3SYNUSU6JRWK=
SK-MEL-28 NETn[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHmUWFsUUN3ME2yMlE5ODl6IN88US=> MnHDV2FPT0WU
EM-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJwMkCyPVMh|ryP Ml:4V2FPT0WU
Mewo MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmOyTWM2OD1{LkKyNlY2KM7:TR?= M3PFXnNCVkeHUh?=
NCI-H720 NIDUXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHMfI1nUUN3ME2yMlI3PTh3IN88US=> NXTTdnpKW0GQR1XS
CAL-54 NILNXJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWqxSY9KUUN3ME2yMlI3Pzl3IN88US=> MX\TRW5ITVJ?
MC116 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJwM{[zPVch|ryP MmHTV2FPT0WU
DG-75 NWnKRZFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Pt[WlEPTB;Mj60PFU4PiEQvF2= M1TEcHNCVkeHUh?=
HCC1143 NHz0UXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3uVW5KSzVyPUKuOVA3PThizszN M{\xUnNCVkeHUh?=
FTC-133 NVzUPHUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJwNUO2PFkh|ryP M3GxUHNCVkeHUh?=
AsPC-1 NVrhWppbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEmzcHRKSzVyPUKuOVM6OjlizszN NF\QWpVUSU6JRWK=
NCI-H889 NVrBR3V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1raZ2lEPTB;Mj61OlcxPiEQvF2= NWDuN2FLW0GQR1XS
HT55 NXfoRXJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzFTWM2OD1{Lk[yNFE6KM7:TR?= MX;TRW5ITVJ?
UMC-11 NUfmT4FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjmfHlKSzVyPUKuO|g4OTVizszN M{W5UHNCVkeHUh?=
P12-ICHIKAWA MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrnZplwUUN3ME2yMlgzODR4IN88US=> NFL3NlJUSU6JRWK=
HCC1395 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLxOYljUUN3ME2yMlk5PjB{IN88US=> MYDTRW5ITVJ?
D-283MED NF6yZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTNwMUi5N|ch|ryP MXPTRW5ITVJ?
COLO-800 NX3SU4VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF2wcGRKSzVyPUOuN|M5QTdizszN MVrTRW5ITVJ?
MFM-223 NV7OdW5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTNwM{[wPVch|ryP Mnf3V2FPT0WU
TE-5 NWPJR3U1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\MNmlEPTB;ND61OlE1PyEQvF2= M1viTXNCVkeHUh?=
NCI-H209 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\re2NKSzVyPUSuO|g2PzJizszN NILX[3BUSU6JRWK=
SiHa NIKzb4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDSTWM2OD12Lkm1NlA{KM7:TR?= M1rzSXNCVkeHUh?=
NCI-H1395 M17aVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\WUI9{UUN3ME21MlExPjN|IN88US=> M4XrOHNCVkeHUh?=
A498 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTWTWM2OD13LkKxNlUyKM7:TR?= MV7TRW5ITVJ?
ES5 NIi0U3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHLXG5CUUN3ME21MlYyOTd6IN88US=> M2SxeHNCVkeHUh?=
MDA-MB-157 NHfyPYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LKS2lEPTB;NT62OlQ1OyEQvF2= Ml7MV2FPT0WU
NCI-H1623 M{\4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTVwOEO1OVYh|ryP MYrTRW5ITVJ?
RPMI-8866 NHmxVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf5TWM2OD13Lki0O|kzKM7:TR?= MVLTRW5ITVJ?
LC-1F M4\0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzvR4tKSzVyPU[uNFkzQTFizszN NITROIRUSU6JRWK=
TCCSUP MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTZwNkCzOFkh|ryP NXrw[4c3W0GQR1XS
TT M2TZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TLeWlEPTB;OD6zN|AxQSEQvF2= MUXTRW5ITVJ?
NCI-H1838 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4D3WmlEPTB;OD61NVc{OSEQvF2= NVPtd4x[W0GQR1XS
NCI-H322M NXzwVHhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfzOG1kUUN3ME25MlE3OjhzIN88US=> MVzTRW5ITVJ?
NCI-H187 NYLyZ|N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nRT2lEPTB;OT61NVg{PSEQvF2= M17lXXNCVkeHUh?=
SBC-1 NIjjb|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[wSIdKSzVyPUmuPVM3PTZizszN MlvyV2FPT0WU
SCC-3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3tTWM2OD1zMD61Olc6KM7:TR?= NGrX[YRUSU6JRWK=
SW948 NIPCbphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon2TWM2OD1zMD63OVEyKM7:TR?= NFvhXppUSU6JRWK=
CPC-N MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:4UmlEPTB;MUGuNFA4KM7:TR?= Mmr5V2FPT0WU
TGBC24TKB NGLUWoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfzTWM2OD1zMz61Nlkh|ryP MYHTRW5ITVJ?
NCI-H2452 NYfV[|k{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvDTWM2OD1zND63N{DPxE1? NEDE[WVUSU6JRWK=
Hs-578-T M2LUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInDUHVKSzVyPUG4MlU4PTlizszN MmrXV2FPT0WU
DV-90 M3Ts[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTF6Lkm5OFUh|ryP NHvKPZdUSU6JRWK=
NCI-H1563 NHr2RZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTF7Lke4PFgh|ryP MWPTRW5ITVJ?
SW780 M2DXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJzLkGzNVgh|ryP NX;CTXdKW0GQR1XS
NCI-H345 NXrWNppTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvJVFhSUUN3ME2yNU45Pzd7IN88US=> M1:wTHNCVkeHUh?=
LB771-HNC Ml3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ{LkS4NVMh|ryP NF3ySpRUSU6JRWK=
RT4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL6TWM2OD1{Mz6zNlgzKM7:TR?= NXn4bVdIW0GQR1XS
NCI-H82 NIfxbYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jabWlEPTB;MkOuOVUzPiEQvF2= MkTuV2FPT0WU
NCI-H524 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD0TWM2OD1{ND6zPFEzKM7:TR?= NEDCVIFUSU6JRWK=
SNU-C1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCxTWM2OD1{ND65NVA2KM7:TR?= Mn31V2FPT0WU
NCI-SNU-16 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHSbWFKSzVyPUS4MlMyPDJizszN M1nWe3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

細胞アッセイ: [1]

細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

動物実験: [3]

動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
製剤 In DMSO and diluted in sterile saline/Tween 20
投薬量 50 mg/kg
投与方法 Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Luminespib (AUY-922, NVP-AUY922) SDF
分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管 3年-20℃
2年-80℃in solvent
別名 VER-52296
溶解度 (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

文献中の引用 (23)

技術サポート&よくある質問(FAQ)

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* 必須

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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