Luminespib (AUY-922, NVP-AUY922) 化学構造
分子量: 465.54

高品質保証

カスタマーフィードバック(3)

MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野
  • Luminespib (AUY-922, NVP-AUY922)のメカニズム

製品の説明

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。
ターゲット HSP90α HSP90β
IC50 13 nM 21 nM [1]
In vitro試験 NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMK MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMECwNVI2KM7:TR?= M3;6cXNCVkeHUh?=
MV-4-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[0RmlEPTB;MD6wNFA2PThizszN M{LjVXNCVkeHUh?=
NALM-6 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDie2lKSzVyPUCuNFAxQDR{IN88US=> MW\TRW5ITVJ?
HOS MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDOXlhKSzVyPUCuNFAyOzhizszN MnnTV2FPT0WU
HT-144 NV3sUmFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXKwV3lOUUN3ME2wMlAxOTV3IN88US=> M3nCenNCVkeHUh?=
SW1710 NVvGUW1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfhTWM2OD1yLkCwNVg3KM7:TR?= NYruTYJwW0GQR1XS
TE-8 M3vWR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWSwU5B{UUN3ME2wMlAxOjN5IN88US=> MknmV2FPT0WU
ES1 NX\TbWpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojFTWM2OD1yLkCwNlY3KM7:TR?= NVu5XYN7W0GQR1XS
CCF-STTG1 NELjUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfvTWM2OD1yLkCwNlk4KM7:TR?= Mn;sV2FPT0WU
PSN1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDxZ45KSzVyPUCuNFA{OThizszN M1zXenNCVkeHUh?=
CAL-51 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nZOGlEPTB;MD6wNFMzPSEQvF2= NUex[mpEW0GQR1XS
MCF7 NVvPPXBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMECzN|Uh|ryP MYrTRW5ITVJ?
SK-HEP-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn61TWM2OD1yLkCwN|M3KM7:TR?= NFy0[pdUSU6JRWK=
LCLC-103H M2XmbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LafWlEPTB;MD6wNFQ{KM7:TR?= MWXTRW5ITVJ?
HMV-II NYTJPGd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTPTWM2OD1yLkCwOFQ6KM7:TR?= NIDweotUSU6JRWK=
MES-SA NUDrV3ZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFKwXnpKSzVyPUCuNFA1PTJizszN NFywcW9USU6JRWK=
SK-LMS-1 NEjrWnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEC0OVgh|ryP M3\MVnNCVkeHUh?=
639-V NVTFNmIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMEC0PFUh|ryP M{XVSXNCVkeHUh?=
SIG-M5 NIXQVFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEC0PFkh|ryP MnTZV2FPT0WU
LOUCY NFPM[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfS[m5xUUN3ME2wMlAxPTB3IN88US=> MX3TRW5ITVJ?
HSC-2 NFjJWJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEC1NVgh|ryP M132O3NCVkeHUh?=
EW-13 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nRVGlEPTB;MD6wNFUyQCEQvF2= NFjvdG1USU6JRWK=
RT-112 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEC1N|Uh|ryP NVfXV|VRW0GQR1XS
NKM-1 NGDDUo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj3VpNkUUN3ME2wMlAxPTR5IN88US=> MV3TRW5ITVJ?
KYSE-180 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HuN2lEPTB;MD6wNFU5PiEQvF2= MUPTRW5ITVJ?
SW1783 NInTbVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[3XpFMUUN3ME2wMlAxPTlzIN88US=> NV;YdGJ[W0GQR1XS
A431 NXn4SpE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEC2NFch|ryP M{e2[3NCVkeHUh?=
SK-OV-3 NGnocFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEC2N{DPxE1? M3HkcXNCVkeHUh?=
RPMI-7951 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnhT5hMUUN3ME2wMlAxPjNzIN88US=> M1\QTnNCVkeHUh?=
Capan-2 NHvudFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCzOJlUUUN3ME2wMlAxPjN6IN88US=> MkLlV2FPT0WU
HSC-3 Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j5WWlEPTB;MD6wNFY1OSEQvF2= MWPTRW5ITVJ?
786-0 NUXzcYdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEC2OlMh|ryP MUDTRW5ITVJ?
Daoy MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLaXXpKSzVyPUCuNFA3QTVizszN M{P2V3NCVkeHUh?=
KGN MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDOWXdSUUN3ME2wMlAxPzB|IN88US=> M{HJPXNCVkeHUh?=
EW-16 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrwVFVKSzVyPUCuNFA4PDlizszN MnPPV2FPT0WU
EW-7 NX:3WmVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Xnd2lEPTB;MD6wNFc2PCEQvF2= M3[2V3NCVkeHUh?=
IGROV-1 NXjoRYppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[zOWlEPTB;MD6wNFgyPCEQvF2= M1G4e3NCVkeHUh?=
8505C MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUSydmZ3UUN3ME2wMlAxQDJzIN88US=> MYPTRW5ITVJ?
RKO NEDTT5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEC4NlYh|ryP Ml;mV2FPT0WU
GDM-1 M{HIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7z[ndKSzVyPUCuNFA5PCEQvF2= NH\IZWFUSU6JRWK=
IST-MEL1 NYXCfYxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjzNHNKSzVyPUCuNFA5PTJizszN M{HBNHNCVkeHUh?=
RPMI-6666 M3qyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;uWnRKSzVyPUCuNFA5PTJizszN MWTTRW5ITVJ?
SNG-M M2L6XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\YXmlKSzVyPUCuNFA5PTZizszN NEPDNI9USU6JRWK=
KS-1 NXnjdoJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3sOZJKSzVyPUCuNFA5PTlizszN MWXTRW5ITVJ?
RXF393 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fvVGlEPTB;MD6wNFg3KM7:TR?= M4TpW3NCVkeHUh?=
CAL-12T M2K3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j4TWlEPTB;MD6wNFkzOiEQvF2= M364d3NCVkeHUh?=
BFTC-905 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLrVHhpUUN3ME2wMlAxQTN6IN88US=> NXzHVmNpW0GQR1XS
SK-MES-1 NGm4SoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEC5OFUh|ryP MmDvV2FPT0WU
BB30-HNC NXLLVGZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi4TWM2OD1yLkCwPVUzKM7:TR?= MWDTRW5ITVJ?
AN3-CA M4DxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTuTWM2OD1yLkCxNFE4KM7:TR?= MnPmV2FPT0WU
EFO-27 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDlTWM2OD1yLkCxNFE4KM7:TR?= NEnOcpFUSU6JRWK=
G-401 M2\sbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7tTWM2OD1yLkCxNFI2KM7:TR?= NHX0NYdUSU6JRWK=
BPH-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn2TWM2OD1yLkCxNFMh|ryP M{CzUnNCVkeHUh?=
NCI-H727 NVyzWWJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIexPJVKSzVyPUCuNFExOyEQvF2= M37RWHNCVkeHUh?=
SNU-423 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMEGwOVMh|ryP MY\TRW5ITVJ?
KYSE-270 M4X4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TWR2lEPTB;MD6wNVA2QSEQvF2= NHvTdoRUSU6JRWK=
AGS M2HjV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHX3fplKSzVyPUCuNFExPjFizszN MoWzV2FPT0WU
NCI-H2228 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEGwOlQh|ryP NFLVWYhUSU6JRWK=
SW954 NW\VTG45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PaZWlEPTB;MD6wNVA4OSEQvF2= MVnTRW5ITVJ?
769-P M3P2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:zSmpEUUN3ME2wMlAyODd|IN88US=> M{fPPXNCVkeHUh?=
BB49-HNC Mn3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEGwO|ch|ryP NHvLVZdUSU6JRWK=
IA-LM M{TofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe4b5B7UUN3ME2wMlAyODh4IN88US=> NETmfVlUSU6JRWK=
NB69 M1f5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7MTWM2OD1yLkCxNVAzKM7:TR?= NGDlbpVUSU6JRWK=
C8166 M4LEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH3TWM2OD1yLkCxNVI6KM7:TR?= NWjwV5NQW0GQR1XS
NCI-H1299 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEGxOVQh|ryP M2\ydXNCVkeHUh?=
YKG-1 NHe2ZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jmSWlEPTB;MD6wNVE3KM7:TR?= MXrTRW5ITVJ?
PANC-03-27 M{fUVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjkTWM2OD1yLkCxNVYzKM7:TR?= MVLTRW5ITVJ?
YT NEXVdlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnBS|MxUUN3ME2wMlAyOTd7IN88US=> NILTTodUSU6JRWK=
CAL-85-1 NVL6Z5oxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:4epdKUUN3ME2wMlAyOTl{IN88US=> MonoV2FPT0WU
GT3TKB M17lRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfOO4lKSzVyPUCuNFEzODJizszN NInh[5JUSU6JRWK=
BB65-RCC NH[4dlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17WfmlEPTB;MD6wNVIxPCEQvF2= M1zKdnNCVkeHUh?=
ES6 M2nacmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr1TWM2OD1yLkCxNlYyKM7:TR?= MoOwV2FPT0WU
MHH-ES-1 M1XBU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PpVGlEPTB;MD6wNVI3OyEQvF2= M2noUnNCVkeHUh?=
QIMR-WIL MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMEGyOlkh|ryP M2[z[HNCVkeHUh?=
SNU-C2B M{nLRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTGV45KSzVyPUCuNFEzPzJizszN NYjMUlVtW0GQR1XS
OCI-AML2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PI[WlEPTB;MD6wNVI5OSEQvF2= NF;4eIlUSU6JRWK=
DU-145 NVP0d4s1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTreXRtUUN3ME2wMlAyOjlizszN NEXwWZNUSU6JRWK=
SW982 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjsTWM2OD1yLkCxNlk{KM7:TR?= MlTKV2FPT0WU
MFH-ino NXzPPY1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PydWlEPTB;MD6wNVI6OyEQvF2= M4qwVnNCVkeHUh?=
A427 NITHcJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zHfWlEPTB;MD6wNVI6QSEQvF2= NHLKXIxUSU6JRWK=
LCLC-97TM1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTDbFhmUUN3ME2wMlAyOyEQvF2= M3z2[XNCVkeHUh?=
AM-38 M3S5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnLUFQ{UUN3ME2wMlAyOzB{IN88US=> M320R3NCVkeHUh?=
K5 M{XGcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn2boRmUUN3ME2wMlAyOzB6IN88US=> NVy0PIxuW0GQR1XS
T84 NVjmb3B2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHGPIhKSzVyPUCuNFE{OzFizszN NUP5T|VEW0GQR1XS
TE-15 MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEGzN|Yh|ryP M1PnPHNCVkeHUh?=
NCI-H460 NVrn[G01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEGzN|Yh|ryP MXzTRW5ITVJ?
NTERA-S-cl-D1 Mn;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD4[Wg{UUN3ME2wMlAyOzN7IN88US=> M1LvO3NCVkeHUh?=
KYSE-450 NYPYdY5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\T[4pKSzVyPUCuNFE{PDlizszN M3rhS3NCVkeHUh?=
H4 NV:2NHBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\UTWM2OD1yLkCxN|Y3KM7:TR?= MYLTRW5ITVJ?
LC-2-ad MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHBOmNzUUN3ME2wMlAyOzdizszN MVPTRW5ITVJ?
GAMG M2LJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nkemlEPTB;MD6wNVM4OSEQvF2= NXjjdHJvW0GQR1XS
TK10 M4n0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEGzPFIh|ryP NEXIZpZUSU6JRWK=
NCI-H2122 M4rtW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrwO3dTUUN3ME2wMlAyOzh2IN88US=> NYfnOJZ6W0GQR1XS
KM12 M17Wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnV[ZdKSzVyPUCuNFE{QTlizszN NIf5PGNUSU6JRWK=
CAL-39 M4LvTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\oWll3UUN3ME2wMlAyPDJizszN M1X1dXNCVkeHUh?=
RPMI-2650 M{HPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ryXWlEPTB;MD6wNVQ{OiEQvF2= NVy1Z5I4W0GQR1XS
KYSE-510 NUH0SpJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnmTYdKSzVyPUCuNFE1PDJizszN MmnUV2FPT0WU
KALS-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEG0OlYh|ryP MmX0V2FPT0WU
NCI-H1648 Mn\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEG0PVkh|ryP M1;GNHNCVkeHUh?=
ES4 NW\QdnAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHne4hmUUN3ME2wMlAyPTB{IN88US=> MkfhV2FPT0WU
C-33-A NEH1NYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULE[WpkUUN3ME2wMlAyPTB7IN88US=> MY\TRW5ITVJ?
MIA-PaCa-2 NUDpT41yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUmwSJk6UUN3ME2wMlAyPTB7IN88US=> NV3a[|M6W0GQR1XS
Becker MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P2R2lEPTB;MD6wNVUyPCEQvF2= NXnU[WVCW0GQR1XS
HOP-62 NGrxRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESxfpZKSzVyPUCuNFE2PDJizszN M3exWXNCVkeHUh?=
TE-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLLUZZkUUN3ME2wMlAyPThzIN88US=> M{LrUHNCVkeHUh?=
KYSE-410 NF3kZ3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfjd|FSUUN3ME2wMlAyPTh4IN88US=> NHjy[3VUSU6JRWK=
NOS-1 MlfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\CTWM2OD1yLkCxOVk{KM7:TR?= NHnq[VJUSU6JRWK=
MEL-HO MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELZN5VKSzVyPUCuNFE3PDNizszN MoCxV2FPT0WU
NCI-H1650 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEG2OFYh|ryP NEfXVZRUSU6JRWK=
VMRC-RCZ NVXj[YtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:z[ZJvUUN3ME2wMlAyPjVzIN88US=> MojVV2FPT0WU
HuP-T3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfqWJBKSzVyPUCuNFE3PTNizszN MknTV2FPT0WU
ACN MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDHTWM2OD1yLkCxOlU4KM7:TR?= MVjTRW5ITVJ?
MEL-JUSO NVfxUHhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHVT5ZKSzVyPUCuNFE3QDFizszN M17jUnNCVkeHUh?=
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22RV1 M1zEdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M376WGlEPTB;MD6wN|UxPyEQvF2= MWfTRW5ITVJ?
ES8 NGPRTpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjLTWM2OD1yLkCzOVM5KM7:TR?= MVjTRW5ITVJ?
KYSE-150 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUiwcJJxUUN3ME2wMlA{PjB6IN88US=> Ml[zV2FPT0WU
HCC1569 M1XqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXhbXNuUUN3ME2wMlA{PjB6IN88US=> MmHBV2FPT0WU
NB5 NV;IcXR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEO2NVMh|ryP M3S4TnNCVkeHUh?=
G-402 NEXoWGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEO2NVQh|ryP MnHrV2FPT0WU
NCI-H1693 M4m5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEO2NVch|ryP MVfTRW5ITVJ?
LB2241-RCC NUXhS4ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEO2OFIh|ryP M3GxUXNCVkeHUh?=
KP-4 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\mOWJKSzVyPUCuNFM3PjNizszN NEHybWlUSU6JRWK=
ML-2 MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC0TWM2OD1yLkCzOlcyKM7:TR?= MY\TRW5ITVJ?
KU812 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjpUIJKSzVyPUCuNFM3QDRizszN MonPV2FPT0WU
LS-411N M3S3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7Vc3lKSzVyPUCuNFM4OzFizszN NX;Zb4dCW0GQR1XS
OAW-42 NY\WS3ZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnDb3dKSzVyPUCuNFM4PDdizszN MmDjV2FPT0WU
HCC38 NIjSTVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPITWM2OD1yLkCzO|cyKM7:TR?= MYHTRW5ITVJ?
Ca-Ski M{TKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3CWGhKSzVyPUCuNFM4QDRizszN MVPTRW5ITVJ?
Calu-3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEO3PFkh|ryP NYXJNmtiW0GQR1XS
KYSE-70 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEO4NVIh|ryP MnjLV2FPT0WU
D-392MG NUjENVlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;3TWM2OD1yLkCzPFQzKM7:TR?= M1zPXHNCVkeHUh?=
OVCAR-4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPmSFVKSzVyPUCuNFM5PThizszN M4\k[nNCVkeHUh?=
Detroit562 NG\ETWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHITWM2OD1yLkCzPFczKM7:TR?= NYXUbXl6W0GQR1XS
HEL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrhUZZKSzVyPUCuNFM5QTFizszN MmTDV2FPT0WU
MONO-MAC-6 M3i5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37mOmlEPTB;MD6wN|g6OyEQvF2= NGDybmxUSU6JRWK=
LoVo M1\GXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEO5N|Mh|ryP NEHoVXJUSU6JRWK=
U-2-OS M3\Ze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTDb2xKSzVyPUCuNFM6OzVizszN NF7V[ZRUSU6JRWK=
A172 M1;PZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnVNplsUUN3ME2wMlA{QTVizszN NFzLfFJUSU6JRWK=
OCUB-M M2P2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzONoRKSzVyPUCuNFM6PjFizszN M4fOS3NCVkeHUh?=
SW48 NHj6V4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\qWYpKSzVyPUCuNFQxOzFizszN MV3TRW5ITVJ?
HC-1 MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HOS2lEPTB;MD6wOFA3QSEQvF2= NECxbnNUSU6JRWK=
KOSC-2 Mm\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX4eGZZUUN3ME2wMlA1OTFizszN MlTRV2FPT0WU
HDLM-2 M17O[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLITWM2OD1yLkC0NVE1KM7:TR?= M1nScXNCVkeHUh?=
CTV-1 NHf4XFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jyTmlEPTB;MD6wOFEyPiEQvF2= NX\sOllbW0GQR1XS
SH-4 NVXEPJlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMESxOFEh|ryP MWrTRW5ITVJ?
SW756 NF7XNnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMESxOVch|ryP M1fyfHNCVkeHUh?=
GCT M2\kNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXzNXRKSzVyPUCuNFQyPjFizszN NXfGZ2hmW0GQR1XS
CHL-1 M4PWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXTTWM2OD1yLkC0NVY6KM7:TR?= M1rZeXNCVkeHUh?=
LAMA-84 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7VcpRKSzVyPUCuNFQyPzFizszN MVrTRW5ITVJ?
LS-1034 NH\Ge4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnmO4ZKSzVyPUCuNFQyQTFizszN M36zTHNCVkeHUh?=
NCI-H358 NVfoPZdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMESyNVIh|ryP MoHmV2FPT0WU
NB13 M2W1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe1TWM2OD1yLkC0NlI4KM7:TR?= NX;0emF7W0GQR1XS
TE-9 NH;PW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDvTWM2OD1yLkC0NlM4KM7:TR?= NWLTSXpiW0GQR1XS
OE33 Ml6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMESyOFEh|ryP MYnTRW5ITVJ?
CAL-120 MkPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMESyOFEh|ryP NIP5TmxUSU6JRWK=
DJM-1 Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DSdWlEPTB;MD6wOFI4OiEQvF2= M2TMc3NCVkeHUh?=
SK-MEL-24 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f0O2lEPTB;MD6wOFI5OyEQvF2= MXvTRW5ITVJ?
VA-ES-BJ MlO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMESyPVIh|ryP MVXTRW5ITVJ?
MMAC-SF NXzUenVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PpR2lEPTB;MD6wOFI6PyEQvF2= MXPTRW5ITVJ?
MZ7-mel NID1XWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TCO2lEPTB;MD6wOFM{KM7:TR?= Ml7MV2FPT0WU
BxPC-3 NFHsT3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMESzOFEh|ryP NEPXOmtUSU6JRWK=
HT-29 M3TVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[1b3ZKSzVyPUCuNFQ{PTdizszN NYLwSJRpW0GQR1XS
SK-MEL-30 NHqwU5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\oc4dsUUN3ME2wMlA1OzZ{IN88US=> NVjkfJhjW0GQR1XS
CAL-33 NVG0RZZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv4NVBKSzVyPUCuNFQ{PzVizszN MkXCV2FPT0WU
COLO-680N NGH2NINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj4W|BKSzVyPUCuNFQ1ODdizszN MnTXV2FPT0WU
NH-12 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr4UWxKSzVyPUCuNFQ1PCEQvF2= NHmzWFRUSU6JRWK=
HCC1937 MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkO3TWM2OD1yLkC0OFU3KM7:TR?= MkCyV2FPT0WU
IMR-5 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMES0PUDPxE1? M2S3cXNCVkeHUh?=
MC-CAR M4LXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;nfYVtUUN3ME2wMlA1PTZ7IN88US=> NYP5eZhtW0GQR1XS
NCI-H747 MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13xVmlEPTB;MD6wOFU4KM7:TR?= NWnz[GRbW0GQR1XS
NCI-H1792 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuxeXlKSzVyPUCuNFQ2QDFizszN NFvQRYxUSU6JRWK=
SW13 Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXIXlFKSzVyPUCuNFQ2QSEQvF2= NEL3WFJUSU6JRWK=
MLMA NYfJd4pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn5[|VXUUN3ME2wMlA1PjB7IN88US=> NXHZSJRYW0GQR1XS
U251 NFWy[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLMTWM2OD1yLkC0O|Y{KM7:TR?= M2\1OHNCVkeHUh?=
U031 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYT1V3lQUUN3ME2wMlA1PzdzIN88US=> MnzlV2FPT0WU
ME-180 M3XyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjybYdKSzVyPUCuNFQ4QDJizszN NXS3Z4pkW0GQR1XS
SK-MEL-3 MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMES4NFIh|ryP Mo\BV2FPT0WU
MOLT-4 M4rNO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;HOVQ6UUN3ME2wMlA1QDB|IN88US=> MXrTRW5ITVJ?
PF-382 NX:2b2l{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkniTWM2OD1yLkC0PFI3KM7:TR?= MWnTRW5ITVJ?
NUGC-3 M2\ONmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMES4Nlch|ryP M3TlW3NCVkeHUh?=
NCI-H1417 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XCd2lEPTB;MD6wOFg6KM7:TR?= MX3TRW5ITVJ?
COLO-205 NIe2U2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTFTWM2OD1yLkC0PVE6KM7:TR?= NHjjZWZUSU6JRWK=
TE-441-T M2POT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTGTWM2OD1yLkC0PVMh|ryP MUjTRW5ITVJ?
MKN1 NUjxNlc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXpbW9KSzVyPUCuNFQ6OyEQvF2= MUTTRW5ITVJ?
UM-UC-3 M2LaTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2W1e2lEPTB;MD6wOFk2KM7:TR?= NXv2OFNtW0GQR1XS
SF126 NITXWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXroZ|B5UUN3ME2wMlA2ODFizszN M3HoSnNCVkeHUh?=
LB1047-RCC NVy3SWN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfsRY5KSzVyPUCuNFUxOzFizszN MoSyV2FPT0WU
A253 M1zBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPOO2FyUUN3ME2wMlA2ODV{IN88US=> NV3KWZpvW0GQR1XS
NCI-H1963 MoD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Lu[2lEPTB;MD6wOVE4PiEQvF2= MlroV2FPT0WU
VM-CUB-1 M1mwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjSTWM2OD1yLkC1N|EyKM7:TR?= M1\vSHNCVkeHUh?=
T-24 Mn;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j0O2lEPTB;MD6wOVM5PCEQvF2= M3jRPHNCVkeHUh?=
K-562 NHr0TlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmySo4zUUN3ME2wMlA2Ozh5IN88US=> NGrwdWNUSU6JRWK=
ARH-77 M3HiZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\qOVBKSzVyPUCuNFU{QTVizszN M2PsVHNCVkeHUh?=
CA46 M2DkeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn5d|ZKSzVyPUCuNFU1OyEQvF2= NHPSOWhUSU6JRWK=
HCC70 NUjBeJloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nxRmlEPTB;MD6wOVQ2OiEQvF2= M{\pRXNCVkeHUh?=
ST486 MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vx[WlEPTB;MD6wOVUzPSEQvF2= NWnxe2t7W0GQR1XS
COLO-741 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEW1N|Eh|ryP NYLKRZFsW0GQR1XS
SK-PN-DW M2jER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe1PJVKSzVyPUCuNFU2QDhizszN Mmf6V2FPT0WU
BL-41 M{nvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3YZph3UUN3ME2wMlA2PTl4IN88US=> NEDjTmZUSU6JRWK=
D-263MG MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;QSGpKUUN3ME2wMlA2Pjh|IN88US=> NYXKXG5mW0GQR1XS
KE-37 M3HYTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1flXmlEPTB;MD6wOVY5OyEQvF2= NGrOOGhUSU6JRWK=
LU-134-A Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMEW3NVUh|ryP NX7pdFJiW0GQR1XS
HCC2157 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33tVmlEPTB;MD6wOVc{OyEQvF2= MmqxV2FPT0WU
GAK NEiwbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX2[3NKSzVyPUCuNFU4OzRizszN NYXrVoFyW0GQR1XS
IST-SL2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEW3OFMh|ryP NGq4ZVdUSU6JRWK=
KMOE-2 Ml;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEW3OFkh|ryP MXTTRW5ITVJ?
SW1573 NXmxfJRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XkdmlEPTB;MD6wOVgxOiEQvF2= MWDTRW5ITVJ?
SCC-9 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1q0VWlEPTB;MD6wOVg4KM7:TR?= NGTL[|dUSU6JRWK=
MDA-MB-361 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjaTWM2OD1yLkC1PFczKM7:TR?= NFf2TXRUSU6JRWK=
BHT-101 NVrsOm9mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PrbGlEPTB;MD6wOVg4PiEQvF2= Mn;zV2FPT0WU
NCI-H1770 NH3NSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPGOFhKSzVyPUCuNFU5PzlizszN Moq2V2FPT0WU
UACC-893 M4jvfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEW4PVYh|ryP MoPqV2FPT0WU
NCI-H226 NInuOHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnvO3o{UUN3ME2wMlA2QTh6IN88US=> MVTTRW5ITVJ?
HLE MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGruVHBKSzVyPUCuNFYxQDJizszN NUTERmRvW0GQR1XS
NCI-H1703 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUCxTmlHUUN3ME2wMlA3OTd6IN88US=> MWHTRW5ITVJ?
KURAMOCHI M1vYWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknkTWM2OD1yLkC2NVg6KM7:TR?= NYfMS5BOW0GQR1XS
RH-1 NFLtR29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e4[mlEPTB;MD6wOlI{KM7:TR?= MX\TRW5ITVJ?
DSH1 NFHxNXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LOemlEPTB;MD6wOlI4KM7:TR?= Mnj0V2FPT0WU
CAMA-1 NV3OcIp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlP6TWM2OD1yLkC2N|A{KM7:TR?= NV\PfWh4W0GQR1XS
NCI-H1437 M4fGNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ixdmlEPTB;MD6wOlMzQCEQvF2= Mnv3V2FPT0WU
HuP-T4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITBfGJKSzVyPUCuNFY2QDZizszN NYL0cm1FW0GQR1XS
HCT-15 M2Pqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnf3TWM2OD1yLkC2OVk4KM7:TR?= M3X3bHNCVkeHUh?=
NCCIT NHHuXo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwME[2NFQh|ryP M1XhfXNCVkeHUh?=
BOKU NFOyOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e1TmlEPTB;MD6wOlY4PCEQvF2= MofrV2FPT0WU
FADU MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLaeotKSzVyPUCuNFY4PDVizszN M1X1OHNCVkeHUh?=
SUP-T1 M3m3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37pZmlEPTB;MD6wOlc3KM7:TR?= MVzTRW5ITVJ?
L-363 M4XBXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTmZ4VKSzVyPUCuNFY6ODFizszN MUfTRW5ITVJ?
KNS-81-FD MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr4foU3UUN3ME2wMlA3QTF6IN88US=> NUXpS2xHW0GQR1XS
SU-DHL-1 NXuwSldRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPac2VkUUN3ME2wMlA3QTJizszN NUKzXVlwW0GQR1XS
HuH-7 MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHQdIMyUUN3ME2wMlA4ODN3IN88US=> MU\TRW5ITVJ?
BT-474 NV\H[FNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7YTWM2OD1yLkC3NFYyKM7:TR?= NUfGc4tMW0GQR1XS
CAPAN-1 M3PldGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTRPYl7UUN3ME2wMlA4OTR|IN88US=> NXP0dWI{W0GQR1XS
HEC-1 NVjwSnFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIniXWxKSzVyPUCuNFcyPjFizszN Mlv4V2FPT0WU
NOMO-1 NEfOW2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMEexO|Ih|ryP NUTr[I0{W0GQR1XS
KM-H2 NHrXbJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnY[YlPUUN3ME2wMlA4OjRzIN88US=> M1jJVnNCVkeHUh?=
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TE-6 NUKwW2xRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfucpB5UUN3ME2wMlI1PjF{IN88US=> NG[3bIRUSU6JRWK=
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RL M3z1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknSTWM2OD1yLkK4NVc1KM7:TR?= M2r0SHNCVkeHUh?=
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EW-24 NGjZdlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMki4NUDPxE1? NV:4e2F1W0GQR1XS
NCI-H510A MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ruSGlEPTB;MD6yPVMxPCEQvF2= MWLTRW5ITVJ?
Mo-T NVqxRWd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXGwWpE1UUN3ME2wMlI6OzNzIN88US=> NEjpd3NUSU6JRWK=
LB373-MEL-D M{\tcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXyTWM2OD1yLkK5OFMyKM7:TR?= NFTmZnNUSU6JRWK=
NCI-H28 NIHBd5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\EPGlEPTB;MD6yPVg{PyEQvF2= MnjBV2FPT0WU
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L-540 M3LjdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jaV2lEPTB;MD6zNFA5QSEQvF2= M32yVHNCVkeHUh?=
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OPM-2 NHf4XZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwM{GwOlQh|ryP MkfyV2FPT0WU
BT-20 M4THVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwM{GwPVkh|ryP Mmj4V2FPT0WU
KP-N-YN M4T4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHO[nNxUUN3ME2wMlMyOTF6IN88US=> MXfTRW5ITVJ?
MDA-MB-175-VII NHfNbItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\pTWM2OD1yLkOyN|Q5KM7:TR?= NGX4RpNUSU6JRWK=
EFM-19 M{HGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLDd5p6UUN3ME2wMlM{OTN{IN88US=> NHfOV4JUSU6JRWK=
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NCI-H719 M1XROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PIc2lEPTB;MD6zOVEzPCEQvF2= M3XiW3NCVkeHUh?=
MFE-280 M1W1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwM{W3NVUh|ryP NFLVepVUSU6JRWK=
DMS-114 NFT0TWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{juVGlEPTB;MD6zOlEzKM7:TR?= NEHHN2NUSU6JRWK=
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SK-N-FI M{D6Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jTV2lEPTB;MD6zO|Y{PyEQvF2= NWP3[ZBPW0GQR1XS
LB2518-MEL NH;XS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjrXnNKSzVyPUCuOFA5PzJizszN Mn7qV2FPT0WU
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NCI-H1882 M1HOTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjp[mJyUUN3ME2wMlQyPzh2IN88US=> M1;lcXNCVkeHUh?=
JVM-2 NF[yN4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzn[ZA4UUN3ME2wMlQ1PDBzIN88US=> MnWwV2FPT0WU
T47D Ml33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2SzZmlEPTB;MD60OFUzQCEQvF2= MXjTRW5ITVJ?
MHH-CALL-2 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\RTWM2OD1yLkS0PFMh|ryP MnrRV2FPT0WU
NCI-H716 NV;hW3dVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFG4WohKSzVyPUCuOFQ5PDhizszN M3ztSnNCVkeHUh?=
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UACC-812 M3PXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjyTWM2OD1yLkS2O|c3KM7:TR?= M1uwfXNCVkeHUh?=
D-502MG M17DSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rPcGlEPTB;MD60PFA{KM7:TR?= M1nwUnNCVkeHUh?=
CaR-1 NHT1S|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X5Z2lEPTB;MD61NFM3PyEQvF2= MnSyV2FPT0WU
LU-139 MmnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HLTWlEPTB;MD61NVQ2PyEQvF2= M3nvSXNCVkeHUh?=
RPMI-8402 MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjZTWM2OD1yLkWyNlA4KM7:TR?= MYLTRW5ITVJ?
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JVM-3 NXXhd|hGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwNUSxNVch|ryP MYTTRW5ITVJ?
YAPC Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwNUWyNVEh|ryP NWHLbY9iW0GQR1XS
KG-1 NYnBVJpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LINWlEPTB;MD61OVk5PCEQvF2= M37COnNCVkeHUh?=
C32 M3XIUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LVVWlEPTB;MD61O|MyOyEQvF2= M{jkeHNCVkeHUh?=
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NCI-H2126 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwNkOxOVIh|ryP NGHMUGJUSU6JRWK=
HCC1954 NFni[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwNkS3NlYh|ryP M4TicXNCVkeHUh?=
WM-115 M3LBOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwNkWwPVIh|ryP NYjxbYsxW0GQR1XS
NB6 NVXz[lQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrWeGx4UUN3ME2wMlY4OzN3IN88US=> MX7TRW5ITVJ?
TYK-nu NYHTV29bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;xUGlKSzVyPUCuOlc6PTJizszN MXHTRW5ITVJ?
KY821 M2XLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf2TWM2OD1yLkewNlI6KM7:TR?= NUTUcYNuW0GQR1XS
SIMA NVHR[oc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPXTWM2OD1yLkexO|E6KM7:TR?= MoDEV2FPT0WU
RCC10RGB NETN[YZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\pdGlEPTB;MD63NVkyQCEQvF2= M{TZcnNCVkeHUh?=
LN-405 NI\tOHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwN{SzOkDPxE1? MVPTRW5ITVJ?
NCI-H1155 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHX4dohKSzVyPUCuO|Q5PjhizszN NWX5O5d[W0GQR1XS
SCLC-21H MkfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwN{[5NFMh|ryP NWLWN5YyW0GQR1XS
DMS-79 M4LPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fFe2lEPTB;MD63O|g1PSEQvF2= MorlV2FPT0WU
EC-GI-10 NGe1[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTVOYNKSzVyPUCuO|c6PzVizszN MoqwV2FPT0WU
KNS-42 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[0TWM2OD1yLke4PFMyKM7:TR?= M124PHNCVkeHUh?=
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SF539 M{e1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofVTWM2OD1yLke5PVI2KM7:TR?= M3zpUHNCVkeHUh?=
SW1417 MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3OcJlKSzVyPUCuPFE{OzlizszN NUi4PWtUW0GQR1XS
ATN-1 M4Xjbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTBPWFTUUN3ME2wMlg2OTF3IN88US=> MljWV2FPT0WU
PLC-PRF-5 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrmW2JKSzVyPUCuPFg1PzVizszN M2DjVHNCVkeHUh?=
HT-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnxd3hbUUN3ME2wMlg6PDJizszN NHm5T4NUSU6JRWK=
MDA-MB-453 NHTRW5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwOUCzNFQh|ryP M4Dm[3NCVkeHUh?=
HAL-01 NV\6Z4xWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO0WIUxUUN3ME2wMlk6Ozd7IN88US=> MX;TRW5ITVJ?
NCI-H1993 NYraeG1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFwMES2OVch|ryP NFHKUFhUSU6JRWK=
NCI-H2227 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTFwMES5PFEh|ryP NUK5fGpLW0GQR1XS
LP-1 MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwME[5N{DPxE1? M4DSbnNCVkeHUh?=
P31-FUJ NECzWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjBWJV4UUN3ME2xMlExPzZ4IN88US=> M1vIfHNCVkeHUh?=
NCI-H64 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLkTWM2OD1zLkG1OFIh|ryP M3P3VXNCVkeHUh?=
SW1463 M4rzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHntUGRKSzVyPUGuNVg{PDlizszN M3fTUXNCVkeHUh?=
SK-MEL-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\rTWM2OD1zLkKwOVk2KM7:TR?= MkWzV2FPT0WU
TALL-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fVT2lEPTB;MT6yOVE3PSEQvF2= M37RenNCVkeHUh?=
RO82-W-1 Ml;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVeyTZJ7UUN3ME2xMlM{OzN7IN88US=> NVzzcoVsW0GQR1XS
NCI-H1581 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfOTmxKSzVyPUGuN|U3QDdizszN NH\LblRUSU6JRWK=
NCI-H748 NEO1R2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjRbI9JUUN3ME2xMlM2PzN6IN88US=> NWrt[JhCW0GQR1XS
HCC1187 NHTkToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKyTWM2OD1zLkW1OVIzKM7:TR?= NFGySnNUSU6JRWK=
EoL-1-cell MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjQb5dsUUN3ME2xMlU5QDh7IN88US=> MlnkV2FPT0WU
HuO-3N1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnTTWM2OD1zLkizOFEzKM7:TR?= M4mwPHNCVkeHUh?=
NCI-H1793 NHj3NJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\ONXRxUUN3ME2xMlg4PTl|IN88US=> NUnYTY5MW0GQR1XS
Caov-3 Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG4XW1KSzVyPUKuNFA3OjVizszN NEDF[WNUSU6JRWK=
JAR MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzHTWM2OD1{LkC3PVIh|ryP NGnXPFhUSU6JRWK=
SK-MEL-28 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLue2FKSzVyPUKuNVgxQThizszN M{i0VHNCVkeHUh?=
EM-2 NIDsWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTsdXRpUUN3ME2yMlIxOjl|IN88US=> MXrTRW5ITVJ?
Mewo NXPMOHRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\vTWM2OD1{LkKyNlY2KM7:TR?= NHzUeXhUSU6JRWK=
NCI-H720 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LPVmlEPTB;Mj6yOlU5PSEQvF2= M3\JfHNCVkeHUh?=
CAL-54 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLXZWJKSzVyPUKuNlY4QTVizszN NVjrXI8yW0GQR1XS
MC116 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3T3RWlEPTB;Mj6zOlM6PyEQvF2= NGPpbGdUSU6JRWK=
DG-75 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvHfIUyUUN3ME2yMlQ5PTd4IN88US=> NGTufoZUSU6JRWK=
HCC1143 NFnsVotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjnb2pYUUN3ME2yMlUxPjV6IN88US=> NXvEV5lKW0GQR1XS
FTC-133 MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvpPIVwUUN3ME2yMlU{Pjh7IN88US=> NXq3PWVXW0GQR1XS
AsPC-1 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoixTWM2OD1{LkWzPVI6KM7:TR?= M{XPbXNCVkeHUh?=
NCI-H889 MlG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;NTWM2OD1{LkW2O|A3KM7:TR?= Ml2yV2FPT0WU
HT55 M4j6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny1TWM2OD1{Lk[yNFE6KM7:TR?= NUK1bWRrW0GQR1XS
UMC-11 NVT6dnBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnafJF5UUN3ME2yMlc5PzF3IN88US=> M{nXVHNCVkeHUh?=
P12-ICHIKAWA NXXjW4ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLnUIpKSzVyPUKuPFIxPDZizszN NFPBOVlUSU6JRWK=
HCC1395 NXP5RVRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnMZpY3UUN3ME2yMlk5PjB{IN88US=> NH[5[mFUSU6JRWK=
D-283MED NF7XWnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmmyTWM2OD1|LkG4PVM4KM7:TR?= NFG2XYdUSU6JRWK=
COLO-800 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TLNWlEPTB;Mz6zN|g6PyEQvF2= MkTyV2FPT0WU
MFM-223 NWTLb5dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13l[2lEPTB;Mz6zOlA6PyEQvF2= Mm\4V2FPT0WU
TE-5 NVHW[Wt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qyXGlEPTB;ND61OlE1PyEQvF2= MmXnV2FPT0WU
NCI-H209 MmLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXsflZJUUN3ME20Mlc5PTd{IN88US=> M{L1XnNCVkeHUh?=
SiHa M1HOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HJVGlEPTB;ND65OVIxOyEQvF2= NVT1fnQxW0GQR1XS
NCI-H1395 NInaSopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvY[VZKSzVyPUWuNVA3OzNizszN NUnVfXlxW0GQR1XS
A498 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTVwMkGyOVEh|ryP M2fBe3NCVkeHUh?=
ES5 MoTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX5NXdKSzVyPUWuOlEyPzhizszN MWrTRW5ITVJ?
MDA-MB-157 M2r5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LtS2lEPTB;NT62OlQ1OyEQvF2= M2TRenNCVkeHUh?=
NCI-H1623 NXvST2twT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG2U2Q2UUN3ME21Mlg{PTV4IN88US=> M3TK[HNCVkeHUh?=
RPMI-8866 NXTXXlM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTVwOES3PVIh|ryP M4PY[HNCVkeHUh?=
LC-1F M3O3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorNTWM2OD14LkC5NlkyKM7:TR?= NE\6PI5USU6JRWK=
TCCSUP M3jrXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSySmdKSzVyPU[uOlA{PDlizszN NEjo[mxUSU6JRWK=
TT MnO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvnTWM2OD16LkOzNFA6KM7:TR?= NIDOPZJUSU6JRWK=
NCI-H1838 NH71VIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[3O2JKSzVyPUiuOVE4OzFizszN Ml3iV2FPT0WU
NCI-H322M NILZT3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK2epRKSzVyPUmuNVYzQDFizszN NIfUVFVUSU6JRWK=
NCI-H187 M3;PVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Pt[WlEPTB;OT61NVg{PSEQvF2= MmPGV2FPT0WU
SBC-1 Ml32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3UVWhRUUN3ME25Mlk{PjV4IN88US=> NVrDVVl{W0GQR1XS
SCC-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nQfmlEPTB;MUCuOVY4QSEQvF2= NXq5Uph7W0GQR1XS
SW948 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTFyLke1NVEh|ryP MoPXV2FPT0WU
CPC-N MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTlc3pKSzVyPUGxMlAxPyEQvF2= M2HQTXNCVkeHUh?=
TGBC24TKB M3LB[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jrO2lEPTB;MUOuOVI6KM7:TR?= NWXDS2tWW0GQR1XS
NCI-H2452 NUjQTYNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7OdndKSzVyPUG0Mlc{KM7:TR?= NGD2UpdUSU6JRWK=
Hs-578-T M3znZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDiTWM2OD1zOD61O|U6KM7:TR?= MWHTRW5ITVJ?
DV-90 Mk\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7pdINUUUN3ME2xPE46QTR3IN88US=> NYHuVoVFW0GQR1XS
NCI-H1563 MoT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF7Lke4PFgh|ryP MWjTRW5ITVJ?
SW780 NE\GcVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnW[nhKSzVyPUKxMlE{OThizszN MnfCV2FPT0WU
NCI-H345 NH\PNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe3OGdKSzVyPUKxMlg4PzlizszN NFH1eIRUSU6JRWK=
LB771-HNC M2PkWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnGUVFKSzVyPUKyMlQ5OTNizszN MkHoV2FPT0WU
RT4 NW\CSWdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDCTWM2OD1{Mz6zNlgzKM7:TR?= MXHTRW5ITVJ?
NCI-H82 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofITWM2OD1{Mz61OVI3KM7:TR?= Mn\vV2FPT0WU
NCI-H524 M4Do[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfTcno1UUN3ME2yOE4{QDF{IN88US=> MV;TRW5ITVJ?
SNU-C1 MmDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXDTWM2OD1{ND65NVA2KM7:TR?= MonLV2FPT0WU
NCI-SNU-16 MoLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEW4SnBKSzVyPUS4MlMyPDJizszN NVTWcYtSW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

細胞アッセイ: [1]

細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

動物実験: [3]

動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
製剤 In DMSO and diluted in sterile saline/Tween 20
投薬量 50 mg/kg
投与方法 Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Luminespib (AUY-922, NVP-AUY922) SDF
分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管 3年-20℃
2年-80℃in solvent
別名 VER-52296
溶解度 (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

文献中の引用 (23)

技術サポート&よくある質問(FAQ)

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* 必須

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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