Luminespib (AUY-922, NVP-AUY922) 化学構造
分子量: 465.54

高品質保証

カスタマーフィードバック(3)

MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野
  • Luminespib (AUY-922, NVP-AUY922)のメカニズム

製品の説明

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。
ターゲット HSP90α HSP90β
IC50 13 nM 21 nM [1]
In vitro試験 NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMK MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv3VmlwUUN3ME2wMlAxODF{NTFOwG0> MWPTRW5ITVJ?
MV-4-11 M3HW[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D4T2lEPTB;MD6wNFA2PThizszN NGr4TXJUSU6JRWK=
NALM-6 MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMECwPFQzKM7:TR?= NF7ncJdUSU6JRWK=
HOS NGDwXFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLQTWM2OD1yLkCwNVM5KM7:TR?= NFP5ZlZUSU6JRWK=
HT-144 NEnr[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j1SWlEPTB;MD6wNFE2PSEQvF2= NGn2ZodUSU6JRWK=
SW1710 M3j1fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUiwOXRYUUN3ME2wMlAxOTh4IN88US=> NFL0fVZUSU6JRWK=
TE-8 NUfE[|FIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPLTWM2OD1yLkCwNlM4KM7:TR?= NWDvSpltW0GQR1XS
ES1 MlXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULiWGJvUUN3ME2wMlAxOjZ4IN88US=> MoTnV2FPT0WU
CCF-STTG1 M3:3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO0fmpKSzVyPUCuNFAzQTdizszN NHrtUXlUSU6JRWK=
PSN1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr2VoJKSzVyPUCuNFA{OThizszN NFH4SHVUSU6JRWK=
CAL-51 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMECzNlUh|ryP Moe3V2FPT0WU
MCF7 NX3Mb4ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMECzN|Uh|ryP NVXZR2FRW0GQR1XS
SK-HEP-1 MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfnWFZ2UUN3ME2wMlAxOzN4IN88US=> MVHTRW5ITVJ?
LCLC-103H M4P6XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEC0N{DPxE1? M{f4RnNCVkeHUh?=
HMV-II MljHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33JbGlEPTB;MD6wNFQ1QSEQvF2= M2PYSHNCVkeHUh?=
MES-SA NGW1U|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr3S5NKSzVyPUCuNFA1PTJizszN NF7KO2FUSU6JRWK=
SK-LMS-1 MonXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3KPGtKSzVyPUCuNFA1PThizszN MWfTRW5ITVJ?
639-V MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvnTWM2OD1yLkCwOFg2KM7:TR?= NVHXW3VwW0GQR1XS
SIG-M5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\ZTWM2OD1yLkCwOFg6KM7:TR?= NFvTWnlUSU6JRWK=
LOUCY MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf0TWM2OD1yLkCwOVA2KM7:TR?= NHXtVFVUSU6JRWK=
HSC-2 NUHZfFdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHvRpVWUUN3ME2wMlAxPTF6IN88US=> MYnTRW5ITVJ?
EW-13 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEC1NVgh|ryP MmrBV2FPT0WU
RT-112 NEnBNllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTMb4tKSzVyPUCuNFA2OzVizszN NGf0do5USU6JRWK=
NKM-1 M{\qd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfCS3RsUUN3ME2wMlAxPTR5IN88US=> Mnu1V2FPT0WU
KYSE-180 MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Pt[2lEPTB;MD6wNFU5PiEQvF2= M3;oRXNCVkeHUh?=
SW1783 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELFbW1KSzVyPUCuNFA2QTFizszN NYC5dohxW0GQR1XS
A431 M17P[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXpTWM2OD1yLkCwOlA4KM7:TR?= NWfwN4ZbW0GQR1XS
SK-OV-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFG0OVRKSzVyPUCuNFA3OyEQvF2= MWXTRW5ITVJ?
RPMI-7951 MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLFdIdKSzVyPUCuNFA3OzFizszN Mn3TV2FPT0WU
Capan-2 MkTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3SyUGlEPTB;MD6wNFY{QCEQvF2= NYntb|VNW0GQR1XS
HSC-3 NXnGeHd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rHNGlEPTB;MD6wNFY1OSEQvF2= MUjTRW5ITVJ?
786-0 M2LhRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;mbWlEPTB;MD6wNFY3OyEQvF2= NYrrW2R4W0GQR1XS
Daoy MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\NSXlKSzVyPUCuNFA3QTVizszN NUmxe4lUW0GQR1XS
KGN MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DjNWlEPTB;MD6wNFcxOyEQvF2= NITNOItUSU6JRWK=
EW-16 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEC3OFkh|ryP MYDTRW5ITVJ?
EW-7 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfK[|dKSzVyPUCuNFA4PTRizszN M1jkZXNCVkeHUh?=
IGROV-1 NUDQfldYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXmcW5KSzVyPUCuNFA5OTRizszN M370SXNCVkeHUh?=
8505C NUHmUJpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3izdWlEPTB;MD6wNFgzOSEQvF2= MYLTRW5ITVJ?
RKO M1TkU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEC4NlYh|ryP MlfTV2FPT0WU
GDM-1 NVzjVpFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\iT|hKSzVyPUCuNFA5PCEQvF2= NVXY[ldWW0GQR1XS
IST-MEL1 M2TGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDQWpNKSzVyPUCuNFA5PTJizszN NILlZ5lUSU6JRWK=
RPMI-6666 M3XQZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPXTWM2OD1yLkCwPFUzKM7:TR?= NVrDZnBqW0GQR1XS
SNG-M NGfFfXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXP3[49HUUN3ME2wMlAxQDV4IN88US=> NWPKUGdRW0GQR1XS
KS-1 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEC4OVkh|ryP NY\zcm5yW0GQR1XS
RXF393 NGHFWpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP4e|VKSzVyPUCuNFA5PiEQvF2= NHjKfIJUSU6JRWK=
CAL-12T M4nmTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H1S2lEPTB;MD6wNFkzOiEQvF2= M3WzPXNCVkeHUh?=
BFTC-905 NIjQXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvSU41KSzVyPUCuNFA6OzhizszN M1;2enNCVkeHUh?=
SK-MES-1 MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlruTWM2OD1yLkCwPVQ2KM7:TR?= M13nUHNCVkeHUh?=
BB30-HNC NF7OU4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nlbGlEPTB;MD6wNFk2OiEQvF2= NFq2WVZUSU6JRWK=
AN3-CA NXLkdIJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\wS4d1UUN3ME2wMlAyODF5IN88US=> NXP2XndDW0GQR1XS
EFO-27 NWjib5QyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\GPGlEPTB;MD6wNVAyPyEQvF2= NVnEPY1WW0GQR1XS
G-401 NUDhcW9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnzTWM2OD1yLkCxNFI2KM7:TR?= MVnTRW5ITVJ?
BPH-1 M1jqbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzKNWR3UUN3ME2wMlAyODNizszN NI\ZUlFUSU6JRWK=
NCI-H727 M1u0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj3TWM2OD1yLkCxNFMh|ryP Mk\oV2FPT0WU
SNU-423 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLZTWM2OD1yLkCxNFU{KM7:TR?= MnP3V2FPT0WU
KYSE-270 NGHlcYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XKV2lEPTB;MD6wNVA2QSEQvF2= MX;TRW5ITVJ?
AGS M1zHNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW1N4FKSzVyPUCuNFExPjFizszN MV3TRW5ITVJ?
NCI-H2228 NXHUfFBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnCZ4pKSzVyPUCuNFExPjRizszN NEKyXYRUSU6JRWK=
SW954 Mmf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HoRmlEPTB;MD6wNVA4OSEQvF2= NWnHTndMW0GQR1XS
769-P NYD4UoN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TR[2lEPTB;MD6wNVA4OyEQvF2= NUfkRVZiW0GQR1XS
BB49-HNC NELSR2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTidHl3UUN3ME2wMlAyODd5IN88US=> M2PNcHNCVkeHUh?=
IA-LM M3XHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XCUGlEPTB;MD6wNVA5PiEQvF2= NVrnR2ZyW0GQR1XS
NB69 NWfZcmMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEGxNFIh|ryP NIrob4NUSU6JRWK=
C8166 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e0TGlEPTB;MD6wNVEzQSEQvF2= M1LlWXNCVkeHUh?=
NCI-H1299 NUTSTXJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\LTWM2OD1yLkCxNVU1KM7:TR?= MYTTRW5ITVJ?
YKG-1 NGL2cI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHVOJpKSzVyPUCuNFEyPiEQvF2= M1PEXXNCVkeHUh?=
PANC-03-27 NGTs[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEGxOlIh|ryP NWG0TnhPW0GQR1XS
YT M1\adWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEGxO|kh|ryP MkTRV2FPT0WU
CAL-85-1 NIHrPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[wTWM2OD1yLkCxNVkzKM7:TR?= M33KdXNCVkeHUh?=
GT3TKB NVr2TI9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzTNJpKSzVyPUCuNFEzODJizszN NETKepJUSU6JRWK=
BB65-RCC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLSZnVKSzVyPUCuNFEzODRizszN NWjBdG9tW0GQR1XS
ES6 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEKxdW1KSzVyPUCuNFEzPjFizszN NV\xco5EW0GQR1XS
MHH-ES-1 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEGyOlMh|ryP MnnVV2FPT0WU
QIMR-WIL NIDCRZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTWTWM2OD1yLkCxNlY6KM7:TR?= NVXSZW1IW0GQR1XS
SNU-C2B Ml;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu2RoFJUUN3ME2wMlAyOjd{IN88US=> NIrydndUSU6JRWK=
OCI-AML2 MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3W2cWlEPTB;MD6wNVI5OSEQvF2= Mny0V2FPT0WU
DU-145 NVrCWY13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDCc4R3UUN3ME2wMlAyOjlizszN NYHCRVFGW0GQR1XS
SW982 NH[2O4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojvTWM2OD1yLkCxNlk{KM7:TR?= MWrTRW5ITVJ?
MFH-ino NYDUO|J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEGyPVMh|ryP MYrTRW5ITVJ?
A427 NVPDPXBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrJTWM2OD1yLkCxNlk6KM7:TR?= MUTTRW5ITVJ?
LCLC-97TM1 M2HqVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEGzJO69VQ>? Mm\rV2FPT0WU
AM-38 NHm5UZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HXXGlEPTB;MD6wNVMxOiEQvF2= NYLIN5g5W0GQR1XS
K5 NV\remR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGO5eXVKSzVyPUCuNFE{ODhizszN M4DScnNCVkeHUh?=
T84 NH\GZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f3[WlEPTB;MD6wNVM{OSEQvF2= MV;TRW5ITVJ?
TE-15 M{TjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETSVoZKSzVyPUCuNFE{OzZizszN NYDafZVJW0GQR1XS
NCI-H460 NEDuTXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEGzN|Yh|ryP M{XXR3NCVkeHUh?=
NTERA-S-cl-D1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHxb|lVUUN3ME2wMlAyOzN7IN88US=> NEm3VpFUSU6JRWK=
KYSE-450 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEGzOFkh|ryP NXviUZZZW0GQR1XS
H4 M3vzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\CdWlEPTB;MD6wNVM3PiEQvF2= NULVZXhDW0GQR1XS
LC-2-ad MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGqxfm9KSzVyPUCuNFE{PyEQvF2= NWe4eIl1W0GQR1XS
GAMG NHLOdY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XaSGlEPTB;MD6wNVM4OSEQvF2= M3LtNnNCVkeHUh?=
TK10 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLORVBKSzVyPUCuNFE{QDJizszN M1LBb3NCVkeHUh?=
NCI-H2122 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzWRphKSzVyPUCuNFE{QDRizszN MonKV2FPT0WU
KM12 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILiRYFKSzVyPUCuNFE{QTlizszN MnvXV2FPT0WU
CAL-39 M1r1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7CTWM2OD1yLkCxOFIh|ryP NGSwXGVUSU6JRWK=
RPMI-2650 M2DlVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7a[2ZPUUN3ME2wMlAyPDN{IN88US=> NFWzZVJUSU6JRWK=
KYSE-510 NHzWSWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEG0OFIh|ryP MX;TRW5ITVJ?
KALS-1 MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrITWM2OD1yLkCxOFY3KM7:TR?= MUDTRW5ITVJ?
NCI-H1648 M17xbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPtTWM2OD1yLkCxOFk6KM7:TR?= Mn[yV2FPT0WU
ES4 NHnIUWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[3WIJKSzVyPUCuNFE2ODJizszN Mk\jV2FPT0WU
C-33-A NWnwfYlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEG1NFkh|ryP NFfWOZNUSU6JRWK=
MIA-PaCa-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEG1NFkh|ryP M{\lVnNCVkeHUh?=
Becker M1K4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnqTWM2OD1yLkCxOVE1KM7:TR?= M4L3WHNCVkeHUh?=
HOP-62 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDyNHFKSzVyPUCuNFE2PDJizszN NHXTVZFUSU6JRWK=
TE-1 NXjIblJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEG1PFEh|ryP NXH6RoRVW0GQR1XS
KYSE-410 Ml\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHSxN5FKSzVyPUCuNFE2QDZizszN M{DwXHNCVkeHUh?=
NOS-1 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIKwem1KSzVyPUCuNFE2QTNizszN NFjKepBUSU6JRWK=
MEL-HO NFrRO2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvoR3JKSzVyPUCuNFE3PDNizszN Moq1V2FPT0WU
NCI-H1650 NXXkNVNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLRTWM2OD1yLkCxOlQ3KM7:TR?= MWfTRW5ITVJ?
VMRC-RCZ NXn0bZVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLNNZRKUUN3ME2wMlAyPjVzIN88US=> MoDwV2FPT0WU
HuP-T3 MonoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;3b5JKSzVyPUCuNFE3PTNizszN M4HENnNCVkeHUh?=
ACN NX3LOFZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTVbnNXUUN3ME2wMlAyPjV5IN88US=> M1XiSnNCVkeHUh?=
MEL-JUSO NHPxW2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPkOFJsUUN3ME2wMlAyPjhzIN88US=> NV65NlhFW0GQR1XS
HT-1197 NGnPOZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDjTWM2OD1yLkCxOlg2KM7:TR?= MUjTRW5ITVJ?
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22RV1 MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFu0XIFKSzVyPUCuNFM2ODdizszN NX\KVo9bW0GQR1XS
ES8 NFnScFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33FbGlEPTB;MD6wN|U{QCEQvF2= NELHXFdUSU6JRWK=
KYSE-150 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEO2NFgh|ryP NITjOGdUSU6JRWK=
HCC1569 MojZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rmc2lEPTB;MD6wN|YxQCEQvF2= NGqyWnNUSU6JRWK=
NB5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Lh[mlEPTB;MD6wN|YyOyEQvF2= Mn7kV2FPT0WU
G-402 NUTld2ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf0dYZKSzVyPUCuNFM3OTRizszN M1[0d3NCVkeHUh?=
NCI-H1693 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPKNIJKSzVyPUCuNFM3OTdizszN NXu0UndWW0GQR1XS
LB2241-RCC MlPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1yzNWlEPTB;MD6wN|Y1OiEQvF2= MmixV2FPT0WU
KP-4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEO2OlMh|ryP MWnTRW5ITVJ?
ML-2 NWjiXlE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1j6[WlEPTB;MD6wN|Y4OSEQvF2= M1\PVnNCVkeHUh?=
KU812 MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEO2PFQh|ryP MXLTRW5ITVJ?
LS-411N NYHYXphHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPkS5FKSzVyPUCuNFM4OzFizszN NI\1c5JUSU6JRWK=
OAW-42 NXflRWpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD2R5UzUUN3ME2wMlA{PzR5IN88US=> NEDDcpFUSU6JRWK=
HCC38 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;ETW5KSzVyPUCuNFM4PzFizszN NIP6[ZVUSU6JRWK=
Ca-Ski M1nNR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEO3PFQh|ryP NF\HcldUSU6JRWK=
Calu-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HiNWlEPTB;MD6wN|c5QSEQvF2= MkSzV2FPT0WU
KYSE-70 MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHva[25KSzVyPUCuNFM5OTJizszN MVfTRW5ITVJ?
D-392MG NUi3dXo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13KZWlEPTB;MD6wN|g1OiEQvF2= NIn1T2pUSU6JRWK=
OVCAR-4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfKN|NmUUN3ME2wMlA{QDV6IN88US=> NGnsWXNUSU6JRWK=
Detroit562 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fJSmlEPTB;MD6wN|g4OiEQvF2= MWjTRW5ITVJ?
HEL MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq2TWM2OD1yLkCzPFkyKM7:TR?= MkXwV2FPT0WU
MONO-MAC-6 Mlv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\w[494UUN3ME2wMlA{QDl|IN88US=> MnzaV2FPT0WU
LoVo MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoizTWM2OD1yLkCzPVM{KM7:TR?= M4\ic3NCVkeHUh?=
U-2-OS NWrk[5FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnGSWFQUUN3ME2wMlA{QTN3IN88US=> M{jsS3NCVkeHUh?=
A172 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:wS3lKSzVyPUCuNFM6PSEQvF2= NIHVcHRUSU6JRWK=
OCUB-M NUD1Rmk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr1TWM2OD1yLkCzPVYyKM7:TR?= MkS4V2FPT0WU
SW48 NEG5UmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4L3NmlEPTB;MD6wOFA{OSEQvF2= MUXTRW5ITVJ?
HC-1 NWjMZnM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMESwOlkh|ryP MWjTRW5ITVJ?
KOSC-2 NW\sSWxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\BcVZDUUN3ME2wMlA1OTFizszN NFzFdIJUSU6JRWK=
HDLM-2 MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXQcoNKSzVyPUCuNFQyOTRizszN NVHuV3FWW0GQR1XS
CTV-1 MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH73TWRKSzVyPUCuNFQyOTZizszN M3mwe3NCVkeHUh?=
SH-4 NIHyV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T6OmlEPTB;MD6wOFE1OSEQvF2= M37NN3NCVkeHUh?=
SW756 M37UWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnOWmFQUUN3ME2wMlA1OTV5IN88US=> NXrKOII4W0GQR1XS
GCT MmX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMESxOlEh|ryP NUL0dW9xW0GQR1XS
CHL-1 NYDnS|J7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXvTWM2OD1yLkC0NVY6KM7:TR?= MX;TRW5ITVJ?
LAMA-84 M13xb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXXPGxKSzVyPUCuNFQyPzFizszN NFXOO5lUSU6JRWK=
LS-1034 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrDWoNKSzVyPUCuNFQyQTFizszN NV\ENWdZW0GQR1XS
NCI-H358 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[xTWM2OD1yLkC0NlEzKM7:TR?= MVfTRW5ITVJ?
NB13 MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rF[2lEPTB;MD6wOFIzPyEQvF2= MUPTRW5ITVJ?
TE-9 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe3VIpKSzVyPUCuNFQzOzdizszN M4XTdHNCVkeHUh?=
OE33 NXvwfZhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfmSmpxUUN3ME2wMlA1OjRzIN88US=> NEjGSVJUSU6JRWK=
CAL-120 NGTsSXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n5cmlEPTB;MD6wOFI1OSEQvF2= NXS4SGdNW0GQR1XS
DJM-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMESyO|Ih|ryP MXLTRW5ITVJ?
SK-MEL-24 NWXnZXp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTPSYtTUUN3ME2wMlA1Ojh|IN88US=> NYOzfo9UW0GQR1XS
VA-ES-BJ NUTYUVVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7KTGVKSzVyPUCuNFQzQTJizszN NUDnOFRjW0GQR1XS
MMAC-SF MkXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13NbGlEPTB;MD6wOFI6PyEQvF2= MmXiV2FPT0WU
MZ7-mel NHLMbnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{frdGlEPTB;MD6wOFM{KM7:TR?= M3S5OnNCVkeHUh?=
BxPC-3 M{PR[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjHUIhKUUN3ME2wMlA1OzRzIN88US=> MlH4V2FPT0WU
HT-29 NHnVWYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMESzOVch|ryP NXLuSWp6W0GQR1XS
SK-MEL-30 NFHERVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUewSo5tUUN3ME2wMlA1OzZ{IN88US=> M{PjUHNCVkeHUh?=
CAL-33 NFO1V25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2xTWM2OD1yLkC0N|c2KM7:TR?= MX7TRW5ITVJ?
COLO-680N M4jJUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID2O2VKSzVyPUCuNFQ1ODdizszN M1PHU3NCVkeHUh?=
NH-12 Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nnNmlEPTB;MD6wOFQ1KM7:TR?= MoP3V2FPT0WU
HCC1937 NWHYNVM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\lVYlKSzVyPUCuNFQ1PTZizszN M{LD[nNCVkeHUh?=
IMR-5 Mnn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HUfWlEPTB;MD6wOFQ6KM7:TR?= MlvuV2FPT0WU
MC-CAR MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G1N2lEPTB;MD6wOFU3QSEQvF2= Mn\hV2FPT0WU
NCI-H747 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\INmlEPTB;MD6wOFU4KM7:TR?= MWPTRW5ITVJ?
NCI-H1792 M2f5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\tTWM2OD1yLkC0OVgyKM7:TR?= NFfVNFdUSU6JRWK=
SW13 Mnf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMES1PUDPxE1? Mlr2V2FPT0WU
MLMA Mn6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PsemlEPTB;MD6wOFYxQSEQvF2= NWjsOHUzW0GQR1XS
U251 MnnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPZcmNKSzVyPUCuNFQ4PjNizszN MXXTRW5ITVJ?
U031 NVvSfYpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMES3O|Eh|ryP MXPTRW5ITVJ?
ME-180 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMES3PFIh|ryP MXXTRW5ITVJ?
SK-MEL-3 MkK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMES4NFIh|ryP MWPTRW5ITVJ?
MOLT-4 M3jXVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn6UYJKSzVyPUCuNFQ5ODNizszN MmPHV2FPT0WU
PF-382 M1jvWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPXTWM2OD1yLkC0PFI3KM7:TR?= NWfqeYQxW0GQR1XS
NUGC-3 NYrXUnd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG4e2xKSzVyPUCuNFQ5OjdizszN NGX1PINUSU6JRWK=
NCI-H1417 M3\QN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;3[JJKSzVyPUCuNFQ5QSEQvF2= NHe0Sm5USU6JRWK=
COLO-205 M1[0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mor2TWM2OD1yLkC0PVE6KM7:TR?= Ml:wV2FPT0WU
TE-441-T MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHOzfmZKSzVyPUCuNFQ6OyEQvF2= NXi5[pA1W0GQR1XS
MKN1 MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMES5N{DPxE1? NXyydZVnW0GQR1XS
UM-UC-3 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDX[XJKSzVyPUCuNFQ6PSEQvF2= NHLZRWZUSU6JRWK=
SF126 MoT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TUc2lEPTB;MD6wOVAyKM7:TR?= NEXKdWVUSU6JRWK=
LB1047-RCC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEWwN|Eh|ryP MYrTRW5ITVJ?
A253 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfBTWM2OD1yLkC1NFUzKM7:TR?= M4\TbnNCVkeHUh?=
NCI-H1963 NYLjW4pnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[xTWM2OD1yLkC1NVc3KM7:TR?= Mn;jV2FPT0WU
VM-CUB-1 NEW3eHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEWzNVEh|ryP NUP3S4V[W0GQR1XS
T-24 NH7lU2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XhfGlEPTB;MD6wOVM5PCEQvF2= M4\mV3NCVkeHUh?=
K-562 Ml\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEWzPFch|ryP NXn1NmdiW0GQR1XS
ARH-77 NWLsbIlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrWeoFKSzVyPUCuNFU{QTVizszN NFvvW41USU6JRWK=
CA46 NIHNO|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\wTYpKSzVyPUCuNFU1OyEQvF2= NYLjRoI{W0GQR1XS
HCC70 NVjwWoRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEW0OVIh|ryP MnexV2FPT0WU
ST486 NHTBZ5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnFZnZKSzVyPUCuNFU2OjVizszN NX\wUW5yW0GQR1XS
COLO-741 NEPjeI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT3TWM2OD1yLkC1OVMyKM7:TR?= M2jpeHNCVkeHUh?=
SK-PN-DW NWDMWJVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLYe2l{UUN3ME2wMlA2PTh6IN88US=> M1\lO3NCVkeHUh?=
BL-41 NH;rdIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHpTWM2OD1yLkC1OVk3KM7:TR?= Mn3xV2FPT0WU
D-263MG M3G3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEW2PFMh|ryP MkPFV2FPT0WU
KE-37 MmnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEW2PFMh|ryP NVnOT4RrW0GQR1XS
LU-134-A NFjkVWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rhd2lEPTB;MD6wOVcyPSEQvF2= M1TJ[nNCVkeHUh?=
HCC2157 NHqxd2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjqVnNKSzVyPUCuNFU4OzNizszN MWfTRW5ITVJ?
GAK MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP4[5c6UUN3ME2wMlA2PzN2IN88US=> MUjTRW5ITVJ?
IST-SL2 NH3pS|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\neVRKSzVyPUCuNFU4PDNizszN NXnwWYNkW0GQR1XS
KMOE-2 NVXPcIh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfkTWM2OD1yLkC1O|Q6KM7:TR?= NETUUGdUSU6JRWK=
SW1573 M1TxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\OO2lEPTB;MD6wOVgxOiEQvF2= NYjCeFdwW0GQR1XS
SCC-9 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEW4O{DPxE1? NHOxRllUSU6JRWK=
MDA-MB-361 NHHwSIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\H[pJKSzVyPUCuNFU5PzJizszN MnjyV2FPT0WU
BHT-101 NWWy[XpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jLN2lEPTB;MD6wOVg4PiEQvF2= NEDHZZlUSU6JRWK=
NCI-H1770 NIjjNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPQNnQ6UUN3ME2wMlA2QDd7IN88US=> NH70dopUSU6JRWK=
UACC-893 NYiydpBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PRfmlEPTB;MD6wOVg6PiEQvF2= Ml;ZV2FPT0WU
NCI-H226 NFL1e2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrtTWM2OD1yLkC1PVg5KM7:TR?= MonxV2FPT0WU
HLE Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fo[mlEPTB;MD6wOlA5OiEQvF2= MYHTRW5ITVJ?
NCI-H1703 NIHFPHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW1TWM2OD1yLkC2NVc5KM7:TR?= MojoV2FPT0WU
KURAMOCHI NEiwW4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moi1TWM2OD1yLkC2NVg6KM7:TR?= MkLrV2FPT0WU
RH-1 NVTnV2VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrzUI5KSzVyPUCuNFYzOyEQvF2= M3[2T3NCVkeHUh?=
DSH1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vDOWlEPTB;MD6wOlI4KM7:TR?= NG\HSFVUSU6JRWK=
CAMA-1 MmH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLxTWM2OD1yLkC2N|A{KM7:TR?= MULTRW5ITVJ?
NCI-H1437 MlvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHZTWM2OD1yLkC2N|I5KM7:TR?= NWHYSHBKW0GQR1XS
HuP-T4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwME[1PFYh|ryP Mlf2V2FPT0WU
HCT-15 MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7pO5BKSzVyPUCuNFY2QTdizszN NYjaflZmW0GQR1XS
NCCIT MmnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwME[2NFQh|ryP NVXwSW56W0GQR1XS
BOKU MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInUTmFKSzVyPUCuNFY3PzRizszN MU\TRW5ITVJ?
FADU MlzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn75TWM2OD1yLkC2O|Q2KM7:TR?= NFnHVpNUSU6JRWK=
SUP-T1 M4jxXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XKV2lEPTB;MD6wOlc3KM7:TR?= NGrXdnZUSU6JRWK=
L-363 NF\RZpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jUfWlEPTB;MD6wOlkxOSEQvF2= NY[yXopCW0GQR1XS
KNS-81-FD MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XLcmlEPTB;MD6wOlkyQCEQvF2= NFfkVHdUSU6JRWK=
SU-DHL-1 MkS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG4PIRQUUN3ME2wMlA3QTJizszN M3LzSHNCVkeHUh?=
HuH-7 NHvRd2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nqe2lEPTB;MD6wO|A{PSEQvF2= Mn7JV2FPT0WU
BT-474 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEewOlEh|ryP NULqe3c1W0GQR1XS
CAPAN-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDzTWM2OD1yLkC3NVQ{KM7:TR?= NFvGc2JUSU6JRWK=
HEC-1 M{G3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPkbpVKSzVyPUCuNFcyPjFizszN Mme5V2FPT0WU
NOMO-1 NUnIeWpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPiW2xKSzVyPUCuNFcyPzJizszN NEHlOYdUSU6JRWK=
KM-H2 M2fuRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX1TWM2OD1yLkC3NlQyKM7:TR?= NUW5ZZVYW0GQR1XS
EB2 NXPqNY9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHy1Om9KSzVyPUCuNFczQDVizszN MXTTRW5ITVJ?
LU-99A NULzdFdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L2NWlEPTB;MD6wO|I5PyEQvF2= MmHHV2FPT0WU
WSU-NHL NYDn[21KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vve2lEPTB;MD6wO|MzQSEQvF2= NYLUb5JWW0GQR1XS
Calu-1 NIrl[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEezN|Ih|ryP NV7uT3pPW0GQR1XS
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RL M4H0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMkixO|Qh|ryP M{jUO3NCVkeHUh?=
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NCI-H510A NX6wU2hpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nYU2lEPTB;MD6yPVMxPCEQvF2= MYTTRW5ITVJ?
Mo-T NFr2O5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DadmlEPTB;MD6yPVM{OSEQvF2= NH;IdlVUSU6JRWK=
LB373-MEL-D NE\jVHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnpVWc1UUN3ME2wMlI6PDNzIN88US=> NGP1fJlUSU6JRWK=
NCI-H28 NIrxWHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMkm4N|ch|ryP MX3TRW5ITVJ?
NCI-H446 NXPMcllFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLBN3RuUUN3ME2wMlI6QTJzIN88US=> M2DtO3NCVkeHUh?=
L-540 NFXtWXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Lab2lEPTB;MD6zNFA5QSEQvF2= MWfTRW5ITVJ?
MKN7 NFH0b4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF25[4RKSzVyPUCuN|A3OzlizszN NVXtelRHW0GQR1XS
OPM-2 NEn0WXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwM{GwOlQh|ryP MlPxV2FPT0WU
BT-20 NV\wSVk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwM{GwPVkh|ryP NEOyNY1USU6JRWK=
KP-N-YN M3[3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXsW29KSzVyPUCuN|EyOThizszN NIjmV3dUSU6JRWK=
MDA-MB-175-VII NV;lc4VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\ObmlKSzVyPUCuN|I{PDhizszN MVvTRW5ITVJ?
EFM-19 M{[4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXhTWM2OD1yLkOzNVMzKM7:TR?= MkDmV2FPT0WU
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A704 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7qTWM2OD1yLkO0PVI{KM7:TR?= M3jpW3NCVkeHUh?=
NCI-H719 Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;OZWJKSzVyPUCuN|UyOjRizszN NXfxSnpGW0GQR1XS
MFE-280 NYnIVHZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3wXmNXUUN3ME2wMlM2PzF3IN88US=> NXHTOHYyW0GQR1XS
DMS-114 MmLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLRNlZKSzVyPUCuN|YyOiEQvF2= MYfTRW5ITVJ?
RMG-I M2fX[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG5[G5KSzVyPUCuN|Y3QTFizszN M4\DenNCVkeHUh?=
SK-N-FI MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmG2TWM2OD1yLkO3OlM4KM7:TR?= NFrEZlhUSU6JRWK=
LB2518-MEL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;GTWM2OD1yLkSwPFczKM7:TR?= MVjTRW5ITVJ?
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HPAF-II M2fDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwNEGxNVch|ryP M3jsXnNCVkeHUh?=
NCI-H1882 NX\ufVE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPT[Y1jUUN3ME2wMlQyPzh2IN88US=> NWPmfVhrW0GQR1XS
JVM-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC5Z3ZKSzVyPUCuOFQ1ODFizszN MVrTRW5ITVJ?
T47D NV;HWphXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwNES1Nlgh|ryP MX7TRW5ITVJ?
MHH-CALL-2 NHG1dmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq2dW5KSzVyPUCuOFQ5OyEQvF2= M{\OOnNCVkeHUh?=
NCI-H716 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf4c5ZkUUN3ME2wMlQ1QDR6IN88US=> MXPTRW5ITVJ?
NEC8 MoDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPVR3lKSzVyPUCuOFUyPDVizszN MVPTRW5ITVJ?
UACC-812 NV7SV3dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MluyTWM2OD1yLkS2O|c3KM7:TR?= M4\Md3NCVkeHUh?=
D-502MG M3G0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwNEiwN{DPxE1? MnrPV2FPT0WU
CaR-1 Ml3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PzTWlEPTB;MD61NFM3PyEQvF2= NEHVeJVUSU6JRWK=
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RPMI-8402 NHLldWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HLNGlEPTB;MD61NlIxPyEQvF2= NF\pPVdUSU6JRWK=
SW1088 M4\3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS4TWM2OD1yLkWzPFY6KM7:TR?= NYS0dWYxW0GQR1XS
JVM-3 M2D2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmxcpBMUUN3ME2wMlU1OTF5IN88US=> NXXITWtNW0GQR1XS
YAPC M3\QUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwNUWyNVEh|ryP NGTwZo1USU6JRWK=
KG-1 NEXVeJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\icGlEPTB;MD61OVk5PCEQvF2= M3\nVHNCVkeHUh?=
C32 NEft[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\OTWM2OD1yLkW3N|E{KM7:TR?= M1izdnNCVkeHUh?=
IST-SL1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwNkC0N|Uh|ryP MVzTRW5ITVJ?
NCI-H2126 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwNkOxOVIh|ryP MlnuV2FPT0WU
HCC1954 NITRT4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PrfmlEPTB;MD62OFczPiEQvF2= MX7TRW5ITVJ?
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TYK-nu MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2mzO2lEPTB;MD62O|k2OiEQvF2= M{fke3NCVkeHUh?=
KY821 NIn5WpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDJRZNKSzVyPUCuO|AzOjlizszN MYrTRW5ITVJ?
SIMA MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDETWM2OD1yLkexO|E6KM7:TR?= NWHvd3ZMW0GQR1XS
RCC10RGB MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwN{G5NVgh|ryP NVjVS3lrW0GQR1XS
LN-405 MmixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LlemlEPTB;MD63OFM3KM7:TR?= NHPl[5FUSU6JRWK=
NCI-H1155 NH;We4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzuTWM2OD1yLke0PFY5KM7:TR?= NGntdYxUSU6JRWK=
SCLC-21H NIPTWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr1XolYUUN3ME2wMlc3QTB|IN88US=> NWDoeGR[W0GQR1XS
DMS-79 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j0N2lEPTB;MD63O|g1PSEQvF2= NVjmWYpCW0GQR1XS
EC-GI-10 M{fZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLBO4xuUUN3ME2wMlc4QTd3IN88US=> MWnTRW5ITVJ?
KNS-42 Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwN{i4N|Eh|ryP NFvRVWlUSU6JRWK=
SNU-475 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwN{myNFIh|ryP NWrndo85W0GQR1XS
SF539 MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP3XWVKSzVyPUCuO|k6OjVizszN NV2ySJp2W0GQR1XS
SW1417 M{LhN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfDbXBKSzVyPUCuPFE{OzlizszN M2C5NnNCVkeHUh?=
ATN-1 NWXMTVNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjHUolKSzVyPUCuPFUyOTVizszN MV;TRW5ITVJ?
PLC-PRF-5 NFPmN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfiTWM2OD1yLki4OFc2KM7:TR?= NIrSfGlUSU6JRWK=
HT-3 NEnVbpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwOEm0NkDPxE1? MkezV2FPT0WU
MDA-MB-453 NFHqbItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvxd3lZUUN3ME2wMlkxOzB2IN88US=> NGTkOYtUSU6JRWK=
HAL-01 MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXJTWM2OD1yLkm5N|c6KM7:TR?= MVLTRW5ITVJ?
NCI-H1993 M{nMU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTFwMES2OVch|ryP MmXyV2FPT0WU
NCI-H2227 M1vRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P4TWlEPTB;MT6wOFk5OSEQvF2= NU\N[3FqW0GQR1XS
LP-1 M3vn[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXETWM2OD1zLkC2PVMh|ryP MX\TRW5ITVJ?
P31-FUJ NV3TPYxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vwSmlEPTB;MT6xNFc3PiEQvF2= NYrkepNVW0GQR1XS
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SW1463 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfyN5lCUUN3ME2xMlE5OzR7IN88US=> MmjFV2FPT0WU
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TALL-1 NYnpbWFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj4[5RKSzVyPUGuNlUyPjVizszN M3zyfHNCVkeHUh?=
RO82-W-1 NWn5RpdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rO[GlEPTB;MT6zN|M{QSEQvF2= M3K4eXNCVkeHUh?=
NCI-H1581 NIDW[|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTubmJjUUN3ME2xMlM2Pjh5IN88US=> M{fHb3NCVkeHUh?=
NCI-H748 M{Pifmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFwM{W3N|gh|ryP NXPPVodEW0GQR1XS
HCC1187 M1\2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW0TWM2OD1zLkW1OVIzKM7:TR?= NFfTfYFUSU6JRWK=
EoL-1-cell NH;LcmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXqTWM2OD1zLkW4PFg6KM7:TR?= NE\2eplUSU6JRWK=
HuO-3N1 M1TTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTFwOEO0NVIh|ryP Mk\EV2FPT0WU
NCI-H1793 MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISybIJKSzVyPUGuPFc2QTNizszN MUDTRW5ITVJ?
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... Click to View More Cell Line Experimental Data

In vivo試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

細胞アッセイ: [1]

細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

動物実験: [3]

動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
製剤 In DMSO and diluted in sterile saline/Tween 20
投薬量 50 mg/kg
投与方法 Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Luminespib (AUY-922, NVP-AUY922) SDF
分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管 3年-20℃
2年-80℃in solvent
別名 VER-52296
溶解度 (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water <1 mg/mL
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

文献中の引用 (23)

技術サポート&よくある質問(FAQ)

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* 必須

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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