Luminespib (AUY-922, NVP-AUY922) 化学構造
分子量: 465.54

高品質保証

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Quality Control & MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野
  • Luminespib (AUY-922, NVP-AUY922)のメカニズム

製品の説明

生物活性

製品説明 Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。
ターゲット HSP90α HSP90β
IC50 13 nM 21 nM [1]
In vitro試験 NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. [1] The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of HSP90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to HSP90. NVP-AUY922 causes p23 dissociation from the HSP90 complex and can then recruit HSP70 to the HSP90 complex. [1] After the treatment with NVP-AUY922, expression of receptor tyrosine kinases including VEGFR1, 2, 3 and PDGFRɑ is decreased. A decrease is also noticed in the expression of Akt and phospho-Akt. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of HSP90 to client proteins and setting them up as targets for degradation by the proteasome. NVP-AUY922 can influence cell growth by affecting multiple signaling pathways. In addition, treatment with the proteasome inhibitor, MG132, restores expression of thymidylate synthase, which is decreased by NVP-AUY922. NVP-AUY922 increases the expression of cleaved caspase-3 leading to apoptosis in HSC-2 cells.[1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
CMK MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMECwNVI2KM7:TR?= NVTlT2kyW0GQR1XS
MV-4-11 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMECwOVU5KM7:TR?= NHnaUnhUSU6JRWK=
NALM-6 NEPUeoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG4UI5KSzVyPUCuNFAxQDR{IN88US=> MUPTRW5ITVJ?
HOS M2DO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDtZ3hKSzVyPUCuNFAyOzhizszN MVHTRW5ITVJ?
HT-144 MoDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW1TWM2OD1yLkCwNVU2KM7:TR?= NVfQfZZKW0GQR1XS
SW1710 NFi2bZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLDU2NMUUN3ME2wMlAxOTh4IN88US=> NEDzNXdUSU6JRWK=
TE-8 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX4NpFKSzVyPUCuNFAzOzdizszN NY\SWG53W0GQR1XS
ES1 NVX4PGNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMECyOlYh|ryP NVK4O3NHW0GQR1XS
CCF-STTG1 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX3UZlKSzVyPUCuNFAzQTdizszN MnXQV2FPT0WU
PSN1 M{CwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMECzNVgh|ryP MkHQV2FPT0WU
CAL-51 M1n6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHpNZFtUUN3ME2wMlAxOzJ3IN88US=> MoP5V2FPT0WU
MCF7 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3C[m5KSzVyPUCuNFA{OzVizszN MUfTRW5ITVJ?
SK-HEP-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\p[mlEPTB;MD6wNFM{PiEQvF2= NVe4WHhoW0GQR1XS
LCLC-103H NFLMcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjyeGZDUUN3ME2wMlAxPDNizszN M3P3NHNCVkeHUh?=
HMV-II MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P0XmlEPTB;MD6wNFQ1QSEQvF2= NYjsTIdxW0GQR1XS
MES-SA MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMEC0OVIh|ryP MX;TRW5ITVJ?
SK-LMS-1 NH7TT5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEC0OVgh|ryP NGTqOI5USU6JRWK=
639-V MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEC0PFUh|ryP M1\HV3NCVkeHUh?=
SIG-M5 NHTqd3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMEC0PFkh|ryP NF;tVZlUSU6JRWK=
LOUCY NVThcJB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjyVoZKSzVyPUCuNFA2ODVizszN MWDTRW5ITVJ?
HSC-2 M3nGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGntZo1KSzVyPUCuNFA2OThizszN M3PifXNCVkeHUh?=
EW-13 NXO4c4dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMEC1NVgh|ryP NFPqUWNUSU6JRWK=
RT-112 NELDc5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\MNW5KSzVyPUCuNFA2OzVizszN NXGxNHdQW0GQR1XS
NKM-1 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEC1OFch|ryP MX;TRW5ITVJ?
KYSE-180 MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMEC1PFYh|ryP NUPQSI1lW0GQR1XS
SW1783 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfKTWM2OD1yLkCwOVkyKM7:TR?= MVXTRW5ITVJ?
A431 M3nVfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEC2NFch|ryP NXf3dlhQW0GQR1XS
SK-OV-3 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfROYhKSzVyPUCuNFA3OyEQvF2= MXTTRW5ITVJ?
RPMI-7951 NY\J[ZRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfPTWM2OD1yLkCwOlMyKM7:TR?= M1e5enNCVkeHUh?=
Capan-2 Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jGOWlEPTB;MD6wNFY{QCEQvF2= NWnWbnBjW0GQR1XS
HSC-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H2dWlEPTB;MD6wNFY1OSEQvF2= M{jFbXNCVkeHUh?=
786-0 MkO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz6cnlWUUN3ME2wMlAxPjZ|IN88US=> MV;TRW5ITVJ?
Daoy NWXrcnpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDNTWM2OD1yLkCwOlk2KM7:TR?= NY\TOFh1W0GQR1XS
KGN MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mom5TWM2OD1yLkCwO|A{KM7:TR?= NFPZ[VFUSU6JRWK=
EW-16 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMEC3OFkh|ryP M4rXVXNCVkeHUh?=
EW-7 M3X1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEC3OVQh|ryP MV\TRW5ITVJ?
IGROV-1 M4nafmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\ETWM2OD1yLkCwPFE1KM7:TR?= NET0Rm1USU6JRWK=
8505C MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLENHVKSzVyPUCuNFA5OjFizszN MmjiV2FPT0WU
RKO MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEC4NlYh|ryP MXnTRW5ITVJ?
GDM-1 M3XUSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rnV2lEPTB;MD6wNFg1KM7:TR?= NYnuWpZnW0GQR1XS
IST-MEL1 MlfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrZTWM2OD1yLkCwPFUzKM7:TR?= MUDTRW5ITVJ?
RPMI-6666 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\TTWM2OD1yLkCwPFUzKM7:TR?= MkDCV2FPT0WU
SNG-M MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXkTWM2OD1yLkCwPFU3KM7:TR?= MmXMV2FPT0WU
KS-1 M4fSVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDWTWM2OD1yLkCwPFU6KM7:TR?= NUDXS5FxW0GQR1XS
RXF393 NXfkco5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1W3[WlEPTB;MD6wNFg3KM7:TR?= NVPWcXA6W0GQR1XS
CAL-12T M2fDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XWdGlEPTB;MD6wNFkzOiEQvF2= MX;TRW5ITVJ?
BFTC-905 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLBWHc3UUN3ME2wMlAxQTN6IN88US=> NE\vUYxUSU6JRWK=
SK-MES-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\2cWlEPTB;MD6wNFk1PSEQvF2= NWXZVFdjW0GQR1XS
BB30-HNC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjXSXI1UUN3ME2wMlAxQTV{IN88US=> NIHOdWtUSU6JRWK=
AN3-CA NHjGPZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEGwNVch|ryP MWLTRW5ITVJ?
EFO-27 M17uXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX0b49jUUN3ME2wMlAyODF5IN88US=> Ml;PV2FPT0WU
G-401 Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;r[YJKSzVyPUCuNFExOjVizszN M2XPdHNCVkeHUh?=
BPH-1 NFfSPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPGd4dKSzVyPUCuNFExOyEQvF2= MnXNV2FPT0WU
NCI-H727 Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnvSFhKSzVyPUCuNFExOyEQvF2= NHSzc2xUSU6JRWK=
SNU-423 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;5S3RlUUN3ME2wMlAyODV|IN88US=> MnHlV2FPT0WU
KYSE-270 NH\FV41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\keodbUUN3ME2wMlAyODV7IN88US=> MUDTRW5ITVJ?
AGS M2K4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS1RVFSUUN3ME2wMlAyODZzIN88US=> NYq3SItIW0GQR1XS
NCI-H2228 M4H1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XvRmlEPTB;MD6wNVA3PCEQvF2= NEPiZXNUSU6JRWK=
SW954 MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O0NWlEPTB;MD6wNVA4OSEQvF2= NWL5UGh3W0GQR1XS
769-P NWq4UHNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEGwO|Mh|ryP M375T3NCVkeHUh?=
BB49-HNC NInjV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\s[GlEPTB;MD6wNVA4PyEQvF2= M1roNnNCVkeHUh?=
IA-LM M2WxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEGwPFYh|ryP NFnm[XBUSU6JRWK=
NB69 NYPvNVlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHTTWM2OD1yLkCxNVAzKM7:TR?= NF:5d5BUSU6JRWK=
C8166 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLtfZlKSzVyPUCuNFEyOjlizszN M1vadHNCVkeHUh?=
NCI-H1299 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvaTWM2OD1yLkCxNVU1KM7:TR?= NGnTU4RUSU6JRWK=
YKG-1 NVrjT5gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vTOWlEPTB;MD6wNVE3KM7:TR?= M2LlUXNCVkeHUh?=
PANC-03-27 NW\DcphCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfte5lKSzVyPUCuNFEyPjJizszN MlXqV2FPT0WU
YT MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PnSGlEPTB;MD6wNVE4QSEQvF2= MX;TRW5ITVJ?
CAL-85-1 NWr5d4k5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWm3[nBRUUN3ME2wMlAyOTl{IN88US=> NF71SphUSU6JRWK=
GT3TKB MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXFOnFKSzVyPUCuNFEzODJizszN MXHTRW5ITVJ?
BB65-RCC NVXBbFJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEGyNFQh|ryP M{LUbHNCVkeHUh?=
ES6 M4DJV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vtU2lEPTB;MD6wNVI3OSEQvF2= NXjOc5hyW0GQR1XS
MHH-ES-1 NEizO5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzaTWM2OD1yLkCxNlY{KM7:TR?= NVrXbWtCW0GQR1XS
QIMR-WIL Mn\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TpV2lEPTB;MD6wNVI3QSEQvF2= M3TyN3NCVkeHUh?=
SNU-C2B NIfqVGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHeybpdKSzVyPUCuNFEzPzJizszN M3XsVXNCVkeHUh?=
OCI-AML2 Mn:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;vfWlEPTB;MD6wNVI5OSEQvF2= NF72XmdUSU6JRWK=
DU-145 M2T1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPXPHJKSzVyPUCuNFEzQSEQvF2= NGG5ZmlUSU6JRWK=
SW982 M2HKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrvRZdKSzVyPUCuNFEzQTNizszN MoLCV2FPT0WU
MFH-ino MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon6TWM2OD1yLkCxNlk{KM7:TR?= NW\N[IRIW0GQR1XS
A427 MlXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\jdWhKSzVyPUCuNFEzQTlizszN NVrVcZJSW0GQR1XS
LCLC-97TM1 M4XKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXZTWM2OD1yLkCxN{DPxE1? M1zOUXNCVkeHUh?=
AM-38 M4TIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\3bFlKSzVyPUCuNFE{ODJizszN Mmn4V2FPT0WU
K5 NHPIcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFGxSGFKSzVyPUCuNFE{ODhizszN NFK2XGJUSU6JRWK=
T84 NHKyPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HZU2lEPTB;MD6wNVM{OSEQvF2= NYDtb3dpW0GQR1XS
TE-15 M4C4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInUTpNKSzVyPUCuNFE{OzZizszN M{jsUHNCVkeHUh?=
NCI-H460 M3XofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEGzN|Yh|ryP M1jmT3NCVkeHUh?=
NTERA-S-cl-D1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnjRo9PUUN3ME2wMlAyOzN7IN88US=> MVfTRW5ITVJ?
KYSE-450 NVPVeWhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLFSItKSzVyPUCuNFE{PDlizszN MU\TRW5ITVJ?
H4 NEGz[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYH4R3RWUUN3ME2wMlAyOzZ4IN88US=> MlL5V2FPT0WU
LC-2-ad MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzmTWM2OD1yLkCxN|ch|ryP NX7pRmFxW0GQR1XS
GAMG NE\XcW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfoNlZPUUN3ME2wMlAyOzdzIN88US=> NWe2NnpOW0GQR1XS
TK10 NGqyWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPrTYFZUUN3ME2wMlAyOzh{IN88US=> M4npNnNCVkeHUh?=
NCI-H2122 MlTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3xTWM2OD1yLkCxN|g1KM7:TR?= MVLTRW5ITVJ?
KM12 M{\a[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHkVHNKSzVyPUCuNFE{QTlizszN Mof2V2FPT0WU
CAL-39 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEG0NkDPxE1? NWHaZVFqW0GQR1XS
RPMI-2650 NULmTHE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;mSI1MUUN3ME2wMlAyPDN{IN88US=> NWPCZ2c1W0GQR1XS
KYSE-510 MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[5fZZKSzVyPUCuNFE1PDJizszN MVzTRW5ITVJ?
KALS-1 NEGyZo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLQTWM2OD1yLkCxOFY3KM7:TR?= NXHkTHJwW0GQR1XS
NCI-H1648 M1n0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEG0PVkh|ryP MWrTRW5ITVJ?
ES4 M3iwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP2TWM2OD1yLkCxOVAzKM7:TR?= NHHKZ29USU6JRWK=
C-33-A NUf5XlRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEG1NFkh|ryP NITi[XdUSU6JRWK=
MIA-PaCa-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn25TWM2OD1yLkCxOVA6KM7:TR?= MVHTRW5ITVJ?
Becker MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli4TWM2OD1yLkCxOVE1KM7:TR?= M33SeXNCVkeHUh?=
HOP-62 MljqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEG1OFIh|ryP MWLTRW5ITVJ?
TE-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEG1PFEh|ryP M2L5XHNCVkeHUh?=
KYSE-410 NHS4bW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\r[GlEPTB;MD6wNVU5PiEQvF2= MYPTRW5ITVJ?
NOS-1 NXT1WWxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEG1PVMh|ryP NF7IZ4lUSU6JRWK=
MEL-HO MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fmUmlEPTB;MD6wNVY1OyEQvF2= Mlr2V2FPT0WU
NCI-H1650 NXL3NpZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLuTWM2OD1yLkCxOlQ3KM7:TR?= Ml3QV2FPT0WU
VMRC-RCZ MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWewW3ljUUN3ME2wMlAyPjVzIN88US=> Ml3wV2FPT0WU
HuP-T3 M17rdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEG2OVMh|ryP NX3W[4NvW0GQR1XS
ACN NET1RllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXT[JJLUUN3ME2wMlAyPjV5IN88US=> NITpfVVUSU6JRWK=
MEL-JUSO Ml\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPL[2NKSzVyPUCuNFE3QDFizszN M4npPXNCVkeHUh?=
HT-1197 NXHkfHp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLod2JKSzVyPUCuNFE3QDVizszN MY\TRW5ITVJ?
NCI-H2030 NVrG[G5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3H2R2lEPTB;MD6wNVY6PyEQvF2= MUDTRW5ITVJ?
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DMS-273 NGTxdWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jiO2lEPTB;MD6wN|Q4QSEQvF2= NED0fZdUSU6JRWK=
22RV1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\BSHlKSzVyPUCuNFM2ODdizszN MmHyV2FPT0WU
ES8 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\3ZmhoUUN3ME2wMlA{PTN6IN88US=> MYfTRW5ITVJ?
KYSE-150 NVSw[G9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;tdmFsUUN3ME2wMlA{PjB6IN88US=> NHH4eYFUSU6JRWK=
HCC1569 M4C5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfISnF1UUN3ME2wMlA{PjB6IN88US=> NHfhcVhUSU6JRWK=
NB5 MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LyNmlEPTB;MD6wN|YyOyEQvF2= NHrDSZpUSU6JRWK=
G-402 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEO2NVQh|ryP Mn7OV2FPT0WU
NCI-H1693 NEG4blVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX0UVAxUUN3ME2wMlA{PjF5IN88US=> MlmyV2FPT0WU
LB2241-RCC MmGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvqTWM2OD1yLkCzOlQzKM7:TR?= MXjTRW5ITVJ?
KP-4 M2LPcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLuT5pKSzVyPUCuNFM3PjNizszN NVvxcVlIW0GQR1XS
ML-2 M1S3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ETWM2OD1yLkCzOlcyKM7:TR?= MnzkV2FPT0WU
KU812 NHrZU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;ZTWM2OD1yLkCzOlg1KM7:TR?= MnG0V2FPT0WU
LS-411N MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7kXpVzUUN3ME2wMlA{PzNzIN88US=> MnLYV2FPT0WU
OAW-42 NGHJNJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEO3OFch|ryP NHfuUYRUSU6JRWK=
HCC38 M1nSdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\KNWlEPTB;MD6wN|c4OSEQvF2= MWPTRW5ITVJ?
Ca-Ski M3G1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nKVWlEPTB;MD6wN|c5PCEQvF2= M{LVVnNCVkeHUh?=
Calu-3 NUntUXF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\GXVVlUUN3ME2wMlA{Pzh7IN88US=> M4jKNHNCVkeHUh?=
KYSE-70 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEO4NVIh|ryP M3\Ce3NCVkeHUh?=
D-392MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEO4OFIh|ryP MUTTRW5ITVJ?
OVCAR-4 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEO4OVgh|ryP NUXNZ3JvW0GQR1XS
Detroit562 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEO4O|Ih|ryP MVrTRW5ITVJ?
HEL M1;sWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;OTWM2OD1yLkCzPFkyKM7:TR?= MnHlV2FPT0WU
MONO-MAC-6 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXZfXRFUUN3ME2wMlA{QDl|IN88US=> MmL0V2FPT0WU
LoVo NW\XPWJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEO5N|Mh|ryP NYnDVHZpW0GQR1XS
U-2-OS NGqzSWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vHOWlEPTB;MD6wN|k{PSEQvF2= NX60WllXW0GQR1XS
A172 NHq4OmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zDNmlEPTB;MD6wN|k2KM7:TR?= M1f5[nNCVkeHUh?=
OCUB-M NF3tWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzETWM2OD1yLkCzPVYyKM7:TR?= M1S1V3NCVkeHUh?=
SW48 NHfJWotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW3d2VKSzVyPUCuNFQxOzFizszN NFnNXoVUSU6JRWK=
HC-1 M3vRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\UT2lEPTB;MD6wOFA3QSEQvF2= Mo[2V2FPT0WU
KOSC-2 NGT1XodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xy[2lEPTB;MD6wOFEyKM7:TR?= MX3TRW5ITVJ?
HDLM-2 NHnV[mVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\V[JVNUUN3ME2wMlA1OTF2IN88US=> M1zoS3NCVkeHUh?=
CTV-1 NH;xS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMESxNVYh|ryP MW\TRW5ITVJ?
SH-4 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvWbVVKSzVyPUCuNFQyPDFizszN NWq4bVVkW0GQR1XS
SW756 NILVV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK4XYZtUUN3ME2wMlA1OTV5IN88US=> NGLSbppUSU6JRWK=
GCT MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTSTWM2OD1yLkC0NVYyKM7:TR?= MX7TRW5ITVJ?
CHL-1 MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C4PGlEPTB;MD6wOFE3QSEQvF2= MXrTRW5ITVJ?
LAMA-84 M173[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fUNWlEPTB;MD6wOFE4OSEQvF2= MoXOV2FPT0WU
LS-1034 NYfUcXFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTwXHZLUUN3ME2wMlA1OTlzIN88US=> MXPTRW5ITVJ?
NCI-H358 MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXjTWM2OD1yLkC0NlEzKM7:TR?= MmTjV2FPT0WU
NB13 NGnRXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTtOlVsUUN3ME2wMlA1OjJ5IN88US=> MVvTRW5ITVJ?
TE-9 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3T0TGlEPTB;MD6wOFI{PyEQvF2= MULTRW5ITVJ?
OE33 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{KwWWlEPTB;MD6wOFI1OSEQvF2= MXzTRW5ITVJ?
CAL-120 NYrkbmo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFe5WWZKSzVyPUCuNFQzPDFizszN NXfRdol2W0GQR1XS
DJM-1 M{PtcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPhR|B{UUN3ME2wMlA1Ojd{IN88US=> NIDlbVNUSU6JRWK=
SK-MEL-24 NF\2SFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMESyPFMh|ryP M1nXcXNCVkeHUh?=
VA-ES-BJ NFrXTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j2UWlEPTB;MD6wOFI6OiEQvF2= M3vPW3NCVkeHUh?=
MMAC-SF MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjFNXhKSzVyPUCuNFQzQTdizszN NHvT[JRUSU6JRWK=
MZ7-mel MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrUfVNPUUN3ME2wMlA1OzNizszN NVzZXVdMW0GQR1XS
BxPC-3 M2fDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LROGlEPTB;MD6wOFM1OSEQvF2= MmPkV2FPT0WU
HT-29 NUnRO|BKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fseGlEPTB;MD6wOFM2PyEQvF2= MlHpV2FPT0WU
SK-MEL-30 NG\zeolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTJTWM2OD1yLkC0N|YzKM7:TR?= MlvJV2FPT0WU
CAL-33 NU\xbo91T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\CSZRsUUN3ME2wMlA1Ozd3IN88US=> MXHTRW5ITVJ?
COLO-680N NXHUdIM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDxZY9MUUN3ME2wMlA1PDB5IN88US=> MlTYV2FPT0WU
NH-12 NULGc5Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETyRYhKSzVyPUCuNFQ1PCEQvF2= MoDzV2FPT0WU
HCC1937 M1;aUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TpbGlEPTB;MD6wOFQ2PiEQvF2= NWG5cHp[W0GQR1XS
IMR-5 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvDT|FKSzVyPUCuNFQ1QSEQvF2= Mmf0V2FPT0WU
MC-CAR NWrmS4s5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjjV5FKSzVyPUCuNFQ2PjlizszN Mn6wV2FPT0WU
NCI-H747 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHiTWM2OD1yLkC0OVch|ryP NFOxVGNUSU6JRWK=
NCI-H1792 NW\YdYdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr4PFNKSzVyPUCuNFQ2QDFizszN MWLTRW5ITVJ?
SW13 NIfvW5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm1TWM2OD1yLkC0OVkh|ryP Mn3JV2FPT0WU
MLMA NFv4bnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXhTWM2OD1yLkC0OlA6KM7:TR?= MmPCV2FPT0WU
U251 NEP5dlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fJRWlEPTB;MD6wOFc3OyEQvF2= M13WUXNCVkeHUh?=
U031 NXPxUWFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nUbWlEPTB;MD6wOFc4OSEQvF2= M1vlbnNCVkeHUh?=
ME-180 M{LEb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMES3PFIh|ryP MVXTRW5ITVJ?
SK-MEL-3 NYTkeYhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TrPWlEPTB;MD6wOFgxOiEQvF2= M3fhenNCVkeHUh?=
MOLT-4 M{TwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojNTWM2OD1yLkC0PFA{KM7:TR?= M3i5PHNCVkeHUh?=
PF-382 MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMES4NlYh|ryP MV3TRW5ITVJ?
NUGC-3 MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnnO3dIUUN3ME2wMlA1QDJ5IN88US=> NVTBepBsW0GQR1XS
NCI-H1417 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MontTWM2OD1yLkC0PFkh|ryP MWHTRW5ITVJ?
COLO-205 M2P6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMES5NVkh|ryP Mmr3V2FPT0WU
TE-441-T NHj5U29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvPZnprUUN3ME2wMlA1QTNizszN Ml[1V2FPT0WU
MKN1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;zZWlEPTB;MD6wOFk{KM7:TR?= M2nabXNCVkeHUh?=
UM-UC-3 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHPdXFKSzVyPUCuNFQ6PSEQvF2= MUTTRW5ITVJ?
SF126 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzNTWM2OD1yLkC1NFEh|ryP NWTTV5dMW0GQR1XS
LB1047-RCC NH3VZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEWwN|Eh|ryP MVzTRW5ITVJ?
A253 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHMOoNKSzVyPUCuNFUxPTJizszN M4rXeXNCVkeHUh?=
NCI-H1963 NHLTd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17KS2lEPTB;MD6wOVE4PiEQvF2= NVfqNohGW0GQR1XS
VM-CUB-1 Moi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrjZ5Y2UUN3ME2wMlA2OzFzIN88US=> M3:xNHNCVkeHUh?=
T-24 NIXvVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEWzPFQh|ryP MXzTRW5ITVJ?
K-562 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrWXFU5UUN3ME2wMlA2Ozh5IN88US=> NISwW|VUSU6JRWK=
ARH-77 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMEWzPVUh|ryP MX\TRW5ITVJ?
CA46 MknNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELONJZKSzVyPUCuNFU1OyEQvF2= NXP1U2N4W0GQR1XS
HCC70 M3\TWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfLfVVCUUN3ME2wMlA2PDV{IN88US=> Mk\3V2FPT0WU
ST486 MluxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEW1NlUh|ryP MXHTRW5ITVJ?
COLO-741 MoPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjHTHRZUUN3ME2wMlA2PTNzIN88US=> MnfrV2FPT0WU
SK-PN-DW NXTjdFd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:wOWlEPTB;MD6wOVU5QCEQvF2= NHPFTo5USU6JRWK=
BL-41 M2fLVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEW1PVYh|ryP M2TJSHNCVkeHUh?=
D-263MG NF3ubGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknrTWM2OD1yLkC1Olg{KM7:TR?= Ml7wV2FPT0WU
KE-37 M1rRXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz1[|dKSzVyPUCuNFU3QDNizszN MVTTRW5ITVJ?
LU-134-A MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zmb2lEPTB;MD6wOVcyPSEQvF2= MYfTRW5ITVJ?
HCC2157 MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz4SpRKSzVyPUCuNFU4OzNizszN NHjybXNUSU6JRWK=
GAK NHvmOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEW3N|Qh|ryP Ml63V2FPT0WU
IST-SL2 NULabGlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr2[VREUUN3ME2wMlA2PzR|IN88US=> NFTPe4RUSU6JRWK=
KMOE-2 MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7STWM2OD1yLkC1O|Q6KM7:TR?= NEf6dFBUSU6JRWK=
SW1573 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\ZO4J1UUN3ME2wMlA2QDB{IN88US=> NIjYUW9USU6JRWK=
SCC-9 NH3YXHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEW4O{DPxE1? M133TnNCVkeHUh?=
MDA-MB-361 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrPUIp2UUN3ME2wMlA2QDd{IN88US=> M{\PcnNCVkeHUh?=
BHT-101 NUnjdGtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEW4O|Yh|ryP MXHTRW5ITVJ?
NCI-H1770 M4nmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEW4O|kh|ryP MkPFV2FPT0WU
UACC-893 M3exUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnLNpFuUUN3ME2wMlA2QDl4IN88US=> NHXD[GpUSU6JRWK=
NCI-H226 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7FSVdXUUN3ME2wMlA2QTh6IN88US=> NFmyZYRUSU6JRWK=
HLE MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLaVXk1UUN3ME2wMlA3ODh{IN88US=> M{XaS3NCVkeHUh?=
NCI-H1703 M3j2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEGy[pFKSzVyPUCuNFYyPzhizszN MUPTRW5ITVJ?
KURAMOCHI NH7DOGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mom1TWM2OD1yLkC2NVg6KM7:TR?= NWnlcIJbW0GQR1XS
RH-1 NV;Se|BrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\UdmlEPTB;MD6wOlI{KM7:TR?= MWTTRW5ITVJ?
DSH1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\OZ2lEPTB;MD6wOlI4KM7:TR?= Ml3NV2FPT0WU
CAMA-1 NV;OPGM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHuTWM2OD1yLkC2N|A{KM7:TR?= NXTMc5YyW0GQR1XS
NCI-H1437 M2T0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnz[5ZKSzVyPUCuNFY{OjhizszN NXzvW3g5W0GQR1XS
HuP-T4 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4C0fmlEPTB;MD6wOlU5PiEQvF2= NFv2[FlUSU6JRWK=
HCT-15 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\MTWM2OD1yLkC2OVk4KM7:TR?= M3npPHNCVkeHUh?=
NCCIT MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFSzTJVKSzVyPUCuNFY3ODRizszN M2jFSHNCVkeHUh?=
BOKU NUPET|VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXziemtqUUN3ME2wMlA3Pjd2IN88US=> NWXJS4hUW0GQR1XS
FADU NUHOWmRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwME[3OFUh|ryP NITlOXFUSU6JRWK=
SUP-T1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjSWnpbUUN3ME2wMlA3PzZizszN MlPOV2FPT0WU
L-363 NWrwXJI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XsXGlEPTB;MD6wOlkxOSEQvF2= NWeyUmxYW0GQR1XS
KNS-81-FD MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\kOWlEPTB;MD6wOlkyQCEQvF2= M3nifnNCVkeHUh?=
SU-DHL-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPBZ|dvUUN3ME2wMlA3QTJizszN NVLUZ294W0GQR1XS
HuH-7 NE\M[|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vUSmlEPTB;MD6wO|A{PSEQvF2= MnLVV2FPT0WU
BT-474 NH3ke5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv3TWM2OD1yLkC3NFYyKM7:TR?= M2rTOHNCVkeHUh?=
CAPAN-1 NUXydldbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXQWY1KSzVyPUCuNFcyPDNizszN NGPFOnZUSU6JRWK=
HEC-1 NXjYN25CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4i0SWlEPTB;MD6wO|E3OSEQvF2= M{TBS3NCVkeHUh?=
NOMO-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LHbmlEPTB;MD6wO|E4OiEQvF2= NY[3ZVBXW0GQR1XS
KM-H2 NGLmN29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LOemlEPTB;MD6wO|I1OSEQvF2= M2L0VXNCVkeHUh?=
EB2 MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDrTWM2OD1yLkC3Nlg2KM7:TR?= MoK5V2FPT0WU
LU-99A NIC2bpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrwTWM2OD1yLkC3Nlg4KM7:TR?= MXnTRW5ITVJ?
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... Click to View More Cell Line Experimental Data

In vivo試験 Treatment with NVP-AUY922 causes a robust antitumor response and inhibits p-Akt and VEGF expression in an HSC-2 xenograft model. [2] In BT474, NVP-AUY922 shows complete loss of ERBB2 and substantial depletion of ERα, in addition to reductions in CDK4 and phospho-ERK1/2. [3]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [3]

Kinase assay NVP-AUY922 is dissolved in DMSO at a concentration of 10 mM. NVP-AUY922 is assessed against HSP90α, HSP90β, GRP94, TRAP-1, HSP72, and topoisomerase II. Profiling against a panel of kinases has been carried out and screening against a panel of additional enzymes and receptors is performed at Cerep.

細胞アッセイ: [1]

細胞株 Human gastric cancer cells NCI-N87
濃度 1 μM
反応時間 3 days
実験の流れ Human gastric cancer cells NCI-N87 (5-7 ×103 in 50 μL/well) are seeded in 96-well plates and incubated at 37 °C for 24 hours, followed by NVP-AUY922 treatment for 1-3 days at 37 °C. After treatment, the cells are assayed by MTT method and analyzed by microplate reader.

動物実験: [3]

動物モデル Female NCr athymic mice bearing WM266.4 human melanoma xenografts
製剤 In DMSO and diluted in sterile saline/Tween 20
投薬量 50 mg/kg
投与方法 Administered via i.v. or i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Luminespib (AUY-922, NVP-AUY922) SDF
分子量 465.54
化学式

C26H31N3O5

CAS No. 747412-49-3
保管 2年-20℃
6月-80℃in solvent
別名 VER-52296
溶解度 (25°C) * In vitro DMSO 93 mg/mL warming (199.76 mM)
エタノール 31 mg/mL (66.58 mM)
<1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

カスタマーフィードバック (3)


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Rating
Source , , Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck
Method Immunostaining
Cell Lines U2OS_exo cells
Concentrations 4 µM
Incubation Time 20 h
Results AUY922 blocked nuclear migration of RelA/p50 induced by TNFα in a dose-dependent manner, consistent with the notion that Hsp90 is required for activation of the NF-κB pathway.

Click to enlarge
Rating
Source J Biol Chem, 2013, 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck
Method Western blot
Cell Lines 293T cells
Concentrations 1 uM
Incubation Time 16 h
Results Treatment of cellswith each of these HSP90 inhibitors (17-AAG, SNX-5422, or NVP-AUY922) caused a significant reduction in TSSK1, -2, -4, and -6 in the cells.

Click to enlarge
Rating
Source 2011, Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck
Method Western blot
Cell Lines BT474 breast cancer cell line
Concentrations 1.0 ± 0.1 nM
Incubation Time 8/24 h
Results Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922.

文献中の引用 (23)

技術サポート&よくある質問(FAQ)

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Related HSP (e.g. HSP90) 阻害剤

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.

  • KNK437

    KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

  • VER155008

    VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

  • FRAX597

    FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.

  • 17-AAG (Tanespimycin)

    17-AAG (Tanespimycin)は、5nMのIC50による強力な熱ショックタンパク質90(Hsp90)阻害剤です。

    Features:Displays very low toxicity toward normal cells.

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090)は独特な triazolone-containing Hsp90阻害剤、 IC50 が4 nM となる.

  • 17-DMAG (Alvespimycin) HCl

    17-DMAG (Alvespimycin) HClは、62nMのIC50による強力なHsp90阻害剤です。

    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    ノーカット二量体Hsp90またはN末端領域Hsp90と結合している間、Geldanamycinは1.2のμMまたは0.78のμMによるKdによる天然既存のHsp90阻害剤です。

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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