MK-2206 2HCl 化学構造
分子量: 480.39

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Quality Control & MSDS

製品説明

  • Compare Akt Inhibitors
    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HClは高度選択的に Akt1, Akt2 and Akt3を抑制して、 IC50がそれぞれ 8 nM, 12 nM と 65 nMになる。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 M2[4VWN6fG:2b4jpZ{BCe3OjeR?= Mm\kN{DPxE1? NUTJRmdNPzJiaB?= NXiyWpNiTE2VTx?= NHPkVGhKdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbh?= MXKyNFU4OTB4OR?=
A431 MlzzT4lv[XOnIFHzd4F6 NGnwdG82KM7:TR?= MVW1JIg> M1PvXmROW09? M3LWXXN2eHC{ZYPz[ZMhfGinIIPp[45idGmwZzDv[kBCc3RiYX7kJGVzcw>? NG\teHAzODV5MUC2PS=>
HepG2 NUTGOXhkS3m2b4TvfIlkKEG|c3H5 NWfZZnFwOTBizszN MV2yOEBp MYrEUXNQ NYPiXWc6W2Wwc3n0bZpmeyC{ZYPpd5RidnRiY3XscJMhfG9idHjlJIN6fG:2b4jpZ{Bm\m[nY4Sgc4Yhe2:{YX\lcolj NVuwfo93OjF{MEW5NlU>
Sk-Hep1 M4rkTGN6fG:2b4jpZ{BCe3OjeR?= M{DIflExKM7:TR?= NHq4WVIzPCCq MUnEUXNQ MUPT[Y5{cXSrenXzJJJme2m|dHHueEBk\WyuczD0c{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDzc5Ji\mWwaXK= MV6yNVIxPTl{NR?=
OCUT1 cells harbored PIK3CA (H1047R+/+) Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[zJO69VQ>? MorSOUBl M1zz[WROW09? NULndFRKUUN3ME2wMlE1KM7:TR?= MlTKNlEzQDl{Nke=
K1 cells harbored PIK3CA (E542K+/+) MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL5XFNJOyEQvF2= MmDIOUBl M{npc2ROW09? NWHuT4xrUUN3ME2wMlUzKM7:TR?= NFO3Z5UzOTJ6OUK2Oy=>
FTC133 cells harbored PTEN (allele deletion and R130+) NEDqbHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXn3e4hLOyEQvF2= NUS0XlN1PSCm NILDTXlFVVOR M2XmSGlEPTB;MD6xPEDPxE1? MlXLNlEzQDl{Nke=
C643 cells harbored HRAS (G13R+/−) NW\4OXZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPqN{DPxE1? NGDPc3M2KGR? Mm\wSG1UVw>? MWHJR|UxRTBwMkeg{txO M37ldlIyOjh7Mk[3
Hth7 cells harbored NRAS (Q61R+/−) NWe5O3NoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF36dFA{KM7:TR?= NF;Kb5A2KGR? NXvxUmloTE2VTx?= MU\JR|UxRTRwNTFOwG0> MXqyNVI5QTJ4Nx?=
TPC1 cells harbored RET/PTC1 rearrangement MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfh[Yw{KM7:TR?= M{TSUVUh\A>? NWDqdIFtTE2VTx?= NH\RfVNKSzVyPUCuOVkh|ryP NWLnNZp{OjF{OEmyOlc>
Hth74 NGCxWGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTRN{DPxE1? NV\PO5dPPSCm M3rK[2ROW09? M4ftbWlEPTB;Mj6xPUDPxE1? NV3vclM{OjF{OEmyOlc>
KAT18 NGrvbmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3v4VVMh|ryP MVS1JIQ> NU\B[|B7TE2VTx?= M3HDV2lEPTB;ND62NkDPxE1? Mm\jNlEzQDl{Nke=
SW1736 MmDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TidlExOCEQvF2= MmK5OUBl M4rVWmROW09? MonqTWM2OD12Nz61OkDPxE1? MU[yNVI5QTJ4Nx?=
WRO NX3UWFVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS1c2EyODByIN88US=> M2HRN|Uh\A>? M4fudmROW09? M{LneWlEPTB-MUCwNEDPxE1? MUGyNVI5QTJ4Nx?=
TAD2 M2LJVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzqNVAxOCEQvF2= M3r6NFUh\A>? MkH0SG1UVw>? NHXueIJKSzVyPkGwNFAh|ryP MorLNlEzQDl{Nke=
LN229 MoH5RZBweHSxc3nzJGF{e2G7 MlHwNE42KM7:TR?= MUm2NEBp NWjvd2FzTE2VTx?= Ml3mRZVodWWwdIOgZZBweHSxZ3XubYMh\W[oZXP0d{Bw\iCpZX\peIlvcWJ? M2LuOFIzODV5OUG0
T98G MV\BdI9xfG:|aYOgRZN{[Xl? NUniZ4d5OC53IN88US=> MlLCOlAhcA>? M2PPcWROW09? M4npNmF2\22nboTzJIFxd3C2b3flcolkKGWoZnXjeJMhd2ZiZ3XmbZRqdmmk NGTjbIozOjB3N{mxOC=>
HC11 MWnGeY5kfGmxbjDBd5NigQ>? NF25elQyOCEQvF2= NF\0OmszPCCq MkDzSG1UVw>? MYHJcohq[mm2czFOtk1k[XOnaX6gZY5lKEGGUmCgd5lvfGinc3nz NH;wTnozOjR{Nk[yNS=>
MOLT-4 NF7vPHhEgXSxdH;4bYMhSXO|YYm= NUPxPGlQOTBizszN MX60PEBp MmjMSG1UVw>? MYrJR|UxRTFwN,MAje69VQ>? MkL2NlI3OTR{NEO=
CEM-R MXLDfZRwfG:6aXOgRZN{[Xl? NGHmOGEyOCEQvF2= NX31OlM3PDhiaB?= M{\0U2ROW09? NID4Z2tKSzVyPUOuN-KBkc7:TR?= MXmyNlYyPDJ2Mx?=
CEM-S MYXDfZRwfG:6aXOgRZN{[Xl? M3\BXlExKM7:TR?= M175S|Q5KGh? MnfySG1UVw>? NXXD[HZbUUN3ME21MlHjiIoQvF2= MkHmNlI3OTR{NEO=
MOLT-4 NFr3dVRHfW6ldHnvckBCe3OjeR?= M{njR|ExKM7:TR?= MoSzNlQhcA>? NVzWZpRWTE2VTx?= M13BTGJtd2OtczDj[YxteyCrbjD0bIUhTzBxR{GgdIhie2Vib3[geIhmKGOnbHygZ5lkdGV? MUGyNlYyPDJ2Mx?=
MOLT-4 NXLMeZFCTnWwY4Tpc44hSXO|YYm= MV:05qCK|ryP M1jYOFQhcA>? MUPEUXNQ NXezd2ExUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|NCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ M1nKWlIzPjF2MkSz
CEM-R NX[yXpllTnWwY4Tpc44hSXO|YYm= M3;G[FTjiIoQvF2= Mo\3OEBp M4O0PWROW09? NWO0bmFvUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|RCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ MYeyNlYyPDJ2Mx?=
CEM-S NX22[FhVTnWwY4Tpc44hSXO|YYm= NF7YXZU16oDLzszN MnTLOEBp NVzDSYNmTE2VTx?= MkXoTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{XBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz NEHUcJAzOjZzNEK0Ny=>
HepG2 cell M3XWcmtqdmG|ZTDBd5NigQ>? NH;qUFQzOCEQvF2= MVGyOEBp M1nTcWROW09? MYHEc5dvemWpdXzheIV{KHSqZTDwbI9{eGixconsZZRqd25ib3[gRWtV NFjxNHgzOzd7N{OxPS=>
HepG2 cell NFnWSlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\DcJdsOzBizszN NHztfXMzPCCq NW[2epB3TE2VTx?= Ml3LTY5pcWKrdIOgZ4VtdCCpcn;3eIg> NWDPboJ3OjN5OUezNVk>
HepG2 cell MV7BdI9xfG:|aYOgRZN{[Xl? NVfQRVJFOjBizszN NV7RToxnOjRiaB?= M1XUPGROW09? M2fCRWlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? NFvY[mkzOzd7N{OxPS=>
GEO NYH0O2F2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Ucmg1PTByIH7N NVfZUFFRPzJiaB?= NWL1dotnTE2VTx?= MlvKTY5pcWKrdIOgZ4VtdCCpcn;3eIg> M3[wRlI1PThzMkOx
CNE-1 M4TL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HvV|ExKM7:TR?= NVjwPWx7QTZiaB?= NFLFRoZFVVOR NEC5NHNKSzVyPUKuPVYh|ryP NILQWoczPTN|NkmyOS=>
CNE-2 NHzmZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLHe|BOOTBizszN MYi5OkBp NY\XOWN7TE2VTx?= Mkj3TWM2OD12LkWzJO69VQ>? MnnRNlU{OzZ7MkW=
HONE-1 NYPwcWw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vQelExKM7:TR?= M2rySlk3KGh? MU\EUXNQ MULJR|UxRTNwM{eg{txO MXiyOVM{Pjl{NR?=
SUNE-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDQb5VUOTBizszN M4Pzflk3KGh? NIOy[2VFVVOR MlnqTWM2OD1yLkWyJO69VQ>? NXPXZVF3OjV|M{[5NlU>
CNE-2 MkXiSpVv[3Srb36gRZN{[Xl? NGjuRlgyOCEQvF2= NH\HZ|U1QCCq NFXieWJFVVOR M3faVGlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhTzF? NXzNdINnOjV|M{[5NlU>
HONE-1 MnTvSpVv[3Srb36gRZN{[Xl? MXWxNEDPxE1? NVjYfYVnPDhiaB?= M3LCSmROW09? M2DEcmlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhTzF? Mom5NlU{OzZ7MkW=
NEC8 M3XRPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzjTWM2OD1yLkC5OlUyKM7:TR?= NFjkcGpUSU6JRWK=
P12-ICHIKAWA NVXPdIRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMUG2NkDPxE1? NHHtSJVUSU6JRWK=
MDA-MB-175-VII MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPQfJlKSzVyPUCuNVM4OzhizszN NWD4VIJOW0GQR1XS
AsPC-1 NY\4O4o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnwZVdrUUN3ME2wMlIzOTJ{IN88US=> NV:3NIVCW0GQR1XS
T47D NGm0TYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\BeGlEPTB;MD6yPFI2KM7:TR?= MXHTRW5ITVJ?
HH NVn3Z5pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7rTWM2OD1yLkOwNlg{KM7:TR?= MWTTRW5ITVJ?
MOLT-16 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moe3TWM2OD1yLkOwN|Ih|ryP MYXTRW5ITVJ?
ES5 NVfndmRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPPTWM2OD1yLkO0OFU2KM7:TR?= MnjqV2FPT0WU
RS4-11 M2rIfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLTSFZKSzVyPUCuN|Q3OSEQvF2= NH23[mZUSU6JRWK=
KARPAS-45 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HZNWlEPTB;MD6zO|MzOSEQvF2= MoK1V2FPT0WU
NCI-H720 NIDaW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HoRmlEPTB;MD6zO|Y4QSEQvF2= MnTYV2FPT0WU
H9 NIjCNVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjETWM2OD1yLkO4PFg{KM7:TR?= NVXNV41yW0GQR1XS
EFM-19 M{n0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3ObFhKSzVyPUCuOFQxOSEQvF2= Mn32V2FPT0WU
SBC-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\jO2lEPTB;MD60OFA{PSEQvF2= NUXoZpRzW0GQR1XS
A4-Fuk MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwNE[4Olgh|ryP MnLvV2FPT0WU
NCI-H1563 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr1VFlKSzVyPUCuOFgyQDlizszN NHLjVGxUSU6JRWK=
HCC1419 NIH1cXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfyTWM2OD1yLkS4PFkzKM7:TR?= MoPhV2FPT0WU
H-EMC-SS NFLibGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X1V2lEPTB;MD60PVk{QSEQvF2= MVXTRW5ITVJ?
BHT-101 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DoNWlEPTB;MD61Nlk3OSEQvF2= NF\TcpFUSU6JRWK=
IGROV-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPLVpJWUUN3ME2wMlU2OjR7IN88US=> NYS4T2x4W0GQR1XS
HGC-27 NIi4O2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j3VGlEPTB;MD61Olc5OyEQvF2= MXXTRW5ITVJ?
MDA-MB-361 MkK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLzWIYxUUN3ME2wMlU4PzZzIN88US=> NIXDVG5USU6JRWK=
KE-37 NIq5d21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vKUGlEPTB;MD61PFI3KM7:TR?= M1i0SXNCVkeHUh?=
HCC70 M{W5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTUR5piUUN3ME2wMlU6QDJ5IN88US=> NVvY[WZuW0GQR1XS
LNCaP-Clone-FGC NEe0flFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;QNZg5UUN3ME2wMlYyODR6IN88US=> M4\X[XNCVkeHUh?=
HAL-01 NGqwZm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fiT2lEPTB;MD62NlE{KM7:TR?= MUDTRW5ITVJ?
HT NWnCPGN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nhdWlEPTB;MD62N|I{QSEQvF2= M{HjdXNCVkeHUh?=
MDA-MB-415 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ruWmlEPTB;MD62N|YzPiEQvF2= MmDEV2FPT0WU
NOS-1 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXre3BKSzVyPUCuOlM4OjNizszN MYnTRW5ITVJ?
DU-145 NXiwbYJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInDcHdKSzVyPUCuOlQ4PDVizszN NEPnSGhUSU6JRWK=
OCUB-M MoruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHsTWM2OD1yLkewPVY3KM7:TR?= NGrQOW5USU6JRWK=
VA-ES-BJ M1;aeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwN{OwNlUh|ryP MVPTRW5ITVJ?
J-RT3-T3-5 M{G5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwN{S0NFMh|ryP MnvYV2FPT0WU
MOLT-4 NFXyWpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITRcVZKSzVyPUCuPFA2QDJizszN M3ezW3NCVkeHUh?=
NB7 NGPyVVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFriNFBKSzVyPUCuPFI1OTFizszN MlLGV2FPT0WU
L-363 NF3temRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjpTWM2OD1yLkizOFQzKM7:TR?= NHPjXZlUSU6JRWK=
NKM-1 MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwOE[yOVMh|ryP Mn62V2FPT0WU
HOP-92 MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwOEeyNlMh|ryP MVnTRW5ITVJ?
OAW-42 M3S0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwOEi3NkDPxE1? NVjqbYJMW0GQR1XS
HuO9 MkTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwOUK3OVEh|ryP MYrTRW5ITVJ?
MFE-280 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C5TmlEPTB;MD65OlQ3PSEQvF2= NW\RVYlYW0GQR1XS
EM-2 MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvwT|NKSzVyPUCuPVc6OzlizszN MV3TRW5ITVJ?
NCI-H520 NXTDbpNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK3TWM2OD1yLkm4OVkzKM7:TR?= MlmyV2FPT0WU
LB2241-RCC NV7CPHpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfmSHRKSzVyPUCuPVk4OzRizszN MnHiV2FPT0WU
SK-NEP-1 NXL2[IY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTFwMUS0PFUh|ryP MlnwV2FPT0WU
LXF-289 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfFTVRKSzVyPUGuNVcyPTZizszN M3\TV3NCVkeHUh?=
EPLC-272H MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PlRmlEPTB;MT6xO|I2PiEQvF2= MlHoV2FPT0WU
COLO-684 NGjCcVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPxTWM2OD1zLkKzO|I2KM7:TR?= NGTOR2lUSU6JRWK=
ES1 NWfCU3lZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH2bJZMUUN3ME2xMlI1ODZ3IN88US=> NHjoO|JUSU6JRWK=
DOHH-2 NEDJbFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTFwMkiyNFMh|ryP NITWOnlUSU6JRWK=
CTB-1 MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDofYdKSzVyPUGuNlg6QSEQvF2= MXjTRW5ITVJ?
G-401 M{\ESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\BTWM2OD1zLkK5O|k2KM7:TR?= NILqUHJUSU6JRWK=
LoVo M4rFV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLkTWM2OD1zLkOyOVM1KM7:TR?= MXXTRW5ITVJ?
Ramos-2G6-4C10 MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImzZllKSzVyPUGuN|M4ODFizszN MnPPV2FPT0WU
MFM-223 NX3CRpMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX1eFRKSzVyPUGuN|Q1PjFizszN NYLKdJJlW0GQR1XS
PA-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHWTWM2OD1zLkO1NlY2KM7:TR?= M2XEbXNCVkeHUh?=
697 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn5UoZKSzVyPUGuN|c3OTZizszN NH7udnZUSU6JRWK=
QIMR-WIL NEnmVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHUR29KSzVyPUGuOFkyOTZizszN NEPRRWJUSU6JRWK=
HOS MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLSTWM2OD1zLkS5OVU5KM7:TR?= NHjMTZNUSU6JRWK=
DMS-273 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\qfmlEPTB;MT61NVk2QSEQvF2= MnK4V2FPT0WU
ME-180 M1H0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\NVlQyUUN3ME2xMlU3QDlzIN88US=> MlXrV2FPT0WU
HCC2218 MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzQTWM2OD1zLk[4NlI2KM7:TR?= NV;5TGhtW0GQR1XS
CAL-54 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPDV5ZKSzVyPUGuO|EzPDJizszN MW\TRW5ITVJ?
OMC-1 M{DrVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m1e2lEPTB;MT63OFY4PyEQvF2= MnnNV2FPT0WU
COR-L105 M3WxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXWWI5KSzVyPUGuO|k4OzdizszN M1LTcnNCVkeHUh?=
BV-173 M1zabGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwOEGwO|Qh|ryP M17CdXNCVkeHUh?=
RKO M2nHRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;2W2lEPTB;MT64O|ExOSEQvF2= MVvTRW5ITVJ?
SNU-387 NGLjO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2POZ2lEPTB;MT64PFQxPiEQvF2= NUjLOoloW0GQR1XS
SW1088 NHfHcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlThTWM2OD1zLkm0OlA3KM7:TR?= MkTsV2FPT0WU
Hs-578-T Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJwMUG0N|Mh|ryP MnHUV2FPT0WU
OC-314 MnP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLrbo83UUN3ME2yMlE2ODh4IN88US=> MYDTRW5ITVJ?
RMG-I MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXHT4dKSzVyPUKuNVY{QThizszN NI\RUVJUSU6JRWK=
NCI-H1395 MofJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLMTWM2OD1{LkG4NFkyKM7:TR?= MXTTRW5ITVJ?
GAMG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK0XGxyUUN3ME2yMlI{QDR3IN88US=> NUTOWWx3W0GQR1XS
LB1047-RCC M4DXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXFTWM2OD1{LkK0N|E4KM7:TR?= NWmwNWRoW0GQR1XS
MN-60 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjUUVZGUUN3ME2yMlI6QTJ|IN88US=> MlG2V2FPT0WU
OAW-28 NFG5cVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfLPJNlUUN3ME2yMlI6QTVzIN88US=> MkTBV2FPT0WU
NCI-H2228 NVPMNZJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;NNJBsUUN3ME2yMlMyPTV{IN88US=> MWfTRW5ITVJ?
ABC-1 NH7YVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2G3bGlEPTB;Mj6zN|I2OyEQvF2= MmrwV2FPT0WU
LS-513 M3;RXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTJwM{O0PFQh|ryP M4POSXNCVkeHUh?=
KS-1 MoHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW0ZXVRUUN3ME2yMlM5OTlzIN88US=> NEDGVHFUSU6JRWK=
NB69 NIHRTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLHbnZKSzVyPUKuN|g6QDNizszN MXvTRW5ITVJ?
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D-423MG M2LMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPkTWM2OD1{LkSxNFQ1KM7:TR?= MoTUV2FPT0WU
EW-18 NI\EZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmewTWM2OD1{LkSxPVM6KM7:TR?= M1P4cnNCVkeHUh?=
YH-13 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu3ZndKSzVyPUKuOFYyPTNizszN M{LINXNCVkeHUh?=
T-24 M3\YbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlz2TWM2OD1{LkS3PFgyKM7:TR?= NHP4PYlUSU6JRWK=
ES8 MoHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH2TWM2OD1{LkS5Nlg4KM7:TR?= MmHmV2FPT0WU
ES3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3CNmNKSzVyPUKuOFk4PTlizszN Mof0V2FPT0WU
RXF393 NWr5XYtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTJwNkC0PFch|ryP Mn;PV2FPT0WU
RPMI-8226 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHCWZBKSzVyPUKuOlI6PTNizszN M1S0VnNCVkeHUh?=
AGS NGK3TVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;PNGlEPTB;Mj63NlE{PyEQvF2= NXv5blF6W0GQR1XS
HCC1395 NFn0WXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnoVZhMUUN3ME2yMlc2OTh5IN88US=> NEPyRm9USU6JRWK=
MV-4-11 Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHTTWM2OD1{Lke1NlY3KM7:TR?= M4\tb3NCVkeHUh?=
A204 NVr2PIhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJwOEO4O|Ih|ryP MlT0V2FPT0WU
MCF7 M3[4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TqbmlEPTB;Mj64OlEyPyEQvF2= Ml;VV2FPT0WU
SNU-423 NYroU|h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[zSXZKSzVyPUKuPFkzPDJizszN MVzTRW5ITVJ?
NCI-H1048 NIfVelBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj0TWM2OD1{Lkm2PFY2KM7:TR?= M4D5VnNCVkeHUh?=
GR-ST MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTWTWM2OD1|LkC0OlEyKM7:TR?= NUjlO4RDW0GQR1XS
EoL-1- MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnBNJdYUUN3ME2zMlA4ODV6IN88US=> M1nqOnNCVkeHUh?=
HuH-7 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;5TWM2OD1|LkC5OFY1KM7:TR?= NWrYbms3W0GQR1XS
OS-RC-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\tTWM2OD1|LkGxNVkh|ryP NEHhUXpUSU6JRWK=
EW-3 NHXNUYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTNwMUm1Nlkh|ryP Mkj4V2FPT0WU
NCI-H747 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTNwMkC2PVQh|ryP M1vjUnNCVkeHUh?=
EW-16 M{\jR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTNwMkG4O|kh|ryP NFnZeYNUSU6JRWK=
DOK NY\hcoZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LEZWlEPTB;Mz6yNlg2QSEQvF2= M1rsbnNCVkeHUh?=
HCC2157 M4rZWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTNwM{ixO|kh|ryP MoPEV2FPT0WU
OVCAR-3 M{m5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHORW1vUUN3ME2zMlQxPzh4IN88US=> MXXTRW5ITVJ?
NCI-H1623 MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoOzTWM2OD1|LkSxNlI1KM7:TR?= NHPuZnlUSU6JRWK=
H4 NFL2ZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPFV5Z{UUN3ME2zMlQ2PjJ4IN88US=> NV2zeGxRW0GQR1XS
SW1710 NFnqdI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTNwNE[2O|gh|ryP NHHXVIxUSU6JRWK=
RT-112 MlLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTNwNUKzPFgh|ryP NVHTfVlOW0GQR1XS
DMS-114 NVvQNXN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEW1V5FKSzVyPUOuOlIzPzhizszN M2ewSXNCVkeHUh?=
AN3-CA M{XmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\sToxKSzVyPUOuOlI1PTZizszN M1TYeXNCVkeHUh?=
KNS-62 NYf3dWdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILGWWNKSzVyPUOuOlM{OzhizszN NHfVUIJUSU6JRWK=
SJRH30 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe3SpdiUUN3ME2zMlY6OTJ{IN88US=> MmfzV2FPT0WU
G-402 NULRcFVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPRS5c3UUN3ME2zMlcxPzFzIN88US=> NUPzWWUxW0GQR1XS
MHH-PREB-1 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTSfoxCUUN3ME2zMlczODN6IN88US=> NFXzbW9USU6JRWK=
P30-OHK MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DK[GlEPTB;Mz64NFk4PiEQvF2= MX7TRW5ITVJ?
RVH-421 MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjhOnVKSzVyPUOuPFE4QDhizszN NF\USZdUSU6JRWK=
LU-134-A M4[4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVSyU4xSUUN3ME2zMlg5PDJ6IN88US=> M3HZVHNCVkeHUh?=
ECC10 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHe2bFJKSzVyPUOuPVM3OjJizszN NUPOe3NFW0GQR1XS
TGW M2LQcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnDe|htUUN3ME20MlAzOzB3IN88US=> NITzSGJUSU6JRWK=
MLMA NXHUeWhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\HdmlEPTB;ND6wNlk3PiEQvF2= NHH3WYtUSU6JRWK=
SCC-25 NIrWflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi2b4FKSzVyPUSuNFY2PjZizszN MUDTRW5ITVJ?
TYK-nu NH\kN3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTRwMEm1N|Qh|ryP NWDoUlUyW0GQR1XS
LAMA-84 NYrqeJdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrENlNsUUN3ME20MlE1OTlzIN88US=> NY[wbZI6W0GQR1XS
Calu-3 NHTtZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTRwMkS0NVYh|ryP NHrkS3pUSU6JRWK=
NCI-H460 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\VNVRKSzVyPUSuNlY1PDNizszN MYjTRW5ITVJ?
EGI-1 NVvKPZpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTRwM{e3O|gh|ryP M3fVfHNCVkeHUh?=
NCI-H292 Mo\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfGTWM2OD12LkO4NVQ3KM7:TR?= NX2yNJpZW0GQR1XS
HCE-T NIG1ZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITtcXBKSzVyPUSuOFE2PzlizszN MV7TRW5ITVJ?
EW-11 NYrPcogzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn5SnBKSzVyPUSuOFE5OzhizszN NHHET3hUSU6JRWK=
ATN-1 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTRwNESzNFQh|ryP M2LyPXNCVkeHUh?=
NB5 MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFL2Z|lKSzVyPUSuOVM3QTdizszN NHPP[GpUSU6JRWK=
KLE NVTYNHY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvZ[oFKSzVyPUSuO|AyQThizszN NIeySpdUSU6JRWK=
CAL-39 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LieGlEPTB;ND63NlE1PiEQvF2= NFP1NJpUSU6JRWK=
TI-73 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRwOEC2NFkh|ryP MX\TRW5ITVJ?
HO-1-N-1 NULWepRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\TPGlEPTB;ND65OFIh|ryP NWryUZh{W0GQR1XS
786-0 NHXhVZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnzW25KSzVyPUSuPVQ3PzNizszN M1f2U3NCVkeHUh?=
SK-N-DZ NFTocmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjxZo1KSzVyPUSuPVYyPDJizszN NXj1T5V7W0GQR1XS
NCI-H446 NVO1XlF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHNNoNMUUN3ME21MlIxODB7IN88US=> M2mzenNCVkeHUh?=
ETK-1 M1HuXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjkTWM2OD13LkKxNVY2KM7:TR?= MUXTRW5ITVJ?
BT-20 NVu5XIN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWj6UG5uUUN3ME21MlIyOzV|IN88US=> M4DxbnNCVkeHUh?=
MEL-HO M{X5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULZbYl[UUN3ME21MlM4OzN4IN88US=> NYf5W4RFW0GQR1XS
CAL-27 MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfkW2NZUUN3ME21MlQ3OzN7IN88US=> MYrTRW5ITVJ?
SW872 Mm\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SxWWlEPTB;NT61PVQzQCEQvF2= Ml;HV2FPT0WU
RPMI-2650 M1;4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXxTWM2OD13Lk[2NVk6KM7:TR?= NYrxSoRGW0GQR1XS
PFSK-1 NUnPemhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLXdJJKSzVyPUWuO|I4OzJizszN MX7TRW5ITVJ?
SF295 M1LlRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\0PVA1UUN3ME21MlgxPjN|IN88US=> NVXOO4NWW0GQR1XS
Becker NXjPUJMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfEUnRKSzVyPUWuPFY1PzJizszN MnPnV2FPT0WU
Saos-2 MoLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTVwOE[1N{DPxE1? NXzaNHJ2W0GQR1XS
SK-OV-3 M{XLRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn3OGhLUUN3ME21Mlk6QDF4IN88US=> NIn5bZFUSU6JRWK=
VMRC-RCZ MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFm5fFVKSzVyPU[uNFg4PzNizszN NEfkc4lUSU6JRWK=
EW-22 MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjGPFRKSzVyPU[uNVk3PDlizszN MYXTRW5ITVJ?
BT-474 NH\Xco5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTZwMkOzJO69VQ>? NGG0SlBUSU6JRWK=
BFTC-909 NYLjOJU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7ScFVQUUN3ME22MlMxOzR3IN88US=> MlHPV2FPT0WU
NB12 NG\3[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXGTWM2OD14LkO5NFcyKM7:TR?= MlfXV2FPT0WU
D-263MG NEn5SHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DpbmlEPTB;Nj60OVE3QSEQvF2= M3TrOHNCVkeHUh?=
SNB75 M2HFO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTZwNkCxOFMh|ryP M1\PbXNCVkeHUh?=
A704 NFjtUoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jJeWlEPTB;Nj62N|A3KM7:TR?= NH7kUWxUSU6JRWK=
NCI-H1693 NHTETmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\PTWM2OD14Lk[zOlA1KM7:TR?= NWC1fId4W0GQR1XS
LN-405 M{f3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTZwN{m2O|Ih|ryP NXzlO|dEW0GQR1XS
CHL-1 MoLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTZwOECwO|kh|ryP M2Gw[HNCVkeHUh?=
A498 MonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3VUIpbUUN3ME22MlgyQTZzIN88US=> MnPvV2FPT0WU
TE-12 NGDnZnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfZfGxXUUN3ME22Mlg{QDF5IN88US=> NEDCd5pUSU6JRWK=
TE-6 MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILVeGxKSzVyPU[uPVMxOzhizszN MXrTRW5ITVJ?
AU565 NWniUGxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnmOVVKSzVyPU[uPVY6PTdizszN MUDTRW5ITVJ?
RD MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj3XHNbUUN3ME22Mlk5Ojh2IN88US=> NWfHZYhKW0GQR1XS
SW1463 M2rERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTdwMUGxOlgh|ryP NVfkWJdbW0GQR1XS
LU-99A MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DSWmlEPTB;Nz6xOFMzOiEQvF2= MVnTRW5ITVJ?
NCI-H28 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn5TmRKSzVyPUeuNlkzPCEQvF2= M1fIbnNCVkeHUh?=
MC-IXC NFjycIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3JdGZKSzVyPUeuOFg2PzZizszN NH3CbZhUSU6JRWK=
GP5d MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\FbpNKSzVyPUeuOFg4PjRizszN MVfTRW5ITVJ?
GB-1 Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TFOWlEPTB;Nz61OFgxPCEQvF2= MWHTRW5ITVJ?
CAL-33 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTdwNk[yN|Mh|ryP NEHEbZFUSU6JRWK=
MSTO-211H MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv2fpVoUUN3ME23MlY4OzN4IN88US=> MYnTRW5ITVJ?
TE-5 NGfRflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jNZmlEPTB;Nz63PVM{PCEQvF2= NWPybmRKW0GQR1XS
D-566MG MknNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H0WGlEPTB;OD6wOFQzQSEQvF2= MlTXV2FPT0WU
JVM-3 NHzPZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\QW5BKSzVyPUiuNVUzPjhizszN MUXTRW5ITVJ?
T98G M17TUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm5fIhKSzVyPUiuNVgxPjdizszN MYnTRW5ITVJ?
HCC1954 NUfsTIZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MneyTWM2OD16LkS1NVA1KM7:TR?= M{jOVHNCVkeHUh?=
SF126 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rx[2lEPTB;OD60OVk{PiEQvF2= MWrTRW5ITVJ?
LB996-RCC NIrlXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\iPIhXUUN3ME24MlU{OjV5IN88US=> M2DvTXNCVkeHUh?=
SKG-IIIa MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDXRVlKSzVyPUiuOlMxPjlizszN NFLVellUSU6JRWK=
NCI-SNU-1 MkP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vwVmlEPTB;OD62OFY1OyEQvF2= M1HU[nNCVkeHUh?=
LB771-HNC MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M173bWlEPTB;OD62OFY6PiEQvF2= NWriOVBtW0GQR1XS
SCC-4 M2DUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjFc2pvUUN3ME24MlY5OjF7IN88US=> NVXsPYl4W0GQR1XS
CAMA-1 M1j2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRThwN{exOFYh|ryP NI\6O|BUSU6JRWK=
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NB10 NEPveYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvaOJBKSzVyPUmuNFIzOjRizszN M3jFfnNCVkeHUh?=
8505C M{D5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTlwMESyN|Ih|ryP NVXUVI5nW0GQR1XS
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HN M3[0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnvXG01UUN3ME25MlE3PjJ6IN88US=> MVLTRW5ITVJ?
DSH1 NYSxdYk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXuTWM2OD17LkKwPFch|ryP NW\Kb2l{W0GQR1XS
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LS-123 MoHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvNTWM2OD17LkOxO|YyKM7:TR?= Mm\jV2FPT0WU
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U251 NFLSNpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTlwNkW1OFQh|ryP MV3TRW5ITVJ?
A431 NXnLOW5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zmcGlEPTB;OT64NFI{QCEQvF2= NEjIVGdUSU6JRWK=
5637 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTlwOES5PFQh|ryP NEG0Wm5USU6JRWK=
MDA-MB-157 MlvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfmSIQxUUN3ME25MlkzQDd6IN88US=> NEjTXlVUSU6JRWK=
A101D MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofZTWM2OD17Lkm5PVc1KM7:TR?= MoXkV2FPT0WU
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LAN-6 M1rabGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfGbFdVUUN3ME2xNE4zOTZ2IN88US=> MWXTRW5ITVJ?
OVCAR-5 Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TmbmlEPTB;MUCuNlQ{OyEQvF2= MWfTRW5ITVJ?
A549 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFyLkO5O|Mh|ryP M{j0dHNCVkeHUh?=
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A388 M4rSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrRZVJKSzVyPUGxMlM5QTdizszN M3raOHNCVkeHUh?=
DEL MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1POOGlEPTB;MUGuOFI1KM7:TR?= M4LGcHNCVkeHUh?=
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MEG-01 M{DhVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTFzLke1NFkh|ryP NEDpboVUSU6JRWK=
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GCT M4rZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHi0V4lKSzVyPUGxMlgzOjhizszN NHvNSo1USU6JRWK=
D-247MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki3TWM2OD1zMT65OlY{KM7:TR?= Ml;NV2FPT0WU
CFPAC-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFzLkm3PFIh|ryP NV3yXZRiW0GQR1XS
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CAL-51 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTF{LkC3NVYh|ryP Ml7UV2FPT0WU
BB49-HNC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fzdmlEPTB;MUKuNVE4PyEQvF2= NXLGZXFRW0GQR1XS
RPMI-7951 M4jSRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\hR5ZKSzVyPUGyMlE5PTRizszN NH3P[GlUSU6JRWK=
RH-1 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnQXY9KSzVyPUGyMlIyQDRizszN NHezRpRUSU6JRWK=
BCPAP MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTF{LkS3OFkh|ryP NXzxPYg{W0GQR1XS
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KNS-81-FD M1P6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf3ZWxKSzVyPUGyMlU5PjlizszN M1;S[XNCVkeHUh?=
KYSE-140 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPZXVdKSzVyPUGyMlg2QTVizszN Mny2V2FPT0WU
Ca-Ski MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTF{LkmwOFEh|ryP NV3xXWRTW0GQR1XS
TGBC1TKB M3vJ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rwTGlEPTB;MUKuPVEyPSEQvF2= NXH0Xo1uW0GQR1XS
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CTV-1 M1K5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTF|LkO0OUDPxE1? MX3TRW5ITVJ?
WM-115 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PxXWlEPTB;MUOuOlQ5OyEQvF2= MWHTRW5ITVJ?
CHP-212 MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTnTWM2OD1zMz65O|M6KM7:TR?= M1HyfnNCVkeHUh?=
SCC-15 MnLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M324fGlEPTB;MUOuPVc4PSEQvF2= Ml60V2FPT0WU
BPH-1 NIXWU45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHqTWM2OD1zND6xOlY1KM7:TR?= M2LObXNCVkeHUh?=
SW780 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonYTWM2OD1zND61NFI2KM7:TR?= NWLXXG5bW0GQR1XS
NCI-H2291 MlnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTF2LkW4O|gh|ryP M1PY[HNCVkeHUh?=
JEG-3 MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn72TWM2OD1zND62N|I3KM7:TR?= NHnEcFBUSU6JRWK=
CAL-120 NFXuU5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTF2LkewNlch|ryP NGPvSplUSU6JRWK=
NCI-H23 NVPRSYRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF2Lke5PVch|ryP NWXCTmZpW0GQR1XS
MS-1 MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m0NGlEPTB;MUSuPVYyOSEQvF2= MWfTRW5ITVJ?
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D-283MED NGLVSXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDMTWM2OD1zNT6wNVEyKM7:TR?= MoDNV2FPT0WU
OE19 M{PBOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHntUJJKSzVyPUG1MlE2PDFizszN MnrDV2FPT0WU
CAS-1 M2KxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1SxbmlEPTB;MUWuOFE5PCEQvF2= MWDTRW5ITVJ?
NCI-H727 NYrP[nNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrGVoVzUUN3ME2xOU41OjJzIN88US=> NYHrUItGW0GQR1XS
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MDA-MB-453 NW\tU4dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[5TWM2OD1zNj6xOlQzKM7:TR?= Mn3xV2FPT0WU
HuP-T3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojaTWM2OD1zNj62N|c{KM7:TR?= M33CVXNCVkeHUh?=
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Detroit562 M2flXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHUTWM2OD1zNj63N|E5KM7:TR?= MkDTV2FPT0WU
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SK-MES-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P1RmlEPTB;MU[uPFQyQSEQvF2= NH:2NodUSU6JRWK=
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LOXIMVI NWnzR5R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjUTWM2OD1zNz6wO|A4KM7:TR?= NU\B[ZFiW0GQR1XS
SW1783 NGjTeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF5LkGyPEDPxE1? MUnTRW5ITVJ?
NH-12 NVnWTGtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fjV2lEPTB;MUeuN|MxOyEQvF2= M4LwZ3NCVkeHUh?=
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KG-1 NYjBPIpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTF5Lk[5N|ch|ryP NVL5[Gg1W0GQR1XS
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MHH-NB-11 M2i2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\acmlEPTB;MUeuPVY4OyEQvF2= MXLTRW5ITVJ?
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639-V M1ywVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjXTWM2OD1zOD6zN|U1KM7:TR?= MVzTRW5ITVJ?
C32 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojnTWM2OD1zOD60O|I4KM7:TR?= MUDTRW5ITVJ?
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A253 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTF6LkeyPFYh|ryP MXrTRW5ITVJ?
NCI-N87 NFPZc21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn3OWlKSzVyPUG4MlkxODhizszN MX;TRW5ITVJ?
8-MG-BA MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPwS21HUUN3ME2xPU4xPjR4IN88US=> NXnObY91W0GQR1XS
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KYSE-270 Mm\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHGRZdKSzVyPUKwMlAzOTdizszN Mm[wV2FPT0WU
HL-60 NGf6W2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\kTWM2OD1{MD6wPVQyKM7:TR?= NVfoVG9wW0GQR1XS
Mo-T Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSxOJR5UUN3ME2yNE4yPjZ3IN88US=> NE\0Zo5USU6JRWK=
NCI-H1355 NXjyN3hNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoW3TWM2OD1{MD6zN|c1KM7:TR?= M3PHWHNCVkeHUh?=
HT-1080 NXzBOnVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\w[G9DUUN3ME2yNE42PDl5IN88US=> MoK4V2FPT0WU
MIA-PaCa-2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nWPGlEPTB;MkCuOlg5OyEQvF2= MYHTRW5ITVJ?
NCI-H441 NFvheIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHMdYg5UUN3ME2yNE44Ozd7IN88US=> MknwV2FPT0WU
LCLC-97TM1 NYLIfZhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\wc5FKSzVyPUKwMlgyOzRizszN NFjV[XhUSU6JRWK=
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LK-2 NXPGUWdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTwTWM2OD1{MT61PVU{KM7:TR?= NYn4dJdxW0GQR1XS
CW-2 M2TUbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LKVmlEPTB;MkGuOlA3QSEQvF2= NE[wS4lUSU6JRWK=
KYSE-510 M2TPVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;jWmlEPTB;MkGuOlA6PSEQvF2= MVLTRW5ITVJ?
CGTH-W-1 MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPFTWM2OD1{MT63NVY3KM7:TR?= MXLTRW5ITVJ?
NCI-H661 NHS5OpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJ{LkCzOEDPxE1? NHfmNIxUSU6JRWK=
KU-19-19 NUHxe5ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nhUWlEPTB;MkKuNVY6PyEQvF2= NYDXboF1W0GQR1XS
NCI-H2122 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jCOWlEPTB;MkKuNlQ{OiEQvF2= NILNXpdUSU6JRWK=
NCI-H526 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLWeI5GUUN3ME2yNk4{QDl3IN88US=> MVXTRW5ITVJ?
NCI-H1650 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJ{Lke2OEDPxE1? M1vVc3NCVkeHUh?=
AM-38 M3S1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SzRmlEPTB;MkKuPFY5QSEQvF2= NX70RW4{W0GQR1XS
NCI-H2405 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3VU3BoUUN3ME2yN{4zPTN|IN88US=> M1PpNXNCVkeHUh?=
M14 M{jrUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTJ|LkSwPFgh|ryP MUTTRW5ITVJ?
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IST-MEL1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j6SGlEPTB;OE[uPFg4OiEQvF2= MmnZV2FPT0WU
KP-N-YS NUnhOJY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zMNWlEPTB;OEmuPVAzQCEQvF2= NVvjXVg4W0GQR1XS
KYSE-410 MmjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3yNnpKSzVyPUmxMlQxPDJizszN MkTBV2FPT0WU
TE-10 M4\wOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTlzLkW2NVEh|ryP NFmyOWNUSU6JRWK=
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COLO-792 Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDUTWM2OD17NT6yOVY1KM7:TR?= MULTRW5ITVJ?
SCH MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LZNWlEPTB;OU[uN|g4PyEQvF2= NWflcW82W0GQR1XS
NCI-H1792 NXHieFRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X6eGlEPTB;OU[uPFk6OiEQvF2= MWDTRW5ITVJ?
NCI-H2029 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXSNnQyUUN3ME25Ok46PTZ4IN88US=> MoTXV2FPT0WU
SW684 NU\hNpRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;kV2lEPTB;OUiuOlY2PCEQvF2= NIDBe|RUSU6JRWK=
NCI-H209 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;ZfmlEPTB;MUCwMlEzOSEQvF2= NWm2V|Z{W0GQR1XS
HLE NETDdmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTFyNT6yPFIh|ryP MYfTRW5ITVJ?
GOTO NHixWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj2dIFKSzVyPUGwO{44PzdizszN NFnFTVBUSU6JRWK=
NCI-H1793 MmS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFyOT6yPEDPxE1? NHn5d3ZUSU6JRWK=
D-392MG NGjHd4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rYS2lEPTB;MUG3MlM6QCEQvF2= M1vlZnNCVkeHUh?=
SW1990 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPwTWM2OD1zMkCuPVUyKM7:TR?= NYLSZXJiW0GQR1XS
ML-2 MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[4b3hKSzVyPUGyNU43PzZizszN NUPrXJV6W0GQR1XS
NCI-H2452 MkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInBPZpKSzVyPUGyNk4zOSEQvF2= NV7RbJJLW0GQR1XS
SK-MEL-30 M1:5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\GWmZKSzVyPUGyN{4zPDRizszN MnL6V2FPT0WU
SN12C NFyyZmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe5WllOUUN3ME2xNlQvOTd4IN88US=> NXv3cIVMW0GQR1XS
NCI-H1770 Mli3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTF{NT61NVQh|ryP MWPTRW5ITVJ?
SF268 MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnncXliUUN3ME2xNlYvOTV6IN88US=> MYnTRW5ITVJ?
BALL-1 NIDRfIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XvOGlEPTB;MUK2MlI{KM7:TR?= MWjTRW5ITVJ?
COLO-679 NUXRb4gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfBTWM2OD1zMk[uO|U{KM7:TR?= NFu1SYhUSU6JRWK=
A2780 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;Pc2lEPTB;MUK4Mlk5QCEQvF2= MlfaV2FPT0WU
NCI-H1651 NETL[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF|MT6yOFMh|ryP MVPTRW5ITVJ?
NCI-H2087 MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULmNHNmUUN3ME2xN|EvPDh|IN88US=> MX7TRW5ITVJ?
U-87-MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qwWWlEPTB;MUOzMlYxPCEQvF2= Mnj4V2FPT0WU
LB2518-MEL NHi2SWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK3TWM2OD1zM{WuPVk{KM7:TR?= NXTBT2E1W0GQR1XS
HCT-116 NHLNdGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDJOVBKSzVyPUGzO{4zOTdizszN M4XxbXNCVkeHUh?=
Ca9-22 M4n6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjJVZNKSzVyPUGzPU45OzNizszN NIS5TVZUSU6JRWK=
COR-L88 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqzTWM2OD1zNEKuNVQh|ryP MVXTRW5ITVJ?
CP50-MEL-B MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HufGlEPTB;MUS0MlUxOSEQvF2= NXzDNodDW0GQR1XS
OVCAR-8 MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfkbpVOUUN3ME2xOFUvPjN4IN88US=> MWHTRW5ITVJ?
SK-MEL-3 NFvLcZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjBbnRrUUN3ME2xOFcvQDd6IN88US=> NIHZXlNUSU6JRWK=
GT3TKB M4iwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLETWM2OD1zNEmuPVI5KM7:TR?= NVTIOZhXW0GQR1XS
KYSE-450 M1fOTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3EbllKSzVyPUG1NU42OzlizszN NVHz[FA1W0GQR1XS
CAPAN-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTF3Mz6wOlQh|ryP NH;JOVJUSU6JRWK=
BEN NGXvdJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTF3Mz65Nlgh|ryP NWXtTHJIW0GQR1XS
NCI-H1304 M2e1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7qVZVKSzVyPUG1OE43QTRizszN M4PFeHNCVkeHUh?=
KU812 NHq5bYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTF3OD62O|Qh|ryP NX3OUWFWW0GQR1XS
Capan-2 M1HyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\PeG1KSzVyPUG2NE42PTNizszN M4L2NnNCVkeHUh?=
A673 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofpTWM2OD1zNkGuO|A2KM7:TR?= M1rVPXNCVkeHUh?=
SAS M32yXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITYNJFKSzVyPUG2Nk43PzhizszN NYHKUpNIW0GQR1XS
NY M4DEXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLydVVHUUN3ME2xOlUvOzF2IN88US=> NFrJVpZUSU6JRWK=
HCE-4 NWPX[odiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zGVWlEPTB;MU[2Mlg1PSEQvF2= NUDjWVIxW0GQR1XS
MDA-MB-231 MkPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF5Nz61NFMh|ryP M{XkdnNCVkeHUh?=
no-10 NGXKSIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPJV2ZKSzVyPUG3PE4yOzRizszN NIjjSINUSU6JRWK=
MZ7-mel MnzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PmXGlEPTB;MUe4MlQ3PyEQvF2= MXPTRW5ITVJ?
NCI-H82 MojmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqwTWM2OD1zOECuNVY2KM7:TR?= NF7oR3NUSU6JRWK=
CAL-72 MoT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF6NT6wOVQh|ryP NF25fGZUSU6JRWK=
NCI-SNU-5 M3PjV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW5TWM2OD1zOE[uPFQh|ryP MV\TRW5ITVJ?
OVCAR-4 M2OyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\UTWt7UUN3ME2xPFgvOzN|IN88US=> NYfiV5RuW0GQR1XS
SCC-9 NVf3dIdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTF7MTFOwG0> NIfQPG1USU6JRWK=
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HT-29 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYWyZZdUUUN3ME2yNFEvOjF{IN88US=> M{jQZXNCVkeHUh?=
COLO-678 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W4Z2lEPTB;MkCxMlQ2KM7:TR?= NF;zdFZUSU6JRWK=
NCI-H650 NEjucYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPXSo5EUUN3ME2yNFIvOTB|IN88US=> NWjK[phuW0GQR1XS
HuCCT1 NWXpUVlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoSyTWM2OD1{MESuNlA5KM7:TR?= MWPTRW5ITVJ?
SW1116 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHZTWM2OD1{MEeuNFc4KM7:TR?= NXLNOJNbW0GQR1XS
DBTRG-05MG M1HXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPDd|FKSzVyPUKwO{46ODlizszN NHTzU4FUSU6JRWK=
SW982 MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DuXWlEPTB;MkC3Mlk1QCEQvF2= NWXaeYV6W0GQR1XS
RCM-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn31TWM2OD1{MUSuO|YzKM7:TR?= NWK3OZpPW0GQR1XS
COLO-320-HSR NEXCWlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJzNj6xNlUh|ryP MX3TRW5ITVJ?
KNS-42 NFXjN2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjBOlhoUUN3ME2yNVYvPTd2IN88US=> Mn;lV2FPT0WU
C2BBe1 MkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm0TWM2OD1{M{GuPVA2KM7:TR?= M3\vWnNCVkeHUh?=
CCRF-CEM NH[wS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L0VmlEPTB;MkSzMlc6PSEQvF2= NGTrfY9USU6JRWK=
SH-4 Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\JOGlEPTB;MkS2MlA6KM7:TR?= MXLTRW5ITVJ?
LS-1034 NUjoVoJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\TTWM2OD1{NE[uNlY3KM7:TR?= NFHuZ2ZUSU6JRWK=
NCI-H2347 MoLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJ2Nz63NVMh|ryP MX;TRW5ITVJ?
RPMI-8866 MmDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n2ZmlEPTB;MkS5MlI4KM7:TR?= NW[1e|NtW0GQR1XS
GAK NFfiOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXoOJFKSzVyPUK1N{4xODJizszN NYmwdXRDW0GQR1XS
NB6 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jzOmlEPTB;MkewMlEh|ryP M3nOWXNCVkeHUh?=
COLO-680N MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zUPWlEPTB;MkeyMlUzPyEQvF2= NHz1S4JUSU6JRWK=
RERF-LC-MS NVjvb2FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV74[lQ1UUN3ME2yO|YvODB5IN88US=> MnnRV2FPT0WU
TGBC11TKB NUf2b2FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHESXhKSzVyPUK3PE4yPzhizszN NF7IW29USU6JRWK=
C8166 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ5OD61NFYh|ryP MknlV2FPT0WU
HDLM-2 NICxcWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojXTWM2OD1{OUSuOFA6KM7:TR?= M3\mPXNCVkeHUh?=
IGR-1 NYXqUJV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGruZnVKSzVyPUK5OU43PTlizszN NHn6VpZUSU6JRWK=
FADU MkXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDQNIlOUUN3ME2yPVcvPTFizszN NH2wb5hUSU6JRWK=
L-428 MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXu[GlKUUN3ME2yPVcvPjF4IN88US=> MnfkV2FPT0WU
LU-65 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C1WmlEPTB;M{C0MlMzKM7:TR?= Mmf5V2FPT0WU
HEL NW\5dmZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjxTnBKSzVyPUOwPU46QDNizszN M{THZXNCVkeHUh?=
NCI-H810 NUf6ZXo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTNzMD61O{DPxE1? NX;4T5FDW0GQR1XS
C3A NUO5PYl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4T6fGlEPTB;M{GxMlgxOiEQvF2= NFLueodUSU6JRWK=
NCI-H630 NW\TWnltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILXT2hKSzVyPUOzNk4zQTRizszN NF;6VJpUSU6JRWK=
KP-N-YN NWWyZZhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTN2MT6xNlMh|ryP NF3x[Y9USU6JRWK=
MOLT-13 NXHQV|dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTN2Mj6zNlYh|ryP MXvTRW5ITVJ?
NCI-H1993 MlrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnRc|dKSzVyPUO0Nk4{PjVizszN M1Hv[HNCVkeHUh?=
BE-13 NIjwNoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoC0TWM2OD1|NESuNVY4KM7:TR?= MUHTRW5ITVJ?
IST-SL1 M2\KR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3uTWM2OD1|NEeuOFAyKM7:TR?= NWq5dlg2W0GQR1XS
TE-9 MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTN4Mz61PFkh|ryP M4D5WXNCVkeHUh?=
LU-135 NXPufYlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjmeHdKSzVyPUO2O{4xOzVizszN Mlj0V2FPT0WU
T84 NHrrS4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[3VYxIUUN3ME2zO|QvPzF{IN88US=> NVTlcmFiW0GQR1XS
K-562 NEPGXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTN6Mz6zOkDPxE1? M37WZnNCVkeHUh?=
SBC-5 NFfBS|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTLPYxKSzVyPUO4Ok46QDVizszN MmHHV2FPT0WU
NB17 NUDoNGdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTN7Mj61PVYh|ryP Ml\5V2FPT0WU
NCI-H2052 Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\CUWhKSzVyPUO5PE41PzJizszN MmjaV2FPT0WU
HCC38 Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7rNZFZUUN3ME20NFEvPTl|IN88US=> MV3TRW5ITVJ?
NCI-H69 NYLUe5FmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jEb2lEPTB;NESxMlA5OyEQvF2= NGjwO2lUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

カスタマーフィードバック (18)


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Source , , Cell, 2015, 160(1-2): 161-76 . MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines Ser78 cells
Concentrations 5 µM
Incubation Time 1 h
Results Two selective AKT inhibitors MK-2206 and GDC-0068, both significantly reduced MKK4 phosphorylation on Ser78 in axons after injury.

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Source Cancer Cell, 2013, 24, 766-76. MK-2206 2HCl purchased from Selleck
Method analysis of luciferase activity
Cell Lines immunodeficient NOG mice
Concentrations 10 mg kg-1
Incubation Time 3 days
Results In this experiment, animalstreated with dexamethasone or MK2206 showed progressivetumor growth similar to that observed in vehicle-treated controls,while mice treated with MK2206 plus dexamethasone had significant antitumor responses.

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Source Cancer Discov, 2012, 2, 934-47. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines PC9GR4/WZR10 cells
Concentrations 1 uM
Incubation Time 72 h
Results The addition of a dual PI3K and MTOR inhibitor, PI103, or the AKT inhibitor MK-2206, did reduce the expression of pAKT neither in GR4 cells nor WZR10 cells.

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Source J Exp Med, 2014, 211(9), 1741-58. MK-2206 2HCl purchased from Selleck
Method 3D migration model
Cell Lines WT or Rap1b-/- neutrophil
Concentrations 2 uM
Incubation Time
Results MK-2206 treatment completely reversed elevated TEM across mouse endothelial cells of Rap1b-/- neutrophils to WT levels (A). It reduced ECM degradation of Rap1b -/- neutrophils, and inhibited their multiple protrusions (B and C). Furthermore, almost all Rap1b -/- cells treated with MK-2206 were found at the endothelial cell junctions (D).

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Source Nat Commun, 2015, 6:6943. MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines HUVECs
Concentrations 1 uM
Incubation Time 8 h
Results Because YAP is also a known substrate of Akt21, we examined whether blockade of the Akt pathway affects YAP phosphorylation. Both Ly294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and MK-2206, an allosteric inhibitor of Akt, suppressed cell contact-mediated YAP phosphorylation.

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Source Leukemia, 2015, 29(1), 169-76. MK-2206 2HCl purchased from Selleck
Method Immunoblotting
Cell Lines CXCR4S338X-expressing BCWM.1 cells
Concentrations 0.5 uM
Incubation Time 6 h
Results As AKT and ERK, but not BTK, show continued SDF-1a-triggered activation in CXCR4S338X-expressing WM cells treated with ibrutinib, we next sought to clarify if AKT and ERK contributed to the enhanced survival of these cells. It therefore treated SDF-1acultured CXCR4S338X BCWM.1 cells with either AKT- (MK-2206 and AZD-5363) or MEK- (AS-703026, AZD-6244 and UO126) specific inhibitors with and without ibrutinib (0.5 uM) for 6 h so as to clarify the contribution of AKT and ERK to ibrutinib resistance. The inhibitory activity of MK-2206, as well as AS-703026, AZD-6244 and UO126 was confirmed by western blot analysis for pAKT (S473) and pERK (T202/Y204), respectively.

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Source Cancer Res, 2013, 73, 2189-98. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines SKNAS/SJNB8/IMR32/GIMEN/SHEP2/KCNR/NGP/LAN1/LAN5/TR14/UHGNP cell lines
Concentrations 8 μM
Incubation Time 48 h
Results The 8 μM MK-2206 treatments resulted in effective pathway inhibition in all cell lines as shown by western blot for phosphoryl ated FOXO3a and PRAS40 as well as AKT serine 473 phosphorylation.

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Source Oncotarget, 2011, 2, 1109-26. MK-2206 2HCl purchased from Selleck
Method Western blot/ Wst-1 assay
Cell Lines ATC/ FTC cell lines
Concentrations 500 nM
Incubation Time 1 h/72 h
Results One-hour treatment with the AKT inhibitor MK-2206 (0.5 μM) or with the MEK inhibitor U0126 (10 μM) effectively abolished AKT and ERK1/2 phosphorylation in all cell lines.

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Source Sci Signal, 2011, 4, rs9. MK-2206 2HCl purchased from Selleck
Method ELISA
Cell Lines HeLa cells
Concentrations 1 μM
Incubation Time
Results Treatment of infected cells with kinase inhibitors directed at Akt (MK-2206), MEK(PD 98059), PKC(CEC), or Pim family kinases identified a dominant role for Pim family kinases in the release of IL-8 from Salmonella-infected epithelial cells.

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Source FASEB J, 2013, 27, 1644-56. MK-2206 2HCl purchased from Selleck
Method Clonogenic growth assay
Cell Lines U2OS cells
Concentrations 1 μM
Incubation Time 9 d
Results Specific inhibition of PKB activity using MK-2206 or triciribine also significantly reduced cell growth, although to a lesser extent compared to PI-103, suggesting that both the PKB and mTOR pathways are important for anchorage-dependent growth.

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Source Gynecol Oncol, 2011, 123, 13-8. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines ovarian cancer cell lines
Concentrations 1-6 μM
Incubation Time 1 h/72 h
Results Activation of pAKT by IGF-1 in the low-grade cell line HOC-7 was blocked by the AKT inhibitor MK-2206.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Confocal microscopy
Cell Lines platelets
Concentrations 1μM
Incubation Time
Results Upon treatment with increasing concentrations of AEA from 0.1 to 10 mM (Fig. B–D) platelets were fully fluorescently marked as compared to control (Fig. A) and the increase in DAF 2 fluorescence intensity appears to be dose-dependent. In agreement with data shown in Figure 4, SR1(Fig. E) and MK2206 (Fig. F) abolished fluorescence intensity induced by AEA, while LY294002 (Fig. 5G) was less potent.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines platelets
Concentrations 1 μM
Incubation Time
Results eNOSser1177 phosphorylation was greatly reduced by LY294002 and cancelled by MK2206 but it was not modified by platelet pretreatment with EGTA or BAPTA/AM.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Nitriter+Nitrate(NOX) measurement, cGMP detection
Cell Lines platelets
Concentrations 1 μM
Incubation Time 1 min
Results As shown in Figure 4 SR1 significantly reduced both NOx and cGMP formation, while SR2 failed to affect these parameters.

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Source Radiat Oncol, 2009, 4, 43. MK-2206 2HCl purchased from Selleck
Method Western blot, clonogenic survival assay
Cell Lines U87MG cells
Concentrations 1 μM
Incubation Time 1 h
Results Akt inhibitor MK-2206 showed similar effect. MK-2206 is a potent allosteric Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3 respectively. U87MG cells were preincubated with 1 μM MK-2206 for 1 hr, followed by irradiation at 0 - 9 Gy. As shown in Fig C, MK-2206 treatment abolished IR-induced Akt phosphorylation. Moreover, treatment with MK-2206 also increased the radiosensitivity of U87MGcells (Fig. D)

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Source Dr. Zhang of Tianjin Medical University. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines Breast cancer cells
Concentrations 0-10 nM
Incubation Time 3 h
Results Breast cancer cells were serum starved for 24 h, pretreated with the indicated concentrations of MK-2206 for 3 h, and then treated with 100ng/ml EGF for 15 min.

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Source Biochim Biophys Acta, 2012, 1823, 987-96. MK-2206 2HCl purchased from Selleck
Method Immunofluorescence
Cell Lines HC11 cells
Concentrations 10 µM
Incubation Time 1 h
Results whole ADRP levels, estimated by Western blot , decreased only in the presence of MK -2206 and LY294002. In most cases, ADRP decorated the surface of small lipid droplets and appeared as little patches on large cytoplasmic lipid droplets. With the exception of SP600125, which induced a strong ADRP coating of almost all cytoplasmic lipid droplets (although this inhibitor did not increase ADRP synthesis), variation in the distribution of ADRP at the surface of lipid droplet was difficult to estimate, notably because the signal was faint and uneven.

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Source MK-2206 2HCl purchased from Selleck
Method Western blot analysis
Cell Lines MCF-7 cells
Concentrations 0 nM/100 nM/250 nM/1000 nM
Incubation Time 24 h
Results The effect of MK-2206 on the serine 473 phosphorylation mark of AKT 1 was uneven and did not correlate with inhibition of AKT activity, but the AKT1 mutant cells maintained higher levels of AKT1 serine 473 phosphorylation with increasing concentrations of MK-2206. Of note, MK-2206 completely inhibited AKT2 activation at 100 nM, a concentration where PIK3CA E545K mutant, but not AKT1 mutant cells were already strongly growth inhibited. MK-2206 treatment up to 1 μM did not have strong effects on other protein biomarkers such as ribosomal protein S6, ev en though growth was suppressed by approximately 80% in MCF-7 cells at this concentration.

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