MK-2206 2HCl 化学構造
分子量: 480.39

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Quality Control & MSDS

製品説明

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    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HClは高度選択的に Akt1, Akt2 and Akt3を抑制して、 IC50がそれぞれ 8 nM, 12 nM と 65 nMになる。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 NWXaWYNyS3m2b4TvfIlkKEG|c3H5 MlvzN{DPxE1? NVTxUXVRPzJiaB?= MlrhSG1UVw>? MULJcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdg>? NFLGXGEzODV5MUC2PS=>
A431 M3qyTmtqdmG|ZTDBd5NigQ>? MVu1JO69VQ>? NUPuWXRpPSCq NWPVU21zTE2VTx?= NFHTSI1UfXCycnXzd4V{KHSqZTDzbYdv[Wyrbnegc4YhSWu2IHHu[EBGemt? M1zNd|IxPTdzME[5
HepG2 M2XXSGN6fG:2b4jpZ{BCe3OjeR?= MlnHNVAh|ryP NHSyc|gzPCCq MkPGSG1UVw>? M4PRRnNmdnOrdHn6[ZMhemW|aYP0ZY51KGOnbHzzJJRwKHSqZTDjfZRwfG:6aXOg[YZn\WO2IH;mJJNwemGoZX7pZi=> MVOyNVIxPTl{NR?=
Sk-Hep1 NWOxSZpXS3m2b4TvfIlkKEG|c3H5 NF\4e48yOCEQvF2= NVLRXZQ{OjRiaB?= NVz5e|c3TE2VTx?= MWTT[Y5{cXSrenXzJJJme2m|dHHueEBk\WyuczD0c{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDzc5Ji\mWwaXK= NIL0OmgzOTJyNUmyOS=>
OCUT1 cells harbored PIK3CA (H1047R+/+) NETWOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX[zJO69VQ>? NH3GNoM2KGR? NWL2cmFlTE2VTx?= MmT3TWM2OD1yLkG0JO69VQ>? M{nOTFIyOjh7Mk[3
K1 cells harbored PIK3CA (E542K+/+) MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHZbnI{KM7:TR?= MnHyOUBl NUnCZ4dqTE2VTx?= NVnpUmRCUUN3ME2wMlUzKM7:TR?= MYOyNVI5QTJ4Nx?=
FTC133 cells harbored PTEN (allele deletion and R130+) NHvrVGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33CXlMh|ryP NYnpbYhKPSCm NGC3do1FVVOR NVS2XmVHUUN3ME2wMlE5KM7:TR?= MV[yNVI5QTJ4Nx?=
C643 cells harbored HRAS (G13R+/−) MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;JXVMh|ryP Mn7VOUBl MUTEUXNQ MkPjTWM2OD1yLkK3JO69VQ>? MoDnNlEzQDl{Nke=
Hth7 cells harbored NRAS (Q61R+/−) M3XnTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnOzN{DPxE1? NUKxdG5zPSCm MVjEUXNQ NUTC[3ZzUUN3ME20MlUh|ryP NXH3XXhmOjF{OEmyOlc>
TPC1 cells harbored RET/PTC1 rearrangement NXSzeIs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D0SlMh|ryP MlLuOUBl NGXJZopFVVOR NFewVHRKSzVyPUCuOVkh|ryP MmPKNlEzQDl{Nke=
Hth74 NHjl[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPWN{DPxE1? NYLhPIJ6PSCm NF7MU|hFVVOR NI[y[3dKSzVyPUKuNVkh|ryP NG\hdpMzOTJ6OUK2Oy=>
KAT18 Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILTUXQ{KM7:TR?= NVjEUlE5PSCm M3W4SWROW09? NFTHPVNKSzVyPUSuOlIh|ryP MlrnNlEzQDl{Nke=
SW1736 NHXZc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYexNFAh|ryP M2rpWVUh\A>? MVXEUXNQ MoPnTWM2OD12Nz61OkDPxE1? MU[yNVI5QTJ4Nx?=
WRO MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HNbFExODBizszN NVSzdnlTPSCm NGLxOHNFVVOR NFnuTnJKSzVyPkGwNFAh|ryP M3PyPFIyOjh7Mk[3
TAD2 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XGd|ExODBizszN NWLNNmdyPSCm NFrj[nVFVVOR NVOzTJozUUN3ME6xNFAxKM7:TR?= MV2yNVI5QTJ4Nx?=
LN229 MmO4RZBweHSxc3nzJGF{e2G7 M4DOUlAvPSEQvF2= MnHmOlAhcA>? NGW3RmtFVVOR MUDBeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? MnW3NlIxPTd7MUS=
T98G M{iweWFxd3C2b4Ppd{BCe3OjeR?= Mon2NE42KM7:TR?= M2\nNFYxKGh? MWTEUXNQ NFvLWI9CfWevZX70d{BieG:ydH;n[Y5q[yCnZn\lZ5R{KG:oIHfl[ol1cW6rYh?= NXr0R2J4OjJyNUe5NVQ>
HC11 NITXXY1HfW6ldHnvckBCe3OjeR?= Mnz4NVAh|ryP M2LMV|I1KGh? MVjEUXNQ NILKNJpKdmirYnn0d{DPui2lYYPlbY4h[W6mIFHEVnAhe3mwdHjld4l{ NWG4XIp5OjJ2Mk[2NlE>
MOLT-4 NV\HXVZtS3m2b4TvfIlkKEG|c3H5 MnTHNVAh|ryP NF3Sflc1QCCq MUnEUXNQ Mkf3TWM2OD1zLkhihKnPxE1? M2KzdlIzPjF2MkSz
CEM-R MVTDfZRwfG:6aXOgRZN{[Xl? MoT5NVAh|ryP Mn;YOFghcA>? NILJR5lFVVOR MWTJR|UxRTNwM,MAje69VQ>? M2PHTFIzPjF2MkSz
CEM-S MonTR5l1d3SxeHnjJGF{e2G7 MlHhNVAh|ryP NX;KVWNUPDhiaB?= NETiOVJFVVOR MWjJR|UxRTVwMfMAje69VQ>? MX6yNlYyPDJ2Mx?=
MOLT-4 M17LUGZ2dmO2aX;uJGF{e2G7 NVPlfI5TOTBizszN M{LsTlI1KGh? MlnoSG1UVw>? MWHCcI9kc3NiY3XscJMhcW5idHjlJGcxN0dzIIDoZZNmKG:oIITo[UBk\WyuIHP5Z4xm MVyyNlYyPDJ2Mx?=
MOLT-4 M1GzbGZ2dmO2aX;uJGF{e2G7 MV[05qCK|ryP MYm0JIg> NEm5foRFVVOR MUfJcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFM1GvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> NYPISVV2OjJ4MUSyOFM>
CEM-R NFe5[2xHfW6ldHnvckBCe3OjeR?= MnW3OQKBkc7:TR?= NYnVRpd[PCCq NWfD[3VFTE2VTx?= MVvJcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFNFGvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> M2jYUVIzPjF2MkSz
CEM-S MXHGeY5kfGmxbjDBd5NigQ>? MmfOOQKBkc7:TR?= M123W|QhcA>? NWTRWWxPTE2VTx?= MVzJcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFNVGvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> M4PHSlIzPjF2MkSz
HepG2 cell NIjuVmlMcW6jc3WgRZN{[Xl? MVGyNEDPxE1? NGrRe3MzPCCq MVvEUXNQ NGTzRWRFd3ewcnXneYxifGW|IITo[UBxcG:|cHjvdplt[XSrb36gc4YhSUuW M3m4dlI{Pzl5M{G5
HepG2 cell M3SydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoryN|Ah|ryP MUeyOEBp MmjzSG1UVw>? M4j6R2lvcGmkaYTzJINmdGxiZ4Lve5Rp MonBNlM4QTd|MUm=
HepG2 cell NWThOXhGSXCxcITvd4l{KEG|c3H5 NIXxVXIzOCEQvF2= MWWyOEBp M1Hm[WROW09? MY\JcoR2[2W|IHPlcIwh[XCxcITvd4l{ Mn\GNlM4QTd|MUm=
GEO MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDrOVAxKG6P M{DnSFczKGh? NUTjfoczTE2VTx?= M3Hab2lvcGmkaYTzJINmdGxiZ4Lve5Rp M2jQVlI1PThzMkOx
CNE-1 NH\lcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n1cVExKM7:TR?= NEm0W2k6PiCq NGLVUJRFVVOR MUnJR|UxRTJwOU[g{txO NFLZNlQzPTN|NkmyOS=>
CNE-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljJNVAh|ryP M4rI[|k3KGh? Mo\4SG1UVw>? MXPJR|UxRTRwNUOg{txO M{P3N|I2OzN4OUK1
HONE-1 NWrJRoVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYexNEDPxE1? MVW5OkBp M3:1b2ROW09? M2LZSGlEPTB;Mz6zO{DPxE1? NWXlPZhHOjV|M{[5NlU>
SUNE-1 NUj2Xm9sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYKxNEDPxE1? M1HET|k3KGh? NXXpR2pZTE2VTx?= MWfJR|UxRTBwNUKg{txO MV:yOVM{Pjl{NR?=
CNE-2 M3vlRWZ2dmO2aX;uJGF{e2G7 MVWxNEDPxE1? NUX6ZXZlPDhiaB?= NHrDW5NFVVOR NFraU4tKdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0JIF1KEdz MY[yOVM{Pjl{NR?=
HONE-1 MVTGeY5kfGmxbjDBd5NigQ>? NGrYboYyOCEQvF2= M{\PZ|Q5KGh? Mn7NSG1UVw>? NIXROmFKdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0JIF1KEdz NIi4XpYzPTN|NkmyOS=>
NEC8 NY\0S2dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEm2OVEh|ryP NHHLeJJUSU6JRWK=
P12-ICHIKAWA NWf5W|NoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDYTWM2OD1yLkGxOlIh|ryP NGfUPGJUSU6JRWK=
MDA-MB-175-VII NWH4SVZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH2ydoxKSzVyPUCuNVM4OzhizszN M3\2fXNCVkeHUh?=
AsPC-1 M32zNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrYO|BKSzVyPUCuNlIyOjJizszN MmHoV2FPT0WU
T47D MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKwNoR1UUN3ME2wMlI5OjVizszN NHPQb3ZUSU6JRWK=
HH MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfnTWM2OD1yLkOwNlg{KM7:TR?= NWTrdGl4W0GQR1XS
MOLT-16 NIrUfphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:1VmlEPTB;MD6zNFMzKM7:TR?= NUfMUZNjW0GQR1XS
ES5 NH\GcXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwM{S0OVUh|ryP NU\TPGdmW0GQR1XS
RS4-11 NIrFN2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DUeWlEPTB;MD6zOFYyKM7:TR?= NF[wR3lUSU6JRWK=
KARPAS-45 NWfGNo9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvDT5dJUUN3ME2wMlM4OzJzIN88US=> MnTCV2FPT0WU
NCI-H720 Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTxTWM2OD1yLkO3Olc6KM7:TR?= M2XVPXNCVkeHUh?=
H9 NHHTe2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwM{i4PFMh|ryP MUDTRW5ITVJ?
EFM-19 M331PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTRW|FDUUN3ME2wMlQ1ODFizszN MVvTRW5ITVJ?
SBC-1 NXn3T3hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLGbnNKSzVyPUCuOFQxOzVizszN NYD4TmU3W0GQR1XS
A4-Fuk NHzaXXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjkTWM2OD1yLkS2PFY5KM7:TR?= MYjTRW5ITVJ?
NCI-H1563 NVe5UYI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKzTWM2OD1yLkS4NVg6KM7:TR?= M3zYRXNCVkeHUh?=
HCC1419 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mki1TWM2OD1yLkS4PFkzKM7:TR?= NFLMbotUSU6JRWK=
H-EMC-SS MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkK1TWM2OD1yLkS5PVM6KM7:TR?= Mn;GV2FPT0WU
BHT-101 M3fNN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwNUK5OlEh|ryP NIHSSI5USU6JRWK=
IGROV-1 M3\5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PObWlEPTB;MD61OVI1QSEQvF2= NWnrUZVWW0GQR1XS
HGC-27 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwNU[3PFMh|ryP NV;wdnhGW0GQR1XS
MDA-MB-361 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3GzRWlEPTB;MD61O|c3OSEQvF2= MX3TRW5ITVJ?
KE-37 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\FW5c4UUN3ME2wMlU5OjZizszN NVmxWoZZW0GQR1XS
HCC70 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwNUm4Nlch|ryP MX7TRW5ITVJ?
LNCaP-Clone-FGC NV7FNoR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7UTWM2OD1yLk[xNFQ5KM7:TR?= MmDoV2FPT0WU
HAL-01 NWTIN4k3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX2TWM2OD1yLk[yNVMh|ryP NIDZT2FUSU6JRWK=
HT MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzuVIJKSzVyPUCuOlMzOzlizszN MmjDV2FPT0WU
MDA-MB-415 MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;aTGlEPTB;MD62N|YzPiEQvF2= Ml7oV2FPT0WU
NOS-1 M3TiPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDVd5ZKSzVyPUCuOlM4OjNizszN MWfTRW5ITVJ?
DU-145 NFfOUWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XaV2lEPTB;MD62OFc1PSEQvF2= Mn\tV2FPT0WU
OCUB-M MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljSTWM2OD1yLkewPVY3KM7:TR?= MoPXV2FPT0WU
VA-ES-BJ MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLDTWM2OD1yLkezNFI2KM7:TR?= M1LqXXNCVkeHUh?=
J-RT3-T3-5 M2\R[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnFbWFxUUN3ME2wMlc1PDB|IN88US=> NWPBd3ZJW0GQR1XS
MOLT-4 NXXIVlk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwOEC1PFIh|ryP NXLBT41jW0GQR1XS
NB7 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z3cmlEPTB;MD64NlQyOSEQvF2= MUDTRW5ITVJ?
L-363 MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvyd4JCUUN3ME2wMlg{PDR{IN88US=> NEfZfZVUSU6JRWK=
NKM-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwOE[yOVMh|ryP NXzQWoZQW0GQR1XS
HOP-92 NFf3dZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwOEeyNlMh|ryP NXjtUYZwW0GQR1XS
OAW-42 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwOEi3NkDPxE1? MXPTRW5ITVJ?
HuO9 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TPR2lEPTB;MD65Nlc2OSEQvF2= NY\FfZVxW0GQR1XS
MFE-280 NV3qTFg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7yd2x1UUN3ME2wMlk3PDZ3IN88US=> MlzMV2FPT0WU
EM-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjlfppKSzVyPUCuPVc6OzlizszN M2fGWHNCVkeHUh?=
NCI-H520 NXrr[oZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:0TWM2OD1yLkm4OVkzKM7:TR?= Ml7PV2FPT0WU
LB2241-RCC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHtZ|FKSzVyPUCuPVk4OzRizszN MUPTRW5ITVJ?
SK-NEP-1 NWLj[4FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSwTWM2OD1zLkG0OFg2KM7:TR?= MYrTRW5ITVJ?
LXF-289 NH7BeIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvUO4ZvUUN3ME2xMlE4OTV4IN88US=> NHPi[JFUSU6JRWK=
EPLC-272H MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTFwMUeyOVYh|ryP NH7JZ4tUSU6JRWK=
COLO-684 NFrpcWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\HcGlKSzVyPUGuNlM4OjVizszN MkHMV2FPT0WU
ES1 NFT4PIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfqfIU6UUN3ME2xMlI1ODZ3IN88US=> NVLjclk3W0GQR1XS
DOHH-2 NVjWOpFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX5TWM2OD1zLkK4NlA{KM7:TR?= M4jOO3NCVkeHUh?=
CTB-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHlVVJKSzVyPUGuNlg6QSEQvF2= M1zNTXNCVkeHUh?=
G-401 MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfX[IdKSzVyPUGuNlk4QTVizszN NXLpe|BDW0GQR1XS
LoVo MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITIPYlKSzVyPUGuN|I2OzRizszN M{H5NHNCVkeHUh?=
Ramos-2G6-4C10 NWm5RphjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTOfFRVUUN3ME2xMlM{PzBzIN88US=> M2TzWnNCVkeHUh?=
MFM-223 NWjqcVk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TMWGlEPTB;MT6zOFQ3OSEQvF2= M3HiTHNCVkeHUh?=
PA-1 M{i5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK3OZd1UUN3ME2xMlM2OjZ3IN88US=> Mn;TV2FPT0WU
697 NIHNNpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfGTWM2OD1zLkO3OlE3KM7:TR?= NYew[WFzW0GQR1XS
QIMR-WIL MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHnTWM2OD1zLkS5NVE3KM7:TR?= M36zZ3NCVkeHUh?=
HOS MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjWTWM2OD1zLkS5OVU5KM7:TR?= Mm\wV2FPT0WU
DMS-273 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DicWlEPTB;MT61NVk2QSEQvF2= NFTBbWZUSU6JRWK=
ME-180 M2fJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFwNU[4PVEh|ryP MWLTRW5ITVJ?
HCC2218 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHKTWM2OD1zLk[4NlI2KM7:TR?= Mn;JV2FPT0WU
CAL-54 NV7TbldiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XtUGlEPTB;MT63NVI1OiEQvF2= NWnKcFR7W0GQR1XS
OMC-1 M1XJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3FVIxFUUN3ME2xMlc1Pjd5IN88US=> MYfTRW5ITVJ?
COR-L105 NHPhTlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe4[YV2UUN3ME2xMlc6PzN5IN88US=> M{HBWXNCVkeHUh?=
BV-173 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTFwOEGwO|Qh|ryP MmXtV2FPT0WU
RKO M4[2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLnOZI4UUN3ME2xMlg4OTBzIN88US=> M1\Zb3NCVkeHUh?=
SNU-387 M4nremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnHUYszUUN3ME2xMlg5PDB4IN88US=> MYTTRW5ITVJ?
SW1088 NGTt[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmwSG9KSzVyPUGuPVQ3ODZizszN MmHkV2FPT0WU
Hs-578-T MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHGW4psUUN3ME2yMlEyPDN|IN88US=> MWDTRW5ITVJ?
OC-314 MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJwMUWwPFYh|ryP MmHNV2FPT0WU
RMG-I NXGyU3hGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTqVoRNUUN3ME2yMlE3Ozl6IN88US=> NULs[VFpW0GQR1XS
NCI-H1395 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly2TWM2OD1{LkG4NFkyKM7:TR?= NFK5O4ZUSU6JRWK=
GAMG NFz6SmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJwMkO4OFUh|ryP MW\TRW5ITVJ?
LB1047-RCC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJwMkSzNVch|ryP MXrTRW5ITVJ?
MN-60 NYq0cZk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXkbVRKSzVyPUKuNlk6OjNizszN MmDzV2FPT0WU
OAW-28 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjhfVBzUUN3ME2yMlI6QTVzIN88US=> NW[wemtoW0GQR1XS
NCI-H2228 NFjFbJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS1WG9rUUN3ME2yMlMyPTV{IN88US=> NGC3cGRUSU6JRWK=
ABC-1 MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjtTWM2OD1{LkOzNlU{KM7:TR?= MojMV2FPT0WU
LS-513 NXO0WlJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGSzS5dKSzVyPUKuN|M1QDRizszN NYi1Z404W0GQR1XS
KS-1 M2XibGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37wRWlEPTB;Mj6zPFE6OSEQvF2= MX7TRW5ITVJ?
NB69 MlXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJwM{i5PFMh|ryP MVXTRW5ITVJ?
VM-CUB-1 MmfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\yTWM2OD1{LkO5NFg{KM7:TR?= NGfpXGRUSU6JRWK=
D-423MG NHjQOpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ri[WlEPTB;Mj60NVA1PCEQvF2= MXnTRW5ITVJ?
EW-18 MoHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Lm[GlEPTB;Mj60NVk{QSEQvF2= NYDneWpoW0GQR1XS
YH-13 MomyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fPV2lEPTB;Mj60OlE2OyEQvF2= NET3ZmxUSU6JRWK=
T-24 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXiTWM2OD1{LkS3PFgyKM7:TR?= MnrFV2FPT0WU
ES8 Mo\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJwNEmyPFch|ryP M{\pSXNCVkeHUh?=
ES3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvBdlVvUUN3ME2yMlQ6PzV7IN88US=> NFHpNnFUSU6JRWK=
RXF393 NEXwfpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHWOVBKSzVyPUKuOlA1QDdizszN MWnTRW5ITVJ?
RPMI-8226 NEK2RllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jtTGlEPTB;Mj62Nlk2OyEQvF2= MVHTRW5ITVJ?
AGS NEnTRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfq[WE6UUN3ME2yMlczOTN5IN88US=> NF3sUo5USU6JRWK=
HCC1395 NV7S[WJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXezdpBqUUN3ME2yMlc2OTh5IN88US=> NVrJPFlwW0GQR1XS
MV-4-11 NHq4RVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjZTWM2OD1{Lke1NlY3KM7:TR?= NYnabVViW0GQR1XS
A204 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJwOEO4O|Ih|ryP MWrTRW5ITVJ?
MCF7 NXjIbo14T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrTdlhxUUN3ME2yMlg3OTF5IN88US=> NYDKU5B2W0GQR1XS
SNU-423 NVvwUm1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojDTWM2OD1{Lki5NlQzKM7:TR?= NI\uU|NUSU6JRWK=
NCI-H1048 NYjLWFl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW0TowyUUN3ME2yMlk3QDZ3IN88US=> MnHsV2FPT0WU
GR-ST NUfhfHplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfHO4hKUUN3ME2zMlA1PjFzIN88US=> MkHXV2FPT0WU
EoL-1- M4nLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPYc5NrUUN3ME2zMlA4ODV6IN88US=> NULSOlRwW0GQR1XS
HuH-7 MnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfZeoZKSzVyPUOuNFk1PjRizszN M4\4XnNCVkeHUh?=
OS-RC-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7YTWM2OD1|LkGxNVkh|ryP MmXXV2FPT0WU
EW-3 NWDzVW5zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEe1V41KSzVyPUOuNVk2OjlizszN M1nubHNCVkeHUh?=
NCI-H747 NV:1NXVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq0RmxmUUN3ME2zMlIxPjl2IN88US=> M2j5SXNCVkeHUh?=
EW-16 NXn0bFlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfFSm5KSzVyPUOuNlE5PzlizszN M1jaR3NCVkeHUh?=
DOK NFTvNYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIi4dWNKSzVyPUOuNlI5PTlizszN NUjWUZVSW0GQR1XS
HCC2157 Mn7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHQcYlKSzVyPUOuN|gyPzlizszN M4Lu[nNCVkeHUh?=
OVCAR-3 Ml\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlOxTWM2OD1|LkSwO|g3KM7:TR?= NFTnc4JUSU6JRWK=
NCI-H1623 NYnhOZhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLRcoNIUUN3ME2zMlQyOjJ2IN88US=> MVXTRW5ITVJ?
H4 MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\iR2dKSzVyPUOuOFU3OjZizszN Ml7JV2FPT0WU
SW1710 NIWyTnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fOS2lEPTB;Mz60OlY4QCEQvF2= NEDYbJNUSU6JRWK=
RT-112 NGmwXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXWTWM2OD1|LkWyN|g5KM7:TR?= Ml;NV2FPT0WU
DMS-114 MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTNwNkKyO|gh|ryP NULVc5VsW0GQR1XS
AN3-CA M2j4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTNwNkK0OVYh|ryP NHfRbmFUSU6JRWK=
KNS-62 M{DNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\GfmlEPTB;Mz62N|M{QCEQvF2= NYr5dZVwW0GQR1XS
SJRH30 NV;IbIoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\pTWM2OD1|Lk[5NVIzKM7:TR?= MXjTRW5ITVJ?
G-402 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D5W2lEPTB;Mz63NFcyOSEQvF2= NYfRTFRUW0GQR1XS
MHH-PREB-1 NF3QRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3CTWM2OD1|LkeyNFM5KM7:TR?= MXXTRW5ITVJ?
P30-OHK NFLZ[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPUTIZKSzVyPUOuPFA6PzZizszN NULIVY04W0GQR1XS
RVH-421 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojuTWM2OD1|LkixO|g5KM7:TR?= MXPTRW5ITVJ?
LU-134-A NYm2bZF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTGTWM2OD1|Lki4OFI5KM7:TR?= MoTZV2FPT0WU
ECC10 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPCTWM2OD1|LkmzOlIzKM7:TR?= M3v6V3NCVkeHUh?=
TGW M4PZb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTvTWM2OD12LkCyN|A2KM7:TR?= NHfES|ZUSU6JRWK=
MLMA MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\CRoRrUUN3ME20MlAzQTZ4IN88US=> NF\kXpZUSU6JRWK=
SCC-25 MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvQeVJKSzVyPUSuNFY2PjZizszN MY\TRW5ITVJ?
TYK-nu M2LaRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;WXmxmUUN3ME20MlA6PTN2IN88US=> MlvIV2FPT0WU
LAMA-84 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTtTWM2OD12LkG0NVkyKM7:TR?= NF3F[ZBUSU6JRWK=
Calu-3 NVvYRmx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmGwTWM2OD12LkK0OFE3KM7:TR?= NHvwd3hUSU6JRWK=
NCI-H460 NG\kZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTRwMk[0OFMh|ryP M17I[nNCVkeHUh?=
EGI-1 NHfRWINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2G1VWlEPTB;ND6zO|c4QCEQvF2= NIHKUnVUSU6JRWK=
NCI-H292 NEjyR2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXWXoZKSzVyPUSuN|gyPDZizszN MYLTRW5ITVJ?
HCE-T M{HMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTRwNEG1O|kh|ryP M4jWUHNCVkeHUh?=
EW-11 NILRcI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPXVJNYUUN3ME20MlQyQDN6IN88US=> MW\TRW5ITVJ?
ATN-1 M33iTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn3dmk2UUN3ME20MlQ1OzB2IN88US=> M3P3Z3NCVkeHUh?=
NB5 M{HBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfOZWFKSzVyPUSuOVM3QTdizszN MUfTRW5ITVJ?
KLE MoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXixW4VVUUN3ME20MlcxOTl6IN88US=> MYfTRW5ITVJ?
CAL-39 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvCTWM2OD12LkeyNVQ3KM7:TR?= NGLLPXBUSU6JRWK=
TI-73 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPsXlNLUUN3ME20MlgxPjB7IN88US=> MmLRV2FPT0WU
HO-1-N-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LqN2lEPTB;ND65OFIh|ryP NGX5XXBUSU6JRWK=
786-0 MlKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHvXlF7UUN3ME20Mlk1Pjd|IN88US=> NWT6dGVnW0GQR1XS
SK-N-DZ M3rLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTRwOU[xOFIh|ryP MXHTRW5ITVJ?
NCI-H446 NFj1XmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LFOWlEPTB;NT6yNFAxQSEQvF2= MVXTRW5ITVJ?
ETK-1 NIHBdVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPmdIlKSzVyPUWuNlEyPjVizszN MnLRV2FPT0WU
BT-20 NWLJZ4pYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK3TWM2OD13LkKxN|U{KM7:TR?= MlvNV2FPT0WU
MEL-HO NEDveWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnIVm1KSzVyPUWuN|c{OzZizszN NUDhXWo6W0GQR1XS
CAL-27 M2HMbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTVwNE[zN|kh|ryP NVfPWYh3W0GQR1XS
SW872 MlK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLkfmdbUUN3ME21MlU6PDJ6IN88US=> MnPWV2FPT0WU
RPMI-2650 NGfwbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfCPYtWUUN3ME21MlY3OTl7IN88US=> MnnlV2FPT0WU
PFSK-1 M2PyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jUR2lEPTB;NT63Nlc{OiEQvF2= NXvUWJVLW0GQR1XS
SF295 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDtcZY2UUN3ME21MlgxPjN|IN88US=> Ml\tV2FPT0WU
Becker MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDtTWM2OD13Lki2OFczKM7:TR?= NWT6O4Q1W0GQR1XS
Saos-2 NGrHVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTVwOE[1N{DPxE1? NGT1S5FUSU6JRWK=
SK-OV-3 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf2TWM2OD13Lkm5PFE3KM7:TR?= M4D0S3NCVkeHUh?=
VMRC-RCZ NY\3RXNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm2Z2dKSzVyPU[uNFg4PzNizszN M3joeHNCVkeHUh?=
EW-22 M3nyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nNZ2lEPTB;Nj6xPVY1QSEQvF2= MlqzV2FPT0WU
BT-474 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHywOVJKSzVyPU[uNlM{KM7:TR?= NXe0eIttW0GQR1XS
BFTC-909 MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjScZVKSzVyPU[uN|A{PDVizszN MVfTRW5ITVJ?
NB12 M2TMTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFy5UI5KSzVyPU[uN|kxPzFizszN NHfDUJpUSU6JRWK=
D-263MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHu[nZKSzVyPU[uOFUyPjlizszN Mke5V2FPT0WU
SNB75 MnnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrOVpBKSzVyPU[uOlAyPDNizszN NVnPR3RHW0GQR1XS
A704 MkD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jEZWlEPTB;Nj62N|A3KM7:TR?= M3G3b3NCVkeHUh?=
NCI-H1693 NUPXOWp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XKemlEPTB;Nj62N|YxPCEQvF2= MnHWV2FPT0WU
LN-405 Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M174dGlEPTB;Nj63PVY4OiEQvF2= MofiV2FPT0WU
CHL-1 NUC2bVJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rVV2lEPTB;Nj64NFA4QSEQvF2= NYLVe2RiW0GQR1XS
A498 NVXscG0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmWxTWM2OD14LkixPVYyKM7:TR?= NYGzdHFKW0GQR1XS
TE-12 NUnzfJdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWmx[254UUN3ME22Mlg{QDF5IN88US=> M1q5NnNCVkeHUh?=
TE-6 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHroOIRKSzVyPU[uPVMxOzhizszN MkC4V2FPT0WU
AU565 NXf1[ok2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe3cHoxUUN3ME22Mlk3QTV5IN88US=> NVzwSpg1W0GQR1XS
RD NVTkRZltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzHS|RKSzVyPU[uPVgzQDRizszN M2TJVnNCVkeHUh?=
SW1463 NGjHWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\se|J5UUN3ME23MlEyOTZ6IN88US=> M3;ne3NCVkeHUh?=
LU-99A NF3HTWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljqTWM2OD15LkG0N|IzKM7:TR?= MUjTRW5ITVJ?
NCI-H28 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTdwMkmyOEDPxE1? MlHmV2FPT0WU
MC-IXC MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T1NWlEPTB;Nz60PFU4PiEQvF2= MkLDV2FPT0WU
GP5d Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr1[o1WUUN3ME23MlQ5PzZ2IN88US=> MVXTRW5ITVJ?
GB-1 NHywOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTdwNUS4NFQh|ryP NETTV2tUSU6JRWK=
CAL-33 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTdwNk[yN|Mh|ryP MX7TRW5ITVJ?
MSTO-211H NIjjSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XESmlEPTB;Nz62O|M{PiEQvF2= MlfpV2FPT0WU
TE-5 NILIc5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfteJJ3UUN3ME23Mlc6OzN2IN88US=> M3rpeHNCVkeHUh?=
D-566MG NHuyUplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRThwMES0Nlkh|ryP NXq2fJY5W0GQR1XS
JVM-3 NVKxS5VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRThwMUWyOlgh|ryP M1jVNXNCVkeHUh?=
T98G NHK0[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\uRWUzUUN3ME24MlE5ODZ5IN88US=> NYj6bWhYW0GQR1XS
HCC1954 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRThwNEWxNFQh|ryP M1XVZnNCVkeHUh?=
SF126 NUW1WG9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;0SmlEPTB;OD60OVk{PiEQvF2= NEfkeWFUSU6JRWK=
LB996-RCC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO5OmdWUUN3ME24MlU{OjV5IN88US=> MVzTRW5ITVJ?
SKG-IIIa MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vPW2lEPTB;OD62N|A3QSEQvF2= MYrTRW5ITVJ?
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SCC-4 M3PxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRThwNkiyNVkh|ryP MWTTRW5ITVJ?
CAMA-1 NGPCXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjBc25pUUN3ME24Mlc4OTR4IN88US=> MW\TRW5ITVJ?
D-502MG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT3TWM2OD16Lke4OlI6KM7:TR?= MVzTRW5ITVJ?
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8505C MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjNbpJKSzVyPUmuNFQzOzJizszN MYjTRW5ITVJ?
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MDA-MB-157 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHITWM2OD17LkmyPFc5KM7:TR?= M1rmNXNCVkeHUh?=
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OVCAR-5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITjdmRKSzVyPUGwMlI1OzNizszN NHfaZXlUSU6JRWK=
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SF539 M{jjd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH5bmZRUUN3ME2xNE46ODRzIN88US=> MnrlV2FPT0WU
A388 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXC[FVlUUN3ME2xNU4{QDl5IN88US=> M4XofnNCVkeHUh?=
DEL NF7GZ|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K1V2lEPTB;MUGuOFI1KM7:TR?= M2frTHNCVkeHUh?=
SW954 M1HIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTFzLkS2Olgh|ryP M1jCSXNCVkeHUh?=
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PC-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTFzLkW3OlQh|ryP MojpV2FPT0WU
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RPMI-7951 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTEbXZQUUN3ME2xNk4yQDV2IN88US=> NVvWVmJPW0GQR1XS
RH-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjNb5RKSzVyPUGyMlIyQDRizszN NVnCbo5sW0GQR1XS
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KNS-81-FD M3TPZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjicohJUUN3ME2xNk42QDZ7IN88US=> NVnReG46W0GQR1XS
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SJSA-1 MmC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jk[WlEPTB;MUOuNlMzPyEQvF2= NF\RS4ZUSU6JRWK=
CTV-1 NVjlVIFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYT1dHR[UUN3ME2xN{4{PDVizszN MnP1V2FPT0WU
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CHP-212 M4\CbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnTVW03UUN3ME2xN{46PzN7IN88US=> NWDqVmFnW0GQR1XS
SCC-15 NEXjb3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfuTWM2OD1zMz65O|c2KM7:TR?= M2nOcHNCVkeHUh?=
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NCI-H2291 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LZWmlEPTB;MUSuOVg4QCEQvF2= Mn6yV2FPT0WU
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CAL-120 NHTDSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLNe|J[UUN3ME2xOE44ODJ5IN88US=> NVO4Z3dRW0GQR1XS
NCI-H23 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfyN2xyUUN3ME2xOE44QTl5IN88US=> NEXETG5USU6JRWK=
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OE19 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzWTWM2OD1zNT6xOVQyKM7:TR?= NXXWWHdPW0GQR1XS
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NCI-H1355 MkHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmD1TWM2OD1{MD6zN|c1KM7:TR?= MljHV2FPT0WU
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IST-MEL1 NEDIe5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTh4Lki4O|Ih|ryP MnP1V2FPT0WU
KP-N-YS NELUbVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrnTWM2OD16OT65NFI5KM7:TR?= NHHofVJUSU6JRWK=
KYSE-410 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLOcW5KSzVyPUmxMlQxPDJizszN MVfTRW5ITVJ?
TE-10 NHLmOGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT3WGdKSzVyPUmxMlU3OTFizszN Mn\TV2FPT0WU
SK-MEL-1 NVTVfI5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV76fmFbUUN3ME25Nk46OTB4IN88US=> MkjrV2FPT0WU
COLO-792 NXXs[nh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS1TWM2OD17NT6yOVY1KM7:TR?= MXPTRW5ITVJ?
SCH NIDjT5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i3Z2lEPTB;OU[uN|g4PyEQvF2= M3vX[XNCVkeHUh?=
NCI-H1792 NFLlZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPtV2NLUUN3ME25Ok45QTl{IN88US=> NXjYdmN4W0GQR1XS
NCI-H2029 NIDBdm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn0WlhqUUN3ME25Ok46PTZ4IN88US=> Mn;rV2FPT0WU
SW684 NHvxelZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoGzTWM2OD17OD62OlU1KM7:TR?= NYXBPIo2W0GQR1XS
NCI-H209 NUPjbWZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFyMD6xNlEh|ryP M4HUXHNCVkeHUh?=
HLE MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3OxUWlEPTB;MUC1MlI5OiEQvF2= Mkj0V2FPT0WU
GOTO MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XKdmlEPTB;MUC3Mlc4PyEQvF2= MnnaV2FPT0WU
NCI-H1793 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYO0b2tjUUN3ME2xNFkvOjhizszN MnnMV2FPT0WU
D-392MG NIDIZ4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLWSW9KSzVyPUGxO{4{QThizszN MX7TRW5ITVJ?
SW1990 MmDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HzZWlEPTB;MUKwMlk2OSEQvF2= MlrQV2FPT0WU
ML-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPBV2xKSzVyPUGyNU43PzZizszN NYnKN2dIW0GQR1XS
NCI-H2452 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXsV2pKSzVyPUGyNk4zOSEQvF2= NYrmWHp1W0GQR1XS
SK-MEL-30 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlX3TWM2OD1zMkOuNlQ1KM7:TR?= M371WHNCVkeHUh?=
SN12C M1XVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTF{ND6xO|Yh|ryP MmThV2FPT0WU
NCI-H1770 MnTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjWTWM2OD1zMkWuOVE1KM7:TR?= M2nTfXNCVkeHUh?=
SF268 M2Dse2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfaR|c1UUN3ME2xNlYvOTV6IN88US=> NFvXVpNUSU6JRWK=
BALL-1 M3vK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf0cZY1UUN3ME2xNlYvOjNizszN NUi0fIJYW0GQR1XS
COLO-679 NUPvNJhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjpeWdKSzVyPUGyOk44PTNizszN NGjNXpNUSU6JRWK=
A2780 NXmxbWZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTCXFFqUUN3ME2xNlgvQTh6IN88US=> Mkn2V2FPT0WU
NCI-H1651 NYnKTFlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnMdJlKSzVyPUGzNU4zPDNizszN MnnqV2FPT0WU
NCI-H2087 Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfPTWM2OD1zM{GuOFg{KM7:TR?= MWDTRW5ITVJ?
U-87-MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTF|Mz62NFQh|ryP MmfJV2FPT0WU
LB2518-MEL MlezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV31TZcxUUN3ME2xN|UvQTl|IN88US=> NEi4W4hUSU6JRWK=
HCT-116 NG\o[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4CydWlEPTB;MUO3MlIyPyEQvF2= MmX6V2FPT0WU
Ca9-22 NGHRZo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTF|OT64N|Mh|ryP NFriPHJUSU6JRWK=
COR-L88 NXLONXdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjsc3VmUUN3ME2xOFIvOTRizszN MmDkV2FPT0WU
CP50-MEL-B M4OySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTF2ND61NFEh|ryP NXnnOnBJW0GQR1XS
OVCAR-8 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\xPGxKSzVyPUG0OU43OzZizszN MlP1V2FPT0WU
SK-MEL-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmOzTWM2OD1zNEeuPFc5KM7:TR?= NILyWZhUSU6JRWK=
GT3TKB MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVmwXm5[UUN3ME2xOFkvQTJ6IN88US=> MX7TRW5ITVJ?
KYSE-450 M33kW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPNTWM2OD1zNUGuOVM6KM7:TR?= M2rn[XNCVkeHUh?=
CAPAN-1 NGT2WpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHZTWM2OD1zNUOuNFY1KM7:TR?= NUPycHc6W0GQR1XS
BEN NU\xS5lMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn21TWM2OD1zNUOuPVI5KM7:TR?= MVXTRW5ITVJ?
NCI-H1304 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX6UZZTUUN3ME2xOVQvPjl2IN88US=> NHu1cmdUSU6JRWK=
KU812 NWTXNWNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTF3OD62O|Qh|ryP NI\KV5pUSU6JRWK=
Capan-2 NYqzPI1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\MZ2RKSzVyPUG2NE42PTNizszN NY[5fGVUW0GQR1XS
A673 NUm2dXliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni2TWM2OD1zNkGuO|A2KM7:TR?= NVr6SJpsW0GQR1XS
SAS NWnMXpRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW5UHp1UUN3ME2xOlIvPjd6IN88US=> NVP4ToF[W0GQR1XS
NY M3zxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULSNHdnUUN3ME2xOlUvOzF2IN88US=> MX\TRW5ITVJ?
HCE-4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDCVVdKSzVyPUG2Ok45PDVizszN MlH4V2FPT0WU
MDA-MB-231 NX;Me4RGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUizW3RDUUN3ME2xO|cvPTB|IN88US=> NFe4bnNUSU6JRWK=
no-10 NVPtXo91T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF5OD6xN|Qh|ryP MWTTRW5ITVJ?
MZ7-mel MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7BTWM2OD1zN{iuOFY4KM7:TR?= MVrTRW5ITVJ?
NCI-H82 NXTQOWtvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTMTZdKSzVyPUG4NE4yPjVizszN NWW4VG11W0GQR1XS
CAL-72 NVv0e41TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPzbGVKSzVyPUG4OU4xPTRizszN NYXv[mRFW0GQR1XS
NCI-SNU-5 NU\3UY1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfXZmZFUUN3ME2xPFYvQDRizszN NI[4bXVUSU6JRWK=
OVCAR-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml63TWM2OD1zOEiuN|M{KM7:TR?= MlvGV2FPT0WU
SCC-9 NYDP[4U{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:4cJh1UUN3ME2xPVEh|ryP MnjkV2FPT0WU
KYSE-150 M3PlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzkV|RKSzVyPUG5NU45QDhizszN NITtbWVUSU6JRWK=
HT-29 MkH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJyMT6yNVIh|ryP MXTTRW5ITVJ?
COLO-678 MkjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHWVXRKSzVyPUKwNU41PSEQvF2= MUnTRW5ITVJ?
NCI-H650 MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXyfXJKSzVyPUKwNk4yODNizszN NVzE[Y1nW0GQR1XS
HuCCT1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJyND6yNFgh|ryP MlvZV2FPT0WU
SW1116 MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Dn[mlEPTB;MkC3MlA4PyEQvF2= MlvJV2FPT0WU
DBTRG-05MG Mlz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJyNz65NFkh|ryP NHHqVIlUSU6JRWK=
SW982 Ml;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJyNz65OFgh|ryP MXPTRW5ITVJ?
RCM-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJzND63OlIh|ryP NV6yNoR[W0GQR1XS
COLO-320-HSR MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTEdJBKSzVyPUKxOk4yOjVizszN NUfxc2JNW0GQR1XS
KNS-42 NX;kNZp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPaVG1[UUN3ME2yNVYvPTd2IN88US=> Mk\jV2FPT0WU
C2BBe1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJ|MT65NFUh|ryP NGfTZoRUSU6JRWK=
CCRF-CEM NXOyT211T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJ2Mz63PVUh|ryP NYLwSZRCW0GQR1XS
SH-4 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJ2Nj6wPUDPxE1? NEDGSpJUSU6JRWK=
LS-1034 NWj6V5F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDKN2tiUUN3ME2yOFYvOjZ4IN88US=> NIrKO|ZUSU6JRWK=
NCI-H2347 NVfGNJA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJ2Nz63NVMh|ryP MWjTRW5ITVJ?
RPMI-8866 NXWwenFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\Fc2lEPTB;MkS5MlI4KM7:TR?= MUDTRW5ITVJ?
GAK MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTiVoxKUUN3ME2yOVMvODB{IN88US=> MlfhV2FPT0WU
NB6 M325c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJ5MD6xJO69VQ>? MljiV2FPT0WU
COLO-680N NV65NnFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPMSpBVUUN3ME2yO|IvPTJ5IN88US=> NHPFcpVUSU6JRWK=
RERF-LC-MS NUXic|dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJ5Nj6wNFch|ryP NIe5Z3hUSU6JRWK=
TGBC11TKB NF;ifXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33rXWlEPTB;Mke4MlE4QCEQvF2= M3T4THNCVkeHUh?=
C8166 Ml\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTJUIlKSzVyPUK3PE42ODZizszN NIi5cVBUSU6JRWK=
HDLM-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJ7ND60NFkh|ryP NH;U[WlUSU6JRWK=
IGR-1 MknwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rEO2lEPTB;Mkm1MlY2QSEQvF2= MnLTV2FPT0WU
FADU Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHWeHpKSzVyPUK5O{42OSEQvF2= NULDPGtnW0GQR1XS
L-428 NFzzN5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrlTWM2OD1{OUeuOlE3KM7:TR?= M3HyOXNCVkeHUh?=
LU-65 NV7lVJBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jCZ2lEPTB;M{C0MlMzKM7:TR?= M1vOT3NCVkeHUh?=
HEL NILRZ29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\Td3JpUUN3ME2zNFkvQTh|IN88US=> NIjoW3hUSU6JRWK=
NCI-H810 M4XxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNzMD61O{DPxE1? MX;TRW5ITVJ?
C3A MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmK5TWM2OD1|MUGuPFAzKM7:TR?= MkjKV2FPT0WU
NCI-H630 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFW4N4FKSzVyPUOzNk4zQTRizszN MkSxV2FPT0WU
KP-N-YN MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rvNGlEPTB;M{SxMlEzOyEQvF2= MYrTRW5ITVJ?
MOLT-13 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iy[WlEPTB;M{SyMlMzPiEQvF2= MVjTRW5ITVJ?
NCI-H1993 NWroVJlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLyTWM2OD1|NEKuN|Y2KM7:TR?= MnjxV2FPT0WU
BE-13 MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTN2ND6xOlch|ryP NHiyV5lUSU6JRWK=
IST-SL1 NYrnV3p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3frWGlEPTB;M{S3MlQxOSEQvF2= MVvTRW5ITVJ?
TE-9 M1LGOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HacGlEPTB;M{[zMlU5QSEQvF2= NV\6eIxwW0GQR1XS
LU-135 M3fOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfaTWM2OD1|NkeuNFM2KM7:TR?= NFTQb|JUSU6JRWK=
T84 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;0TWM2OD1|N{SuO|EzKM7:TR?= NWS2[Il1W0GQR1XS
K-562 M2XFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTN6Mz6zOkDPxE1? MYjTRW5ITVJ?
SBC-5 NVfyR|Z5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTN6Nj65PFUh|ryP M{exTXNCVkeHUh?=
NB17 M1rremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\2TWM2OD1|OUKuOVk3KM7:TR?= NIm2fWJUSU6JRWK=
NCI-H2052 NG\2OXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\nNm9KSzVyPUO5PE41PzJizszN MVrTRW5ITVJ?
HCC38 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DWbGlEPTB;NECxMlU6OyEQvF2= MWLTRW5ITVJ?
NCI-H69 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTR2MT6wPFMh|ryP MoTHV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

カスタマーフィードバック (18)


Click to enlarge
Rating
Source , , Cell, 2015, 160(1-2): 161-76 . MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines Ser78 cells
Concentrations 5 µM
Incubation Time 1 h
Results Two selective AKT inhibitors MK-2206 and GDC-0068, both significantly reduced MKK4 phosphorylation on Ser78 in axons after injury.

Click to enlarge
Rating
Source Cancer Cell, 2013, 24, 766-76. MK-2206 2HCl purchased from Selleck
Method analysis of luciferase activity
Cell Lines immunodeficient NOG mice
Concentrations 10 mg kg-1
Incubation Time 3 days
Results In this experiment, animalstreated with dexamethasone or MK2206 showed progressivetumor growth similar to that observed in vehicle-treated controls,while mice treated with MK2206 plus dexamethasone had significant antitumor responses.

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Source Cancer Discov, 2012, 2, 934-47. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines PC9GR4/WZR10 cells
Concentrations 1 uM
Incubation Time 72 h
Results The addition of a dual PI3K and MTOR inhibitor, PI103, or the AKT inhibitor MK-2206, did reduce the expression of pAKT neither in GR4 cells nor WZR10 cells.

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Source J Exp Med, 2014, 211(9), 1741-58. MK-2206 2HCl purchased from Selleck
Method 3D migration model
Cell Lines WT or Rap1b-/- neutrophil
Concentrations 2 uM
Incubation Time
Results MK-2206 treatment completely reversed elevated TEM across mouse endothelial cells of Rap1b-/- neutrophils to WT levels (A). It reduced ECM degradation of Rap1b -/- neutrophils, and inhibited their multiple protrusions (B and C). Furthermore, almost all Rap1b -/- cells treated with MK-2206 were found at the endothelial cell junctions (D).

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Source Nat Commun, 2015, 6:6943. MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines HUVECs
Concentrations 1 uM
Incubation Time 8 h
Results Because YAP is also a known substrate of Akt21, we examined whether blockade of the Akt pathway affects YAP phosphorylation. Both Ly294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and MK-2206, an allosteric inhibitor of Akt, suppressed cell contact-mediated YAP phosphorylation.

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Source Leukemia, 2015, 29(1), 169-76. MK-2206 2HCl purchased from Selleck
Method Immunoblotting
Cell Lines CXCR4S338X-expressing BCWM.1 cells
Concentrations 0.5 uM
Incubation Time 6 h
Results As AKT and ERK, but not BTK, show continued SDF-1a-triggered activation in CXCR4S338X-expressing WM cells treated with ibrutinib, we next sought to clarify if AKT and ERK contributed to the enhanced survival of these cells. It therefore treated SDF-1acultured CXCR4S338X BCWM.1 cells with either AKT- (MK-2206 and AZD-5363) or MEK- (AS-703026, AZD-6244 and UO126) specific inhibitors with and without ibrutinib (0.5 uM) for 6 h so as to clarify the contribution of AKT and ERK to ibrutinib resistance. The inhibitory activity of MK-2206, as well as AS-703026, AZD-6244 and UO126 was confirmed by western blot analysis for pAKT (S473) and pERK (T202/Y204), respectively.

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Source Cancer Res, 2013, 73, 2189-98. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines SKNAS/SJNB8/IMR32/GIMEN/SHEP2/KCNR/NGP/LAN1/LAN5/TR14/UHGNP cell lines
Concentrations 8 μM
Incubation Time 48 h
Results The 8 μM MK-2206 treatments resulted in effective pathway inhibition in all cell lines as shown by western blot for phosphoryl ated FOXO3a and PRAS40 as well as AKT serine 473 phosphorylation.

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Source Oncotarget, 2011, 2, 1109-26. MK-2206 2HCl purchased from Selleck
Method Western blot/ Wst-1 assay
Cell Lines ATC/ FTC cell lines
Concentrations 500 nM
Incubation Time 1 h/72 h
Results One-hour treatment with the AKT inhibitor MK-2206 (0.5 μM) or with the MEK inhibitor U0126 (10 μM) effectively abolished AKT and ERK1/2 phosphorylation in all cell lines.

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Source Sci Signal, 2011, 4, rs9. MK-2206 2HCl purchased from Selleck
Method ELISA
Cell Lines HeLa cells
Concentrations 1 μM
Incubation Time
Results Treatment of infected cells with kinase inhibitors directed at Akt (MK-2206), MEK(PD 98059), PKC(CEC), or Pim family kinases identified a dominant role for Pim family kinases in the release of IL-8 from Salmonella-infected epithelial cells.

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Source FASEB J, 2013, 27, 1644-56. MK-2206 2HCl purchased from Selleck
Method Clonogenic growth assay
Cell Lines U2OS cells
Concentrations 1 μM
Incubation Time 9 d
Results Specific inhibition of PKB activity using MK-2206 or triciribine also significantly reduced cell growth, although to a lesser extent compared to PI-103, suggesting that both the PKB and mTOR pathways are important for anchorage-dependent growth.

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Source Gynecol Oncol, 2011, 123, 13-8. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines ovarian cancer cell lines
Concentrations 1-6 μM
Incubation Time 1 h/72 h
Results Activation of pAKT by IGF-1 in the low-grade cell line HOC-7 was blocked by the AKT inhibitor MK-2206.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Confocal microscopy
Cell Lines platelets
Concentrations 1μM
Incubation Time
Results Upon treatment with increasing concentrations of AEA from 0.1 to 10 mM (Fig. B–D) platelets were fully fluorescently marked as compared to control (Fig. A) and the increase in DAF 2 fluorescence intensity appears to be dose-dependent. In agreement with data shown in Figure 4, SR1(Fig. E) and MK2206 (Fig. F) abolished fluorescence intensity induced by AEA, while LY294002 (Fig. 5G) was less potent.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines platelets
Concentrations 1 μM
Incubation Time
Results eNOSser1177 phosphorylation was greatly reduced by LY294002 and cancelled by MK2206 but it was not modified by platelet pretreatment with EGTA or BAPTA/AM.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Nitriter+Nitrate(NOX) measurement, cGMP detection
Cell Lines platelets
Concentrations 1 μM
Incubation Time 1 min
Results As shown in Figure 4 SR1 significantly reduced both NOx and cGMP formation, while SR2 failed to affect these parameters.

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Source Radiat Oncol, 2009, 4, 43. MK-2206 2HCl purchased from Selleck
Method Western blot, clonogenic survival assay
Cell Lines U87MG cells
Concentrations 1 μM
Incubation Time 1 h
Results Akt inhibitor MK-2206 showed similar effect. MK-2206 is a potent allosteric Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3 respectively. U87MG cells were preincubated with 1 μM MK-2206 for 1 hr, followed by irradiation at 0 - 9 Gy. As shown in Fig C, MK-2206 treatment abolished IR-induced Akt phosphorylation. Moreover, treatment with MK-2206 also increased the radiosensitivity of U87MGcells (Fig. D)

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Source Dr. Zhang of Tianjin Medical University. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines Breast cancer cells
Concentrations 0-10 nM
Incubation Time 3 h
Results Breast cancer cells were serum starved for 24 h, pretreated with the indicated concentrations of MK-2206 for 3 h, and then treated with 100ng/ml EGF for 15 min.

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Source Biochim Biophys Acta, 2012, 1823, 987-96. MK-2206 2HCl purchased from Selleck
Method Immunofluorescence
Cell Lines HC11 cells
Concentrations 10 µM
Incubation Time 1 h
Results whole ADRP levels, estimated by Western blot , decreased only in the presence of MK -2206 and LY294002. In most cases, ADRP decorated the surface of small lipid droplets and appeared as little patches on large cytoplasmic lipid droplets. With the exception of SP600125, which induced a strong ADRP coating of almost all cytoplasmic lipid droplets (although this inhibitor did not increase ADRP synthesis), variation in the distribution of ADRP at the surface of lipid droplet was difficult to estimate, notably because the signal was faint and uneven.

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Source MK-2206 2HCl purchased from Selleck
Method Western blot analysis
Cell Lines MCF-7 cells
Concentrations 0 nM/100 nM/250 nM/1000 nM
Incubation Time 24 h
Results The effect of MK-2206 on the serine 473 phosphorylation mark of AKT 1 was uneven and did not correlate with inhibition of AKT activity, but the AKT1 mutant cells maintained higher levels of AKT1 serine 473 phosphorylation with increasing concentrations of MK-2206. Of note, MK-2206 completely inhibited AKT2 activation at 100 nM, a concentration where PIK3CA E545K mutant, but not AKT1 mutant cells were already strongly growth inhibited. MK-2206 treatment up to 1 μM did not have strong effects on other protein biomarkers such as ribosomal protein S6, ev en though growth was suppressed by approximately 80% in MCF-7 cells at this concentration.

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