MK-2206 2HCl 化学構造
分子量: 480.39

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Quality Control & MSDS

製品説明

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    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HClは高度選択的に Akt1, Akt2 and Akt3を抑制して、 IC50がそれぞれ 8 nM, 12 nM と 65 nMになる。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 NFjwcGxEgXSxdH;4bYMhSXO|YYm= MoXCN{DPxE1? NUXXboQ2PzJiaB?= MU\EUXNQ M{TwcWlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:w NEHKNGEzODV5MUC2PS=>
A431 NG\nfoRMcW6jc3WgRZN{[Xl? NGrvSVA2KM7:TR?= MmnNOUBp NInBbHBFVVOR MnyyV5VxeHKnc4Pld{B1cGVic3nncoFtcW6pIH;mJGFsfCCjbnSgSZJs M2XGTVIxPTdzME[5
HepG2 MlvqR5l1d3SxeHnjJGF{e2G7 NVTHXVJ2OTBizszN M3rDSlI1KGh? NGm1TG5FVVOR NI\NPWxU\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> M33Le|IyOjB3OUK1
Sk-Hep1 M1\mdGN6fG:2b4jpZ{BCe3OjeR?= MnqwNVAh|ryP M3fBPFI1KGh? NXrlfXZITE2VTx?= NHfZb4RU\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> M3nx[lIyOjB3OUK1
OCUT1 cells harbored PIK3CA (H1047R+/+) NHTCU5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7nN{DPxE1? Ml\mOUBl NIX2eZBFVVOR M2raVmlEPTB;MD6xOEDPxE1? NIixbFUzOTJ6OUK2Oy=>
K1 cells harbored PIK3CA (E542K+/+) M3rjPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fWbFMh|ryP M4DPclUh\A>? NWX1WXNtTE2VTx?= NHHudItKSzVyPUCuOVIh|ryP MXuyNVI5QTJ4Nx?=
FTC133 cells harbored PTEN (allele deletion and R130+) M1m4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPacmE{KM7:TR?= NFfSSYg2KGR? MX\EUXNQ MknHTWM2OD1yLkG4JO69VQ>? M3rOblIyOjh7Mk[3
C643 cells harbored HRAS (G13R+/−) MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jQS|Mh|ryP MXe1JIQ> MVLEUXNQ NFf0dndKSzVyPUCuNlch|ryP MYeyNVI5QTJ4Nx?=
Hth7 cells harbored NRAS (Q61R+/−) MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X0PFMh|ryP MV[1JIQ> MnjZSG1UVw>? NWPKfHYxUUN3ME20MlUh|ryP MYmyNVI5QTJ4Nx?=
TPC1 cells harbored RET/PTC1 rearrangement NWmxUXdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D5U|Mh|ryP NHr5[Ys2KGR? MUPEUXNQ M{H5OmlEPTB;MD61PUDPxE1? NU\lO5MzOjF{OEmyOlc>
Hth74 NVOyRWhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nKZVMh|ryP MorCOUBl M4\PRmROW09? M4H3dGlEPTB;Mj6xPUDPxE1? M2PmW|IyOjh7Mk[3
KAT18 NYXiSodkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWezJO69VQ>? MVi1JIQ> NYrJbFE6TE2VTx?= NF\qc2tKSzVyPUSuOlIh|ryP NX24d5NSOjF{OEmyOlc>
SW1736 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjGd5lROTByIN88US=> MlzhOUBl NWHwbHc3TE2VTx?= NXv3[VkzUUN3ME20O{42PiEQvF2= NVS3d|ljOjF{OEmyOlc>
WRO M1HPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPrXY9MOTByMDFOwG0> NHLVZnA2KGR? M3PxNGROW09? M37NbmlEPTB-MUCwNEDPxE1? NHriSHYzOTJ6OUK2Oy=>
TAD2 NWDNclRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLmNVAxOCEQvF2= MW[1JIQ> MmOxSG1UVw>? M3j1NGlEPTB-MUCwNEDPxE1? MnHsNlEzQDl{Nke=
LN229 NUnUSFl1SXCxcITvd4l{KEG|c3H5 MmriNE42KM7:TR?= MWG2NEBp NHu1[5ZFVVOR MWjBeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? MV:yNlA2PzlzNB?=
T98G MmPyRZBweHSxc3nzJGF{e2G7 NUPOUVJFOC53IN88US=> NH3tbVU3OCCq M1TzN2ROW09? M1jzZ2F2\22nboTzJIFxd3C2b3flcolkKGWoZnXjeJMhd2ZiZ3XmbZRqdmmk M374[FIzODV5OUG0
HC11 M2PEbGZ2dmO2aX;uJGF{e2G7 MoP4NVAh|ryP NH32ZXEzPCCq NFHYeHBFVVOR NULSO2I5UW6qaXLpeJMh|rJvY3Hz[YlvKGGwZDDBSHJRKHO7boTo[ZNqew>? NXXmbHRIOjJ2Mk[2NlE>
MOLT-4 M1K3[2N6fG:2b4jpZ{BCe3OjeR?= NHX2V|YyOCEQvF2= MWC0PEBp NIHONW5FVVOR MXLJR|UxRTFwN,MAje69VQ>? Ml\DNlI3OTR{NEO=
CEM-R M3\4XGN6fG:2b4jpZ{BCe3OjeR?= NFjnbFAyOCEQvF2= M3;4OlQ5KGh? NVrH[WJ2TE2VTx?= NHmwU5ZKSzVyPUOuN-KBkc7:TR?= NX;tSnU4OjJ4MUSyOFM>
CEM-S MlXHR5l1d3SxeHnjJGF{e2G7 NX3IPVYyOTBizszN M1fLPFQ5KGh? NXzabY42TE2VTx?= MmrrTWM2OD13LkJihKnPxE1? MmHONlI3OTR{NEO=
MOLT-4 MUnGeY5kfGmxbjDBd5NigQ>? NWXsR4JLOTBizszN Ml7hNlQhcA>? Mn2ySG1UVw>? MknHRoxw[2u|IHPlcIx{KGmwIITo[UBIOC:JMTDwbIF{\SCxZjD0bIUh[2WubDDjfYNt\Q>? Mo\4NlI3OTR{NEO=
MOLT-4 M1TRXmZ2dmO2aX;uJGF{e2G7 MV[05qCK|ryP NUTEZYppPCCq M1LidWROW09? NYTOfmtvUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|NCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ MkLWNlI3OTR{NEO=
CEM-R NYLCfldLTnWwY4Tpc44hSXO|YYm= NUnkb3plPOLCid88US=> NFSzN241KGh? MoHlSG1UVw>? NHW3eVNKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDOGEwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? NULiTZJbOjJ4MUSyOFM>
CEM-S M{LvSWZ2dmO2aX;uJGF{e2G7 M{TzdVTjiIoQvF2= M3vLSFQhcA>? MkW0SG1UVw>? M{f5dWlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFO1RU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? M1rRNlIzPjF2MkSz
HepG2 cell NIP6[JpMcW6jc3WgRZN{[Xl? NUfaTG1qOjBizszN M1zUUFI1KGh? NVy4O49jTE2VTx?= NUXkOI5nTG:5boLl[5Vt[XSnczD0bIUheGixc4Doc5J6dGG2aX;uJI9nKEGNVB?= Ml7MNlM4QTd|MUm=
HepG2 cell MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;Tfms{OCEQvF2= M331[lI1KGh? MlyxSG1UVw>? NEXTO4pKdmirYnn0d{Bk\WyuIHfyc5d1cA>? MoWxNlM4QTd|MUm=
HepG2 cell MkPERZBweHSxc3nzJGF{e2G7 M2LpT|IxKM7:TR?= NV;2epdROjRiaB?= MY\EUXNQ MUTJcoR2[2W|IHPlcIwh[XCxcITvd4l{ NWK5W|VIOjN5OUezNVk>
GEO NX3IcG5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\PXpg2ODBibl2= NVnKUHg6PzJiaB?= MmWxSG1UVw>? M{DNUGlvcGmkaYTzJINmdGxiZ4Lve5Rp M1PYPVI1PThzMkOx
CNE-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUexNEDPxE1? NWjMdIJiQTZiaB?= NEXDflFFVVOR NIDKcndKSzVyPUKuPVYh|ryP MYCyOVM{Pjl{NR?=
CNE-2 MkDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzYbGkyOCEQvF2= NEXzXHo6PiCq MmTTSG1UVw>? NFvJOYRKSzVyPUSuOVMh|ryP M1zOVlI2OzN4OUK1
HONE-1 MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVKxNEDPxE1? NGrOeWE6PiCq MkDKSG1UVw>? NFPUNWNKSzVyPUOuN|ch|ryP MXOyOVM{Pjl{NR?=
SUNE-1 NHvSUpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUGxNEDPxE1? NXLTO4dJQTZiaB?= NX7DOpZ{TE2VTx?= MlrkTWM2OD1yLkWyJO69VQ>? MY[yOVM{Pjl{NR?=
CNE-2 MVXGeY5kfGmxbjDBd5NigQ>? M2rsT|ExKM7:TR?= NWnBWIxVPDhiaB?= MoPJSG1UVw>? MmjxTY5lfWOnczDj[YxtKGO7Y3zlJIFzemW|dDDheEBIOQ>? M1rhflI2OzN4OUK1
HONE-1 NXrh[YNQTnWwY4Tpc44hSXO|YYm= MVKxNEDPxE1? MVm0PEBp M{LWcWROW09? MXjJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy MnXhNlU{OzZ7MkW=
NEC8 NVrNfHhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\oUFNKSzVyPUCuNFk3PTFizszN NUHvclk4W0GQR1XS
P12-ICHIKAWA MkfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTiSlV3UUN3ME2wMlEyPjJizszN MWPTRW5ITVJ?
MDA-MB-175-VII MmjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\NVGlEPTB;MD6xN|c{QCEQvF2= MUTTRW5ITVJ?
AsPC-1 MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S4[WlEPTB;MD6yNlEzOiEQvF2= M1KxTXNCVkeHUh?=
T47D MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMkiyOUDPxE1? NVnmZpRLW0GQR1XS
HH NX:xZmFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW2TWM2OD1yLkOwNlg{KM7:TR?= NVjmcXhRW0GQR1XS
MOLT-16 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3OTWM2OD1yLkOwN|Ih|ryP MV3TRW5ITVJ?
ES5 M1HaU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkG1TWM2OD1yLkO0OFU2KM7:TR?= MoryV2FPT0WU
RS4-11 M2q1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwM{S2NUDPxE1? MXfTRW5ITVJ?
KARPAS-45 NH7tfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwM{ezNlEh|ryP MmDzV2FPT0WU
NCI-H720 NVi5W|RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXZSmRvUUN3ME2wMlM4Pjd7IN88US=> NIrq[|RUSU6JRWK=
H9 M2\4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DNV2lEPTB;MD6zPFg5OyEQvF2= MUfTRW5ITVJ?
EFM-19 NXPrfJhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzmfoFKSzVyPUCuOFQxOSEQvF2= MVLTRW5ITVJ?
SBC-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rsOWlEPTB;MD60OFA{PSEQvF2= M2rnfHNCVkeHUh?=
A4-Fuk MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\PTWM2OD1yLkS2PFY5KM7:TR?= NG\NXotUSU6JRWK=
NCI-H1563 Mk\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfubmc6UUN3ME2wMlQ5OTh7IN88US=> MV7TRW5ITVJ?
HCC1419 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPpTWM2OD1yLkS4PFkzKM7:TR?= NWju[plbW0GQR1XS
H-EMC-SS Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\lcmlEPTB;MD60PVk{QSEQvF2= MV3TRW5ITVJ?
BHT-101 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvaTWM2OD1yLkWyPVYyKM7:TR?= MlfDV2FPT0WU
IGROV-1 NFjiN2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4T2TGlEPTB;MD61OVI1QSEQvF2= MnuwV2FPT0WU
HGC-27 M2e2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwNU[3PFMh|ryP M2DXPXNCVkeHUh?=
MDA-MB-361 MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Xk[2lEPTB;MD61O|c3OSEQvF2= MWXTRW5ITVJ?
KE-37 NUfKNmdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33u[2lEPTB;MD61PFI3KM7:TR?= MoW0V2FPT0WU
HCC70 NFjZVlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzXTWM2OD1yLkW5PFI4KM7:TR?= Mn\iV2FPT0WU
LNCaP-Clone-FGC NVjWZmx7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XVSmlEPTB;MD62NVA1QCEQvF2= M1PoenNCVkeHUh?=
HAL-01 M3;RSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzqTWM2OD1yLk[yNVMh|ryP NYXlVJZxW0GQR1XS
HT NFzYZ4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwNkOyN|kh|ryP Ml3wV2FPT0WU
MDA-MB-415 NGS4TpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzqOG9KSzVyPUCuOlM3OjZizszN M1vRTXNCVkeHUh?=
NOS-1 NGDlcZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrLbnpKSzVyPUCuOlM4OjNizszN NGX2[ZhUSU6JRWK=
DU-145 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TOSWlEPTB;MD62OFc1PSEQvF2= MXfTRW5ITVJ?
OCUB-M Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFe1WIFKSzVyPUCuO|A6PjZizszN M4fzdnNCVkeHUh?=
VA-ES-BJ NWLoO4xWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfrV5dRUUN3ME2wMlc{ODJ3IN88US=> M{DEb3NCVkeHUh?=
J-RT3-T3-5 NYi5SZhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwN{S0NFMh|ryP M3HodnNCVkeHUh?=
MOLT-4 M3[wZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDSc3ZKSzVyPUCuPFA2QDJizszN M4LmZXNCVkeHUh?=
NB7 Mmf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXCTWM2OD1yLkiyOFEyKM7:TR?= NU[1fWNCW0GQR1XS
L-363 NWXyU|JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwOEO0OFIh|ryP M130eXNCVkeHUh?=
NKM-1 MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwOE[yOVMh|ryP NVixUWc6W0GQR1XS
HOP-92 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\6OG5DUUN3ME2wMlg4OjJ|IN88US=> NF\0WXNUSU6JRWK=
OAW-42 M{X4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ezXGlEPTB;MD64PFczKM7:TR?= NFLLfWlUSU6JRWK=
HuO9 NFu3VGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPYZXVwUUN3ME2wMlkzPzVzIN88US=> MXnTRW5ITVJ?
MFE-280 MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV62O5JQUUN3ME2wMlk3PDZ3IN88US=> NFPGOnFUSU6JRWK=
EM-2 M1\xbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D0TWlEPTB;MD65O|k{QSEQvF2= NHXnb4RUSU6JRWK=
NCI-H520 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwOUi1PVIh|ryP MYrTRW5ITVJ?
LB2241-RCC NX6xcFJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwOUm3N|Qh|ryP NH7Ud5pUSU6JRWK=
SK-NEP-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLp[IlKUUN3ME2xMlE1PDh3IN88US=> MYTTRW5ITVJ?
LXF-289 NWO4cGdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHQVYJKSzVyPUGuNVcyPTZizszN NVXubVVMW0GQR1XS
EPLC-272H MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHwU5NDUUN3ME2xMlE4OjV4IN88US=> NWWzdZJ5W0GQR1XS
COLO-684 NUH4PWJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K1cGlEPTB;MT6yN|czPSEQvF2= NV\5PGZFW0GQR1XS
ES1 M3;IO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3rd2x3UUN3ME2xMlI1ODZ3IN88US=> NWG0cGZFW0GQR1XS
DOHH-2 NVvQUGNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInyO4hKSzVyPUGuNlgzODNizszN M{fEeHNCVkeHUh?=
CTB-1 MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\x[WE6UUN3ME2xMlI5QTlizszN NGnN[VhUSU6JRWK=
G-401 NYjPUGVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn4e3NnUUN3ME2xMlI6Pzl3IN88US=> M1jnOXNCVkeHUh?=
LoVo MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwM{K1N|Qh|ryP MXzTRW5ITVJ?
Ramos-2G6-4C10 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLofFdKSzVyPUGuN|M4ODFizszN MV3TRW5ITVJ?
MFM-223 NG\G[mJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml31TWM2OD1zLkO0OFYyKM7:TR?= MlnIV2FPT0WU
PA-1 NYD2TY1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HNS2lEPTB;MT6zOVI3PSEQvF2= MUXTRW5ITVJ?
697 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvpWVc5UUN3ME2xMlM4PjF4IN88US=> MYjTRW5ITVJ?
QIMR-WIL M2f0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjlTWM2OD1zLkS5NVE3KM7:TR?= MXnTRW5ITVJ?
HOS Mo\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrwTWM2OD1zLkS5OVU5KM7:TR?= NFPPfYVUSU6JRWK=
DMS-273 NXnzVWxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jkZmlEPTB;MT61NVk2QSEQvF2= MVXTRW5ITVJ?
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RPMI-8226 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnyTWM2OD1{Lk[yPVU{KM7:TR?= NFv1fGhUSU6JRWK=
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NCI-H1623 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTNwNEGyNlQh|ryP NHzwSHlUSU6JRWK=
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LU-134-A MnLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\JRXRKSzVyPUOuPFg1OjhizszN MX;TRW5ITVJ?
ECC10 Moe0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTNwOUO2NlIh|ryP M1XmSXNCVkeHUh?=
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CAL-39 NGS2OYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfYNmFKSzVyPUSuO|IyPDZizszN MmrEV2FPT0WU
TI-73 NVvi[3pvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDPTWM2OD12LkiwOlA6KM7:TR?= MYrTRW5ITVJ?
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NCI-H446 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO4OFdKSzVyPUWuNlAxODlizszN NVPPdllNW0GQR1XS
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BT-20 MnnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3NTWM2OD13LkKxN|U{KM7:TR?= NYexVnFjW0GQR1XS
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CAL-27 NUH0UG14T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHSTWM2OD13LkS2N|M6KM7:TR?= NHrrZWdUSU6JRWK=
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TE-12 NY[4[4VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzOOHNyUUN3ME22Mlg{QDF5IN88US=> NF;scZBUSU6JRWK=
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SW1463 NIHH[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDHTWM2OD15LkGxNVY5KM7:TR?= MY\TRW5ITVJ?
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HCC1954 MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T0WmlEPTB;OD60OVExPCEQvF2= M1nVWXNCVkeHUh?=
SF126 MkfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jKfWlEPTB;OD60OVk{PiEQvF2= MYTTRW5ITVJ?
LB996-RCC M{\iWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HwUWlEPTB;OD61N|I2PyEQvF2= MWnTRW5ITVJ?
SKG-IIIa NU\RXYNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRThwNkOwOlkh|ryP NHvCeGZUSU6JRWK=
NCI-SNU-1 NXPITWxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT6TWM2OD16Lk[0OlQ{KM7:TR?= M1jwb3NCVkeHUh?=
LB771-HNC NYT0RXlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPxOW0yUUN3ME24MlY1Pjl4IN88US=> NIHqZXhUSU6JRWK=
SCC-4 NXzEcGZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnVOW9KSzVyPUiuOlgzOTlizszN MnHGV2FPT0WU
CAMA-1 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H6TWlEPTB;OD63O|E1PiEQvF2= MWnTRW5ITVJ?
D-502MG M1v1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHDTWM2OD16Lke4OlI6KM7:TR?= M2naVXNCVkeHUh?=
ESS-1 MnTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRThwOEi3NFQh|ryP Mm\FV2FPT0WU
HEC-1 M4jQU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRThwOEm4OlYh|ryP MoT6V2FPT0WU
NB10 NI\sVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XDUmlEPTB;OT6wNlIzPCEQvF2= NUC0PWFCW0GQR1XS
8505C M1jGe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzJclJ3UUN3ME25MlA1OjN{IN88US=> NV6yenc5W0GQR1XS
EFO-27 M4WyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjvdnEzUUN3ME25MlE3PDF{IN88US=> NHSzXmdUSU6JRWK=
HN NHjqd5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHxSWxKSzVyPUmuNVY3OjhizszN MUDTRW5ITVJ?
DSH1 M1e3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTlwMkC4O{DPxE1? MkX5V2FPT0WU
NBsusSR M1f0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTlwMke0NFIh|ryP NIrMXHlUSU6JRWK=
LS-123 NXrqTFhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTlwM{G3OlEh|ryP MYHTRW5ITVJ?
SHP-77 M{LLSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3VXoszUUN3ME25MlM6QTN3IN88US=> MWHTRW5ITVJ?
ACN M3HVSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3SOGtKSzVyPUmuOVMzPzdizszN MXjTRW5ITVJ?
U251 MlHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTlwNkW1OFQh|ryP NILCbHhUSU6JRWK=
A431 NYf6W5BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3HUIIzUUN3ME25MlgxOjN6IN88US=> MYTTRW5ITVJ?
5637 NUC3S5pXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi1d41KSzVyPUmuPFQ6QDRizszN M3fENHNCVkeHUh?=
MDA-MB-157 M2jWe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fOfGlEPTB;OT65Nlg4QCEQvF2= NEO0SXZUSU6JRWK=
A101D M{PxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3MNW1nUUN3ME25Mlk6QTd2IN88US=> NWHSXWp{W0GQR1XS
YKG-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nRRmlEPTB;MUCuNlAxPiEQvF2= MnHHV2FPT0WU
LAN-6 NVXWVYZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fhemlEPTB;MUCuNlE3PCEQvF2= M4HYTnNCVkeHUh?=
OVCAR-5 NWLmN|lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXUXnVKSzVyPUGwMlI1OzNizszN MUfTRW5ITVJ?
A549 NYHOOnBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTFyLkO5O|Mh|ryP Mlj2V2FPT0WU
no-11 NIH1VItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXRTWM2OD1zMD60N|U{KM7:TR?= MXvTRW5ITVJ?
SF539 MljPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDDfY5KUUN3ME2xNE46ODRzIN88US=> NXTCbWFWW0GQR1XS
A388 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7IWWFWUUN3ME2xNU4{QDl5IN88US=> NXy1[VJZW0GQR1XS
DEL M{Pke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvHepRKSzVyPUGxMlQzPCEQvF2= MXzTRW5ITVJ?
SW954 MnezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK1NXJJUUN3ME2xNU41PjZ6IN88US=> M4PVdHNCVkeHUh?=
TK10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzvco5KSzVyPUGxMlUzPzFizszN MofKV2FPT0WU
SW756 M2fRPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTFzLkWyPVQh|ryP M13USnNCVkeHUh?=
PC-3 NGDuUXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1L2cmlEPTB;MUGuOVc3PCEQvF2= NU\qNmRXW0GQR1XS
ONS-76 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTFzLk[zOkDPxE1? NXLzR41qW0GQR1XS
A427 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fwcmlEPTB;MUGuO|A6OyEQvF2= NXzrfm5JW0GQR1XS
MEG-01 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTFzLke1NFkh|ryP MmK0V2FPT0WU
BB30-HNC M3u1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nIRWlEPTB;MUGuO|k5OiEQvF2= Mkj2V2FPT0WU
NCI-H1299 NWLIVllRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7qZZZKSzVyPUGxMlgxQTNizszN MV;TRW5ITVJ?
GCT MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TH[mlEPTB;MUGuPFIzQCEQvF2= NWHBXGR1W0GQR1XS
D-247MG NHnCbYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTFzLkm2OlMh|ryP MkXSV2FPT0WU
CFPAC-1 M4HFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK1TWM2OD1zMT65O|gzKM7:TR?= NWT0UoFIW0GQR1XS
EKVX M1foemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnLflVEUUN3ME2xNk4xOzF|IN88US=> M1;aUHNCVkeHUh?=
CAL-51 NXnWTYZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTF{LkC3NVYh|ryP NED6OIxUSU6JRWK=
BB49-HNC MmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O4WWlEPTB;MUKuNVE4PyEQvF2= Mn[zV2FPT0WU
RPMI-7951 NV3kPHNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTF{LkG4OVQh|ryP MlX6V2FPT0WU
RH-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD6TWM2OD1zMj6yNVg1KM7:TR?= M4LkPXNCVkeHUh?=
BCPAP MmHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvaTWM2OD1zMj60O|Q6KM7:TR?= MnvpV2FPT0WU
GCIY MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX5flZKSzVyPUGyMlUzODlizszN MVfTRW5ITVJ?
KNS-81-FD MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTtTWM2OD1zMj61PFY6KM7:TR?= MmHuV2FPT0WU
KYSE-140 NHK1WZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7BfngxUUN3ME2xNk45PTl3IN88US=> NFi2RW1USU6JRWK=
Ca-Ski M3nRcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7uTWM2OD1zMj65NFQyKM7:TR?= NGPRW4xUSU6JRWK=
TGBC1TKB M4PDemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXrOWlKSzVyPUGyMlkyOTVizszN NWjrb443W0GQR1XS
HCC1187 NFvHd3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXDVIZGUUN3ME2xN{4yQTF{IN88US=> MmPuV2FPT0WU
SJSA-1 NUPlUHk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTF|LkKzNlch|ryP MWnTRW5ITVJ?
CTV-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEmwSotKSzVyPUGzMlM1PSEQvF2= MWrTRW5ITVJ?
WM-115 MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfvU|lFUUN3ME2xN{43PDh|IN88US=> M1fhVHNCVkeHUh?=
CHP-212 NVjIbmlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHlZ3RKSzVyPUGzMlk4OzlizszN NFLjRopUSU6JRWK=
SCC-15 NIPCfpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF|Lkm3O|Uh|ryP NV\JNFRMW0GQR1XS
BPH-1 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUCyVYtmUUN3ME2xOE4yPjZ2IN88US=> MWHTRW5ITVJ?
SW780 M1TyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnGdlZKSzVyPUG0MlUxOjVizszN MULTRW5ITVJ?
NCI-H2291 NFP5[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILwTXRKSzVyPUG0MlU5PzhizszN M{Dv[nNCVkeHUh?=
JEG-3 M1XxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M125OWlEPTB;MUSuOlMzPiEQvF2= M4jpeHNCVkeHUh?=
CAL-120 M4HNZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O1U2lEPTB;MUSuO|AzPyEQvF2= NW\Kc5dTW0GQR1XS
NCI-H23 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3qOoRKSzVyPUG0Mlc6QTdizszN NX;yV3VlW0GQR1XS
MS-1 NUXBT3ppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3UTWM2OD1zND65OlEyKM7:TR?= M4m5OHNCVkeHUh?=
PC-14 MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILkbGVKSzVyPUG0Mlk3PTRizszN MV7TRW5ITVJ?
D-283MED M{jJN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfDWWVvUUN3ME2xOU4xOTFzIN88US=> NGLZVVJUSU6JRWK=
OE19 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7YfllKSzVyPUG1MlE2PDFizszN M4m5OnNCVkeHUh?=
CAS-1 NVr0NGF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4m3cWlEPTB;MUWuOFE5PCEQvF2= Ml:2V2FPT0WU
NCI-H727 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX76NWJqUUN3ME2xOU41OjJzIN88US=> NVrMRm05W0GQR1XS
SiHa NEDFeY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUCzUpZqUUN3ME2xOU44PTl2IN88US=> MmX5V2FPT0WU
BFTC-905 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zl[WlEPTB;MUWuO|Y6PCEQvF2= NGDJO2FUSU6JRWK=
MDA-MB-453 NWXPfoJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D0dGlEPTB;MU[uNVY1OiEQvF2= Mn\4V2FPT0WU
HuP-T3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTF4Lk[zO|Mh|ryP Ml7BV2FPT0WU
SK-LU-1 M3\VTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7JWFVKUUN3ME2xOk43QTV4IN88US=> MWLTRW5ITVJ?
Detroit562 NImzN5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;XeZhKSzVyPUG2Mlc{OThizszN NVrP[2p{W0GQR1XS
HCC1569 NVLD[YRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13GTmlEPTB;MU[uPFM{PyEQvF2= NGDLUGdUSU6JRWK=
SK-MES-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXWNnRKSzVyPUG2Mlg1OTlizszN MUnTRW5ITVJ?
BB65-RCC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTF5LkC0O|kh|ryP M4PTXXNCVkeHUh?=
LOXIMVI NIPsZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjI[4hKSzVyPUG3MlA4ODdizszN NYn2V45JW0GQR1XS
SW1783 NF30SpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGi5PIVKSzVyPUG3MlEzQCEQvF2= NFHWV|BUSU6JRWK=
NH-12 NX\pVHJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\wT4VKSzVyPUG3MlM{ODNizszN NVv5UIllW0GQR1XS
UACC-257 NV;SdHdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF5LkW1NVIh|ryP NFHENXZUSU6JRWK=
KOSC-2 MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXhNIpiUUN3ME2xO{43PzV5IN88US=> NEH1XHpUSU6JRWK=
KG-1 NXLKPXNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknXTWM2OD1zNz62PVM4KM7:TR?= MX3TRW5ITVJ?
M059J M{Lu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjrTWM2OD1zNz63NFMh|ryP MnnkV2FPT0WU
MHH-NB-11 NHP6WGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjLZlRGUUN3ME2xO{46Pjd|IN88US=> NYCwWnJWW0GQR1XS
EW-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3STWM2OD1zOD6xN|gzKM7:TR?= M1:5N3NCVkeHUh?=
CAL-85-1 M3H0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXNb5NKSzVyPUG4MlI{PTdizszN MnfMV2FPT0WU
639-V MnfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nURWlEPTB;MUiuN|M2PCEQvF2= MljSV2FPT0WU
C32 NF3wOpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfKTJNKUUN3ME2xPE41PzJ5IN88US=> NWe2W4sxW0GQR1XS
KM-H2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj6TWM2OD1zOD61NlMzKM7:TR?= NFLmVllUSU6JRWK=
A253 MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHtTWM2OD1zOD63Nlg3KM7:TR?= MkPtV2FPT0WU
NCI-N87 NGO3fpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrNUW9tUUN3ME2xPE46ODB6IN88US=> NUTzeppXW0GQR1XS
8-MG-BA NYTmdFZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fnSGlEPTB;MUmuNFY1PiEQvF2= NGXGOFVUSU6JRWK=
GI-ME-N NWi0fmpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvzNYo6UUN3ME2xPU4yPTR4IN88US=> M1LJXXNCVkeHUh?=
8305C MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT6Z29CUUN3ME2xPU4zOjh4IN88US=> MYLTRW5ITVJ?
TE-8 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHsfIpmUUN3ME2xPU4{ODJ2IN88US=> NVTCZ2J{W0GQR1XS
KYSE-270 M3zkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[3NWlQUUN3ME2yNE4xOjF5IN88US=> MUHTRW5ITVJ?
HL-60 M3HZRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfHe5QzUUN3ME2yNE4xQTRzIN88US=> MonBV2FPT0WU
Mo-T M3fZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O0cWlEPTB;MkCuNVY3PSEQvF2= MX7TRW5ITVJ?
NCI-H1355 NFvkRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XDZmlEPTB;MkCuN|M4PCEQvF2= M3\uTHNCVkeHUh?=
HT-1080 MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LOcGlEPTB;MkCuOVQ6PyEQvF2= MlPsV2FPT0WU
MIA-PaCa-2 NHfNUWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTJyLk[4PFMh|ryP MV\TRW5ITVJ?
NCI-H441 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPrZphKSzVyPUKwMlc{PzlizszN NFmyZWlUSU6JRWK=
LCLC-97TM1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXKXW03UUN3ME2yNE45OTN2IN88US=> MYfTRW5ITVJ?
HT-3 M3PNbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\yUmpKSzVyPUKxMlU3OzFizszN M{jkPHNCVkeHUh?=
22RV1 NXfsWlhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHftfmpKSzVyPUKxMlU3QDVizszN NH72W5NUSU6JRWK=
LK-2 MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\QNWlEPTB;MkGuOVk2OyEQvF2= MlXvV2FPT0WU
CW-2 NUDhW4J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33K[mlEPTB;MkGuOlA3QSEQvF2= NHPIeI5USU6JRWK=
KYSE-510 NILpXnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:4TWM2OD1{MT62NFk2KM7:TR?= NVzlcpIyW0GQR1XS
CGTH-W-1 MofpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvoUFlCUUN3ME2yNU44OTZ4IN88US=> MmfQV2FPT0WU
NCI-H661 NX7P[mE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLTPZJLUUN3ME2yNk4xOzRizszN M33TdXNCVkeHUh?=
KU-19-19 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG5S4djUUN3ME2yNk4yPjl5IN88US=> MUTTRW5ITVJ?
NCI-H2122 NWm4dY5HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzh[lZKSzVyPUKyMlI1OzJizszN NULBSIxHW0GQR1XS
NCI-H526 NFj0ZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzHdoJ[UUN3ME2yNk4{QDl3IN88US=> M3zIfHNCVkeHUh?=
NCI-H1650 MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXkTWM2OD1{Mj63OlQh|ryP M{fyWnNCVkeHUh?=
AM-38 M2PjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjQXZhSUUN3ME2yNk45Pjh7IN88US=> MkXTV2FPT0WU
NCI-H2405 M3i2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7jTWM2OD1{Mz6yOVM{KM7:TR?= NG[2d3ZUSU6JRWK=
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NCI-H1581 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TD[mlEPTB;OEWuOFY1OSEQvF2= NIXrc4dUSU6JRWK=
KARPAS-299 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTh4LkG5O|ch|ryP MUXTRW5ITVJ?
IST-MEL1 NYrOO3RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq0[GVWUUN3ME24Ok45QDd{IN88US=> MVTTRW5ITVJ?
KP-N-YS M{PIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTh7LkmwNlgh|ryP M{PiUHNCVkeHUh?=
KYSE-410 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTaTWM2OD17MT60NFQzKM7:TR?= MnXGV2FPT0WU
TE-10 M3fEdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvtSVBKSzVyPUmxMlU3OTFizszN NXfLNXl6W0GQR1XS
SK-MEL-1 M4HKemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPuUJFKSzVyPUmyMlkyODZizszN MnjtV2FPT0WU
COLO-792 MmXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDSTWM2OD17NT6yOVY1KM7:TR?= MnPuV2FPT0WU
SCH NVXVXW1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTl4LkO4O|ch|ryP NVW1S3NjW0GQR1XS
NCI-H1792 M1e1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rrW2lEPTB;OU[uPFk6OiEQvF2= NIfHd2FUSU6JRWK=
NCI-H2029 NV;2WmNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PjdmlEPTB;OU[uPVU3PiEQvF2= NVHTe253W0GQR1XS
SW684 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nTWGlEPTB;OUiuOlY2PCEQvF2= NGXWc45USU6JRWK=
NCI-H209 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTFyMD6xNlEh|ryP NIn0W4pUSU6JRWK=
HLE M3GxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\VUFFKSzVyPUGwOU4zQDJizszN M1jYWnNCVkeHUh?=
GOTO MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvuTWM2OD1zMEeuO|c4KM7:TR?= NWD0WllbW0GQR1XS
NCI-H1793 MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjMS2F[UUN3ME2xNFkvOjhizszN M4Pzd3NCVkeHUh?=
D-392MG Mke1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHKSGZDUUN3ME2xNVcvOzl6IN88US=> M4f1SXNCVkeHUh?=
SW1990 NYTQeJppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnyeG9VUUN3ME2xNlAvQTVzIN88US=> NYXzPGhCW0GQR1XS
ML-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF{MT62O|Yh|ryP M3vKWnNCVkeHUh?=
NCI-H2452 NXqzbWE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDrcmVTUUN3ME2xNlIvOjFizszN NFuxeWlUSU6JRWK=
SK-MEL-30 MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF{Mz6yOFQh|ryP Ml3rV2FPT0WU
SN12C MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTF{ND6xO|Yh|ryP MYfTRW5ITVJ?
NCI-H1770 NUn3OG56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\4fWlEPTB;MUK1MlUyPCEQvF2= MVvTRW5ITVJ?
SF268 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\2TWM2OD1zMk[uNVU5KM7:TR?= MVXTRW5ITVJ?
BALL-1 M2fweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnRNXBwUUN3ME2xNlYvOjNizszN NEjSbpZUSU6JRWK=
COLO-679 NUHaPHppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3hTWM2OD1zMk[uO|U{KM7:TR?= M37l[3NCVkeHUh?=
A2780 M2Wzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF{OD65PFgh|ryP MY\TRW5ITVJ?
NCI-H1651 NUTjOHBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S3eGlEPTB;MUOxMlI1OyEQvF2= Mn;oV2FPT0WU
NCI-H2087 NXvYUJhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq5b|NWUUN3ME2xN|EvPDh|IN88US=> M1nENHNCVkeHUh?=
U-87-MG NXzmOFRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfmeVNKSzVyPUGzN{43ODRizszN MXvTRW5ITVJ?
LB2518-MEL MmCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTF|NT65PVMh|ryP MVrTRW5ITVJ?
HCT-116 NH\xfGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTF|Nz6yNVch|ryP MlLiV2FPT0WU
Ca9-22 NVTxbIQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrZc3Y5UUN3ME2xN|kvQDN|IN88US=> MonzV2FPT0WU
COR-L88 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rhbWlEPTB;MUSyMlE1KM7:TR?= MVTTRW5ITVJ?
CP50-MEL-B MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTF2ND61NFEh|ryP M3XDZ3NCVkeHUh?=
OVCAR-8 NYH1fZdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\XTWM2OD1zNEWuOlM3KM7:TR?= NWnKO|M4W0GQR1XS
SK-MEL-3 NHrUNHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf5c2RKSzVyPUG0O{45PzhizszN Ml73V2FPT0WU
GT3TKB NX24VGZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF2OT65Nlgh|ryP MmnjV2FPT0WU
KYSE-450 M1XVNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nsPWlEPTB;MUWxMlU{QSEQvF2= NGjpXHdUSU6JRWK=
CAPAN-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M333[GlEPTB;MUWzMlA3PCEQvF2= NGP6bm9USU6JRWK=
BEN NX7MZYtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXxVIVKSzVyPUG1N{46OjhizszN M{OyN3NCVkeHUh?=
NCI-H1304 M{jZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrXTWM2OD1zNUSuOlk1KM7:TR?= NHHlN2RUSU6JRWK=
KU812 NFvWWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF3OD62O|Qh|ryP NEC5b3pUSU6JRWK=
Capan-2 NHXxPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnVVHdKSzVyPUG2NE42PTNizszN MoPyV2FPT0WU
A673 NFrUW|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHOT4FZUUN3ME2xOlEvPzB3IN88US=> NECwRXdUSU6JRWK=
SAS NIDLPXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlSzTWM2OD1zNkKuOlc5KM7:TR?= NHL6ZZlUSU6JRWK=
NY NULKVlR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTF4NT6zNVQh|ryP M4O5e3NCVkeHUh?=
HCE-4 NX;nd2RpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfwVFZKSzVyPUG2Ok45PDVizszN MnHVV2FPT0WU
MDA-MB-231 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm1TWM2OD1zN{euOVA{KM7:TR?= M4PGXHNCVkeHUh?=
no-10 M{TIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz4SppKSzVyPUG3PE4yOzRizszN NFfhRZNUSU6JRWK=
MZ7-mel MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFryUoJKSzVyPUG3PE41PjdizszN M2[wd3NCVkeHUh?=
NCI-H82 NEH3SIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H2[mlEPTB;MUiwMlE3PSEQvF2= MVfTRW5ITVJ?
CAL-72 MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfXTWM2OD1zOEWuNFU1KM7:TR?= MXjTRW5ITVJ?
NCI-SNU-5 NUjDdnBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknTTWM2OD1zOE[uPFQh|ryP NXrIVGJnW0GQR1XS
OVCAR-4 NEPPW2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fKWGlEPTB;MUi4MlM{OyEQvF2= MYXTRW5ITVJ?
SCC-9 Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jJZmlEPTB;MUmxJO69VQ>? NGTxelhUSU6JRWK=
KYSE-150 NFS5S5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\3TWM2OD1zOUGuPFg5KM7:TR?= MX;TRW5ITVJ?
HT-29 NVfwc3g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3Wfnp{UUN3ME2yNFEvOjF{IN88US=> MnLqV2FPT0WU
COLO-678 NU\TOo1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T0b2lEPTB;MkCxMlQ2KM7:TR?= NX;FPFJnW0GQR1XS
NCI-H650 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HxUGlEPTB;MkCyMlExOyEQvF2= NVHPclZ3W0GQR1XS
HuCCT1 NWnibmpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\VTWM2OD1{MESuNlA5KM7:TR?= NVPMV4lNW0GQR1XS
SW1116 NFf6PGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnHXHVMUUN3ME2yNFcvODd5IN88US=> NXTPd3Q1W0GQR1XS
DBTRG-05MG NX6wVIZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[xTWM2OD1{MEeuPVA6KM7:TR?= NEHkeJFUSU6JRWK=
SW982 M17JTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrDTWM2OD1{MEeuPVQ5KM7:TR?= Mom2V2FPT0WU
RCM-1 M3Tv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnG2TWM2OD1{MUSuO|YzKM7:TR?= NETWTZFUSU6JRWK=
COLO-320-HSR NVLqSYhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Lh[2lEPTB;MkG2MlEzPSEQvF2= Mn;VV2FPT0WU
KNS-42 NEH3folIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NISxO|NKSzVyPUKxOk42PzRizszN NYnmR5ViW0GQR1XS
C2BBe1 NHPLU5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJ|MT65NFUh|ryP NUfZeYNTW0GQR1XS
CCRF-CEM MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLme5VoUUN3ME2yOFMvPzl3IN88US=> NH31b41USU6JRWK=
SH-4 M2LXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;OTWM2OD1{NE[uNFkh|ryP NF31VmNUSU6JRWK=
LS-1034 M2rO[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HLe2lEPTB;MkS2MlI3PiEQvF2= NF;ZXGtUSU6JRWK=
NCI-H2347 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXY[lZKSzVyPUK0O{44OTNizszN MnHYV2FPT0WU
RPMI-8866 MmjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jiUGlEPTB;MkS5MlI4KM7:TR?= NVjlTJlCW0GQR1XS
GAK MknNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJ3Mz6wNFIh|ryP NYfD[nloW0GQR1XS
NB6 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nhTGlEPTB;MkewMlEh|ryP NIfKV2pUSU6JRWK=
COLO-680N NXyyPHk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjDOmNKSzVyPUK3Nk42OjdizszN NInReHlUSU6JRWK=
RERF-LC-MS M1jNXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETLXG5KSzVyPUK3Ok4xODdizszN NYiyTotOW0GQR1XS
TGBC11TKB MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fiXWlEPTB;Mke4MlE4QCEQvF2= NF;1R2NUSU6JRWK=
C8166 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33IOWlEPTB;Mke4MlUxPiEQvF2= MnvCV2FPT0WU
HDLM-2 M1\1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPSWW84UUN3ME2yPVQvPDB7IN88US=> M3K1eXNCVkeHUh?=
IGR-1 NHS2OJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TldmlEPTB;Mkm1MlY2QSEQvF2= NXfQdWJNW0GQR1XS
FADU MmjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJ7Nz61NUDPxE1? MVHTRW5ITVJ?
L-428 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ7Nz62NVYh|ryP MV3TRW5ITVJ?
LU-65 MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTNyND6zNkDPxE1? NWTTNHFoW0GQR1XS
HEL Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PpUGlEPTB;M{C5Mlk5OyEQvF2= NGnNeFBUSU6JRWK=
NCI-H810 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHlNmxKSzVyPUOxNE42PyEQvF2= M4DodXNCVkeHUh?=
C3A MlPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{K4TWlEPTB;M{GxMlgxOiEQvF2= Mmq4V2FPT0WU
NCI-H630 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXIXppxUUN3ME2zN|IvOjl2IN88US=> NGLqRYhUSU6JRWK=
KP-N-YN NXfJRoY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq4SWxKSzVyPUO0NU4yOjNizszN MYnTRW5ITVJ?
MOLT-13 M{fIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K4T2lEPTB;M{SyMlMzPiEQvF2= MoTPV2FPT0WU
NCI-H1993 M3TWU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\IWmVKSzVyPUO0Nk4{PjVizszN NUfzO5p1W0GQR1XS
BE-13 NGTqfJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDxNYZsUUN3ME2zOFQvOTZ5IN88US=> M2T4SXNCVkeHUh?=
IST-SL1 NUfBbWNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7PTWM2OD1|NEeuOFAyKM7:TR?= M4r0NXNCVkeHUh?=
TE-9 M3fwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1f3TGlEPTB;M{[zMlU5QSEQvF2= Mnv2V2FPT0WU
LU-135 M{TCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTN4Nz6wN|Uh|ryP M4i0SnNCVkeHUh?=
T84 MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jYW2lEPTB;M{e0MlcyOiEQvF2= MXXTRW5ITVJ?
K-562 MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nwOmlEPTB;M{izMlM3KM7:TR?= M3fOeHNCVkeHUh?=
SBC-5 MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHxXHdKSzVyPUO4Ok46QDVizszN MWXTRW5ITVJ?
NB17 NGjmOmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:yVmlEPTB;M{myMlU6PiEQvF2= MXjTRW5ITVJ?
NCI-H2052 NUTWTVZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXq[HZKSzVyPUO5PE41PzJizszN M{TTcnNCVkeHUh?=
HCC38 NEf5[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjlTWM2OD12MEGuOVk{KM7:TR?= M3PVeXNCVkeHUh?=
NCI-H69 NGWzR4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTR2MT6wPFMh|ryP NHW3c2FUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

カスタマーフィードバック (18)


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Source , , Cell, 2015, 160(1-2): 161-76 . MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines Ser78 cells
Concentrations 5 µM
Incubation Time 1 h
Results Two selective AKT inhibitors MK-2206 and GDC-0068, both significantly reduced MKK4 phosphorylation on Ser78 in axons after injury.

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Source Cancer Cell, 2013, 24, 766-76. MK-2206 2HCl purchased from Selleck
Method analysis of luciferase activity
Cell Lines immunodeficient NOG mice
Concentrations 10 mg kg-1
Incubation Time 3 days
Results In this experiment, animalstreated with dexamethasone or MK2206 showed progressivetumor growth similar to that observed in vehicle-treated controls,while mice treated with MK2206 plus dexamethasone had significant antitumor responses.

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Source Cancer Discov, 2012, 2, 934-47. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines PC9GR4/WZR10 cells
Concentrations 1 uM
Incubation Time 72 h
Results The addition of a dual PI3K and MTOR inhibitor, PI103, or the AKT inhibitor MK-2206, did reduce the expression of pAKT neither in GR4 cells nor WZR10 cells.

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Source J Exp Med, 2014, 211(9), 1741-58. MK-2206 2HCl purchased from Selleck
Method 3D migration model
Cell Lines WT or Rap1b-/- neutrophil
Concentrations 2 uM
Incubation Time
Results MK-2206 treatment completely reversed elevated TEM across mouse endothelial cells of Rap1b-/- neutrophils to WT levels (A). It reduced ECM degradation of Rap1b -/- neutrophils, and inhibited their multiple protrusions (B and C). Furthermore, almost all Rap1b -/- cells treated with MK-2206 were found at the endothelial cell junctions (D).

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Source Nat Commun, 2015, 6:6943. MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines HUVECs
Concentrations 1 uM
Incubation Time 8 h
Results Because YAP is also a known substrate of Akt21, we examined whether blockade of the Akt pathway affects YAP phosphorylation. Both Ly294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and MK-2206, an allosteric inhibitor of Akt, suppressed cell contact-mediated YAP phosphorylation.

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Source Leukemia, 2015, 29(1), 169-76. MK-2206 2HCl purchased from Selleck
Method Immunoblotting
Cell Lines CXCR4S338X-expressing BCWM.1 cells
Concentrations 0.5 uM
Incubation Time 6 h
Results As AKT and ERK, but not BTK, show continued SDF-1a-triggered activation in CXCR4S338X-expressing WM cells treated with ibrutinib, we next sought to clarify if AKT and ERK contributed to the enhanced survival of these cells. It therefore treated SDF-1acultured CXCR4S338X BCWM.1 cells with either AKT- (MK-2206 and AZD-5363) or MEK- (AS-703026, AZD-6244 and UO126) specific inhibitors with and without ibrutinib (0.5 uM) for 6 h so as to clarify the contribution of AKT and ERK to ibrutinib resistance. The inhibitory activity of MK-2206, as well as AS-703026, AZD-6244 and UO126 was confirmed by western blot analysis for pAKT (S473) and pERK (T202/Y204), respectively.

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Source Cancer Res, 2013, 73, 2189-98. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines SKNAS/SJNB8/IMR32/GIMEN/SHEP2/KCNR/NGP/LAN1/LAN5/TR14/UHGNP cell lines
Concentrations 8 μM
Incubation Time 48 h
Results The 8 μM MK-2206 treatments resulted in effective pathway inhibition in all cell lines as shown by western blot for phosphoryl ated FOXO3a and PRAS40 as well as AKT serine 473 phosphorylation.

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Source Oncotarget, 2011, 2, 1109-26. MK-2206 2HCl purchased from Selleck
Method Western blot/ Wst-1 assay
Cell Lines ATC/ FTC cell lines
Concentrations 500 nM
Incubation Time 1 h/72 h
Results One-hour treatment with the AKT inhibitor MK-2206 (0.5 μM) or with the MEK inhibitor U0126 (10 μM) effectively abolished AKT and ERK1/2 phosphorylation in all cell lines.

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Source Sci Signal, 2011, 4, rs9. MK-2206 2HCl purchased from Selleck
Method ELISA
Cell Lines HeLa cells
Concentrations 1 μM
Incubation Time
Results Treatment of infected cells with kinase inhibitors directed at Akt (MK-2206), MEK(PD 98059), PKC(CEC), or Pim family kinases identified a dominant role for Pim family kinases in the release of IL-8 from Salmonella-infected epithelial cells.

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Source FASEB J, 2013, 27, 1644-56. MK-2206 2HCl purchased from Selleck
Method Clonogenic growth assay
Cell Lines U2OS cells
Concentrations 1 μM
Incubation Time 9 d
Results Specific inhibition of PKB activity using MK-2206 or triciribine also significantly reduced cell growth, although to a lesser extent compared to PI-103, suggesting that both the PKB and mTOR pathways are important for anchorage-dependent growth.

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Source Gynecol Oncol, 2011, 123, 13-8. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines ovarian cancer cell lines
Concentrations 1-6 μM
Incubation Time 1 h/72 h
Results Activation of pAKT by IGF-1 in the low-grade cell line HOC-7 was blocked by the AKT inhibitor MK-2206.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Confocal microscopy
Cell Lines platelets
Concentrations 1μM
Incubation Time
Results Upon treatment with increasing concentrations of AEA from 0.1 to 10 mM (Fig. B–D) platelets were fully fluorescently marked as compared to control (Fig. A) and the increase in DAF 2 fluorescence intensity appears to be dose-dependent. In agreement with data shown in Figure 4, SR1(Fig. E) and MK2206 (Fig. F) abolished fluorescence intensity induced by AEA, while LY294002 (Fig. 5G) was less potent.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines platelets
Concentrations 1 μM
Incubation Time
Results eNOSser1177 phosphorylation was greatly reduced by LY294002 and cancelled by MK2206 but it was not modified by platelet pretreatment with EGTA or BAPTA/AM.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Nitriter+Nitrate(NOX) measurement, cGMP detection
Cell Lines platelets
Concentrations 1 μM
Incubation Time 1 min
Results As shown in Figure 4 SR1 significantly reduced both NOx and cGMP formation, while SR2 failed to affect these parameters.

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Source Radiat Oncol, 2009, 4, 43. MK-2206 2HCl purchased from Selleck
Method Western blot, clonogenic survival assay
Cell Lines U87MG cells
Concentrations 1 μM
Incubation Time 1 h
Results Akt inhibitor MK-2206 showed similar effect. MK-2206 is a potent allosteric Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3 respectively. U87MG cells were preincubated with 1 μM MK-2206 for 1 hr, followed by irradiation at 0 - 9 Gy. As shown in Fig C, MK-2206 treatment abolished IR-induced Akt phosphorylation. Moreover, treatment with MK-2206 also increased the radiosensitivity of U87MGcells (Fig. D)

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Source Dr. Zhang of Tianjin Medical University. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines Breast cancer cells
Concentrations 0-10 nM
Incubation Time 3 h
Results Breast cancer cells were serum starved for 24 h, pretreated with the indicated concentrations of MK-2206 for 3 h, and then treated with 100ng/ml EGF for 15 min.

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Source Biochim Biophys Acta, 2012, 1823, 987-96. MK-2206 2HCl purchased from Selleck
Method Immunofluorescence
Cell Lines HC11 cells
Concentrations 10 µM
Incubation Time 1 h
Results whole ADRP levels, estimated by Western blot , decreased only in the presence of MK -2206 and LY294002. In most cases, ADRP decorated the surface of small lipid droplets and appeared as little patches on large cytoplasmic lipid droplets. With the exception of SP600125, which induced a strong ADRP coating of almost all cytoplasmic lipid droplets (although this inhibitor did not increase ADRP synthesis), variation in the distribution of ADRP at the surface of lipid droplet was difficult to estimate, notably because the signal was faint and uneven.

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Source MK-2206 2HCl purchased from Selleck
Method Western blot analysis
Cell Lines MCF-7 cells
Concentrations 0 nM/100 nM/250 nM/1000 nM
Incubation Time 24 h
Results The effect of MK-2206 on the serine 473 phosphorylation mark of AKT 1 was uneven and did not correlate with inhibition of AKT activity, but the AKT1 mutant cells maintained higher levels of AKT1 serine 473 phosphorylation with increasing concentrations of MK-2206. Of note, MK-2206 completely inhibited AKT2 activation at 100 nM, a concentration where PIK3CA E545K mutant, but not AKT1 mutant cells were already strongly growth inhibited. MK-2206 treatment up to 1 μM did not have strong effects on other protein biomarkers such as ribosomal protein S6, ev en though growth was suppressed by approximately 80% in MCF-7 cells at this concentration.

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