MK-2206 2HCl

MK-2206 2HCl は一種の高選択性のAkt1/2/3阻害剤で、無細胞試験でIC50値が8 nM/12 nM/65 nMそれぞれに分かれて、250種類他のタンパク質キナーゼに抑制活性を表しません。臨床2期。

価格 在庫  
USD 138 あり
USD 214 あり
USD 277 あり
USD 466 あり
USD 718 あり

MK-2206 2HCl 化学構造
分子量: 480.39

高品質保証

文献中の引用(180)

カスタマーフィードバック(19)

MSDS

製品説明

  • Compare Akt Inhibitors
    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HCl は一種の高選択性のAkt1/2/3阻害剤で、無細胞試験でIC50値が8 nM/12 nM/65 nMそれぞれに分かれて、250種類他のタンパク質キナーゼに抑制活性を表しません。臨床2期。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 MWnDfZRwfG:6aXOgRZN{[Xl? MkjPN{DPxE1? NX;FPYFVPzJiaB?= NEH6PHRFVVOR NGLuVXBKdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbh?= M{PielIxPTdzME[5
A431 NF\MT5pMcW6jc3WgRZN{[Xl? M4LLZVUh|ryP NXzERpV3PSCq NVfTRm1jTE2VTx?= M1nkS3N2eHC{ZYPz[ZMhfGinIIPp[45idGmwZzDv[kBCc3RiYX7kJGVzcw>? NXL3bnBFOjB3N{GwOlk>
HepG2 MnvLR5l1d3SxeHnjJGF{e2G7 NEPVPWkyOCEQvF2= MkH0NlQhcA>? MWfEUXNQ NFixNo5U\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> MU[yNVIxPTl{NR?=
Sk-Hep1 MXLDfZRwfG:6aXOgRZN{[Xl? NGXyZpAyOCEQvF2= Mlv2NlQhcA>? MWHEUXNQ M1H2[nNmdnOrdHn6[ZMhemW|aYP0ZY51KGOnbHzzJJRwKHSqZTDjfZRwfG:6aXOg[YZn\WO2IH;mJJNwemGoZX7pZi=> NFi4d|QzOTJyNUmyOS=>
OCUT1 cells harbored PIK3CA (H1047R+/+) NFHZT|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP6N{DPxE1? NEDJNpU2KGR? NH\XbYFFVVOR NHHQPIpKSzVyPUCuNVQh|ryP MVSyNVI5QTJ4Nx?=
K1 cells harbored PIK3CA (E542K+/+) MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIizUW4{KM7:TR?= NXL0PHIzPSCm NHHBZmpFVVOR NEjEemRKSzVyPUCuOVIh|ryP NWi5VHF[OjF{OEmyOlc>
FTC133 cells harbored PTEN (allele deletion and R130+) MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3yN{DPxE1? MnP2OUBl MWHEUXNQ NVfnUnNRUUN3ME2wMlE5KM7:TR?= NYXh[WJ2OjF{OEmyOlc>
C643 cells harbored HRAS (G13R+/−) M1XrTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mni2N{DPxE1? MYe1JIQ> NUTsS5luTE2VTx?= NESyd4JKSzVyPUCuNlch|ryP MnHKNlEzQDl{Nke=
Hth7 cells harbored NRAS (Q61R+/−) M3q3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYWzJO69VQ>? M2fkOlUh\A>? NXrZbItqTE2VTx?= NF7GWHdKSzVyPUSuOUDPxE1? Mmi3NlEzQDl{Nke=
TPC1 cells harbored RET/PTC1 rearrangement NGHoWY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zNXVMh|ryP NYjXRnNWPSCm NGTOSZdFVVOR MmiyTWM2OD1yLkW5JO69VQ>? MU[yNVI5QTJ4Nx?=
Hth74 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYGzJO69VQ>? M3Tn[VUh\A>? NEjTXIdFVVOR NF\X[3ZKSzVyPUKuNVkh|ryP NWDLU|RmOjF{OEmyOlc>
KAT18 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX:zJO69VQ>? NEHic4k2KGR? MWHEUXNQ MYPJR|UxRTRwNkKg{txO NWD3SmRjOjF{OEmyOlc>
SW1736 M33J[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnqN2YyODBizszN NHywS202KGR? MVfEUXNQ NVjpelZOUUN3ME20O{42PiEQvF2= MUCyNVI5QTJ4Nx?=
WRO MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrjPJAyODByIN88US=> NIi5dWM2KGR? NHLzOY1FVVOR MlPMTWM2OD5zMECwJO69VQ>? MkTNNlEzQDl{Nke=
TAD2 NFfJcHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3WzWFExODBizszN NHnMN202KGR? M4LNZWROW09? NHXOSGpKSzVyPkGwNFAh|ryP MknwNlEzQDl{Nke=
LN229 M2L1eWFxd3C2b4Ppd{BCe3OjeR?= MV:wMlUh|ryP NYXhWpZPPjBiaB?= NXXkRW1ETE2VTx?= M4fHc2F2\22nboTzJIFxd3C2b3flcolkKGWoZnXjeJMhd2ZiZ3XmbZRqdmmk NVfYe3FmOjJyNUe5NVQ>
T98G MofoRZBweHSxc3nzJGF{e2G7 MU[wMlUh|ryP NHL0bHU3OCCq M3fTU2ROW09? MoS3RZVodWWwdIOgZZBweHSxZ3XubYMh\W[oZXP0d{Bw\iCpZX\peIlvcWJ? NXPRVYpWOjJyNUe5NVQ>
HC11 NUX2SlNbTnWwY4Tpc44hSXO|YYm= MWWxNEDPxE1? NV7DO3VqOjRiaB?= NIDZ[4JFVVOR MUDJcohq[mm2czFOtk1k[XOnaX6gZY5lKEGGUmCgd5lvfGinc3nz M4DrNFIzPDJ4NkKx
MOLT-4 MlTHR5l1d3SxeHnjJGF{e2G7 MVWxNEDPxE1? Ml7sOFghcA>? MYHEUXNQ NYi0TWppUUN3ME2xMlfjiIoQvF2= MXuyNlYyPDJ2Mx?=
CEM-R MoXOR5l1d3SxeHnjJGF{e2G7 MVuxNEDPxE1? MXG0PEBp NULHb4Z[TE2VTx?= M1fKcGlEPTB;Mz6z5qCK|ryP MkC2NlI3OTR{NEO=
CEM-S M1O3VWN6fG:2b4jpZ{BCe3OjeR?= MkfPNVAh|ryP NEnqZ3M1QCCq MkTxSG1UVw>? M1HSO2lEPTB;NT6x5qCK|ryP MVqyNlYyPDJ2Mx?=
MOLT-4 MV7GeY5kfGmxbjDBd5NigQ>? MV:xNEDPxE1? MV2yOEBp MlHQSG1UVw>? NFG3ZnhDdG:la4OgZ4VtdHNiaX6geIhmKEdyL1exJJBp[XOnIH;mJJRp\SClZXzsJIN6[2yn NYDid|EyOjJ4MUSyOFM>
MOLT-4 Ml7QSpVv[3Srb36gRZN{[Xl? MUe05qCK|ryP NE\PbHI1KGh? MVfEUXNQ MoTiTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{PBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz MXyyNlYyPDJ2Mx?=
CEM-R M2rDTmZ2dmO2aX;uJGF{e2G7 M4DTblTjiIoQvF2= M3;yWFQhcA>? NXPpc|RoTE2VTx?= NEjlbmlKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDOGEwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? MXyyNlYyPDJ2Mx?=
CEM-S M3jZV2Z2dmO2aX;uJGF{e2G7 MorKOQKBkc7:TR?= MlrVOEBp NFezNJdFVVOR M4mweWlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFO1RU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? M3PpelIzPjF2MkSz
HepG2 cell NX7STIVKU2mwYYPlJGF{e2G7 NV;ETpFFOjBizszN MWeyOEBp NITtTmZFVVOR M1fyS2Rwf26{ZXf1cIF1\XNidHjlJJBpd3OyaH;yfYxifGmxbjDv[kBCU1R? Mni0NlM4QTd|MUm=
HepG2 cell MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG0PYVxOzBizszN MXqyOEBp MnrVSG1UVw>? M3;kUWlvcGmkaYTzJINmdGxiZ4Lve5Rp MnX4NlM4QTd|MUm=
HepG2 cell M3fHT2Fxd3C2b4Ppd{BCe3OjeR?= MX:yNEDPxE1? NVPiRowxOjRiaB?= NEGzU3dFVVOR NIDuXHZKdmS3Y3XzJINmdGxiYYDvdJRwe2m| MX2yN|c6PzNzOR?=
GEO MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXW1NFAhdk1? M3n6cFczKGh? MVrEUXNQ M{ft[WlvcGmkaYTzJINmdGxiZ4Lve5Rp MlTQNlQ2QDF{M{G=
CNE-1 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHDeXl5OTBizszN M3TNd|k3KGh? NFP0e3ZFVVOR NUTNT|NlUUN3ME2yMlk3KM7:TR?= MkD3NlU{OzZ7MkW=
CNE-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f4dlExKM7:TR?= MW[5OkBp NEjhPGhFVVOR Mmn4TWM2OD12LkWzJO69VQ>? NF7udVAzPTN|NkmyOS=>
HONE-1 NVe4UHpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXOxNEDPxE1? MVq5OkBp NVTxNFlTTE2VTx?= MV\JR|UxRTNwM{eg{txO MYmyOVM{Pjl{NR?=
SUNE-1 NXm3UWZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUOxNEDPxE1? NYizTHhMQTZiaB?= M4KwUGROW09? MVLJR|UxRTBwNUKg{txO NVzNZ4VqOjV|M{[5NlU>
CNE-2 NGTafWpHfW6ldHnvckBCe3OjeR?= MUOxNEDPxE1? MYm0PEBp MUjEUXNQ MWXJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy NV7zW4g2OjV|M{[5NlU>
HONE-1 MmnHSpVv[3Srb36gRZN{[Xl? MlPCNVAh|ryP NHjJeWQ1QCCq NUPPRpJ{TE2VTx?= M{nXUmlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhTzF? NUXFNXV1OjV|M{[5NlU>
NEC8 NEnDOWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX0c|R2UUN3ME2wMlA6PjVzIN88US=> MojjV2FPT0WU
P12-ICHIKAWA Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMUG2NkDPxE1? NIrQdo1USU6JRWK=
MDA-MB-175-VII M{HsTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMUO3N|gh|ryP MlqzV2FPT0WU
AsPC-1 NV3CdI51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWi3bHhqUUN3ME2wMlIzOTJ{IN88US=> M1LwSHNCVkeHUh?=
T47D NYHDZYtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;PNodsUUN3ME2wMlI5OjVizszN NYTDfYdCW0GQR1XS
HH NVjzSWhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXKSJpKSzVyPUCuN|AzQDNizszN MUTTRW5ITVJ?
MOLT-16 MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD5WJgzUUN3ME2wMlMxOzJizszN NIrz[5hUSU6JRWK=
ES5 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwM{S0OVUh|ryP M37CVHNCVkeHUh?=
RS4-11 NH21bWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3THbGlEPTB;MD6zOFYyKM7:TR?= NXXQPVBlW0GQR1XS
KARPAS-45 NXWxdYZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3zd3BGUUN3ME2wMlM4OzJzIN88US=> MXfTRW5ITVJ?
NCI-H720 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnO4TWM2OD1yLkO3Olc6KM7:TR?= NGPLPZlUSU6JRWK=
H9 NHSxZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:5S5JKSzVyPUCuN|g5QDNizszN M3rCdXNCVkeHUh?=
EFM-19 M4Lzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\kTWM2OD1yLkS0NFEh|ryP MU\TRW5ITVJ?
SBC-1 NEHwcoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\qUok4UUN3ME2wMlQ1ODN3IN88US=> MXfTRW5ITVJ?
A4-Fuk M1no[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTzTWM2OD1yLkS2PFY5KM7:TR?= NFy1SGRUSU6JRWK=
NCI-H1563 NW\tcnFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYe0cmZrUUN3ME2wMlQ5OTh7IN88US=> M1jIfXNCVkeHUh?=
HCC1419 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHwTWM2OD1yLkS4PFkzKM7:TR?= M{ewW3NCVkeHUh?=
H-EMC-SS NFnid4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwNEm5N|kh|ryP M{nPZnNCVkeHUh?=
BHT-101 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwNUK5OlEh|ryP NHjib3JUSU6JRWK=
IGROV-1 M33TSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzQeHlzUUN3ME2wMlU2OjR7IN88US=> NXnnVlBwW0GQR1XS
HGC-27 NWDsPI1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnVOVJKSzVyPUCuOVY4QDNizszN MWHTRW5ITVJ?
MDA-MB-361 M2fpeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK4TWM2OD1yLkW3O|YyKM7:TR?= NIfJOmZUSU6JRWK=
KE-37 M1jOUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGGweGdKSzVyPUCuOVgzPiEQvF2= NU\EdHhpW0GQR1XS
HCC70 M2K4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HkcmlEPTB;MD61PVgzPyEQvF2= NULlUmVvW0GQR1XS
LNCaP-Clone-FGC M{DBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLCTWM2OD1yLk[xNFQ5KM7:TR?= NWHUc3RxW0GQR1XS
HAL-01 M4WwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17MT2lEPTB;MD62NlE{KM7:TR?= NYL1cW53W0GQR1XS
HT NGT3Z2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi5dGxKSzVyPUCuOlMzOzlizszN M4ThZXNCVkeHUh?=
MDA-MB-415 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PYNWlEPTB;MD62N|YzPiEQvF2= MWnTRW5ITVJ?
NOS-1 M37WZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGCxXYRKSzVyPUCuOlM4OjNizszN M4PUWnNCVkeHUh?=
DU-145 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXVTWM2OD1yLk[0O|Q2KM7:TR?= NWfhVFVtW0GQR1XS
OCUB-M Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPVTWM2OD1yLkewPVY3KM7:TR?= MXjTRW5ITVJ?
VA-ES-BJ M3KxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3myXmlEPTB;MD63N|AzPSEQvF2= MkLtV2FPT0WU
J-RT3-T3-5 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PWbGlEPTB;MD63OFQxOyEQvF2= NYq1flNqW0GQR1XS
MOLT-4 M334bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\3eXFKSzVyPUCuPFA2QDJizszN M{LsPHNCVkeHUh?=
NB7 NIfNTXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PaRWlEPTB;MD64NlQyOSEQvF2= NIPM[JVUSU6JRWK=
L-363 NV3QbZFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K5UmlEPTB;MD64N|Q1OiEQvF2= Mn\SV2FPT0WU
NKM-1 NEHF[W1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXpOnRVUUN3ME2wMlg3OjV|IN88US=> MVfTRW5ITVJ?
HOP-92 Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLnfFVKSzVyPUCuPFczOjNizszN NXPxWJlHW0GQR1XS
OAW-42 M{PseGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LkcGlEPTB;MD64PFczKM7:TR?= NEGzUZJUSU6JRWK=
HuO9 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwOUK3OVEh|ryP NFe1e4RUSU6JRWK=
MFE-280 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvr[nFRUUN3ME2wMlk3PDZ3IN88US=> Ml3TV2FPT0WU
EM-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwOUe5N|kh|ryP NE\JXI1USU6JRWK=
NCI-H520 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle5TWM2OD1yLkm4OVkzKM7:TR?= NWTLNm8{W0GQR1XS
LB2241-RCC NYnUcFhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXjdoZKSzVyPUCuPVk4OzRizszN NEXQU2ZUSU6JRWK=
SK-NEP-1 NULyUotST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml34TWM2OD1zLkG0OFg2KM7:TR?= M2DrUHNCVkeHUh?=
LXF-289 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfMZXZKSzVyPUGuNVcyPTZizszN NEHyPW5USU6JRWK=
EPLC-272H MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[zeGlEPTB;MT6xO|I2PiEQvF2= NGTqfXhUSU6JRWK=
COLO-684 MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e2UWlEPTB;MT6yN|czPSEQvF2= M3jyUnNCVkeHUh?=
ES1 NHzwOlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXL2XlE1UUN3ME2xMlI1ODZ3IN88US=> NFjieIlUSU6JRWK=
DOHH-2 M13FbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLOTWM2OD1zLkK4NlA{KM7:TR?= MYXTRW5ITVJ?
CTB-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHiOmJKSzVyPUGuNlg6QSEQvF2= NH:5PHZUSU6JRWK=
G-401 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\wVWlEPTB;MT6yPVc6PSEQvF2= MlvuV2FPT0WU
LoVo M2XSdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXHfW9FUUN3ME2xMlMzPTN2IN88US=> M4Dn[HNCVkeHUh?=
Ramos-2G6-4C10 NFHoOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\ITWM2OD1zLkOzO|AyKM7:TR?= MWHTRW5ITVJ?
MFM-223 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrUcIxKSzVyPUGuN|Q1PjFizszN NIDJRpVUSU6JRWK=
PA-1 MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTFwM{WyOlUh|ryP Ml7hV2FPT0WU
697 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknWTWM2OD1zLkO3OlE3KM7:TR?= M3jabHNCVkeHUh?=
QIMR-WIL NHz5TopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfEVZpKSzVyPUGuOFkyOTZizszN NWOxTVg4W0GQR1XS
HOS NUjseIpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFwNEm1OVgh|ryP MlrIV2FPT0WU
DMS-273 NE\lb5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1naVGlEPTB;MT61NVk2QSEQvF2= NGPRNW9USU6JRWK=
ME-180 NV\4[5N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDMPGJKSzVyPUGuOVY5QTFizszN NEfkT2dUSU6JRWK=
HCC2218 NXT6emF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zUWWlEPTB;MT62PFIzPSEQvF2= MknsV2FPT0WU
CAL-54 NETDPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj4PGtEUUN3ME2xMlcyOjR{IN88US=> NH\Od2NUSU6JRWK=
OMC-1 NVLIU2NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;0d5RuUUN3ME2xMlc1Pjd5IN88US=> M1zy[XNCVkeHUh?=
COR-L105 M1GxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrpZmhZUUN3ME2xMlc6PzN5IN88US=> NY\4WJc1W0GQR1XS
BV-173 NYPTXm9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFwOEGwO|Qh|ryP M{TlXHNCVkeHUh?=
RKO M1W0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTFwOEexNFEh|ryP M{DWdXNCVkeHUh?=
SNU-387 NIP5dJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLBTWM2OD1zLki4OFA3KM7:TR?= NH7CfWlUSU6JRWK=
SW1088 NX64dpYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPCb2c3UUN3ME2xMlk1PjB4IN88US=> NFPNdVhUSU6JRWK=
Hs-578-T NV\ZU4hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3ScnBKSzVyPUKuNVE1OzNizszN NWXBeZZ7W0GQR1XS
OC-314 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJwMUWwPFYh|ryP NFjYSoxUSU6JRWK=
RMG-I NVHMT2JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TmdGlEPTB;Mj6xOlM6QCEQvF2= MUjTRW5ITVJ?
NCI-H1395 NYL1Zm9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVWw[2FpUUN3ME2yMlE5ODlzIN88US=> NXrE[mQyW0GQR1XS
GAMG M4LUeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe4V3ZKSzVyPUKuNlM5PDVizszN M1T6fnNCVkeHUh?=
LB1047-RCC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTJwMkSzNVch|ryP M1jYNnNCVkeHUh?=
MN-60 NFrMNoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf5SWJKSzVyPUKuNlk6OjNizszN MV3TRW5ITVJ?
OAW-28 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJwMkm5OVEh|ryP MY\TRW5ITVJ?
NCI-H2228 M4fYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LwNmlEPTB;Mj6zNVU2OiEQvF2= MoXHV2FPT0WU
ABC-1 M1u4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\KU4JuUUN3ME2yMlM{OjV|IN88US=> Mo\2V2FPT0WU
LS-513 NHTaV5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17mWGlEPTB;Mj6zN|Q5PCEQvF2= MljqV2FPT0WU
KS-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK0OnVDUUN3ME2yMlM5OTlzIN88US=> M3;sbnNCVkeHUh?=
NB69 NEnMZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG0PJBKSzVyPUKuN|g6QDNizszN M4PrPHNCVkeHUh?=
VM-CUB-1 NUWxWZp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTJwM{mwPFMh|ryP NEe1OZJUSU6JRWK=
D-423MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV73V2NSUUN3ME2yMlQyODR2IN88US=> M1fOWnNCVkeHUh?=
EW-18 M4LPN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rCWGlEPTB;Mj60NVk{QSEQvF2= MUXTRW5ITVJ?
YH-13 NI\3e|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLJTWM2OD1{LkS2NVU{KM7:TR?= NWLXb|Q3W0GQR1XS
T-24 M{TDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfiPXFKSzVyPUKuOFc5QDFizszN MVjTRW5ITVJ?
ES8 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrERlRKSzVyPUKuOFkzQDdizszN NX:ycIJvW0GQR1XS
ES3 NHzQ[HVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HabWlEPTB;Mj60PVc2QSEQvF2= Mon5V2FPT0WU
RXF393 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ruXWlEPTB;Mj62NFQ5PyEQvF2= NVLmTmlKW0GQR1XS
RPMI-8226 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PnO2lEPTB;Mj62Nlk2OyEQvF2= NILETYdUSU6JRWK=
AGS MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17hdGlEPTB;Mj63NlE{PyEQvF2= MVXTRW5ITVJ?
HCC1395 NVr1c4FwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHZUG9KSzVyPUKuO|UyQDdizszN M1HrenNCVkeHUh?=
MV-4-11 M2LEdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml20TWM2OD1{Lke1NlY3KM7:TR?= NHHLZmZUSU6JRWK=
A204 NGe2U|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJwOEO4O|Ih|ryP NFi5e4RUSU6JRWK=
MCF7 M3;Dfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\sTWM2OD1{Lki2NVE4KM7:TR?= NWixdIpyW0GQR1XS
SNU-423 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDGSnNQUUN3ME2yMlg6OjR{IN88US=> MULTRW5ITVJ?
NCI-H1048 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXMTWM2OD1{Lkm2PFY2KM7:TR?= NVvDcZdZW0GQR1XS
GR-ST MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLOTWM2OD1|LkC0OlEyKM7:TR?= M2XYb3NCVkeHUh?=
EoL-1- MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTNwMEewOVgh|ryP NWLFRXA3W0GQR1XS
HuH-7 NGD1UpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\BV3NKSzVyPUOuNFk1PjRizszN NEjJWFFUSU6JRWK=
OS-RC-2 NWfB[3ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHzVXhKSzVyPUOuNVEyQSEQvF2= MXrTRW5ITVJ?
EW-3 NY[3cGxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LhWWlEPTB;Mz6xPVUzQSEQvF2= MXPTRW5ITVJ?
NCI-H747 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jTTWlEPTB;Mz6yNFY6PCEQvF2= NWfDOpI6W0GQR1XS
EW-16 M4H1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTNwMkG4O|kh|ryP MmHxV2FPT0WU
DOK M2\kfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m2VGlEPTB;Mz6yNlg2QSEQvF2= NVuydYNzW0GQR1XS
HCC2157 Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3mxTWlEPTB;Mz6zPFE4QSEQvF2= MV7TRW5ITVJ?
OVCAR-3 M{LocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGO0VolKSzVyPUOuOFA4QDZizszN M{PKUHNCVkeHUh?=
NCI-H1623 M{j3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofETWM2OD1|LkSxNlI1KM7:TR?= NFH6NohUSU6JRWK=
H4 M17mOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfTTWM2OD1|LkS1OlI3KM7:TR?= M3zC[HNCVkeHUh?=
SW1710 NWnpbpZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;oeHI3UUN3ME2zMlQ3Pjd6IN88US=> NU\JRlJ5W0GQR1XS
RT-112 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEGyU2RKSzVyPUOuOVI{QDhizszN NEPVbHNUSU6JRWK=
DMS-114 NVTrRVVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\QWJBHUUN3ME2zMlYzOjd6IN88US=> MXfTRW5ITVJ?
AN3-CA NUjLXWtbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFraU25KSzVyPUOuOlI1PTZizszN MVjTRW5ITVJ?
KNS-62 MmS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G2VWlEPTB;Mz62N|M{QCEQvF2= NFLnW4lUSU6JRWK=
SJRH30 M2rLWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTjTWM2OD1|Lk[5NVIzKM7:TR?= M{SyfHNCVkeHUh?=
G-402 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{e1fGlEPTB;Mz63NFcyOSEQvF2= NV7aNoxXW0GQR1XS
MHH-PREB-1 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfSR5lKSzVyPUOuO|IxOzhizszN Mlv4V2FPT0WU
P30-OHK M33CWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPR[|N{UUN3ME2zMlgxQTd4IN88US=> MnLPV2FPT0WU
RVH-421 NYGwcnF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGC2PIJKSzVyPUOuPFE4QDhizszN Mn3oV2FPT0WU
LU-134-A M{H6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnMT|h2UUN3ME2zMlg5PDJ6IN88US=> M{HHZXNCVkeHUh?=
ECC10 NF:1WZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTNwOUO2NlIh|ryP M{XQfXNCVkeHUh?=
TGW NHr1UJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LVTmlEPTB;ND6wNlMxPSEQvF2= M1vaSnNCVkeHUh?=
MLMA NVLDbJRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3VV5A5UUN3ME20MlAzQTZ4IN88US=> NFjJRXFUSU6JRWK=
SCC-25 NXXpT3l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLWbphNUUN3ME20MlA3PTZ4IN88US=> MUjTRW5ITVJ?
TYK-nu MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoG2TWM2OD12LkC5OVM1KM7:TR?= MULTRW5ITVJ?
LAMA-84 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC0[Hc5UUN3ME20MlE1OTlzIN88US=> MlH4V2FPT0WU
Calu-3 MlXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3XcWU{UUN3ME20MlI1PDF4IN88US=> NXX6U3BKW0GQR1XS
NCI-H460 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILWSohKSzVyPUSuNlY1PDNizszN M4TNd3NCVkeHUh?=
EGI-1 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXOTWM2OD12LkO3O|c5KM7:TR?= NVvvcnVuW0GQR1XS
NCI-H292 NUP0N4QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nPdmlEPTB;ND6zPFE1PiEQvF2= MkfEV2FPT0WU
HCE-T NF7kV4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfBd4VKSzVyPUSuOFE2PzlizszN M3\yeHNCVkeHUh?=
EW-11 MmDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTRwNEG4N|gh|ryP MXTTRW5ITVJ?
ATN-1 NV\EOo9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLBXYtyUUN3ME20MlQ1OzB2IN88US=> NH;6cGdUSU6JRWK=
NB5 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\nTWM2OD12LkWzOlk4KM7:TR?= NIS1[plUSU6JRWK=
KLE MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPRTWM2OD12LkewNVk5KM7:TR?= Mk[1V2FPT0WU
CAL-39 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7rWXhwUUN3ME20MlczOTR4IN88US=> M3nZdXNCVkeHUh?=
TI-73 NGfHbGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjp[VJKSzVyPUSuPFA3ODlizszN MYXTRW5ITVJ?
HO-1-N-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml23TWM2OD12Lkm0NkDPxE1? MlLpV2FPT0WU
786-0 MoCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHheXdKSzVyPUSuPVQ3PzNizszN M4\kXXNCVkeHUh?=
SK-N-DZ M2n0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fmXGlEPTB;ND65OlE1OiEQvF2= M173[XNCVkeHUh?=
NCI-H446 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzRdXFNUUN3ME21MlIxODB7IN88US=> MmL0V2FPT0WU
ETK-1 NVHnUIUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnTR2dqUUN3ME21MlIyOTZ3IN88US=> MnmyV2FPT0WU
BT-20 M{LqVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHZOYhKSzVyPUWuNlE{PTNizszN MUDTRW5ITVJ?
MEL-HO MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS4TWM2OD13LkO3N|M3KM7:TR?= NHP5b|JUSU6JRWK=
CAL-27 NHnCWJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX6wTGRbUUN3ME21MlQ3OzN7IN88US=> NH;DZ2ZUSU6JRWK=
SW872 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTVwNUm0Nlgh|ryP NWD0dWpDW0GQR1XS
RPMI-2650 M3PoTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7k[4F6UUN3ME21MlY3OTl7IN88US=> NGXTT4FUSU6JRWK=
PFSK-1 M2K5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTVwN{K3N|Ih|ryP M2PWcnNCVkeHUh?=
SF295 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTVwOEC2N|Mh|ryP NYXTbZhUW0GQR1XS
Becker M3vkfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nvfWlEPTB;NT64OlQ4OiEQvF2= NFnQcJJUSU6JRWK=
Saos-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmSwTWM2OD13Lki2OVMh|ryP NVz2Oo9ZW0GQR1XS
SK-OV-3 M2\DR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnIeHNWUUN3ME21Mlk6QDF4IN88US=> MnPPV2FPT0WU
VMRC-RCZ NWO5d|VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTZwMEi3O|Mh|ryP M{X3dnNCVkeHUh?=
EW-22 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjkNFZKSzVyPU[uNVk3PDlizszN M3X2VnNCVkeHUh?=
BT-474 Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEO0Tm9KSzVyPU[uNlM{KM7:TR?= M3izenNCVkeHUh?=
BFTC-909 M1y3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfFO3ZKSzVyPU[uN|A{PDVizszN MXrTRW5ITVJ?
NB12 Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nybGlEPTB;Nj6zPVA4OSEQvF2= M4LibHNCVkeHUh?=
D-263MG Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTZwNEWxOlkh|ryP M3Pwd3NCVkeHUh?=
SNB75 NY\KcpE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HFW2lEPTB;Nj62NFE1OyEQvF2= M4nBPHNCVkeHUh?=
A704 NELoUFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTZwNkOwOkDPxE1? NHf4THNUSU6JRWK=
NCI-H1693 M1vGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXZR2pKSzVyPU[uOlM3ODRizszN Mn:yV2FPT0WU
LN-405 NV\IWJJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnPTWM2OD14Lke5OlczKM7:TR?= MYfTRW5ITVJ?
CHL-1 NWTye25vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTZwOECwO|kh|ryP NXKycJB2W0GQR1XS
A498 NVLvZXcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTZwOEG5OlEh|ryP MVvTRW5ITVJ?
TE-12 M{GzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTZwOEO4NVch|ryP NWToW2JJW0GQR1XS
TE-6 NILaPZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHnXox3UUN3ME22Mlk{ODN6IN88US=> M4DUb3NCVkeHUh?=
AU565 NFr6VINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjhN41UUUN3ME22Mlk3QTV5IN88US=> NWDEVFZSW0GQR1XS
RD NY\RWZB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTZwOUiyPFQh|ryP NU[wcXVrW0GQR1XS
SW1463 M4TBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fQOGlEPTB;Nz6xNVE3QCEQvF2= NGHMOYVUSU6JRWK=
LU-99A M2\lNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfGNGJKSzVyPUeuNVQ{OjJizszN MX7TRW5ITVJ?
NCI-H28 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTdwMkmyOEDPxE1? NGDicW9USU6JRWK=
MC-IXC MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLaTWM2OD15LkS4OVc3KM7:TR?= M3Hy[XNCVkeHUh?=
GP5d MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjpWWtKSzVyPUeuOFg4PjRizszN NHfD[|VUSU6JRWK=
GB-1 NUnN[ZhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j1PGlEPTB;Nz61OFgxPCEQvF2= M2jOWHNCVkeHUh?=
CAL-33 NYSzd|d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHZSWJNUUN3ME23MlY3OjN|IN88US=> NWTUeFJxW0GQR1XS
MSTO-211H MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TO[mlEPTB;Nz62O|M{PiEQvF2= NVXacW4zW0GQR1XS
TE-5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTdwN{mzN|Qh|ryP NF3oZ4tUSU6JRWK=
D-566MG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTweFVKSzVyPUiuNFQ1OjlizszN M3SySXNCVkeHUh?=
JVM-3 NGPGcWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHTSIFUUUN3ME24MlE2OjZ6IN88US=> M13WV3NCVkeHUh?=
T98G NXfYWoN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rHb2lEPTB;OD6xPFA3PyEQvF2= MWHTRW5ITVJ?
HCC1954 M2rOfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRThwNEWxNFQh|ryP NYXMcHpiW0GQR1XS
SF126 NEKyS5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLVTWM2OD16LkS1PVM3KM7:TR?= MVLTRW5ITVJ?
LB996-RCC NYTqOllUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRThwNUOyOVch|ryP NVTkZnQ4W0GQR1XS
SKG-IIIa NU\BN2tMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTzPGhKSzVyPUiuOlMxPjlizszN M4jneXNCVkeHUh?=
NCI-SNU-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRThwNkS2OFMh|ryP NH\XfXlUSU6JRWK=
LB771-HNC M3Pz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLtTWM2OD16Lk[0Olk3KM7:TR?= NHToOpZUSU6JRWK=
SCC-4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXPNWJKSzVyPUiuOlgzOTlizszN M{\ZNHNCVkeHUh?=
CAMA-1 NGL4TJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\rO|BoUUN3ME24Mlc4OTR4IN88US=> M1fpXnNCVkeHUh?=
D-502MG NWH0flc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3LfolKUUN3ME24Mlc5PjJ7IN88US=> NUHLTZNjW0GQR1XS
ESS-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe2WVlNUUN3ME24Mlg5PzB2IN88US=> NGHNe4dUSU6JRWK=
HEC-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHpTWM2OD16Lki5PFY3KM7:TR?= NGXheZVUSU6JRWK=
NB10 NIP6TlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPGTWM2OD17LkCyNlI1KM7:TR?= NIXtfolUSU6JRWK=
8505C Mkf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTlwMESyN|Ih|ryP NX36NpB4W0GQR1XS
EFO-27 NV[0cotvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTlwMU[0NVIh|ryP NGi4cllUSU6JRWK=
HN MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;yTWM2OD17LkG2OlI5KM7:TR?= MnLpV2FPT0WU
DSH1 NWrZXVFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv4W4FKSzVyPUmuNlA5PyEQvF2= NITUNIpUSU6JRWK=
NBsusSR NFT5N45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXDe5duUUN3ME25MlI4PDB{IN88US=> M2rZPXNCVkeHUh?=
LS-123 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7RV5hKSzVyPUmuN|E4PjFizszN NYLzcoJ{W0GQR1XS
SHP-77 M2K2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nYW2lEPTB;OT6zPVk{PSEQvF2= M4LFe3NCVkeHUh?=
ACN NITiUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nKV2lEPTB;OT61N|I4PyEQvF2= NHHHNWhUSU6JRWK=
U251 MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli4TWM2OD17Lk[1OVQ1KM7:TR?= MlG1V2FPT0WU
A431 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTlwOECyN|gh|ryP M{LLTnNCVkeHUh?=
5637 Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTlwOES5PFQh|ryP Ml7qV2FPT0WU
MDA-MB-157 NIjRN3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW2TWM2OD17LkmyPFc5KM7:TR?= MXzTRW5ITVJ?
A101D NF\2[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\xRlNGUUN3ME25Mlk6QTd2IN88US=> MWnTRW5ITVJ?
YKG-1 NYTRe3lFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGS5[JdKSzVyPUGwMlIxODZizszN MYLTRW5ITVJ?
LAN-6 NHTZSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFyLkKxOlQh|ryP NF7hOVlUSU6JRWK=
OVCAR-5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXjWmlKSzVyPUGwMlI1OzNizszN NYjDS4d{W0GQR1XS
A549 MmLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjoTWM2OD1zMD6zPVc{KM7:TR?= NGL2WpZUSU6JRWK=
no-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHKfmZEUUN3ME2xNE41OzV|IN88US=> MnTvV2FPT0WU
SF539 MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjhOpBKSzVyPUGwMlkxPDFizszN NHn4NmRUSU6JRWK=
A388 NWrxS5dET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFzLkO4PVch|ryP NWTHVmF3W0GQR1XS
DEL MnHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:2TWM2OD1zMT60NlQh|ryP NHroNmdUSU6JRWK=
SW954 M2Dndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFzLkS2Olgh|ryP M175VHNCVkeHUh?=
TK10 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP3TWM2OD1zMT61NlcyKM7:TR?= Mkj2V2FPT0WU
SW756 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnaTWM2OD1zMT61Nlk1KM7:TR?= MmGwV2FPT0WU
PC-3 MmP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rhfGlEPTB;MUGuOVc3PCEQvF2= MlLPV2FPT0WU
ONS-76 NHjvSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTFzLk[zOkDPxE1? MknkV2FPT0WU
A427 NGnwclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjlTWM2OD1zMT63NFk{KM7:TR?= MUXTRW5ITVJ?
MEG-01 NUP6UJFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{WwXGlEPTB;MUGuO|UxQSEQvF2= MXfTRW5ITVJ?
BB30-HNC NYC5e|BOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK4UGdKSzVyPUGxMlc6QDJizszN NF;OVolUSU6JRWK=
NCI-H1299 NWq5OHg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonGTWM2OD1zMT64NFk{KM7:TR?= MlfWV2FPT0WU
GCT M3Thbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3uyVGlEPTB;MUGuPFIzQCEQvF2= MXXTRW5ITVJ?
D-247MG NF3aV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX6ze3gyUUN3ME2xNU46PjZ|IN88US=> MlL4V2FPT0WU
CFPAC-1 M3Hz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLZTWM2OD1zMT65O|gzKM7:TR?= M4HMUXNCVkeHUh?=
EKVX NX;hTJFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTF{LkCzNVMh|ryP MnzDV2FPT0WU
CAL-51 NVnOcHQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq5XWxvUUN3ME2xNk4xPzF4IN88US=> M3Pab3NCVkeHUh?=
BB49-HNC NWLFS4hDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXPTWM2OD1zMj6xNVc4KM7:TR?= MYnTRW5ITVJ?
RPMI-7951 Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjadpVKUUN3ME2xNk4yQDV2IN88US=> NGLUcGlUSU6JRWK=
RH-1 M3Gz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\pTWM2OD1zMj6yNVg1KM7:TR?= MnH1V2FPT0WU
BCPAP MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGixU25KSzVyPUGyMlQ4PDlizszN NHjhenRUSU6JRWK=
GCIY NVTLfIt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF{LkWyNFkh|ryP MmTwV2FPT0WU
KNS-81-FD M{ntWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvYTWM2OD1zMj61PFY6KM7:TR?= NITabWRUSU6JRWK=
KYSE-140 M2DUd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHETWM2OD1zMj64OVk2KM7:TR?= M3njZ3NCVkeHUh?=
Ca-Ski NEPH[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[wZmlEPTB;MUKuPVA1OSEQvF2= NHrPOYJUSU6JRWK=
TGBC1TKB NHe2cI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTF{LkmxNVUh|ryP NXja[|N3W0GQR1XS
HCC1187 M2THeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjMXphrUUN3ME2xN{4yQTF{IN88US=> NX7Pbm06W0GQR1XS
SJSA-1 M1PCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvHN2E{UUN3ME2xN{4zOzJ5IN88US=> M3zwUHNCVkeHUh?=
CTV-1 NUHMW3FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLOc4d[UUN3ME2xN{4{PDVizszN NWfQdIFSW0GQR1XS
WM-115 NUizN4p{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInsWFVKSzVyPUGzMlY1QDNizszN MV;TRW5ITVJ?
CHP-212 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTF|Lkm3N|kh|ryP MWjTRW5ITVJ?
SCC-15 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHLXJVKSzVyPUGzMlk4PzVizszN NX3MSHlJW0GQR1XS
BPH-1 MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPycXBKUUN3ME2xOE4yPjZ2IN88US=> NV\lOZpFW0GQR1XS
SW780 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTF2LkWwNlUh|ryP NG\veWdUSU6JRWK=
NCI-H2291 NWfZUpNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf1cVhCUUN3ME2xOE42QDd6IN88US=> NYnjO5B7W0GQR1XS
JEG-3 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3yyb2lEPTB;MUSuOlMzPiEQvF2= MYXTRW5ITVJ?
CAL-120 M4GxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\FNVFKSzVyPUG0MlcxOjdizszN NUK2UJd3W0GQR1XS
NCI-H23 MmC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorGTWM2OD1zND63PVk4KM7:TR?= MVTTRW5ITVJ?
MS-1 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj5TWM2OD1zND65OlEyKM7:TR?= NITaUmZUSU6JRWK=
PC-14 NXLqZ5NoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jrfGlEPTB;MUSuPVY2PCEQvF2= MVfTRW5ITVJ?
D-283MED MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPxTWM2OD1zNT6wNVEyKM7:TR?= NGOwWpNUSU6JRWK=
OE19 M3XJR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTF3LkG1OFEh|ryP MVHTRW5ITVJ?
CAS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHkVo4{UUN3ME2xOU41OTh2IN88US=> NWO0cWZCW0GQR1XS
NCI-H727 NI\tXHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETKWFlKSzVyPUG1MlQzOjFizszN NVuwUpZxW0GQR1XS
SiHa MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW1SI1YUUN3ME2xOU44PTl2IN88US=> NY\rdmFkW0GQR1XS
BFTC-905 NV3GVFFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTF3Lke2PVQh|ryP M1fveXNCVkeHUh?=
MDA-MB-453 NV2yT|JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC5TWM2OD1zNj6xOlQzKM7:TR?= MYPTRW5ITVJ?
HuP-T3 NYXZ[5JLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfSPYtsUUN3ME2xOk43Ozd|IN88US=> MWjTRW5ITVJ?
SK-LU-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF4Lk[5OVYh|ryP NX;kbYVFW0GQR1XS
Detroit562 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTF4LkezNVgh|ryP M3XZfXNCVkeHUh?=
HCC1569 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTF4LkizN|ch|ryP MYjTRW5ITVJ?
SK-MES-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTF4Lki0NVkh|ryP NF;MPWVUSU6JRWK=
BB65-RCC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fq[2lEPTB;MUeuNFQ4QSEQvF2= MUTTRW5ITVJ?
LOXIMVI MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\J[FloUUN3ME2xO{4xPzB5IN88US=> MW\TRW5ITVJ?
SW1783 Mo\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4njUWlEPTB;MUeuNVI5KM7:TR?= M13zTnNCVkeHUh?=
NH-12 NUmwUXo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3CSJVKSzVyPUG3MlM{ODNizszN MYTTRW5ITVJ?
UACC-257 NVnSRpBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonETWM2OD1zNz61OVEzKM7:TR?= NEXETWxUSU6JRWK=
KOSC-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF5Lk[3OVch|ryP Mk\NV2FPT0WU
KG-1 NUfGfHoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDBdpFFUUN3ME2xO{43QTN5IN88US=> MnjYV2FPT0WU
M059J M4PmOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vrSmlEPTB;MUeuO|A{KM7:TR?= MXzTRW5ITVJ?
MHH-NB-11 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjQ[Y4{UUN3ME2xO{46Pjd|IN88US=> M3HKWnNCVkeHUh?=
EW-1 NIrnXVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXOwVmd5UUN3ME2xPE4yOzh{IN88US=> NFrQZWxUSU6JRWK=
CAL-85-1 M4fFc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjWUJJKSzVyPUG4MlI{PTdizszN NIPaWHlUSU6JRWK=
639-V MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TDb2lEPTB;MUiuN|M2PCEQvF2= NF24U|hUSU6JRWK=
C32 NXvmNokyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTF6LkS3Nlch|ryP M4H6ZXNCVkeHUh?=
KM-H2 NYq2R2VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rwPWlEPTB;MUiuOVI{OiEQvF2= NEHlUVJUSU6JRWK=
A253 M33pNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nYWGlEPTB;MUiuO|I5PiEQvF2= MnLMV2FPT0WU
NCI-N87 NV75bZA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTnTWM2OD1zOD65NFA5KM7:TR?= NIHxdVBUSU6JRWK=
8-MG-BA NU\NVFBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ETWM2OD1zOT6wOlQ3KM7:TR?= NHXIPIdUSU6JRWK=
GI-ME-N M1rhW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF7LkG1OFYh|ryP MoPCV2FPT0WU
8305C M17EUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTKRmJJUUN3ME2xPU4zOjh4IN88US=> NGW4WHhUSU6JRWK=
TE-8 M1L2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi0UHNGUUN3ME2xPU4{ODJ2IN88US=> M1f0OnNCVkeHUh?=
KYSE-270 M2q2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLjU3RKSzVyPUKwMlAzOTdizszN NGruW4tUSU6JRWK=
HL-60 NGjSRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4GyfWlEPTB;MkCuNFk1OSEQvF2= NFzhXFVUSU6JRWK=
Mo-T NXmyU2p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPsUpZoUUN3ME2yNE4yPjZ3IN88US=> NGDNdWZUSU6JRWK=
NCI-H1355 NUmzb493T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K3U2lEPTB;MkCuN|M4PCEQvF2= MWfTRW5ITVJ?
HT-1080 NXHubVJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2roUGlEPTB;MkCuOVQ6PyEQvF2= MUfTRW5ITVJ?
MIA-PaCa-2 M4rse2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;WXWFyUUN3ME2yNE43QDh|IN88US=> NXGyTGxwW0GQR1XS
NCI-H441 Mo\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;RXmlEPTB;MkCuO|M4QSEQvF2= MUTTRW5ITVJ?
LCLC-97TM1 NVLIXIlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrSZoVUUUN3ME2yNE45OTN2IN88US=> NE[5TodUSU6JRWK=
HT-3 Mnv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX3OlM5UUN3ME2yNU42PjNzIN88US=> M3vM[3NCVkeHUh?=
22RV1 NHTVbJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJzLkW2PFUh|ryP MoPMV2FPT0WU
LK-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq1eodKSzVyPUKxMlU6PTNizszN MlTEV2FPT0WU
CW-2 NXi1cXZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX64fFJXUUN3ME2yNU43ODZ7IN88US=> NHXHZ4lUSU6JRWK=
KYSE-510 MoD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJzLk[wPVUh|ryP NXL1dXN{W0GQR1XS
CGTH-W-1 NYDQ[YhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnQbHlKSzVyPUKxMlcyPjZizszN MoDFV2FPT0WU
NCI-H661 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrTXGx1UUN3ME2yNk4xOzRizszN NH:1[I9USU6JRWK=
KU-19-19 NH\nOoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHHb4xKSzVyPUKyMlE3QTdizszN MVzTRW5ITVJ?
NCI-H2122 NUize406T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\a[odKSzVyPUKyMlI1OzJizszN MYHTRW5ITVJ?
NCI-H526 NX;vXot{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rXeGlEPTB;MkKuN|g6PSEQvF2= M4XWdXNCVkeHUh?=
NCI-H1650 NIPlZ5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7pWlFKSzVyPUKyMlc3PCEQvF2= MoHUV2FPT0WU
AM-38 NWK3enVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPLVZpKSzVyPUKyMlg3QDlizszN M1;oVnNCVkeHUh?=
NCI-H2405 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfuNYFKSzVyPUKzMlI2OzNizszN NH:5dYdUSU6JRWK=
M14 NVzYd25CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLGTWM2OD1{Mz60NFg5KM7:TR?= NEHoXHhUSU6JRWK=
ES4 MmjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nKTGlEPTB;MkOuOFI{OiEQvF2= M4W2N3NCVkeHUh?=
DJM-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HiO2lEPTB;MkOuOVI{PCEQvF2= MXnTRW5ITVJ?
S-117 M3XUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ|Lke2OVEh|ryP MkDCV2FPT0WU
MZ2-MEL NFjnfFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[wUGlKSzVyPUKzMlc4PTlizszN NXHkS3duW0GQR1XS
SK-MEL-2 NIP4PXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXrSZdKSzVyPUKzMlgyOzNizszN NFvLfIxUSU6JRWK=
HCC1806 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJ|Lki3NFkh|ryP M2XocXNCVkeHUh?=
NMC-G1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX5Z3NSUUN3ME2yOE4zOjJ4IN88US=> M37neXNCVkeHUh?=
DK-MG M1TkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HU[mlEPTB;MkSuNlk1KM7:TR?= M{LwcHNCVkeHUh?=
SK-N-FI M3rtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjsZXNKSzVyPUK0MlM{ODJizszN NGPHVlBUSU6JRWK=
KINGS-1 NHzKcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ2LkS4O|Qh|ryP NWnWWGNWW0GQR1XS
HCC2998 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf1TWM2OD1{ND60PFg2KM7:TR?= NUTpc5czW0GQR1XS
ALL-PO MofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS0elA{UUN3ME2yOE43OTlizszN NXS2dIo1W0GQR1XS
MPP-89 NHjUeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjURW5KSzVyPUK1MlA1PThizszN Mmq4V2FPT0WU
NCI-H2342 M4fP[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;mSotxUUN3ME2yOU4yQTV|IN88US=> MlXkV2FPT0WU
TE-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XB[2lEPTB;MkWuN|U3OyEQvF2= MkXIV2FPT0WU
RH-18 M{DGPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz2TWM2OD1{NT61PVE5KM7:TR?= M4frZXNCVkeHUh?=
HT-1376 NYGzfJpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWK5WJEzUUN3ME2yOU43PDZ3IN88US=> NUTOOpBlW0GQR1XS
U-2-OS NV\xeFJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJ3Lk[4PFgh|ryP MoXzV2FPT0WU
BT-549 M3jNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJ3LkmwNVEh|ryP NWDwcoxwW0GQR1XS
NCI-H1755 M33vcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL4dZJvUUN3ME2yOU46QTR3IN88US=> MUfTRW5ITVJ?
EW-13 M{j0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH0RlBHUUN3ME2yOk4xOjd2IN88US=> M{TlZXNCVkeHUh?=
NB13 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\4eZI6UUN3ME2yOk4xQTR7IN88US=> MWjTRW5ITVJ?
NUGC-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTiTWM2OD1{Nj6yNVA{KM7:TR?= Mn:2V2FPT0WU
GMS-10 NEXFZVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDSfolKSzVyPUK2MlI{PTNizszN MYDTRW5ITVJ?
CHP-134 NXS2WJBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDOVHJVUUN3ME2yOk4{QDZ5IN88US=> NXjPNWdkW0GQR1XS
SW962 M2\wcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DVcmlEPTB;Mk[uOVAzOSEQvF2= NFLRVW9USU6JRWK=
SNU-449 NGniUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJ5LkC4NFMh|ryP MkDvV2FPT0WU
HuP-T4 MoD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\vTWM2OD1{Nz6wPFc6KM7:TR?= NELtXZNUSU6JRWK=
SW948 NITEW5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3yRZNKSzVyPUK3MlE{PDRizszN NYHTRW9UW0GQR1XS
NCI-H226 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTJ5LkS1O|gh|ryP NGrtd5dUSU6JRWK=
SK-PN-DW NX3jO3NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfSR5B3UUN3ME2yO{43ODF{IN88US=> MnHnV2FPT0WU
GI-1 NX\4SYh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LtSWlEPTB;MkeuO|IyKM7:TR?= M4Dr[nNCVkeHUh?=
CAL-12T MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDYfmNkUUN3ME2yPE4yOTF{IN88US=> M{DIO3NCVkeHUh?=
YAPC M4XTNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJ6LkK1OlQh|ryP Mn;VV2FPT0WU
SNU-C2B M1\UWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTkTlJKSzVyPUK4MlI6PjRizszN MXHTRW5ITVJ?
RCC10RGB NGfiUGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PSSmlEPTB;MkiuOVQyPyEQvF2= Mn\LV2FPT0WU
ES7 NFXtWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f2WWlEPTB;MkmuNVQ3PSEQvF2= MmD2V2FPT0WU
PANC-03-27 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTvVXJtUUN3ME2yPU41PDRizszN NXqxT5RqW0GQR1XS
ES6 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJ7LkixOVch|ryP M321dXNCVkeHUh?=
HT-1197 NET6R4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTTTWM2OD1|MD6wOVk5KM7:TR?= M3f0c3NCVkeHUh?=
ZR-75-30 Mm\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTNyLkKzPFMh|ryP NH;LU2JUSU6JRWK=
DB MnvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTNyLkS5OFIh|ryP NW\YcXFEW0GQR1XS
OCI-AML2 M{DsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTNzLkC2PUDPxE1? MVfTRW5ITVJ?
NCI-H2170 MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljHTWM2OD1|MT64OVE3KM7:TR?= MYDTRW5ITVJ?
IST-MES1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTN{LkK4PVch|ryP NWOyV4lRW0GQR1XS
769-P MnLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTN{LkO2OFEh|ryP MXTTRW5ITVJ?
COR-L23 NEXRWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTN{LkmwO|Mh|ryP NVTXNItYW0GQR1XS
SW626 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTlOZI2UUN3ME2zN{4yPzd4IN88US=> NYHMNolLW0GQR1XS
LU-139 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrDdGxKSzVyPUOzMlY3ODVizszN NYLocJJ6W0GQR1XS
HT-144 NXnrOIpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTKO4FKSzVyPUOzMlg3OyEQvF2= MlXCV2FPT0WU
CaR-1 NWq3UFA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[zcnRWUUN3ME2zN{46QDJ{IN88US=> NIjRZ3BUSU6JRWK=
OE33 M3LhTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33HdWlEPTB;M{SuNlg2PSEQvF2= M4rqVnNCVkeHUh?=
COLO-800 NFjJfo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz3eVhKSzVyPUO0MlM3PDdizszN NUDSWppsW0GQR1XS
NB14 M2\YSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTN2LkS2PFQh|ryP M1jJPXNCVkeHUh?=
KURAMOCHI MorZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTuTItKSzVyPUO2MlEyQThizszN NWLMcmxWW0GQR1XS
SW48 NG\DfpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfpe457UUN3ME2zOk4zPDd2IN88US=> MlfuV2FPT0WU
Daoy MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\pdWlEPTB;M{[uOlU{QCEQvF2= Mn7EV2FPT0WU
TGBC24TKB NEnxZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTN4Lk[3JO69VQ>? MVrTRW5ITVJ?
DU-4475 Ml;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHOTWM2OD1|Nj65NFM{KM7:TR?= NUHaboNoW0GQR1XS
SW1417 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PsdGlEPTB;M{iuNFU2OiEQvF2= M{HXOHNCVkeHUh?=
EFO-21 NITudFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\3SZJKSzVyPUO4Mlk{PDlizszN NFnsPIdUSU6JRWK=
MG-63 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17LeGlEPTB;M{muN|QzPCEQvF2= MXXTRW5ITVJ?
LC-2-ad NWfaWlh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4izVmlEPTB;M{muOVUyOiEQvF2= NFrOOXFUSU6JRWK=
NOMO-1 NGXKPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rEOmlEPTB;M{muPFI4PCEQvF2= NFnYWodUSU6JRWK=
COLO-741 NF\vRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jPTGlEPTB;NECuNVMxPCEQvF2= MVHTRW5ITVJ?
BxPC-3 M2nQSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXMTWM2OD12MD61Olg3KM7:TR?= M17Ze3NCVkeHUh?=
HSC-2 NVrIcIU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e0d2lEPTB;NECuPVEyOyEQvF2= Mn;sV2FPT0WU
UMC-11 NYHvW|U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTYbHVKSzVyPUSxMlI3OyEQvF2= MULTRW5ITVJ?
HCC1937 Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPiTWM2OD12Mj63PFQ{KM7:TR?= NEK3R21USU6JRWK=
Calu-6 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O5VmlEPTB;NEOuNlM5OiEQvF2= NIfuc4NUSU6JRWK=
NCI-H1573 NGH3e5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:wepBKSzVyPUSzMlM1PzdizszN M1zlZ3NCVkeHUh?=
SK-N-AS M{myWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTR|Lk[wNVkh|ryP M3nNS3NCVkeHUh?=
PSN1 NUOzWGczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7lTWM2OD12NT6yOVQ5KM7:TR?= NELIbHdUSU6JRWK=
TE-11 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTWTWM2OD12NT60PFQzKM7:TR?= M2XV[nNCVkeHUh?=
NCI-H1155 MnXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3CNlZKSzVyPUS1Mlg6PjdizszN M{TFfXNCVkeHUh?=
KM12 NIjSbFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3YXW52UUN3ME20OU46ODd4IN88US=> MnHUV2FPT0WU
RO82-W-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTjTWM2OD12Nj65PFIzKM7:TR?= NXLZNZdQW0GQR1XS
SW1573 NYezcHZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fTRWlEPTB;NEeuN|c{PiEQvF2= MYjTRW5ITVJ?
CAKI-1 M{LCOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPDTWM2OD12OD6yPFQ2KM7:TR?= MnjGV2FPT0WU
U-118-MG MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTTOJhFUUN3ME20PE4{PzB{IN88US=> NGTycGdUSU6JRWK=
KYSE-520 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXTTWM2OD12OD60NFE3KM7:TR?= NGDLN3FUSU6JRWK=
HT55 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnlTWM2OD12OT6xOFc1KM7:TR?= MWHTRW5ITVJ?
ChaGo-K-1 NXX1bGFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfWVZhKSzVyPUS5MlQ4QTNizszN MYLTRW5ITVJ?
IA-LM NGOxOZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\BTWM2OD13ND62N|IzKM7:TR?= MnzLV2FPT0WU
UACC-62 M1;6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHQXFREUUN3ME21OU4yODR4IN88US=> M3nXO3NCVkeHUh?=
MKN7 MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;Bc2lEPTB;NU[uNFI5PSEQvF2= MofiV2FPT0WU
HPAF-II NWK0W2MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDkOXVKSzVyPUW2MlQxPzNizszN NET0V3JUSU6JRWK=
NTERA-S-cl-D1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n5OmlEPTB;NUeuO|c5KM7:TR?= M1T0WXNCVkeHUh?=
FTC-133 NW[5[WVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPETWM2OD13OD6wPVY6KM7:TR?= NIjvOWtUSU6JRWK=
MHH-ES-1 NULRSXZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\l[2lEPTB;NUiuOFgyPCEQvF2= M33BenNCVkeHUh?=
JVM-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofGTWM2OD13OD65OVA3KM7:TR?= MWHTRW5ITVJ?
TCCSUP NEXSe3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInHdG1KSzVyPUW5MlUzPzlizszN NHrQfXhUSU6JRWK=
COLO-824 M4rFfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H3bGlEPTB;NkCuNFcyQSEQvF2= MlfjV2FPT0WU
647-V NHzZRYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;4TFhKSzVyPU[wMlE{PDdizszN NYO2NY9DW0GQR1XS
HD-MY-Z MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzQOI1KSzVyPU[wMlUzQTRizszN M{j2NXNCVkeHUh?=
LS-411N NHrnTXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjOTWM2OD14MT6zPVA{KM7:TR?= MUjTRW5ITVJ?
NCI-H596 MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHhPVZbUUN3ME22Nk44PDl4IN88US=> NVjxU21IW0GQR1XS
C-33-A M{DzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjZbnlKSzVyPU[0MlA6PTdizszN Mon0V2FPT0WU
BHY M4[4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mli4TWM2OD14ND6xNlQ2KM7:TR?= NU\3[mNDW0GQR1XS
KGN NGO0SXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTZ2LkW1NVQh|ryP MY\TRW5ITVJ?
NCI-H1092 NIK1Z|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHPTWM2OD14NT6wNFk2KM7:TR?= NYfpUoFuW0GQR1XS
MZ1-PC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTZ3LkW2OFkh|ryP MmGxV2FPT0WU
LB831-BLC NXyxVVB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXHTWM2OD14NT64OFgyKM7:TR?= NXrPT|ZbW0GQR1XS
SW620 NXTIRmY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ixRWlEPTB;Nk[uNlA{QSEQvF2= NGL6fZBUSU6JRWK=
HuO-3N1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e5VmlEPTB;NkiuN|I{QCEQvF2= Mnn4V2FPT0WU
SK-HEP-1 M{H0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHETWM2OD14OT65OFg3KM7:TR?= M37V[XNCVkeHUh?=
LCLC-103H NIXGc4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTdyLk[3NFUh|ryP M33jTHNCVkeHUh?=
KYSE-70 NIXuVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3uzemlEPTB;N{CuO|g{PSEQvF2= MXHTRW5ITVJ?
Mewo NF7Wb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;wemU3UUN3ME23NU42ODVizszN M1Tkc3NCVkeHUh?=
COLO-668 NXzNfJN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHzNIJKSzVyPUexMlg1PTFizszN M3rGUHNCVkeHUh?=
NCI-H522 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTd{LkO0NVMh|ryP NWHsR5R1W0GQR1XS
NCI-H1437 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFqx[45KSzVyPUe0MlQxPDhizszN NYe4XJBVW0GQR1XS
U-266 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXjWlQxUUN3ME23OU41PTF4IN88US=> NELUTFdUSU6JRWK=
MC116 NIW2NFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLFO5BKSzVyPUe1MlU4ODhizszN M{\4bnNCVkeHUh?=
PANC-10-05 NHT2fHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP4TWM2OD15Nz60NlQ{KM7:TR?= NXezdVhOW0GQR1XS
KYSE-180 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL6TWM2OD15Nz61OFU1KM7:TR?= MVHTRW5ITVJ?
JAR NYjCfWhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTd7LkC1OFYh|ryP MmW2V2FPT0WU
CAL-62 M4Hlemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fpbGlEPTB;OECuNFk2KM7:TR?= M{[0cnNCVkeHUh?=
A3-KAW NVnVNod3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnl[IhHUUN3ME24NE4zOTV2IN88US=> MW\TRW5ITVJ?
PANC-08-13 NWXxeFVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF30cXlKSzVyPUixMlE4PjhizszN MYrTRW5ITVJ?
HSC-3 NVTDXJdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG0Wox3UUN3ME24N{4{ODdzIN88US=> NIjPbW5USU6JRWK=
HTC-C3 NYnkd|V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfOZ5VoUUN3ME24N{41PzB{IN88US=> Mo\WV2FPT0WU
KY821 NID5RoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTh2LkC4PVIh|ryP NHTiTHJUSU6JRWK=
DoTc2-4510 M1fsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq4WXZKSzVyPUi0MlIyQDVizszN M3v0UXNCVkeHUh?=
NCI-H1581 NHHyZ|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLGb29HUUN3ME24OU41PjRzIN88US=> M1;QbnNCVkeHUh?=
KARPAS-299 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XsUGlEPTB;OE[uNVk4PyEQvF2= M2rQRXNCVkeHUh?=
IST-MEL1 M4PXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO5VZdKSzVyPUi2Mlg5PzJizszN MnXhV2FPT0WU
KP-N-YS NFHLW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NED4PVJKSzVyPUi5MlkxOjhizszN MnLQV2FPT0WU
KYSE-410 MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHMb|FKSzVyPUmxMlQxPDJizszN NUHWUWF1W0GQR1XS
TE-10 NUHabnJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTlzLkW2NVEh|ryP M1r0[XNCVkeHUh?=
SK-MEL-1 NX3OV2lNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTl{LkmxNFYh|ryP NUfjWWtGW0GQR1XS
COLO-792 M2\2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS0TWM2OD17NT6yOVY1KM7:TR?= M3\ZbHNCVkeHUh?=
SCH MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTl4LkO4O|ch|ryP NFjmU4ZUSU6JRWK=
NCI-H1792 NEDrTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;GTWM2OD17Nj64PVkzKM7:TR?= NGnVTGtUSU6JRWK=
NCI-H2029 NV7jNop4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLLbotQUUN3ME25Ok46PTZ4IN88US=> NHq5OmZUSU6JRWK=
SW684 MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvSTWM2OD17OD62OlU1KM7:TR?= M1zONHNCVkeHUh?=
NCI-H209 NXuydWxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S1TWlEPTB;MUCwMlEzOSEQvF2= MYPTRW5ITVJ?
HLE NYjZ[YxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\VTmhKSzVyPUGwOU4zQDJizszN Mn21V2FPT0WU
GOTO MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFyNz63O|ch|ryP M2nncXNCVkeHUh?=
NCI-H1793 M4CwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm1TWM2OD1zMEmuNlgh|ryP M4f4PXNCVkeHUh?=
D-392MG MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFzNz6zPVgh|ryP MkPZV2FPT0WU
SW1990 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnvVGFRUUN3ME2xNlAvQTVzIN88US=> Mn6xV2FPT0WU
ML-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljRTWM2OD1zMkGuOlc3KM7:TR?= M3nZV3NCVkeHUh?=
NCI-H2452 NX73T3ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;kTWM2OD1zMkKuNlEh|ryP NVXkcYI1W0GQR1XS
SK-MEL-30 NHy2ZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHmxT4pKSzVyPUGyN{4zPDRizszN NXG5OmdHW0GQR1XS
SN12C MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnaTWM2OD1zMkSuNVc3KM7:TR?= NVLIZYU5W0GQR1XS
NCI-H1770 Moe2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PPeWlEPTB;MUK1MlUyPCEQvF2= M2XEfHNCVkeHUh?=
SF268 M2jxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\YOVFKSzVyPUGyOk4yPThizszN M{Pyd3NCVkeHUh?=
BALL-1 NGnsXWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPveZBNUUN3ME2xNlYvOjNizszN M1LzfXNCVkeHUh?=
COLO-679 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTF{Nj63OVMh|ryP M2i3[HNCVkeHUh?=
A2780 M2i4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTF{OD65PFgh|ryP NX;tc|R6W0GQR1XS
NCI-H1651 MlHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfXcWdRUUN3ME2xN|EvOjR|IN88US=> M1HLfnNCVkeHUh?=
NCI-H2087 NFywfG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXaXZZsUUN3ME2xN|EvPDh|IN88US=> M3HQXXNCVkeHUh?=
U-87-MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\aSXhLUUN3ME2xN|MvPjB2IN88US=> MY\TRW5ITVJ?
LB2518-MEL M4jyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;JTWM2OD1zM{WuPVk{KM7:TR?= M{m1eHNCVkeHUh?=
HCT-116 NVzQNFJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTF|Nz6yNVch|ryP MoHmV2FPT0WU
Ca9-22 NYTxRpQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M12wPWlEPTB;MUO5Mlg{OyEQvF2= MWHTRW5ITVJ?
COR-L88 M3;nSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XRVWlEPTB;MUSyMlE1KM7:TR?= MYXTRW5ITVJ?
CP50-MEL-B Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i0UGlEPTB;MUS0MlUxOSEQvF2= MWrTRW5ITVJ?
OVCAR-8 NXPWendNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTF2NT62N|Yh|ryP M2\RcHNCVkeHUh?=
SK-MEL-3 MonGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLsTWM2OD1zNEeuPFc5KM7:TR?= M1;ifXNCVkeHUh?=
GT3TKB NInDPZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3I[4NWUUN3ME2xOFkvQTJ6IN88US=> NF3KPXNUSU6JRWK=
KYSE-450 MnfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF3MT61N|kh|ryP NFvXbm9USU6JRWK=
CAPAN-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESwOY1KSzVyPUG1N{4xPjRizszN Mnv1V2FPT0WU
BEN NInWe5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF3Mz65Nlgh|ryP NXPPSpBOW0GQR1XS
NCI-H1304 M4fMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrDTWM2OD1zNUSuOlk1KM7:TR?= MkfJV2FPT0WU
KU812 MkO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;FS4JtUUN3ME2xOVgvPjd2IN88US=> MmjWV2FPT0WU
Capan-2 M3Lo[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\RTWM2OD1zNkCuOVU{KM7:TR?= M2O4cXNCVkeHUh?=
A673 NWW5cJRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO1OZpOUUN3ME2xOlEvPzB3IN88US=> MXvTRW5ITVJ?
SAS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jmfWlEPTB;MU[yMlY4QCEQvF2= NXH4d45VW0GQR1XS
NY MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[1cWlEPTB;MU[1MlMyPCEQvF2= NFnjboNUSU6JRWK=
HCE-4 MoTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTF4Nj64OFUh|ryP NUiyT5BPW0GQR1XS
MDA-MB-231 NFvWSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\tZoFKSzVyPUG3O{42ODNizszN NG\HVnpUSU6JRWK=
no-10 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET5PIRKSzVyPUG3PE4yOzRizszN NGrWUnRUSU6JRWK=
MZ7-mel NHn2XHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmmwTWM2OD1zN{iuOFY4KM7:TR?= NGf1U5JUSU6JRWK=
NCI-H82 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF6MD6xOlUh|ryP M3LENXNCVkeHUh?=
CAL-72 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLuNmZzUUN3ME2xPFUvODV2IN88US=> NEjn[XJUSU6JRWK=
NCI-SNU-5 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4D1SWlEPTB;MUi2Mlg1KM7:TR?= MXzTRW5ITVJ?
OVCAR-4 M1HpUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn4TVhKSzVyPUG4PE4{OzNizszN MlvIV2FPT0WU
SCC-9 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\PN2lEPTB;MUmxJO69VQ>? Mm\PV2FPT0WU
KYSE-150 Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi1bnZKSzVyPUG5NU45QDhizszN NYPXfWdzW0GQR1XS
HT-29 NIPXfGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHFWZpKSzVyPUKwNU4zOTJizszN NXXYVVFmW0GQR1XS
COLO-678 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fQVmlEPTB;MkCxMlQ2KM7:TR?= NILENVdUSU6JRWK=
NCI-H650 NFj1dJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTYSYl3UUN3ME2yNFIvOTB|IN88US=> MVTTRW5ITVJ?
HuCCT1 NUPwdZdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITzd45KSzVyPUKwOE4zODhizszN NUCzeFFvW0GQR1XS
SW1116 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTrTWM2OD1{MEeuNFc4KM7:TR?= M4jocXNCVkeHUh?=
DBTRG-05MG NETySYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjpS49UUUN3ME2yNFcvQTB7IN88US=> NYXYPVlWW0GQR1XS
SW982 NVn3ZVFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJyNz65OFgh|ryP NFvCOnVUSU6JRWK=
RCM-1 NHvBbY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTJzND63OlIh|ryP M3LIfHNCVkeHUh?=
COLO-320-HSR NYjzSZFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPSTWM2OD1{MU[uNVI2KM7:TR?= MmjEV2FPT0WU
KNS-42 MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zofmlEPTB;MkG2MlU4PCEQvF2= M3XybnNCVkeHUh?=
C2BBe1 NETiXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJ|MT65NFUh|ryP MmWyV2FPT0WU
CCRF-CEM M3fLT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzEdGdKSzVyPUK0N{44QTVizszN NEDOO4dUSU6JRWK=
SH-4 NITOPHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vhVmlEPTB;MkS2MlA6KM7:TR?= Mkn2V2FPT0WU
LS-1034 NIHVfHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PFUWlEPTB;MkS2MlI3PiEQvF2= M1jqcnNCVkeHUh?=
NCI-H2347 NYHmfIxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGmyO|JKSzVyPUK0O{44OTNizszN M2jmUHNCVkeHUh?=
RPMI-8866 MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjOboh2UUN3ME2yOFkvOjdizszN M3rzXnNCVkeHUh?=
GAK MnPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELuV3BKSzVyPUK1N{4xODJizszN M{P1bXNCVkeHUh?=
NB6 NWfJfWZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHqTWM2OD1{N{CuNUDPxE1? MYDTRW5ITVJ?
COLO-680N M1Xodmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PoUWlEPTB;MkeyMlUzPyEQvF2= M4XKbXNCVkeHUh?=
RERF-LC-MS MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrjTWM2OD1{N{[uNFA4KM7:TR?= NHW3epVUSU6JRWK=
TGBC11TKB NVHLSlNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXUZoxKSzVyPUK3PE4yPzhizszN NXy3W|VuW0GQR1XS
C8166 NVe1XVhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXnW4VKSzVyPUK3PE42ODZizszN M2L0R3NCVkeHUh?=
HDLM-2 NGfOVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLnNFR1UUN3ME2yPVQvPDB7IN88US=> M3XzenNCVkeHUh?=
IGR-1 NHjIVIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nRb2lEPTB;Mkm1MlY2QSEQvF2= M{\wbHNCVkeHUh?=
FADU M2T6cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLkdXJsUUN3ME2yPVcvPTFizszN NVSyXZY3W0GQR1XS
L-428 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nI[WlEPTB;Mkm3MlYyPiEQvF2= NG\KOYhUSU6JRWK=
LU-65 M4\mcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HSTGlEPTB;M{C0MlMzKM7:TR?= NULzZnBlW0GQR1XS
HEL MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPMXXZKSzVyPUOwPU46QDNizszN M{C5bnNCVkeHUh?=
NCI-H810 MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPZPZBYUUN3ME2zNVAvPTdizszN Mm\XV2FPT0WU
C3A NIS5TYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfpNlFKSzVyPUOxNU45ODJizszN NX;ncoJkW0GQR1XS
NCI-H630 M{PJSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTN|Mj6yPVQh|ryP MWrTRW5ITVJ?
KP-N-YN NHXhR4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTN2MT6xNlMh|ryP NGTuT|JUSU6JRWK=
MOLT-13 NV:ycVJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXUW3N3UUN3ME2zOFIvOzJ4IN88US=> M37nV3NCVkeHUh?=
NCI-H1993 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTN2Mj6zOlUh|ryP M3ruN3NCVkeHUh?=
BE-13 NUH2ZWl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm1ZWhIUUN3ME2zOFQvOTZ5IN88US=> NIHVbIpUSU6JRWK=
IST-SL1 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC3dZZjUUN3ME2zOFcvPDBzIN88US=> M1:0fHNCVkeHUh?=
TE-9 M{L2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkSxTWM2OD1|NkOuOVg6KM7:TR?= NYDVNJM6W0GQR1XS
LU-135 NUTl[IlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTN4Nz6wN|Uh|ryP Mlr0V2FPT0WU
T84 M{XGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrWTWM2OD1|N{SuO|EzKM7:TR?= NUHET2NxW0GQR1XS
K-562 NWPiNVVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTN6Mz6zOkDPxE1? MorjV2FPT0WU
SBC-5 M2S0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLtcnhbUUN3ME2zPFYvQTh3IN88US=> NV3xfoVtW0GQR1XS
NB17 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTN7Mj61PVYh|ryP NInrXldUSU6JRWK=
NCI-H2052 NHnzNpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX0dWdEUUN3ME2zPVgvPDd{IN88US=> NEGxSIZUSU6JRWK=
HCC38 NXjSXms2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\qdmlEPTB;NECxMlU6OyEQvF2= MoHCV2FPT0WU
NCI-H69 M3PsXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nzVmlEPTB;NESxMlA5OyEQvF2= Mn;qV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

文献中の引用 (180)

Frequently Asked Questions

  • Question 1
    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

    Answer: You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • Question 2
    I would want to know if MK-2206 could cross the blood brain barrier?

    Answer: MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related Akt 阻害剤

  • Afuresertib (GSK2110183)

    Afuresertib (GSK2110183)は一種の有効的で、経口生物利用可能なAkt阻害剤で、Akt1、Akt2とAkt3に作用する時のKi値が0.08 nM、2 nMと2.6 nMそれぞれに分かれます。臨床2期。

  • AT13148

    AT13148は一種ATP競争性的で、多AGCキナーゼ経口阻害剤で、Akt1/2/3、p70S6K、PKAとROCKI/II的IC50値が38 nM/402 nM/50 nM、8 nM、3 nMと6 nM/4 nMそれぞれに分かれます。臨床1期。

  • SC79

    SC79は一種の大脳浸透性Aktリン酸化の活性剤で、一種のAkt-PHドメイン転位阻害剤です。

  • TIC10

    TIC10はAktとERKの活性を抑制し、Foxo3aでTRAILを誘導し、優れた薬特性をしています。TIC10は血液脳障壁を透せて、強い安定性と改善の薬物動態学性能を持っています。臨床1/2。

  • AZD5363

    AZD5363はAkt(Akt1/Akt2/3)の全ての亜型を有効に抑制し、無細胞試験で IC50値が3 nM/8 nM/8 nMそれぞれに分かれて、P70S6K/PKAに類似の抑制作用をしていますが、ROCK1/2に低い抑制活性を表します。臨床2期。

    Features:Moderate preclinical tolerability, and PD characteristics of an AKT inhibitor. Distinct profile from other AKT inhibitors in clinical development.

  • GDC-0068

    Ipatasertib (GDC-0068)は一種の高選択性のパン(pan)Akt阻害剤で、Akt1/2/3に作用して、無細胞試験でIC50値が 5 nM/18 nM/8 nMそれぞれに分かれて、PKAに作用する選択性より620倍が高くなります。臨床2期。

  • GSK690693

    GSK690693は一種のパン(pan)Akt阻害剤で、無細胞試験でAkt1/2/3に作用する時の IC50値が2 nM/13 nM/9 nMそれぞれに分かれます。GSK690693はAGCキナーゼ家族(PKA、PrkXとPKC)イソ酵素にも敏感です。臨床1期。

  • Perifosine (KRX-0401)

    Perifosine (KRX-0401)は一種の新たなAkt阻害剤で、MM.1S細胞の中で IC50値が4.7 μMになって、Aktのプレクストリンホモロジードメイン(pleckstrin homology domain)に作用します。臨床3期。

  • A-674563

    A-674563は一種のAkt阻害剤で、無細胞試験でKi値が11 nMになって、PKAに適合に有効していて、Akt1に作用する選択性がPKCに作用する選択性より30倍余り高くなります。

    Features:Orally bioavailable compound (achieved by replacing indole of A-443654 with phenyl moiety) and somewhat less selective for Akt over PKA than A-443654.

最近チェックしたアイテム

Tags: MK-2206 2HClを買う | MK-2206 2HCl供給者 | MK-2206 2HClを購入する | MK-2206 2HCl費用 | MK-2206 2HCl生産者 | オーダーMK-2206 2HCl | MK-2206 2HCl代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ