MK-2206 2HCl 化学構造
分子量: 480.39

高品質保証

文献中の引用(170)

カスタマーフィードバック(18)

Quality Control & MSDS

製品説明

  • Compare Akt Inhibitors
    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HClは高度選択的に Akt1, Akt2 and Akt3を抑制して、 IC50がそれぞれ 8 nM, 12 nM と 65 nMになる。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 M1rjTWN6fG:2b4jpZ{BCe3OjeR?= MnTRN{DPxE1? NHnONlY4OiCq M2XoeWROW09? MYTJcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdg>? NUXENW9zOjB3N{GwOlk>
A431 NEf2[ZJMcW6jc3WgRZN{[Xl? M4HtNFUh|ryP NYOyeYNIPSCq NHTPO|ZFVVOR NHqyO3VUfXCycnXzd4V{KHSqZTDzbYdv[Wyrbnegc4YhSWu2IHHu[EBGemt? MXuyNFU4OTB4OR?=
HepG2 M3vRSWN6fG:2b4jpZ{BCe3OjeR?= Mn;aNVAh|ryP M3\jSFI1KGh? NVrZVFd6TE2VTx?= MYTT[Y5{cXSrenXzJJJme2m|dHHueEBk\WyuczD0c{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDzc5Ji\mWwaXK= NIjtbZkzOTJyNUmyOS=>
Sk-Hep1 NF\EO2xEgXSxdH;4bYMhSXO|YYm= NX3xbGE6OTBizszN M{nLflI1KGh? MkDESG1UVw>? M{PYOHNmdnOrdHn6[ZMhemW|aYP0ZY51KGOnbHzzJJRwKHSqZTDjfZRwfG:6aXOg[YZn\WO2IH;mJJNwemGoZX7pZi=> M1;kflIyOjB3OUK1
OCUT1 cells harbored PIK3CA (H1047R+/+) NHHadXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnSe5E{KM7:TR?= NETPSZI2KGR? M{\CUmROW09? NX3CUHlpUUN3ME2wMlE1KM7:TR?= Mk\RNlEzQDl{Nke=
K1 cells harbored PIK3CA (E542K+/+) NVLCSoVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVezJO69VQ>? M4H1OVUh\A>? M2PWcWROW09? NWn2PGJYUUN3ME2wMlUzKM7:TR?= NUnxRlhIOjF{OEmyOlc>
FTC133 cells harbored PTEN (allele deletion and R130+) NVjFbmJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUOzJO69VQ>? NEW3SnM2KGR? MV7EUXNQ NGDye2FKSzVyPUCuNVgh|ryP MlzBNlEzQDl{Nke=
C643 cells harbored HRAS (G13R+/−) Ml7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\CN{DPxE1? MVW1JIQ> MljPSG1UVw>? MVLJR|UxRTBwMkeg{txO MWGyNVI5QTJ4Nx?=
Hth7 cells harbored NRAS (Q61R+/−) NFT5fG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\rdFMh|ryP MomxOUBl NHLFN|dFVVOR MmDOTWM2OD12LkWg{txO MoXNNlEzQDl{Nke=
TPC1 cells harbored RET/PTC1 rearrangement MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TFNVMh|ryP NYnnWmp[PSCm MljuSG1UVw>? Moe2TWM2OD1yLkW5JO69VQ>? MmKwNlEzQDl{Nke=
Hth74 NGnRO5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nNfVMh|ryP MUi1JIQ> MnLUSG1UVw>? NVjZbpY5UUN3ME2yMlE6KM7:TR?= NX7KcnBHOjF{OEmyOlc>
KAT18 M3GyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrDUoxWOyEQvF2= NGD1Ros2KGR? MXLEUXNQ MWPJR|UxRTRwNkKg{txO NGDWe4wzOTJ6OUK2Oy=>
SW1736 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvWNVAxKM7:TR?= Mk\lOUBl NWn1OY1{TE2VTx?= MlHTTWM2OD12Nz61OkDPxE1? NHrK[4QzOTJ6OUK2Oy=>
WRO NXn2T3ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGCwWo4yODByIN88US=> MlS3OUBl MlnPSG1UVw>? MYrJR|UxRjFyMECg{txO MnL1NlEzQDl{Nke=
TAD2 M1W4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;SNVAxOCEQvF2= M1PuUFUh\A>? MlTaSG1UVw>? NXL1UVZVUUN3ME6xNFAxKM7:TR?= NHLwR2EzOTJ6OUK2Oy=>
LN229 NIrkdnRCeG:ydH;zbZMhSXO|YYm= MX6wMlUh|ryP M2rzV|YxKGh? NXPwclYyTE2VTx?= NHTFfYJCfWevZX70d{BieG:ydH;n[Y5q[yCnZn\lZ5R{KG:oIHfl[ol1cW6rYh?= NY[3S4RzOjJyNUe5NVQ>
T98G M2DueGFxd3C2b4Ppd{BCe3OjeR?= MonZNE42KM7:TR?= NGXYPGE3OCCq MYDEUXNQ NYTrUFJlSXWpbXXueJMh[XCxcITv[4VvcWNiZX\m[YN1eyCxZjDn[YZqfGmwaXK= NGHvdXAzOjB3N{mxOC=>
HC11 NVHHbGpQTnWwY4Tpc44hSXO|YYm= NYPlN|UzOTBizszN MmrCNlQhcA>? MX;EUXNQ MmDTTY5pcWKrdIOg{tIu[2G|ZXnuJIFv\CCDRGLQJJN6dnSqZYPpdy=> NH7lT|gzOjR{Nk[yNS=>
MOLT-4 NEK1S|BEgXSxdH;4bYMhSXO|YYm= NYDGNmh2OTBizszN NInKeWQ1QCCq NInveHhFVVOR MVrJR|UxRTFwN,MAje69VQ>? NGPLbGwzOjZzNEK0Ny=>
CEM-R NHTDXmxEgXSxdH;4bYMhSXO|YYm= MmLCNVAh|ryP NG\nTpA1QCCq M2LFUmROW09? NFPTXGlKSzVyPUOuN-KBkc7:TR?= M4nJ[|IzPjF2MkSz
CEM-S M2K3XmN6fG:2b4jpZ{BCe3OjeR?= MUCxNEDPxE1? NEnoV|E1QCCq NHTMRZFFVVOR NEjKcI9KSzVyPUWuNgKBkc7:TR?= MXWyNlYyPDJ2Mx?=
MOLT-4 Mn7VSpVv[3Srb36gRZN{[Xl? NXm1b5p7OTBizszN MlvMNlQhcA>? M2fBZmROW09? NVzMNlVuSmyxY3vzJINmdGy|IHnuJJRp\SCJMD;HNUBxcGG|ZTDv[kB1cGViY3XscEBkgWOuZR?= NHLFZWMzOjZzNEK0Ny=>
MOLT-4 M13FZWZ2dmO2aX;uJGF{e2G7 NWjV[po5POLCid88US=> M{\4XFQhcA>? M3fObWROW09? MWrJcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFM1GvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> MVKyNlYyPDJ2Mx?=
CEM-R MlXmSpVv[3Srb36gRZN{[Xl? Mmn2OQKBkc7:TR?= NEfvToI1KGh? MlnESG1UVw>? M2KwRmlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFO0RU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? NE\GPI0zOjZzNEK0Ny=>
CEM-S M4iybGZ2dmO2aX;uJGF{e2G7 NFLUfHk16oDLzszN MnXHOEBp NE\2ZnlFVVOR NXHFUGVDUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|VCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ NGXxSIEzOjZzNEK0Ny=>
HepG2 cell MoLvT4lv[XOnIFHzd4F6 MU[yNEDPxE1? MlnoNlQhcA>? Moe5SG1UVw>? NGf5V5ZFd3ewcnXneYxifGW|IITo[UBxcG:|cHjvdplt[XSrb36gc4YhSUuW M3u5b|I{Pzl5M{G5
HepG2 cell M4DpNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPPOYw{OCEQvF2= MljRNlQhcA>? M3zNS2ROW09? M2rXemlvcGmkaYTzJINmdGxiZ4Lve5Rp NFfXO5YzOzd7N{OxPS=>
HepG2 cell NULRd2RbSXCxcITvd4l{KEG|c3H5 MmPXNlAh|ryP Mn7yNlQhcA>? MWDEUXNQ M4LxSWlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? NXfsT3BzOjN5OUezNVk>
GEO MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn1Soc2ODBibl2= NHLN[2Q4OiCq NHrje5pFVVOR NIr4ZYNKdmirYnn0d{Bk\WyuIHfyc5d1cA>? NUPHRYpCOjR3OEGyN|E>
CNE-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK1eGEyOCEQvF2= NXyzZ2p[QTZiaB?= NF;VZWtFVVOR M3ez[WlEPTB;Mj65OkDPxE1? MorGNlU{OzZ7MkW=
CNE-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoG0NVAh|ryP MlHqPVYhcA>? MUnEUXNQ MojpTWM2OD12LkWzJO69VQ>? NFjVT5czPTN|NkmyOS=>
HONE-1 NEXSRm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrOSHQyOCEQvF2= MoXZPVYhcA>? MYXEUXNQ MoiyTWM2OD1|LkO3JO69VQ>? NV73VYxLOjV|M{[5NlU>
SUNE-1 NVzCcWZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L6OlExKM7:TR?= NHvWc5k6PiCq M1jPfWROW09? M4W0XmlEPTB;MD61NkDPxE1? MnLyNlU{OzZ7MkW=
CNE-2 M3TXOmZ2dmO2aX;uJGF{e2G7 M2P1SlExKM7:TR?= M1\qXVQ5KGh? NXLlTmxDTE2VTx?= MWnJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy MmK3NlU{OzZ7MkW=
HONE-1 MXzGeY5kfGmxbjDBd5NigQ>? MXyxNEDPxE1? NF7tSYU1QCCq MmPISG1UVw>? M3;SNmlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhTzF? NFjMZWkzPTN|NkmyOS=>
NEC8 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLnTYRPUUN3ME2wMlA6PjVzIN88US=> MnTJV2FPT0WU
P12-ICHIKAWA Mn71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjBPVZvUUN3ME2wMlEyPjJizszN MkThV2FPT0WU
MDA-MB-175-VII Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMUO3N|gh|ryP MmTmV2FPT0WU
AsPC-1 M1LrZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XOUWlEPTB;MD6yNlEzOiEQvF2= MUjTRW5ITVJ?
T47D M1\tbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj6fWhKSzVyPUCuNlgzPSEQvF2= MlTYV2FPT0WU
HH MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7seYx{UUN3ME2wMlMxOjh|IN88US=> NYj4W3l4W0GQR1XS
MOLT-16 NWPTXVlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrVTWM2OD1yLkOwN|Ih|ryP MlPoV2FPT0WU
ES5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPsTWM2OD1yLkO0OFU2KM7:TR?= MnT5V2FPT0WU
RS4-11 M4TSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYO5dZV4UUN3ME2wMlM1PjFizszN MYrTRW5ITVJ?
KARPAS-45 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHTTWM2OD1yLkO3N|IyKM7:TR?= MWfTRW5ITVJ?
NCI-H720 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfrO2k6UUN3ME2wMlM4Pjd7IN88US=> NXjP[FNKW0GQR1XS
H9 NV\1dJU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[5dGp[UUN3ME2wMlM5QDh|IN88US=> NY\zXHN7W0GQR1XS
EFM-19 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHmTWM2OD1yLkS0NFEh|ryP M1HKfXNCVkeHUh?=
SBC-1 M3XHdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\Mdmt1UUN3ME2wMlQ1ODN3IN88US=> M17nWXNCVkeHUh?=
A4-Fuk Mn;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr0[4hXUUN3ME2wMlQ3QDZ6IN88US=> M2D4O3NCVkeHUh?=
NCI-H1563 NGLKU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf1UVVKSzVyPUCuOFgyQDlizszN NUHETYh{W0GQR1XS
HCC1419 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwNEi4PVIh|ryP NX\4Uo1NW0GQR1XS
H-EMC-SS M{\RWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDvVoxKSzVyPUCuOFk6OzlizszN NHmwboVUSU6JRWK=
BHT-101 MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3kNIlvUUN3ME2wMlUzQTZzIN88US=> M{X5XXNCVkeHUh?=
IGROV-1 MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:2TWM2OD1yLkW1NlQ6KM7:TR?= NUjNOHNtW0GQR1XS
HGC-27 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfETWM2OD1yLkW2O|g{KM7:TR?= NXfGdZp[W0GQR1XS
MDA-MB-361 NILxeo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXJXmtLUUN3ME2wMlU4PzZzIN88US=> NIfIeXZUSU6JRWK=
KE-37 M12yVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwNUiyOkDPxE1? NX\h[oFnW0GQR1XS
HCC70 NUX1TGZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwNUm4Nlch|ryP M1LHV3NCVkeHUh?=
LNCaP-Clone-FGC MkW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rpUGlEPTB;MD62NVA1QCEQvF2= NVGy[nZ7W0GQR1XS
HAL-01 NHLYcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;Mb|FMUUN3ME2wMlYzOTNizszN NFrpVWVUSU6JRWK=
HT NHrYem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwNkOyN|kh|ryP NXrQWpVIW0GQR1XS
MDA-MB-415 MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwNkO2NlYh|ryP MVrTRW5ITVJ?
NOS-1 NV;aTWpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn4N3FKSzVyPUCuOlM4OjNizszN MYXTRW5ITVJ?
DU-145 NUHKS2pHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNkS3OFUh|ryP NXP1e4tjW0GQR1XS
OCUB-M NV;HSG9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHDO5hKSzVyPUCuO|A6PjZizszN NUnqPWhjW0GQR1XS
VA-ES-BJ NW\yfVE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHRTWM2OD1yLkezNFI2KM7:TR?= MkCyV2FPT0WU
J-RT3-T3-5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELhcmZKSzVyPUCuO|Q1ODNizszN MXvTRW5ITVJ?
MOLT-4 NGG2TXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwOEC1PFIh|ryP M1jndXNCVkeHUh?=
NB7 NGTpbGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTRTWM2OD1yLkiyOFEyKM7:TR?= NGL2U4pUSU6JRWK=
L-363 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH34UmFKSzVyPUCuPFM1PDJizszN MV\TRW5ITVJ?
NKM-1 MnPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT4cVFKSzVyPUCuPFYzPTNizszN MWHTRW5ITVJ?
HOP-92 NEOwO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;OTWM2OD1yLki3NlI{KM7:TR?= M1\ne3NCVkeHUh?=
OAW-42 NYXQZ2k{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwOEi3NkDPxE1? M{\5d3NCVkeHUh?=
HuO9 M4GxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Cyc2lEPTB;MD65Nlc2OSEQvF2= MmDBV2FPT0WU
MFE-280 NU\ISIdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwOU[0OlUh|ryP NGT4WmpUSU6JRWK=
EM-2 M{e0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MluwTWM2OD1yLkm3PVM6KM7:TR?= MVTTRW5ITVJ?
NCI-H520 MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHIdnJKSzVyPUCuPVg2QTJizszN MlvzV2FPT0WU
LB2241-RCC MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH75OWVKSzVyPUCuPVk4OzRizszN M4nufXNCVkeHUh?=
SK-NEP-1 MoL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrOfVJLUUN3ME2xMlE1PDh3IN88US=> NXPhNJMzW0GQR1XS
LXF-289 NYHkPWd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPXRVhKSzVyPUGuNVcyPTZizszN M3vnNnNCVkeHUh?=
EPLC-272H NGjs[4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDLUnhKSzVyPUGuNVczPTZizszN NXK1[pN{W0GQR1XS
COLO-684 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWW1UlRiUUN3ME2xMlI{PzJ3IN88US=> MYXTRW5ITVJ?
ES1 M365Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkCyTWM2OD1zLkK0NFY2KM7:TR?= MnexV2FPT0WU
DOHH-2 MoLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm0U2ozUUN3ME2xMlI5OjB|IN88US=> NXLqS5hMW0GQR1XS
CTB-1 M33MWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3P4U2lEPTB;MT6yPFk6KM7:TR?= MXLTRW5ITVJ?
G-401 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTMTWM2OD1zLkK5O|k2KM7:TR?= MVHTRW5ITVJ?
LoVo NWjwZ|IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFwM{K1N|Qh|ryP NFPCcXJUSU6JRWK=
Ramos-2G6-4C10 M4CwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELrPXRKSzVyPUGuN|M4ODFizszN MkXGV2FPT0WU
MFM-223 NUPudnpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmG3TWM2OD1zLkO0OFYyKM7:TR?= MYTTRW5ITVJ?
PA-1 Ml\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f5UmlEPTB;MT6zOVI3PSEQvF2= NH7SPZlUSU6JRWK=
697 NXvjOJVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zZPGlEPTB;MT6zO|YyPiEQvF2= NFO2W4NUSU6JRWK=
QIMR-WIL M1rEWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XncGlEPTB;MT60PVEyPiEQvF2= NX3VfHB2W0GQR1XS
HOS MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTFwNEm1OVgh|ryP NETab2FUSU6JRWK=
DMS-273 NFjkfFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTFwNUG5OVkh|ryP NYradW1nW0GQR1XS
ME-180 NE\FS2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzITopKSzVyPUGuOVY5QTFizszN NIrjbIdUSU6JRWK=
HCC2218 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfWTWM2OD1zLk[4NlI2KM7:TR?= MVXTRW5ITVJ?
CAL-54 MlfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUWyNo9JUUN3ME2xMlcyOjR{IN88US=> MnH0V2FPT0WU
OMC-1 M33PbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37HcGlEPTB;MT63OFY4PyEQvF2= NHKzU2pUSU6JRWK=
COR-L105 MmrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTxT21KSzVyPUGuO|k4OzdizszN M33h[XNCVkeHUh?=
BV-173 NUDxTGg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7WcWpKSzVyPUGuPFExPzRizszN NFHH[VRUSU6JRWK=
RKO NHS2WHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLnclVSUUN3ME2xMlg4OTBzIN88US=> NX3LdndSW0GQR1XS
SNU-387 NX7IboM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\xVWlEPTB;MT64PFQxPiEQvF2= M2rTN3NCVkeHUh?=
SW1088 M{LzUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwOUS2NFYh|ryP M2Do[XNCVkeHUh?=
Hs-578-T M4qxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJwMUG0N|Mh|ryP Mo\uV2FPT0WU
OC-314 NGjkd3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFexW3FKSzVyPUKuNVUxQDZizszN NX33VYpkW0GQR1XS
RMG-I MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETCNHVKSzVyPUKuNVY{QThizszN MU\TRW5ITVJ?
NCI-H1395 MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;qTWM2OD1{LkG4NFkyKM7:TR?= MXfTRW5ITVJ?
GAMG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJwMkO4OFUh|ryP NGrmRWpUSU6JRWK=
LB1047-RCC NIO3RWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHO[mhKSzVyPUKuNlQ{OTdizszN M2TKdnNCVkeHUh?=
MN-60 NVHmSYNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXRNnc{UUN3ME2yMlI6QTJ|IN88US=> MULTRW5ITVJ?
OAW-28 NUn5N4ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\qTWM2OD1{LkK5PVUyKM7:TR?= NYLCSI0zW0GQR1XS
NCI-H2228 NVvpbYVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDLOplbUUN3ME2yMlMyPTV{IN88US=> M335d3NCVkeHUh?=
ABC-1 NEDkS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3BbHQxUUN3ME2yMlM{OjV|IN88US=> NYfJTHhzW0GQR1XS
LS-513 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmS0TWM2OD1{LkOzOFg1KM7:TR?= NFq1SnlUSU6JRWK=
KS-1 MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz3WoZKSzVyPUKuN|gyQTFizszN MYjTRW5ITVJ?
NB69 MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX34NFZzUUN3ME2yMlM5QTh|IN88US=> MV7TRW5ITVJ?
VM-CUB-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP0cZRKSzVyPUKuN|kxQDNizszN NWS1R3Y{W0GQR1XS
D-423MG Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoT5TWM2OD1{LkSxNFQ1KM7:TR?= MVHTRW5ITVJ?
EW-18 M4PLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfnTWM2OD1{LkSxPVM6KM7:TR?= NHLIXJNUSU6JRWK=
YH-13 M1XGe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TxeWlEPTB;Mj60OlE2OyEQvF2= NYK2b|ZNW0GQR1XS
T-24 M1zWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrQWG1JUUN3ME2yMlQ4QDhzIN88US=> NHj1NXpUSU6JRWK=
ES8 NYL6eIQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzxTWM2OD1{LkS5Nlg4KM7:TR?= MX\TRW5ITVJ?
ES3 NX25Wm5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nMSGlEPTB;Mj60PVc2QSEQvF2= MnXrV2FPT0WU
RXF393 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnSTWM2OD1{Lk[wOFg4KM7:TR?= MVXTRW5ITVJ?
RPMI-8226 Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjKTWM2OD1{Lk[yPVU{KM7:TR?= M3PwOHNCVkeHUh?=
AGS M3:yOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwN{KxN|ch|ryP NHHFcWZUSU6JRWK=
HCC1395 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfreY1bUUN3ME2yMlc2OTh5IN88US=> NGflUYVUSU6JRWK=
MV-4-11 Mni2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJwN{WyOlYh|ryP NHjLdJNUSU6JRWK=
A204 NIjSO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJwOEO4O|Ih|ryP Mn\tV2FPT0WU
MCF7 MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWyVWtKSzVyPUKuPFYyOTdizszN M361U3NCVkeHUh?=
SNU-423 NIHPdZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLuTWM2OD1{Lki5NlQzKM7:TR?= NFv4epdUSU6JRWK=
NCI-H1048 MlK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXNTWM2OD1{Lkm2PFY2KM7:TR?= Mlr5V2FPT0WU
GR-ST MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTNwMES2NVEh|ryP M4j6[3NCVkeHUh?=
EoL-1- NVm3V|BjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfxTWM2OD1|LkC3NFU5KM7:TR?= M{fibXNCVkeHUh?=
HuH-7 MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXqN5dLUUN3ME2zMlA6PDZ2IN88US=> M{XadnNCVkeHUh?=
OS-RC-2 M3zrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnziTWM2OD1|LkGxNVkh|ryP NWe0eWhjW0GQR1XS
EW-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS3O2ZKSzVyPUOuNVk2OjlizszN MoXnV2FPT0WU
NCI-H747 NVHQTJBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TON2lEPTB;Mz6yNFY6PCEQvF2= NWO3dIMzW0GQR1XS
EW-16 MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H2d2lEPTB;Mz6yNVg4QSEQvF2= MXfTRW5ITVJ?
DOK NVfCUZVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Ls[GlEPTB;Mz6yNlg2QSEQvF2= MoPZV2FPT0WU
HCC2157 NGGyOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO3W25KUUN3ME2zMlM5OTd7IN88US=> NYThcmlFW0GQR1XS
OVCAR-3 NWL6TpVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXwTWM2OD1|LkSwO|g3KM7:TR?= MYjTRW5ITVJ?
NCI-H1623 M{DyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L6fGlEPTB;Mz60NVIzPCEQvF2= MWrTRW5ITVJ?
H4 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f6XmlEPTB;Mz60OVYzPiEQvF2= MoPEV2FPT0WU
SW1710 NX[2RnR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYC2[YRMUUN3ME2zMlQ3Pjd6IN88US=> M3GyRnNCVkeHUh?=
RT-112 NIrpcnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3oSmxKSzVyPUOuOVI{QDhizszN NH;wTGhUSU6JRWK=
DMS-114 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTNwNkKyO|gh|ryP M{LJT3NCVkeHUh?=
AN3-CA NEe1fmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDG[4lKSzVyPUOuOlI1PTZizszN NXjGSIJ1W0GQR1XS
KNS-62 NETDeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHOdpl3UUN3ME2zMlY{OzN6IN88US=> M{LCdXNCVkeHUh?=
SJRH30 NX;DTndKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTNwNkmxNlIh|ryP MmT0V2FPT0WU
G-402 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzvTWM2OD1|LkewO|EyKM7:TR?= M1Htb3NCVkeHUh?=
MHH-PREB-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PCWWlEPTB;Mz63NlA{QCEQvF2= NFzxTlNUSU6JRWK=
P30-OHK MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTNwOEC5O|Yh|ryP NFjPcmNUSU6JRWK=
RVH-421 MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\rd|dVUUN3ME2zMlgyPzh6IN88US=> MXXTRW5ITVJ?
LU-134-A M2HRT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnHc3BIUUN3ME2zMlg5PDJ6IN88US=> MUDTRW5ITVJ?
ECC10 NILvUG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETSSo5KSzVyPUOuPVM3OjJizszN NXzrVGZiW0GQR1XS
TGW MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m4PGlEPTB;ND6wNlMxPSEQvF2= NVKzWppFW0GQR1XS
MLMA NWeyNWx7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\QdGlEPTB;ND6wNlk3PiEQvF2= M4\FfnNCVkeHUh?=
SCC-25 MljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S3b2lEPTB;ND6wOlU3PiEQvF2= MWXTRW5ITVJ?
TYK-nu M4jyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTRwMEm1N|Qh|ryP MVnTRW5ITVJ?
LAMA-84 NIr6[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTRwMUSxPVEh|ryP M37lfHNCVkeHUh?=
Calu-3 NWTTOXlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHQNpNKSzVyPUSuNlQ1OTZizszN MoLPV2FPT0WU
NCI-H460 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTRwMk[0OFMh|ryP NHTme5FUSU6JRWK=
EGI-1 Mnq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnhfmhKSzVyPUSuN|c4PzhizszN M1:wenNCVkeHUh?=
NCI-H292 MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTRwM{ixOFYh|ryP MVrTRW5ITVJ?
HCE-T MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OyRmlEPTB;ND60NVU4QSEQvF2= M4DyUHNCVkeHUh?=
EW-11 NHL1VJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHG0dYJKSzVyPUSuOFE5OzhizszN M2fWRnNCVkeHUh?=
ATN-1 M4X6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Twb2lEPTB;ND60OFMxPCEQvF2= M3SycnNCVkeHUh?=
NB5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\ue2lEPTB;ND61N|Y6PyEQvF2= MnixV2FPT0WU
KLE NHTScGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTRwN{CxPVgh|ryP NV7nXFI2W0GQR1XS
CAL-39 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTRwN{KxOFYh|ryP Ml:yV2FPT0WU
TI-73 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTRwOEC2NFkh|ryP NXPGPJU1W0GQR1XS
HO-1-N-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTjTWM2OD12Lkm0NkDPxE1? Mm\pV2FPT0WU
786-0 NVvBWldOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj1TWM2OD12Lkm0Olc{KM7:TR?= NETnTmNUSU6JRWK=
SK-N-DZ MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfTTWM2OD12Lkm2NVQzKM7:TR?= Ml\zV2FPT0WU
NCI-H446 NEXUcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjacHhKSzVyPUWuNlAxODlizszN NH;1O3BUSU6JRWK=
ETK-1 MkLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnL[oR4UUN3ME21MlIyOTZ3IN88US=> NEPrbppUSU6JRWK=
BT-20 NX;qO3NGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn0TWM2OD13LkKxN|U{KM7:TR?= NGXIc3NUSU6JRWK=
MEL-HO M3v3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD5TWM2OD13LkO3N|M3KM7:TR?= NVvPXlNiW0GQR1XS
CAL-27 NGrlSFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\ZdFlTUUN3ME21MlQ3OzN7IN88US=> MoHpV2FPT0WU
SW872 NYLMRmtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln3TWM2OD13LkW5OFI5KM7:TR?= MnLSV2FPT0WU
RPMI-2650 NXv1SolYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTVwNk[xPVkh|ryP NXXEc5ExW0GQR1XS
PFSK-1 NFL0WVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTVwN{K3N|Ih|ryP MVPTRW5ITVJ?
SF295 NFz3OpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLldmxKSzVyPUWuPFA3OzNizszN NHvsZXJUSU6JRWK=
Becker NWnlTJI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTVwOE[0O|Ih|ryP NHXwe45USU6JRWK=
Saos-2 Ml3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTVwOE[1N{DPxE1? NGS5[3lUSU6JRWK=
SK-OV-3 NXr0WGcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnm5TWM2OD13Lkm5PFE3KM7:TR?= M2ezc3NCVkeHUh?=
VMRC-RCZ Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LXUGlEPTB;Nj6wPFc4OyEQvF2= M4LodnNCVkeHUh?=
EW-22 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTZwMUm2OFkh|ryP MmG2V2FPT0WU
BT-474 MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf4d|RNUUN3ME22MlI{OyEQvF2= M17aZnNCVkeHUh?=
BFTC-909 NWHieFIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDMTWM2OD14LkOwN|Q2KM7:TR?= M2\ve3NCVkeHUh?=
NB12 NXviPWQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrCb|hMUUN3ME22MlM6ODdzIN88US=> MYrTRW5ITVJ?
D-263MG M4jafGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTZwNEWxOlkh|ryP MUnTRW5ITVJ?
SNB75 M3;pOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPPUZZ3UUN3ME22MlYxOTR|IN88US=> MYjTRW5ITVJ?
A704 M1e5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jESWlEPTB;Nj62N|A3KM7:TR?= NIDNPYtUSU6JRWK=
NCI-H1693 MnPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTZwNkO2NFQh|ryP MV\TRW5ITVJ?
LN-405 MoW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTZwN{m2O|Ih|ryP MV;TRW5ITVJ?
CHL-1 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTZwOECwO|kh|ryP NFvXXXhUSU6JRWK=
A498 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvjTWM2OD14LkixPVYyKM7:TR?= M2j5cHNCVkeHUh?=
TE-12 M2H6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPFe413UUN3ME22Mlg{QDF5IN88US=> NX;WWlJGW0GQR1XS
TE-6 MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rNTWlEPTB;Nj65N|A{QCEQvF2= NFrHZ2lUSU6JRWK=
AU565 NInobHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrBTWM2OD14Lkm2PVU4KM7:TR?= MVjTRW5ITVJ?
RD MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfI[pFGUUN3ME22Mlk5Ojh2IN88US=> MV\TRW5ITVJ?
SW1463 M{i4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:1TWM2OD15LkGxNVY5KM7:TR?= M{TZRnNCVkeHUh?=
LU-99A NH3leY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTCd2xKSzVyPUeuNVQ{OjJizszN Mn3vV2FPT0WU
NCI-H28 M2TOb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrTcVkzUUN3ME23MlI6OjRizszN NFvWW2JUSU6JRWK=
MC-IXC NVK0SZdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTdwNEi1O|Yh|ryP NGfweXlUSU6JRWK=
GP5d NIrJepJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnsR2g4UUN3ME23MlQ5PzZ2IN88US=> NHOybZZUSU6JRWK=
GB-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXBTWM2OD15LkW0PFA1KM7:TR?= MX\TRW5ITVJ?
CAL-33 NWfiZlNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvMV|hKSzVyPUeuOlYzOzNizszN MXHTRW5ITVJ?
MSTO-211H NEDuWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XBc2lEPTB;Nz62O|M{PiEQvF2= M{DrdXNCVkeHUh?=
TE-5 NE\U[YJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfKTWM2OD15Lke5N|M1KM7:TR?= MoPLV2FPT0WU
D-566MG NGDVTYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3STWM2OD16LkC0OFI6KM7:TR?= NFHQNo5USU6JRWK=
JVM-3 NXPjRmFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorQTWM2OD16LkG1NlY5KM7:TR?= M4PEVXNCVkeHUh?=
T98G MoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W1S2lEPTB;OD6xPFA3PyEQvF2= MUTTRW5ITVJ?
HCC1954 MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XuW2lEPTB;OD60OVExPCEQvF2= MWLTRW5ITVJ?
SF126 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRThwNEW5N|Yh|ryP NYftW4syW0GQR1XS
LB996-RCC NV31WnVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rUfWlEPTB;OD61N|I2PyEQvF2= M1\1b3NCVkeHUh?=
SKG-IIIa MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TlWWlEPTB;OD62N|A3QSEQvF2= Mme2V2FPT0WU
NCI-SNU-1 MmXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHLXFZKSzVyPUiuOlQ3PDNizszN NVPTVFdQW0GQR1XS
LB771-HNC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vG[GlEPTB;OD62OFY6PiEQvF2= NXuyZpViW0GQR1XS
SCC-4 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRThwNkiyNVkh|ryP MljqV2FPT0WU
CAMA-1 Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonOTWM2OD16Lke3NVQ3KM7:TR?= MVrTRW5ITVJ?
D-502MG M4O4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIX4NYJKSzVyPUiuO|g3OjlizszN NXX1bJRTW0GQR1XS
ESS-1 MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG3bnRFUUN3ME24Mlg5PzB2IN88US=> NGjVVY1USU6JRWK=
HEC-1 M3WwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfsTWM2OD16Lki5PFY3KM7:TR?= NGLZTZlUSU6JRWK=
NB10 M33DTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPCTFZKSzVyPUmuNFIzOjRizszN Ml\wV2FPT0WU
8505C NYTPNHh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG1foVKSzVyPUmuNFQzOzJizszN NUHtboNvW0GQR1XS
EFO-27 Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTlwMU[0NVIh|ryP M4PHc3NCVkeHUh?=
HN M4S3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTlwMU[2Nlgh|ryP MlvsV2FPT0WU
DSH1 M3XxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTlwMkC4O{DPxE1? NWPsOZBIW0GQR1XS
NBsusSR MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnHWpFKSzVyPUmuNlc1ODJizszN MXnTRW5ITVJ?
LS-123 NIPVWlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37C[mlEPTB;OT6zNVc3OSEQvF2= NEjrdG1USU6JRWK=
SHP-77 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzZSVVTUUN3ME25MlM6QTN3IN88US=> NG\WenBUSU6JRWK=
ACN NV3BfZFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nDcWlEPTB;OT61N|I4PyEQvF2= M2TNSXNCVkeHUh?=
U251 NVu4WHdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTUTZNHUUN3ME25MlY2PTR2IN88US=> NHzmSXhUSU6JRWK=
A431 NGiyTVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnHbI4zUUN3ME25MlgxOjN6IN88US=> M2\HdnNCVkeHUh?=
5637 MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnsXYdKSzVyPUmuPFQ6QDRizszN M3rjO3NCVkeHUh?=
MDA-MB-157 M1;FVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfXdmx7UUN3ME25MlkzQDd6IN88US=> NFWxc2RUSU6JRWK=
A101D MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r2WmlEPTB;OT65PVk4PCEQvF2= NGjqcI1USU6JRWK=
YKG-1 MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPQbYFjUUN3ME2xNE4zODB4IN88US=> MlW5V2FPT0WU
LAN-6 NEOxc|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFyLkKxOlQh|ryP MVjTRW5ITVJ?
OVCAR-5 M1OzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:xTnJKSzVyPUGwMlI1OzNizszN NW\DN4czW0GQR1XS
A549 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTFyLkO5O|Mh|ryP M1\xbnNCVkeHUh?=
no-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTFyLkSzOVMh|ryP NF7GbXZUSU6JRWK=
SF539 NULoXGJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfZcIRnUUN3ME2xNE46ODRzIN88US=> MXjTRW5ITVJ?
A388 M3LHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFzLkO4PVch|ryP NHPHVWhUSU6JRWK=
DEL MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXTTWM2OD1zMT60NlQh|ryP MnW2V2FPT0WU
SW954 M4KzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTFzLkS2Olgh|ryP NG\qWHFUSU6JRWK=
TK10 NHfMZ5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zlVmlEPTB;MUGuOVI4OSEQvF2= NH[zWmFUSU6JRWK=
SW756 M2\uOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnUTWM2OD1zMT61Nlk1KM7:TR?= M{XpcXNCVkeHUh?=
PC-3 NH\MVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTFzLkW3OlQh|ryP MmrIV2FPT0WU
ONS-76 NFrQW3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmroTWM2OD1zMT62N|Yh|ryP NIG3N2lUSU6JRWK=
A427 NEfKbmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzjUJl{UUN3ME2xNU44ODl|IN88US=> NH\oR49USU6JRWK=
MEG-01 NEi1[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\qUmlEPTB;MUGuO|UxQSEQvF2= NUTpfndxW0GQR1XS
BB30-HNC NWHxTYEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIToOZdKSzVyPUGxMlc6QDJizszN MVjTRW5ITVJ?
NCI-H1299 M{nwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHUTWM2OD1zMT64NFk{KM7:TR?= MXrTRW5ITVJ?
GCT MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfqTWM2OD1zMT64NlI5KM7:TR?= NIjFeINUSU6JRWK=
D-247MG M3rneWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DzbmlEPTB;MUGuPVY3OyEQvF2= NXn2d4NRW0GQR1XS
CFPAC-1 NFnwbllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;GRWlEPTB;MUGuPVc5OiEQvF2= NIW3UZlUSU6JRWK=
EKVX MmHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHOeJFxUUN3ME2xNk4xOzF|IN88US=> NXK3d|JDW0GQR1XS
CAL-51 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDkNVJKSzVyPUGyMlA4OTZizszN MknwV2FPT0WU
BB49-HNC M3fPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe0SphKSzVyPUGyMlEyPzdizszN NX3QbmN3W0GQR1XS
RPMI-7951 MoXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;2TWM2OD1zMj6xPFU1KM7:TR?= M161S3NCVkeHUh?=
RH-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIX3UY9KSzVyPUGyMlIyQDRizszN NV7uS|h7W0GQR1XS
BCPAP Mkf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjrWGxJUUN3ME2xNk41PzR7IN88US=> MYPTRW5ITVJ?
GCIY NF\NXYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF{LkWyNFkh|ryP NXfp[nlpW0GQR1XS
KNS-81-FD NWjoVo9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXPTHdKSzVyPUGyMlU5PjlizszN MlPTV2FPT0WU
KYSE-140 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjBZVBKSzVyPUGyMlg2QTVizszN NU\EbIgxW0GQR1XS
Ca-Ski MljjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTD[IN{UUN3ME2xNk46ODRzIN88US=> MkPlV2FPT0WU
TGBC1TKB NEj3U5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHHVndoUUN3ME2xNk46OTF3IN88US=> M3LSNHNCVkeHUh?=
HCC1187 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTJXJFMUUN3ME2xN{4yQTF{IN88US=> MoHJV2FPT0WU
SJSA-1 M3zJVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLibY1SUUN3ME2xN{4zOzJ5IN88US=> MoTZV2FPT0WU
CTV-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zGZmlEPTB;MUOuN|Q2KM7:TR?= MmX0V2FPT0WU
WM-115 NUTIcpJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PINGlEPTB;MUOuOlQ5OyEQvF2= M4fPbnNCVkeHUh?=
CHP-212 NIX3PFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTF|Lkm3N|kh|ryP M3LHVnNCVkeHUh?=
SCC-15 NXrD[lExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnaVndKSzVyPUGzMlk4PzVizszN MV3TRW5ITVJ?
BPH-1 NX\jNY9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3ZTWM2OD1zND6xOlY1KM7:TR?= MorXV2FPT0WU
SW780 NGjTUFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;iVHpKSzVyPUG0MlUxOjVizszN MkTVV2FPT0WU
NCI-H2291 NVq5[YhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv4e4RGUUN3ME2xOE42QDd6IN88US=> NVHReWlmW0GQR1XS
JEG-3 M{n0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XSWmlEPTB;MUSuOlMzPiEQvF2= NEn2bJJUSU6JRWK=
CAL-120 NGLvRllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnOZ3lnUUN3ME2xOE44ODJ5IN88US=> MUjTRW5ITVJ?
NCI-H23 NVzyOWxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETjRWJKSzVyPUG0Mlc6QTdizszN M2T4NXNCVkeHUh?=
MS-1 M{TDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHs[2RKSzVyPUG0Mlk3OTFizszN M3T3VXNCVkeHUh?=
PC-14 NFn1eVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vuNWlEPTB;MUSuPVY2PCEQvF2= M3jPbXNCVkeHUh?=
D-283MED M4PWVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHxPFBKSzVyPUG1MlAyOTFizszN MV3TRW5ITVJ?
OE19 M3;L[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTF3LkG1OFEh|ryP NWTRW5FLW0GQR1XS
CAS-1 Mk\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTF3LkSxPFQh|ryP Ml7uV2FPT0WU
NCI-H727 NFz6To1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF3LkSyNlEh|ryP MoLWV2FPT0WU
SiHa M1rZRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq5[W1jUUN3ME2xOU44PTl2IN88US=> MmruV2FPT0WU
BFTC-905 NWDzT4VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrIWnlKSzVyPUG1Mlc3QTRizszN NWLHeZduW0GQR1XS
MDA-MB-453 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnxOFU2UUN3ME2xOk4yPjR{IN88US=> MmL0V2FPT0WU
HuP-T3 NF\BT29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfSUWFnUUN3ME2xOk43Ozd|IN88US=> Mlm5V2FPT0WU
SK-LU-1 M3HhVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\VS5VKSzVyPUG2MlY6PTZizszN MVrTRW5ITVJ?
Detroit562 Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fjO2lEPTB;MU[uO|MyQCEQvF2= MnvLV2FPT0WU
HCC1569 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rxcGlEPTB;MU[uPFM{PyEQvF2= NED0PVZUSU6JRWK=
SK-MES-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjmTWM2OD1zNj64OFE6KM7:TR?= NHnuTZBUSU6JRWK=
BB65-RCC M3LXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoC1TWM2OD1zNz6wOFc6KM7:TR?= MVvTRW5ITVJ?
LOXIMVI NWT1[XBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzZc|JyUUN3ME2xO{4xPzB5IN88US=> MYPTRW5ITVJ?
SW1783 NUfUe4xqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\PTWM2OD1zNz6xNlgh|ryP M{fh[3NCVkeHUh?=
NH-12 MmTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXVN3ZKSzVyPUG3MlM{ODNizszN NHe3XlhUSU6JRWK=
UACC-257 NEDzd2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj0XnoyUUN3ME2xO{42PTF{IN88US=> NIHSXo1USU6JRWK=
KOSC-2 NGfFPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnOV4pLUUN3ME2xO{43PzV5IN88US=> MoDTV2FPT0WU
KG-1 NVPJb21vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzDfpI6UUN3ME2xO{43QTN5IN88US=> M1XPSnNCVkeHUh?=
M059J M3HU[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qwPWlEPTB;MUeuO|A{KM7:TR?= NWrSSYpTW0GQR1XS
MHH-NB-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnHZ4VKSzVyPUG3Mlk3PzNizszN MXTTRW5ITVJ?
EW-1 NUjJSnpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXywW5RlUUN3ME2xPE4yOzh{IN88US=> NVfobGhEW0GQR1XS
CAL-85-1 NEPwXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq4TWM2OD1zOD6yN|U4KM7:TR?= MoT0V2FPT0WU
639-V MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX70TVF2UUN3ME2xPE4{OzV2IN88US=> MkLqV2FPT0WU
C32 M2nEXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfNc3pKSzVyPUG4MlQ4OjdizszN NHL3SGVUSU6JRWK=
KM-H2 MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTNSJFKSzVyPUG4MlUzOzJizszN MVrTRW5ITVJ?
A253 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWOzOpo{UUN3ME2xPE44Ojh4IN88US=> NV64e4t1W0GQR1XS
NCI-N87 NWPZZ|ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nDe2lEPTB;MUiuPVAxQCEQvF2= NFzxOGlUSU6JRWK=
8-MG-BA MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHHTWM2OD1zOT6wOlQ3KM7:TR?= NHLl[pBUSU6JRWK=
GI-ME-N NGrDeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrmTWM2OD1zOT6xOVQ3KM7:TR?= NXLufZhTW0GQR1XS
8305C MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HMc2lEPTB;MUmuNlI5PiEQvF2= MYXTRW5ITVJ?
TE-8 M{TpSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTF7LkOwNlQh|ryP MojLV2FPT0WU
KYSE-270 M37WW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJyLkCyNVch|ryP MVTTRW5ITVJ?
HL-60 MnLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDvWVJKSzVyPUKwMlA6PDFizszN M{D0[nNCVkeHUh?=
Mo-T NW\Xemp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJyLkG2OlUh|ryP M13JT3NCVkeHUh?=
NCI-H1355 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDwbVk6UUN3ME2yNE4{Ozd2IN88US=> NYrMVXI{W0GQR1XS
HT-1080 NFn0b3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPpV5VKSzVyPUKwMlU1QTdizszN NXj2OZVzW0GQR1XS
MIA-PaCa-2 NUHiNmZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3ncWZKSzVyPUKwMlY5QDNizszN M1fWN3NCVkeHUh?=
NCI-H441 MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXG0V25{UUN3ME2yNE44Ozd7IN88US=> NYq1PFhUW0GQR1XS
LCLC-97TM1 NF;0W3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXGTWM2OD1{MD64NVM1KM7:TR?= MnPUV2FPT0WU
HT-3 NEfCS4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjGTWpNUUN3ME2yNU42PjNzIN88US=> NIj6bFFUSU6JRWK=
22RV1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XwTGlEPTB;MkGuOVY5PSEQvF2= NYi1fXJzW0GQR1XS
LK-2 M4DDTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr3flZYUUN3ME2yNU42QTV|IN88US=> Moj0V2FPT0WU
CW-2 NVjoOoJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy3cYxLUUN3ME2yNU43ODZ7IN88US=> Ml;GV2FPT0WU
KYSE-510 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJzLk[wPVUh|ryP NWnjWHp7W0GQR1XS
CGTH-W-1 M2rWTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJzLkexOlYh|ryP M1mzb3NCVkeHUh?=
NCI-H661 MoHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnSOmU1UUN3ME2yNk4xOzRizszN NXPQcVlxW0GQR1XS
KU-19-19 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M332VWlEPTB;MkKuNVY6PyEQvF2= NYraVm8{W0GQR1XS
NCI-H2122 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJ{LkK0N|Ih|ryP NHq1d3RUSU6JRWK=
NCI-H526 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJ{LkO4PVUh|ryP MlnvV2FPT0WU
NCI-H1650 NUTtTlhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHwTWM2OD1{Mj63OlQh|ryP MlH1V2FPT0WU
AM-38 M4LKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LifWlEPTB;MkKuPFY5QSEQvF2= MVTTRW5ITVJ?
NCI-H2405 NEDoUY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGwXoY{UUN3ME2yN{4zPTN|IN88US=> MnvLV2FPT0WU
M14 M3P0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJ|LkSwPFgh|ryP MXXTRW5ITVJ?
ES4 M2LWOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJ|LkSyN|Ih|ryP MXfTRW5ITVJ?
DJM-1 NEnaUnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPvSWFKSzVyPUKzMlUzOzRizszN MWPTRW5ITVJ?
S-117 M1PZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTJ|Lke2OVEh|ryP MnnzV2FPT0WU
MZ2-MEL M4DSSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvWbohrUUN3ME2yN{44PzV7IN88US=> NGPCeplUSU6JRWK=
SK-MEL-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W4ZWlEPTB;MkOuPFE{OyEQvF2= M121SnNCVkeHUh?=
HCC1806 NGK1T3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTUTWM2OD1{Mz64O|A6KM7:TR?= MmfhV2FPT0WU
NMC-G1 M37le2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJ2LkKyNlYh|ryP M4DhPHNCVkeHUh?=
DK-MG M1fUV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LifmlEPTB;MkSuNlk1KM7:TR?= NXjJbZNOW0GQR1XS
SK-N-FI NIHQdIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXoT2RKSzVyPUK0MlM{ODJizszN M3vrN3NCVkeHUh?=
KINGS-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJ2LkS4O|Qh|ryP MkmxV2FPT0WU
HCC2998 MlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJ2LkS4PFUh|ryP Mn3PV2FPT0WU
ALL-PO NXvZfpVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjjUmZKSzVyPUK0MlYyQSEQvF2= NVPoOYRYW0GQR1XS
MPP-89 M16weWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJ3LkC0OVgh|ryP NWnWUI5zW0GQR1XS
NCI-H2342 NWHJcoRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJ3LkG5OVMh|ryP NVPN[ZI6W0GQR1XS
TE-1 MonoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrVTWM2OD1{NT6zOVY{KM7:TR?= MVPTRW5ITVJ?
RH-18 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHhTIVzUUN3ME2yOU42QTF6IN88US=> NH;JWG5USU6JRWK=
HT-1376 NU\ubooyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmS1TWM2OD1{NT62OFY2KM7:TR?= M4LZVnNCVkeHUh?=
U-2-OS NEDNfZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4W3fGlEPTB;MkWuOlg5QCEQvF2= M2[3fnNCVkeHUh?=
BT-549 NILnRYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nob2lEPTB;MkWuPVAyOSEQvF2= M1jnR3NCVkeHUh?=
NCI-H1755 Mki2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\Ib|BiUUN3ME2yOU46QTR3IN88US=> M2LB[XNCVkeHUh?=
EW-13 NUW0T49WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS1XJBKSzVyPUK2MlAzPzRizszN M2fnRnNCVkeHUh?=
NB13 NYO2bmtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPk[IlKSzVyPUK2MlA6PDlizszN M3TEZ3NCVkeHUh?=
NUGC-3 NXXCPYFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nNZWlEPTB;Mk[uNlExOyEQvF2= MmXmV2FPT0WU
GMS-10 M3;EO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrNdI1IUUN3ME2yOk4zOzV|IN88US=> NHLTdJFUSU6JRWK=
CHP-134 M4XwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGiw[mdKSzVyPUK2MlM5PjdizszN NWKyb3pTW0GQR1XS
SW962 NWTufVVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXYUWRKSzVyPUK2MlUxOjFizszN NWnDWpR7W0GQR1XS
SNU-449 NG\vV5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJ5LkC4NFMh|ryP MUXTRW5ITVJ?
HuP-T4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHroXmxKSzVyPUK3MlA5PzlizszN MX;TRW5ITVJ?
SW948 M1zJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnVUWdxUUN3ME2yO{4yOzR2IN88US=> MUfTRW5ITVJ?
NCI-H226 MmDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfVTWM2OD1{Nz60OVc5KM7:TR?= MoC0V2FPT0WU
SK-PN-DW MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjZc3l1UUN3ME2yO{43ODF{IN88US=> NHS0TXpUSU6JRWK=
GI-1 MoDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJ5LkeyNUDPxE1? NYLkcYFYW0GQR1XS
CAL-12T MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[xUWlEPTB;MkiuNVEyOiEQvF2= NVLUfXJWW0GQR1XS
YAPC NWPWRpMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJ6LkK1OlQh|ryP M2XUdXNCVkeHUh?=
SNU-C2B NYrjcHdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ6LkK5OlQh|ryP NXPsSYpSW0GQR1XS
RCC10RGB NXzBV5dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnkTWM2OD1{OD61OFE4KM7:TR?= Mn7wV2FPT0WU
ES7 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3P5ZmlEPTB;MkmuNVQ3PSEQvF2= NXXHRWNDW0GQR1XS
PANC-03-27 M2nvV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnWVJNKSzVyPUK5MlQ1PCEQvF2= MYHTRW5ITVJ?
ES6 NH\EW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJ7LkixOVch|ryP Mn6yV2FPT0WU
HT-1197 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDJN2VKSzVyPUOwMlA2QThizszN MXrTRW5ITVJ?
ZR-75-30 NULiOWVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7ZTWM2OD1|MD6yN|g{KM7:TR?= NUDvdWVvW0GQR1XS
DB NWj5XpIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTNyLkS5OFIh|ryP MXXTRW5ITVJ?
OCI-AML2 NILzO5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTNzLkC2PUDPxE1? MXLTRW5ITVJ?
NCI-H2170 MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjwVJViUUN3ME2zNU45PTF4IN88US=> M{frZ3NCVkeHUh?=
IST-MES1 NF;Je|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGi3c4RKSzVyPUOyMlI5QTdizszN NXqwXG5FW0GQR1XS
769-P NVvFeoNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DYSGlEPTB;M{KuN|Y1OSEQvF2= MYrTRW5ITVJ?
COR-L23 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TWcmlEPTB;M{KuPVA4OyEQvF2= M3fyVHNCVkeHUh?=
SW626 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HHVmlEPTB;M{OuNVc4PiEQvF2= NYTqNnNMW0GQR1XS
LU-139 Mk\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\4bFBmUUN3ME2zN{43PjB3IN88US=> M3jOO3NCVkeHUh?=
HT-144 M3;1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HFbGlEPTB;M{OuPFY{KM7:TR?= NHK0PZVUSU6JRWK=
CaR-1 M4f4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TsT2lEPTB;M{OuPVgzOiEQvF2= M3L1fXNCVkeHUh?=
OE33 MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7yTWM2OD1|ND6yPFU2KM7:TR?= MUjTRW5ITVJ?
COLO-800 Ml3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTN2LkO2OFch|ryP MYTTRW5ITVJ?
NB14 M4TqXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrITWM2OD1|ND60Olg1KM7:TR?= NGDLTFJUSU6JRWK=
KURAMOCHI MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\XZmlEPTB;M{[uNVE6QCEQvF2= Mmm0V2FPT0WU
SW48 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT3TWM2OD1|Nj6yOFc1KM7:TR?= NUHjcFZVW0GQR1XS
Daoy NUizfWFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzNXHBIUUN3ME2zOk43PTN6IN88US=> NWnLNmxqW0GQR1XS
TGBC24TKB MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\TN2dKSzVyPUO2MlY4KM7:TR?= NV\0[484W0GQR1XS
DU-4475 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jSfmlEPTB;M{[uPVA{OyEQvF2= Mn\5V2FPT0WU
SW1417 M4LObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jlSmlEPTB;M{iuNFU2OiEQvF2= NYnDflZHW0GQR1XS
EFO-21 NEXpWmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LrUmlEPTB;M{iuPVM1QSEQvF2= NF7WTJBUSU6JRWK=
MG-63 NEHJc49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX33TpFlUUN3ME2zPU4{PDJ2IN88US=> NFuyN3JUSU6JRWK=
LC-2-ad NHrH[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nnbWlEPTB;M{muOVUyOiEQvF2= MXjTRW5ITVJ?
NOMO-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojnTWM2OD1|OT64Nlc1KM7:TR?= NHKwb3BUSU6JRWK=
COLO-741 M2rFbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXRfmdKSzVyPUSwMlE{ODRizszN MmHEV2FPT0WU
BxPC-3 MkjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzJU2NKSzVyPUSwMlU3QDZizszN M2XQW3NCVkeHUh?=
HSC-2 NFe2SVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLyOZViUUN3ME20NE46OTF|IN88US=> M{W1d3NCVkeHUh?=
UMC-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlGzTWM2OD12MT6yOlMh|ryP Mlz5V2FPT0WU
HCC1937 NEnv[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;EOHhIUUN3ME20Nk44QDR|IN88US=> MYHTRW5ITVJ?
Calu-6 MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjORYNQUUN3ME20N{4zOzh{IN88US=> NUK4WFY6W0GQR1XS
NCI-H1573 Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTR|LkO0O|ch|ryP NIG5eplUSU6JRWK=
SK-N-AS M3\zeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTR|Lk[wNVkh|ryP NVzCWlhxW0GQR1XS
PSN1 NWLtS3ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HZT2lEPTB;NEWuNlU1QCEQvF2= NHjEVVVUSU6JRWK=
TE-11 NYrzNlkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTR3LkS4OFIh|ryP MoD6V2FPT0WU
NCI-H1155 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f1UWlEPTB;NEWuPFk3PyEQvF2= NIDTenVUSU6JRWK=
KM12 NFfGV3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PtdWlEPTB;NEWuPVA4PiEQvF2= NFH1OpdUSU6JRWK=
RO82-W-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorKTWM2OD12Nj65PFIzKM7:TR?= MXjTRW5ITVJ?
SW1573 M{H3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTR5LkO3N|Yh|ryP NUHsSopPW0GQR1XS
CAKI-1 NWDjcVFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zpS2lEPTB;NEiuNlg1PSEQvF2= M4jUWnNCVkeHUh?=
U-118-MG MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\YTWM2OD12OD6zO|AzKM7:TR?= NEDENJJUSU6JRWK=
KYSE-520 M13EPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTR6LkSwNVYh|ryP MVfTRW5ITVJ?
HT55 M2nUdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTR7LkG0O|Qh|ryP NVe4dmdrW0GQR1XS
ChaGo-K-1 NGPTS3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTR7LkS3PVMh|ryP Mn7HV2FPT0WU
IA-LM MnvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;TNlBKSzVyPUW0MlY{OjJizszN M3zCNnNCVkeHUh?=
UACC-62 M2HQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImxPFVKSzVyPUW1MlExPDZizszN NX7JSmYxW0GQR1XS
MKN7 M4i5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTFNGc3UUN3ME21Ok4xOjh3IN88US=> M{n5eXNCVkeHUh?=
HPAF-II MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfwZpQ2UUN3ME21Ok41ODd|IN88US=> MoC4V2FPT0WU
NTERA-S-cl-D1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTxNXNUUUN3ME21O{44PzhizszN MUPTRW5ITVJ?
FTC-133 NITib3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTzc5NTUUN3ME21PE4xQTZ7IN88US=> MlGyV2FPT0WU
MHH-ES-1 NGnBN|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTV6LkS4NVQh|ryP NEj4d2hUSU6JRWK=
JVM-2 M{LLXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTV6Lkm1NFYh|ryP NVHOd5R5W0GQR1XS
TCCSUP NYH6TGJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTV7LkWyO|kh|ryP NXXWTWR6W0GQR1XS
COLO-824 NF\ZUm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnIcJNKUUN3ME22NE4xPzF7IN88US=> M{PZOXNCVkeHUh?=
647-V MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfRSYVUUUN3ME22NE4yOzR5IN88US=> MlqzV2FPT0WU
HD-MY-Z NGO2dFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nOTGlEPTB;NkCuOVI6PCEQvF2= NInJNJZUSU6JRWK=
LS-411N MkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX31e3ViUUN3ME22NU4{QTB|IN88US=> MVHTRW5ITVJ?
NCI-H596 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rnemlEPTB;NkKuO|Q6PiEQvF2= Ml[0V2FPT0WU
C-33-A Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK0TWM2OD14ND6wPVU4KM7:TR?= MXjTRW5ITVJ?
BHY NYjzRYx7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nqW2lEPTB;NkSuNVI1PSEQvF2= M2n0e3NCVkeHUh?=
KGN MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTZ2LkW1NVQh|ryP NXzIXmlxW0GQR1XS
NCI-H1092 NEXR[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT1VHhKSzVyPU[1MlAxQTVizszN NHzyc4pUSU6JRWK=
MZ1-PC M1Pqdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHCTWM2OD14NT61OlQ6KM7:TR?= NGr6UXNUSU6JRWK=
LB831-BLC M{DE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTZ3Lki0PFEh|ryP M3nufXNCVkeHUh?=
SW620 M2SzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[0VWlEPTB;Nk[uNlA{QSEQvF2= NETiNmdUSU6JRWK=
HuO-3N1 M2HGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTZ6LkOyN|gh|ryP MnKyV2FPT0WU
SK-HEP-1 NGexXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTZ7Lkm0PFYh|ryP MkL6V2FPT0WU
LCLC-103H NFXuWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETCW4tKSzVyPUewMlY4ODVizszN MlPsV2FPT0WU
KYSE-70 NHvKVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DXdGlEPTB;N{CuO|g{PSEQvF2= Moj4V2FPT0WU
Mewo NEW3TFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvVTWM2OD15MT61NFUh|ryP M32ybHNCVkeHUh?=
COLO-668 M1LnPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrzOFhwUUN3ME23NU45PDVzIN88US=> MWnTRW5ITVJ?
NCI-H522 NHjQOW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTd{LkO0NVMh|ryP NUDpSG1uW0GQR1XS
NCI-H1437 M2PMfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIToOHZKSzVyPUe0MlQxPDhizszN M{KxfHNCVkeHUh?=
U-266 M1rYbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTPTWM2OD15NT60OVE3KM7:TR?= NIjNTm1USU6JRWK=
MC116 NHi5dpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDkbWxKSzVyPUe1MlU4ODhizszN NFfIV|JUSU6JRWK=
PANC-10-05 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1uzSmlEPTB;N{euOFI1OyEQvF2= MkTaV2FPT0WU
KYSE-180 M2\me2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX3Oo5KSzVyPUe3MlU1PTRizszN MlX0V2FPT0WU
JAR NWjw[5I3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi1XpBKSzVyPUe5MlA2PDZizszN MU\TRW5ITVJ?
CAL-62 NGLTeI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1eyS2lEPTB;OECuNFk2KM7:TR?= M{\B[3NCVkeHUh?=
A3-KAW MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDQOGs3UUN3ME24NE4zOTV2IN88US=> MlT2V2FPT0WU
PANC-08-13 NUDCeFJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRThzLkG3Olgh|ryP M2T0eHNCVkeHUh?=
HSC-3 NVu3[nVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n5fGlEPTB;OEOuN|A4OSEQvF2= NEX4eXNUSU6JRWK=
HTC-C3 MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTh|LkS3NFIh|ryP NVO1U2VoW0GQR1XS
KY821 NF\PUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvITWM2OD16ND6wPFkzKM7:TR?= MnzsV2FPT0WU
DoTc2-4510 NVzi[IR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\NbGRbUUN3ME24OE4zOTh3IN88US=> M1fGeXNCVkeHUh?=
NCI-H1581 NGPSSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTh3LkS2OFEh|ryP MlW5V2FPT0WU
KARPAS-299 MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHOycWxKSzVyPUi2MlE6PzdizszN NXnicI9UW0GQR1XS
IST-MEL1 M4qzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTh4Lki4O|Ih|ryP M2jBdHNCVkeHUh?=
KP-N-YS MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS1TWM2OD16OT65NFI5KM7:TR?= MnGwV2FPT0WU
KYSE-410 M2jXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT1TWM2OD17MT60NFQzKM7:TR?= NXraUINzW0GQR1XS
TE-10 NHu5UGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS2XpNKSzVyPUmxMlU3OTFizszN MWXTRW5ITVJ?
SK-MEL-1 NVvDfIwxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPNWHRDUUN3ME25Nk46OTB4IN88US=> NXHaRXpQW0GQR1XS
COLO-792 M{jSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnwOmVKSzVyPUm1MlI2PjRizszN MWTTRW5ITVJ?
SCH MlK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrRNJJKSzVyPUm2MlM5PzdizszN NX;4TFd3W0GQR1XS
NCI-H1792 NH;uU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XQOWlEPTB;OU[uPFk6OiEQvF2= MUTTRW5ITVJ?
NCI-H2029 MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TpcWlEPTB;OU[uPVU3PiEQvF2= NYPYZll7W0GQR1XS
SW684 MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvhTWM2OD17OD62OlU1KM7:TR?= M3uyNnNCVkeHUh?=
NCI-H209 Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;GTWM2OD1zMECuNVIyKM7:TR?= MnPuV2FPT0WU
HLE Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTFyNT6yPFIh|ryP NGTOe5NUSU6JRWK=
GOTO MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTFyNz63O|ch|ryP MkLsV2FPT0WU
NCI-H1793 Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTFyOT6yPEDPxE1? NFXjb4RUSU6JRWK=
D-392MG MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jpbWlEPTB;MUG3MlM6QCEQvF2= MWTTRW5ITVJ?
SW1990 M1;WfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1e1[mlEPTB;MUKwMlk2OSEQvF2= Mlj6V2FPT0WU
ML-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vqe2lEPTB;MUKxMlY4PiEQvF2= MW\TRW5ITVJ?
NCI-H2452 NF;0SXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTQNnZ1UUN3ME2xNlIvOjFizszN MoriV2FPT0WU
SK-MEL-30 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zlO2lEPTB;MUKzMlI1PCEQvF2= M3f1ZnNCVkeHUh?=
SN12C MnHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImzclRKSzVyPUGyOE4yPzZizszN NFrCRpRUSU6JRWK=
NCI-H1770 NIDFO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjR[45KSzVyPUGyOU42OTRizszN MXLTRW5ITVJ?
SF268 M3z4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;MZpNKSzVyPUGyOk4yPThizszN MWrTRW5ITVJ?
BALL-1 NWG4bZkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnviTWM2OD1zMk[uNlMh|ryP NH3WTXBUSU6JRWK=
COLO-679 M2rKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;Ue2xKSzVyPUGyOk44PTNizszN MXvTRW5ITVJ?
A2780 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml70TWM2OD1zMkiuPVg5KM7:TR?= MWjTRW5ITVJ?
NCI-H1651 M162SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF|MT6yOFMh|ryP MnPkV2FPT0WU
NCI-H2087 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1H4ZWlEPTB;MUOxMlQ5OyEQvF2= M2LiWXNCVkeHUh?=
U-87-MG Mn\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf5TWM2OD1zM{OuOlA1KM7:TR?= NEf0SWJUSU6JRWK=
LB2518-MEL NF:yVWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17FW2lEPTB;MUO1Mlk6OyEQvF2= NYXLcG5YW0GQR1XS
HCT-116 M1uye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq2eJJKSzVyPUGzO{4zOTdizszN M{PJSnNCVkeHUh?=
Ca9-22 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnLV5luUUN3ME2xN|kvQDN|IN88US=> M{fJVHNCVkeHUh?=
COR-L88 NI\pd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4f2TmlEPTB;MUSyMlE1KM7:TR?= NHjD[WdUSU6JRWK=
CP50-MEL-B MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjOVVBKSzVyPUG0OE42ODFizszN M3;6[HNCVkeHUh?=
OVCAR-8 MoruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLuW2FTUUN3ME2xOFUvPjN4IN88US=> MX3TRW5ITVJ?
SK-MEL-3 M17GVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7EXHVXUUN3ME2xOFcvQDd6IN88US=> M3TTbHNCVkeHUh?=
GT3TKB MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDCTWtKSzVyPUG0PU46OjhizszN NXLQWpNjW0GQR1XS
KYSE-450 M{jsXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGWxRWtKSzVyPUG1NU42OzlizszN MkTFV2FPT0WU
CAPAN-1 M3TMUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vo[2lEPTB;MUWzMlA3PCEQvF2= M3XPW3NCVkeHUh?=
BEN M4TFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVraVJFWUUN3ME2xOVMvQTJ6IN88US=> NX[2eJY6W0GQR1XS
NCI-H1304 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nIN2lEPTB;MUW0MlY6PCEQvF2= NELMOYVUSU6JRWK=
KU812 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoSxTWM2OD1zNUiuOlc1KM7:TR?= M3HkNnNCVkeHUh?=
Capan-2 NFrJUplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK1OIJ5UUN3ME2xOlAvPTV|IN88US=> M1rQNnNCVkeHUh?=
A673 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7WXmpZUUN3ME2xOlEvPzB3IN88US=> M2iy[HNCVkeHUh?=
SAS NF3iNY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHjTWM2OD1zNkKuOlc5KM7:TR?= M{n6dHNCVkeHUh?=
NY MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\QSmlEPTB;MU[1MlMyPCEQvF2= M3OzcHNCVkeHUh?=
HCE-4 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF4Nj64OFUh|ryP MUPTRW5ITVJ?
MDA-MB-231 M1:3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPEN5NKSzVyPUG3O{42ODNizszN NF\1NVJUSU6JRWK=
no-10 NWLNdFM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVniPJFTUUN3ME2xO|gvOTN2IN88US=> MWDTRW5ITVJ?
MZ7-mel Mn3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHXTWM2OD1zN{iuOFY4KM7:TR?= M2nWNHNCVkeHUh?=
NCI-H82 NF:1bIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LZVmlEPTB;MUiwMlE3PSEQvF2= M3nMe3NCVkeHUh?=
CAL-72 M1fWXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnLTWM2OD1zOEWuNFU1KM7:TR?= Mo[wV2FPT0WU
NCI-SNU-5 MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTKdJpKSzVyPUG4Ok45PCEQvF2= MmjmV2FPT0WU
OVCAR-4 NHHBemVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XtR2lEPTB;MUi4MlM{OyEQvF2= NXrmSldNW0GQR1XS
SCC-9 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7ITWM2OD1zOUGg{txO NIDhRodUSU6JRWK=
KYSE-150 Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj4O4lKSzVyPUG5NU45QDhizszN NIHubZNUSU6JRWK=
HT-29 NWrxemk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJyMT6yNVIh|ryP NVnxOFlqW0GQR1XS
COLO-678 NIDLdllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33WN2lEPTB;MkCxMlQ2KM7:TR?= NVLFdYxjW0GQR1XS
NCI-H650 M3ruN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:4PWNwUUN3ME2yNFIvOTB|IN88US=> MnHpV2FPT0WU
HuCCT1 Mn;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PYOGlEPTB;MkC0MlIxQCEQvF2= NIPpVnVUSU6JRWK=
SW1116 M{X4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJyNz6wO|ch|ryP NUjE[HdoW0GQR1XS
DBTRG-05MG MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHi[VZKSzVyPUKwO{46ODlizszN NEXIRnhUSU6JRWK=
SW982 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJyNz65OFgh|ryP NET2fGpUSU6JRWK=
RCM-1 M2W2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nu[GlEPTB;MkG0Mlc3OiEQvF2= NGj6[G1USU6JRWK=
COLO-320-HSR NFjUZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvxUoV2UUN3ME2yNVYvOTJ3IN88US=> M4XGW3NCVkeHUh?=
KNS-42 MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr3TWM2OD1{MU[uOVc1KM7:TR?= MmDSV2FPT0WU
C2BBe1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq5d5lKSzVyPUKzNU46ODVizszN MWXTRW5ITVJ?
CCRF-CEM NHHxdm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJ2Mz63PVUh|ryP M2\WN3NCVkeHUh?=
SH-4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjRe2xRUUN3ME2yOFYvODlizszN MYjTRW5ITVJ?
LS-1034 M3TyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPZfW5sUUN3ME2yOFYvOjZ4IN88US=> MXfTRW5ITVJ?
NCI-H2347 NGTkcZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ2Nz63NVMh|ryP MX\TRW5ITVJ?
RPMI-8866 NECy[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJ2OT6yO{DPxE1? MmLqV2FPT0WU
GAK NI\UTYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF72RZdKSzVyPUK1N{4xODJizszN MnXYV2FPT0WU
NB6 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qwbWlEPTB;MkewMlEh|ryP MkPlV2FPT0WU
COLO-680N M3rhd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjLV4VOUUN3ME2yO|IvPTJ5IN88US=> MlHDV2FPT0WU
RERF-LC-MS MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJ5Nj6wNFch|ryP NGXid2tUSU6JRWK=
TGBC11TKB MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3LdFExUUN3ME2yO|gvOTd6IN88US=> NXzRZVNjW0GQR1XS
C8166 NW\NNZQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnQTGtKSzVyPUK3PE42ODZizszN NH\jPYpUSU6JRWK=
HDLM-2 NW\JcmxwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DocGlEPTB;Mkm0MlQxQSEQvF2= NWqwRmtrW0GQR1XS
IGR-1 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DHbGlEPTB;Mkm1MlY2QSEQvF2= Ml\0V2FPT0WU
FADU MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;Y[|dKSzVyPUK5O{42OSEQvF2= MYTTRW5ITVJ?
L-428 NW\jOYtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TMPGlEPTB;Mkm3MlYyPiEQvF2= MYPTRW5ITVJ?
LU-65 MoDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm2S|lKSzVyPUOwOE4{OiEQvF2= NFr5bmlUSU6JRWK=
HEL NY\TRlRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTTTWM2OD1|MEmuPVg{KM7:TR?= MUDTRW5ITVJ?
NCI-H810 M1vJUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr1TWM2OD1|MUCuOVch|ryP MkjTV2FPT0WU
C3A M3LnPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTNzMT64NFIh|ryP NX7rTVRrW0GQR1XS
NCI-H630 NF3pU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTN|Mj6yPVQh|ryP Mme4V2FPT0WU
KP-N-YN MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHk[IRHUUN3ME2zOFEvOTJ|IN88US=> M{fYPHNCVkeHUh?=
MOLT-13 NHH1eFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTN2Mj6zNlYh|ryP MYfTRW5ITVJ?
NCI-H1993 Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PLe2lEPTB;M{SyMlM3PSEQvF2= M3zNNHNCVkeHUh?=
BE-13 M{eyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLNb2I5UUN3ME2zOFQvOTZ5IN88US=> NX74fGFGW0GQR1XS
IST-SL1 M4fucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTN2Nz60NFEh|ryP NEDwVlhUSU6JRWK=
TE-9 NFvlfWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTN4Mz61PFkh|ryP M{HQcHNCVkeHUh?=
LU-135 NYXEcYJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXu1dXpJUUN3ME2zOlcvODN3IN88US=> MXfTRW5ITVJ?
T84 M4e3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnrO3NKSzVyPUO3OE44OTJizszN NHTWZ|lUSU6JRWK=
K-562 Mn7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TSPWlEPTB;M{izMlM3KM7:TR?= NHjVcGtUSU6JRWK=
SBC-5 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjnbVdrUUN3ME2zPFYvQTh3IN88US=> MYjTRW5ITVJ?
NB17 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULLZm4{UUN3ME2zPVIvPTl4IN88US=> M3PBPXNCVkeHUh?=
NCI-H2052 NFfkN|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTN7OD60O|Ih|ryP MVfTRW5ITVJ?
HCC38 NVftVWd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;tbGlEPTB;NECxMlU6OyEQvF2= MV7TRW5ITVJ?
NCI-H69 MnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[4fXNKSzVyPUS0NU4xQDNizszN MnXWV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

カスタマーフィードバック (18)


Click to enlarge
Rating
Source , , Cell, 2015, 160(1-2): 161-76 . MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines Ser78 cells
Concentrations 5 µM
Incubation Time 1 h
Results Two selective AKT inhibitors MK-2206 and GDC-0068, both significantly reduced MKK4 phosphorylation on Ser78 in axons after injury.

Click to enlarge
Rating
Source Cancer Cell, 2013, 24, 766-76. MK-2206 2HCl purchased from Selleck
Method analysis of luciferase activity
Cell Lines immunodeficient NOG mice
Concentrations 10 mg kg-1
Incubation Time 3 days
Results In this experiment, animalstreated with dexamethasone or MK2206 showed progressivetumor growth similar to that observed in vehicle-treated controls,while mice treated with MK2206 plus dexamethasone had significant antitumor responses.

Click to enlarge
Rating
Source Cancer Discov, 2012, 2, 934-47. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines PC9GR4/WZR10 cells
Concentrations 1 uM
Incubation Time 72 h
Results The addition of a dual PI3K and MTOR inhibitor, PI103, or the AKT inhibitor MK-2206, did reduce the expression of pAKT neither in GR4 cells nor WZR10 cells.

Click to enlarge
Rating
Source J Exp Med, 2014, 211(9), 1741-58. MK-2206 2HCl purchased from Selleck
Method 3D migration model
Cell Lines WT or Rap1b-/- neutrophil
Concentrations 2 uM
Incubation Time
Results MK-2206 treatment completely reversed elevated TEM across mouse endothelial cells of Rap1b-/- neutrophils to WT levels (A). It reduced ECM degradation of Rap1b -/- neutrophils, and inhibited their multiple protrusions (B and C). Furthermore, almost all Rap1b -/- cells treated with MK-2206 were found at the endothelial cell junctions (D).

Click to enlarge
Rating
Source Nat Commun, 2015, 6:6943. MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines HUVECs
Concentrations 1 uM
Incubation Time 8 h
Results Because YAP is also a known substrate of Akt21, we examined whether blockade of the Akt pathway affects YAP phosphorylation. Both Ly294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and MK-2206, an allosteric inhibitor of Akt, suppressed cell contact-mediated YAP phosphorylation.

Click to enlarge
Rating
Source Leukemia, 2015, 29(1), 169-76. MK-2206 2HCl purchased from Selleck
Method Immunoblotting
Cell Lines CXCR4S338X-expressing BCWM.1 cells
Concentrations 0.5 uM
Incubation Time 6 h
Results As AKT and ERK, but not BTK, show continued SDF-1a-triggered activation in CXCR4S338X-expressing WM cells treated with ibrutinib, we next sought to clarify if AKT and ERK contributed to the enhanced survival of these cells. It therefore treated SDF-1acultured CXCR4S338X BCWM.1 cells with either AKT- (MK-2206 and AZD-5363) or MEK- (AS-703026, AZD-6244 and UO126) specific inhibitors with and without ibrutinib (0.5 uM) for 6 h so as to clarify the contribution of AKT and ERK to ibrutinib resistance. The inhibitory activity of MK-2206, as well as AS-703026, AZD-6244 and UO126 was confirmed by western blot analysis for pAKT (S473) and pERK (T202/Y204), respectively.

Click to enlarge
Rating
Source Cancer Res, 2013, 73, 2189-98. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines SKNAS/SJNB8/IMR32/GIMEN/SHEP2/KCNR/NGP/LAN1/LAN5/TR14/UHGNP cell lines
Concentrations 8 μM
Incubation Time 48 h
Results The 8 μM MK-2206 treatments resulted in effective pathway inhibition in all cell lines as shown by western blot for phosphoryl ated FOXO3a and PRAS40 as well as AKT serine 473 phosphorylation.

Click to enlarge
Rating
Source Oncotarget, 2011, 2, 1109-26. MK-2206 2HCl purchased from Selleck
Method Western blot/ Wst-1 assay
Cell Lines ATC/ FTC cell lines
Concentrations 500 nM
Incubation Time 1 h/72 h
Results One-hour treatment with the AKT inhibitor MK-2206 (0.5 μM) or with the MEK inhibitor U0126 (10 μM) effectively abolished AKT and ERK1/2 phosphorylation in all cell lines.

Click to enlarge
Rating
Source Sci Signal, 2011, 4, rs9. MK-2206 2HCl purchased from Selleck
Method ELISA
Cell Lines HeLa cells
Concentrations 1 μM
Incubation Time
Results Treatment of infected cells with kinase inhibitors directed at Akt (MK-2206), MEK(PD 98059), PKC(CEC), or Pim family kinases identified a dominant role for Pim family kinases in the release of IL-8 from Salmonella-infected epithelial cells.

Click to enlarge
Rating
Source FASEB J, 2013, 27, 1644-56. MK-2206 2HCl purchased from Selleck
Method Clonogenic growth assay
Cell Lines U2OS cells
Concentrations 1 μM
Incubation Time 9 d
Results Specific inhibition of PKB activity using MK-2206 or triciribine also significantly reduced cell growth, although to a lesser extent compared to PI-103, suggesting that both the PKB and mTOR pathways are important for anchorage-dependent growth.

Click to enlarge
Rating
Source Gynecol Oncol, 2011, 123, 13-8. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines ovarian cancer cell lines
Concentrations 1-6 μM
Incubation Time 1 h/72 h
Results Activation of pAKT by IGF-1 in the low-grade cell line HOC-7 was blocked by the AKT inhibitor MK-2206.

Click to enlarge
Rating
Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Confocal microscopy
Cell Lines platelets
Concentrations 1μM
Incubation Time
Results Upon treatment with increasing concentrations of AEA from 0.1 to 10 mM (Fig. B–D) platelets were fully fluorescently marked as compared to control (Fig. A) and the increase in DAF 2 fluorescence intensity appears to be dose-dependent. In agreement with data shown in Figure 4, SR1(Fig. E) and MK2206 (Fig. F) abolished fluorescence intensity induced by AEA, while LY294002 (Fig. 5G) was less potent.

Click to enlarge
Rating
Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines platelets
Concentrations 1 μM
Incubation Time
Results eNOSser1177 phosphorylation was greatly reduced by LY294002 and cancelled by MK2206 but it was not modified by platelet pretreatment with EGTA or BAPTA/AM.

Click to enlarge
Rating
Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Nitriter+Nitrate(NOX) measurement, cGMP detection
Cell Lines platelets
Concentrations 1 μM
Incubation Time 1 min
Results As shown in Figure 4 SR1 significantly reduced both NOx and cGMP formation, while SR2 failed to affect these parameters.

Click to enlarge
Rating
Source Radiat Oncol, 2009, 4, 43. MK-2206 2HCl purchased from Selleck
Method Western blot, clonogenic survival assay
Cell Lines U87MG cells
Concentrations 1 μM
Incubation Time 1 h
Results Akt inhibitor MK-2206 showed similar effect. MK-2206 is a potent allosteric Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3 respectively. U87MG cells were preincubated with 1 μM MK-2206 for 1 hr, followed by irradiation at 0 - 9 Gy. As shown in Fig C, MK-2206 treatment abolished IR-induced Akt phosphorylation. Moreover, treatment with MK-2206 also increased the radiosensitivity of U87MGcells (Fig. D)

Click to enlarge
Rating
Source Dr. Zhang of Tianjin Medical University. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines Breast cancer cells
Concentrations 0-10 nM
Incubation Time 3 h
Results Breast cancer cells were serum starved for 24 h, pretreated with the indicated concentrations of MK-2206 for 3 h, and then treated with 100ng/ml EGF for 15 min.

Click to enlarge
Rating
Source Biochim Biophys Acta, 2012, 1823, 987-96. MK-2206 2HCl purchased from Selleck
Method Immunofluorescence
Cell Lines HC11 cells
Concentrations 10 µM
Incubation Time 1 h
Results whole ADRP levels, estimated by Western blot , decreased only in the presence of MK -2206 and LY294002. In most cases, ADRP decorated the surface of small lipid droplets and appeared as little patches on large cytoplasmic lipid droplets. With the exception of SP600125, which induced a strong ADRP coating of almost all cytoplasmic lipid droplets (although this inhibitor did not increase ADRP synthesis), variation in the distribution of ADRP at the surface of lipid droplet was difficult to estimate, notably because the signal was faint and uneven.

Click to enlarge
Rating
Source MK-2206 2HCl purchased from Selleck
Method Western blot analysis
Cell Lines MCF-7 cells
Concentrations 0 nM/100 nM/250 nM/1000 nM
Incubation Time 24 h
Results The effect of MK-2206 on the serine 473 phosphorylation mark of AKT 1 was uneven and did not correlate with inhibition of AKT activity, but the AKT1 mutant cells maintained higher levels of AKT1 serine 473 phosphorylation with increasing concentrations of MK-2206. Of note, MK-2206 completely inhibited AKT2 activation at 100 nM, a concentration where PIK3CA E545K mutant, but not AKT1 mutant cells were already strongly growth inhibited. MK-2206 treatment up to 1 μM did not have strong effects on other protein biomarkers such as ribosomal protein S6, ev en though growth was suppressed by approximately 80% in MCF-7 cells at this concentration.

文献中の引用 (170)

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related Akt 阻害剤

  • Afuresertib (GSK2110183)

    Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

  • AT13148

    AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.

  • SC79

    SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.

  • TIC10

    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.

  • AZD5363

    AZD5363は、有力なAkt阻害剤で、Akt1、Akt2とAkt3に作用すると、 IC50がそれぞれ 3 nM、 8 nM 、 8 nMです。

    Features:Moderate preclinical tolerability, and PD characteristics of an AKT inhibitor. Distinct profile from other AKT inhibitors in clinical development.

  • Ipatasertib (GDC-0068)

    Ipatasertib (GDC-0068)は、5nM、18nMと8nMのIC50でAkt1、Akt2とAkt3を目標としている非常に選択的な汎Akt阻害剤です。

  • GSK690693

    GSK690693は、Akt1、Akt2とAkt3を目標としている汎Akt阻害剤で、IC50 がそれぞれ 2 nM、13 nM、9 nMです。

  • Perifosine (KRX-0401)

    Perifosine (KRX-0401)は、4.7 nMのIC50による新しいAkt阻害剤です。

  • A-674563

    A-674563は、Akt1 抑制影響を示しまして、Ki が 11 nMです。

    Features:Orally bioavailable compound (achieved by replacing indole of A-443654 with phenyl moiety) and somewhat less selective for Akt over PKA than A-443654.

最近チェックしたアイテム

Tags: MK-2206 2HClを買う | MK-2206 2HCl供給者 | MK-2206 2HClを購入する | MK-2206 2HCl費用 | MK-2206 2HCl生産者 | オーダーMK-2206 2HCl | MK-2206 2HCl代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ