MK-2206 2HCl 化学構造
分子量: 480.39

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Quality Control & MSDS

製品説明

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    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HClは高度選択的に Akt1, Akt2 and Akt3を抑制して、 IC50がそれぞれ 8 nM, 12 nM と 65 nMになる。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 M{G3PGN6fG:2b4jpZ{BCe3OjeR?= MUOzJO69VQ>? NUjndZJqPzJiaB?= Mo[0SG1UVw>? M1nmS2lvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:w NXHz[phxOjB3N{GwOlk>
A431 MXrLbY5ie2ViQYPzZZk> NU\UeolSPSEQvF2= M1;4RlUhcA>? MWTEUXNQ M2TMWnN2eHC{ZYPz[ZMhfGinIIPp[45idGmwZzDv[kBCc3RiYX7kJGVzcw>? NFLRT4YzODV5MUC2PS=>
HepG2 MlvTR5l1d3SxeHnjJGF{e2G7 M4f2XlExKM7:TR?= MmLVNlQhcA>? NFrPdJJFVVOR NGmxZW1U\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> NV60S|I5OjF{MEW5NlU>
Sk-Hep1 NIr1SYREgXSxdH;4bYMhSXO|YYm= MoHwNVAh|ryP NWT4[mlPOjRiaB?= MmX3SG1UVw>? NWTWS3ltW2Wwc3n0bZpmeyC{ZYPpd5RidnRiY3XscJMhfG9idHjlJIN6fG:2b4jpZ{Bm\m[nY4Sgc4Yhe2:{YX\lcolj NHHp[lkzOTJyNUmyOS=>
OCUT1 cells harbored PIK3CA (H1047R+/+) Mm\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy0[GRpOyEQvF2= M3jXfVUh\A>? NIXxbmJFVVOR M{e5VmlEPTB;MD6xOEDPxE1? MoHUNlEzQDl{Nke=
K1 cells harbored PIK3CA (E542K+/+) M1W1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVqzJO69VQ>? NXKzPXFxPSCm NVq4SoNjTE2VTx?= MYDJR|UxRTBwNUKg{txO NVznTpd1OjF{OEmyOlc>
FTC133 cells harbored PTEN (allele deletion and R130+) Mnf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF35U2U{KM7:TR?= M1nJclUh\A>? MWfEUXNQ NV7QS5FPUUN3ME2wMlE5KM7:TR?= NYDMNHIzOjF{OEmyOlc>
C643 cells harbored HRAS (G13R+/−) NU\mZplDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVKzVVJ3OyEQvF2= MWS1JIQ> MVPEUXNQ M4DrWWlEPTB;MD6yO{DPxE1? NXvYNYplOjF{OEmyOlc>
Hth7 cells harbored NRAS (Q61R+/−) NE\sPVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XGfVMh|ryP MYm1JIQ> MlXlSG1UVw>? MonFTWM2OD12LkWg{txO M4jw[|IyOjh7Mk[3
TPC1 cells harbored RET/PTC1 rearrangement NUPnOXd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnGN{DPxE1? M1r1TFUh\A>? MlT5SG1UVw>? MXvJR|UxRTBwNUmg{txO NXK2bFl2OjF{OEmyOlc>
Hth74 NID1RZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHqN{DPxE1? MoL0OUBl MYXEUXNQ M33zRmlEPTB;Mj6xPUDPxE1? MoDtNlEzQDl{Nke=
KAT18 MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HtN|Mh|ryP NF;OUII2KGR? NYPpeohwTE2VTx?= M2DiVWlEPTB;ND62NkDPxE1? NVrIOFRWOjF{OEmyOlc>
SW1736 NXHtfIRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX[xNFAh|ryP NY[2VY5XPSCm NWfYb4FsTE2VTx?= M{e2RmlEPTB;NEeuOVYh|ryP M1uyNVIyOjh7Mk[3
WRO Ml7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[4bIQyODByIN88US=> MnH0OUBl M1PnOWROW09? MWHJR|UxRjFyMECg{txO M1PPN|IyOjh7Mk[3
TAD2 NV3MPXBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWezT4tZOTByMDFOwG0> MXS1JIQ> NV3Wd2hITE2VTx?= NFrHdVBKSzVyPkGwNFAh|ryP MVOyNVI5QTJ4Nx?=
LN229 NXPHelE4SXCxcITvd4l{KEG|c3H5 NH\CdHQxNjVizszN MXq2NEBp NGPaVHhFVVOR MlnlRZVodWWwdIOgZZBweHSxZ3XubYMh\W[oZXP0d{Bw\iCpZX\peIlvcWJ? M4nzNFIzODV5OUG0
T98G NUT1VIhRSXCxcITvd4l{KEG|c3H5 M4T6TVAvPSEQvF2= NYPwVIRYPjBiaB?= MYXEUXNQ NV\zU|VKSXWpbXXueJMh[XCxcITv[4VvcWNiZX\m[YN1eyCxZjDn[YZqfGmwaXK= MkjINlIxPTd7MUS=
HC11 NH;BcHBHfW6ldHnvckBCe3OjeR?= MXWxNEDPxE1? MmLSNlQhcA>? MXnEUXNQ NXfEWZJRUW6qaXLpeJMh|rJvY3Hz[YlvKGGwZDDBSHJRKHO7boTo[ZNqew>? NFPyZo0zOjR{Nk[yNS=>
MOLT-4 MXfDfZRwfG:6aXOgRZN{[Xl? MVyxNEDPxE1? M2r0ZVQ5KGh? MWnEUXNQ NEfPfFRKSzVyPUGuO-KBkc7:TR?= NWXxfVF2OjJ4MUSyOFM>
CEM-R M2DMdWN6fG:2b4jpZ{BCe3OjeR?= MUKxNEDPxE1? MkHZOFghcA>? MmnPSG1UVw>? NG\PSZdKSzVyPUOuN-KBkc7:TR?= MWiyNlYyPDJ2Mx?=
CEM-S NEW5fGFEgXSxdH;4bYMhSXO|YYm= M{Ppb|ExKM7:TR?= M1z0OlQ5KGh? M3nuNWROW09? NIW5NG5KSzVyPUWuNgKBkc7:TR?= NYrGdFllOjJ4MUSyOFM>
MOLT-4 M1fuO2Z2dmO2aX;uJGF{e2G7 MnWyNVAh|ryP MmL5NlQhcA>? NXzURog5TE2VTx?= NYq5R3VlSmyxY3vzJINmdGy|IHnuJJRp\SCJMD;HNUBxcGG|ZTDv[kB1cGViY3XscEBkgWOuZR?= MmnFNlI3OTR{NEO=
MOLT-4 M3yxTmZ2dmO2aX;uJGF{e2G7 MkLuOQKBkc7:TR?= NYDMfVV1PCCq M4P6WWROW09? NXjoVlRNUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|NCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ MmDENlI3OTR{NEO=
CEM-R M4jpNWZ2dmO2aX;uJGF{e2G7 NEjiVZk16oDLzszN NGfBTHI1KGh? M13z[mROW09? NEO0[otKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDOGEwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? NVXGXWozOjJ4MUSyOFM>
CEM-S NGC4OHVHfW6ldHnvckBCe3OjeR?= MV:05qCK|ryP MYe0JIg> NIH0THlFVVOR M2rV[Wlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFO1RU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? M{LYe|IzPjF2MkSz
HepG2 cell MVrLbY5ie2ViQYPzZZk> M{TiNFIxKM7:TR?= NUO1fGpROjRiaB?= NFP0e3BFVVOR NVvYTG11TG:5boLl[5Vt[XSnczD0bIUheGixc4Doc5J6dGG2aX;uJI9nKEGNVB?= MkXnNlM4QTd|MUm=
HepG2 cell MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF65VWg{OCEQvF2= NWf3eHRiOjRiaB?= M4LMeWROW09? MV\Jcohq[mm2czDj[YxtKGe{b4f0bC=> M1XaOFI{Pzl5M{G5
HepG2 cell MUHBdI9xfG:|aYOgRZN{[Xl? NWLGSJZnOjBizszN Mn6yNlQhcA>? M4HtVmROW09? M2iz[Glv\HWlZYOgZ4VtdCCjcH;weI9{cXN? M1;tV|I{Pzl5M{G5
GEO NUK4TnkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\jOVAxKG6P M{PtOFczKGh? NFfzOJdFVVOR MWPJcohq[mm2czDj[YxtKGe{b4f0bC=> MWmyOFU5OTJ|MR?=
CNE-1 NXrvWo11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUSxNEDPxE1? NGH4UYw6PiCq NUPCPVVJTE2VTx?= M17UO2lEPTB;Mj65OkDPxE1? Mnm4NlU{OzZ7MkW=
CNE-2 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjpN4wyOCEQvF2= NELXeYg6PiCq NUL2cINqTE2VTx?= MmPhTWM2OD12LkWzJO69VQ>? MkG5NlU{OzZ7MkW=
HONE-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;kNVAh|ryP NFOwVlM6PiCq MYrEUXNQ NVq5OVJrUUN3ME2zMlM4KM7:TR?= M4rj[|I2OzN4OUK1
SUNE-1 NWWxNItbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnPR4YyOCEQvF2= NVH5TGlRQTZiaB?= MX3EUXNQ NYnD[2t5UUN3ME2wMlUzKM7:TR?= M3TW[lI2OzN4OUK1
CNE-2 MmTNSpVv[3Srb36gRZN{[Xl? MmHFNVAh|ryP NHjOTpM1QCCq M1fvUGROW09? M1;uSWlv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhTzF? M{jDeVI2OzN4OUK1
HONE-1 NFnCbVRHfW6ldHnvckBCe3OjeR?= NILMSIoyOCEQvF2= M4HIelQ5KGh? MVvEUXNQ NUTHR5U2UW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCJMR?= M130XlI2OzN4OUK1
NEC8 NHj5dWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjj[GFKSzVyPUCuNFk3PTFizszN MnnLV2FPT0WU
P12-ICHIKAWA MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnPTWM2OD1yLkGxOlIh|ryP NYTJcmczW0GQR1XS
MDA-MB-175-VII NVXIVVVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMUO3N|gh|ryP M3nxNXNCVkeHUh?=
AsPC-1 M3SwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL3SnJXUUN3ME2wMlIzOTJ{IN88US=> NXTTeXhGW0GQR1XS
T47D NXvtOHpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMkiyOUDPxE1? MkT6V2FPT0WU
HH NULnR2c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTtdJR1UUN3ME2wMlMxOjh|IN88US=> NVHWWHJxW0GQR1XS
MOLT-16 MmOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4WwfWlEPTB;MD6zNFMzKM7:TR?= MYLTRW5ITVJ?
ES5 Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP1cHVKSzVyPUCuN|Q1PTVizszN MXLTRW5ITVJ?
RS4-11 NWHFN3JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vseGlEPTB;MD6zOFYyKM7:TR?= MXLTRW5ITVJ?
KARPAS-45 MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG2OoJKSzVyPUCuN|c{OjFizszN MlHKV2FPT0WU
NCI-H720 MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwM{e2O|kh|ryP M1jHcHNCVkeHUh?=
H9 NGixcmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LOVGlEPTB;MD6zPFg5OyEQvF2= NV;HfXRUW0GQR1XS
EFM-19 M{fD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TjfmlEPTB;MD60OFAyKM7:TR?= MVrTRW5ITVJ?
SBC-1 Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\pTWM2OD1yLkS0NFM2KM7:TR?= NHjndm5USU6JRWK=
A4-Fuk M4ewV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfxTmdKSzVyPUCuOFY5PjhizszN NGTkNJZUSU6JRWK=
NCI-H1563 MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmniTWM2OD1yLkS4NVg6KM7:TR?= NX[0PGtnW0GQR1XS
HCC1419 Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX60NW9qUUN3ME2wMlQ5QDl{IN88US=> MnzSV2FPT0WU
H-EMC-SS NYXJ[ZQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e4NmlEPTB;MD60PVk{QSEQvF2= NEj6fnVUSU6JRWK=
BHT-101 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwNUK5OlEh|ryP M2DKNHNCVkeHUh?=
IGROV-1 Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLMTWM2OD1yLkW1NlQ6KM7:TR?= MWnTRW5ITVJ?
HGC-27 M13OcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwNU[3PFMh|ryP M1TuXXNCVkeHUh?=
MDA-MB-361 M2frRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4qydmlEPTB;MD61O|c3OSEQvF2= MYXTRW5ITVJ?
KE-37 NVSwOZdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLLd5I2UUN3ME2wMlU5OjZizszN NFX6b2tUSU6JRWK=
HCC70 MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwNUm4Nlch|ryP NXjjeIx{W0GQR1XS
LNCaP-Clone-FGC MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwNkGwOFgh|ryP NF7G[WJUSU6JRWK=
HAL-01 NXrDRoYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwNkKxN{DPxE1? MV7TRW5ITVJ?
HT MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfoTWM2OD1yLk[zNlM6KM7:TR?= MljLV2FPT0WU
MDA-MB-415 NIq2Z5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HU[mlEPTB;MD62N|YzPiEQvF2= M3KzPHNCVkeHUh?=
NOS-1 NGXY[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHXTWM2OD1yLk[zO|I{KM7:TR?= NXLnSlJsW0GQR1XS
DU-145 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorvTWM2OD1yLk[0O|Q2KM7:TR?= MXTTRW5ITVJ?
OCUB-M Mnr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEO0T|BKSzVyPUCuO|A6PjZizszN MYXTRW5ITVJ?
VA-ES-BJ NUjuN2NMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPBTWM2OD1yLkezNFI2KM7:TR?= NXjlZmUxW0GQR1XS
J-RT3-T3-5 MlexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjzfZNKSzVyPUCuO|Q1ODNizszN MkTEV2FPT0WU
MOLT-4 NXTyZ|VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi4eGhKSzVyPUCuPFA2QDJizszN MmHIV2FPT0WU
NB7 Mn3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz1WVZKSzVyPUCuPFI1OTFizszN M4DVOnNCVkeHUh?=
L-363 MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLhUG1jUUN3ME2wMlg{PDR{IN88US=> Mn2zV2FPT0WU
NKM-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LzVWlEPTB;MD64OlI2OyEQvF2= NGS1fHpUSU6JRWK=
HOP-92 NEjSZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXPdJJKSzVyPUCuPFczOjNizszN MoLqV2FPT0WU
OAW-42 MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwOEi3NkDPxE1? MWXTRW5ITVJ?
HuO9 MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULSZms{UUN3ME2wMlkzPzVzIN88US=> MX\TRW5ITVJ?
MFE-280 MoPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwOU[0OlUh|ryP MmnxV2FPT0WU
EM-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrWTWM2OD1yLkm3PVM6KM7:TR?= NICyVWtUSU6JRWK=
NCI-H520 Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33R[WlEPTB;MD65PFU6OiEQvF2= MlTpV2FPT0WU
LB2241-RCC NUflOHZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3v3UWlEPTB;MD65PVc{PCEQvF2= M1zqWHNCVkeHUh?=
SK-NEP-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4D5[2lEPTB;MT6xOFQ5PSEQvF2= NWLWc2FrW0GQR1XS
LXF-289 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFi5SHlKSzVyPUGuNVcyPTZizszN M2HRbHNCVkeHUh?=
EPLC-272H NFTRRZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFwMUeyOVYh|ryP M37zb3NCVkeHUh?=
COLO-684 NIjaRpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrjN4NKSzVyPUGuNlM4OjVizszN NHHhUplUSU6JRWK=
ES1 M17HdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH71Wm5KSzVyPUGuNlQxPjVizszN M4DqS3NCVkeHUh?=
DOHH-2 M4DnUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnwVmozUUN3ME2xMlI5OjB|IN88US=> M3zqeHNCVkeHUh?=
CTB-1 NUDpblI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HPPGlEPTB;MT6yPFk6KM7:TR?= NWCydWJuW0GQR1XS
G-401 NXPn[25XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfTTWM2OD1zLkK5O|k2KM7:TR?= MWrTRW5ITVJ?
LoVo NWjOXHNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfne5pKSzVyPUGuN|I2OzRizszN MUjTRW5ITVJ?
Ramos-2G6-4C10 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILYZ2lKSzVyPUGuN|M4ODFizszN M4DJU3NCVkeHUh?=
MFM-223 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDoTWM2OD1zLkO0OFYyKM7:TR?= MV3TRW5ITVJ?
PA-1 MonYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTQRndKSzVyPUGuN|UzPjVizszN MYHTRW5ITVJ?
697 Mke0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTZSpYyUUN3ME2xMlM4PjF4IN88US=> NIXkblZUSU6JRWK=
QIMR-WIL MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnlepRKSzVyPUGuOFkyOTZizszN NXW5OHZnW0GQR1XS
HOS MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3vblZKSzVyPUGuOFk2PThizszN NUDrdHE5W0GQR1XS
DMS-273 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\Gb4tKSzVyPUGuOVE6PTlizszN M2rHVHNCVkeHUh?=
ME-180 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL5TWM2OD1zLkW2PFkyKM7:TR?= MVPTRW5ITVJ?
HCC2218 NFLYT3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrKeXVKSzVyPUGuOlgzOjVizszN M1S0eXNCVkeHUh?=
CAL-54 MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnGdlVKSzVyPUGuO|EzPDJizszN MX3TRW5ITVJ?
OMC-1 MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq4XmVKSzVyPUGuO|Q3PzdizszN M2r2N3NCVkeHUh?=
COR-L105 NEHsPYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\QTWM2OD1zLke5O|M4KM7:TR?= MVvTRW5ITVJ?
BV-173 NVHCUXFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\vU5NKSzVyPUGuPFExPzRizszN MWjTRW5ITVJ?
RKO Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFwOEexNFEh|ryP NULtXG9bW0GQR1XS
SNU-387 NGPNeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHTTWM2OD1zLki4OFA3KM7:TR?= NFnuZWdUSU6JRWK=
SW1088 NGjTRpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFwOUS2NFYh|ryP MnzOV2FPT0WU
Hs-578-T M{K2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n2[2lEPTB;Mj6xNVQ{OyEQvF2= NWfPNW5YW0GQR1XS
OC-314 M2nKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDlRmtKSzVyPUKuNVUxQDZizszN NHjvbWlUSU6JRWK=
RMG-I M4\lO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHmXYRsUUN3ME2yMlE3Ozl6IN88US=> NVzpTmgxW0GQR1XS
NCI-H1395 NWjNToNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX4d2JKSzVyPUKuNVgxQTFizszN M1S4bXNCVkeHUh?=
GAMG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHyNmFoUUN3ME2yMlI{QDR3IN88US=> MUDTRW5ITVJ?
LB1047-RCC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXZTWM2OD1{LkK0N|E4KM7:TR?= MofFV2FPT0WU
MN-60 MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTJwMkm5NlMh|ryP MorUV2FPT0WU
OAW-28 NIn2cFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnMcXIyUUN3ME2yMlI6QTVzIN88US=> NUCwb5ZXW0GQR1XS
NCI-H2228 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJwM{G1OVIh|ryP M{joWHNCVkeHUh?=
ABC-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3pOohwUUN3ME2yMlM{OjV|IN88US=> NIDL[GJUSU6JRWK=
LS-513 NH7ZeJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn2TWM2OD1{LkOzOFg1KM7:TR?= MnTwV2FPT0WU
KS-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDmcHVKSzVyPUKuN|gyQTFizszN NEnKToxUSU6JRWK=
NB69 NVKy[W11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJwM{i5PFMh|ryP M1vKSnNCVkeHUh?=
VM-CUB-1 NWKzbJg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HQW2lEPTB;Mj6zPVA5OyEQvF2= NUnHVlZPW0GQR1XS
D-423MG NVHSOFh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJwNEGwOFQh|ryP NFzWUnZUSU6JRWK=
EW-18 M2ixdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrFVGUyUUN3ME2yMlQyQTN7IN88US=> NUjCNYZuW0GQR1XS
YH-13 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nEWmlEPTB;Mj60OlE2OyEQvF2= NGfUOpNUSU6JRWK=
T-24 NIDKZ3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[2TWM2OD1{LkS3PFgyKM7:TR?= MYHTRW5ITVJ?
ES8 MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJwNEmyPFch|ryP MnO3V2FPT0WU
ES3 NH\ON3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJwNEm3OVkh|ryP MYjTRW5ITVJ?
RXF393 NXvHe21iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHpTWM2OD1{Lk[wOFg4KM7:TR?= NXv1[m1tW0GQR1XS
RPMI-8226 M1XreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnqUFNMUUN3ME2yMlYzQTV|IN88US=> MYPTRW5ITVJ?
AGS MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LycGlEPTB;Mj63NlE{PyEQvF2= NELPbHNUSU6JRWK=
HCC1395 M2jaVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETGb5hKSzVyPUKuO|UyQDdizszN MVHTRW5ITVJ?
MV-4-11 NIDWbFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWze293UUN3ME2yMlc2OjZ4IN88US=> NUPKfmFqW0GQR1XS
A204 NW[xZY96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3VVXZKSzVyPUKuPFM5PzJizszN M13BZXNCVkeHUh?=
MCF7 M3nwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\zeWlEPTB;Mj64OlEyPyEQvF2= M{LrSnNCVkeHUh?=
SNU-423 NV3oNIxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJwOEmyOFIh|ryP M3zvenNCVkeHUh?=
NCI-H1048 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\pTWM2OD1{Lkm2PFY2KM7:TR?= M3zscXNCVkeHUh?=
GR-ST M4r2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfnS3pKSzVyPUOuNFQ3OTFizszN M1npS3NCVkeHUh?=
EoL-1- MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfFcHZKSzVyPUOuNFcxPThizszN MnnRV2FPT0WU
HuH-7 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTvTWM2OD1|LkC5OFY1KM7:TR?= MkfaV2FPT0WU
OS-RC-2 MoPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTNwMUGxPUDPxE1? NFrjOWJUSU6JRWK=
EW-3 MmqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfyTWM2OD1|LkG5OVI6KM7:TR?= MorvV2FPT0WU
NCI-H747 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTNwMkC2PVQh|ryP NE\JNpVUSU6JRWK=
EW-16 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr2fJRkUUN3ME2zMlIyQDd7IN88US=> MkD5V2FPT0WU
DOK M3nkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEG3WXdKSzVyPUOuNlI5PTlizszN NUXVR5VkW0GQR1XS
HCC2157 NF71S4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTNwM{ixO|kh|ryP MlfhV2FPT0WU
OVCAR-3 NFnXZnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTNwNEC3PFYh|ryP NVezSoJoW0GQR1XS
NCI-H1623 M4qxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXaNWF1UUN3ME2zMlQyOjJ2IN88US=> NIj0fZhUSU6JRWK=
H4 MnjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTNwNEW2NlYh|ryP MU\TRW5ITVJ?
SW1710 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K4[2lEPTB;Mz60OlY4QCEQvF2= Ml[0V2FPT0WU
RT-112 NVS2Z3dVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjsTWM2OD1|LkWyN|g5KM7:TR?= MknrV2FPT0WU
DMS-114 Ml;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLIRYw3UUN3ME2zMlYzOjd6IN88US=> M2D4ZXNCVkeHUh?=
AN3-CA NInWXGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4mxeWlEPTB;Mz62NlQ2PiEQvF2= MmKxV2FPT0WU
KNS-62 M1vIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInt[3hKSzVyPUOuOlM{OzhizszN MXnTRW5ITVJ?
SJRH30 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jhOGlEPTB;Mz62PVEzOiEQvF2= MWPTRW5ITVJ?
G-402 NXvXVWZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7pTWM2OD1|LkewO|EyKM7:TR?= MnrYV2FPT0WU
MHH-PREB-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\KSG5PUUN3ME2zMlczODN6IN88US=> M4Lq[3NCVkeHUh?=
P30-OHK NIXIV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTNwOEC5O|Yh|ryP MnfvV2FPT0WU
RVH-421 NWH3SnRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXRTWM2OD1|LkixO|g5KM7:TR?= NITxZZhUSU6JRWK=
LU-134-A MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfkN2hKSzVyPUOuPFg1OjhizszN MlLOV2FPT0WU
ECC10 NF25T5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT1TWM2OD1|LkmzOlIzKM7:TR?= Mke5V2FPT0WU
TGW M2TtXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDxcXFVUUN3ME20MlAzOzB3IN88US=> MUnTRW5ITVJ?
MLMA M1nZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTRwMEK5OlYh|ryP NWDMRY45W0GQR1XS
SCC-25 NVHFRYVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof0TWM2OD12LkC2OVY3KM7:TR?= MXnTRW5ITVJ?
TYK-nu MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[xbVRpUUN3ME20MlA6PTN2IN88US=> M3z4Z3NCVkeHUh?=
LAMA-84 NITtcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPGfXg5UUN3ME20MlE1OTlzIN88US=> MUHTRW5ITVJ?
Calu-3 NIrlXHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTRwMkS0NVYh|ryP MoTNV2FPT0WU
NCI-H460 NHzLTolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTCeXlKSzVyPUSuNlY1PDNizszN MX;TRW5ITVJ?
EGI-1 MorzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\abYVKSzVyPUSuN|c4PzhizszN Mn7YV2FPT0WU
NCI-H292 NEm3UXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGflVWVKSzVyPUSuN|gyPDZizszN M4Xk[XNCVkeHUh?=
HCE-T MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvwbIpKSzVyPUSuOFE2PzlizszN Ml;5V2FPT0WU
EW-11 NW[0SIZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XiSmlEPTB;ND60NVg{QCEQvF2= NWjvXFVHW0GQR1XS
ATN-1 NEHFTJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTRwNESzNFQh|ryP NXW1ZnpwW0GQR1XS
NB5 Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTRwNUO2PVch|ryP M{\Oc3NCVkeHUh?=
KLE NWLnUmVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\0WmlEPTB;ND63NFE6QCEQvF2= MnLnV2FPT0WU
CAL-39 M{XweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;HTmFKSzVyPUSuO|IyPDZizszN M3rEc3NCVkeHUh?=
TI-73 M1K5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHriNVRKSzVyPUSuPFA3ODlizszN MWnTRW5ITVJ?
HO-1-N-1 NH6wfoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\ETWM2OD12Lkm0NkDPxE1? NV7OXYxGW0GQR1XS
786-0 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTRwOUS2O|Mh|ryP Mn34V2FPT0WU
SK-N-DZ M13Remdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\sTWM2OD12Lkm2NVQzKM7:TR?= M1HZXHNCVkeHUh?=
NCI-H446 MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTVwMkCwNFkh|ryP NXTyOndqW0GQR1XS
ETK-1 NWXuNGpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LCZmlEPTB;NT6yNVE3PSEQvF2= NEDvWZBUSU6JRWK=
BT-20 M3LBcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vreGlEPTB;NT6yNVM2OyEQvF2= MkXWV2FPT0WU
MEL-HO NHS2O41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3uNI9KSzVyPUWuN|c{OzZizszN MW\TRW5ITVJ?
CAL-27 M2HscWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHJTWM2OD13LkS2N|M6KM7:TR?= MnzsV2FPT0WU
SW872 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULWeoVKUUN3ME21MlU6PDJ6IN88US=> NWCwPIttW0GQR1XS
RPMI-2650 NYTIbYZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXzeIlKSzVyPUWuOlYyQTlizszN NEDROJJUSU6JRWK=
PFSK-1 NUn0SWtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7a[FZKSzVyPUWuO|I4OzJizszN MX\TRW5ITVJ?
SF295 M4riXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7Wc4NnUUN3ME21MlgxPjN|IN88US=> NWO1NZUxW0GQR1XS
Becker MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTVwOE[0O|Ih|ryP NGL1WJNUSU6JRWK=
Saos-2 M2Lpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTVwOE[1N{DPxE1? NV[1OVl3W0GQR1XS
SK-OV-3 M1TOUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DYSmlEPTB;NT65PVgyPiEQvF2= MmPPV2FPT0WU
VMRC-RCZ NHXoWHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nQU2lEPTB;Nj6wPFc4OyEQvF2= NFnGbGxUSU6JRWK=
EW-22 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe0TIhbUUN3ME22MlE6PjR7IN88US=> NWHiV|ZHW0GQR1XS
BT-474 NH;YSGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS5[GtKSzVyPU[uNlM{KM7:TR?= M3u3V3NCVkeHUh?=
BFTC-909 MkLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjObFBKSzVyPU[uN|A{PDVizszN M1vXZnNCVkeHUh?=
NB12 M4njbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDnTWM2OD14LkO5NFcyKM7:TR?= NWX0WpNTW0GQR1XS
D-263MG M1HFUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHITWM2OD14LkS1NVY6KM7:TR?= MYLTRW5ITVJ?
SNB75 NV7VcoZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjw[25KSzVyPU[uOlAyPDNizszN MXfTRW5ITVJ?
A704 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEm1Z2xKSzVyPU[uOlMxPiEQvF2= NUi0UIo4W0GQR1XS
NCI-H1693 NGm5RXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorxTWM2OD14Lk[zOlA1KM7:TR?= NYTqdHR7W0GQR1XS
LN-405 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIniUYVKSzVyPU[uO|k3PzJizszN NEnRe|NUSU6JRWK=
CHL-1 M3nSeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjRXJJKSzVyPU[uPFAxPzlizszN M4[2WXNCVkeHUh?=
A498 MlvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fqd2lEPTB;Nj64NVk3OSEQvF2= MVjTRW5ITVJ?
TE-12 NFTYUWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vERmlEPTB;Nj64N|gyPyEQvF2= MW\TRW5ITVJ?
TE-6 NVP3WZBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrKTWM2OD14LkmzNFM5KM7:TR?= NF[yeolUSU6JRWK=
AU565 M1zZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jnbWlEPTB;Nj65Olk2PyEQvF2= MkPoV2FPT0WU
RD MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnVWmJzUUN3ME22Mlk5Ojh2IN88US=> MYDTRW5ITVJ?
SW1463 MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e1fmlEPTB;Nz6xNVE3QCEQvF2= NXL0VmpVW0GQR1XS
LU-99A MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHGTWM2OD15LkG0N|IzKM7:TR?= MUjTRW5ITVJ?
NCI-H28 NFnS[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LSU2lEPTB;Nz6yPVI1KM7:TR?= MXTTRW5ITVJ?
MC-IXC NEnmO5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3Db5RKSzVyPUeuOFg2PzZizszN M365UHNCVkeHUh?=
GP5d MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTdwNEi3OlQh|ryP NE\ZfXBUSU6JRWK=
GB-1 MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjRPFZNUUN3ME23MlU1QDB2IN88US=> M2TReXNCVkeHUh?=
CAL-33 NIC5Zm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjRW4dpUUN3ME23MlY3OjN|IN88US=> MoDnV2FPT0WU
MSTO-211H NX;VRpJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEe2WGpKSzVyPUeuOlc{OzZizszN MXfTRW5ITVJ?
TE-5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTdwN{mzN|Qh|ryP NUHuUppjW0GQR1XS
D-566MG MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrDSpg4UUN3ME24MlA1PDJ7IN88US=> M4fqXXNCVkeHUh?=
JVM-3 NWe2VoVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4OzOmlEPTB;OD6xOVI3QCEQvF2= M3vXWnNCVkeHUh?=
T98G MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTrTWM2OD16LkG4NFY4KM7:TR?= MnLlV2FPT0WU
HCC1954 NGXPdYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnlTWM2OD16LkS1NVA1KM7:TR?= Mk\DV2FPT0WU
SF126 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf0TWM2OD16LkS1PVM3KM7:TR?= M{iwN3NCVkeHUh?=
LB996-RCC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlWwTWM2OD16LkWzNlU4KM7:TR?= M1nnOHNCVkeHUh?=
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NCI-H1581 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfQ[2NKSzVyPUi1MlQ3PDFizszN NEj1Vm5USU6JRWK=
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IST-MEL1 NYn4XlJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTh4Lki4O|Ih|ryP NGjISldUSU6JRWK=
KP-N-YS MmDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTh7LkmwNlgh|ryP MmDWV2FPT0WU
KYSE-410 NFfKW5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTlzLkSwOFIh|ryP NVv3bZlnW0GQR1XS
TE-10 NEPKTphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7aPINKSzVyPUmxMlU3OTFizszN MY\TRW5ITVJ?
SK-MEL-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHpTWM2OD17Mj65NVA3KM7:TR?= NYjr[4dxW0GQR1XS
COLO-792 NUC3bFVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7qTWM2OD17NT6yOVY1KM7:TR?= M{TQWHNCVkeHUh?=
SCH M1HweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDzb|k5UUN3ME25Ok4{QDd5IN88US=> Moe1V2FPT0WU
NCI-H1792 NWjjO3U{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTl4Lki5PVIh|ryP NFPUVmlUSU6JRWK=
NCI-H2029 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTl4Lkm1OlYh|ryP NIPVeYtUSU6JRWK=
SW684 NWn5dJhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv2VHJMUUN3ME25PE43PjV2IN88US=> NFfyU4JUSU6JRWK=
NCI-H209 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\DTWM2OD1zMECuNVIyKM7:TR?= MVjTRW5ITVJ?
HLE M3PoRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XCTGlEPTB;MUC1MlI5OiEQvF2= MYXTRW5ITVJ?
GOTO MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFyNz63O|ch|ryP NETBfJlUSU6JRWK=
NCI-H1793 NWfSZoVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33OeWlEPTB;MUC5MlI5KM7:TR?= MUPTRW5ITVJ?
D-392MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnDUm9PUUN3ME2xNVcvOzl6IN88US=> NXzSfYhHW0GQR1XS
SW1990 NXHCdZBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDwTWM2OD1zMkCuPVUyKM7:TR?= NEXvW2hUSU6JRWK=
ML-2 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHzbpJKSzVyPUGyNU43PzZizszN MVLTRW5ITVJ?
NCI-H2452 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTF{Mj6yNUDPxE1? MYjTRW5ITVJ?
SK-MEL-30 NIHjO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTF{Mz6yOFQh|ryP MYDTRW5ITVJ?
SN12C MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTF{ND6xO|Yh|ryP M{G4WnNCVkeHUh?=
NCI-H1770 NVfLb5pIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULQVG5yUUN3ME2xNlUvPTF2IN88US=> MUXTRW5ITVJ?
SF268 NHLHS25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECycJlKSzVyPUGyOk4yPThizszN NWfIN4NlW0GQR1XS
BALL-1 MlrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULvWJFYUUN3ME2xNlYvOjNizszN Mnq1V2FPT0WU
COLO-679 NIftVVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTF{Nj63OVMh|ryP NVmzPHZbW0GQR1XS
A2780 MnK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TGemlEPTB;MUK4Mlk5QCEQvF2= NGOySYNUSU6JRWK=
NCI-H1651 NEfqbo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonvTWM2OD1zM{GuNlQ{KM7:TR?= MXLTRW5ITVJ?
NCI-H2087 M4f2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vBc2lEPTB;MUOxMlQ5OyEQvF2= MWXTRW5ITVJ?
U-87-MG MnHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF|Mz62NFQh|ryP MmriV2FPT0WU
LB2518-MEL MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TkdWlEPTB;MUO1Mlk6OyEQvF2= NGHYRmNUSU6JRWK=
HCT-116 NF;sUnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n5OWlEPTB;MUO3MlIyPyEQvF2= NWDSd5BYW0GQR1XS
Ca9-22 MmLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;Fd2lEPTB;MUO5Mlg{OyEQvF2= MW\TRW5ITVJ?
COR-L88 NYXCb3ZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTF2Mj6xOEDPxE1? M4fNS3NCVkeHUh?=
CP50-MEL-B MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLxTWM2OD1zNESuOVAyKM7:TR?= NXrVO3p6W0GQR1XS
OVCAR-8 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF2NT62N|Yh|ryP NVHD[4lEW0GQR1XS
SK-MEL-3 NXKzN|BGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTkTWM2OD1zNEeuPFc5KM7:TR?= MlzRV2FPT0WU
GT3TKB MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fJdWlEPTB;MUS5MlkzQCEQvF2= MWLTRW5ITVJ?
KYSE-450 MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\mR4pUUUN3ME2xOVEvPTN7IN88US=> NI\MUFFUSU6JRWK=
CAPAN-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M334W2lEPTB;MUWzMlA3PCEQvF2= MoLRV2FPT0WU
BEN MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTF3Mz65Nlgh|ryP NH3EOJNUSU6JRWK=
NCI-H1304 MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPXWGNKSzVyPUG1OE43QTRizszN MmfxV2FPT0WU
KU812 NIrVdo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTF3OD62O|Qh|ryP M4HHSHNCVkeHUh?=
Capan-2 M2Hvc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\mcWlEPTB;MU[wMlU2OyEQvF2= MnK3V2FPT0WU
A673 NHjUTmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljKTWM2OD1zNkGuO|A2KM7:TR?= MmrRV2FPT0WU
SAS NFPlXXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nTTmlEPTB;MU[yMlY4QCEQvF2= NVG1d3UyW0GQR1XS
NY NXvlcYZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fEU2lEPTB;MU[1MlMyPCEQvF2= NWrkc5Y5W0GQR1XS
HCE-4 M{jJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfifJVTUUN3ME2xOlYvQDR3IN88US=> NIXsWpZUSU6JRWK=
MDA-MB-231 NYe0e4JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;mcpVOUUN3ME2xO|cvPTB|IN88US=> MYPTRW5ITVJ?
no-10 NIPjVJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXxfG5KSzVyPUG3PE4yOzRizszN NVzp[mtnW0GQR1XS
MZ7-mel MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXrSoxKSzVyPUG3PE41PjdizszN M3rYVHNCVkeHUh?=
NCI-H82 NGDjUppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnHRYFyUUN3ME2xPFAvOTZ3IN88US=> MUjTRW5ITVJ?
CAL-72 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPCSmdKSzVyPUG4OU4xPTRizszN NH2wTo9USU6JRWK=
NCI-SNU-5 Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\ibGlEPTB;MUi2Mlg1KM7:TR?= NXrMZmo1W0GQR1XS
OVCAR-4 NIi1cpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF6OD6zN|Mh|ryP M1vve3NCVkeHUh?=
SCC-9 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD3TWM2OD1zOUGg{txO NWPJWFQ1W0GQR1XS
KYSE-150 M1rPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDSTWM2OD1zOUGuPFg5KM7:TR?= NF3TcG9USU6JRWK=
HT-29 NIH3ZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\QS2lEPTB;MkCxMlIyOiEQvF2= M1HIe3NCVkeHUh?=
COLO-678 M2TmbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHF[I9KSzVyPUKwNU41PSEQvF2= MVjTRW5ITVJ?
NCI-H650 NUXBbYZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojpTWM2OD1{MEKuNVA{KM7:TR?= NHnhOXdUSU6JRWK=
HuCCT1 M{LuVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PUNWlEPTB;MkC0MlIxQCEQvF2= MojLV2FPT0WU
SW1116 M{e1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XCUGlEPTB;MkC3MlA4PyEQvF2= NYC5dmp3W0GQR1XS
DBTRG-05MG NIK1SY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13mVmlEPTB;MkC3MlkxQSEQvF2= MUPTRW5ITVJ?
SW982 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfBTWM2OD1{MEeuPVQ5KM7:TR?= M1\aSXNCVkeHUh?=
RCM-1 M{fORmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XadmlEPTB;MkG0Mlc3OiEQvF2= NILabVlUSU6JRWK=
COLO-320-HSR NGK1ZnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1X6TmlEPTB;MkG2MlEzPSEQvF2= NVHCSWxTW0GQR1XS
KNS-42 M{jJVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDYWpgyUUN3ME2yNVYvPTd2IN88US=> MlS0V2FPT0WU
C2BBe1 NYPxVlVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jmcWlEPTB;MkOxMlkxPSEQvF2= NUG1dJl[W0GQR1XS
CCRF-CEM MmDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG5SndDUUN3ME2yOFMvPzl3IN88US=> M2XzO3NCVkeHUh?=
SH-4 NHXYT5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILZZ3dKSzVyPUK0Ok4xQSEQvF2= MnvQV2FPT0WU
LS-1034 NU\zeYRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\uWWlEPTB;MkS2MlI3PiEQvF2= M2DCPXNCVkeHUh?=
NCI-H2347 M4HTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJ2Nz63NVMh|ryP M{TXPHNCVkeHUh?=
RPMI-8866 NIC5OpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJ2OT6yO{DPxE1? NVrOdZBDW0GQR1XS
GAK MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPCTWM2OD1{NUOuNFAzKM7:TR?= M4fOO3NCVkeHUh?=
NB6 NHzN[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ5MD6xJO69VQ>? NUTZVVg3W0GQR1XS
COLO-680N M1\rVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHETWM2OD1{N{KuOVI4KM7:TR?= M4Dv[nNCVkeHUh?=
RERF-LC-MS MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fCU2lEPTB;Mke2MlAxPyEQvF2= NGqyd4ZUSU6JRWK=
TGBC11TKB M3TNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHiTWM2OD1{N{iuNVc5KM7:TR?= MYrTRW5ITVJ?
C8166 M4Tr[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJ5OD61NFYh|ryP M4DHSnNCVkeHUh?=
HDLM-2 NGLpUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLoeWVsUUN3ME2yPVQvPDB7IN88US=> NFvZ[3NUSU6JRWK=
IGR-1 NW\tRY9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXkTWM2OD1{OUWuOlU6KM7:TR?= NIj0R2VUSU6JRWK=
FADU M4jFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jl[WlEPTB;Mkm3MlUyKM7:TR?= NH3lOWJUSU6JRWK=
L-428 NF\Zd4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:1T5JKSzVyPUK5O{43OTZizszN Ml7IV2FPT0WU
LU-65 NXOybFhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;hOXhmUUN3ME2zNFQvOzJizszN MUnTRW5ITVJ?
HEL M12z[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13qZ2lEPTB;M{C5Mlk5OyEQvF2= MV3TRW5ITVJ?
NCI-H810 NEnEdVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zs[WlEPTB;M{GwMlU4KM7:TR?= NFqxeYNUSU6JRWK=
C3A NG\WWVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7FdYFLUUN3ME2zNVEvQDB{IN88US=> M2PoZXNCVkeHUh?=
NCI-H630 NYntSJdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrkV|B{UUN3ME2zN|IvOjl2IN88US=> NYrjS2FoW0GQR1XS
KP-N-YN NGfkUHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFftWFZKSzVyPUO0NU4yOjNizszN MWPTRW5ITVJ?
MOLT-13 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTzdFZQUUN3ME2zOFIvOzJ4IN88US=> M{HnN3NCVkeHUh?=
NCI-H1993 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTN2Mj6zOlUh|ryP NUHibYtbW0GQR1XS
BE-13 M1nRPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTN2ND6xOlch|ryP NFf3O5lUSU6JRWK=
IST-SL1 NWDmSVI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfpTWM2OD1|NEeuOFAyKM7:TR?= NGnDNlhUSU6JRWK=
TE-9 NHjQZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTN4Mz61PFkh|ryP MX;TRW5ITVJ?
LU-135 NIH4V|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof6TWM2OD1|NkeuNFM2KM7:TR?= MoX5V2FPT0WU
T84 Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTqTWM2OD1|N{SuO|EzKM7:TR?= M4fZ[3NCVkeHUh?=
K-562 NILPRVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrPXZRtUUN3ME2zPFMvOzZizszN M2rnPHNCVkeHUh?=
SBC-5 NFuzWFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTN6Nj65PFUh|ryP MVHTRW5ITVJ?
NB17 NHq5cGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTN7Mj61PVYh|ryP MnrrV2FPT0WU
NCI-H2052 MlHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTN7OD60O|Ih|ryP NWPTU5FIW0GQR1XS
HCC38 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\ETWM2OD12MEGuOVk{KM7:TR?= MVzTRW5ITVJ?
NCI-H69 M{DxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7KTWM2OD12NEGuNFg{KM7:TR?= M4HVfXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

カスタマーフィードバック (18)


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Source , , Cell, 2015, 160(1-2): 161-76 . MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines Ser78 cells
Concentrations 5 µM
Incubation Time 1 h
Results Two selective AKT inhibitors MK-2206 and GDC-0068, both significantly reduced MKK4 phosphorylation on Ser78 in axons after injury.

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Source Cancer Cell, 2013, 24, 766-76. MK-2206 2HCl purchased from Selleck
Method analysis of luciferase activity
Cell Lines immunodeficient NOG mice
Concentrations 10 mg kg-1
Incubation Time 3 days
Results In this experiment, animalstreated with dexamethasone or MK2206 showed progressivetumor growth similar to that observed in vehicle-treated controls,while mice treated with MK2206 plus dexamethasone had significant antitumor responses.

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Source Cancer Discov, 2012, 2, 934-47. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines PC9GR4/WZR10 cells
Concentrations 1 uM
Incubation Time 72 h
Results The addition of a dual PI3K and MTOR inhibitor, PI103, or the AKT inhibitor MK-2206, did reduce the expression of pAKT neither in GR4 cells nor WZR10 cells.

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Source J Exp Med, 2014, 211(9), 1741-58. MK-2206 2HCl purchased from Selleck
Method 3D migration model
Cell Lines WT or Rap1b-/- neutrophil
Concentrations 2 uM
Incubation Time
Results MK-2206 treatment completely reversed elevated TEM across mouse endothelial cells of Rap1b-/- neutrophils to WT levels (A). It reduced ECM degradation of Rap1b -/- neutrophils, and inhibited their multiple protrusions (B and C). Furthermore, almost all Rap1b -/- cells treated with MK-2206 were found at the endothelial cell junctions (D).

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Source Nat Commun, 2015, 6:6943. MK-2206 2HCl purchased from Selleck
Method Western Blot
Cell Lines HUVECs
Concentrations 1 uM
Incubation Time 8 h
Results Because YAP is also a known substrate of Akt21, we examined whether blockade of the Akt pathway affects YAP phosphorylation. Both Ly294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and MK-2206, an allosteric inhibitor of Akt, suppressed cell contact-mediated YAP phosphorylation.

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Source Leukemia, 2015, 29(1), 169-76. MK-2206 2HCl purchased from Selleck
Method Immunoblotting
Cell Lines CXCR4S338X-expressing BCWM.1 cells
Concentrations 0.5 uM
Incubation Time 6 h
Results As AKT and ERK, but not BTK, show continued SDF-1a-triggered activation in CXCR4S338X-expressing WM cells treated with ibrutinib, we next sought to clarify if AKT and ERK contributed to the enhanced survival of these cells. It therefore treated SDF-1acultured CXCR4S338X BCWM.1 cells with either AKT- (MK-2206 and AZD-5363) or MEK- (AS-703026, AZD-6244 and UO126) specific inhibitors with and without ibrutinib (0.5 uM) for 6 h so as to clarify the contribution of AKT and ERK to ibrutinib resistance. The inhibitory activity of MK-2206, as well as AS-703026, AZD-6244 and UO126 was confirmed by western blot analysis for pAKT (S473) and pERK (T202/Y204), respectively.

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Source Cancer Res, 2013, 73, 2189-98. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines SKNAS/SJNB8/IMR32/GIMEN/SHEP2/KCNR/NGP/LAN1/LAN5/TR14/UHGNP cell lines
Concentrations 8 μM
Incubation Time 48 h
Results The 8 μM MK-2206 treatments resulted in effective pathway inhibition in all cell lines as shown by western blot for phosphoryl ated FOXO3a and PRAS40 as well as AKT serine 473 phosphorylation.

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Source Oncotarget, 2011, 2, 1109-26. MK-2206 2HCl purchased from Selleck
Method Western blot/ Wst-1 assay
Cell Lines ATC/ FTC cell lines
Concentrations 500 nM
Incubation Time 1 h/72 h
Results One-hour treatment with the AKT inhibitor MK-2206 (0.5 μM) or with the MEK inhibitor U0126 (10 μM) effectively abolished AKT and ERK1/2 phosphorylation in all cell lines.

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Source Sci Signal, 2011, 4, rs9. MK-2206 2HCl purchased from Selleck
Method ELISA
Cell Lines HeLa cells
Concentrations 1 μM
Incubation Time
Results Treatment of infected cells with kinase inhibitors directed at Akt (MK-2206), MEK(PD 98059), PKC(CEC), or Pim family kinases identified a dominant role for Pim family kinases in the release of IL-8 from Salmonella-infected epithelial cells.

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Source FASEB J, 2013, 27, 1644-56. MK-2206 2HCl purchased from Selleck
Method Clonogenic growth assay
Cell Lines U2OS cells
Concentrations 1 μM
Incubation Time 9 d
Results Specific inhibition of PKB activity using MK-2206 or triciribine also significantly reduced cell growth, although to a lesser extent compared to PI-103, suggesting that both the PKB and mTOR pathways are important for anchorage-dependent growth.

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Source Gynecol Oncol, 2011, 123, 13-8. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines ovarian cancer cell lines
Concentrations 1-6 μM
Incubation Time 1 h/72 h
Results Activation of pAKT by IGF-1 in the low-grade cell line HOC-7 was blocked by the AKT inhibitor MK-2206.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Confocal microscopy
Cell Lines platelets
Concentrations 1μM
Incubation Time
Results Upon treatment with increasing concentrations of AEA from 0.1 to 10 mM (Fig. B–D) platelets were fully fluorescently marked as compared to control (Fig. A) and the increase in DAF 2 fluorescence intensity appears to be dose-dependent. In agreement with data shown in Figure 4, SR1(Fig. E) and MK2206 (Fig. F) abolished fluorescence intensity induced by AEA, while LY294002 (Fig. 5G) was less potent.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines platelets
Concentrations 1 μM
Incubation Time
Results eNOSser1177 phosphorylation was greatly reduced by LY294002 and cancelled by MK2206 but it was not modified by platelet pretreatment with EGTA or BAPTA/AM.

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Source J Cell Biochem, 2011, 112, 924–932. MK-2206 2HCl purchased from Selleck
Method Nitriter+Nitrate(NOX) measurement, cGMP detection
Cell Lines platelets
Concentrations 1 μM
Incubation Time 1 min
Results As shown in Figure 4 SR1 significantly reduced both NOx and cGMP formation, while SR2 failed to affect these parameters.

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Source Radiat Oncol, 2009, 4, 43. MK-2206 2HCl purchased from Selleck
Method Western blot, clonogenic survival assay
Cell Lines U87MG cells
Concentrations 1 μM
Incubation Time 1 h
Results Akt inhibitor MK-2206 showed similar effect. MK-2206 is a potent allosteric Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3 respectively. U87MG cells were preincubated with 1 μM MK-2206 for 1 hr, followed by irradiation at 0 - 9 Gy. As shown in Fig C, MK-2206 treatment abolished IR-induced Akt phosphorylation. Moreover, treatment with MK-2206 also increased the radiosensitivity of U87MGcells (Fig. D)

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Source Dr. Zhang of Tianjin Medical University. MK-2206 2HCl purchased from Selleck
Method Western blot
Cell Lines Breast cancer cells
Concentrations 0-10 nM
Incubation Time 3 h
Results Breast cancer cells were serum starved for 24 h, pretreated with the indicated concentrations of MK-2206 for 3 h, and then treated with 100ng/ml EGF for 15 min.

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Source Biochim Biophys Acta, 2012, 1823, 987-96. MK-2206 2HCl purchased from Selleck
Method Immunofluorescence
Cell Lines HC11 cells
Concentrations 10 µM
Incubation Time 1 h
Results whole ADRP levels, estimated by Western blot , decreased only in the presence of MK -2206 and LY294002. In most cases, ADRP decorated the surface of small lipid droplets and appeared as little patches on large cytoplasmic lipid droplets. With the exception of SP600125, which induced a strong ADRP coating of almost all cytoplasmic lipid droplets (although this inhibitor did not increase ADRP synthesis), variation in the distribution of ADRP at the surface of lipid droplet was difficult to estimate, notably because the signal was faint and uneven.

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Source MK-2206 2HCl purchased from Selleck
Method Western blot analysis
Cell Lines MCF-7 cells
Concentrations 0 nM/100 nM/250 nM/1000 nM
Incubation Time 24 h
Results The effect of MK-2206 on the serine 473 phosphorylation mark of AKT 1 was uneven and did not correlate with inhibition of AKT activity, but the AKT1 mutant cells maintained higher levels of AKT1 serine 473 phosphorylation with increasing concentrations of MK-2206. Of note, MK-2206 completely inhibited AKT2 activation at 100 nM, a concentration where PIK3CA E545K mutant, but not AKT1 mutant cells were already strongly growth inhibited. MK-2206 treatment up to 1 μM did not have strong effects on other protein biomarkers such as ribosomal protein S6, ev en though growth was suppressed by approximately 80% in MCF-7 cells at this concentration.

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