MK-2206 2HCl

MK-2206 2HCl は一種の高選択性のAkt1/2/3阻害剤で、無細胞試験でIC50値が8 nM/12 nM/65 nMそれぞれに分かれて、250種類他のタンパク質キナーゼに抑制活性を表しません。臨床2期。

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MK-2206 2HCl 化学構造
分子量: 480.39

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MSDS

製品説明

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    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HCl は一種の高選択性のAkt1/2/3阻害剤で、無細胞試験でIC50値が8 nM/12 nM/65 nMそれぞれに分かれて、250種類他のタンパク質キナーゼに抑制活性を表しません。臨床2期。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 M2XmSWN6fG:2b4jpZ{BCe3OjeR?= M4fZflMh|ryP MkDMO|IhcA>? NVf5ZoQxTE2VTx?= MlL2TY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25? NID1XIMzODV5MUC2PS=>
A431 MYDLbY5ie2ViQYPzZZk> NVzWeGtUPSEQvF2= NFLOPZk2KGh? M3n5cGROW09? MkG2V5VxeHKnc4Pld{B1cGVic3nncoFtcW6pIH;mJGFsfCCjbnSgSZJs M4LuTlIxPTdzME[5
HepG2 NHvpbWFEgXSxdH;4bYMhSXO|YYm= NXvmdJhyOTBizszN MmXBNlQhcA>? MkDrSG1UVw>? Mke4V4Vve2m2aYrld{Bz\XOrc4ThcpQh[2WubIOgeI8hfGinIHP5eI91d3irYzDl[oZm[3Rib3[gd49z[W[nbnni NV\uboNWOjF{MEW5NlU>
Sk-Hep1 NF3hcVFEgXSxdH;4bYMhSXO|YYm= NF76RYEyOCEQvF2= M3rSOVI1KGh? Mn;iSG1UVw>? NV7uU2ZLW2Wwc3n0bZpmeyC{ZYPpd5RidnRiY3XscJMhfG9idHjlJIN6fG:2b4jpZ{Bm\m[nY4Sgc4Yhe2:{YX\lcolj MmDKNlEzODV7MkW=
OCUT1 cells harbored PIK3CA (H1047R+/+) MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy2[mc4OyEQvF2= MmPmOUBl NEjQTZRFVVOR NFPqfIdKSzVyPUCuNVQh|ryP MoTTNlEzQDl{Nke=
K1 cells harbored PIK3CA (E542K+/+) M3q2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXPWpI{KM7:TR?= MYS1JIQ> NHX3NVBFVVOR MWHJR|UxRTBwNUKg{txO MUGyNVI5QTJ4Nx?=
FTC133 cells harbored PTEN (allele deletion and R130+) M{jqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV35VZpKOyEQvF2= NED5UoM2KGR? NFznNVRFVVOR NYTTSZJVUUN3ME2wMlE5KM7:TR?= M375O|IyOjh7Mk[3
C643 cells harbored HRAS (G13R+/−) NHraR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rJRVMh|ryP NH7EbmM2KGR? M1jDWGROW09? M1nNUGlEPTB;MD6yO{DPxE1? NXvYfodJOjF{OEmyOlc>
Hth7 cells harbored NRAS (Q61R+/−) NHXVWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zreFMh|ryP NIDW[Xg2KGR? MYDEUXNQ NFy2bmJKSzVyPUSuOUDPxE1? MmjtNlEzQDl{Nke=
TPC1 cells harbored RET/PTC1 rearrangement NV;jZpZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXscpJvOyEQvF2= MlvTOUBl NFPqNoVFVVOR MULJR|UxRTBwNUmg{txO NGezSZYzOTJ6OUK2Oy=>
Hth74 NVrkRmxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXMeWc{KM7:TR?= MmLKOUBl NY\HXW9JTE2VTx?= MnrDTWM2OD1{LkG5JO69VQ>? M2exRlIyOjh7Mk[3
KAT18 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TiN|Mh|ryP NXn1XlZMPSCm NHvs[VdFVVOR MVXJR|UxRTRwNkKg{txO NFi1OZUzOTJ6OUK2Oy=>
SW1736 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPZNVAxKM7:TR?= MV:1JIQ> NWDnWoN[TE2VTx?= M1nwPWlEPTB;NEeuOVYh|ryP MUCyNVI5QTJ4Nx?=
WRO NHjWbnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKzfWcyODByIN88US=> MYO1JIQ> NXznNFVKTE2VTx?= MVTJR|UxRjFyMECg{txO Ml62NlEzQDl{Nke=
TAD2 NEjPe2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3y3[FExODBizszN MYC1JIQ> MXjEUXNQ NWTXWm5tUUN3ME6xNFAxKM7:TR?= MlnlNlEzQDl{Nke=
LN229 NWOw[llQSXCxcITvd4l{KEG|c3H5 M{D1RVAvPSEQvF2= NIX2OYk3OCCq NVvQWlB3TE2VTx?= MXHBeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? MkWyNlIxPTd7MUS=
T98G NHSzVZhCeG:ydH;zbZMhSXO|YYm= NGfx[G4xNjVizszN MnrEOlAhcA>? M{fzN2ROW09? MUHBeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? NGfJPYUzOjB3N{mxOC=>
HC11 MlTXSpVv[3Srb36gRZN{[Xl? M2\MSVExKM7:TR?= NFXFWoYzPCCq NYm1PJhJTE2VTx?= NHHQc2hKdmirYnn0d{DPui2lYYPlbY4h[W6mIFHEVnAhe3mwdHjld4l{ NH;hW5YzOjR{Nk[yNS=>
MOLT-4 M3zacmN6fG:2b4jpZ{BCe3OjeR?= NYflTHozOTBizszN MlzyOFghcA>? M2f5cGROW09? MV;JR|UxRTFwN,MAje69VQ>? M1LvZlIzPjF2MkSz
CEM-R M1OwfWN6fG:2b4jpZ{BCe3OjeR?= NFG4WHkyOCEQvF2= NYHLdpN[PDhiaB?= M{\5d2ROW09? M1S2O2lEPTB;Mz6z5qCK|ryP MViyNlYyPDJ2Mx?=
CEM-S NELMV3VEgXSxdH;4bYMhSXO|YYm= MoDQNVAh|ryP M4X6cFQ5KGh? MVTEUXNQ MlvrTWM2OD13LkJihKnPxE1? NUHBVHlLOjJ4MUSyOFM>
MOLT-4 MleySpVv[3Srb36gRZN{[Xl? MlGwNVAh|ryP MX[yOEBp M3nYSWROW09? MofDRoxw[2u|IHPlcIx{KGmwIITo[UBIOC:JMTDwbIF{\SCxZjD0bIUh[2WubDDjfYNt\Q>? MWmyNlYyPDJ2Mx?=
MOLT-4 MmjTSpVv[3Srb36gRZN{[Xl? M1nkc|TjiIoQvF2= M1WzXVQhcA>? MUPEUXNQ NXnUe2tSUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|NCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ MoHMNlI3OTR{NEO=
CEM-R M37sOmZ2dmO2aX;uJGF{e2G7 MoTNOQKBkc7:TR?= NWj4XJN[PCCq MXrEUXNQ NGrVfItKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDOGEwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? NUT2ZZUzOjJ4MUSyOFM>
CEM-S MXTGeY5kfGmxbjDBd5NigQ>? M{DGfVTjiIoQvF2= NITINVc1KGh? MV7EUXNQ M1:3T2lv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFO1RU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? NF3Qd2gzOjZzNEK0Ny=>
HepG2 cell NWTrZYROU2mwYYPlJGF{e2G7 NIjqW4kzOCEQvF2= MojxNlQhcA>? NU[0RnBETE2VTx?= M17FfGRwf26{ZXf1cIF1\XNidHjlJJBpd3OyaH;yfYxifGmxbjDv[kBCU1R? M4Dz[|I{Pzl5M{G5
HepG2 cell NH7LSYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHSxb|I{OCEQvF2= NUjre|U2OjRiaB?= NUHTV294TE2VTx?= NVjhbVhRUW6qaXLpeJMh[2WubDDndo94fGh? M17jclI{Pzl5M{G5
HepG2 cell M4T3ZWFxd3C2b4Ppd{BCe3OjeR?= NYHrdmk4OjBizszN M1\kXlI1KGh? NHjwZXlFVVOR M{HidWlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? NGfvRWgzOzd7N{OxPS=>
GEO NILNR5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorXOVAxKG6P NE\Mfow4OiCq MX7EUXNQ MUTJcohq[mm2czDj[YxtKGe{b4f0bC=> MmXSNlQ2QDF{M{G=
CNE-1 MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jwfFExKM7:TR?= NWP4RmpLQTZiaB?= M1zrPWROW09? NETXcG1KSzVyPUKuPVYh|ryP MV:yOVM{Pjl{NR?=
CNE-2 NGnFfXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKxUppVOTBizszN NFm4bYs6PiCq NHnabHJFVVOR MXTJR|UxRTRwNUOg{txO MlvYNlU{OzZ7MkW=
HONE-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIO1W4syOCEQvF2= NELn[ZM6PiCq M3fVemROW09? NX70ZXlrUUN3ME2zMlM4KM7:TR?= NF\JSmMzPTN|NkmyOS=>
SUNE-1 NIrsU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vSfFExKM7:TR?= M1jMWlk3KGh? MVjEUXNQ Mlr0TWM2OD1yLkWyJO69VQ>? NGHMN5UzPTN|NkmyOS=>
CNE-2 NVLTOoZpTnWwY4Tpc44hSXO|YYm= MWmxNEDPxE1? NX7tdI1oPDhiaB?= Mk\LSG1UVw>? MXjJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy NFjZfVMzPTN|NkmyOS=>
HONE-1 MUnGeY5kfGmxbjDBd5NigQ>? MnfJNVAh|ryP NEXuTnc1QCCq MWjEUXNQ NF3hdWVKdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0JIF1KEdz MVOyOVM{Pjl{NR?=
NEC8 NUn0S41vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEm2OVEh|ryP MVHTRW5ITVJ?
P12-ICHIKAWA MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELqWGpKSzVyPUCuNVE3OiEQvF2= MUPTRW5ITVJ?
MDA-MB-175-VII MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rlTGlEPTB;MD6xN|c{QCEQvF2= M4[xUnNCVkeHUh?=
AsPC-1 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP4eppbUUN3ME2wMlIzOTJ{IN88US=> M{LV[XNCVkeHUh?=
T47D NIHXb49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M333O2lEPTB;MD6yPFI2KM7:TR?= MojDV2FPT0WU
HH NWXvbIt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P3SGlEPTB;MD6zNFI5OyEQvF2= MXXTRW5ITVJ?
MOLT-16 MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjkZ5hKSzVyPUCuN|A{OiEQvF2= MVzTRW5ITVJ?
ES5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrNTWM2OD1yLkO0OFU2KM7:TR?= M2jWNXNCVkeHUh?=
RS4-11 M{PJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDzZ25KSzVyPUCuN|Q3OSEQvF2= MXHTRW5ITVJ?
KARPAS-45 M{f5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwM{ezNlEh|ryP M{\U[nNCVkeHUh?=
NCI-H720 NWDpVlBnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjMTWM2OD1yLkO3Olc6KM7:TR?= MoPaV2FPT0WU
H9 MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHCVmdKSzVyPUCuN|g5QDNizszN NHe5UHJUSU6JRWK=
EFM-19 M3HscWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TjXmlEPTB;MD60OFAyKM7:TR?= M3n3c3NCVkeHUh?=
SBC-1 MmLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1noOGlEPTB;MD60OFA{PSEQvF2= MmCxV2FPT0WU
A4-Fuk M17uXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwNE[4Olgh|ryP MnXyV2FPT0WU
NCI-H1563 MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPvcXc4UUN3ME2wMlQ5OTh7IN88US=> Mk\tV2FPT0WU
HCC1419 NXHlUnNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXkTIdbUUN3ME2wMlQ5QDl{IN88US=> NUSxeXdrW0GQR1XS
H-EMC-SS NVn0c5ZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIi4b3NKSzVyPUCuOFk6OzlizszN Mmi2V2FPT0WU
BHT-101 M16xUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3IS4VKSzVyPUCuOVI6PjFizszN MUHTRW5ITVJ?
IGROV-1 M3TxeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe5TWM2OD1yLkW1NlQ6KM7:TR?= MWLTRW5ITVJ?
HGC-27 NFfyVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\ITWM2OD1yLkW2O|g{KM7:TR?= MkfjV2FPT0WU
MDA-MB-361 NYG1fIRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfN[5pKSzVyPUCuOVc4PjFizszN MmfUV2FPT0WU
KE-37 NWTRSmpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwNUiyOkDPxE1? M3\NSnNCVkeHUh?=
HCC70 NELBW3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHVXFNoUUN3ME2wMlU6QDJ5IN88US=> NFLwPG1USU6JRWK=
LNCaP-Clone-FGC Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;aNmlEPTB;MD62NVA1QCEQvF2= NITWN4dUSU6JRWK=
HAL-01 NG\HZYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnLZlZKSzVyPUCuOlIyOyEQvF2= NF;QeIhUSU6JRWK=
HT MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoW0TWM2OD1yLk[zNlM6KM7:TR?= MWfTRW5ITVJ?
MDA-MB-415 MljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TudmlEPTB;MD62N|YzPiEQvF2= MXvTRW5ITVJ?
NOS-1 NFjxNphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXETWM2OD1yLk[zO|I{KM7:TR?= NYfJXZhsW0GQR1XS
DU-145 NV7PNo54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXDTHFKSzVyPUCuOlQ4PDVizszN NGfncppUSU6JRWK=
OCUB-M MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\ZT2lEPTB;MD63NFk3PiEQvF2= MX;TRW5ITVJ?
VA-ES-BJ MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfiRWx3UUN3ME2wMlc{ODJ3IN88US=> MlzyV2FPT0WU
J-RT3-T3-5 M1nFbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XifWlEPTB;MD63OFQxOyEQvF2= NGPKfY9USU6JRWK=
MOLT-4 NEfybY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnudYFKSzVyPUCuPFA2QDJizszN Ml3wV2FPT0WU
NB7 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwOEK0NVEh|ryP MlToV2FPT0WU
L-363 NHHMV5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv0RVZZUUN3ME2wMlg{PDR{IN88US=> NEHtVHBUSU6JRWK=
NKM-1 MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfhWVlKSzVyPUCuPFYzPTNizszN NWPZRmFIW0GQR1XS
HOP-92 NH3pbFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fDdmlEPTB;MD64O|IzOyEQvF2= M2HzdHNCVkeHUh?=
OAW-42 M3GwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\Xb3JKSzVyPUCuPFg4OiEQvF2= NX3XboV[W0GQR1XS
HuO9 NFP3eG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\uN3VDUUN3ME2wMlkzPzVzIN88US=> M1fIWHNCVkeHUh?=
MFE-280 NVT6VJNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorWTWM2OD1yLkm2OFY2KM7:TR?= NHvjZVZUSU6JRWK=
EM-2 NWTLUJBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrOUolKSzVyPUCuPVc6OzlizszN MUfTRW5ITVJ?
NCI-H520 MkLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLFR|JZUUN3ME2wMlk5PTl{IN88US=> M2C3UnNCVkeHUh?=
LB2241-RCC MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwOUm3N|Qh|ryP MoLtV2FPT0WU
SK-NEP-1 Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zyNmlEPTB;MT6xOFQ5PSEQvF2= M{LOXXNCVkeHUh?=
LXF-289 NXrJbVlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrIZ3QzUUN3ME2xMlE4OTV4IN88US=> M3LsSHNCVkeHUh?=
EPLC-272H NEXxZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTRTWM2OD1zLkG3NlU3KM7:TR?= Mo\BV2FPT0WU
COLO-684 M4LWR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvCS5E4UUN3ME2xMlI{PzJ3IN88US=> NFfa[VVUSU6JRWK=
ES1 M3HpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFwMkSwOlUh|ryP MV;TRW5ITVJ?
DOHH-2 NHXGWHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3YTWM2OD1zLkK4NlA{KM7:TR?= MnTxV2FPT0WU
CTB-1 M{\Gfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W3U2lEPTB;MT6yPFk6KM7:TR?= MYXTRW5ITVJ?
G-401 NEHifGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnZO41IUUN3ME2xMlI6Pzl3IN88US=> M1fpR3NCVkeHUh?=
LoVo MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwM{K1N|Qh|ryP MVXTRW5ITVJ?
Ramos-2G6-4C10 NUHsdnVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jVOGlEPTB;MT6zN|cxOSEQvF2= MmfqV2FPT0WU
MFM-223 NX\BUI8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDVVGxKUUN3ME2xMlM1PDZzIN88US=> NFvt[|JUSU6JRWK=
PA-1 M3;3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn20TWM2OD1zLkO1NlY2KM7:TR?= M3zhPXNCVkeHUh?=
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D-566MG NEDFNFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRThwMES0Nlkh|ryP M3\3UHNCVkeHUh?=
JVM-3 NEXjO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7ycJA1UUN3ME24MlE2OjZ6IN88US=> MUHTRW5ITVJ?
T98G MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRThwMUiwOlch|ryP NXrrXWU1W0GQR1XS
HCC1954 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRThwNEWxNFQh|ryP NGTONmtUSU6JRWK=
SF126 M2XFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRThwNEW5N|Yh|ryP M2jWcnNCVkeHUh?=
LB996-RCC M3XNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRThwNUOyOVch|ryP NGD3NZZUSU6JRWK=
SKG-IIIa M4XIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu3fpJHUUN3ME24MlY{ODZ7IN88US=> MVvTRW5ITVJ?
NCI-SNU-1 NH\kbXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jCOWlEPTB;OD62OFY1OyEQvF2= Mn[yV2FPT0WU
LB771-HNC NInxPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID4S|lKSzVyPUiuOlQ3QTZizszN MkXnV2FPT0WU
SCC-4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfsZ2hCUUN3ME24MlY5OjF7IN88US=> MljmV2FPT0WU
CAMA-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTRd|RKSzVyPUiuO|cyPDZizszN NHPSU3NUSU6JRWK=
D-502MG MlLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn1THVNUUN3ME24Mlc5PjJ7IN88US=> Mn70V2FPT0WU
ESS-1 M4S1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnh[odKSzVyPUiuPFg4ODRizszN NXrEZ4ZmW0GQR1XS
HEC-1 MorZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnGTWM2OD16Lki5PFY3KM7:TR?= NHHqOHhUSU6JRWK=
NB10 MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37YeWlEPTB;OT6wNlIzPCEQvF2= NHy5XZRUSU6JRWK=
8505C MmOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K5cWlEPTB;OT6wOFI{OiEQvF2= NI\sdodUSU6JRWK=
EFO-27 MlfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHvWIxKSzVyPUmuNVY1OTJizszN MnvrV2FPT0WU
HN MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTlwMU[2Nlgh|ryP NGHKO5pUSU6JRWK=
DSH1 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTlwMkC4O{DPxE1? NHz4UGVUSU6JRWK=
NBsusSR MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXtTWM2OD17LkK3OFAzKM7:TR?= M{TTd3NCVkeHUh?=
LS-123 M3GyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDwSohyUUN3ME25MlMyPzZzIN88US=> M3f2SHNCVkeHUh?=
SHP-77 M4jueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LOdWlEPTB;OT6zPVk{PSEQvF2= M17Ud3NCVkeHUh?=
ACN NV6zbHRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPqTWM2OD17LkWzNlc4KM7:TR?= MoC1V2FPT0WU
U251 NUD0[lN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nK[2lEPTB;OT62OVU1PCEQvF2= MUnTRW5ITVJ?
A431 M1PFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmX4TWM2OD17LkiwNlM5KM7:TR?= M3jvVnNCVkeHUh?=
5637 MkXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTtRpBHUUN3ME25Mlg1QTh2IN88US=> M3XISHNCVkeHUh?=
MDA-MB-157 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TnZ2lEPTB;OT65Nlg4QCEQvF2= MUTTRW5ITVJ?
A101D NHvoRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjxb2hlUUN3ME25Mlk6QTd2IN88US=> MmjTV2FPT0WU
YKG-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETzTWNKSzVyPUGwMlIxODZizszN M2\KOnNCVkeHUh?=
LAN-6 NXLDSm1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\jfXh{UUN3ME2xNE4zOTZ2IN88US=> NWPJOmN1W0GQR1XS
OVCAR-5 NVX0OlFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV64cplRUUN3ME2xNE4zPDN|IN88US=> NYHCTnZVW0GQR1XS
A549 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTFyLkO5O|Mh|ryP NU\pfmFPW0GQR1XS
no-11 M2LNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfLTWM2OD1zMD60N|U{KM7:TR?= MmXsV2FPT0WU
SF539 NY\vV5Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHruTGdKSzVyPUGwMlkxPDFizszN MUDTRW5ITVJ?
A388 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHNcGhKSzVyPUGxMlM5QTdizszN NX7nTGZYW0GQR1XS
DEL M{LZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHry[GJKSzVyPUGxMlQzPCEQvF2= MVvTRW5ITVJ?
SW954 NEHoPVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:zRo5{UUN3ME2xNU41PjZ6IN88US=> NGPMN|BUSU6JRWK=
TK10 MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\wdmlEPTB;MUGuOVI4OSEQvF2= MWfTRW5ITVJ?
SW756 M13YWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrVTXlKSzVyPUGxMlUzQTRizszN MWLTRW5ITVJ?
PC-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\nPHpGUUN3ME2xNU42PzZ2IN88US=> NWrQe4lmW0GQR1XS
ONS-76 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rGWWlEPTB;MUGuOlM3KM7:TR?= MYfTRW5ITVJ?
A427 NUi3VlBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFzLkewPVMh|ryP MYDTRW5ITVJ?
MEG-01 NXf2Sm13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPWTWM2OD1zMT63OVA6KM7:TR?= MlPnV2FPT0WU
BB30-HNC M4P4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7TTWM2OD1zMT63PVgzKM7:TR?= MVXTRW5ITVJ?
NCI-H1299 MnzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvFS29KSzVyPUGxMlgxQTNizszN NEm3WWFUSU6JRWK=
GCT NXvGb441T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqzZXVVUUN3ME2xNU45OjJ6IN88US=> M3K4dHNCVkeHUh?=
D-247MG M3nBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTFzLkm2OlMh|ryP NFjodlhUSU6JRWK=
CFPAC-1 NFXiNpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{CwUWlEPTB;MUGuPVc5OiEQvF2= NVj0SGltW0GQR1XS
EKVX MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L5bmlEPTB;MUKuNFMyOyEQvF2= NIi4dYdUSU6JRWK=
CAL-51 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j2S2lEPTB;MUKuNFcyPiEQvF2= NY\qblJVW0GQR1XS
BB49-HNC M4DSWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MliyTWM2OD1zMj6xNVc4KM7:TR?= NIfZeGlUSU6JRWK=
RPMI-7951 M1fVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfySJZKSzVyPUGyMlE5PTRizszN NHvqfoNUSU6JRWK=
RH-1 MofkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jqV2lEPTB;MUKuNlE5PCEQvF2= NFfPV3hUSU6JRWK=
BCPAP M3vKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIj0WGVKSzVyPUGyMlQ4PDlizszN MWjTRW5ITVJ?
GCIY Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLJRZRTUUN3ME2xNk42OjB7IN88US=> MYHTRW5ITVJ?
KNS-81-FD NYjHbnlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrUPWhKSzVyPUGyMlU5PjlizszN MVHTRW5ITVJ?
KYSE-140 NHn0UppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;lRWlEPTB;MUKuPFU6PSEQvF2= NUCwUJFzW0GQR1XS
Ca-Ski MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF{LkmwOFEh|ryP M3yweXNCVkeHUh?=
TGBC1TKB M3jvSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoW5TWM2OD1zMj65NVE2KM7:TR?= M3L0dnNCVkeHUh?=
HCC1187 NYn2WWZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[xTWM2OD1zMz6xPVEzKM7:TR?= NV:wUmhsW0GQR1XS
SJSA-1 NH[5eGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f6fmlEPTB;MUOuNlMzPyEQvF2= M2LGdHNCVkeHUh?=
CTV-1 NGDncYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[3fGlEPTB;MUOuN|Q2KM7:TR?= MnjCV2FPT0WU
WM-115 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m3O2lEPTB;MUOuOlQ5OyEQvF2= NX3vO4VYW0GQR1XS
CHP-212 NHTITW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3BTWM2OD1zMz65O|M6KM7:TR?= M3jGT3NCVkeHUh?=
SCC-15 M3;ENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHldGxkUUN3ME2xN{46Pzd3IN88US=> M1m4[XNCVkeHUh?=
BPH-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrWPYxNUUN3ME2xOE4yPjZ2IN88US=> MWfTRW5ITVJ?
SW780 MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofDTWM2OD1zND61NFI2KM7:TR?= Mke5V2FPT0WU
NCI-H2291 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37xOmlEPTB;MUSuOVg4QCEQvF2= MU\TRW5ITVJ?
JEG-3 M37WUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnUeZNKSzVyPUG0MlY{OjZizszN MULTRW5ITVJ?
CAL-120 NFqzVIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF2LkewNlch|ryP NGPWSolUSU6JRWK=
NCI-H23 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTF2Lke5PVch|ryP MYHTRW5ITVJ?
MS-1 NIXNNYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TPXWlEPTB;MUSuPVYyOSEQvF2= MVrTRW5ITVJ?
PC-14 M2jTVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXm0O5JnUUN3ME2xOE46PjV2IN88US=> MoC2V2FPT0WU
D-283MED M3HBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDYTWM2OD1zNT6wNVEyKM7:TR?= NXP2XINLW0GQR1XS
OE19 M2DSVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPicndZUUN3ME2xOU4yPTRzIN88US=> MljDV2FPT0WU
CAS-1 NGHrdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWG1XGg1UUN3ME2xOU41OTh2IN88US=> NVT4d4w2W0GQR1XS
NCI-H727 M2LBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXIfHNKSzVyPUG1MlQzOjFizszN MmPVV2FPT0WU
SiHa MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r1cmlEPTB;MUWuO|U6PCEQvF2= NXvrUYZlW0GQR1XS
BFTC-905 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDhblhKSzVyPUG1Mlc3QTRizszN M3rGfHNCVkeHUh?=
MDA-MB-453 NYCxbJNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\CeWlEPTB;MU[uNVY1OiEQvF2= MnjyV2FPT0WU
HuP-T3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDzeYFiUUN3ME2xOk43Ozd|IN88US=> M{j6UXNCVkeHUh?=
SK-LU-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjsRWt5UUN3ME2xOk43QTV4IN88US=> Moj0V2FPT0WU
Detroit562 M{DDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTF4LkezNVgh|ryP MnXpV2FPT0WU
HCC1569 M165Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTF4LkizN|ch|ryP NUm5[|F5W0GQR1XS
SK-MES-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTF4Lki0NVkh|ryP M2jBUXNCVkeHUh?=
BB65-RCC NH\tNGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXLXHRkUUN3ME2xO{4xPDd7IN88US=> MVTTRW5ITVJ?
LOXIMVI M1vFSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTF5LkC3NFch|ryP MkTsV2FPT0WU
SW1783 NVPiVo9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXt[o1KSzVyPUG3MlEzQCEQvF2= MonWV2FPT0WU
NH-12 M{PFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV30N5JWUUN3ME2xO{4{OzB|IN88US=> NXPiNId3W0GQR1XS
UACC-257 NFfkUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD2NZljUUN3ME2xO{42PTF{IN88US=> M4jMVHNCVkeHUh?=
KOSC-2 NHziOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTMTWM2OD1zNz62O|U4KM7:TR?= M2PWOHNCVkeHUh?=
KG-1 NF:1UmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHHZo9MUUN3ME2xO{43QTN5IN88US=> M1\a[3NCVkeHUh?=
M059J MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\neGlEPTB;MUeuO|A{KM7:TR?= NHrlV2NUSU6JRWK=
MHH-NB-11 NIT4VlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjvfJJyUUN3ME2xO{46Pjd|IN88US=> MlfQV2FPT0WU
EW-1 NXf5O5lXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF6LkGzPFIh|ryP MlLuV2FPT0WU
CAL-85-1 MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfjdW1KSzVyPUG4MlI{PTdizszN MWLTRW5ITVJ?
639-V NH\DcmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrTTWM2OD1zOD6zN|U1KM7:TR?= MVrTRW5ITVJ?
C32 NGflbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTF6LkS3Nlch|ryP NYi2fG1YW0GQR1XS
KM-H2 M4rkcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fuXWlEPTB;MUiuOVI{OiEQvF2= NXnibpZLW0GQR1XS
A253 NHnI[|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDTcIVKSzVyPUG4MlczQDZizszN Moi4V2FPT0WU
NCI-N87 NXvPNHdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG2d2JKSzVyPUG4MlkxODhizszN MWrTRW5ITVJ?
8-MG-BA MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF7LkC2OFYh|ryP M2O0N3NCVkeHUh?=
GI-ME-N MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTF7LkG1OFYh|ryP NUfMb2hjW0GQR1XS
8305C MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2m1d2lEPTB;MUmuNlI5PiEQvF2= M4S3[XNCVkeHUh?=
TE-8 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\H[JRyUUN3ME2xPU4{ODJ2IN88US=> NWjPdGNJW0GQR1XS
KYSE-270 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJyLkCyNVch|ryP M1jvZ3NCVkeHUh?=
HL-60 NFfv[nhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJyLkC5OFEh|ryP MnnIV2FPT0WU
Mo-T NE\KWXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJyLkG2OlUh|ryP MUfTRW5ITVJ?
NCI-H1355 M2TqV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVW1d4hrUUN3ME2yNE4{Ozd2IN88US=> M1TYb3NCVkeHUh?=
HT-1080 NXHq[JV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G2b2lEPTB;MkCuOVQ6PyEQvF2= MkT0V2FPT0WU
MIA-PaCa-2 MlmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHYToF5UUN3ME2yNE43QDh|IN88US=> NFn4TotUSU6JRWK=
NCI-H441 NV7oPI1PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJyLkezO|kh|ryP MlvUV2FPT0WU
LCLC-97TM1 M2TyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33memlEPTB;MkCuPFE{PCEQvF2= MYrTRW5ITVJ?
HT-3 Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJzLkW2N|Eh|ryP M3fuWXNCVkeHUh?=
22RV1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TwT2lEPTB;MkGuOVY5PSEQvF2= NX\VcGFEW0GQR1XS
LK-2 M4TJVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jaVGlEPTB;MkGuOVk2OyEQvF2= NEXOd3FUSU6JRWK=
CW-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIqwcGFKSzVyPUKxMlYxPjlizszN MYHTRW5ITVJ?
KYSE-510 M4fiUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWqwT4FuUUN3ME2yNU43ODl3IN88US=> Mn3oV2FPT0WU
CGTH-W-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfpNGFKSzVyPUKxMlcyPjZizszN NFz3VHVUSU6JRWK=
NCI-H661 NFLOZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDsVWxKSzVyPUKyMlA{PCEQvF2= MUTTRW5ITVJ?
KU-19-19 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLlTWM2OD1{Mj6xOlk4KM7:TR?= NHTjVoJUSU6JRWK=
NCI-H2122 NVXOZpR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJ{LkK0N|Ih|ryP M2jZSHNCVkeHUh?=
NCI-H526 M4OzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7wTWM2OD1{Mj6zPFk2KM7:TR?= NWTYb5JYW0GQR1XS
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SW1990 NVTIV255T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;X[pZjUUN3ME2xNlAvQTVzIN88US=> NGHQO|BUSU6JRWK=
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SN12C MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3vbINKSzVyPUGyOE4yPzZizszN MoKxV2FPT0WU
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COR-L88 M3;FUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTF2Mj6xOEDPxE1? Mm\KV2FPT0WU
CP50-MEL-B NFvWOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HSTmlEPTB;MUS0MlUxOSEQvF2= M2DvTXNCVkeHUh?=
OVCAR-8 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF2NT62N|Yh|ryP MVnTRW5ITVJ?
SK-MEL-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;td4NvUUN3ME2xOFcvQDd6IN88US=> M3HaZ3NCVkeHUh?=
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KYSE-450 NETjPGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPITWM2OD1zNUGuOVM6KM7:TR?= NU\4OYxKW0GQR1XS
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NCI-H1304 NFzL[IdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT5ZVdiUUN3ME2xOVQvPjl2IN88US=> NVnPeG41W0GQR1XS
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SAS MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF4Mj62O|gh|ryP NYPVRZdXW0GQR1XS
NY M2H3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF4NT6zNVQh|ryP Mlr5V2FPT0WU
HCE-4 MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETBN4tKSzVyPUG2Ok45PDVizszN M2CxS3NCVkeHUh?=
MDA-MB-231 M2\2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfkTWM2OD1zN{euOVA{KM7:TR?= MXvTRW5ITVJ?
no-10 NWDBbIxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHu5UnNKSzVyPUG3PE4yOzRizszN MoKzV2FPT0WU
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NCI-H82 NX:xVFZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLOTWM2OD1zOECuNVY2KM7:TR?= NHTK[YlUSU6JRWK=
CAL-72 M121RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF6NT6wOVQh|ryP Ml[wV2FPT0WU
NCI-SNU-5 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF6Nj64OEDPxE1? MUjTRW5ITVJ?
OVCAR-4 M2jkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[3WGlEPTB;MUi4MlM{OyEQvF2= NWLYe2FsW0GQR1XS
SCC-9 NUDXcHYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X3TWlEPTB;MUmxJO69VQ>? M2HHXnNCVkeHUh?=
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HT-29 NHvY[WlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHZTWM2OD1{MEGuNlEzKM7:TR?= NGXkcGlUSU6JRWK=
COLO-678 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHX1UI9KSzVyPUKwNU41PSEQvF2= M2DQNHNCVkeHUh?=
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HuCCT1 NFHGXYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJyND6yNFgh|ryP MoXZV2FPT0WU
SW1116 NU\BfGh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjvVXZKSzVyPUKwO{4xPzdizszN M1XDSHNCVkeHUh?=
DBTRG-05MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLnb2lmUUN3ME2yNFcvQTB7IN88US=> Mnf6V2FPT0WU
SW982 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTJyNz65OFgh|ryP MYLTRW5ITVJ?
RCM-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJzND63OlIh|ryP NGjv[XhUSU6JRWK=
COLO-320-HSR NGLTdnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;t[WhKSzVyPUKxOk4yOjVizszN NWnZOlFyW0GQR1XS
KNS-42 NYPjTmtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPScVdrUUN3ME2yNVYvPTd2IN88US=> MUPTRW5ITVJ?
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CCRF-CEM NGPldm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHUTWM2OD1{NEOuO|k2KM7:TR?= M17Cc3NCVkeHUh?=
SH-4 NY\1co1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJ2Nj6wPUDPxE1? MmX5V2FPT0WU
LS-1034 NHuw[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInUfXZKSzVyPUK0Ok4zPjZizszN MnLBV2FPT0WU
NCI-H2347 M4Dxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ2Nz63NVMh|ryP Mn3pV2FPT0WU
RPMI-8866 NF7hSGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJ2OT6yO{DPxE1? NHj4bXZUSU6JRWK=
GAK MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u4dmlEPTB;MkWzMlAxOiEQvF2= NH;HZ5NUSU6JRWK=
NB6 M3;PSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PH[mlEPTB;MkewMlEh|ryP MYfTRW5ITVJ?
COLO-680N M1XQfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnjZ|hKSzVyPUK3Nk42OjdizszN MXzTRW5ITVJ?
RERF-LC-MS MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrwcXRbUUN3ME2yO|YvODB5IN88US=> MYnTRW5ITVJ?
TGBC11TKB MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHJXYZrUUN3ME2yO|gvOTd6IN88US=> NF\tS|lUSU6JRWK=
C8166 NHWyepBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJ5OD61NFYh|ryP M1\BS3NCVkeHUh?=
HDLM-2 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO4eJhYUUN3ME2yPVQvPDB7IN88US=> NVPGe2JsW0GQR1XS
IGR-1 M13ubGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTJ7NT62OVkh|ryP MV3TRW5ITVJ?
FADU NYTLcGlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[wcmkxUUN3ME2yPVcvPTFizszN NVGzb48zW0GQR1XS
L-428 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi5WHNEUUN3ME2yPVcvPjF4IN88US=> Mmi3V2FPT0WU
LU-65 M4\uemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTNyND6zNkDPxE1? MU\TRW5ITVJ?
HEL NIrvfFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[0W4VKSzVyPUOwPU46QDNizszN MVzTRW5ITVJ?
NCI-H810 NUiwTVRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTNzMD61O{DPxE1? MYLTRW5ITVJ?
C3A MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLrUZh{UUN3ME2zNVEvQDB{IN88US=> NHfCXIRUSU6JRWK=
NCI-H630 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfpfYZIUUN3ME2zN|IvOjl2IN88US=> MXXTRW5ITVJ?
KP-N-YN M1Gze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjUWYhKSzVyPUO0NU4yOjNizszN M2jLcXNCVkeHUh?=
MOLT-13 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;QNVM6UUN3ME2zOFIvOzJ4IN88US=> MknvV2FPT0WU
NCI-H1993 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XKfGlEPTB;M{SyMlM3PSEQvF2= NELRWodUSU6JRWK=
BE-13 NWPINVRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTN2ND6xOlch|ryP M4TiNXNCVkeHUh?=
IST-SL1 M2DpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLhTWM2OD1|NEeuOFAyKM7:TR?= NE\uTZhUSU6JRWK=
TE-9 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnJUotKSzVyPUO2N{42QDlizszN NIO2S|FUSU6JRWK=
LU-135 NFPTVXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN4Nz6wN|Uh|ryP NVTveW5MW0GQR1XS
T84 M4XPVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nRd2lEPTB;M{e0MlcyOiEQvF2= NX;HdGZpW0GQR1XS
K-562 NWDiW4dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fhWGlEPTB;M{izMlM3KM7:TR?= MnWzV2FPT0WU
SBC-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvHOVdVUUN3ME2zPFYvQTh3IN88US=> NWDZdo5OW0GQR1XS
NB17 NFvxdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli0TWM2OD1|OUKuOVk3KM7:TR?= M4HSUnNCVkeHUh?=
NCI-H2052 MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD2TYV3UUN3ME2zPVgvPDd{IN88US=> NI\VT2lUSU6JRWK=
HCC38 NFfRUYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;hTWM2OD12MEGuOVk{KM7:TR?= MlnlV2FPT0WU
NCI-H69 M3\EV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnVR21KSzVyPUS0NU4xQDNizszN MnzZV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

文献中の引用 (179)

Frequently Asked Questions

  • Question 1
    I would want to know if MK-2206 could cross the blood brain barrier?

    Answer: MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

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