MK-2206 2HCl 化学構造
分子量: 480.39

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Quality Control & MSDS

製品説明

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    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HClは高度選択的に Akt1, Akt2 and Akt3を抑制して、 IC50がそれぞれ 8 nM, 12 nM と 65 nMになる。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 M1\jU2N6fG:2b4jpZ{BCe3OjeR?= MoPDN{DPxE1? MXW3NkBp MmXKSG1UVw>? NX;rPZZqUW6qaXLpeIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36= NFLhRXgzODV5MUC2PS=>
A431 NHuy[lJMcW6jc3WgRZN{[Xl? Ml\ROUDPxE1? NVfwPGhzPSCq MnfuSG1UVw>? NUnDXFhyW3WycILld5NmeyC2aHWgd4lodmGuaX7nJI9nKEGtdDDhcoQhTXKt M2n3W|IxPTdzME[5
HepG2 NIfzfHJEgXSxdH;4bYMhSXO|YYm= NX\1ZVN2OTBizszN M3fkRlI1KGh? MUTEUXNQ M4XRSHNmdnOrdHn6[ZMhemW|aYP0ZY51KGOnbHzzJJRwKHSqZTDjfZRwfG:6aXOg[YZn\WO2IH;mJJNwemGoZX7pZi=> Ml75NlEzODV7MkW=
Sk-Hep1 M1TmVmN6fG:2b4jpZ{BCe3OjeR?= NH\LPIEyOCEQvF2= M4myU|I1KGh? M4XjW2ROW09? NVnDPVdCW2Wwc3n0bZpmeyC{ZYPpd5RidnRiY3XscJMhfG9idHjlJIN6fG:2b4jpZ{Bm\m[nY4Sgc4Yhe2:{YX\lcolj MoTWNlEzODV7MkW=
OCUT1 cells harbored PIK3CA (H1047R+/+) MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnToN{DPxE1? Mk[2OUBl NILpfFdFVVOR MkXITWM2OD1yLkG0JO69VQ>? NH\OW4QzOTJ6OUK2Oy=>
K1 cells harbored PIK3CA (E542K+/+) MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnLN{DPxE1? NEfXcHc2KGR? Mn7VSG1UVw>? NFPxOlJKSzVyPUCuOVIh|ryP MWmyNVI5QTJ4Nx?=
FTC133 cells harbored PTEN (allele deletion and R130+) NWizb4JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXObXpCOyEQvF2= NWWwNmZoPSCm MmTkSG1UVw>? NH3M[4xKSzVyPUCuNVgh|ryP NHThVHEzOTJ6OUK2Oy=>
C643 cells harbored HRAS (G13R+/−) MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jublMh|ryP MU[1JIQ> NIHobmVFVVOR M1u3XWlEPTB;MD6yO{DPxE1? M1XRVlIyOjh7Mk[3
Hth7 cells harbored NRAS (Q61R+/−) NFPUNnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU[zJO69VQ>? MnHMOUBl NGnMSZdFVVOR NXLCRo1XUUN3ME20MlUh|ryP MWiyNVI5QTJ4Nx?=
TPC1 cells harbored RET/PTC1 rearrangement MnX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n0eVMh|ryP NEnOdGQ2KGR? MYXEUXNQ NXjZZZV2UUN3ME2wMlU6KM7:TR?= MUWyNVI5QTJ4Nx?=
Hth74 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHziOZU{KM7:TR?= MoW5OUBl M2X5[GROW09? M2jDfGlEPTB;Mj6xPUDPxE1? Mm\BNlEzQDl{Nke=
KAT18 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TiT|Mh|ryP NYK2cm5tPSCm MoTSSG1UVw>? Mm\vTWM2OD12Lk[yJO69VQ>? MV[yNVI5QTJ4Nx?=
SW1736 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zPeVExOCEQvF2= NV3oW2Y6PSCm MmrJSG1UVw>? Mo\RTWM2OD12Nz61OkDPxE1? MofENlEzQDl{Nke=
WRO MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT6eIFWOTByMDFOwG0> MkGwOUBl MlzMSG1UVw>? M4HveGlEPTB-MUCwNEDPxE1? MlzQNlEzQDl{Nke=
TAD2 NVjpeVNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rkdVExODBizszN NFyxXY42KGR? MVHEUXNQ NYXYN2ZMUUN3ME6xNFAxKM7:TR?= MYiyNVI5QTJ4Nx?=
LN229 MUHBdI9xfG:|aYOgRZN{[Xl? MVOwMlUh|ryP NEDqXlU3OCCq MlX3SG1UVw>? MoLYRZVodWWwdIOgZZBweHSxZ3XubYMh\W[oZXP0d{Bw\iCpZX\peIlvcWJ? NXq5cZdzOjJyNUe5NVQ>
T98G NWfXfXVtSXCxcITvd4l{KEG|c3H5 MkjjNE42KM7:TR?= NILMbm43OCCq MlPCSG1UVw>? NHKzbpBCfWevZX70d{BieG:ydH;n[Y5q[yCnZn\lZ5R{KG:oIHfl[ol1cW6rYh?= MnHENlIxPTd7MUS=
HC11 Mn7OSpVv[3Srb36gRZN{[Xl? NWTT[o0{OTBizszN NHjvcoYzPCCq MlnvSG1UVw>? M2TLRmlvcGmkaYTzJO6zNWOjc3XpckBidmRiQVTSVEB{gW62aHXzbZM> NYHaOZJDOjJ2Mk[2NlE>
MOLT-4 M4K0fmN6fG:2b4jpZ{BCe3OjeR?= MkTKNVAh|ryP M1vJXlQ5KGh? NFjIVI9FVVOR Mn61TWM2OD1zLkhihKnPxE1? NELJZlczOjZzNEK0Ny=>
CEM-R MYPDfZRwfG:6aXOgRZN{[Xl? NFu3d|IyOCEQvF2= MVG0PEBp M2e2VWROW09? NHfqb4pKSzVyPUOuN-KBkc7:TR?= MnfzNlI3OTR{NEO=
CEM-S MVLDfZRwfG:6aXOgRZN{[Xl? NIn3b5kyOCEQvF2= NWCyfpZbPDhiaB?= NWHLVpFXTE2VTx?= MYTJR|UxRTVwMfMAje69VQ>? NXXFTpJCOjJ4MUSyOFM>
MOLT-4 NFHKc2FHfW6ldHnvckBCe3OjeR?= MoXTNVAh|ryP MYmyOEBp NI[yTYNFVVOR MYDCcI9kc3NiY3XscJMhcW5idHjlJGcxN0dzIIDoZZNmKG:oIITo[UBk\WyuIHP5Z4xm MWSyNlYyPDJ2Mx?=
MOLT-4 MnG5SpVv[3Srb36gRZN{[Xl? M4TxTVTjiIoQvF2= Mn;NOEBp Mm\1SG1UVw>? MX\JcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFM1GvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> NYr5TngxOjJ4MUSyOFM>
CEM-R MUjGeY5kfGmxbjDBd5NigQ>? NGXiXVE16oDLzszN M4TOOlQhcA>? M{j1cmROW09? M4Dxemlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFO0RU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? NE\RWGIzOjZzNEK0Ny=>
CEM-S NG[4d2hHfW6ldHnvckBCe3OjeR?= NGHDUpc16oDLzszN NXLabGpEPCCq M1fXZmROW09? NHWwb2tKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDOWEwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? Ml\nNlI3OTR{NEO=
HepG2 cell NY\6fnB4U2mwYYPlJGF{e2G7 NGPhbFgzOCEQvF2= MlK1NlQhcA>? M3\5WGROW09? NEXsPIFFd3ewcnXneYxifGW|IITo[UBxcG:|cHjvdplt[XSrb36gc4YhSUuW NILMR4IzOzd7N{OxPS=>
HepG2 cell NWT4ZoRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELoOJg{OCEQvF2= MUeyOEBp MUHEUXNQ NHXCXHNKdmirYnn0d{Bk\WyuIHfyc5d1cA>? NUPDUoFwOjN5OUezNVk>
HepG2 cell NVvWTZNESXCxcITvd4l{KEG|c3H5 MoT4NlAh|ryP NWHYPVV6OjRiaB?= NXXkXFdCTE2VTx?= M3uwVWlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? MXuyN|c6PzNzOR?=
GEO MkDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[1NFAhdk1? MYC3NkBp MX3EUXNQ M2\Wb2lvcGmkaYTzJINmdGxiZ4Lve5Rp NGWzdGQzPDV6MUKzNS=>
CNE-1 M2Swe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3De2lpOTBizszN NWe4[VRvQTZiaB?= M2TUSmROW09? NHjjWppKSzVyPUKuPVYh|ryP MkSwNlU{OzZ7MkW=
CNE-2 MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvuNVAh|ryP MmTTPVYhcA>? Mlz4SG1UVw>? M1T2TmlEPTB;ND61N{DPxE1? Mm\YNlU{OzZ7MkW=
HONE-1 NH\ndldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DXcFExKM7:TR?= NHjWbJU6PiCq MYHEUXNQ NILIPJJKSzVyPUOuN|ch|ryP MlK1NlU{OzZ7MkW=
SUNE-1 NFXBVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWT5fGs{OTBizszN MUG5OkBp MoTRSG1UVw>? MXrJR|UxRTBwNUKg{txO NHjmU2ozPTN|NkmyOS=>
CNE-2 NWnOc5NGTnWwY4Tpc44hSXO|YYm= NGDBVVEyOCEQvF2= NH:5eGo1QCCq M1PmVmROW09? NUnSb4RjUW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCJMR?= M1PRS|I2OzN4OUK1
HONE-1 MUHGeY5kfGmxbjDBd5NigQ>? M2joWVExKM7:TR?= MXu0PEBp NVrISGEyTE2VTx?= M1rld2lv\HWlZYOgZ4VtdCCleXPs[UBienKnc4SgZZQhTzF? NVmyPZN[OjV|M{[5NlU>
NEC8 NWL2TY9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzqTWM2OD1yLkC5OlUyKM7:TR?= NIG5eZFUSU6JRWK=
P12-ICHIKAWA MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjZbYhKSzVyPUCuNVE3OiEQvF2= Mo\aV2FPT0WU
MDA-MB-175-VII MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrKfVhKSzVyPUCuNVM4OzhizszN NUK5cmhqW0GQR1XS
AsPC-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\FRpozUUN3ME2wMlIzOTJ{IN88US=> M1nCWXNCVkeHUh?=
T47D MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3r6SmlEPTB;MD6yPFI2KM7:TR?= MlviV2FPT0WU
HH Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwM{CyPFMh|ryP MYrTRW5ITVJ?
MOLT-16 M4PrTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwM{CzNkDPxE1? NUO1SplIW0GQR1XS
ES5 NYnxcYplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwM{S0OVUh|ryP M{m3eHNCVkeHUh?=
RS4-11 NVXF[IJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHkWXhKSzVyPUCuN|Q3OSEQvF2= MWfTRW5ITVJ?
KARPAS-45 M4LpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwM{ezNlEh|ryP NYXzUWw4W0GQR1XS
NCI-H720 M2nvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf0UYhKSzVyPUCuN|c3PzlizszN NILxXmNUSU6JRWK=
H9 NXu0O2ptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwM{i4PFMh|ryP NEf5OWpUSU6JRWK=
EFM-19 NVj5cZBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mly1TWM2OD1yLkS0NFEh|ryP NH;xR5dUSU6JRWK=
SBC-1 NVLYcWdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L6V2lEPTB;MD60OFA{PSEQvF2= M3j2OXNCVkeHUh?=
A4-Fuk NVfrNY53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInQVJNKSzVyPUCuOFY5PjhizszN NX;GUVNyW0GQR1XS
NCI-H1563 Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HjU2lEPTB;MD60PFE5QSEQvF2= NG[xUVhUSU6JRWK=
HCC1419 Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHLTWM2OD1yLkS4PFkzKM7:TR?= M{PldHNCVkeHUh?=
H-EMC-SS M4P0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNEm5N|kh|ryP MV;TRW5ITVJ?
BHT-101 NV3CO2JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;FcY1KSzVyPUCuOVI6PjFizszN MnvGV2FPT0WU
IGROV-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwNUWyOFkh|ryP MmTEV2FPT0WU
HGC-27 M4LuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjTdW1KSzVyPUCuOVY4QDNizszN MVXTRW5ITVJ?
MDA-MB-361 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVeyTY11UUN3ME2wMlU4PzZzIN88US=> NU[3TlFtW0GQR1XS
KE-37 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\ROFdKSzVyPUCuOVgzPiEQvF2= NEWzXXNUSU6JRWK=
HCC70 NXvPb4FxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTtd|A5UUN3ME2wMlU6QDJ5IN88US=> NIPTZVFUSU6JRWK=
LNCaP-Clone-FGC NU[3e4JiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7NTWM2OD1yLk[xNFQ5KM7:TR?= MWnTRW5ITVJ?
HAL-01 MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rUc2lEPTB;MD62NlE{KM7:TR?= NYD4OZREW0GQR1XS
HT NIrDTGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNkOyN|kh|ryP M1i4cnNCVkeHUh?=
MDA-MB-415 NXTq[W57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL6R4E{UUN3ME2wMlY{PjJ4IN88US=> NIHTTW5USU6JRWK=
NOS-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjpNWtKSzVyPUCuOlM4OjNizszN NHXkN|JUSU6JRWK=
DU-145 M2K1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPUNmRKSzVyPUCuOlQ4PDVizszN MmP2V2FPT0WU
OCUB-M Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwN{C5OlYh|ryP MlXLV2FPT0WU
VA-ES-BJ MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHqySZBKSzVyPUCuO|MxOjVizszN MUjTRW5ITVJ?
J-RT3-T3-5 NWLheXltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHqfncxUUN3ME2wMlc1PDB|IN88US=> MmLHV2FPT0WU
MOLT-4 NHXvT5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwOEC1PFIh|ryP NFPKV|hUSU6JRWK=
NB7 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVK2UWhXUUN3ME2wMlgzPDFzIN88US=> NHXwT2pUSU6JRWK=
L-363 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELqeoFKSzVyPUCuPFM1PDJizszN MlLLV2FPT0WU
NKM-1 MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXBTWM2OD1yLki2NlU{KM7:TR?= NEjU[|RUSU6JRWK=
HOP-92 M4LlXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwOEeyNlMh|ryP NFHGVo9USU6JRWK=
OAW-42 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEC5SpRKSzVyPUCuPFg4OiEQvF2= MX;TRW5ITVJ?
HuO9 NYHR[4ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n0bmlEPTB;MD65Nlc2OSEQvF2= MUHTRW5ITVJ?
MFE-280 NYfROJNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwOU[0OlUh|ryP NH76bWxUSU6JRWK=
EM-2 M3zWWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv4S|ZKSzVyPUCuPVc6OzlizszN MYHTRW5ITVJ?
NCI-H520 NIXDeXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3ncIZKSzVyPUCuPVg2QTJizszN MnvvV2FPT0WU
LB2241-RCC NWPrWnNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfQe25KSzVyPUCuPVk4OzRizszN MWLTRW5ITVJ?
SK-NEP-1 M4\jdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFwMUS0PFUh|ryP MnLEV2FPT0WU
LXF-289 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv0fFVKSzVyPUGuNVcyPTZizszN MVnTRW5ITVJ?
EPLC-272H Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTzPG1KSzVyPUGuNVczPTZizszN NWWxOpBjW0GQR1XS
COLO-684 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrZUodKSzVyPUGuNlM4OjVizszN NHvTcXdUSU6JRWK=
ES1 NWDVdYptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTFwMkSwOlUh|ryP NYXNfZF{W0GQR1XS
DOHH-2 MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r2ZWlEPTB;MT6yPFIxOyEQvF2= M2rtRnNCVkeHUh?=
CTB-1 MkT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULidoh{UUN3ME2xMlI5QTlizszN NUPGR2lzW0GQR1XS
G-401 NUPxbGY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDDTWM2OD1zLkK5O|k2KM7:TR?= MlPuV2FPT0WU
LoVo MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH75VWRKSzVyPUGuN|I2OzRizszN M4jsbXNCVkeHUh?=
Ramos-2G6-4C10 NYex[ooxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXlSFI1UUN3ME2xMlM{PzBzIN88US=> NIC0VHRUSU6JRWK=
MFM-223 M37Ddmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFwM{S0OlEh|ryP NWLYUJc6W0GQR1XS
PA-1 MlLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL2TWM2OD1zLkO1NlY2KM7:TR?= M4DkVHNCVkeHUh?=
697 NEnJWYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojoTWM2OD1zLkO3OlE3KM7:TR?= NF;FXHVUSU6JRWK=
QIMR-WIL Mn;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFwNEmxNVYh|ryP MlzVV2FPT0WU
HOS MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnaR2hZUUN3ME2xMlQ6PTV6IN88US=> NFjuemxUSU6JRWK=
DMS-273 M2HDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\CTWM2OD1zLkWxPVU6KM7:TR?= MXrTRW5ITVJ?
ME-180 NUHhd3AxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\3TWM2OD1zLkW2PFkyKM7:TR?= MXPTRW5ITVJ?
HCC2218 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPp[VlKSzVyPUGuOlgzOjVizszN MoDsV2FPT0WU
CAL-54 MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLvTWM2OD1zLkexNlQzKM7:TR?= M3O2PHNCVkeHUh?=
OMC-1 NGrFR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LR[WlEPTB;MT63OFY4PyEQvF2= MoOzV2FPT0WU
COR-L105 NV35OHBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnvRlNWUUN3ME2xMlc6PzN5IN88US=> NWfre3pLW0GQR1XS
BV-173 M{nYNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWwWYx2UUN3ME2xMlgyODd2IN88US=> M3\MWXNCVkeHUh?=
RKO MoXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HZTGlEPTB;MT64O|ExOSEQvF2= NV7SXGp[W0GQR1XS
SNU-387 MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP3OJlKSzVyPUGuPFg1ODZizszN NEnUNI1USU6JRWK=
SW1088 NVG2WGhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1q0OmlEPTB;MT65OFYxPiEQvF2= M2TIPHNCVkeHUh?=
Hs-578-T Mon6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;BTWM2OD1{LkGxOFM{KM7:TR?= MkXXV2FPT0WU
OC-314 NFTZVZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DDRmlEPTB;Mj6xOVA5PiEQvF2= MonRV2FPT0WU
RMG-I MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJwMU[zPVgh|ryP M1Pre3NCVkeHUh?=
NCI-H1395 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTQcY5SUUN3ME2yMlE5ODlzIN88US=> M4HjWnNCVkeHUh?=
GAMG NGjCdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fR[WlEPTB;Mj6yN|g1PSEQvF2= MYrTRW5ITVJ?
LB1047-RCC NX\WVXY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj4TWM2OD1{LkK0N|E4KM7:TR?= Ml;pV2FPT0WU
MN-60 NVHpVXlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fYZWlEPTB;Mj6yPVkzOyEQvF2= NH3TNW9USU6JRWK=
OAW-28 NWjsdmNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHHb4RDUUN3ME2yMlI6QTVzIN88US=> MYjTRW5ITVJ?
NCI-H2228 M4SxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XiOWlEPTB;Mj6zNVU2OiEQvF2= MWfTRW5ITVJ?
ABC-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\mSJBpUUN3ME2yMlM{OjV|IN88US=> NIjxOZlUSU6JRWK=
LS-513 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDETWM2OD1{LkOzOFg1KM7:TR?= Mn2xV2FPT0WU
KS-1 NFLQPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX0TWM2OD1{LkO4NVkyKM7:TR?= MXfTRW5ITVJ?
NB69 M3Gwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn1TWM2OD1{LkO4PVg{KM7:TR?= M1myPHNCVkeHUh?=
VM-CUB-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojITWM2OD1{LkO5NFg{KM7:TR?= M1\pT3NCVkeHUh?=
D-423MG M2KzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJwNEGwOFQh|ryP M{WwV3NCVkeHUh?=
EW-18 MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXZXI9KSzVyPUKuOFE6OzlizszN MVXTRW5ITVJ?
YH-13 NUDtUFFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TaR2lEPTB;Mj60OlE2OyEQvF2= NVXZS4FtW0GQR1XS
T-24 M3;kT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vhd2lEPTB;Mj60O|g5OSEQvF2= NEW3NYtUSU6JRWK=
ES8 MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJwNEmyPFch|ryP NFG2XHRUSU6JRWK=
ES3 NYOwUnpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjTc2JKSzVyPUKuOFk4PTlizszN NVLi[JZYW0GQR1XS
RXF393 NEXUTpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJwNkC0PFch|ryP M1;3Z3NCVkeHUh?=
RPMI-8226 M{PsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7hTWM2OD1{Lk[yPVU{KM7:TR?= NHnzUJFUSU6JRWK=
AGS MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7hTWM2OD1{LkeyNVM4KM7:TR?= NYnUU|RvW0GQR1XS
HCC1395 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Dqb2lEPTB;Mj63OVE5PyEQvF2= NGm0cXVUSU6JRWK=
MV-4-11 M4rQb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJwN{WyOlYh|ryP NIPRdZZUSU6JRWK=
A204 Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJwOEO4O|Ih|ryP M172enNCVkeHUh?=
MCF7 M4PQeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj5XpdMUUN3ME2yMlg3OTF5IN88US=> NGXJV21USU6JRWK=
SNU-423 Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlL4TWM2OD1{Lki5NlQzKM7:TR?= NVjKbpB{W0GQR1XS
NCI-H1048 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXYbWtKSzVyPUKuPVY5PjVizszN MofhV2FPT0WU
GR-ST MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTNwMES2NVEh|ryP M2[ycHNCVkeHUh?=
EoL-1- MonlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTNwMEewOVgh|ryP MYHTRW5ITVJ?
HuH-7 M1fwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTNwMEm0OlQh|ryP MVzTRW5ITVJ?
OS-RC-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITHTZRKSzVyPUOuNVEyQSEQvF2= NYfvfW9iW0GQR1XS
EW-3 NE[zWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTNwMUm1Nlkh|ryP M1S3[HNCVkeHUh?=
NCI-H747 NWOxUYd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;xTWM2OD1|LkKwOlk1KM7:TR?= MYPTRW5ITVJ?
EW-16 MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHVenF4UUN3ME2zMlIyQDd7IN88US=> NYD4PWt3W0GQR1XS
DOK M4HUeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzHTldKSzVyPUOuNlI5PTlizszN MXjTRW5ITVJ?
HCC2157 NE[yUndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFryfHNKSzVyPUOuN|gyPzlizszN NXrnWlFOW0GQR1XS
OVCAR-3 NWC3Nod2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPERYFsUUN3ME2zMlQxPzh4IN88US=> MkLyV2FPT0WU
NCI-H1623 MnLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\lTWM2OD1|LkSxNlI1KM7:TR?= MULTRW5ITVJ?
H4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7KfFlKSzVyPUOuOFU3OjZizszN NWXxVHl1W0GQR1XS
SW1710 M4SzWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jmRWlEPTB;Mz60OlY4QCEQvF2= NV73b443W0GQR1XS
RT-112 M1HRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWewUWpIUUN3ME2zMlUzOzh6IN88US=> M{W5cXNCVkeHUh?=
DMS-114 NGC0cnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFew[|ZKSzVyPUOuOlIzPzhizszN Ml3HV2FPT0WU
AN3-CA M4HVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G0emlEPTB;Mz62NlQ2PiEQvF2= M{n6e3NCVkeHUh?=
KNS-62 NXfDdW5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWmxfmNqUUN3ME2zMlY{OzN6IN88US=> MXrTRW5ITVJ?
SJRH30 NEDDNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTNwNkmxNlIh|ryP MoTFV2FPT0WU
G-402 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX0VJlHUUN3ME2zMlcxPzFzIN88US=> NWXQSYhEW0GQR1XS
MHH-PREB-1 NESzVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPy[W16UUN3ME2zMlczODN6IN88US=> M1fI[HNCVkeHUh?=
P30-OHK M3nmb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17TW2lEPTB;Mz64NFk4PiEQvF2= M1T1bXNCVkeHUh?=
RVH-421 NEjlcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTNwOEG3PFgh|ryP MV;TRW5ITVJ?
LU-134-A M{TXXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vFU2lEPTB;Mz64PFQzQCEQvF2= NUL1NGZkW0GQR1XS
ECC10 NULT[nNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXJTWM2OD1|LkmzOlIzKM7:TR?= M13KUXNCVkeHUh?=
TGW NWrJVINUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLPSHpKSzVyPUSuNFI{ODVizszN MXTTRW5ITVJ?
MLMA NXrBRo4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrUcoVKSzVyPUSuNFI6PjZizszN MVTTRW5ITVJ?
SCC-25 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPwfVJqUUN3ME20MlA3PTZ4IN88US=> NYT2UoQ3W0GQR1XS
TYK-nu MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTRwMEm1N|Qh|ryP MULTRW5ITVJ?
LAMA-84 Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4SxU2lEPTB;ND6xOFE6OSEQvF2= M4TOT3NCVkeHUh?=
Calu-3 NHu0WmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{ThWmlEPTB;ND6yOFQyPiEQvF2= M{PW[XNCVkeHUh?=
NCI-H460 NW\hNlVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfMPHpKSzVyPUSuNlY1PDNizszN M1XD[XNCVkeHUh?=
EGI-1 NIL0XmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\lWG5SUUN3ME20MlM4Pzd6IN88US=> MVLTRW5ITVJ?
NCI-H292 MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojFTWM2OD12LkO4NVQ3KM7:TR?= NE\ZdIVUSU6JRWK=
HCE-T NHrTNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrDTWM2OD12LkSxOVc6KM7:TR?= MkLXV2FPT0WU
EW-11 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTZXYFKSzVyPUSuOFE5OzhizszN MUXTRW5ITVJ?
ATN-1 M{PUWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLoW5diUUN3ME20MlQ1OzB2IN88US=> NFq2S3NUSU6JRWK=
NB5 NH7VOnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW3eY9KSzVyPUSuOVM3QTdizszN NHjtb3JUSU6JRWK=
KLE NG\LNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHOTWM2OD12LkewNVk5KM7:TR?= NFnYWY5USU6JRWK=
CAL-39 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfJUm9sUUN3ME20MlczOTR4IN88US=> M4TXTXNCVkeHUh?=
TI-73 NX[4U2NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrDfG1KSzVyPUSuPFA3ODlizszN M33RNHNCVkeHUh?=
HO-1-N-1 NHrBfWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCzTWM2OD12Lkm0NkDPxE1? MoX5V2FPT0WU
786-0 NILMVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XsdWlEPTB;ND65OFY4OyEQvF2= NVvmRmtNW0GQR1XS
SK-N-DZ M4q4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi0R4dGUUN3ME20Mlk3OTR{IN88US=> NXH2SYZ2W0GQR1XS
NCI-H446 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnrTWM2OD13LkKwNFA6KM7:TR?= MkjRV2FPT0WU
ETK-1 M1rvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\UWphKSzVyPUWuNlEyPjVizszN Mon0V2FPT0WU
BT-20 NWHQWWNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkSxTWM2OD13LkKxN|U{KM7:TR?= NHnoVY9USU6JRWK=
MEL-HO NX:1bItFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnZZWZKSzVyPUWuN|c{OzZizszN MYXTRW5ITVJ?
CAL-27 M2TK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1i5WWlEPTB;NT60OlM{QSEQvF2= M3Oze3NCVkeHUh?=
SW872 NXnqNYFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vkN2lEPTB;NT61PVQzQCEQvF2= M4nN[nNCVkeHUh?=
RPMI-2650 NIq3XpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3OyUGlEPTB;NT62OlE6QSEQvF2= MnLRV2FPT0WU
PFSK-1 NV3xUG9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTVwN{K3N|Ih|ryP Mo\WV2FPT0WU
SF295 MmC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M171R2lEPTB;NT64NFY{OyEQvF2= M4XQdXNCVkeHUh?=
Becker MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\rXmlEPTB;NT64OlQ4OiEQvF2= MUXTRW5ITVJ?
Saos-2 NGDlV4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTVwOE[1N{DPxE1? NFS4NGdUSU6JRWK=
SK-OV-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPVOllFUUN3ME21Mlk6QDF4IN88US=> MXXTRW5ITVJ?
VMRC-RCZ MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGmxe49KSzVyPU[uNFg4PzNizszN NUn1UYsxW0GQR1XS
EW-22 NV3uUIdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXmTWM2OD14LkG5OlQ6KM7:TR?= MX;TRW5ITVJ?
BT-474 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrTTWM2OD14LkKzN{DPxE1? NHvacm9USU6JRWK=
BFTC-909 Mm\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XneWlEPTB;Nj6zNFM1PSEQvF2= M1PYNnNCVkeHUh?=
NB12 M33QNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP4ZWM6UUN3ME22MlM6ODdzIN88US=> NF;IU|ZUSU6JRWK=
D-263MG NX\2SWJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPrWI56UUN3ME22MlQ2OTZ7IN88US=> NVroUWkxW0GQR1XS
SNB75 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4GyXGlEPTB;Nj62NFE1OyEQvF2= MVTTRW5ITVJ?
A704 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\STWM2OD14Lk[zNFYh|ryP MoLjV2FPT0WU
NCI-H1693 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTZwNkO2NFQh|ryP MUTTRW5ITVJ?
LN-405 M1vxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HE[mlEPTB;Nj63PVY4OiEQvF2= MkX0V2FPT0WU
CHL-1 NIrMT5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3QeJJKSzVyPU[uPFAxPzlizszN MWrTRW5ITVJ?
A498 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33PUmlEPTB;Nj64NVk3OSEQvF2= NG\OZ|NUSU6JRWK=
TE-12 M1jNSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTZwOEO4NVch|ryP MlnmV2FPT0WU
TE-6 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD6TlJUUUN3ME22Mlk{ODN6IN88US=> NWi0cFhzW0GQR1XS
AU565 NFzXdpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\DWI5FUUN3ME22Mlk3QTV5IN88US=> MYHTRW5ITVJ?
RD NF\KdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTZwOUiyPFQh|ryP M2\x[XNCVkeHUh?=
SW1463 NYnp[YVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\oNmlEPTB;Nz6xNVE3QCEQvF2= MonkV2FPT0WU
LU-99A NWHIcnNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTdwMUSzNlIh|ryP NHr0fG5USU6JRWK=
NCI-H28 M{[2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTdwMkmyOEDPxE1? M2rpO3NCVkeHUh?=
MC-IXC MmXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHyTWM2OD15LkS4OVc3KM7:TR?= NGe0b45USU6JRWK=
GP5d NHPocIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HWTGlEPTB;Nz60PFc3PCEQvF2= Mln4V2FPT0WU
GB-1 NIHQU2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTaZWZKSzVyPUeuOVQ5ODRizszN NFSyW2dUSU6JRWK=
CAL-33 NGfONJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;ITWM2OD15Lk[2NlM{KM7:TR?= MVXTRW5ITVJ?
MSTO-211H MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnReXNpUUN3ME23MlY4OzN4IN88US=> MlLOV2FPT0WU
TE-5 NUjJXJN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljXTWM2OD15Lke5N|M1KM7:TR?= NXiyUJJJW0GQR1XS
D-566MG NFnhOZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRThwMES0Nlkh|ryP NYPmTmJlW0GQR1XS
JVM-3 NVjINllqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;DfGlEPTB;OD6xOVI3QCEQvF2= MVXTRW5ITVJ?
T98G MlzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jid2lEPTB;OD6xPFA3PyEQvF2= NGriXFJUSU6JRWK=
HCC1954 M33VTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRThwNEWxNFQh|ryP M2D6bHNCVkeHUh?=
SF126 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvWelZKSzVyPUiuOFU6OzZizszN NHHEfmNUSU6JRWK=
LB996-RCC NITaR2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLBTWM2OD16LkWzNlU4KM7:TR?= NEXUblBUSU6JRWK=
SKG-IIIa NXnr[3UxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDrTWM2OD16Lk[zNFY6KM7:TR?= MlT6V2FPT0WU
NCI-SNU-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Dle2lEPTB;OD62OFY1OyEQvF2= M3fBNnNCVkeHUh?=
LB771-HNC MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HvdWlEPTB;OD62OFY6PiEQvF2= MV3TRW5ITVJ?
SCC-4 NHnlSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfqe4oyUUN3ME24MlY5OjF7IN88US=> NV\zPZd{W0GQR1XS
CAMA-1 M33Ie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHlT2tKSzVyPUiuO|cyPDZizszN NVj1SYc3W0GQR1XS
D-502MG MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRThwN{i2Nlkh|ryP MVHTRW5ITVJ?
ESS-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkToTWM2OD16Lki4O|A1KM7:TR?= M3PQNnNCVkeHUh?=
HEC-1 NUe2ZVBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRThwOEm4OlYh|ryP MXXTRW5ITVJ?
NB10 NFn3WWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fESGlEPTB;OT6wNlIzPCEQvF2= NV7aZmVqW0GQR1XS
8505C NIezS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYT2Z5RsUUN3ME25MlA1OjN{IN88US=> M{nyTnNCVkeHUh?=
EFO-27 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3JTWM2OD17LkG2OFEzKM7:TR?= M4\UfnNCVkeHUh?=
HN M{jCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLhTWM2OD17LkG2OlI5KM7:TR?= NGHyS5hUSU6JRWK=
DSH1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfteY84UUN3ME25MlIxQDdizszN NYXhOWc6W0GQR1XS
NBsusSR NWja[4tuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTlwMke0NFIh|ryP M1raRXNCVkeHUh?=
LS-123 MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLCUFM6UUN3ME25MlMyPzZzIN88US=> NEPYVnJUSU6JRWK=
SHP-77 M{L0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7OTWM2OD17LkO5PVM2KM7:TR?= NF6zUXZUSU6JRWK=
ACN NGrZTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M376T2lEPTB;OT61N|I4PyEQvF2= NFrJXlNUSU6JRWK=
U251 M{fXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTlwNkW1OFQh|ryP MlfnV2FPT0WU
A431 NH;VNGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy5U5dXUUN3ME25MlgxOjN6IN88US=> NGH3NlhUSU6JRWK=
5637 MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7WPWNKSzVyPUmuPFQ6QDRizszN Mor3V2FPT0WU
MDA-MB-157 M2jxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnYTWM2OD17LkmyPFc5KM7:TR?= MkLRV2FPT0WU
A101D Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTlwOUm5O|Qh|ryP NF7NWmlUSU6JRWK=
YKG-1 NGXKSG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2q1OmlEPTB;MUCuNlAxPiEQvF2= MlLXV2FPT0WU
LAN-6 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTRTWM2OD1zMD6yNVY1KM7:TR?= Ml3pV2FPT0WU
OVCAR-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFyLkK0N|Mh|ryP NHeyNVJUSU6JRWK=
A549 MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j2PGlEPTB;MUCuN|k4OyEQvF2= M{XHT3NCVkeHUh?=
no-11 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTFyLkSzOVMh|ryP NFntSopUSU6JRWK=
SF539 MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlriTWM2OD1zMD65NFQyKM7:TR?= NVTXd4tOW0GQR1XS
A388 M4q1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrITWM2OD1zMT6zPFk4KM7:TR?= NGTycpJUSU6JRWK=
DEL M2nhO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFzLkSyOEDPxE1? NVHNdWpvW0GQR1XS
SW954 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTFzLkS2Olgh|ryP MYrTRW5ITVJ?
TK10 NGPPd2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHWOnZ7UUN3ME2xNU42OjdzIN88US=> MorLV2FPT0WU
SW756 M4fyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzU[phKSzVyPUGxMlUzQTRizszN MmrZV2FPT0WU
PC-3 Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPGSFVqUUN3ME2xNU42PzZ2IN88US=> NYm1[ZcyW0GQR1XS
ONS-76 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XkSWlEPTB;MUGuOlM3KM7:TR?= MYLTRW5ITVJ?
A427 M4HHdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFzLkewPVMh|ryP M1X3UnNCVkeHUh?=
MEG-01 M4\K[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFzLke1NFkh|ryP NIiyemdUSU6JRWK=
BB30-HNC MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFzLke5PFIh|ryP MYTTRW5ITVJ?
NCI-H1299 M17UbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTFzLkiwPVMh|ryP MW\TRW5ITVJ?
GCT MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n1W2lEPTB;MUGuPFIzQCEQvF2= NULW[GN7W0GQR1XS
D-247MG MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrPVpp5UUN3ME2xNU46PjZ|IN88US=> MVzTRW5ITVJ?
CFPAC-1 NEXTWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jnU2lEPTB;MUGuPVc5OiEQvF2= M37T[nNCVkeHUh?=
EKVX M1;0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTF{LkCzNVMh|ryP NULWbZV7W0GQR1XS
CAL-51 NWnDUGNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjpbIZKSzVyPUGyMlA4OTZizszN NFLHdoJUSU6JRWK=
BB49-HNC NYXSRm95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnKW2JxUUN3ME2xNk4yOTd5IN88US=> M1vDWnNCVkeHUh?=
RPMI-7951 NHzBOXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjxcYxKSzVyPUGyMlE5PTRizszN MYTTRW5ITVJ?
RH-1 M3[3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu0TWM2OD1zMj6yNVg1KM7:TR?= NFTHbZpUSU6JRWK=
BCPAP M4Tx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjMdnZKSzVyPUGyMlQ4PDlizszN M1jV[HNCVkeHUh?=
GCIY NWLMZmlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTF{LkWyNFkh|ryP NXfoPGtPW0GQR1XS
KNS-81-FD M{e3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjmTWM2OD1zMj61PFY6KM7:TR?= MlTOV2FPT0WU
KYSE-140 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\HPWlEPTB;MUKuPFU6PSEQvF2= MU\TRW5ITVJ?
Ca-Ski NUDtWZE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDDdVFKSzVyPUGyMlkxPDFizszN NV3nU3E4W0GQR1XS
TGBC1TKB MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC5d|hKSzVyPUGyMlkyOTVizszN MX;TRW5ITVJ?
HCC1187 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfq[YdKSzVyPUGzMlE6OTJizszN NIjn[mhUSU6JRWK=
SJSA-1 NYTSXm05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPUTWM2OD1zMz6yN|I4KM7:TR?= MnLBV2FPT0WU
CTV-1 NH\RS5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTF|LkO0OUDPxE1? NUTwUmRIW0GQR1XS
WM-115 NWTDN|B5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLYWYFlUUN3ME2xN{43PDh|IN88US=> MXfTRW5ITVJ?
CHP-212 M3H4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTF|Lkm3N|kh|ryP MmC0V2FPT0WU
SCC-15 M{KyNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF|Lkm3O|Uh|ryP MYPTRW5ITVJ?
BPH-1 MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Tqe2lEPTB;MUSuNVY3PCEQvF2= MnOxV2FPT0WU
SW780 NXTxRmZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET3cYJKSzVyPUG0MlUxOjVizszN M1ro[3NCVkeHUh?=
NCI-H2291 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPGTWM2OD1zND61PFc5KM7:TR?= NYjmOWFbW0GQR1XS
JEG-3 NYnNVVRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnPTWM2OD1zND62N|I3KM7:TR?= MYDTRW5ITVJ?
CAL-120 M3rMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPqTVJKSzVyPUG0MlcxOjdizszN NYjXd|B7W0GQR1XS
NCI-H23 NYXTTJZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nZfWlEPTB;MUSuO|k6PyEQvF2= NFjtSIFUSU6JRWK=
MS-1 Mn35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7PTWM2OD1zND65OlEyKM7:TR?= M2T3fXNCVkeHUh?=
PC-14 M4j4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTF2Lkm2OVQh|ryP MYHTRW5ITVJ?
D-283MED MmPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG5SWJKSzVyPUG1MlAyOTFizszN NX\Bd4FzW0GQR1XS
OE19 NXO2VnVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;2NVJPUUN3ME2xOU4yPTRzIN88US=> MkTXV2FPT0WU
CAS-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPWZnVKSzVyPUG1MlQyQDRizszN NU\VV4FjW0GQR1XS
NCI-H727 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LiUmlEPTB;MUWuOFIzOSEQvF2= MVTTRW5ITVJ?
SiHa MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLpSZFFUUN3ME2xOU44PTl2IN88US=> M2q3d3NCVkeHUh?=
BFTC-905 NFLweoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHxTWM2OD1zNT63Olk1KM7:TR?= NF;YVXhUSU6JRWK=
MDA-MB-453 NEHB[|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC2T2R7UUN3ME2xOk4yPjR{IN88US=> M{LJPHNCVkeHUh?=
HuP-T3 MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXWSo5KSzVyPUG2MlY{PzNizszN NHrDN3lUSU6JRWK=
SK-LU-1 M{KyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\uOWlEPTB;MU[uOlk2PiEQvF2= M3vXN3NCVkeHUh?=
Detroit562 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\F[4twUUN3ME2xOk44OzF6IN88US=> M4TPZ3NCVkeHUh?=
HCC1569 NIjsR2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W0VmlEPTB;MU[uPFM{PyEQvF2= MULTRW5ITVJ?
SK-MES-1 M{jWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF4Lki0NVkh|ryP NWTrbGltW0GQR1XS
BB65-RCC NIrWUFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXxTmlGUUN3ME2xO{4xPDd7IN88US=> MUfTRW5ITVJ?
LOXIMVI NH7nOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jue2lEPTB;MUeuNFcxPyEQvF2= MoL2V2FPT0WU
SW1783 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjweohTUUN3ME2xO{4yOjhizszN NF;Cd2tUSU6JRWK=
NH-12 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LVXWlEPTB;MUeuN|MxOyEQvF2= M{XhNXNCVkeHUh?=
UACC-257 MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnNNY1nUUN3ME2xO{42PTF{IN88US=> M1n5VnNCVkeHUh?=
KOSC-2 M2G2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHoTWM2OD1zNz62O|U4KM7:TR?= M3zRc3NCVkeHUh?=
KG-1 NE\lW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTF5Lk[5N|ch|ryP NUC5W29KW0GQR1XS
M059J NV;NVGJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTF5LkewN{DPxE1? NYTBN3JMW0GQR1XS
MHH-NB-11 M173b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Py[WlEPTB;MUeuPVY4OyEQvF2= MoTpV2FPT0WU
EW-1 M4j6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfXdIJKSzVyPUG4MlE{QDJizszN MUDTRW5ITVJ?
CAL-85-1 MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TDbmlEPTB;MUiuNlM2PyEQvF2= M2rCVHNCVkeHUh?=
639-V MkLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PRSGlEPTB;MUiuN|M2PCEQvF2= NX7WTlhVW0GQR1XS
C32 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF6LkS3Nlch|ryP MWfTRW5ITVJ?
KM-H2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDLOpVKSzVyPUG4MlUzOzJizszN MkL6V2FPT0WU
A253 MlrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTF6LkeyPFYh|ryP MlnJV2FPT0WU
NCI-N87 NYDD[pRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF6LkmwNFgh|ryP MkDuV2FPT0WU
8-MG-BA NGryc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX2ySYhXUUN3ME2xPU4xPjR4IN88US=> NYLXTotDW0GQR1XS
GI-ME-N MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHTSmxKSzVyPUG5MlE2PDZizszN MUTTRW5ITVJ?
8305C MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jtd2lEPTB;MUmuNlI5PiEQvF2= NHTqbYVUSU6JRWK=
TE-8 NWjGeXFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS3N4VMUUN3ME2xPU4{ODJ2IN88US=> NX7yPJV6W0GQR1XS
KYSE-270 NWTCfoJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTJyLkCyNVch|ryP NVG5U3dFW0GQR1XS
HL-60 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPjUJQ4UUN3ME2yNE4xQTRzIN88US=> NFXtR4NUSU6JRWK=
Mo-T NHW4bopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHmTWM2OD1{MD6xOlY2KM7:TR?= MnHnV2FPT0WU
NCI-H1355 MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqwTWM2OD1{MD6zN|c1KM7:TR?= MVzTRW5ITVJ?
HT-1080 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17hOWlEPTB;MkCuOVQ6PyEQvF2= NWTmcXlCW0GQR1XS
MIA-PaCa-2 M{XwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJyLk[4PFMh|ryP NHm5fFBUSU6JRWK=
NCI-H441 NGe4TnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJyLkezO|kh|ryP NXXveJNQW0GQR1XS
LCLC-97TM1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn4WGtKSzVyPUKwMlgyOzRizszN MkLLV2FPT0WU
HT-3 M1jadGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;FTWM2OD1{MT61OlMyKM7:TR?= M3zRVXNCVkeHUh?=
22RV1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHDTWM2OD1{MT61Olg2KM7:TR?= MWjTRW5ITVJ?
LK-2 NH7uOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLRTWM2OD1{MT61PVU{KM7:TR?= NVHtV|Q5W0GQR1XS
CW-2 NXGyOVFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTJzLk[wOlkh|ryP NXPx[pByW0GQR1XS
KYSE-510 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW4ZWxKSzVyPUKxMlYxQTVizszN MmOzV2FPT0WU
CGTH-W-1 MkPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJzLkexOlYh|ryP NG\4XVJUSU6JRWK=
NCI-H661 M3n6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXX[WNKSzVyPUKyMlA{PCEQvF2= NYD3UIpHW0GQR1XS
KU-19-19 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fuS2lEPTB;MkKuNVY6PyEQvF2= NE\FZ4hUSU6JRWK=
NCI-H2122 M1rHRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX2wOVh2UUN3ME2yNk4zPDN{IN88US=> NGrKTZJUSU6JRWK=
NCI-H526 NUDtV3cyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PZVGlEPTB;MkKuN|g6PSEQvF2= MVzTRW5ITVJ?
NCI-H1650 MlfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHl[oJKSzVyPUKyMlc3PCEQvF2= NIXH[WtUSU6JRWK=
AM-38 NVnMU244T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX6zXHhIUUN3ME2yNk45Pjh7IN88US=> MXXTRW5ITVJ?
NCI-H2405 NHT0fZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjPeW1oUUN3ME2yN{4zPTN|IN88US=> MWrTRW5ITVJ?
M14 NUPRd|VbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLkTWM2OD1{Mz60NFg5KM7:TR?= M4SxZnNCVkeHUh?=
ES4 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEKycY5KSzVyPUKzMlQzOzJizszN NGDZSWlUSU6JRWK=
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IST-MEL1 M1LJbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX3TWM2OD16Nj64PFczKM7:TR?= MkHmV2FPT0WU
KP-N-YS NFP2WnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\mTWM2OD16OT65NFI5KM7:TR?= NET5cllUSU6JRWK=
KYSE-410 M{jpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETiVYtKSzVyPUmxMlQxPDJizszN MorUV2FPT0WU
TE-10 M1zHUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkW4TWM2OD17MT61OlEyKM7:TR?= M{T4dXNCVkeHUh?=
SK-MEL-1 M1\hVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nIT2lEPTB;OUKuPVExPiEQvF2= MoPqV2FPT0WU
COLO-792 NFXLZW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTl3LkK1OlQh|ryP MWHTRW5ITVJ?
SCH MlO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD6TWM2OD17Nj6zPFc4KM7:TR?= M{iwTXNCVkeHUh?=
NCI-H1792 NEDOVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTl4Lki5PVIh|ryP NEC3dnNUSU6JRWK=
NCI-H2029 MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT2Z2dZUUN3ME25Ok46PTZ4IN88US=> Mn62V2FPT0WU
SW684 NGDiTFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;4XlVKSzVyPUm4MlY3PTRizszN NYPXTnliW0GQR1XS
NCI-H209 NEPBRZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPBeHNKSzVyPUGwNE4yOjFizszN M2PoenNCVkeHUh?=
HLE M{PCfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;ZOWlEPTB;MUC1MlI5OiEQvF2= MnKzV2FPT0WU
GOTO NGC2T4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYO4bZVxUUN3ME2xNFcvPzd5IN88US=> M3q1VHNCVkeHUh?=
NCI-H1793 NUe4c5dVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHTTWM2OD1zMEmuNlgh|ryP MlTKV2FPT0WU
D-392MG NHLvOYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFzNz6zPVgh|ryP MXnTRW5ITVJ?
SW1990 NXfF[2MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF{MD65OVEh|ryP NWDncFhFW0GQR1XS
ML-2 M1;DPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXjO2lKSzVyPUGyNU43PzZizszN MVTTRW5ITVJ?
NCI-H2452 MnXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\sTWM2OD1zMkKuNlEh|ryP M4fXO3NCVkeHUh?=
SK-MEL-30 M{fFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3xTWM2OD1zMkOuNlQ1KM7:TR?= MWDTRW5ITVJ?
SN12C NWjlcHZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PodGlEPTB;MUK0MlE4PiEQvF2= NHHxWYVUSU6JRWK=
NCI-H1770 M2HJbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD0VHg3UUN3ME2xNlUvPTF2IN88US=> NVvMcpZmW0GQR1XS
SF268 NUXsPYRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn1OGlLUUN3ME2xNlYvOTV6IN88US=> NFTzOI5USU6JRWK=
BALL-1 NWDobIZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPHcmJKSzVyPUGyOk4zOyEQvF2= NVnycmE5W0GQR1XS
COLO-679 NWTJbZpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\1V2ozUUN3ME2xNlYvPzV|IN88US=> MYnTRW5ITVJ?
A2780 NYfudJdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;nUJk1UUN3ME2xNlgvQTh6IN88US=> NVOwOWhNW0GQR1XS
NCI-H1651 NWHBZ2t6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrQOXBKSzVyPUGzNU4zPDNizszN NF;zZm9USU6JRWK=
NCI-H2087 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfxXnJTUUN3ME2xN|EvPDh|IN88US=> MYjTRW5ITVJ?
U-87-MG M2TBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF|Mz62NFQh|ryP NE\xbm5USU6JRWK=
LB2518-MEL MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvEZ5RQUUN3ME2xN|UvQTl|IN88US=> NVH3fW9zW0GQR1XS
HCT-116 NVLUPXZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XnNWlEPTB;MUO3MlIyPyEQvF2= MoWzV2FPT0WU
Ca9-22 NY\he3Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTF|OT64N|Mh|ryP MlfIV2FPT0WU
COR-L88 MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7zZXFQUUN3ME2xOFIvOTRizszN NID1R25USU6JRWK=
CP50-MEL-B M4i0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7VSmx{UUN3ME2xOFQvPTBzIN88US=> NWrJO5ZLW0GQR1XS
OVCAR-8 M4S2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF2NT62N|Yh|ryP NWPQNoRQW0GQR1XS
SK-MEL-3 NXvRfo8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm2RnVVUUN3ME2xOFcvQDd6IN88US=> NV70dIh{W0GQR1XS
GT3TKB MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvPS|lKSzVyPUG0PU46OjhizszN MmjtV2FPT0WU
KYSE-450 NF3Ee5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7tTWM2OD1zNUGuOVM6KM7:TR?= MlLpV2FPT0WU
CAPAN-1 M4exRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF3Mz6wOlQh|ryP NF62RmtUSU6JRWK=
BEN MlXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTlcmVDUUN3ME2xOVMvQTJ6IN88US=> M33USXNCVkeHUh?=
NCI-H1304 M13j[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HkOWlEPTB;MUW0MlY6PCEQvF2= M3TPWXNCVkeHUh?=
KU812 NVPWS5F2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfjfWhIUUN3ME2xOVgvPjd2IN88US=> NX;se4hwW0GQR1XS
Capan-2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfSWmFKSzVyPUG2NE42PTNizszN MVzTRW5ITVJ?
A673 M4Pxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTF4MT63NFUh|ryP NGfhb|lUSU6JRWK=
SAS NFH5VJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnQdnJKSzVyPUG2Nk43PzhizszN M3;LU3NCVkeHUh?=
NY Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\0ZlBQUUN3ME2xOlUvOzF2IN88US=> NVvvPFFsW0GQR1XS
HCE-4 NFTjT4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;WTWM2OD1zNk[uPFQ2KM7:TR?= Mnq5V2FPT0WU
MDA-MB-231 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknyTWM2OD1zN{euOVA{KM7:TR?= NFHWSGxUSU6JRWK=
no-10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTF5OD6xN|Qh|ryP MX\TRW5ITVJ?
MZ7-mel NV61WJFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK2TWM2OD1zN{iuOFY4KM7:TR?= NXjpNm5WW0GQR1XS
NCI-H82 NUP3emVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTF6MD6xOlUh|ryP MW\TRW5ITVJ?
CAL-72 NGryW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHPdVZKSzVyPUG4OU4xPTRizszN MVfTRW5ITVJ?
NCI-SNU-5 NHfTcIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfGd4pQUUN3ME2xPFYvQDRizszN Mn;GV2FPT0WU
OVCAR-4 NXfi[GZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfBeXc2UUN3ME2xPFgvOzN|IN88US=> MWXTRW5ITVJ?
SCC-9 M1Oyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHXPG1KSzVyPUG5NUDPxE1? NIDHVnZUSU6JRWK=
KYSE-150 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfwTWM2OD1zOUGuPFg5KM7:TR?= NVf5VHQ5W0GQR1XS
HT-29 MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH3TWM2OD1{MEGuNlEzKM7:TR?= NV7ifmx5W0GQR1XS
COLO-678 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJyMT60OUDPxE1? NEnJb45USU6JRWK=
NCI-H650 Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJyMj6xNFMh|ryP MkjNV2FPT0WU
HuCCT1 NXfkbII4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJyND6yNFgh|ryP NXfOcWc3W0GQR1XS
SW1116 NUHsbVh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DYUmlEPTB;MkC3MlA4PyEQvF2= M13WVnNCVkeHUh?=
DBTRG-05MG NYLyNZBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[4WI1KSzVyPUKwO{46ODlizszN NEGzclRUSU6JRWK=
SW982 NG\rRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlf1TWM2OD1{MEeuPVQ5KM7:TR?= Moj0V2FPT0WU
RCM-1 NUPrR4gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJzND63OlIh|ryP MlyzV2FPT0WU
COLO-320-HSR MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WyU2lEPTB;MkG2MlEzPSEQvF2= M2XJUnNCVkeHUh?=
KNS-42 Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrz[o5KSzVyPUKxOk42PzRizszN MlXoV2FPT0WU
C2BBe1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJ|MT65NFUh|ryP MYLTRW5ITVJ?
CCRF-CEM NEnUXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJ2Mz63PVUh|ryP NG\kSHdUSU6JRWK=
SH-4 NWTIPVd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJ2Nj6wPUDPxE1? NHPDV5dUSU6JRWK=
LS-1034 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjBTWM2OD1{NE[uNlY3KM7:TR?= MVPTRW5ITVJ?
NCI-H2347 M1XuW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TDVmlEPTB;MkS3MlcyOyEQvF2= NUHtfWlPW0GQR1XS
RPMI-8866 M2T3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXveHA4UUN3ME2yOFkvOjdizszN Mki5V2FPT0WU
GAK MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJ3Mz6wNFIh|ryP M4n5SnNCVkeHUh?=
NB6 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfS[FJKSzVyPUK3NE4yKM7:TR?= NEXxUYxUSU6JRWK=
COLO-680N NWfvOnliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vYcmlEPTB;MkeyMlUzPyEQvF2= NV\Xe49mW0GQR1XS
RERF-LC-MS M{iwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTMXXVzUUN3ME2yO|YvODB5IN88US=> MVXTRW5ITVJ?
TGBC11TKB MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJ5OD6xO|gh|ryP MXLTRW5ITVJ?
C8166 M1LWd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC2RW5XUUN3ME2yO|gvPTB4IN88US=> M{TaVHNCVkeHUh?=
HDLM-2 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjDVXpKSzVyPUK5OE41ODlizszN NFjZS2FUSU6JRWK=
IGR-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHPZVNKSzVyPUK5OU43PTlizszN NE\pRXlUSU6JRWK=
FADU NIfFUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV22Row6UUN3ME2yPVcvPTFizszN MljJV2FPT0WU
L-428 NIfQXXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HCOmlEPTB;Mkm3MlYyPiEQvF2= NXXaO2ZvW0GQR1XS
LU-65 NXuzNHlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTNyND6zNkDPxE1? MWXTRW5ITVJ?
HEL MmmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\3ZWRKSzVyPUOwPU46QDNizszN M1vQ[3NCVkeHUh?=
NCI-H810 M2HFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHXTWM2OD1|MUCuOVch|ryP NUDzb|JPW0GQR1XS
C3A NUj5ZY9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\xTWM2OD1|MUGuPFAzKM7:TR?= MWfTRW5ITVJ?
NCI-H630 M3vpSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFy4eJBKSzVyPUOzNk4zQTRizszN MXrTRW5ITVJ?
KP-N-YN MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf6fotuUUN3ME2zOFEvOTJ|IN88US=> MnezV2FPT0WU
MOLT-13 NH;2RpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTvTWM2OD1|NEKuN|I3KM7:TR?= MUHTRW5ITVJ?
NCI-H1993 NUDLU4x1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[ybW1KSzVyPUO0Nk4{PjVizszN M4DOZ3NCVkeHUh?=
BE-13 NVTkeIk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTN2ND6xOlch|ryP NInPe2ZUSU6JRWK=
IST-SL1 NXPYTIF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\HTWM2OD1|NEeuOFAyKM7:TR?= MmS4V2FPT0WU
TE-9 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonHTWM2OD1|NkOuOVg6KM7:TR?= M2TzNnNCVkeHUh?=
LU-135 NIT0dmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3mxUWlEPTB;M{[3MlA{PSEQvF2= NV\xW4NFW0GQR1XS
T84 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTqfZVKSzVyPUO3OE44OTJizszN M{HNdHNCVkeHUh?=
K-562 NWezSWl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD2[JBKSzVyPUO4N{4{PiEQvF2= NWrpW5NKW0GQR1XS
SBC-5 NEHWUGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zKNmlEPTB;M{i2Mlk5PSEQvF2= MoLPV2FPT0WU
NB17 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTN7Mj61PVYh|ryP NWWxenJyW0GQR1XS
NCI-H2052 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTN7OD60O|Ih|ryP M2LzZnNCVkeHUh?=
HCC38 Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv0dWpKSzVyPUSwNU42QTNizszN MY\TRW5ITVJ?
NCI-H69 NFTqUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTR2MT6wPFMh|ryP NXH1RZA4W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

文献中の引用 (179)

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Related Akt 阻害剤

  • Afuresertib (GSK2110183)

    Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

  • AT13148

    AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.

  • SC79

    SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.

  • TIC10

    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.

  • AZD5363

    AZD5363は、有力なAkt阻害剤で、Akt1、Akt2とAkt3に作用すると、 IC50がそれぞれ 3 nM、 8 nM 、 8 nMです。

    Features:Moderate preclinical tolerability, and PD characteristics of an AKT inhibitor. Distinct profile from other AKT inhibitors in clinical development.

  • Ipatasertib (GDC-0068)

    Ipatasertib (GDC-0068)は、5nM、18nMと8nMのIC50でAkt1、Akt2とAkt3を目標としている非常に選択的な汎Akt阻害剤です。

  • GSK690693

    GSK690693は、Akt1、Akt2とAkt3を目標としている汎Akt阻害剤で、IC50 がそれぞれ 2 nM、13 nM、9 nMです。

  • Perifosine (KRX-0401)

    Perifosine (KRX-0401)は、4.7 nMのIC50による新しいAkt阻害剤です。

  • A-674563

    A-674563は、Akt1 抑制影響を示しまして、Ki が 11 nMです。

    Features:Orally bioavailable compound (achieved by replacing indole of A-443654 with phenyl moiety) and somewhat less selective for Akt over PKA than A-443654.

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