MK-2206 2HCl

MK-2206 2HCl は一種の高選択性のAkt1/2/3抑制剤で、無細胞試験でIC50値が8 nM/12 nM/65 nMそれぞれに分かれて、250種類他のタンパク質キナーゼに抑制活性を表しません。臨床2期。

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MK-2206 2HCl 化学構造
分子量: 480.39

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MSDS

製品説明

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    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HCl は一種の高選択性のAkt1/2/3抑制剤で、無細胞試験でIC50値が8 nM/12 nM/65 nMそれぞれに分かれて、250種類他のタンパク質キナーゼに抑制活性を表しません。臨床2期。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 MVjDfZRwfG:6aXOgRZN{[Xl? MmLGN{DPxE1? MYW3NkBp Mle5SG1UVw>? M36zZWlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:w NE[1c3EzODV5MUC2PS=>
A431 MkDvT4lv[XOnIFHzd4F6 M2LWN|Uh|ryP NFrH[oo2KGh? NFXDVmFFVVOR NEfP[JpUfXCycnXzd4V{KHSqZTDzbYdv[Wyrbnegc4YhSWu2IHHu[EBGemt? NH22WnczODV5MUC2PS=>
HepG2 M1yyNmN6fG:2b4jpZ{BCe3OjeR?= NISw[JgyOCEQvF2= NWnoTnJZOjRiaB?= NV;XR5hoTE2VTx?= MWjT[Y5{cXSrenXzJJJme2m|dHHueEBk\WyuczD0c{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDzc5Ji\mWwaXK= NH:2V2MzOTJyNUmyOS=>
Sk-Hep1 M{HqUGN6fG:2b4jpZ{BCe3OjeR?= MlP4NVAh|ryP NXzMUXR6OjRiaB?= NXL0PVNETE2VTx?= MYLT[Y5{cXSrenXzJJJme2m|dHHueEBk\WyuczD0c{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDzc5Ji\mWwaXK= M2DtN|IyOjB3OUK1
OCUT1 cells harbored PIK3CA (H1047R+/+) Mn;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXWXWM{OyEQvF2= MWm1JIQ> MljISG1UVw>? NW\p[2ltUUN3ME2wMlE1KM7:TR?= M2HGO|IyOjh7Mk[3
K1 cells harbored PIK3CA (E542K+/+) MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7uRmI{KM7:TR?= NVXsTHBSPSCm NUDkT4hXTE2VTx?= NHXiWlRKSzVyPUCuOVIh|ryP NH2ySYMzOTJ6OUK2Oy=>
FTC133 cells harbored PTEN (allele deletion and R130+) MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn4OIc{KM7:TR?= MVK1JIQ> M1\rXWROW09? NHuyfWpKSzVyPUCuNVgh|ryP NHTndnkzOTJ6OUK2Oy=>
C643 cells harbored HRAS (G13R+/−) MmHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XwZlMh|ryP Mo\ZOUBl MYjEUXNQ NV\tflJGUUN3ME2wMlI4KM7:TR?= M3PpUlIyOjh7Mk[3
Hth7 cells harbored NRAS (Q61R+/−) NYTWV2tqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;u[JE{KM7:TR?= NVSweXJ[PSCm M4TEfmROW09? M2[1[WlEPTB;ND61JO69VQ>? M4Tkc|IyOjh7Mk[3
TPC1 cells harbored RET/PTC1 rearrangement MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[2N{DPxE1? NVfmSXF3PSCm NV\ubXM4TE2VTx?= NEexbm1KSzVyPUCuOVkh|ryP MYGyNVI5QTJ4Nx?=
Hth74 NG\BUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFuyOGs{KM7:TR?= MV[1JIQ> NH7wT4FFVVOR MlS3TWM2OD1{LkG5JO69VQ>? MWqyNVI5QTJ4Nx?=
KAT18 NFHn[YJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PZe|Mh|ryP NUTuVnVIPSCm NEO0T2NFVVOR NVn3[IN{UUN3ME20MlYzKM7:TR?= Mly4NlEzQDl{Nke=
SW1736 M1HjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qzXlExOCEQvF2= MoPlOUBl NFGwfYNFVVOR MlPGTWM2OD12Nz61OkDPxE1? MWGyNVI5QTJ4Nx?=
WRO MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;NbI8yODByIN88US=> NHK2TIE2KGR? MkXDSG1UVw>? MYDJR|UxRjFyMECg{txO M1TUdVIyOjh7Mk[3
TAD2 NX\R[45mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfRNmEyODByIN88US=> MVi1JIQ> NW\LSlJLTE2VTx?= NFTqWHNKSzVyPkGwNFAh|ryP MYCyNVI5QTJ4Nx?=
LN229 M3;1SGFxd3C2b4Ppd{BCe3OjeR?= MXOwMlUh|ryP MUK2NEBp Mk\hSG1UVw>? M3uxcWF2\22nboTzJIFxd3C2b3flcolkKGWoZnXjeJMhd2ZiZ3XmbZRqdmmk M4PxR|IzODV5OUG0
T98G MoP4RZBweHSxc3nzJGF{e2G7 MVuwMlUh|ryP NWf6[|h3PjBiaB?= NVPwSo1bTE2VTx?= MUfBeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? M2nTTlIzODV5OUG0
HC11 NYHZ[Xo4TnWwY4Tpc44hSXO|YYm= NV;yZmp7OTBizszN NI[wNG0zPCCq M{f6NWROW09? NWHYWnNMUW6qaXLpeJMh|rJvY3Hz[YlvKGGwZDDBSHJRKHO7boTo[ZNqew>? M3XsfFIzPDJ4NkKx
MOLT-4 NYrUe|RkS3m2b4TvfIlkKEG|c3H5 MYixNEDPxE1? Ml:wOFghcA>? NYr6epZ3TE2VTx?= NUjibWhJUUN3ME2xMlfjiIoQvF2= NYPIOXl2OjJ4MUSyOFM>
CEM-R M{HsW2N6fG:2b4jpZ{BCe3OjeR?= NWS5V3lWOTBizszN MmPrOFghcA>? NXvFd49NTE2VTx?= MXnJR|UxRTNwM,MAje69VQ>? Mne0NlI3OTR{NEO=
CEM-S NVXQSHdDS3m2b4TvfIlkKEG|c3H5 Ml;ENVAh|ryP MYe0PEBp NYq2[WhoTE2VTx?= M3\rb2lEPTB;NT6x5qCK|ryP MVuyNlYyPDJ2Mx?=
MOLT-4 NHfBSIJHfW6ldHnvckBCe3OjeR?= NV\PXHkzOTBizszN MV6yOEBp NV7jdWNCTE2VTx?= NUTxboFFSmyxY3vzJINmdGy|IHnuJJRp\SCJMD;HNUBxcGG|ZTDv[kB1cGViY3XscEBkgWOuZR?= NHXZVlUzOjZzNEK0Ny=>
MOLT-4 MkjzSpVv[3Srb36gRZN{[Xl? MnK5OQKBkc7:TR?= MXy0JIg> NEPUVnJFVVOR M4PsNWlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFOzRU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? MnnvNlI3OTR{NEO=
CEM-R NIC0ZZFHfW6ldHnvckBCe3OjeR?= MlfiOQKBkc7:TR?= M2LoUVQhcA>? MmW5SG1UVw>? MlLQTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{TBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz M2\se|IzPjF2MkSz
CEM-S NFf5V2FHfW6ldHnvckBCe3OjeR?= NFHaSGE16oDLzszN MojMOEBp M3[wV2ROW09? MXHJcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFNVGvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> NXv6UnRiOjJ4MUSyOFM>
HepG2 cell Mnr4T4lv[XOnIFHzd4F6 Mk\hNlAh|ryP MV:yOEBp NEXzbIFFVVOR MVvEc5dvemWpdXzheIV{KHSqZTDwbI9{eGixconsZZRqd25ib3[gRWtV NVzsb4pXOjN5OUezNVk>
HepG2 cell NVjZXHNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPGVXk{OCEQvF2= NInVWoczPCCq NX3DfpJPTE2VTx?= NX74eo9VUW6qaXLpeJMh[2WubDDndo94fGh? Ml\zNlM4QTd|MUm=
HepG2 cell M1zNbGFxd3C2b4Ppd{BCe3OjeR?= NUOyclRwOjBizszN M1XITFI1KGh? MonaSG1UVw>? M2OxXmlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? MUWyN|c6PzNzOR?=
GEO NF\4NJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrlZpM2ODBibl2= MlHGO|IhcA>? MmPTSG1UVw>? NX62TWNtUW6qaXLpeJMh[2WubDDndo94fGh? NGTW[nkzPDV6MUKzNS=>
CNE-1 NUTWfllYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIqybJEyOCEQvF2= NFzUfJQ6PiCq MXXEUXNQ NFLjeXZKSzVyPUKuPVYh|ryP NHL2VmQzPTN|NkmyOS=>
CNE-2 NIfxfWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjOS5l[OTBizszN MmHVPVYhcA>? MU\EUXNQ M1;BNmlEPTB;ND61N{DPxE1? MmfuNlU{OzZ7MkW=
HONE-1 M4PSRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWexNEDPxE1? NFzNdYg6PiCq NHXGbHFFVVOR MXvJR|UxRTNwM{eg{txO MYGyOVM{Pjl{NR?=
SUNE-1 NGnBbHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn4NWEyOCEQvF2= MXq5OkBp MYTEUXNQ MmjKTWM2OD1yLkWyJO69VQ>? M3;oZlI2OzN4OUK1
CNE-2 MkC5SpVv[3Srb36gRZN{[Xl? MlHXNVAh|ryP M4SwOFQ5KGh? Mlv1SG1UVw>? NWPPSlFzUW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCJMR?= MUOyOVM{Pjl{NR?=
HONE-1 NFvlSlRHfW6ldHnvckBCe3OjeR?= MVuxNEDPxE1? NYTPR3Y4PDhiaB?= MlLSSG1UVw>? NVLHV4lqUW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCJMR?= M3vjRVI2OzN4OUK1
NEC8 NIW0cXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XodWlEPTB;MD6wPVY2OSEQvF2= NXjTZWI1W0GQR1XS
P12-ICHIKAWA MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXBXm5pUUN3ME2wMlEyPjJizszN MljSV2FPT0WU
MDA-MB-175-VII NHXPO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LSWWlEPTB;MD6xN|c{QCEQvF2= MVXTRW5ITVJ?
AsPC-1 M4nKOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMkKxNlIh|ryP MWPTRW5ITVJ?
T47D MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfoZVRKSzVyPUCuNlgzPSEQvF2= M3f0S3NCVkeHUh?=
HH NX;Ge3RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwM{CyPFMh|ryP NV22dY5GW0GQR1XS
MOLT-16 MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLlcWpjUUN3ME2wMlMxOzJizszN NX;l[5dlW0GQR1XS
ES5 NXT3Z|V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X5OmlEPTB;MD6zOFQ2PSEQvF2= NEDKNGJUSU6JRWK=
RS4-11 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;BS2NKSzVyPUCuN|Q3OSEQvF2= NI\wZY9USU6JRWK=
KARPAS-45 NHnXNXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX2TWM2OD1yLkO3N|IyKM7:TR?= NVThO3Y3W0GQR1XS
NCI-H720 M3\rNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnSOZh4UUN3ME2wMlM4Pjd7IN88US=> NWXvdnhjW0GQR1XS
H9 M{X4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC4cVk4UUN3ME2wMlM5QDh|IN88US=> NYPCWm5sW0GQR1XS
EFM-19 NUW3dHlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLVdJo{UUN3ME2wMlQ1ODFizszN MlTxV2FPT0WU
SBC-1 NUDIUWh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LVUmlEPTB;MD60OFA{PSEQvF2= MX\TRW5ITVJ?
A4-Fuk NITIZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHnVWQ6UUN3ME2wMlQ3QDZ6IN88US=> MUTTRW5ITVJ?
NCI-H1563 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXFTWM2OD1yLkS4NVg6KM7:TR?= NFH6fW5USU6JRWK=
HCC1419 NUn4fYFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmyTWM2OD1yLkS4PFkzKM7:TR?= NHK3O3FUSU6JRWK=
H-EMC-SS NULGZ29ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7wTWM2OD1yLkS5PVM6KM7:TR?= M1rtdHNCVkeHUh?=
BHT-101 MoTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwNUK5OlEh|ryP MmXMV2FPT0WU
IGROV-1 MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP0RnVKSzVyPUCuOVUzPDlizszN MXLTRW5ITVJ?
HGC-27 NGe5NHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmThTWM2OD1yLkW2O|g{KM7:TR?= Mln2V2FPT0WU
MDA-MB-361 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwNUe3OlEh|ryP NHzWVINUSU6JRWK=
KE-37 NVLUR4FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jxeGlEPTB;MD61PFI3KM7:TR?= MXzTRW5ITVJ?
HCC70 M3Pkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXu5No9zUUN3ME2wMlU6QDJ5IN88US=> NVrJV5N{W0GQR1XS
LNCaP-Clone-FGC NWroOohwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP4U3NKSzVyPUCuOlExPDhizszN M3flR3NCVkeHUh?=
HAL-01 MknhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUL6UZZZUUN3ME2wMlYzOTNizszN NGPoNplUSU6JRWK=
HT NUSyS|VuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD2TVdvUUN3ME2wMlY{OjN7IN88US=> NYLGflFrW0GQR1XS
MDA-MB-415 NHjNXIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwNkO2NlYh|ryP M4PpV3NCVkeHUh?=
NOS-1 NH;USm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILUemdKSzVyPUCuOlM4OjNizszN NIrxSo9USU6JRWK=
DU-145 NILEfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwNkS3OFUh|ryP NHPLOFdUSU6JRWK=
OCUB-M NVXzcnF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwN{C5OlYh|ryP NYS2OYZNW0GQR1XS
VA-ES-BJ M1q1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrSdZhKSzVyPUCuO|MxOjVizszN MYLTRW5ITVJ?
J-RT3-T3-5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi4TGlKSzVyPUCuO|Q1ODNizszN NVm3ZplRW0GQR1XS
MOLT-4 MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XlTmlEPTB;MD64NFU5OiEQvF2= MoOzV2FPT0WU
NB7 M3niRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG5WoVKSzVyPUCuPFI1OTFizszN NUe5e2tTW0GQR1XS
L-363 M{TtTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwOEO0OFIh|ryP MoPjV2FPT0WU
NKM-1 NIjEeZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzVPHA6UUN3ME2wMlg3OjV|IN88US=> NUPaZVBQW0GQR1XS
HOP-92 NVm2cHhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwOEeyNlMh|ryP M{LtTXNCVkeHUh?=
OAW-42 NWmwUodVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7s[nBKSzVyPUCuPFg4OiEQvF2= M{f3XHNCVkeHUh?=
HuO9 NGWzd4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnWyTWM2OD1yLkmyO|UyKM7:TR?= MVTTRW5ITVJ?
MFE-280 NYC1S|VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwOU[0OlUh|ryP NIfId5ZUSU6JRWK=
EM-2 NGS3TldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHPd|V3UUN3ME2wMlk4QTN7IN88US=> NYLGWWdTW0GQR1XS
NCI-H520 M4LEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwOUi1PVIh|ryP MoWxV2FPT0WU
LB2241-RCC MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwOUm3N|Qh|ryP NX7aNG5sW0GQR1XS
SK-NEP-1 MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTFwMUS0PFUh|ryP MkXPV2FPT0WU
LXF-289 NGjFWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTFwMUexOVYh|ryP MoLvV2FPT0WU
EPLC-272H NUG5dWcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHvWXpUUUN3ME2xMlE4OjV4IN88US=> M4LnWXNCVkeHUh?=
COLO-684 NWXNbZczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfaTWM2OD1zLkKzO|I2KM7:TR?= MkGyV2FPT0WU
ES1 NVu2OI5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFwMkSwOlUh|ryP NH;hdndUSU6JRWK=
DOHH-2 Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFwMkiyNFMh|ryP M3ywXHNCVkeHUh?=
CTB-1 NHvJVWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTlTWM2OD1zLkK4PVkh|ryP NHTQUIdUSU6JRWK=
G-401 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwMkm3PVUh|ryP NHWzSphUSU6JRWK=
LoVo MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zpZWlEPTB;MT6zNlU{PCEQvF2= NGXIU21USU6JRWK=
Ramos-2G6-4C10 M3iyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULvdIdZUUN3ME2xMlM{PzBzIN88US=> Mkf0V2FPT0WU
MFM-223 NV3tRZp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnrPFNFUUN3ME2xMlM1PDZzIN88US=> M3HMd3NCVkeHUh?=
PA-1 Mme0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\q[nFKSzVyPUGuN|UzPjVizszN MYHTRW5ITVJ?
697 NGrX[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:0TWM2OD1zLkO3OlE3KM7:TR?= NYPFdZh7W0GQR1XS
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ME-180 M4e2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jWdWlEPTB;MT61Olg6OSEQvF2= MmjQV2FPT0WU
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EW-18 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJwNEG5N|kh|ryP Mo\PV2FPT0WU
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LAMA-84 NFP3U4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTyTWM2OD12LkG0NVkyKM7:TR?= MULTRW5ITVJ?
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EW-11 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD3fJc{UUN3ME20MlQyQDN6IN88US=> NYXO[XplW0GQR1XS
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CAL-39 M2nKcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVX4N4Q4UUN3ME20MlczOTR4IN88US=> NGflWm9USU6JRWK=
TI-73 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;XS2RQUUN3ME20MlgxPjB7IN88US=> M1Ls[nNCVkeHUh?=
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786-0 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnmemZtUUN3ME20Mlk1Pjd|IN88US=> M1rMPXNCVkeHUh?=
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NCI-H446 Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\wU3JDUUN3ME21MlIxODB7IN88US=> NGDTWZFUSU6JRWK=
ETK-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEKzOIFKSzVyPUWuNlEyPjVizszN M3fTNHNCVkeHUh?=
BT-20 NH\XPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K4PWlEPTB;NT6yNVM2OyEQvF2= MkjyV2FPT0WU
MEL-HO M2rtT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWS2OWpDUUN3ME21MlM4OzN4IN88US=> NFr0TnZUSU6JRWK=
CAL-27 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTVwNE[zN|kh|ryP M2rjTnNCVkeHUh?=
SW872 M4HsSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PUb2lEPTB;NT61PVQzQCEQvF2= MYnTRW5ITVJ?
RPMI-2650 NHfjU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTtTWM2OD13Lk[2NVk6KM7:TR?= M{LZcXNCVkeHUh?=
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Becker NHfNRpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LRWmlEPTB;NT64OlQ4OiEQvF2= M4TPR3NCVkeHUh?=
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EW-22 NULXZ|JVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDNb29HUUN3ME22MlE6PjR7IN88US=> NVvselY4W0GQR1XS
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BFTC-909 M4Lidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHaT2V4UUN3ME22MlMxOzR3IN88US=> M4TVZnNCVkeHUh?=
NB12 Ml\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPJXmlXUUN3ME22MlM6ODdzIN88US=> MnnMV2FPT0WU
D-263MG NVzNNGl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\PTWM2OD14LkS1NVY6KM7:TR?= NE\5Z2hUSU6JRWK=
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LU-99A NGmwNGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTdwMUSzNlIh|ryP NHjPcWdUSU6JRWK=
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MC-IXC NGjydpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\nWGlEPTB;Nz60PFU4PiEQvF2= M2[zN3NCVkeHUh?=
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GB-1 M1LVUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e1[WlEPTB;Nz61OFgxPCEQvF2= M1OzNnNCVkeHUh?=
CAL-33 Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\mcWlEPTB;Nz62OlI{OyEQvF2= MYTTRW5ITVJ?
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JVM-3 M4nKd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHCOGFKSzVyPUiuNVUzPjhizszN NFHEWJRUSU6JRWK=
T98G MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqx[YxKSzVyPUiuNVgxPjdizszN NFr5SXdUSU6JRWK=
HCC1954 NYW3[WxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLHTo1PUUN3ME24MlQ2OTB2IN88US=> MmTWV2FPT0WU
SF126 Mm\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTOepgyUUN3ME24MlQ2QTN4IN88US=> MojyV2FPT0WU
LB996-RCC NEjQ[FJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO2fnNEUUN3ME24MlU{OjV5IN88US=> M2DLS3NCVkeHUh?=
SKG-IIIa NF;SSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rOemlEPTB;OD62N|A3QSEQvF2= M2fBTHNCVkeHUh?=
NCI-SNU-1 M2rifmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfGUXRKSzVyPUiuOlQ3PDNizszN NGG4VHlUSU6JRWK=
LB771-HNC M4TTOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\aNIZpUUN3ME24MlY1Pjl4IN88US=> M{C3SHNCVkeHUh?=
SCC-4 M3\nfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DkZ2lEPTB;OD62PFIyQSEQvF2= Mn3KV2FPT0WU
CAMA-1 NWHxUmpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLhd2lKSzVyPUiuO|cyPDZizszN NWGze|hsW0GQR1XS
D-502MG MlrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n1dWlEPTB;OD63PFYzQSEQvF2= MoruV2FPT0WU
ESS-1 M1SzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj5S4xKSzVyPUiuPFg4ODRizszN NGXTR|ZUSU6JRWK=
HEC-1 M1fXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX2TWM2OD16Lki5PFY3KM7:TR?= M4H2bXNCVkeHUh?=
NB10 NX;PbId5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPCcY82UUN3ME25MlAzOjJ2IN88US=> NXrWV|FQW0GQR1XS
8505C M1O3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1v1TGlEPTB;OT6wOFI{OiEQvF2= MVXTRW5ITVJ?
EFO-27 M1Lte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vNcWlEPTB;OT6xOlQyOiEQvF2= MU\TRW5ITVJ?
HN M1;mTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFmxe|JKSzVyPUmuNVY3OjhizszN M1jCcHNCVkeHUh?=
DSH1 Mmi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTlwMkC4O{DPxE1? NHfHb2VUSU6JRWK=
NBsusSR NGnXWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M373fWlEPTB;OT6yO|QxOiEQvF2= MnX0V2FPT0WU
LS-123 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnNNVM6UUN3ME25MlMyPzZzIN88US=> MlH4V2FPT0WU
SHP-77 MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrSbXJbUUN3ME25MlM6QTN3IN88US=> M2WxOHNCVkeHUh?=
ACN NVzZNJZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlizTWM2OD17LkWzNlc4KM7:TR?= NUnCUJZPW0GQR1XS
U251 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfBTWM2OD17Lk[1OVQ1KM7:TR?= M3vrenNCVkeHUh?=
A431 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\H[2lEPTB;OT64NFI{QCEQvF2= NVX6U3JUW0GQR1XS
5637 MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLoXo5KSzVyPUmuPFQ6QDRizszN MXPTRW5ITVJ?
MDA-MB-157 NIW1fWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2T3UmlEPTB;OT65Nlg4QCEQvF2= NXjhflRbW0GQR1XS
A101D MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnuTWM2OD17Lkm5PVc1KM7:TR?= NFjiOYZUSU6JRWK=
YKG-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGf0[4ZKSzVyPUGwMlIxODZizszN M1L0S3NCVkeHUh?=
LAN-6 NV3pOI9mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;XTIVKSzVyPUGwMlIyPjRizszN NF7UdXFUSU6JRWK=
OVCAR-5 M1XvZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjDZnFKSzVyPUGwMlI1OzNizszN NYrlXGlrW0GQR1XS
A549 M2jRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvmSopuUUN3ME2xNE4{QTd|IN88US=> M2TKeHNCVkeHUh?=
no-11 NVP2UG5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jQN2lEPTB;MUCuOFM2OyEQvF2= NUO4PGJQW0GQR1XS
SF539 NGKyTldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFyLkmwOFEh|ryP M{jBUnNCVkeHUh?=
A388 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Kx[mlEPTB;MUGuN|g6PyEQvF2= NG\kU3pUSU6JRWK=
DEL Mki5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjlV4dKUUN3ME2xNU41OjRizszN MnnkV2FPT0WU
SW954 MljqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUj3Z2h7UUN3ME2xNU41PjZ6IN88US=> MX3TRW5ITVJ?
TK10 M1XX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T2c2lEPTB;MUGuOVI4OSEQvF2= NXvHOWpvW0GQR1XS
SW756 Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFzLkWyPVQh|ryP M3HifHNCVkeHUh?=
PC-3 MmS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L4eGlEPTB;MUGuOVc3PCEQvF2= MorOV2FPT0WU
ONS-76 M4X6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jtbGlEPTB;MUGuOlM3KM7:TR?= NH;J[IpUSU6JRWK=
A427 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4i2R2lEPTB;MUGuO|A6OyEQvF2= NHnmWFZUSU6JRWK=
MEG-01 M1X6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTFzLke1NFkh|ryP NFf5cZBUSU6JRWK=
BB30-HNC NXGzR5FCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULRNXJUUUN3ME2xNU44QTh{IN88US=> Mn75V2FPT0WU
NCI-H1299 NWXnfIRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFzLkiwPVMh|ryP MWnTRW5ITVJ?
GCT MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHOPJd6UUN3ME2xNU45OjJ6IN88US=> MUHTRW5ITVJ?
D-247MG NFzTfWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFzLkm2OlMh|ryP NVq2bZlrW0GQR1XS
CFPAC-1 NHX1VYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFzLkm3PFIh|ryP MnTBV2FPT0WU
EKVX NXPEWIVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\OeZJKSzVyPUGyMlA{OTNizszN Mmj1V2FPT0WU
CAL-51 M1HDTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF{LkC3NVYh|ryP NFTqdldUSU6JRWK=
BB49-HNC NGHDW3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTF{LkGxO|ch|ryP MnSxV2FPT0WU
RPMI-7951 NUjaPXA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofETWM2OD1zMj6xPFU1KM7:TR?= NVTzcnZWW0GQR1XS
RH-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILz[IFKSzVyPUGyMlIyQDRizszN NYnTe41UW0GQR1XS
BCPAP MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET3R2hKSzVyPUGyMlQ4PDlizszN MXHTRW5ITVJ?
GCIY NGW4N2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDmR5ZKSzVyPUGyMlUzODlizszN MYTTRW5ITVJ?
KNS-81-FD NGH4WJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTBTWM2OD1zMj61PFY6KM7:TR?= MXXTRW5ITVJ?
KYSE-140 NGPybJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jVTGlEPTB;MUKuPFU6PSEQvF2= NGrhU|hUSU6JRWK=
Ca-Ski NEXvc4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTlXZRKUUN3ME2xNk46ODRzIN88US=> NFe2bodUSU6JRWK=
TGBC1TKB M1vkOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLyTWM2OD1zMj65NVE2KM7:TR?= M{Ptd3NCVkeHUh?=
HCC1187 NI\1WmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjvZmJKSzVyPUGzMlE6OTJizszN NI[0epJUSU6JRWK=
SJSA-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M124NWlEPTB;MUOuNlMzPyEQvF2= MWPTRW5ITVJ?
CTV-1 NU\NXFdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTF|LkO0OUDPxE1? NFHy[WZUSU6JRWK=
WM-115 NUfCd497T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zmNmlEPTB;MUOuOlQ5OyEQvF2= MVvTRW5ITVJ?
CHP-212 NHjwU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPaU5RKSzVyPUGzMlk4OzlizszN MWHTRW5ITVJ?
SCC-15 M4HpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\S[5ZoUUN3ME2xN{46Pzd3IN88US=> MXXTRW5ITVJ?
BPH-1 NEX2fHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELaUWxKSzVyPUG0MlE3PjRizszN NF\sfZRUSU6JRWK=
SW780 NXj1UXFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmzOnFIUUN3ME2xOE42ODJ3IN88US=> MXnTRW5ITVJ?
NCI-H2291 NFixO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTF2LkW4O|gh|ryP NXzKVnVOW0GQR1XS
JEG-3 M{XyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH2XHZJUUN3ME2xOE43OzJ4IN88US=> MYfTRW5ITVJ?
CAL-120 MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYSzPY14UUN3ME2xOE44ODJ5IN88US=> MYDTRW5ITVJ?
NCI-H23 NWHySId5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHhcWZKSzVyPUG0Mlc6QTdizszN MULTRW5ITVJ?
MS-1 NHvGR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljFTWM2OD1zND65OlEyKM7:TR?= MYTTRW5ITVJ?
PC-14 MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfFTWM2OD1zND65OlU1KM7:TR?= NGP6fHlUSU6JRWK=
D-283MED MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\IT2lEPTB;MUWuNFEyOSEQvF2= MkD5V2FPT0WU
OE19 MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWCxdIFHUUN3ME2xOU4yPTRzIN88US=> MmTmV2FPT0WU
CAS-1 MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfBO|dKUUN3ME2xOU41OTh2IN88US=> MXLTRW5ITVJ?
NCI-H727 MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XsNmlEPTB;MUWuOFIzOSEQvF2= M2ezfXNCVkeHUh?=
SiHa NF7kS5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTF3Lke1PVQh|ryP MlvwV2FPT0WU
BFTC-905 MmPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTqNot6UUN3ME2xOU44Pjl2IN88US=> NYrvfVZ2W0GQR1XS
MDA-MB-453 M{HqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmO2TWM2OD1zNj6xOlQzKM7:TR?= Mon3V2FPT0WU
HuP-T3 MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTF4Lk[zO|Mh|ryP M1zzUnNCVkeHUh?=
SK-LU-1 NVT3bJA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULwVphXUUN3ME2xOk43QTV4IN88US=> NXXndGp4W0GQR1XS
Detroit562 M2fXeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\YTWM2OD1zNj63N|E5KM7:TR?= NXTBUJRpW0GQR1XS
HCC1569 NVS5dpRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmSwTWM2OD1zNj64N|M4KM7:TR?= NYXsTXlvW0GQR1XS
SK-MES-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HmV2lEPTB;MU[uPFQyQSEQvF2= Mk[5V2FPT0WU
BB65-RCC NUH5R5k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKzcY1vUUN3ME2xO{4xPDd7IN88US=> MoS0V2FPT0WU
LOXIMVI MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXT1W|ZHUUN3ME2xO{4xPzB5IN88US=> NEG4VZRUSU6JRWK=
SW1783 NHjzXolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2S5dmlEPTB;MUeuNVI5KM7:TR?= MniyV2FPT0WU
NH-12 NF\QOYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3JZ3RbUUN3ME2xO{4{OzB|IN88US=> M2PUVXNCVkeHUh?=
UACC-257 MnXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILoOHFKSzVyPUG3MlU2OTJizszN MYTTRW5ITVJ?
KOSC-2 M3nXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlniTWM2OD1zNz62O|U4KM7:TR?= NEG4VJBUSU6JRWK=
KG-1 M1n3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXq4OY1IUUN3ME2xO{43QTN5IN88US=> NYW2TGFDW0GQR1XS
M059J M2fJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37oPGlEPTB;MUeuO|A{KM7:TR?= NUfZXlE{W0GQR1XS
MHH-NB-11 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPod4RXUUN3ME2xO{46Pjd|IN88US=> MUTTRW5ITVJ?
EW-1 MkPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF6LkGzPFIh|ryP M1nj[XNCVkeHUh?=
CAL-85-1 NFSwZmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjVTWM2OD1zOD6yN|U4KM7:TR?= MmDKV2FPT0WU
639-V NE[4Z|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTXV5E4UUN3ME2xPE4{OzV2IN88US=> M2X0VXNCVkeHUh?=
C32 M2TiVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDGZoMzUUN3ME2xPE41PzJ5IN88US=> NF\lUY5USU6JRWK=
KM-H2 MlvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[2emlEPTB;MUiuOVI{OiEQvF2= NXjRcHk4W0GQR1XS
A253 M1Lwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XHO2lEPTB;MUiuO|I5PiEQvF2= Ml\kV2FPT0WU
NCI-N87 M2T6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF6LkmwNFgh|ryP NHXLUpdUSU6JRWK=
8-MG-BA MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF7LkC2OFYh|ryP NWfxR4I3W0GQR1XS
GI-ME-N M{DhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTF7LkG1OFYh|ryP NYrFUFc5W0GQR1XS
8305C NELBbZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7UN25xUUN3ME2xPU4zOjh4IN88US=> MUfTRW5ITVJ?
TE-8 NXHxeotmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXxWXQ2UUN3ME2xPU4{ODJ2IN88US=> NXr0[5RlW0GQR1XS
KYSE-270 NHXpNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fNc2lEPTB;MkCuNFIyPyEQvF2= MlnvV2FPT0WU
HL-60 NGL3PYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonsTWM2OD1{MD6wPVQyKM7:TR?= MnjjV2FPT0WU
Mo-T NUPjNoxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJyLkG2OlUh|ryP NYDiWJdVW0GQR1XS
NCI-H1355 M{Sz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH6XmNKSzVyPUKwMlM{PzRizszN MXPTRW5ITVJ?
HT-1080 M3PxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnVXmxKSzVyPUKwMlU1QTdizszN M1fYe3NCVkeHUh?=
MIA-PaCa-2 NWTK[FFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KzXGlEPTB;MkCuOlg5OyEQvF2= MV7TRW5ITVJ?
NCI-H441 NFnrO2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvDTWM2OD1{MD63N|c6KM7:TR?= NUnmSFl4W0GQR1XS
LCLC-97TM1 M4XCNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPhU|RKSzVyPUKwMlgyOzRizszN MXLTRW5ITVJ?
HT-3 MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJzLkW2N|Eh|ryP NYXkdGNpW0GQR1XS
22RV1 NULvdXBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvOSI9KSzVyPUKxMlU3QDVizszN NVT4XmFQW0GQR1XS
LK-2 NIToOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f2V2lEPTB;MkGuOVk2OyEQvF2= MUjTRW5ITVJ?
CW-2 NVHl[JhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HGWmlEPTB;MkGuOlA3QSEQvF2= M1PDZnNCVkeHUh?=
KYSE-510 Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPsepQzUUN3ME2yNU43ODl3IN88US=> MUDTRW5ITVJ?
CGTH-W-1 MlW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\ZSpNDUUN3ME2yNU44OTZ4IN88US=> MXHTRW5ITVJ?
NCI-H661 NHjXS4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ{LkCzOEDPxE1? MnjyV2FPT0WU
KU-19-19 MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jz[2lEPTB;MkKuNVY6PyEQvF2= MnLyV2FPT0WU
NCI-H2122 M1Xvfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXOe3JNUUN3ME2yNk4zPDN{IN88US=> M1mxW3NCVkeHUh?=
NCI-H526 M{HrUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLmd2tKSzVyPUKyMlM5QTVizszN MYXTRW5ITVJ?
NCI-H1650 Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJ{Lke2OEDPxE1? M2\ZNnNCVkeHUh?=
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NCI-H2405 M1jv[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy4NYg1UUN3ME2yN{4zPTN|IN88US=> NGrI[npUSU6JRWK=
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GAK NVrHOJZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJ3Mz6wNFIh|ryP MXzTRW5ITVJ?
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FADU MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrqeY1KSzVyPUK5O{42OSEQvF2= MWnTRW5ITVJ?
L-428 MlnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJ7Nz62NVYh|ryP NVX3dGhnW0GQR1XS
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HEL Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTNyOT65PFMh|ryP MkjnV2FPT0WU
NCI-H810 NHL5SFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTNzMD61O{DPxE1? MWfTRW5ITVJ?
C3A MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonyTWM2OD1|MUGuPFAzKM7:TR?= MVLTRW5ITVJ?
NCI-H630 MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\DTWM2OD1|M{KuNlk1KM7:TR?= NXTXcVRVW0GQR1XS
KP-N-YN MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljuTWM2OD1|NEGuNVI{KM7:TR?= MmHlV2FPT0WU
MOLT-13 NHjve5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXQOoxKSzVyPUO0Nk4{OjZizszN MlfDV2FPT0WU
NCI-H1993 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fCfmlEPTB;M{SyMlM3PSEQvF2= NEDiTnNUSU6JRWK=
BE-13 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\LU2NKSzVyPUO0OE4yPjdizszN MoKzV2FPT0WU
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TE-9 MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFK2WZJKSzVyPUO2N{42QDlizszN MmPDV2FPT0WU
LU-135 MkfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3oNlJpUUN3ME2zOlcvODN3IN88US=> MoXBV2FPT0WU
T84 MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3ZXXI3UUN3ME2zO|QvPzF{IN88US=> NFjYc|lUSU6JRWK=
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SBC-5 NFjRR2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN6Nj65PFUh|ryP NXe4PZAyW0GQR1XS
NB17 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjWO5FVUUN3ME2zPVIvPTl4IN88US=> NInsTpRUSU6JRWK=
NCI-H2052 M{O5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHnWYFRUUN3ME2zPVgvPDd{IN88US=> Mo\2V2FPT0WU
HCC38 MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF6xRmxKSzVyPUSwNU42QTNizszN M3jwfXNCVkeHUh?=
NCI-H69 NYfle21jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy1NXBUUUN3ME20OFEvODh|IN88US=> MmT3V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

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Frequently Asked Questions

  • Question 1
    I would want to know if MK-2206 could cross the blood brain barrier?

    Answer: MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

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