MK-2206 2HCl 化学構造
分子量: 480.39

高品質保証

文献中の引用(178)

カスタマーフィードバック(18)

Quality Control & MSDS

製品説明

  • Compare Akt Inhibitors
    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HClは高度選択的に Akt1, Akt2 and Akt3を抑制して、 IC50がそれぞれ 8 nM, 12 nM と 65 nMになる。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 M1z2WGN6fG:2b4jpZ{BCe3OjeR?= MUOzJO69VQ>? MYK3NkBp MlHWSG1UVw>? MnjaTY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25? NEn0THUzODV5MUC2PS=>
A431 NX3nd4hVU2mwYYPlJGF{e2G7 NF\RWJQ2KM7:TR?= MmTlOUBp NWHn[4VNTE2VTx?= NW[yUWd2W3WycILld5NmeyC2aHWgd4lodmGuaX7nJI9nKEGtdDDhcoQhTXKt NV3Wem13OjB3N{GwOlk>
HepG2 MmXRR5l1d3SxeHnjJGF{e2G7 MUexNEDPxE1? NHjFd3gzPCCq M3;L[mROW09? NV7Dfo5QW2Wwc3n0bZpmeyC{ZYPpd5RidnRiY3XscJMhfG9idHjlJIN6fG:2b4jpZ{Bm\m[nY4Sgc4Yhe2:{YX\lcolj Ml\zNlEzODV7MkW=
Sk-Hep1 M3XM[GN6fG:2b4jpZ{BCe3OjeR?= MWqxNEDPxE1? Mn\FNlQhcA>? MkDRSG1UVw>? MXTT[Y5{cXSrenXzJJJme2m|dHHueEBk\WyuczD0c{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDzc5Ji\mWwaXK= M{LzdFIyOjB3OUK1
OCUT1 cells harbored PIK3CA (H1047R+/+) NXHIe2xCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL2TXI{KM7:TR?= M4Xnc|Uh\A>? Ml\hSG1UVw>? NXPNOWxYUUN3ME2wMlE1KM7:TR?= NWSzXZVWOjF{OEmyOlc>
K1 cells harbored PIK3CA (E542K+/+) MmLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETyTpk{KM7:TR?= MVy1JIQ> MkXzSG1UVw>? MmjZTWM2OD1yLkWyJO69VQ>? NFHXdmkzOTJ6OUK2Oy=>
FTC133 cells harbored PTEN (allele deletion and R130+) MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nsTlMh|ryP NWfWclNPPSCm NYHjTlVtTE2VTx?= MknVTWM2OD1yLkG4JO69VQ>? NGm1ZVkzOTJ6OUK2Oy=>
C643 cells harbored HRAS (G13R+/−) M1nROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33H[FMh|ryP NULhOoFvPSCm MmK0SG1UVw>? MojTTWM2OD1yLkK3JO69VQ>? MkjxNlEzQDl{Nke=
Hth7 cells harbored NRAS (Q61R+/−) MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfVSFM{KM7:TR?= Ml3KOUBl NV3uSXA{TE2VTx?= MWjJR|UxRTRwNTFOwG0> NIr0c2IzOTJ6OUK2Oy=>
TPC1 cells harbored RET/PTC1 rearrangement NEHsXFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M170fFMh|ryP NHG5SWc2KGR? MnrISG1UVw>? MVfJR|UxRTBwNUmg{txO NUPUNo52OjF{OEmyOlc>
Hth74 NFTJeIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\IdlMh|ryP M{[2dlUh\A>? MX3EUXNQ NH\ZXoJKSzVyPUKuNVkh|ryP M{j4OVIyOjh7Mk[3
KAT18 M1nVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;tW2N{OyEQvF2= M2LtZVUh\A>? NUT3fY9QTE2VTx?= M{i1S2lEPTB;ND62NkDPxE1? NU\Sd3FwOjF{OEmyOlc>
SW1736 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TqWFExOCEQvF2= MX21JIQ> NGixfIpFVVOR NW\FXpFFUUN3ME20O{42PiEQvF2= Mom0NlEzQDl{Nke=
WRO MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7abnMyODByIN88US=> M1vicVUh\A>? NH\nSplFVVOR MYHJR|UxRjFyMECg{txO M12wV|IyOjh7Mk[3
TAD2 MoXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjzO3YyODByIN88US=> Ml;EOUBl NHLzcYhFVVOR MUTJR|UxRjFyMECg{txO NISyXGMzOTJ6OUK2Oy=>
LN229 MY\BdI9xfG:|aYOgRZN{[Xl? MY[wMlUh|ryP MYC2NEBp NGfKWlRFVVOR NVnrdnJISXWpbXXueJMh[XCxcITv[4VvcWNiZX\m[YN1eyCxZjDn[YZqfGmwaXK= MkXhNlIxPTd7MUS=
T98G MlnFRZBweHSxc3nzJGF{e2G7 MmPSNE42KM7:TR?= M4LlV|YxKGh? NUC0Oo5DTE2VTx?= MVPBeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? Mm\1NlIxPTd7MUS=
HC11 MmfVSpVv[3Srb36gRZN{[Xl? NVfKU29pOTBizszN NYTBVG45OjRiaB?= MX\EUXNQ NUPwPVYyUW6qaXLpeJMh|rJvY3Hz[YlvKGGwZDDBSHJRKHO7boTo[ZNqew>? MViyNlQzPjZ{MR?=
MOLT-4 NETIeZlEgXSxdH;4bYMhSXO|YYm= NELLPFYyOCEQvF2= MkDhOFghcA>? Ml\OSG1UVw>? NGLQeVVKSzVyPUGuO-KBkc7:TR?= MmfPNlI3OTR{NEO=
CEM-R NVHXUIFuS3m2b4TvfIlkKEG|c3H5 NWTNd41sOTBizszN MlXROFghcA>? M{HRUGROW09? NUPH[WNEUUN3ME2zMlPjiIoQvF2= MlHvNlI3OTR{NEO=
CEM-S MXfDfZRwfG:6aXOgRZN{[Xl? NXvXbJBGOTBizszN NGfJXZg1QCCq M2[5S2ROW09? NFL0dHBKSzVyPUWuNgKBkc7:TR?= NGPFO2gzOjZzNEK0Ny=>
MOLT-4 NV70d|ZsTnWwY4Tpc44hSXO|YYm= NIDUSHEyOCEQvF2= MViyOEBp M4CzXmROW09? MUDCcI9kc3NiY3XscJMhcW5idHjlJGcxN0dzIIDoZZNmKG:oIITo[UBk\WyuIHP5Z4xm M3vIWFIzPjF2MkSz
MOLT-4 NIHR[ZdHfW6ldHnvckBCe3OjeR?= NX7uT2JJPOLCid88US=> NWjNc2w4PCCq NH\0fXFFVVOR MVPJcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFM1GvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> NEHiWlAzOjZzNEK0Ny=>
CEM-R NHfS[llHfW6ldHnvckBCe3OjeR?= M3vTeVTjiIoQvF2= NXrDZoVDPCCq MXLEUXNQ NF3yZlFKdmO{ZXHz[ZMhfGinIHHtc5VvfCCxZjDjcIVifmWmIFzDOGEwSixiYTD3[YxtNWW|dHHicIl{cGWmIHH1eI9xcGGpeTDtZZJs\XJ? NUezNIJ5OjJ4MUSyOFM>
CEM-S NYrtbJlTTnWwY4Tpc44hSXO|YYm= NEW4cnA16oDLzszN M2PxVFQhcA>? NX7mWY16TE2VTx?= MlTrTY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{XBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz NWG0[IE{OjJ4MUSyOFM>
HepG2 cell M{LCOmtqdmG|ZTDBd5NigQ>? MnjBNlAh|ryP MkDnNlQhcA>? M1v0c2ROW09? NWnHRo5nTG:5boLl[5Vt[XSnczD0bIUheGixc4Doc5J6dGG2aX;uJI9nKEGNVB?= MY[yN|c6PzNzOR?=
HepG2 cell NUnKSHZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIi2OVU{OCEQvF2= MXGyOEBp NF;VOodFVVOR M3fzd2lvcGmkaYTzJINmdGxiZ4Lve5Rp NXXSXFM4OjN5OUezNVk>
HepG2 cell M3[yWWFxd3C2b4Ppd{BCe3OjeR?= MYqyNEDPxE1? NHeyWVEzPCCq NHLRXnpFVVOR MnPTTY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? MXuyN|c6PzNzOR?=
GEO M4q1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorGOVAxKG6P MmPNO|IhcA>? MkLCSG1UVw>? NYDBUXM4UW6qaXLpeJMh[2WubDDndo94fGh? NYnQc5ZUOjR3OEGyN|E>
CNE-1 NHTHd5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWKxNEDPxE1? M1mwXVk3KGh? NF;OXIpFVVOR MVXJR|UxRTJwOU[g{txO Ml\MNlU{OzZ7MkW=
CNE-2 MmHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrzcmsyOCEQvF2= MYC5OkBp MVPEUXNQ M1W1T2lEPTB;ND61N{DPxE1? NYj2V2ZKOjV|M{[5NlU>
HONE-1 NFvqTZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWxNEDPxE1? MXK5OkBp MXvEUXNQ MnnWTWM2OD1|LkO3JO69VQ>? NV\3SZliOjV|M{[5NlU>
SUNE-1 MkPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHQUZIyOCEQvF2= Mo[wPVYhcA>? NFHRUVlFVVOR NIC3ZY1KSzVyPUCuOVIh|ryP MlH1NlU{OzZ7MkW=
CNE-2 NYDtR5JSTnWwY4Tpc44hSXO|YYm= MoHYNVAh|ryP MUS0PEBp MW\EUXNQ NILpOHdKdmS3Y3XzJINmdGxiY4njcIUh[XK{ZYP0JIF1KEdz NWr5cpRQOjV|M{[5NlU>
HONE-1 NYPEXYJ[TnWwY4Tpc44hSXO|YYm= NXu0N2gyOTBizszN M{DYNlQ5KGh? NH2wSWdFVVOR MX7JcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy NXnXbGlYOjV|M{[5NlU>
NEC8 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHNTWM2OD1yLkC5OlUyKM7:TR?= MkDPV2FPT0WU
P12-ICHIKAWA NEXudmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMUG2NkDPxE1? NE\5e4FUSU6JRWK=
MDA-MB-175-VII NF\oWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMUO3N|gh|ryP MmW1V2FPT0WU
AsPC-1 Mom3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jHWWlEPTB;MD6yNlEzOiEQvF2= MnXXV2FPT0WU
T47D NHGzWJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTGUJdKSzVyPUCuNlgzPSEQvF2= NUHsbItXW0GQR1XS
HH NXnCUmluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjKXWozUUN3ME2wMlMxOjh|IN88US=> NInqRllUSU6JRWK=
MOLT-16 M{fuNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHMTWM2OD1yLkOwN|Ih|ryP NG[y[llUSU6JRWK=
ES5 M{\zRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwM{S0OVUh|ryP MUXTRW5ITVJ?
RS4-11 NWjPbXd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz1XmNKSzVyPUCuN|Q3OSEQvF2= NE\5TItUSU6JRWK=
KARPAS-45 NXfWSGMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwM{ezNlEh|ryP M3rQenNCVkeHUh?=
NCI-H720 NX7nbG5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELIW5dKSzVyPUCuN|c3PzlizszN NHro[4xUSU6JRWK=
H9 NF[yT5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjvUXVKSzVyPUCuN|g5QDNizszN NV3TbXJRW0GQR1XS
EFM-19 M1n1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3Rc5NKSzVyPUCuOFQxOSEQvF2= MmLGV2FPT0WU
SBC-1 M4\0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXnXIdPUUN3ME2wMlQ1ODN3IN88US=> M4fReHNCVkeHUh?=
A4-Fuk NV;2OVVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXITWM2OD1yLkS2PFY5KM7:TR?= MoP2V2FPT0WU
NCI-H1563 NYGyfJpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r3W2lEPTB;MD60PFE5QSEQvF2= NGPP[4pUSU6JRWK=
HCC1419 M4\YRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPOTWM2OD1yLkS4PFkzKM7:TR?= M3rLPHNCVkeHUh?=
H-EMC-SS NYXEdWNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXGzd|lJUUN3ME2wMlQ6QTN7IN88US=> M3XkN3NCVkeHUh?=
BHT-101 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLWTWM2OD1yLkWyPVYyKM7:TR?= M3mxbXNCVkeHUh?=
IGROV-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwNUWyOFkh|ryP NYS2bpU1W0GQR1XS
HGC-27 MlKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHwTWM2OD1yLkW2O|g{KM7:TR?= NFmwb4lUSU6JRWK=
MDA-MB-361 NHizUVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvBZVNLUUN3ME2wMlU4PzZzIN88US=> NEXJNlBUSU6JRWK=
KE-37 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C4OGlEPTB;MD61PFI3KM7:TR?= NEjKTXVUSU6JRWK=
HCC70 NFr4cWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrud4t2UUN3ME2wMlU6QDJ5IN88US=> NWPmV|VYW0GQR1XS
LNCaP-Clone-FGC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfYUY9KSzVyPUCuOlExPDhizszN MWTTRW5ITVJ?
HAL-01 M4DYOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknRTWM2OD1yLk[yNVMh|ryP NE\o[FNUSU6JRWK=
HT M{PhOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S2U2lEPTB;MD62N|I{QSEQvF2= M3SweHNCVkeHUh?=
MDA-MB-415 NWPOUVhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwNkO2NlYh|ryP MoP1V2FPT0WU
NOS-1 NVmyPYFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP0SppKSzVyPUCuOlM4OjNizszN MUnTRW5ITVJ?
DU-145 M3L2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr2TWM2OD1yLk[0O|Q2KM7:TR?= NHPVTHdUSU6JRWK=
OCUB-M MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn3WXlTUUN3ME2wMlcxQTZ4IN88US=> NHfWdGdUSU6JRWK=
VA-ES-BJ Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TqOGlEPTB;MD63N|AzPSEQvF2= MkHUV2FPT0WU
J-RT3-T3-5 NXHicpZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37GN2lEPTB;MD63OFQxOyEQvF2= M3jH[HNCVkeHUh?=
MOLT-4 M2Xx[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1e5UmlEPTB;MD64NFU5OiEQvF2= NYmwXWNDW0GQR1XS
NB7 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3T1cmlEPTB;MD64NlQyOSEQvF2= MlfTV2FPT0WU
L-363 NFnIWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwOEO0OFIh|ryP NWjkWFRrW0GQR1XS
NKM-1 M3;pbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwOE[yOVMh|ryP NVHvUVBkW0GQR1XS
HOP-92 NV35OZFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjSR4JKSzVyPUCuPFczOjNizszN MXXTRW5ITVJ?
OAW-42 M1vIdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Tt[WlEPTB;MD64PFczKM7:TR?= NEXCZmxUSU6JRWK=
HuO9 NWOzc5VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwOUK3OVEh|ryP M1fNeHNCVkeHUh?=
MFE-280 NVzGNVJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwOU[0OlUh|ryP M2L0O3NCVkeHUh?=
EM-2 MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnwTWM2OD1yLkm3PVM6KM7:TR?= MXrTRW5ITVJ?
NCI-H520 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\ofGVTUUN3ME2wMlk5PTl{IN88US=> NHjNOW1USU6JRWK=
LB2241-RCC Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfTbJpvUUN3ME2wMlk6PzN2IN88US=> M3PTZ3NCVkeHUh?=
SK-NEP-1 NYPtcIpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TITGlEPTB;MT6xOFQ5PSEQvF2= MULTRW5ITVJ?
LXF-289 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnzSHA5UUN3ME2xMlE4OTV4IN88US=> NI\zdJpUSU6JRWK=
EPLC-272H Mkj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fTNmlEPTB;MT6xO|I2PiEQvF2= MYXTRW5ITVJ?
COLO-684 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfSTWM2OD1zLkKzO|I2KM7:TR?= M1nXOHNCVkeHUh?=
ES1 NHXnVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\wTWM2OD1zLkK0NFY2KM7:TR?= MUTTRW5ITVJ?
DOHH-2 M13tfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPvTWM2OD1zLkK4NlA{KM7:TR?= MX\TRW5ITVJ?
CTB-1 NH\GVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFwMki5PUDPxE1? NUC0[IRWW0GQR1XS
G-401 NYXXS4NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULHT2dPUUN3ME2xMlI6Pzl3IN88US=> NH3mcFBUSU6JRWK=
LoVo MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoC5TWM2OD1zLkOyOVM1KM7:TR?= M3H6fXNCVkeHUh?=
Ramos-2G6-4C10 M1vDO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7hUG1KSzVyPUGuN|M4ODFizszN NVH5VIhwW0GQR1XS
MFM-223 MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTFwM{S0OlEh|ryP MmrBV2FPT0WU
PA-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\S[W5KSzVyPUGuN|UzPjVizszN NYn3OpFNW0GQR1XS
697 NGjwU2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof0TWM2OD1zLkO3OlE3KM7:TR?= M{jTcnNCVkeHUh?=
QIMR-WIL NH;uTYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4KyT2lEPTB;MT60PVEyPiEQvF2= NHHKOnJUSU6JRWK=
HOS MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFwNEm1OVgh|ryP NVjycZk6W0GQR1XS
DMS-273 NUHsdY9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfjZ|N3UUN3ME2xMlUyQTV7IN88US=> MVPTRW5ITVJ?
ME-180 MnPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jJSmlEPTB;MT61Olg6OSEQvF2= NWDTTG9nW0GQR1XS
HCC2218 NYDqO25HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTFwNkiyNlUh|ryP NYrMUo8xW0GQR1XS
CAL-54 MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\2[29iUUN3ME2xMlcyOjR{IN88US=> M3Hh[XNCVkeHUh?=
OMC-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDGTWM2OD1zLke0Olc4KM7:TR?= MW\TRW5ITVJ?
COR-L105 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzrTWM2OD1zLke5O|M4KM7:TR?= NHnPcoVUSU6JRWK=
BV-173 NEOyN3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XGVmlEPTB;MT64NVA4PCEQvF2= NFjmN2FUSU6JRWK=
RKO M{PSVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrGXFRKSzVyPUGuPFcyODFizszN NHnNUGtUSU6JRWK=
SNU-387 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIriWY1KSzVyPUGuPFg1ODZizszN M4XQUnNCVkeHUh?=
SW1088 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLMTWM2OD1zLkm0OlA3KM7:TR?= MVfTRW5ITVJ?
Hs-578-T M2H0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TJRWlEPTB;Mj6xNVQ{OyEQvF2= M{T1Z3NCVkeHUh?=
OC-314 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJwMUWwPFYh|ryP MnXJV2FPT0WU
RMG-I NIDybHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HhcWlEPTB;Mj6xOlM6QCEQvF2= Mnu0V2FPT0WU
NCI-H1395 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJwMUiwPVEh|ryP MX7TRW5ITVJ?
GAMG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJwMkO4OFUh|ryP NUjSVIc5W0GQR1XS
LB1047-RCC MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j5RmlEPTB;Mj6yOFMyPyEQvF2= M3y5SHNCVkeHUh?=
MN-60 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jMV2lEPTB;Mj6yPVkzOyEQvF2= M4C4cXNCVkeHUh?=
OAW-28 MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XhfGlEPTB;Mj6yPVk2OSEQvF2= NXjG[INiW0GQR1XS
NCI-H2228 MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrnWG5KSzVyPUKuN|E2PTJizszN NH;NUIlUSU6JRWK=
ABC-1 M1WzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\5fpF2UUN3ME2yMlM{OjV|IN88US=> MULTRW5ITVJ?
LS-513 NH7lbHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[2TWM2OD1{LkOzOFg1KM7:TR?= MYnTRW5ITVJ?
KS-1 NXryXZozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\PVFhKSzVyPUKuN|gyQTFizszN MYjTRW5ITVJ?
NB69 MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnqZohqUUN3ME2yMlM5QTh|IN88US=> M13vb3NCVkeHUh?=
VM-CUB-1 NX[wSVZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;1boZKSzVyPUKuN|kxQDNizszN M{jUbnNCVkeHUh?=
D-423MG MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJwNEGwOFQh|ryP NE\nVndUSU6JRWK=
EW-18 NHHYdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTuTWM2OD1{LkSxPVM6KM7:TR?= NX3JSJF6W0GQR1XS
YH-13 MoDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJwNE[xOVMh|ryP M4fGPHNCVkeHUh?=
T-24 NULsbW5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\pcmlEPTB;Mj60O|g5OSEQvF2= NWnvcWhqW0GQR1XS
ES8 MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;adGlEPTB;Mj60PVI5PyEQvF2= MlnLV2FPT0WU
ES3 NH7NO3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK1TWM2OD1{LkS5O|U6KM7:TR?= NWK5ZnNmW0GQR1XS
RXF393 NUXMXXFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnflTWM2OD1{Lk[wOFg4KM7:TR?= Mo[xV2FPT0WU
RPMI-8226 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJwNkK5OVMh|ryP NHPqTXhUSU6JRWK=
AGS MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXMbG5KSzVyPUKuO|IyOzdizszN M37N[3NCVkeHUh?=
HCC1395 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJwN{WxPFch|ryP NIHCcplUSU6JRWK=
MV-4-11 NELRRodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1OyXGlEPTB;Mj63OVI3PiEQvF2= NFXKfppUSU6JRWK=
A204 MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLBZmhKUUN3ME2yMlg{QDd{IN88US=> NF;aRVRUSU6JRWK=
MCF7 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfKbopKSzVyPUKuPFYyOTdizszN MlPxV2FPT0WU
SNU-423 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zNNGlEPTB;Mj64PVI1OiEQvF2= NEXyO4NUSU6JRWK=
NCI-H1048 NEHjfmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:1WFBSUUN3ME2yMlk3QDZ3IN88US=> MnzsV2FPT0WU
GR-ST MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H2b2lEPTB;Mz6wOFYyOSEQvF2= MlfpV2FPT0WU
EoL-1- MkXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTNwMEewOVgh|ryP M2HiTXNCVkeHUh?=
HuH-7 NFzNcIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW5fXVUUUN3ME2zMlA6PDZ2IN88US=> MXrTRW5ITVJ?
OS-RC-2 MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDoTWM2OD1|LkGxNVkh|ryP M{XuNXNCVkeHUh?=
EW-3 NWntWlFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHYTWM2OD1|LkG5OVI6KM7:TR?= MUPTRW5ITVJ?
NCI-H747 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTNwMkC2PVQh|ryP M3XwbnNCVkeHUh?=
EW-16 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHPTWM2OD1|LkKxPFc6KM7:TR?= MVvTRW5ITVJ?
DOK NWPTZZhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTNwMkK4OVkh|ryP MUPTRW5ITVJ?
HCC2157 NV;vOWRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnWTWM2OD1|LkO4NVc6KM7:TR?= NHXrd5lUSU6JRWK=
OVCAR-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnPbmtuUUN3ME2zMlQxPzh4IN88US=> M1;i[nNCVkeHUh?=
NCI-H1623 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXiTWM2OD1|LkSxNlI1KM7:TR?= M4fYenNCVkeHUh?=
H4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHzWYVKSzVyPUOuOFU3OjZizszN NFHmU3pUSU6JRWK=
SW1710 NIrWPHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HYSWlEPTB;Mz60OlY4QCEQvF2= M{HaSXNCVkeHUh?=
RT-112 Mn3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Pj[mlEPTB;Mz61NlM5QCEQvF2= NX2zXJNmW0GQR1XS
DMS-114 MlPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fuWGlEPTB;Mz62NlI4QCEQvF2= NGrMW2FUSU6JRWK=
AN3-CA NXXFfFBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHLXW1CUUN3ME2zMlYzPDV4IN88US=> MX\TRW5ITVJ?
KNS-62 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jiNGlEPTB;Mz62N|M{QCEQvF2= NHLkOnlUSU6JRWK=
SJRH30 NW\o[2ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvGTWM2OD1|Lk[5NVIzKM7:TR?= M3HkbHNCVkeHUh?=
G-402 M{DJZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\ITWM2OD1|LkewO|EyKM7:TR?= MlvPV2FPT0WU
MHH-PREB-1 NYOx[pR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIm5eoxKSzVyPUOuO|IxOzhizszN NV;sWWx7W0GQR1XS
P30-OHK NXftN3ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HM[2lEPTB;Mz64NFk4PiEQvF2= Ml34V2FPT0WU
RVH-421 M4DMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHrcnlKSzVyPUOuPFE4QDhizszN M2fDWHNCVkeHUh?=
LU-134-A Mnm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL0dm86UUN3ME2zMlg5PDJ6IN88US=> MXPTRW5ITVJ?
ECC10 NEjsfIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYT4TJpjUUN3ME2zMlk{PjJ{IN88US=> MX\TRW5ITVJ?
TGW NUfZb412T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPjR2tXUUN3ME20MlAzOzB3IN88US=> MYPTRW5ITVJ?
MLMA MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1GxbmlEPTB;ND6wNlk3PiEQvF2= NWTRVI41W0GQR1XS
SCC-25 NV\LSndLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17afGlEPTB;ND6wOlU3PiEQvF2= NF[zT3FUSU6JRWK=
TYK-nu MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\5WmlEPTB;ND6wPVU{PCEQvF2= MXrTRW5ITVJ?
LAMA-84 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTRwMUSxPVEh|ryP MmLyV2FPT0WU
Calu-3 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P5NGlEPTB;ND6yOFQyPiEQvF2= NFrvNZZUSU6JRWK=
NCI-H460 NHnR[oRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYT4c3dIUUN3ME20MlI3PDR|IN88US=> MkWwV2FPT0WU
EGI-1 NIT1dnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jRfGlEPTB;ND6zO|c4QCEQvF2= NV;Jb|RlW0GQR1XS
NCI-H292 M4\xSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHP2THRKSzVyPUSuN|gyPDZizszN MXLTRW5ITVJ?
HCE-T M124d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfCTWM2OD12LkSxOVc6KM7:TR?= NHG0fWJUSU6JRWK=
EW-11 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLxNJhKUUN3ME20MlQyQDN6IN88US=> NV3vfHBTW0GQR1XS
ATN-1 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETJTY5KSzVyPUSuOFQ{ODRizszN NXnlT4U{W0GQR1XS
NB5 NHTBSlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPkXnVKSzVyPUSuOVM3QTdizszN MYfTRW5ITVJ?
KLE MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\CdWlEPTB;ND63NFE6QCEQvF2= MlTkV2FPT0WU
CAL-39 MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfMVHlKSzVyPUSuO|IyPDZizszN M2PHRnNCVkeHUh?=
TI-73 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jpUGlEPTB;ND64NFYxQSEQvF2= NWLuOIt3W0GQR1XS
HO-1-N-1 MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XEeWlEPTB;ND65OFIh|ryP M4nJT3NCVkeHUh?=
786-0 M2DXUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHoW5pKSzVyPUSuPVQ3PzNizszN NG\yNY9USU6JRWK=
SK-N-DZ NHWwV3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTRwOU[xOFIh|ryP Mo\wV2FPT0WU
NCI-H446 M2HRcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKweJVoUUN3ME21MlIxODB7IN88US=> M2LKRnNCVkeHUh?=
ETK-1 NWXudFN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDOZZhKSzVyPUWuNlEyPjVizszN M1zQ[XNCVkeHUh?=
BT-20 NIfQbHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\PS4FxUUN3ME21MlIyOzV|IN88US=> M2HCVnNCVkeHUh?=
MEL-HO MkLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTVwM{ezN|Yh|ryP MlTMV2FPT0WU
CAL-27 M4\1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnySmhKSzVyPUWuOFY{OzlizszN MlfBV2FPT0WU
SW872 NF[4VZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTVwNUm0Nlgh|ryP MWrTRW5ITVJ?
RPMI-2650 M{j1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW2TWM2OD13Lk[2NVk6KM7:TR?= NUHtOYZUW0GQR1XS
PFSK-1 Mm\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLNTWM2OD13LkeyO|MzKM7:TR?= NXvnNpY5W0GQR1XS
SF295 NF7rbGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzybJlzUUN3ME21MlgxPjN|IN88US=> NVLYemprW0GQR1XS
Becker NHvme5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\obWpKSzVyPUWuPFY1PzJizszN NULod49SW0GQR1XS
Saos-2 M{nGbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDabJNKSzVyPUWuPFY2OyEQvF2= MUTTRW5ITVJ?
SK-OV-3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPsTWM2OD13Lkm5PFE3KM7:TR?= MVHTRW5ITVJ?
VMRC-RCZ MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTZwMEi3O|Mh|ryP MkfUV2FPT0WU
EW-22 NIDESlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXJTWM2OD14LkG5OlQ6KM7:TR?= MojPV2FPT0WU
BT-474 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXLb2xKSzVyPU[uNlM{KM7:TR?= M2HQN3NCVkeHUh?=
BFTC-909 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PqeWlEPTB;Nj6zNFM1PSEQvF2= NFK4OXhUSU6JRWK=
NB12 NYf1RnZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTZwM{mwO|Eh|ryP MmDyV2FPT0WU
D-263MG M4qxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoizTWM2OD14LkS1NVY6KM7:TR?= MkLUV2FPT0WU
SNB75 NF73XWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHEcYd4UUN3ME22MlYxOTR|IN88US=> MVLTRW5ITVJ?
A704 M4jocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\nXWlEPTB;Nj62N|A3KM7:TR?= NIDCT2xUSU6JRWK=
NCI-H1693 NGXLPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTZwNkO2NFQh|ryP NXjLSZluW0GQR1XS
LN-405 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TFT2lEPTB;Nj63PVY4OiEQvF2= NEDTWXlUSU6JRWK=
CHL-1 NX3VOYtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\ve5ZKSzVyPU[uPFAxPzlizszN M4LKSnNCVkeHUh?=
A498 Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLLXnRKSzVyPU[uPFE6PjFizszN MWHTRW5ITVJ?
TE-12 MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv6TWM2OD14LkizPFE4KM7:TR?= NEnafoJUSU6JRWK=
TE-6 NEHUdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPlN2JSUUN3ME22Mlk{ODN6IN88US=> NIq4OXdUSU6JRWK=
AU565 MkTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVSxbZBIUUN3ME22Mlk3QTV5IN88US=> MUPTRW5ITVJ?
RD NIHzZnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzC[WlKSzVyPU[uPVgzQDRizszN MW\TRW5ITVJ?
SW1463 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nl[GlEPTB;Nz6xNVE3QCEQvF2= M4HLXHNCVkeHUh?=
LU-99A Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrabYk4UUN3ME23MlE1OzJ{IN88US=> NYXrcIN6W0GQR1XS
NCI-H28 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\GeWlEPTB;Nz6yPVI1KM7:TR?= NX;TUVlvW0GQR1XS
MC-IXC Mmj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\jR2lEPTB;Nz60PFU4PiEQvF2= NYfkblVtW0GQR1XS
GP5d NHW4SolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTdwNEi3OlQh|ryP NWD2R21TW0GQR1XS
GB-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHxTWM2OD15LkW0PFA1KM7:TR?= NHKxZ2xUSU6JRWK=
CAL-33 MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDFc|RKSzVyPUeuOlYzOzNizszN M1PLZ3NCVkeHUh?=
MSTO-211H NGHzeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2qzTWlEPTB;Nz62O|M{PiEQvF2= M2\sTXNCVkeHUh?=
TE-5 Ml31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TUVmlEPTB;Nz63PVM{PCEQvF2= NIixXlBUSU6JRWK=
D-566MG M1TEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjXU5gxUUN3ME24MlA1PDJ7IN88US=> MnXIV2FPT0WU
JVM-3 M32zdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nCfmlEPTB;OD6xOVI3QCEQvF2= NYHVbIdKW0GQR1XS
T98G MmntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjPPGdKSzVyPUiuNVgxPjdizszN NWDpbJdwW0GQR1XS
HCC1954 M4i2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M325WGlEPTB;OD60OVExPCEQvF2= MoTPV2FPT0WU
SF126 M3jTTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRThwNEW5N|Yh|ryP NUKxWod5W0GQR1XS
LB996-RCC M{jrUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHOTWM2OD16LkWzNlU4KM7:TR?= MYLTRW5ITVJ?
SKG-IIIa M13v[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;3PJJEUUN3ME24MlY{ODZ7IN88US=> Ml;oV2FPT0WU
NCI-SNU-1 NVqySGdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nLOmlEPTB;OD62OFY1OyEQvF2= NW\je2VoW0GQR1XS
LB771-HNC NEjWPZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[3TWM2OD16Lk[0Olk3KM7:TR?= M{fpWHNCVkeHUh?=
SCC-4 NX22OnFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRThwNkiyNVkh|ryP M37I[nNCVkeHUh?=
CAMA-1 NV\NZpdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRThwN{exOFYh|ryP Mmf1V2FPT0WU
D-502MG NYDENZU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRThwN{i2Nlkh|ryP NVvwVpJ3W0GQR1XS
ESS-1 M1naU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPwdYlKSzVyPUiuPFg4ODRizszN Mn;LV2FPT0WU
HEC-1 M1z0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LERWlEPTB;OD64PVg3PiEQvF2= MYnTRW5ITVJ?
NB10 NHfrOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X6bmlEPTB;OT6wNlIzPCEQvF2= NWexOItnW0GQR1XS
8505C MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHVXXk2UUN3ME25MlA1OjN{IN88US=> NF7keldUSU6JRWK=
EFO-27 NHzISXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;0ZWV{UUN3ME25MlE3PDF{IN88US=> Mk\PV2FPT0WU
HN NHzZS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTlwMU[2Nlgh|ryP MXPTRW5ITVJ?
DSH1 NVjEXosxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;zeIlKSzVyPUmuNlA5PyEQvF2= NV\LcXNRW0GQR1XS
NBsusSR MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzKZldKSzVyPUmuNlc1ODJizszN NGDUSZRUSU6JRWK=
LS-123 NUn6TWd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnSeZRNUUN3ME25MlMyPzZzIN88US=> Mk\NV2FPT0WU
SHP-77 NGfU[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjtdnBKSzVyPUmuN|k6OzVizszN MUnTRW5ITVJ?
ACN MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\CO4pnUUN3ME25MlU{Ojd5IN88US=> NIrQPINUSU6JRWK=
U251 NInyW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrWRoxKSzVyPUmuOlU2PDRizszN MmPpV2FPT0WU
A431 M3XxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjvXJdoUUN3ME25MlgxOjN6IN88US=> Mn3JV2FPT0WU
5637 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fEVmlEPTB;OT64OFk5PCEQvF2= NFHXSWZUSU6JRWK=
MDA-MB-157 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLjTWM2OD17LkmyPFc5KM7:TR?= MkLjV2FPT0WU
A101D M2r6emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nvUWlEPTB;OT65PVk4PCEQvF2= M1\XfnNCVkeHUh?=
YKG-1 MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTFyLkKwNFYh|ryP NXXJNmptW0GQR1XS
LAN-6 NETuUGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDDb|RuUUN3ME2xNE4zOTZ2IN88US=> NWH6WWpUW0GQR1XS
OVCAR-5 MnPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HwNWlEPTB;MUCuNlQ{OyEQvF2= NVrnOFVTW0GQR1XS
A549 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDETWM2OD1zMD6zPVc{KM7:TR?= NWTtN4c5W0GQR1XS
no-11 MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvLTWM2OD1zMD60N|U{KM7:TR?= NIrCS|dUSU6JRWK=
SF539 MnHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fFZmlEPTB;MUCuPVA1OSEQvF2= MmrtV2FPT0WU
A388 NXO1UYxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDnTWM2OD1zMT6zPFk4KM7:TR?= NIn2TWpUSU6JRWK=
DEL MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MontTWM2OD1zMT60NlQh|ryP NH3zdIFUSU6JRWK=
SW954 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXXeXFMUUN3ME2xNU41PjZ6IN88US=> NXixXXJjW0GQR1XS
TK10 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jIV2lEPTB;MUGuOVI4OSEQvF2= NFfxNJRUSU6JRWK=
SW756 NFLRR3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n4Z2lEPTB;MUGuOVI6PCEQvF2= M{TyeHNCVkeHUh?=
PC-3 MlLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\lfGlEPTB;MUGuOVc3PCEQvF2= MnjlV2FPT0WU
ONS-76 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnS0TWM2OD1zMT62N|Yh|ryP MnHHV2FPT0WU
A427 M{TWS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PlOWlEPTB;MUGuO|A6OyEQvF2= NIqwR5ZUSU6JRWK=
MEG-01 NGfyNYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nlUGlEPTB;MUGuO|UxQSEQvF2= MXfTRW5ITVJ?
BB30-HNC NXTTVmVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTFzLke5PFIh|ryP MYLTRW5ITVJ?
NCI-H1299 NF\vcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTFzLkiwPVMh|ryP MV\TRW5ITVJ?
GCT M3GyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljuTWM2OD1zMT64NlI5KM7:TR?= NXXHOYxxW0GQR1XS
D-247MG M3i4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj0fVJXUUN3ME2xNU46PjZ|IN88US=> NXvtc4ZpW0GQR1XS
CFPAC-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFzLkm3PFIh|ryP MXjTRW5ITVJ?
EKVX MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDXXmVpUUN3ME2xNk4xOzF|IN88US=> MYDTRW5ITVJ?
CAL-51 NVnoSVl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzXfmlKSzVyPUGyMlA4OTZizszN MXjTRW5ITVJ?
BB49-HNC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnUNndKSzVyPUGyMlEyPzdizszN NWj3e4hHW0GQR1XS
RPMI-7951 M1facmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF{LkG4OVQh|ryP MkjJV2FPT0WU
RH-1 NGX2VWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTF{LkKxPFQh|ryP M4fY[HNCVkeHUh?=
BCPAP NWXMPZFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3HdoR2UUN3ME2xNk41PzR7IN88US=> NIrjSWRUSU6JRWK=
GCIY MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF{LkWyNFkh|ryP Mlz3V2FPT0WU
KNS-81-FD M2SxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:wbmlEPTB;MUKuOVg3QSEQvF2= NVH1OG5HW0GQR1XS
KYSE-140 MkDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TJdGlEPTB;MUKuPFU6PSEQvF2= Mn;SV2FPT0WU
Ca-Ski MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF{LkmwOFEh|ryP MXPTRW5ITVJ?
TGBC1TKB NWX6SYhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPWTWM2OD1zMj65NVE2KM7:TR?= MV\TRW5ITVJ?
HCC1187 NG[3[mZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jWdWlEPTB;MUOuNVkyOiEQvF2= NWHzSYRvW0GQR1XS
SJSA-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPDTWM2OD1zMz6yN|I4KM7:TR?= NGmybo1USU6JRWK=
CTV-1 NUjmemVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknuTWM2OD1zMz6zOFUh|ryP M4ThXHNCVkeHUh?=
WM-115 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUWw[YRHUUN3ME2xN{43PDh|IN88US=> MWDTRW5ITVJ?
CHP-212 M3:3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTF|Lkm3N|kh|ryP M1fxU3NCVkeHUh?=
SCC-15 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml36TWM2OD1zMz65O|c2KM7:TR?= NYf2PXhXW0GQR1XS
BPH-1 M2Ljdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PC[2lEPTB;MUSuNVY3PCEQvF2= NY\uSnVbW0GQR1XS
SW780 NILWRXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XrcGlEPTB;MUSuOVAzPSEQvF2= NUfLO|dVW0GQR1XS
NCI-H2291 MmjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\aZXc3UUN3ME2xOE42QDd6IN88US=> NUjs[WFiW0GQR1XS
JEG-3 NYnlU2RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rTVWlEPTB;MUSuOlMzPiEQvF2= Mlv2V2FPT0WU
CAL-120 M1zQZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTPN|NKSzVyPUG0MlcxOjdizszN MXzTRW5ITVJ?
NCI-H23 NV\6RpBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnQTWM2OD1zND63PVk4KM7:TR?= MYPTRW5ITVJ?
MS-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF2Lkm2NVEh|ryP M4XzVnNCVkeHUh?=
PC-14 NH\zXGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[y[HNCUUN3ME2xOE46PjV2IN88US=> MnG1V2FPT0WU
D-283MED NHzk[G5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nsV2lEPTB;MUWuNFEyOSEQvF2= MmXrV2FPT0WU
OE19 NVPB[nY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzXR2lYUUN3ME2xOU4yPTRzIN88US=> M2DtW3NCVkeHUh?=
CAS-1 NXnWUGxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPQTWM2OD1zNT60NVg1KM7:TR?= MkjmV2FPT0WU
NCI-H727 NIjUTZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfYPHRKSzVyPUG1MlQzOjFizszN NYHzV3FtW0GQR1XS
SiHa MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXpPHNKSzVyPUG1Mlc2QTRizszN NELkUm5USU6JRWK=
BFTC-905 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF3Lke2PVQh|ryP M2XhWHNCVkeHUh?=
MDA-MB-453 M3TQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF4LkG2OFIh|ryP NFnxNoZUSU6JRWK=
HuP-T3 NXS1TVhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\yTWM2OD1zNj62N|c{KM7:TR?= MljIV2FPT0WU
SK-LU-1 NVLRdJk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTF4Lk[5OVYh|ryP MnjzV2FPT0WU
Detroit562 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13jWGlEPTB;MU[uO|MyQCEQvF2= MlrwV2FPT0WU
HCC1569 NEW2dlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TPdWlEPTB;MU[uPFM{PyEQvF2= M1m5cHNCVkeHUh?=
SK-MES-1 M4DtNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrsc4xKSzVyPUG2Mlg1OTlizszN MXXTRW5ITVJ?
BB65-RCC MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPLcoRKSzVyPUG3MlA1PzlizszN M17sXHNCVkeHUh?=
LOXIMVI M3fTVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LBcmlEPTB;MUeuNFcxPyEQvF2= M{DGV3NCVkeHUh?=
SW1783 Mm\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zubWlEPTB;MUeuNVI5KM7:TR?= NGX0VldUSU6JRWK=
NH-12 M3HI[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXaO4hKSzVyPUG3MlM{ODNizszN NInYeZRUSU6JRWK=
UACC-257 MonRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF5LkW1NVIh|ryP Mk\BV2FPT0WU
KOSC-2 NYXrWVZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTF5Lk[3OVch|ryP NFnjWJlUSU6JRWK=
KG-1 MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTycpZFUUN3ME2xO{43QTN5IN88US=> NIfjd4VUSU6JRWK=
M059J M2fZXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L4SmlEPTB;MUeuO|A{KM7:TR?= M2XMWXNCVkeHUh?=
MHH-NB-11 NUnnV5g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj5WnVKSzVyPUG3Mlk3PzNizszN MVzTRW5ITVJ?
EW-1 MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnKTWM2OD1zOD6xN|gzKM7:TR?= NEfZPWJUSU6JRWK=
CAL-85-1 M{GwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXGTWM2OD1zOD6yN|U4KM7:TR?= MoHiV2FPT0WU
639-V MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO2TWM2OD1zOD6zN|U1KM7:TR?= NUD0b3VUW0GQR1XS
C32 MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPvTWM2OD1zOD60O|I4KM7:TR?= MlnXV2FPT0WU
KM-H2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTi[Xo1UUN3ME2xPE42OjN{IN88US=> MV\TRW5ITVJ?
A253 NWTYbHBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLDR45pUUN3ME2xPE44Ojh4IN88US=> NXrCWWJsW0GQR1XS
NCI-N87 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3tUHFiUUN3ME2xPE46ODB6IN88US=> NWfhbHdjW0GQR1XS
8-MG-BA NYr4RXBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPEVG13UUN3ME2xPU4xPjR4IN88US=> MV3TRW5ITVJ?
GI-ME-N MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLhNYM4UUN3ME2xPU4yPTR4IN88US=> M3nPOHNCVkeHUh?=
8305C NXLZZ4tzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHywTXNKSzVyPUG5MlIzQDZizszN MmDiV2FPT0WU
TE-8 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHoUmZ{UUN3ME2xPU4{ODJ2IN88US=> MmfSV2FPT0WU
KYSE-270 NWXDc3prT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoT5TWM2OD1{MD6wNlE4KM7:TR?= Mo\XV2FPT0WU
HL-60 NV34SZRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3SOXM4UUN3ME2yNE4xQTRzIN88US=> MlLKV2FPT0WU
Mo-T MkfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfV[2ZMUUN3ME2yNE4yPjZ3IN88US=> MV;TRW5ITVJ?
NCI-H1355 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELrXIlKSzVyPUKwMlM{PzRizszN NXHtV3ZTW0GQR1XS
HT-1080 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJyLkW0PVch|ryP MUXTRW5ITVJ?
MIA-PaCa-2 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj2TWM2OD1{MD62PFg{KM7:TR?= NESyWWhUSU6JRWK=
NCI-H441 M1zHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHvTWM2OD1{MD63N|c6KM7:TR?= NImwWJFUSU6JRWK=
LCLC-97TM1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJyLkixN|Qh|ryP MXfTRW5ITVJ?
HT-3 NXvTeZJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJzLkW2N|Eh|ryP MkHHV2FPT0WU
22RV1 M2nITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXjTVI2UUN3ME2yNU42Pjh3IN88US=> MWjTRW5ITVJ?
LK-2 Ml3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJzLkW5OVMh|ryP MlzJV2FPT0WU
CW-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\2TWM2OD1{MT62NFY6KM7:TR?= MVHTRW5ITVJ?
KYSE-510 NEnMS2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD3Uno5UUN3ME2yNU43ODl3IN88US=> MXfTRW5ITVJ?
CGTH-W-1 M2Plc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJzLkexOlYh|ryP MljIV2FPT0WU
NCI-H661 NXzlcXZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJ{LkCzOEDPxE1? M3XoPXNCVkeHUh?=
KU-19-19 MorLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJ{LkG2PVch|ryP NEjq[WNUSU6JRWK=
NCI-H2122 M1LV[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJ{LkK0N|Ih|ryP M1i1bnNCVkeHUh?=
NCI-H526 NHrFbHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\0TWM2OD1{Mj6zPFk2KM7:TR?= MWnTRW5ITVJ?
NCI-H1650 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnrU|I4UUN3ME2yNk44PjRizszN MmTQV2FPT0WU
AM-38 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJ{Lki2PFkh|ryP MUnTRW5ITVJ?
NCI-H2405 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HlSmlEPTB;MkOuNlU{OyEQvF2= NFrDVXRUSU6JRWK=
M14 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL6TWM2OD1{Mz60NFg5KM7:TR?= NGDkZmhUSU6JRWK=
ES4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPMe5pKSzVyPUKzMlQzOzJizszN NV73TYxDW0GQR1XS
DJM-1 NGjMO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLzTWM2OD1{Mz61NlM1KM7:TR?= NF64VIFUSU6JRWK=
S-117 NHu0fJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWwW5dlUUN3ME2yN{44PjVzIN88US=> Mm\GV2FPT0WU
MZ2-MEL MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrmdoRvUUN3ME2yN{44PzV7IN88US=> MX;TRW5ITVJ?
SK-MEL-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnmNnZKSzVyPUKzMlgyOzNizszN Mn7SV2FPT0WU
HCC1806 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[ySmlEPTB;MkOuPFcxQSEQvF2= MnvaV2FPT0WU
NMC-G1 M{fSSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fEd2lEPTB;MkSuNlIzPiEQvF2= NHjI[5hUSU6JRWK=
DK-MG NH7h[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13GcGlEPTB;MkSuNlk1KM7:TR?= M2LMfXNCVkeHUh?=
SK-N-FI M1TUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJ2LkOzNFIh|ryP MXzTRW5ITVJ?
KINGS-1 M4n4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHex[o9KSzVyPUK0MlQ5PzRizszN Mly3V2FPT0WU
HCC2998 Mm\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L2[2lEPTB;MkSuOFg5PSEQvF2= M2[3XnNCVkeHUh?=
ALL-PO MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJ2Lk[xPUDPxE1? MV;TRW5ITVJ?
MPP-89 NYH0Tm11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr5TWM2OD1{NT6wOFU5KM7:TR?= M2HWXnNCVkeHUh?=
NCI-H2342 M2HENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPnR5hXUUN3ME2yOU4yQTV|IN88US=> NFrxRVRUSU6JRWK=
TE-1 NGjkcVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;WTWM2OD1{NT6zOVY{KM7:TR?= MVTTRW5ITVJ?
RH-18 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPrUHhFUUN3ME2yOU42QTF6IN88US=> MWXTRW5ITVJ?
HT-1376 M4\wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLWTWM2OD1{NT62OFY2KM7:TR?= NHT4fZhUSU6JRWK=
U-2-OS NV;QNWFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJ3Lk[4PFgh|ryP M2iy[HNCVkeHUh?=
BT-549 M4myUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Lx[2lEPTB;MkWuPVAyOSEQvF2= NVX1Onh1W0GQR1XS
NCI-H1755 M3zZSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzoSW5uUUN3ME2yOU46QTR3IN88US=> NVfIO21rW0GQR1XS
EW-13 NInrbXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq2TWM2OD1{Nj6wNlc1KM7:TR?= Mk\EV2FPT0WU
NB13 NXXzfnVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTnTWM2OD1{Nj6wPVQ6KM7:TR?= MXrTRW5ITVJ?
NUGC-3 M4jG[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7RNmJ7UUN3ME2yOk4zOTB|IN88US=> NXXNUVN[W0GQR1XS
GMS-10 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz5VHlSUUN3ME2yOk4zOzV|IN88US=> MoS1V2FPT0WU
CHP-134 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzNSYppUUN3ME2yOk4{QDZ5IN88US=> NV3QPWFQW0GQR1XS
SW962 NEnEWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:zTHFwUUN3ME2yOk42ODJzIN88US=> NGmxW2VUSU6JRWK=
SNU-449 NU\rcY51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\uPGtoUUN3ME2yO{4xQDB|IN88US=> M{LzcHNCVkeHUh?=
HuP-T4 NH\yXWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfKdoRKSzVyPUK3MlA5PzlizszN MoC4V2FPT0WU
SW948 M2XQcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvMeGlKSzVyPUK3MlE{PDRizszN NYHyT3pyW0GQR1XS
NCI-H226 M1flZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjSS2ZkUUN3ME2yO{41PTd6IN88US=> MV7TRW5ITVJ?
SK-PN-DW MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ5Lk[wNVIh|ryP MkHJV2FPT0WU
GI-1 M3ruVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr5TWM2OD1{Nz63NlEh|ryP NV;tVFlbW0GQR1XS
CAL-12T MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzNc|BKSzVyPUK4MlEyOTJizszN MYPTRW5ITVJ?
YAPC NVXuRXZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vLRWlEPTB;MkiuNlU3PCEQvF2= MkTSV2FPT0WU
SNU-C2B NUPD[Y5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJ6LkK5OlQh|ryP M3HkN3NCVkeHUh?=
RCC10RGB MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\5eW14UUN3ME2yPE42PDF5IN88US=> MoD2V2FPT0WU
ES7 MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33heGlEPTB;MkmuNVQ3PSEQvF2= MorXV2FPT0WU
PANC-03-27 NH\WcZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{OxN2lEPTB;MkmuOFQ1KM7:TR?= NIDsZY5USU6JRWK=
ES6 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJ7LkixOVch|ryP NUe0eopvW0GQR1XS
HT-1197 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfEOlRKSzVyPUOwMlA2QThizszN MorIV2FPT0WU
ZR-75-30 M4\aXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\yZWRKSzVyPUOwMlI{QDNizszN NG[wUZZUSU6JRWK=
DB M4m1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPsUppFUUN3ME2zNE41QTR{IN88US=> NWrxclZ2W0GQR1XS
OCI-AML2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrMU4l4UUN3ME2zNU4xPjlizszN NWnVRXZxW0GQR1XS
NCI-H2170 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzET4NyUUN3ME2zNU45PTF4IN88US=> NWHKT2JZW0GQR1XS
IST-MES1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjNWWhKSzVyPUOyMlI5QTdizszN NWPs[ZhXW0GQR1XS
769-P MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\YZnRKSzVyPUOyMlM3PDFizszN Mn;OV2FPT0WU
COR-L23 NFzmeG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTyTWM2OD1|Mj65NFc{KM7:TR?= M{HvOXNCVkeHUh?=
SW626 NUPXZ3dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPoVYZKSzVyPUOzMlE4PzZizszN NUjsU2RSW0GQR1XS
LU-139 NGDYemRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXuSZJTUUN3ME2zN{43PjB3IN88US=> NHnSdnpUSU6JRWK=
HT-144 NX\FTYdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTN|Lki2N{DPxE1? NEjLT2NUSU6JRWK=
CaR-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnNWFJ3UUN3ME2zN{46QDJ{IN88US=> NIDWdllUSU6JRWK=
OE33 NV24TFVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTN2LkK4OVUh|ryP NGD5RmFUSU6JRWK=
COLO-800 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLUO5ZKSzVyPUO0MlM3PDdizszN NFTUZY9USU6JRWK=
NB14 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LXSGlEPTB;M{SuOFY5PCEQvF2= NHrvS25USU6JRWK=
KURAMOCHI NF7sPWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzXXlJlUUN3ME2zOk4yOTl6IN88US=> MnvKV2FPT0WU
SW48 MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEK0cWRKSzVyPUO2MlI1PzRizszN MXvTRW5ITVJ?
Daoy MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HQdmlEPTB;M{[uOlU{QCEQvF2= NWnKNm17W0GQR1XS
TGBC24TKB MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTN4Lk[3JO69VQ>? M{HqPXNCVkeHUh?=
DU-4475 NXu2UIF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;YWmlEPTB;M{[uPVA{OyEQvF2= M{jGXHNCVkeHUh?=
SW1417 NEH1R45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTN6LkC1OVIh|ryP MkTHV2FPT0WU
EFO-21 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PhUmlEPTB;M{iuPVM1QSEQvF2= MY\TRW5ITVJ?
MG-63 NEHSdYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\he2lEPTB;M{muN|QzPCEQvF2= NGHTWpJUSU6JRWK=
LC-2-ad MknnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe2N2NzUUN3ME2zPU42PTF{IN88US=> M2\sNnNCVkeHUh?=
NOMO-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\Ee2lEPTB;M{muPFI4PCEQvF2= MWLTRW5ITVJ?
COLO-741 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1OzRWlEPTB;NECuNVMxPCEQvF2= NI\MdppUSU6JRWK=
BxPC-3 NWDZ[|AzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTRyLkW2PFYh|ryP NGDtOXhUSU6JRWK=
HSC-2 NWXwNpM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4C2d2lEPTB;NECuPVEyOyEQvF2= MXzTRW5ITVJ?
UMC-11 NVn2eWpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jDUWlEPTB;NEGuNlY{KM7:TR?= M33UO3NCVkeHUh?=
HCC1937 M2f0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTR{Lke4OFMh|ryP NFP5bIVUSU6JRWK=
Calu-6 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj1THp2UUN3ME20N{4zOzh{IN88US=> MV\TRW5ITVJ?
NCI-H1573 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjVSIE3UUN3ME20N{4{PDd5IN88US=> NF7OSHBUSU6JRWK=
SK-N-AS NIL1PXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDCTWM2OD12Mz62NFE6KM7:TR?= M1q5bnNCVkeHUh?=
PSN1 NHruTWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H2XGlEPTB;NEWuNlU1QCEQvF2= NHHSOWJUSU6JRWK=
TE-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDOTWM2OD12NT60PFQzKM7:TR?= NW\2[VRXW0GQR1XS
NCI-H1155 NXzqdY9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT4dlBRUUN3ME20OU45QTZ5IN88US=> M{Lud3NCVkeHUh?=
KM12 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR3LkmwO|Yh|ryP MlXaV2FPT0WU
RO82-W-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf0TWM2OD12Nj65PFIzKM7:TR?= NFnnPHBUSU6JRWK=
SW1573 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXPTWM2OD12Nz6zO|M3KM7:TR?= NGS0e3NUSU6JRWK=
CAKI-1 NF3MeWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnLTWM2OD12OD6yPFQ2KM7:TR?= NHXYbFhUSU6JRWK=
U-118-MG M2r3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH6NYRZUUN3ME20PE4{PzB{IN88US=> NXTzbGxrW0GQR1XS
KYSE-520 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTR6LkSwNVYh|ryP NIr1dY1USU6JRWK=
HT55 Mom3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ridGlEPTB;NEmuNVQ4PCEQvF2= NYjBZnhXW0GQR1XS
ChaGo-K-1 MnXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7oNHZzUUN3ME20PU41Pzl|IN88US=> MV7TRW5ITVJ?
IA-LM MorMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYj3WWlVUUN3ME21OE43OzJ{IN88US=> Mo\xV2FPT0WU
UACC-62 NV7yVGp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfF[Y9YUUN3ME21OU4yODR4IN88US=> NVzwUVJQW0GQR1XS
MKN7 M2nFUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDyPWhKSzVyPUW2MlAzQDVizszN NGj3W4pUSU6JRWK=
HPAF-II NWHkbmIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\1TWM2OD13Nj60NFc{KM7:TR?= M2fWbXNCVkeHUh?=
NTERA-S-cl-D1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXUTWM2OD13Nz63O|gh|ryP NY\U[5dqW0GQR1XS
FTC-133 M4rkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYexTIZOUUN3ME21PE4xQTZ7IN88US=> NFnTSYNUSU6JRWK=
MHH-ES-1 M4fNN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLxRZRbUUN3ME21PE41QDF2IN88US=> NUjEUpp[W0GQR1XS
JVM-2 NITGVZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD2TWM2OD13OD65OVA3KM7:TR?= Mnm1V2FPT0WU
TCCSUP M1rNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X4W2lEPTB;NUmuOVI4QSEQvF2= Mli5V2FPT0WU
COLO-824 M4W4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i0SmlEPTB;NkCuNFcyQSEQvF2= NEjZbZBUSU6JRWK=
647-V NFXnUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfpNYx4UUN3ME22NE4yOzR5IN88US=> NE\oNmZUSU6JRWK=
HD-MY-Z M{H1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvHTWM2OD14MD61Nlk1KM7:TR?= MVjTRW5ITVJ?
LS-411N MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3IfmVKSzVyPU[xMlM6ODNizszN M3u3bXNCVkeHUh?=
NCI-H596 M{DLZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S3ZWlEPTB;NkKuO|Q6PiEQvF2= MmTmV2FPT0WU
C-33-A MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrTTWM2OD14ND6wPVU4KM7:TR?= Mo\BV2FPT0WU
BHY MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\ad4RKSzVyPU[0MlEzPDVizszN NVW4dWZjW0GQR1XS
KGN NGXPfm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP2NmRKSzVyPU[0MlU2OTRizszN MoHPV2FPT0WU
NCI-H1092 NIXjSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnG[WxDUUN3ME22OU4xODl3IN88US=> NXL6e5FCW0GQR1XS
MZ1-PC MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTZ3LkW2OFkh|ryP M{fDWXNCVkeHUh?=
LB831-BLC NED1fW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\pW4ZKSzVyPU[1Mlg1QDFizszN NXzNT4p7W0GQR1XS
SW620 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXuXVR4UUN3ME22Ok4zODN7IN88US=> M4mycXNCVkeHUh?=
HuO-3N1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\pU2lEPTB;NkiuN|I{QCEQvF2= MVfTRW5ITVJ?
SK-HEP-1 NVvTdplkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrPTWM2OD14OT65OFg3KM7:TR?= M3GyPXNCVkeHUh?=
LCLC-103H M37KT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfBPYFKSzVyPUewMlY4ODVizszN NICzbnlUSU6JRWK=
KYSE-70 M1nDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTdyLke4N|Uh|ryP MmrRV2FPT0WU
Mewo MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfJTWM2OD15MT61NFUh|ryP M1LGUnNCVkeHUh?=
COLO-668 MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkOxTWM2OD15MT64OFUyKM7:TR?= NG\IXHZUSU6JRWK=
NCI-H522 NUjVN5NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XHeWlEPTB;N{KuN|QyOyEQvF2= MYnTRW5ITVJ?
NCI-H1437 NEPs[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHxTWM2OD15ND60NFQ5KM7:TR?= NIrLSXBUSU6JRWK=
U-266 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXG[YpJUUN3ME23OU41PTF4IN88US=> Mmj4V2FPT0WU
MC116 M2nhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHvTXhKSzVyPUe1MlU4ODhizszN MXvTRW5ITVJ?
PANC-10-05 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDweVhKSzVyPUe3MlQzPDNizszN MkC5V2FPT0WU
KYSE-180 NU\aNI86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTd5LkW0OVQh|ryP MUHTRW5ITVJ?
JAR NFXDWFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\k[mlEPTB;N{muNFU1PiEQvF2= NIrBSWJUSU6JRWK=
CAL-62 NUDyZllET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPWTWM2OD16MD6wPVUh|ryP MV7TRW5ITVJ?
A3-KAW NYjYVGVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXyTolKSzVyPUiwMlIyPTRizszN M2DZcnNCVkeHUh?=
PANC-08-13 MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRThzLkG3Olgh|ryP NEL5fZdUSU6JRWK=
HSC-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\qe2lEPTB;OEOuN|A4OSEQvF2= NVzUNGEzW0GQR1XS
HTC-C3 MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\tW2lEPTB;OEOuOFcxOiEQvF2= M3fwRnNCVkeHUh?=
KY821 M1i1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PPb2lEPTB;OESuNFg6OiEQvF2= MkHJV2FPT0WU
DoTc2-4510 M1fGR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnYS4pKSzVyPUi0MlIyQDVizszN MV7TRW5ITVJ?
NCI-H1581 NETJOndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\ETWM2OD16NT60OlQyKM7:TR?= MU\TRW5ITVJ?
KARPAS-299 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4L1WWlEPTB;OE[uNVk4PyEQvF2= NWjV[JZZW0GQR1XS
IST-MEL1 M{fMT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7qNY5KSzVyPUi2Mlg5PzJizszN NI\RNVBUSU6JRWK=
KP-N-YS MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3DUIxNUUN3ME24PU46ODJ6IN88US=> M3PrVXNCVkeHUh?=
KYSE-410 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqzTWM2OD17MT60NFQzKM7:TR?= M36w[nNCVkeHUh?=
TE-10 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n5c2lEPTB;OUGuOVYyOSEQvF2= M2DGWHNCVkeHUh?=
SK-MEL-1 M{TYcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETmbnFKSzVyPUmyMlkyODZizszN MYnTRW5ITVJ?
COLO-792 NEHSdXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlyzTWM2OD17NT6yOVY1KM7:TR?= M3y1XnNCVkeHUh?=
SCH MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTl4LkO4O|ch|ryP NH7uNJRUSU6JRWK=
NCI-H1792 NX;WRVNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\0TWM2OD17Nj64PVkzKM7:TR?= MlzKV2FPT0WU
NCI-H2029 MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf3TWM2OD17Nj65OVY3KM7:TR?= M2T3fHNCVkeHUh?=
SW684 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjrT4ZOUUN3ME25PE43PjV2IN88US=> NX;wZ4RUW0GQR1XS
NCI-H209 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrMO3BKSzVyPUGwNE4yOjFizszN MYDTRW5ITVJ?
HLE NIniV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFyNT6yPFIh|ryP M1rrZXNCVkeHUh?=
GOTO MojmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P5dGlEPTB;MUC3Mlc4PyEQvF2= MoDnV2FPT0WU
NCI-H1793 M4e4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jHdmlEPTB;MUC5MlI5KM7:TR?= M3PyU3NCVkeHUh?=
D-392MG M4nyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInkPHRKSzVyPUGxO{4{QThizszN MWPTRW5ITVJ?
SW1990 NFn5TlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Hpc2lEPTB;MUKwMlk2OSEQvF2= Mo\zV2FPT0WU
ML-2 M{XDZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7WV|NpUUN3ME2xNlEvPjd4IN88US=> NUPCO2hTW0GQR1XS
NCI-H2452 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF{Mj6yNUDPxE1? NFuxNWJUSU6JRWK=
SK-MEL-30 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTF{Mz6yOFQh|ryP M2LRXHNCVkeHUh?=
SN12C NGnjWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjiW2lKSzVyPUGyOE4yPzZizszN MnOwV2FPT0WU
NCI-H1770 NUXNd4tqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFK3SnlKSzVyPUGyOU42OTRizszN MlrGV2FPT0WU
SF268 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlywTWM2OD1zMk[uNVU5KM7:TR?= NVW3bHZzW0GQR1XS
BALL-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnrTWM2OD1zMk[uNlMh|ryP MWfTRW5ITVJ?
COLO-679 NVr0Z|IyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrDTFhKSzVyPUGyOk44PTNizszN MlTlV2FPT0WU
A2780 M{LWWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H4V2lEPTB;MUK4Mlk5QCEQvF2= NUTPUmdvW0GQR1XS
NCI-H1651 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTF|MT6yOFMh|ryP MY\TRW5ITVJ?
NCI-H2087 NX;lOYV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;zTWM2OD1zM{GuOFg{KM7:TR?= Ml\LV2FPT0WU
U-87-MG M3vSR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzUTWM2OD1zM{OuOlA1KM7:TR?= Mlz5V2FPT0WU
LB2518-MEL NEnYbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzFeWRJUUN3ME2xN|UvQTl|IN88US=> Ml;LV2FPT0WU
HCT-116 M1P4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTPdJlKSzVyPUGzO{4zOTdizszN M3zvOHNCVkeHUh?=
Ca9-22 MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHoSFhMUUN3ME2xN|kvQDN|IN88US=> NFHMZo9USU6JRWK=
COR-L88 NYHLV4E6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF2Mj6xOEDPxE1? MYjTRW5ITVJ?
CP50-MEL-B NFPQTo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF2ND61NFEh|ryP NUKydGlLW0GQR1XS
OVCAR-8 NUj6cmJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF2NT62N|Yh|ryP MVzTRW5ITVJ?
SK-MEL-3 NHjnUINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYG5SoxIUUN3ME2xOFcvQDd6IN88US=> NIL2[5VUSU6JRWK=
GT3TKB M4W0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnWZ|ZKSzVyPUG0PU46OjhizszN MX7TRW5ITVJ?
KYSE-450 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvRTGdKSzVyPUG1NU42OzlizszN MYPTRW5ITVJ?
CAPAN-1 M{XkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnYO491UUN3ME2xOVMvODZ2IN88US=> MofEV2FPT0WU
BEN NEHJfGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXCTWM2OD1zNUOuPVI5KM7:TR?= NGmxUGlUSU6JRWK=
NCI-H1304 Ml3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z5fGlEPTB;MUW0MlY6PCEQvF2= MUDTRW5ITVJ?
KU812 M3TURmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3HXnk6UUN3ME2xOVgvPjd2IN88US=> MlrCV2FPT0WU
Capan-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;EOJJKSzVyPUG2NE42PTNizszN M{\6d3NCVkeHUh?=
A673 MnO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfVeldKSzVyPUG2NU44ODVizszN NHXxUGNUSU6JRWK=
SAS Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nSc2lEPTB;MU[yMlY4QCEQvF2= NGHyR|FUSU6JRWK=
NY M1PXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\BeWpKSzVyPUG2OU4{OTRizszN NX6zeZNLW0GQR1XS
HCE-4 M2OyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTF4Nj64OFUh|ryP MmDXV2FPT0WU
MDA-MB-231 NGnjeYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ezfGlEPTB;MUe3MlUxOyEQvF2= NEHL[ZJUSU6JRWK=
no-10 NF34Z2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHyUXdKSzVyPUG3PE4yOzRizszN Mn;aV2FPT0WU
MZ7-mel MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;2XoRKSzVyPUG3PE41PjdizszN MoC4V2FPT0WU
NCI-H82 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K5VWlEPTB;MUiwMlE3PSEQvF2= MWLTRW5ITVJ?
CAL-72 M3HrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4mzUGlEPTB;MUi1MlA2PCEQvF2= NVXtTGJYW0GQR1XS
NCI-SNU-5 MmPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LZfGlEPTB;MUi2Mlg1KM7:TR?= MnnCV2FPT0WU
OVCAR-4 M1n1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17y[WlEPTB;MUi4MlM{OyEQvF2= MnnMV2FPT0WU
SCC-9 MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTF7MTFOwG0> MWDTRW5ITVJ?
KYSE-150 M1TT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDLVoQ1UUN3ME2xPVEvQDh6IN88US=> M1\Xc3NCVkeHUh?=
HT-29 MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\WSGlEPTB;MkCxMlIyOiEQvF2= NU\kWVlOW0GQR1XS
COLO-678 NEHLXGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTYTWM2OD1{MEGuOFUh|ryP MmP0V2FPT0WU
NCI-H650 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzIT5NzUUN3ME2yNFIvOTB|IN88US=> MkO5V2FPT0WU
HuCCT1 NYrmWVRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPnTWM2OD1{MESuNlA5KM7:TR?= NIr2UIhUSU6JRWK=
SW1116 MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlO5TWM2OD1{MEeuNFc4KM7:TR?= M2fBUXNCVkeHUh?=
DBTRG-05MG MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHSzSFJKSzVyPUKwO{46ODlizszN NGXDbZRUSU6JRWK=
SW982 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HuZ2lEPTB;MkC3Mlk1QCEQvF2= MU\TRW5ITVJ?
RCM-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEOxN4ZKSzVyPUKxOE44PjJizszN NITJbo1USU6JRWK=
COLO-320-HSR NV\qTHhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJzNj6xNlUh|ryP NWTCclRZW0GQR1XS
KNS-42 M3nqfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnviTWM2OD1{MU[uOVc1KM7:TR?= NGPqTHdUSU6JRWK=
C2BBe1 NWLneGJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvBSFdKSzVyPUKzNU46ODVizszN MlP1V2FPT0WU
CCRF-CEM Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJ2Mz63PVUh|ryP Mn3MV2FPT0WU
SH-4 NEHRepdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX4U5pKSzVyPUK0Ok4xQSEQvF2= MUXTRW5ITVJ?
LS-1034 MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTJ2Nj6yOlYh|ryP M37UT3NCVkeHUh?=
NCI-H2347 Mn3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fD[mlEPTB;MkS3MlcyOyEQvF2= MlHnV2FPT0WU
RPMI-8866 Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2zWWdkUUN3ME2yOFkvOjdizszN NXXFbFhbW0GQR1XS
GAK NEW1cm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPTZY1nUUN3ME2yOVMvODB{IN88US=> NHPCe|BUSU6JRWK=
NB6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnnd3BVUUN3ME2yO|AvOSEQvF2= M1zYXHNCVkeHUh?=
COLO-680N NIe0bodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT0cJJKSzVyPUK3Nk42OjdizszN NFPpRlFUSU6JRWK=
RERF-LC-MS NEjXXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTCTFRKSzVyPUK3Ok4xODdizszN MljZV2FPT0WU
TGBC11TKB NEG4SpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TjOWlEPTB;Mke4MlE4QCEQvF2= NUK1XJlHW0GQR1XS
C8166 NFHKZ45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zmTGlEPTB;Mke4MlUxPiEQvF2= Ml3LV2FPT0WU
HDLM-2 NWTKOIg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHNXFBKSzVyPUK5OE41ODlizszN MWjTRW5ITVJ?
IGR-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fpb2lEPTB;Mkm1MlY2QSEQvF2= M1u1e3NCVkeHUh?=
FADU NVfyRWFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH0fYdKSzVyPUK5O{42OSEQvF2= Mk\3V2FPT0WU
L-428 NG\XU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TOcGlEPTB;Mkm3MlYyPiEQvF2= Mo[wV2FPT0WU
LU-65 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPBTWM2OD1|MESuN|Ih|ryP MlrjV2FPT0WU
HEL NUTFVWFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfK[o9KSzVyPUOwPU46QDNizszN M1\Xd3NCVkeHUh?=
NCI-H810 NVTtcI5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\kTWM2OD1|MUCuOVch|ryP MUnTRW5ITVJ?
C3A NXP6SYV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3raN2lEPTB;M{GxMlgxOiEQvF2= NHTx[IxUSU6JRWK=
NCI-H630 NIC0cWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfFeo5KSzVyPUOzNk4zQTRizszN MU\TRW5ITVJ?
KP-N-YN MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\yVXpKSzVyPUO0NU4yOjNizszN NIDPVnZUSU6JRWK=
MOLT-13 NXjHUHk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTN2Mj6zNlYh|ryP MoW2V2FPT0WU
NCI-H1993 M4rPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTN2Mj6zOlUh|ryP NFLocGpUSU6JRWK=
BE-13 NV;MU4FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTN2ND6xOlch|ryP M{mxUXNCVkeHUh?=
IST-SL1 NIrqNYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33LTGlEPTB;M{S3MlQxOSEQvF2= M1jSdXNCVkeHUh?=
TE-9 MlXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXm[2ZDUUN3ME2zOlMvPTh7IN88US=> MXjTRW5ITVJ?
LU-135 NWPkO2c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj5TWM2OD1|NkeuNFM2KM7:TR?= NYj3[mdDW0GQR1XS
T84 NE[zU5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTN5ND63NVIh|ryP Mk\HV2FPT0WU
K-562 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvzXmdKSzVyPUO4N{4{PiEQvF2= MlLSV2FPT0WU
SBC-5 M3rOVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN6Nj65PFUh|ryP MofsV2FPT0WU
NB17 NVjCRYw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TiNGlEPTB;M{myMlU6PiEQvF2= MnWwV2FPT0WU
NCI-H2052 NXr4bGg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTN7OD60O|Ih|ryP MVfTRW5ITVJ?
HCC38 NGi2c4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluxTWM2OD12MEGuOVk{KM7:TR?= MnLsV2FPT0WU
NCI-H69 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nXOGlEPTB;NESxMlA5OyEQvF2= NWjhV45FW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

文献中の引用 (178)

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related Akt 阻害剤

  • Afuresertib (GSK2110183)

    Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

  • AT13148

    AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.

  • SC79

    SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.

  • TIC10

    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.

  • AZD5363

    AZD5363は、有力なAkt阻害剤で、Akt1、Akt2とAkt3に作用すると、 IC50がそれぞれ 3 nM、 8 nM 、 8 nMです。

    Features:Moderate preclinical tolerability, and PD characteristics of an AKT inhibitor. Distinct profile from other AKT inhibitors in clinical development.

  • Ipatasertib (GDC-0068)

    Ipatasertib (GDC-0068)は、5nM、18nMと8nMのIC50でAkt1、Akt2とAkt3を目標としている非常に選択的な汎Akt阻害剤です。

  • GSK690693

    GSK690693は、Akt1、Akt2とAkt3を目標としている汎Akt阻害剤で、IC50 がそれぞれ 2 nM、13 nM、9 nMです。

  • Perifosine (KRX-0401)

    Perifosine (KRX-0401)は、4.7 nMのIC50による新しいAkt阻害剤です。

  • A-674563

    A-674563は、Akt1 抑制影響を示しまして、Ki が 11 nMです。

    Features:Orally bioavailable compound (achieved by replacing indole of A-443654 with phenyl moiety) and somewhat less selective for Akt over PKA than A-443654.

最近チェックしたアイテム

Tags: MK-2206 2HClを買う | MK-2206 2HCl供給者 | MK-2206 2HClを購入する | MK-2206 2HCl費用 | MK-2206 2HCl生産者 | オーダーMK-2206 2HCl | MK-2206 2HCl代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ