MK-2206 2HCl

MK-2206 2HCl は一種の高選択性のAkt1/2/3阻害剤で、無細胞試験でIC50値が8 nM/12 nM/65 nMそれぞれに分かれて、250種類他のタンパク質キナーゼに抑制活性を表しません。臨床2期。

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MK-2206 2HCl 化学構造
分子量: 480.39

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MSDS

製品説明

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    Akt製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MK-2206 2HCl は一種の高選択性のAkt1/2/3阻害剤で、無細胞試験でIC50値が8 nM/12 nM/65 nMそれぞれに分かれて、250種類他のタンパク質キナーゼに抑制活性を表しません。臨床2期。
ターゲット Akt1 Akt2 Akt3
IC50 8 nM 12 nM 65 nM [1]
In vitro試験 MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. [1] MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. [2] MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. However, eukaryotic elongation factor-2 (eEF-2) silencing suppresses MK-2206-induced-autophagy, with a promotion of apoptotic cell death. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NCI-H292 NFzlOZBEgXSxdH;4bYMhSXO|YYm= Mn:1N{DPxE1? NYPPTWJkPzJiaB?= NHjEe2hFVVOR NIPBbI9KdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbh?= MV6yNFU4OTB4OR?=
A431 MmPDT4lv[XOnIFHzd4F6 NFnyR2E2KM7:TR?= NEjmd2s2KGh? NGLwT25FVVOR NGG2SGdUfXCycnXzd4V{KHSqZTDzbYdv[Wyrbnegc4YhSWu2IHHu[EBGemt? MYKyNFU4OTB4OR?=
HepG2 NVHnTmF[S3m2b4TvfIlkKEG|c3H5 NGS4V4cyOCEQvF2= NYe1Rm9vOjRiaB?= MVHEUXNQ M4DqO3NmdnOrdHn6[ZMhemW|aYP0ZY51KGOnbHzzJJRwKHSqZTDjfZRwfG:6aXOg[YZn\WO2IH;mJJNwemGoZX7pZi=> NVTtT|l6OjF{MEW5NlU>
Sk-Hep1 NVy2flJyS3m2b4TvfIlkKEG|c3H5 M2Xz[|ExKM7:TR?= Ml\5NlQhcA>? MXTEUXNQ M2q5bnNmdnOrdHn6[ZMhemW|aYP0ZY51KGOnbHzzJJRwKHSqZTDjfZRwfG:6aXOg[YZn\WO2IH;mJJNwemGoZX7pZi=> MkP1NlEzODV7MkW=
OCUT1 cells harbored PIK3CA (H1047R+/+) NFPTXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrrTFk{KM7:TR?= MXK1JIQ> NETicY9FVVOR MornTWM2OD1yLkG0JO69VQ>? NVrt[GhLOjF{OEmyOlc>
K1 cells harbored PIK3CA (E542K+/+) MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj5eHc{KM7:TR?= NUHVbJdlPSCm M17vPGROW09? MUfJR|UxRTBwNUKg{txO Mof1NlEzQDl{Nke=
FTC133 cells harbored PTEN (allele deletion and R130+) MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVGzJO69VQ>? MnLQOUBl M{WwcWROW09? NFTkOoJKSzVyPUCuNVgh|ryP NF7kSlUzOTJ6OUK2Oy=>
C643 cells harbored HRAS (G13R+/−) M1\KRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj0[FVkOyEQvF2= MmG3OUBl M{Tac2ROW09? MUPJR|UxRTBwMkeg{txO M2q1WFIyOjh7Mk[3
Hth7 cells harbored NRAS (Q61R+/−) NXuxXWgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vGPFMh|ryP MkDZOUBl NILJXWhFVVOR M4S3TWlEPTB;ND61JO69VQ>? MoDWNlEzQDl{Nke=
TPC1 cells harbored RET/PTC1 rearrangement NXfCT4NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPKN{DPxE1? NFjqfJI2KGR? M{Pm[2ROW09? MmjJTWM2OD1yLkW5JO69VQ>? MWOyNVI5QTJ4Nx?=
Hth74 MlmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn21N{DPxE1? MUW1JIQ> M1TN[2ROW09? MoLBTWM2OD1{LkG5JO69VQ>? MYCyNVI5QTJ4Nx?=
KAT18 NF3LUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm4[nU{KM7:TR?= MUW1JIQ> MoLzSG1UVw>? NWHmNYdwUUN3ME20MlYzKM7:TR?= MYOyNVI5QTJ4Nx?=
SW1736 MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPrdZYyODBizszN NHexXYs2KGR? M{\YR2ROW09? MoGxTWM2OD12Nz61OkDPxE1? NXPTb|NMOjF{OEmyOlc>
WRO NXPGV5V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWSzUWNpOTByMDFOwG0> NFi1WlY2KGR? NYL4flY1TE2VTx?= NX;GO4ZEUUN3ME6xNFAxKM7:TR?= NIqwWm0zOTJ6OUK2Oy=>
TAD2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3WTFYyODByIN88US=> MmeyOUBl MWfEUXNQ NXXhbVFOUUN3ME6xNFAxKM7:TR?= MlfoNlEzQDl{Nke=
LN229 NFXOcYxCeG:ydH;zbZMhSXO|YYm= NIDzVpAxNjVizszN NY\jblk1PjBiaB?= M4nROWROW09? M4jWUmF2\22nboTzJIFxd3C2b3flcolkKGWoZnXjeJMhd2ZiZ3XmbZRqdmmk M13KcFIzODV5OUG0
T98G NUK0TYt5SXCxcITvd4l{KEG|c3H5 NE\PZXExNjVizszN M{\kd|YxKGh? NUK0TZk4TE2VTx?= NYWwZllSSXWpbXXueJMh[XCxcITv[4VvcWNiZX\m[YN1eyCxZjDn[YZqfGmwaXK= MV6yNlA2PzlzNB?=
HC11 MXnGeY5kfGmxbjDBd5NigQ>? MW[xNEDPxE1? NUTMUWFbOjRiaB?= MVfEUXNQ NULvbYdZUW6qaXLpeJMh|rJvY3Hz[YlvKGGwZDDBSHJRKHO7boTo[ZNqew>? M4TwV|IzPDJ4NkKx
MOLT-4 NWezUGhbS3m2b4TvfIlkKEG|c3H5 MXuxNEDPxE1? NIW0N|M1QCCq MVjEUXNQ NXLsblQzUUN3ME2xMlfjiIoQvF2= Mm[xNlI3OTR{NEO=
CEM-R M4n6TGN6fG:2b4jpZ{BCe3OjeR?= Ml;JNVAh|ryP MYW0PEBp MlPTSG1UVw>? MWjJR|UxRTNwM,MAje69VQ>? NUPqeGtLOjJ4MUSyOFM>
CEM-S M1T5[GN6fG:2b4jpZ{BCe3OjeR?= MWqxNEDPxE1? M1nOWlQ5KGh? NYrKXpY6TE2VTx?= NWrQRpl2UUN3ME21MlHjiIoQvF2= MYmyNlYyPDJ2Mx?=
MOLT-4 M1nrfGZ2dmO2aX;uJGF{e2G7 NWHwUG5zOTBizszN MlLnNlQhcA>? M{[zTGROW09? Mm\MRoxw[2u|IHPlcIx{KGmwIITo[UBIOC:JMTDwbIF{\SCxZjD0bIUh[2WubDDjfYNt\Q>? NXzVeWpiOjJ4MUSyOFM>
MOLT-4 MVPGeY5kfGmxbjDBd5NigQ>? M37uVVTjiIoQvF2= MXG0JIg> M3TEUWROW09? NXnDOmhMUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|NCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ MVGyNlYyPDJ2Mx?=
CEM-R M4TKZmZ2dmO2aX;uJGF{e2G7 NW\pe41EPOLCid88US=> NX;u[3pJPCCq MVXEUXNQ NVLnfIZQUW6lcnXhd4V{KHSqZTDhcY92dnRib3[gZ4xm[X[nZDDMR|RCN0JuIHGge4VtdC2nc4ThZoxqe2inZDDheZRweGijZ4mgcYFzc2W{ NI\qSpYzOjZzNEK0Ny=>
CEM-S M1vEV2Z2dmO2aX;uJGF{e2G7 M3f3XFTjiIoQvF2= NFLiRlE1KGh? NW\OZ3c1TE2VTx?= M{jXc2lv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFO1RU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? NVnBOWtSOjJ4MUSyOFM>
HepG2 cell NVvUbGFjU2mwYYPlJGF{e2G7 MWOyNEDPxE1? NF62TWczPCCq Ml30SG1UVw>? NGm2XnNFd3ewcnXneYxifGW|IITo[UBxcG:|cHjvdplt[XSrb36gc4YhSUuW M{fnOlI{Pzl5M{G5
HepG2 cell M2fucmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnGb|g{OCEQvF2= M1z4V|I1KGh? MlnLSG1UVw>? MmXhTY5pcWKrdIOgZ4VtdCCpcn;3eIg> Ml7BNlM4QTd|MUm=
HepG2 cell NXzlXmE5SXCxcITvd4l{KEG|c3H5 M{P4SlIxKM7:TR?= MX[yOEBp M{Xs[GROW09? NFi2O4lKdmS3Y3XzJINmdGxiYYDvdJRwe2m| NUXEZlM4OjN5OUezNVk>
GEO M4\RTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3VOVAxKG6P M4P3W|czKGh? M3OyfGROW09? M{jINWlvcGmkaYTzJINmdGxiZ4Lve5Rp NV;UVlY2OjR3OEGyN|E>
CNE-1 MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPJZYM{OTBizszN Mn3qPVYhcA>? NX;pN|ZiTE2VTx?= MWfJR|UxRTJwOU[g{txO NUX2VJVNOjV|M{[5NlU>
CNE-2 NEHibnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qxe|ExKM7:TR?= NEDpdI06PiCq MmnFSG1UVw>? NGS0XFFKSzVyPUSuOVMh|ryP NXjTd49YOjV|M{[5NlU>
HONE-1 NHLzPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNEDPxE1? MW[5OkBp MnziSG1UVw>? NHzR[WRKSzVyPUOuN|ch|ryP MXWyOVM{Pjl{NR?=
SUNE-1 MoD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOxNEDPxE1? MX25OkBp MmHySG1UVw>? NUS0UJozUUN3ME2wMlUzKM7:TR?= NHT5dIMzPTN|NkmyOS=>
CNE-2 M{jyXGZ2dmO2aX;uJGF{e2G7 M{W2dFExKM7:TR?= MUm0PEBp MYTEUXNQ MWXJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy M4XSblI2OzN4OUK1
HONE-1 Mk\FSpVv[3Srb36gRZN{[Xl? M3H6TVExKM7:TR?= Mn\oOFghcA>? NVXTW4NKTE2VTx?= MUDJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy MWWyOVM{Pjl{NR?=
NEC8 M3fEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi3U4x2UUN3ME2wMlA6PjVzIN88US=> NXrlNYw{W0GQR1XS
P12-ICHIKAWA M{jrbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PmcmlEPTB;MD6xNVYzKM7:TR?= MmXKV2FPT0WU
MDA-MB-175-VII MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG3TWM2OD1yLkGzO|M5KM7:TR?= NYLqcYl7W0GQR1XS
AsPC-1 MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH5TWM2OD1yLkKyNVIzKM7:TR?= NX\Ye|BIW0GQR1XS
T47D MoTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHq[3VKSzVyPUCuNlgzPSEQvF2= NUnDRWhpW0GQR1XS
HH NVL2VXkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnSZ|gyUUN3ME2wMlMxOjh|IN88US=> MkKyV2FPT0WU
MOLT-16 MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHGTWM2OD1yLkOwN|Ih|ryP MmTDV2FPT0WU
ES5 M1vHSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLnOmxbUUN3ME2wMlM1PDV3IN88US=> M3y1XHNCVkeHUh?=
RS4-11 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwM{S2NUDPxE1? M4ezfHNCVkeHUh?=
KARPAS-45 Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwM{ezNlEh|ryP Mn3VV2FPT0WU
NCI-H720 NGrj[HNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwM{e2O|kh|ryP MXrTRW5ITVJ?
H9 NYHORZhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrS[HJKSzVyPUCuN|g5QDNizszN NFTPV3hUSU6JRWK=
EFM-19 M3LZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPMTWM2OD1yLkS0NFEh|ryP NWXSd5Z[W0GQR1XS
SBC-1 M1LUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fCOGlEPTB;MD60OFA{PSEQvF2= M4f1[nNCVkeHUh?=
A4-Fuk MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTOZoFmUUN3ME2wMlQ3QDZ6IN88US=> NVzBZ4tkW0GQR1XS
NCI-H1563 Ml7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLtRXRQUUN3ME2wMlQ5OTh7IN88US=> NGqyVI1USU6JRWK=
HCC1419 NFnRWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwNEi4PVIh|ryP Mlq4V2FPT0WU
H-EMC-SS NWDBSFl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnrV|ZKSzVyPUCuOFk6OzlizszN M2DM[nNCVkeHUh?=
BHT-101 MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDJTWM2OD1yLkWyPVYyKM7:TR?= MVnTRW5ITVJ?
IGROV-1 M{ftRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HJNWlEPTB;MD61OVI1QSEQvF2= NXX3fmtTW0GQR1XS
HGC-27 NUD4S2JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwNU[3PFMh|ryP MWnTRW5ITVJ?
MDA-MB-361 MoniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT6NoJoUUN3ME2wMlU4PzZzIN88US=> M2C2OHNCVkeHUh?=
KE-37 Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNUiyOkDPxE1? MWnTRW5ITVJ?
HCC70 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwNUm4Nlch|ryP MoTXV2FPT0WU
LNCaP-Clone-FGC M{fUSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnLUlhKSzVyPUCuOlExPDhizszN NGm4T3JUSU6JRWK=
HAL-01 MoHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXl[HdqUUN3ME2wMlYzOTNizszN MUfTRW5ITVJ?
HT NHzXb5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnkWo9KSzVyPUCuOlMzOzlizszN NGDQfFFUSU6JRWK=
MDA-MB-415 M3P1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3u[FZKSzVyPUCuOlM3OjZizszN NFS3PJVUSU6JRWK=
NOS-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorDTWM2OD1yLk[zO|I{KM7:TR?= NELKZWdUSU6JRWK=
DU-145 MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTYTWM2OD1yLk[0O|Q2KM7:TR?= M1jZbXNCVkeHUh?=
OCUB-M NUjUO3lQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLOS5NjUUN3ME2wMlcxQTZ4IN88US=> NGD4WmJUSU6JRWK=
VA-ES-BJ M3PlSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjLdY5KSzVyPUCuO|MxOjVizszN NF7IbYNUSU6JRWK=
J-RT3-T3-5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwN{S0NFMh|ryP MYjTRW5ITVJ?
MOLT-4 M2TNUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXuTWM2OD1yLkiwOVgzKM7:TR?= MkCzV2FPT0WU
NB7 M136OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXlS4JKSzVyPUCuPFI1OTFizszN MULTRW5ITVJ?
L-363 MnjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXnTWM2OD1yLkizOFQzKM7:TR?= MX7TRW5ITVJ?
NKM-1 NGL5SJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rLbGlEPTB;MD64OlI2OyEQvF2= NVXOcHBnW0GQR1XS
HOP-92 NVT4XoR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jNVWlEPTB;MD64O|IzOyEQvF2= NGHKenlUSU6JRWK=
OAW-42 NXPwdnpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm2TWM2OD1yLki4O|Ih|ryP NFTwPG9USU6JRWK=
HuO9 NFm4XWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXRdGVKSzVyPUCuPVI4PTFizszN NGfSWGNUSU6JRWK=
MFE-280 M1ezbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fTXGlEPTB;MD65OlQ3PSEQvF2= NH7yTY1USU6JRWK=
EM-2 NVy3TI5pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwOUe5N|kh|ryP NWX5e5p4W0GQR1XS
NCI-H520 MkDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DLZmlEPTB;MD65PFU6OiEQvF2= NH;KOJlUSU6JRWK=
LB2241-RCC NEWxXWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\pOGlEPTB;MD65PVc{PCEQvF2= MYDTRW5ITVJ?
SK-NEP-1 NGDPbo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFmzbFBKSzVyPUGuNVQ1QDVizszN MnLBV2FPT0WU
LXF-289 M3HwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;SWWdKSzVyPUGuNVcyPTZizszN NEjLeVhUSU6JRWK=
EPLC-272H MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\kUWJyUUN3ME2xMlE4OjV4IN88US=> MXXTRW5ITVJ?
COLO-684 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XJcWlEPTB;MT6yN|czPSEQvF2= NIDnPIdUSU6JRWK=
ES1 NVzVcopiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFwMkSwOlUh|ryP M{jIbHNCVkeHUh?=
DOHH-2 M1jub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17RWWlEPTB;MT6yPFIxOyEQvF2= MV;TRW5ITVJ?
CTB-1 Mon6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTFwMki5PUDPxE1? NVfLSW1LW0GQR1XS
G-401 NHLNTo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFwMkm3PVUh|ryP MlKzV2FPT0WU
LoVo NFeybI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3S[5VKSzVyPUGuN|I2OzRizszN MoXWV2FPT0WU
Ramos-2G6-4C10 NVnCXVBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LibmlEPTB;MT6zN|cxOSEQvF2= NXvWcFdGW0GQR1XS
MFM-223 M4T2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTFwM{S0OlEh|ryP Ml7VV2FPT0WU
PA-1 M{DUPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nDTmlEPTB;MT6zOVI3PSEQvF2= MXvTRW5ITVJ?
697 MlTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj6ZXBKSzVyPUGuN|c3OTZizszN NE[wTYVUSU6JRWK=
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HCC1954 NYHuZ3dLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHSeWJ1UUN3ME24MlQ2OTB2IN88US=> Ml;PV2FPT0WU
SF126 NI\3XVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PyTWlEPTB;OD60OVk{PiEQvF2= NXfvOVJwW0GQR1XS
LB996-RCC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXrdYdnUUN3ME24MlU{OjV5IN88US=> MlXoV2FPT0WU
SKG-IIIa M3TOXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRThwNkOwOlkh|ryP MXfTRW5ITVJ?
NCI-SNU-1 NEX0b3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRThwNkS2OFMh|ryP NHfzU5dUSU6JRWK=
LB771-HNC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTYTWM2OD16Lk[0Olk3KM7:TR?= Mn7pV2FPT0WU
SCC-4 NIfUfVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV6zWJNsUUN3ME24MlY5OjF7IN88US=> M{XKXXNCVkeHUh?=
CAMA-1 NXftcXl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRThwN{exOFYh|ryP MXnTRW5ITVJ?
D-502MG MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\rfIFKSzVyPUiuO|g3OjlizszN M3jjU3NCVkeHUh?=
ESS-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M32yUWlEPTB;OD64PFcxPCEQvF2= MUPTRW5ITVJ?
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8505C Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPITWM2OD17LkC0NlMzKM7:TR?= Ml;JV2FPT0WU
EFO-27 NIXiXHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTlwMU[0NVIh|ryP M1vib3NCVkeHUh?=
HN NG\mVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDZXVRKSzVyPUmuNVY3OjhizszN M1\xNXNCVkeHUh?=
DSH1 MlPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fqWmlEPTB;OT6yNFg4KM7:TR?= NY\FcHFpW0GQR1XS
NBsusSR NHvRO3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:5UmlEPTB;OT6yO|QxOiEQvF2= NHO5e5ZUSU6JRWK=
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SHP-77 NHvEdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTlwM{m5N|Uh|ryP MWnTRW5ITVJ?
ACN M33GXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTlwNUOyO|ch|ryP MWPTRW5ITVJ?
U251 MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIi3Z|lKSzVyPUmuOlU2PDRizszN NGrWVXhUSU6JRWK=
A431 M4jXR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzmVJFKSzVyPUmuPFAzOzhizszN M3XFWHNCVkeHUh?=
5637 M3jCfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu1WZY3UUN3ME25Mlg1QTh2IN88US=> MlvPV2FPT0WU
MDA-MB-157 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvrTWM2OD17LkmyPFc5KM7:TR?= MXvTRW5ITVJ?
A101D MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTlwOUm5O|Qh|ryP MXLTRW5ITVJ?
YKG-1 M1SzVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M172RmlEPTB;MUCuNlAxPiEQvF2= NFvVeIJUSU6JRWK=
LAN-6 NUGwVHZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXezW|lSUUN3ME2xNE4zOTZ2IN88US=> MVvTRW5ITVJ?
OVCAR-5 Mmn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rwdWlEPTB;MUCuNlQ{OyEQvF2= MW\TRW5ITVJ?
A549 NGOzTlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTFyLkO5O|Mh|ryP MmHQV2FPT0WU
no-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D3OWlEPTB;MUCuOFM2OyEQvF2= M4X0UHNCVkeHUh?=
SF539 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTFyLkmwOFEh|ryP MYLTRW5ITVJ?
A388 NFPNUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFzLkO4PVch|ryP NFGxXWVUSU6JRWK=
DEL M1;UNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\NSYM{UUN3ME2xNU41OjRizszN MUXTRW5ITVJ?
SW954 NGLQd5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTFzLkS2Olgh|ryP NY\YXItxW0GQR1XS
TK10 NVPGbJV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPCd45RUUN3ME2xNU42OjdzIN88US=> MXjTRW5ITVJ?
SW756 M{jsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T3NWlEPTB;MUGuOVI6PCEQvF2= MYnTRW5ITVJ?
PC-3 NISzbVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTFzLkW3OlQh|ryP M4D3ZXNCVkeHUh?=
ONS-76 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnoTWM2OD1zMT62N|Yh|ryP NIXjNYtUSU6JRWK=
A427 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v4dmlEPTB;MUGuO|A6OyEQvF2= M{TBfXNCVkeHUh?=
MEG-01 M{n3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XuZWlEPTB;MUGuO|UxQSEQvF2= NX[xWmU1W0GQR1XS
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NCI-H1299 MonGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XiVWlEPTB;MUGuPFA6OyEQvF2= Mlq3V2FPT0WU
GCT MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4L6dWlEPTB;MUGuPFIzQCEQvF2= Ml3nV2FPT0WU
D-247MG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETuNGxKSzVyPUGxMlk3PjNizszN NXj0cXJpW0GQR1XS
CFPAC-1 M2XLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfXdlJSUUN3ME2xNU46Pzh{IN88US=> NFT1OVlUSU6JRWK=
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CAL-51 MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlruTWM2OD1zMj6wO|E3KM7:TR?= Mn;TV2FPT0WU
BB49-HNC NV\0XlIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrUTJBOUUN3ME2xNk4yOTd5IN88US=> NWnyVJpVW0GQR1XS
RPMI-7951 NUHsdo4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrvTWM2OD1zMj6xPFU1KM7:TR?= M2LIT3NCVkeHUh?=
RH-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDidZJqUUN3ME2xNk4zOTh2IN88US=> MWPTRW5ITVJ?
BCPAP NITUNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS0TWM2OD1zMj60O|Q6KM7:TR?= NXzZZWhwW0GQR1XS
GCIY NVWw[np{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF{LkWyNFkh|ryP NFzHXldUSU6JRWK=
KNS-81-FD MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:5[WlRUUN3ME2xNk42QDZ7IN88US=> MoThV2FPT0WU
KYSE-140 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTMTWM2OD1zMj64OVk2KM7:TR?= Mmq1V2FPT0WU
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HCC1187 M3LCRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m3OmlEPTB;MUOuNVkyOiEQvF2= NXLFOHl3W0GQR1XS
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WM-115 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfvS|NEUUN3ME2xN{43PDh|IN88US=> NXi0VY5xW0GQR1XS
CHP-212 M{jwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTF|Lkm3N|kh|ryP MknMV2FPT0WU
SCC-15 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfTTWM2OD1zMz65O|c2KM7:TR?= MVLTRW5ITVJ?
BPH-1 M{HJUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTk[mJrUUN3ME2xOE4yPjZ2IN88US=> Mof0V2FPT0WU
SW780 NGfDNFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\VTWM2OD1zND61NFI2KM7:TR?= M4HJcXNCVkeHUh?=
NCI-H2291 NGHncJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlSzTWM2OD1zND61PFc5KM7:TR?= NVv4fXFVW0GQR1XS
JEG-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTF2Lk[zNlYh|ryP MUnTRW5ITVJ?
CAL-120 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrmTWRKSzVyPUG0MlcxOjdizszN MUjTRW5ITVJ?
NCI-H23 MnjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnXTWM2OD1zND63PVk4KM7:TR?= M3m3cHNCVkeHUh?=
MS-1 NIP1dnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\qbno1UUN3ME2xOE46PjFzIN88US=> NHX0b4VUSU6JRWK=
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D-283MED M37OTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LJT2lEPTB;MUWuNFEyOSEQvF2= Mn;kV2FPT0WU
OE19 NEfuU4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfXTWM2OD1zNT6xOVQyKM7:TR?= MlHEV2FPT0WU
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NCI-H727 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTF3LkSyNlEh|ryP NHnwPGlUSU6JRWK=
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BFTC-905 NEDkWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrxToh7UUN3ME2xOU44Pjl2IN88US=> M33NdnNCVkeHUh?=
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KYSE-270 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm3eIlpUUN3ME2yNE4xOjF5IN88US=> MmP2V2FPT0WU
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NCI-H1355 M{LMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJyLkOzO|Qh|ryP Mn7WV2FPT0WU
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NCI-H2122 MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHniWmJKSzVyPUKyMlI1OzJizszN MkfNV2FPT0WU
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DoTc2-4510 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zWXWlEPTB;OESuNlE5PSEQvF2= MVHTRW5ITVJ?
NCI-H1581 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTtTWM2OD16NT60OlQyKM7:TR?= NYfn[2dwW0GQR1XS
KARPAS-299 MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XQeGlEPTB;OE[uNVk4PyEQvF2= M2P6WXNCVkeHUh?=
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KP-N-YS MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\FdWlEPTB;OEmuPVAzQCEQvF2= NI\kfGdUSU6JRWK=
KYSE-410 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvlTWM2OD17MT60NFQzKM7:TR?= Mk\OV2FPT0WU
TE-10 MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH0TWM2OD17MT61OlEyKM7:TR?= M13Ke3NCVkeHUh?=
SK-MEL-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojwTWM2OD17Mj65NVA3KM7:TR?= M1nQWHNCVkeHUh?=
COLO-792 MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjzWXdKSzVyPUm1MlI2PjRizszN Mn;IV2FPT0WU
SCH MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\MZWlEPTB;OU[uN|g4PyEQvF2= Mo\pV2FPT0WU
NCI-H1792 MmntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLyTWM2OD17Nj64PVkzKM7:TR?= NX3EO3Z1W0GQR1XS
NCI-H2029 MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3KzSWlEPTB;OU[uPVU3PiEQvF2= Mn;vV2FPT0WU
SW684 NEHzUnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnsSJNKSzVyPUm4MlY3PTRizszN NYrNXVJIW0GQR1XS
NCI-H209 NVrHflVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2SxdGlEPTB;MUCwMlEzOSEQvF2= MoLIV2FPT0WU
HLE NUjhXWpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDqXGhwUUN3ME2xNFUvOjh{IN88US=> MoLnV2FPT0WU
GOTO Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjsTWM2OD1zMEeuO|c4KM7:TR?= M3G2[HNCVkeHUh?=
NCI-H1793 M4O5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFyOT6yPEDPxE1? M1LFRnNCVkeHUh?=
D-392MG NXi4SFJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHaTWM2OD1zMUeuN|k5KM7:TR?= NWC1doE5W0GQR1XS
SW1990 NFLIOIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jaTmlEPTB;MUKwMlk2OSEQvF2= M{OyN3NCVkeHUh?=
ML-2 M2K2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTPTWM2OD1zMkGuOlc3KM7:TR?= NYrPd4lRW0GQR1XS
NCI-H2452 MmPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7VeW5jUUN3ME2xNlIvOjFizszN NWrvOWhuW0GQR1XS
SK-MEL-30 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTF{Mz6yOFQh|ryP MVjTRW5ITVJ?
SN12C M3rXN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjCPGViUUN3ME2xNlQvOTd4IN88US=> NHmwUohUSU6JRWK=
NCI-H1770 Ml;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPOTWM2OD1zMkWuOVE1KM7:TR?= NYfyW2t{W0GQR1XS
SF268 MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTF{Nj6xOVgh|ryP MmjaV2FPT0WU
BALL-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKy[VNMUUN3ME2xNlYvOjNizszN M2exfnNCVkeHUh?=
COLO-679 MoL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTLOVJKSzVyPUGyOk44PTNizszN M{j0RXNCVkeHUh?=
A2780 NUi1TY9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rMdGlEPTB;MUK4Mlk5QCEQvF2= MUnTRW5ITVJ?
NCI-H1651 M{W4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13oV2lEPTB;MUOxMlI1OyEQvF2= M4e4PHNCVkeHUh?=
NCI-H2087 NYj3coV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7nZZRKSzVyPUGzNU41QDNizszN MmXQV2FPT0WU
U-87-MG NULKPHZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPKbXlKSzVyPUGzN{43ODRizszN NETJ[5JUSU6JRWK=
LB2518-MEL MkX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX2zdGZQUUN3ME2xN|UvQTl|IN88US=> MYPTRW5ITVJ?
HCT-116 M1zBNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jEXGlEPTB;MUO3MlIyPyEQvF2= NGLUPJFUSU6JRWK=
Ca9-22 M{fsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fjeGlEPTB;MUO5Mlg{OyEQvF2= NWHXeYV5W0GQR1XS
COR-L88 NWDRSGp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIq4VpVKSzVyPUG0Nk4yPCEQvF2= NHTwNXRUSU6JRWK=
CP50-MEL-B NEDCTXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXF[YxzUUN3ME2xOFQvPTBzIN88US=> MULTRW5ITVJ?
OVCAR-8 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HpfGlEPTB;MUS1MlY{PiEQvF2= MV7TRW5ITVJ?
SK-MEL-3 NXHHZZVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13vTWlEPTB;MUS3Mlg4QCEQvF2= MmTBV2FPT0WU
GT3TKB MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPuNW1KSzVyPUG0PU46OjhizszN NWG3[ZBOW0GQR1XS
KYSE-450 NH[1XGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrHTWM2OD1zNUGuOVM6KM7:TR?= M1naWXNCVkeHUh?=
CAPAN-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTF3Mz6wOlQh|ryP MYHTRW5ITVJ?
BEN M{mzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPvbGxKSzVyPUG1N{46OjhizszN MVvTRW5ITVJ?
NCI-H1304 NWn1Opc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnkXXk5UUN3ME2xOVQvPjl2IN88US=> NEnTTo9USU6JRWK=
KU812 M{nteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGn1S4RKSzVyPUG1PE43PzRizszN MYXTRW5ITVJ?
Capan-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:xTWM2OD1zNkCuOVU{KM7:TR?= MYHTRW5ITVJ?
A673 MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm4dJpKSzVyPUG2NU44ODVizszN MnzmV2FPT0WU
SAS MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LxZ2lEPTB;MU[yMlY4QCEQvF2= MWXTRW5ITVJ?
NY M2rMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjJTWM2OD1zNkWuN|E1KM7:TR?= MmjHV2FPT0WU
HCE-4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTF4Nj64OFUh|ryP MkTBV2FPT0WU
MDA-MB-231 MnjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\hNGpwUUN3ME2xO|cvPTB|IN88US=> MonMV2FPT0WU
no-10 NF\5[2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvjTWM2OD1zN{iuNVM1KM7:TR?= NXrvUVFQW0GQR1XS
MZ7-mel NWfQVZdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[4O|hKSzVyPUG3PE41PjdizszN MYnTRW5ITVJ?
NCI-H82 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PUOWlEPTB;MUiwMlE3PSEQvF2= NGrIdWFUSU6JRWK=
CAL-72 NX\6N3c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTF6NT6wOVQh|ryP NIjXfoFUSU6JRWK=
NCI-SNU-5 MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnuPVFKSzVyPUG4Ok45PCEQvF2= MUXTRW5ITVJ?
OVCAR-4 NYS1doxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLUTWM2OD1zOEiuN|M{KM7:TR?= NVXOXGFsW0GQR1XS
SCC-9 NHfCOWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTF7MTFOwG0> NEj1SpZUSU6JRWK=
KYSE-150 M1y4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrzTWM2OD1zOUGuPFg5KM7:TR?= MUfTRW5ITVJ?
HT-29 M1[2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXKR2RWUUN3ME2yNFEvOjF{IN88US=> M13nSHNCVkeHUh?=
COLO-678 NEDJenhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3LRZlKSzVyPUKwNU41PSEQvF2= M3y4OHNCVkeHUh?=
NCI-H650 NXu5[XBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfiZo1KSzVyPUKwNk4yODNizszN NF7GOnBUSU6JRWK=
HuCCT1 NFvtU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfn[XdJUUN3ME2yNFQvOjB6IN88US=> MWPTRW5ITVJ?
SW1116 NWTlNJdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTzU|VTUUN3ME2yNFcvODd5IN88US=> NXPzbmxzW0GQR1XS
DBTRG-05MG MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJyNz65NFkh|ryP M2njb3NCVkeHUh?=
SW982 NH21UXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPq[YJKSzVyPUKwO{46PDhizszN NVvwU|R3W0GQR1XS
RCM-1 NGHnN4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn2WmFKSzVyPUKxOE44PjJizszN MnLrV2FPT0WU
COLO-320-HSR NEHONlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\xTWM2OD1{MU[uNVI2KM7:TR?= M1jyb3NCVkeHUh?=
KNS-42 M2n0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDoc3dKSzVyPUKxOk42PzRizszN MXrTRW5ITVJ?
C2BBe1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzrN2JsUUN3ME2yN|EvQTB3IN88US=> MkjOV2FPT0WU
CCRF-CEM Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYeycHFYUUN3ME2yOFMvPzl3IN88US=> NYnafG17W0GQR1XS
SH-4 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XnUGlEPTB;MkS2MlA6KM7:TR?= M2qyOXNCVkeHUh?=
LS-1034 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrOcFhKSzVyPUK0Ok4zPjZizszN NYrDT3l3W0GQR1XS
NCI-H2347 M3K2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHrTWM2OD1{NEeuO|E{KM7:TR?= MoLzV2FPT0WU
RPMI-8866 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ2OT6yO{DPxE1? NYPqdXVNW0GQR1XS
GAK M3XwcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJ3Mz6wNFIh|ryP MXHTRW5ITVJ?
NB6 NH7RSFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nFPWlEPTB;MkewMlEh|ryP NV\3bYc2W0GQR1XS
COLO-680N M3n0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfUZotKSzVyPUK3Nk42OjdizszN M37tS3NCVkeHUh?=
RERF-LC-MS M17ZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJ5Nj6wNFch|ryP MlOwV2FPT0WU
TGBC11TKB M3rDSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJ5OD6xO|gh|ryP M3jrVXNCVkeHUh?=
C8166 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDPO4xKSzVyPUK3PE42ODZizszN NI\iSoxUSU6JRWK=
HDLM-2 Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK5TWM2OD1{OUSuOFA6KM7:TR?= M4L5NXNCVkeHUh?=
IGR-1 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHGOpdKSzVyPUK5OU43PTlizszN NUTPclFSW0GQR1XS
FADU Mn;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LmZ2lEPTB;Mkm3MlUyKM7:TR?= M1TMcnNCVkeHUh?=
L-428 NEPOZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTJ7Nz62NVYh|ryP MWHTRW5ITVJ?
LU-65 NILyVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTNyND6zNkDPxE1? Mn;5V2FPT0WU
HEL NX;XUJlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLqTWM2OD1|MEmuPVg{KM7:TR?= M37McnNCVkeHUh?=
NCI-H810 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PDd2lEPTB;M{GwMlU4KM7:TR?= MYHTRW5ITVJ?
C3A NIHUS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rGR2lEPTB;M{GxMlgxOiEQvF2= M4HFe3NCVkeHUh?=
NCI-H630 NHrtXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTN|Mj6yPVQh|ryP MkTwV2FPT0WU
KP-N-YN MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnXdI9KSzVyPUO0NU4yOjNizszN MV;TRW5ITVJ?
MOLT-13 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4P3[2lEPTB;M{SyMlMzPiEQvF2= MnSwV2FPT0WU
NCI-H1993 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTN2Mj6zOlUh|ryP MoL0V2FPT0WU
BE-13 M3jzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO3UHFKSzVyPUO0OE4yPjdizszN NVq1bm9vW0GQR1XS
IST-SL1 NXzhRZp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXEelRqUUN3ME2zOFcvPDBzIN88US=> NWHoXoRGW0GQR1XS
TE-9 NIDkOpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPzTHlKSzVyPUO2N{42QDlizszN Mm\YV2FPT0WU
LU-135 MnL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTN4Nz6wN|Uh|ryP M{DERnNCVkeHUh?=
T84 NI[0Ro1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTrTWM2OD1|N{SuO|EzKM7:TR?= NX;lb49MW0GQR1XS
K-562 M4D4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrJVWtKSzVyPUO4N{4{PiEQvF2= MXrTRW5ITVJ?
SBC-5 Mmj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrtO|JKSzVyPUO4Ok46QDVizszN M2\vdXNCVkeHUh?=
NB17 NWr6cVE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzlXnpKSzVyPUO5Nk42QTZizszN MUHTRW5ITVJ?
NCI-H2052 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;4VWhKSzVyPUO5PE41PzJizszN NID5[WpUSU6JRWK=
HCC38 NFzC[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfGTWM2OD12MEGuOVk{KM7:TR?= MVrTRW5ITVJ?
NCI-H69 NEW0epJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG1d2NwUUN3ME20OFEvODh|IN88US=> NIDYRWtUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 MK-2206 shows 60% TGI and inhibits more than 70 % of phospho-Akt1/2 (T308 and S473) in A2780 ovarian cancer xenografts at a dose of 240 mg/kg. [1] MK-2206 exhibits significant antitumor activity in NCI-H292 xenograft in combination with erlotinib or lapatinib. [2]
臨床試験 MK-2206 is currently under Phase II clinical trial for treatment of ovarian cancer, primary peritoneal cancer and fallopian tube cancer.
特集 The first allosteric small molecule inhibitor of Akt to enter clinical development.

プロトコル (参考用のみ)

キナーゼアッセイ: [4]

Akt kinases assay Akt kinases are assayed by a GSK-derived biotinylated peptide substrate. The extent of peptide phosphorylation is determined by Homogeneous Time Resolved Fluorescence (HTRF) using a lanthanide chelate (Lance)-coupled monoclonal antibody specific for the phosphopeptide in combination with a streptavidin-linked allophycocyanin (SA-APC) fluorophore which will bind to the biotin moiety on the peptide. When the Lance and APC are in proximity, a non-radiative energy transfer takes place from the Lance to the APC, followed by emission of light from APC at 655 nm. Working Solution: 100X protease inhibitor cocktail (PIC): 1mg/mL benzamidine, 0.5 mg/mL pepstatin, 0.5 mg/mL leupeptin, 0.5 mg/mL aprotinin; 10X assay buffer: 500 mM HEPES, pH7.5, 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-glycerol phosphate; Quench buffer 50 mM HEPES pH 7.3, 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM labeled monoclonal antibody, 0.0067 mg/mL SA-APC; ATP/MgCl2 working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, active Akt; Peptide working solution: 1X Assay buffer, 1 mM DTT, 1X PIC, 5% glycerol, 2 TM GSK biotinylated peptide. The reaction is assembled by adding 16 µL of ATP/MgCl2 working solution to the appropriate wells. MK-2206 or vehicle (1.0 µL) is added followed by 10 µL of peptide working solution. The reaction is started by adding 13 μL of the enzyme working solution and mixing. The reaction is allowed to proceed for 50 min and then stopped by the addition of 60 µL HTRF quench buffer. The stopped reactions are incubated at room temperature for at least 30 min and then read in the instrument.

細胞アッセイ: [2]

細胞株 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells
濃度 0, 0.3, 1 and 3 μM
反応時間 72 or 96 hours
実験の流れ MK-2206 is dissolved in DMSO as a stock solution and diluted by culture media before use. Cells are seeded at a density of 2-3 × 103 in 96-well plates and incubated for 24 hours. Then MK-2206 (0, 0.3, 1 and 3 μM) is added to the cells. Cell proliferation is determined after 72 or 96 hours.

動物実験: [2]

動物モデル SK-OV-3, NCI-H292, HCC70, PC-3, and NCI-H460 models in male CD1-nude mice
製剤 Formulated in 30% Captisol
投薬量 120 mg/kg
投与方法 Orally administered

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MK-2206 2HCl SDF
分子量 480.39
化学式

C25H21N5O.2HCl

CAS No. 1032350-13-2
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

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Frequently Asked Questions

  • Question 1
    I would want to know if MK-2206 could cross the blood brain barrier?

    Answer: MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

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