MG-132 化学構造
分子量: 475.62

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製品説明

  • Compare Proteasome Inhibitors
    Proteasome製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MG-132は、100nMのIC50によるプロテアソームの強力な阻害剤です。
ターゲット

Proteasome

IC50

100 nM [1]

In vitro試験 MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
LPS-stimulated RAW264.7 cells NXzhR|M5TnWwY4Tpc44hSXO|YYm= MYWyOUDPxE1? MV;EUXNQ NVrnOnJzUW6qaXLpeJMhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDBwMTFOwG0> MoL3NlQ3QTd2OU[=
HL-60 MlTxR5l1d3SxeHnjJGF{e2G7 MYK0NEDPxE1? MlWwOFghcA>? NV7ydYI{TE2VTx?= NYPS[olUUUN3MEyxNEDPxE1? M{C4SlI1Pjl5NEm2
SMMC-7721 NG\0No9EgXSxdH;4bYMhSXO|YYm= NF;ybpo1OCEQvF2= NUPT[2p6PDhiaB?= M2HOW2ROW09? M4jad2lEPTB;Nz6xJO69VQ>? MkflNlQ3QTd2OU[=
A-549 NES3XYJEgXSxdH;4bYMhSXO|YYm= NWfje25VPDBizszN MX:0PEBp MYnEUXNQ MXzJR|UxRDFyIN88US=> M1jrc|I1Pjl5NEm2
MCF-7 M1;3OWN6fG:2b4jpZ{BCe3OjeR?= Mlf5OFAh|ryP NX[0TWlHPDhiaB?= MkPZSG1UVw>? NH7GdYxKSzVyPUeuN{DPxE1? MWWyOFY6PzR7Nh?=
SW-480 M{nEb2N6fG:2b4jpZ{BCe3OjeR?= MmnyOFAh|ryP MYW0PEBp NFflPGZFVVOR MWnJR|UxRTRizszN NFvpXWIzPDZ7N{S5Oi=>
NCI-H929 MljIR5l1d3SxeHnjJGF{e2G7 MVWxJO69VQ>? NHTlOlk4OiCq M1K3ZWROW09? MVHJR|UxRTBwMUeg{txO MVKyOFYzPTB6OB?=
293T M2qxfGN6fG:2b4jpZ{BCe3OjeR?= NFu5fI4yOCEQvF2= NV3YdJlGPzJiaB?= NXXnRYtmTE2VTx?= NEHlXVRKSzVyPEKg{txO MmS3NlQ3OjVyOEi=
293T M4HQfWZ2dmO2aX;uJGF{e2G7 NFrFNWwyOCEQvF2= NXjVfYdWOjRiaB?= MUHEUXNQ MXrNc4RmemG2ZXz5JIlv\HWlZYOgbIVifC2|aH;jb{Ah M3;GZlI1PjJ3MEi4
HeLa MkP2T4lv[XOnIFHzd4F6 NHrYem0yOCEQvF2= NVrBUXg{OSCq M1;nR2ROW09? Ml3WTY5lfWOnczDQRXJRKGOuZXH2ZYdmKGK7IHnubIljcXSrbnegdJJwe2Wjc3;t[UBi[3Srdnn0fS=> MkDWNlQ{OjF6M{O=
MDA-MB-231 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrieotkOSEQvF2= MXG3NkBp NYXJSmdsTE2VTx?= M4DTPWlEPTB;MD6xPEDPxE1? NX;SdFZbOjRzNUOyNFY>
MCF-7 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTzUXgyKM7:TR?= NHjHNHQ4OiCq NY\jdZVOTE2VTx?= MYXJR|UxRTBwMUOg{txO NFTxN4szPDF3M{KwOi=>
MCF10A MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3Z[WVOOSEQvF2= MVO3NkBp NYPLUlc3TE2VTx?= NETOcYRKSzVyPUCuNlkh|ryP NWnmUY5EOjRzNUOyNFY>
HEK-293 M3:xZmtqdmG|ZTDBd5NigQ>? NFHEVlUzKGGwZDCyNEDPxE1? MXiyJIg> M4jGWWROW09? MmTZTY5pcWKrdIOgR4hVNUxiYXP0bZZqfHlid3n0bEBKSzVyIH;mJFkhdk1i NHvKWZczOzV2MEe5NC=>
Calu6 NUXJOHNRTnWwY4Tpc44hSXO|YYm= NFracHMyOCEQvF2= MXixPEBp MYDEUXNQ MUnTbYdvcW[rY3HueIx6KGGlY4XteYxifGW|IH\yZZRigGmwIIDy[YN2enOxch?= MoLzNlM2ODZ2OE[=
IFN-gamma-induced RAW264.7 MoHuSpVv[3Srb36gRZN{[Xl? NIC3T5dFVVOR M4TuTWlvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjB5NzFOwG0> NXXhWZp[OjJ{N{eyO|c>
IPC227F NYTrN2tuS3m2b4TvfIlkKEG|c3H5 NILuSYUyKM7:TR?= M2LYU|Q5KGh? NE[2[XFFVVOR NYSwNlh4UUN3ME2wMlA4PyEQvF2= NXHjXZVZOjF7MkS1Nlg>
Hepa-1c1c7 NFnZd|BHfW6ldHnvckBCe3OjeR?= NGD0NHAzPSEQvF2= NF7ZdVQ3KGh? NETBSXpFVVOR M1zyPWlv[3KnYYPld{BPemZ{IIDyc5RmcW5ibHX2[Yw> NYfRVo9LOjB|OUK1OFQ>
COS-7 NVfiVoV5S3m2b4TvfIlkKEG|c3H5 MV:xNEDPxE1? MU\EUXNQ NUS5[GREUUN3MEyxNEDPxE1? NUT0[lk5OThyOEiwPVc>
HuH-7 MWHDfZRwfG:6aXOgRZN{[Xl? M4S4O|ExKM7:TR?= NYH4XXBzTE2VTx?= M1PyPGlEPTB:MUCg{txO NFX4NlUyQDB6OEC5Oy=>
OCI-Ly3 M{TtSGZ2dmO2aX;uJGF{e2G7 MWCxNEDPxE4EoB?= M1vzOlQhcA>? MVXEUXNQ NYW1[4lUUW6mdXPld{BpfW2jbjDJb4FxeGGEYXzwbIEhe3SjYnnsbZpifGmxbjD3bZRpKEWFNUCgc4YhOSEQvF2= MXuxPFAzPDFzMx?=
A2780 cDDP NXLXNVV{SXCxcITvd4l{KEG|c3H5 NIf5cm8zPCCq MV\EUXNQ NVi0WnB[UW6mdXPld{BieG:ydH;zbZMh[nliaX7obYJqfGmwZzDQWGVPKGSnZ4Lh[IF1cW:w MXyxO|Y5PDBzOB?=
LPS-stimulated RAW264.7 cells NWC4[VFpTnWwY4Tpc44hSXO|YYm= NYnDe21[TE2VTx?= MW\Jcohq[mm2czDOSk1s[XCyYVKgSG5CKGKrbnTpcoc> MW[xO|QxPzJ5Nx?=
PC12 NWrJU5NnTnWwY4Tpc44hSXO|YYm= M{O1bVExOCEQvF5CpC=> NXTh[WNnOjRiaB?= NFzCfHRFVVOR NIDNd5RKdmirYnn0d{A3NU:KRFGtJIFv\CCKMl:yMYlv\HWlZXSgZ5l1d3SxeHnjbZR6 NVTzTnllOTdzNUi0OVQ>
PC3 NGrXPFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHkfFUzOCEQvF2= Ml3COFghcA>? MoruSG1UVw>? NYLzTo9qUUN3ME2wMlYh|ryP MnHlNVY3QDZ3M{e=
LP-1 MmLVRZBweHSxc3nzJGF{e2G7 NHXvbnk{ODBibl2= M3WwSVI1KGh? Mon6SG1UVw>? MXvJcoR2[2W|IHHwc5B1d3OrczDifUBqdmO{ZXHzbY5oKGOuZXH2[YQhWEGUUDDs[ZZmdCCjbnSgdoVlfWOrbnegUYNtNTFicILveIVqdiCuZY\lcC=> MmLoNVU6PTh3OEm=
ES6 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrrZ45KSzVyPUCuNFE{ODZizszN NHn4NnpUSU6JRWK=
A101D NIj6NmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGKxO4FKSzVyPUCuNFMzPzlizszN NF3kWmhUSU6JRWK=
OCUB-M MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHwOGZJUUN3ME2wMlA{PzN5IN88US=> NHPkcZNUSU6JRWK=
LB2518-MEL M2O1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEO3OkDPxE1? NETxOWhUSU6JRWK=
SH-4 NXzzT|VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPodYtKSzVyPUCuNFQ{OSEQvF2= NYKyOZhIW0GQR1XS
KNS-42 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTuW|lXUUN3ME2wMlA1PDRzIN88US=> MYrTRW5ITVJ?
DSH1 M3vYVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXmwUVY3UUN3ME2wMlA2Ojh7IN88US=> NUPCeGNyW0GQR1XS
NTERA-S-cl-D1 NXPvbpQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\wfFh5UUN3ME2wMlA2Pzd{IN88US=> NIT6e|VUSU6JRWK=
D-542MG M2DRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEW5OVch|ryP MV7TRW5ITVJ?
KS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXueIpKSzVyPUCuNFY1PThizszN NIDheGxUSU6JRWK=
BL-41 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwME[5OFch|ryP MWfTRW5ITVJ?
LXF-289 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvkb4NKSzVyPUCuNFcxPjZizszN M1;QS3NCVkeHUh?=
D-247MG M3rrU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mof4TWM2OD1yLkC3NlA6KM7:TR?= M3fSTHNCVkeHUh?=
MMAC-SF NHjKT5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\vZ|h[UUN3ME2wMlA4OjZ6IN88US=> MoPuV2FPT0WU
CP66-MEL NHfncFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHzTmdYUUN3ME2wMlA4PSEQvF2= MYHTRW5ITVJ?
LB771-HNC M{\ReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLNTWM2OD1yLkC4NFM3KM7:TR?= NUPUTZRoW0GQR1XS
no-10 NFjE[WJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLjTWM2OD1yLkC4PVA6KM7:TR?= NULpR4V6W0GQR1XS
A388 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TBZmlEPTB;MD6wPVA3PSEQvF2= NUPLeldyW0GQR1XS
OPM-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnznTWM2OD1yLkGwOFc1KM7:TR?= NFjxR29USU6JRWK=
OVCAR-4 Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMUC5N|gh|ryP MUnTRW5ITVJ?
HOP-62 MnvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33kNGlEPTB;MD6xNFk1QSEQvF2= NVP1dIpxW0GQR1XS
ML-2 NITHNJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PIO2lEPTB;MD6xNVgxPiEQvF2= NELLU|hUSU6JRWK=
UACC-257 M{XkSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMUG5Nlch|ryP M2\X[HNCVkeHUh?=
NEC8 MmPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L3PWlEPTB;MD6xNVk6PSEQvF2= NWHYO2p{W0GQR1XS
ONS-76 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn2wTWM2OD1yLkGyPVM2KM7:TR?= M17Pe3NCVkeHUh?=
KE-37 NXyzbnlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMUOyO|gh|ryP MkX2V2FPT0WU
HT-144 M4TjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke5TWM2OD1yLkGzPFk2KM7:TR?= NXH6e2NbW0GQR1XS
LB2241-RCC MnnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\WdWlEPTB;MD6xOFI1PyEQvF2= NFy0UFBUSU6JRWK=
TE-5 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHJS4ZsUUN3ME2wMlE1Ojd6IN88US=> MofsV2FPT0WU
KINGS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fXd2lEPTB;MD6xOFc6KM7:TR?= M1z1fXNCVkeHUh?=
NCI-H69 NIr1TW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjFN41RUUN3ME2wMlE2OTRzIN88US=> MXjTRW5ITVJ?
CAS-1 M4H3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMUW0PFIh|ryP NHrlXo1USU6JRWK=
D-263MG NYLCeIQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37YTmlEPTB;MD6xOlAxPiEQvF2= NEHNN4VUSU6JRWK=
A253 NHjO[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HCPWlEPTB;MD6xOlEzQCEQvF2= NETVUYRUSU6JRWK=
PF-382 NEjkT5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\nRVltUUN3ME2wMlE3PzB4IN88US=> NXuwPXRbW0GQR1XS
CESS M3K2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y0VGlEPTB;MD6xO|A3KM7:TR?= NXKyZW9CW0GQR1XS
MZ2-MEL NVvoSG9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vRSmlEPTB;MD6xO|U2QSEQvF2= MlizV2FPT0WU
HEL M2HGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljTTWM2OD1yLkG4OVE4KM7:TR?= M3T5N3NCVkeHUh?=
D-392MG M4XZPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMUmxNVUh|ryP M2PZPHNCVkeHUh?=
SK-LMS-1 NIixUlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fDfmlEPTB;MD6xPVMxOyEQvF2= NUTObVdqW0GQR1XS
GI-ME-N MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qwUGlEPTB;MD6xPVMxPiEQvF2= NULVc5BlW0GQR1XS
LB831-BLC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXBRlg4UUN3ME2wMlE6OzRizszN MWjTRW5ITVJ?
DU-4475 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMUm2OVgh|ryP MVTTRW5ITVJ?
IST-SL1 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr1WIY3UUN3ME2wMlIxODl2IN88US=> MW\TRW5ITVJ?
GAK MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjGPFVKSzVyPUCuNlA2OzRizszN MkjUV2FPT0WU
EW-1 NIL4d|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMkGwOFch|ryP NI\XTmpUSU6JRWK=
LAMA-84 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMkG4OVEh|ryP M2robXNCVkeHUh?=
SK-UT-1 NIq3VldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHuxO4RKSzVyPUCuNlIxPDlizszN MWXTRW5ITVJ?
VA-ES-BJ NFXhR2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMkKyOVch|ryP M1vSWnNCVkeHUh?=
ACN M4PiU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfQdlFpUUN3ME2wMlIzPjN6IN88US=> NXjiXmhLW0GQR1XS
SK-PN-DW NUfMVFE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMkOxPUDPxE1? M1v1RXNCVkeHUh?=
HD-MY-Z NHzRd2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMkOzNFMh|ryP MWXTRW5ITVJ?
LB373-MEL-D NUGxc5JpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF75ZZJKSzVyPUCuNlQyQThizszN NVnSTJlbW0GQR1XS
COLO-829 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPvTWM2OD1yLkK0NlU4KM7:TR?= MXXTRW5ITVJ?
ES8 NUXneIVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXFfndKSzVyPUCuNlQ4PjNizszN NE\Vc4JUSU6JRWK=
RXF393 M2jkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLTTWM2OD1yLkK1NFE2KM7:TR?= M1jTNHNCVkeHUh?=
TK10 Mo[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjKPW9KSzVyPUCuNlU1OzVizszN MXjTRW5ITVJ?
LOUCY NIjDW|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHuWItKSzVyPUCuNlU1PTZizszN M{fk[nNCVkeHUh?=
MZ7-mel MnLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moe2TWM2OD1yLkK2N|c1KM7:TR?= NGLpNHNUSU6JRWK=
CP67-MEL NXHycWUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMk[3N{DPxE1? M2fi[nNCVkeHUh?=
C2BBe1 NULJWWJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\KboNKSzVyPUCuNlc6ODdizszN NUHxSYhjW0GQR1XS
K052 MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjrTWM2OD1yLkK4PVkh|ryP NETNNXBUSU6JRWK=
MOLT-16 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DK[GlEPTB;MD6yPVUzPCEQvF2= NWrYRVdbW0GQR1XS
KNS-81-FD NYL2e3R2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHzXnVKSzVyPUCuN|A{OjNizszN MYfTRW5ITVJ?
CMK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD5V|dKSzVyPUCuN|EyOiEQvF2= MXnTRW5ITVJ?
LAN-6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHL0ZlJKSzVyPUCuN|E{KM7:TR?= Mmj3V2FPT0WU
KLE NFm1d2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jseGlEPTB;MD6zNVMxPiEQvF2= MoPmV2FPT0WU
NCCIT NVvWSVRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zITmlEPTB;MD6zNVc5OyEQvF2= MXPTRW5ITVJ?
HH NXe1XXlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T5U2lEPTB;MD6zNlg6PyEQvF2= MULTRW5ITVJ?
TE-8 NXm3VllxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3juRWlEPTB;MD6zOFI4QSEQvF2= M3jmZXNCVkeHUh?=
GDM-1 NXLqPHdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvPTWM2OD1yLkO1NVA1KM7:TR?= NHTVO5JUSU6JRWK=
NCI-H747 M2\iXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fiS2lEPTB;MD6zO|ExOyEQvF2= Ml\jV2FPT0WU
NCI-H1092 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETKOYdKSzVyPUCuN|g5PDRizszN M1TmWXNCVkeHUh?=
8-MG-BA MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO2TWM2OD1yLkO5PFM4KM7:TR?= M1f1fXNCVkeHUh?=
NB17 NILMWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjXSZc1UUN3ME2wMlQzQTdizszN MnLlV2FPT0WU
LC4-1 NUj2emVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG2eWRuUUN3ME2wMlQ{PjB5IN88US=> MV3TRW5ITVJ?
TE-1 M17RbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPsOo9uUUN3ME2wMlQ2OTF7IN88US=> NH\SVpNUSU6JRWK=
KALS-1 NWL4bIdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;2S2lEPTB;MD60OlU5PCEQvF2= M365WXNCVkeHUh?=
CCRF-CEM NILlZnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXSS4h2UUN3ME2wMlQ4Pjd2IN88US=> MUTTRW5ITVJ?
OS-RC-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHL6NmRKSzVyPUCuOFc6PzJizszN MVTTRW5ITVJ?
A704 M1TqfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\zTWM2OD1yLkS4OlkzKM7:TR?= MWfTRW5ITVJ?
BB49-HNC NXPqfHZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwNEmwPVYh|ryP NYXjVmVlW0GQR1XS
EVSA-T M3jCVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf0dm5KSzVyPUCuOFk6OTFizszN MXPTRW5ITVJ?
Mo-T M1fEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwNUG3OlIh|ryP MVPTRW5ITVJ?
MONO-MAC-6 NH\OcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[5TWM2OD1yLkWzOlEyKM7:TR?= M4nxU3NCVkeHUh?=
BB65-RCC Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDPOIhTUUN3ME2wMlU3QDFzIN88US=> MX;TRW5ITVJ?
NCI-H1882 M{\3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{naR2lEPTB;MD61PVA{PiEQvF2= NGPybnhUSU6JRWK=
TE-9 NEHHR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwNkGwN|Mh|ryP M1ToTnNCVkeHUh?=
NCI-H2126 NEC0c|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfuTWM2OD1yLk[yOlY6KM7:TR?= NYC2WnFtW0GQR1XS
SF268 M2TwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwNkW2OFEh|ryP Mn7vV2FPT0WU
SW872 NWm0UW5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTRe40xUUN3ME2wMlY2PzJ7IN88US=> NVXvcIpsW0GQR1XS
LS-513 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwNk[3OVEh|ryP NIDN[ZNUSU6JRWK=
NCI-H1355 NX7UeFJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vjVmlEPTB;MD62PFYyQSEQvF2= M4\MUHNCVkeHUh?=
BL-70 M3TnVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD0N2JwUUN3ME2wMlY6Ozh6IN88US=> NHK0NJFUSU6JRWK=
NCI-SNU-5 M1XTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLK[ZFwUUN3ME2wMlY6PTR3IN88US=> NFHvU5FUSU6JRWK=
SNU-C2B NGTySItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq4TWM2OD1yLkewO|M6KM7:TR?= NGfCUWZUSU6JRWK=
GB-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHxUIpKSzVyPUCuO|IyOjRizszN M2LXXHNCVkeHUh?=
CTB-1 MoDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwN{e5OVUh|ryP NE\yc4xUSU6JRWK=
Becker NI\DcJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfyTWM2OD1yLke5OlIyKM7:TR?= MXvTRW5ITVJ?
KM12 NU\nV4xkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjTNmVKSzVyPUCuPFU1PjZizszN NWHxdHg5W0GQR1XS
ES7 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LxR2lEPTB;MD64PVY2KM7:TR?= MoTnV2FPT0WU
COLO-684 M175SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHqcWlKSzVyPUCuPVA3PThizszN NGfMeXFUSU6JRWK=
HCC2998 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4D1emlEPTB;MD65N|g2PCEQvF2= M4O4RXNCVkeHUh?=
TE-10 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwOU[0N{DPxE1? NYPnWWI6W0GQR1XS
SF126 NVrHRoZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O3dmlEPTB;MD65PFk4OSEQvF2= NFHZVohUSU6JRWK=
EKVX Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknNTWM2OD1zLkCzOFQzKM7:TR?= M2foN3NCVkeHUh?=
KARPAS-45 MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX1WpZKSzVyPUGuNFQxOTZizszN NULQbJh4W0GQR1XS
KGN MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHjcZNKSzVyPUGuNFUxPDVizszN MluwV2FPT0WU
ES1 NULMZpRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEiwS5RKSzVyPUGuNFc6OjFizszN NHrUVGhUSU6JRWK=
L-540 MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnCOIJKSzVyPUGuNVE5OzlizszN MX\TRW5ITVJ?
KURAMOCHI NVjob|lET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLpTWM2OD1zLkGyN|c1KM7:TR?= M{LhcHNCVkeHUh?=
LU-65 NGi4eFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rUdWlEPTB;MT6xNlc2OyEQvF2= M1nwXXNCVkeHUh?=
MFH-ino NF6wSGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33QPWlEPTB;MT6xO|UxOSEQvF2= NUjKNol2W0GQR1XS
NCI-H23 M2j3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nXc2lEPTB;MT6yNFQyKM7:TR?= NWnO[GpHW0GQR1XS
IA-LM M17ScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLreHFVUUN3ME2xMlI1OTF4IN88US=> MlzyV2FPT0WU
PSN1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXNTWM2OD1zLkK3NFE3KM7:TR?= MlvYV2FPT0WU
NCI-H719 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTFwMke0NVEh|ryP NY\EdY52W0GQR1XS
SW684 Mn;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFwMki2OVkh|ryP M{XQcHNCVkeHUh?=
HCE-4 NWCwV5NtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILHXoxKSzVyPUGuN|AzOjFizszN MVjTRW5ITVJ?
EW-16 MkXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTPTWM2OD1zLkOxN|Q4KM7:TR?= NUjU[m81W0GQR1XS
NCI-H128 MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFwM{W4NVQh|ryP NXfmNWw5W0GQR1XS
HC-1 NELGN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TnR2lEPTB;MT6zPFE4KM7:TR?= NVnON4kyW0GQR1XS
IST-MES1 NVPkUGI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTFwNECyNFgh|ryP NYDaZZRJW0GQR1XS
Raji M1XMemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTFwNEG4OUDPxE1? M1WzZ3NCVkeHUh?=
DMS-114 NU\IbHM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTFwNES1N|kh|ryP MVrTRW5ITVJ?
GI-1 M2HxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DO[mlEPTB;MT60O|E{OSEQvF2= NYCxTnlqW0GQR1XS
NCI-H2081 NGDRRZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXhTWM2OD1zLkW1NVk3KM7:TR?= M3zOZnNCVkeHUh?=
LC-1F NI\Tb4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTFwNUWxPVgh|ryP NVi0cos1W0GQR1XS
NCI-H2227 NW\4WGtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHyTWM2OD1zLk[xOVYyKM7:TR?= NXvKVHc2W0GQR1XS
D-502MG M1f2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVG4fpFJUUN3ME2xMlY4OjFzIN88US=> MV7TRW5ITVJ?
NCI-H2141 M1P4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X4dWlEPTB;MT62O|MyPyEQvF2= NVnG[XptW0GQR1XS
LS-411N MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPEfpZKSzVyPUGuOlk5ODdizszN NFTvSnRUSU6JRWK=
SU-DHL-1 M1u5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLkVXpwUUN3ME2xMlcyOjhzIN88US=> NIDT[GZUSU6JRWK=
BB30-HNC MoPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnziTWM2OD1zLkeyOlg2KM7:TR?= NUW5PI1OW0GQR1XS
TE-15 NEnCOG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHwZohzUUN3ME2xMlkzOzd|IN88US=> M3P0[3NCVkeHUh?=
JVM-3 NXPDcopST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTFwOUO5NFQh|ryP NHXaTJFUSU6JRWK=
IST-SL2 NWDjN4dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfwTZRMUUN3ME2yMlAyOjV{IN88US=> MofSV2FPT0WU
EW-18 MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJwMEKzN|ch|ryP MULTRW5ITVJ?
DJM-1 M{HLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXxTWM2OD1{LkCyOVUzKM7:TR?= M3Hk[XNCVkeHUh?=
no-11 Mn\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXroRmgyUUN3ME2yMlA{OTB2IN88US=> MlnDV2FPT0WU
QIMR-WIL MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrTd4hPUUN3ME2yMlE3PzZ{IN88US=> NWDyeZc3W0GQR1XS
MC-CAR NHjoc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPrUoxvUUN3ME2yMlIzQTVizszN NFTocZdUSU6JRWK=
KM-H2 NYW2fmJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XOdGlEPTB;Mj6yPVA1OyEQvF2= NFPneohUSU6JRWK=
ECC12 Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXadnZCUUN3ME2yMlM4QTRizszN MnzEV2FPT0WU
HCE-T MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTBW4tKSzVyPUKuOFQ5QDNizszN M37DWHNCVkeHUh?=
MFM-223 MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jxZ2lEPTB;Mj61NFg4OSEQvF2= MX;TRW5ITVJ?
SW982 MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LYNmlEPTB;Mj61NVQ5KM7:TR?= M3vEdXNCVkeHUh?=
KG-1 M1O5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPyW|N3UUN3ME2yMlg5PzlzIN88US=> M{PQPHNCVkeHUh?=
ES4 M4LjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37scmlEPTB;Mz6wOlEyOSEQvF2= M3eyZXNCVkeHUh?=
SCC-3 NF3uPGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTNwMUC4OFgh|ryP NXrMbmhWW0GQR1XS
RH-1 NFu4XGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlK4TWM2OD1|LkO4O|Q5KM7:TR?= NFK1[|FUSU6JRWK=
NCI-H748 MnSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH2TWM2OD1|LkS0NlY3KM7:TR?= MVrTRW5ITVJ?
HCC2218 NGW2cW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLCeVk3UUN3ME2zMlQ3QTN5IN88US=> MkKyV2FPT0WU
MEG-01 M3fKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFX2fYNKSzVyPUOuOVk3QCEQvF2= NIL2fm1USU6JRWK=
NB12 M4HSXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DJeWlEPTB;Mz61PVg5QCEQvF2= MXLTRW5ITVJ?
SNB75 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDrWZVrUUN3ME2zMlYxOTB|IN88US=> MljHV2FPT0WU
KMS-12-PE M2LjR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXmTWM2OD1|Lk[3O|I{KM7:TR?= Mn;1V2FPT0WU
SKM-1 MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTNwN{GzO|Yh|ryP M2DWSnNCVkeHUh?=
COLO-320-HSR MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTNwN{W2N|Qh|ryP NVLjN3g2W0GQR1XS
NKM-1 NH;uXHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTNwN{ezO|gh|ryP MWDTRW5ITVJ?
TE-6 NXfvVYozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M122dGlEPTB;Mz65OFU3OSEQvF2= MoXwV2FPT0WU
D-336MG MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rYRWlEPTB;ND6wNVE3PiEQvF2= M4D6OnNCVkeHUh?=
NCI-H1650 MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzN[HZKSzVyPUSuNVU4QTdizszN M1S2[3NCVkeHUh?=
ES3 NF;kUY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrKcZZYUUN3ME20MlMzQDJ2IN88US=> MoLqV2FPT0WU
YT M3zrVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTRwM{W0NlQh|ryP NXjBUG5rW0GQR1XS
ES5 M1qzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHtNHpKSzVyPUSuOFAzPTVizszN M{[4fHNCVkeHUh?=
LB647-SCLC MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG4TWM2OD12LkW2N|A5KM7:TR?= NFTKNlRUSU6JRWK=
HAL-01 Mn7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LnTmlEPTB;ND61O|A{PCEQvF2= NFPJdnZUSU6JRWK=
LP-1 MoTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XtfGlEPTB;ND63NlM4OSEQvF2= MXvTRW5ITVJ?
BC-1 NEjOW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NED2TJdKSzVyPUWuNFA1PDdizszN NV;jTYhDW0GQR1XS
EB-3 M17oTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny3TWM2OD13LkCzNFQyKM7:TR?= Mmm0V2FPT0WU
GT3TKB MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTVwMUe2OlIh|ryP NHrZcnZUSU6JRWK=
NCI-H209 NXrZR3dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHQVGtUUUN3ME21MlE6OzV{IN88US=> MXLTRW5ITVJ?
BT-474 MmnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTCOI51UUN3ME21MlI{OTB{IN88US=> NEH3N2RUSU6JRWK=
RKO MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT4boFKSzVyPUWuNlM1OjJizszN MkTJV2FPT0WU
SIMA MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTvOlhLUUN3ME21MlMxPzZ3IN88US=> NXfXSlc{W0GQR1XS
RL Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTVwM{e1OFEh|ryP M2HadnNCVkeHUh?=
GCIY M1nrV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonZTWM2OD13LkS3NlM3KM7:TR?= NI\TRYZUSU6JRWK=
Calu-6 MlXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHC[IJKSzVyPUWuOlIzKM7:TR?= NFnqV2NUSU6JRWK=
ALL-PO M1PYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fOS2lEPTB;NT62N|c6PSEQvF2= MU\TRW5ITVJ?
ARH-77 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXS0ZW8zUUN3ME21MlY4ODh5IN88US=> NXu2bGFvW0GQR1XS
A4-Fuk MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTZwMEixNVgh|ryP NX\BeFBjW0GQR1XS
NCI-H1581 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3mzN2lEPTB;Nj6yN|g1QSEQvF2= M1;uRnNCVkeHUh?=
HUTU-80 MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTZwM{[4PVch|ryP MYjTRW5ITVJ?
TGW MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTZwNEW1PVMh|ryP Mo\uV2FPT0WU
SK-N-FI M2HBcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf5eHJHUUN3ME22MlQ2QDV2IN88US=> MVXTRW5ITVJ?
U-266 NXTVT|BjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xn[GlEPTB;Nj61NVkzPiEQvF2= M3;2WXNCVkeHUh?=
EM-2 M4\SWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfvTWM2OD14Lk[3NFk6KM7:TR?= M1uxSXNCVkeHUh?=
NMC-G1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\uVWlKSzVyPU[uO|E5QTVizszN NVTTeVkxW0GQR1XS
KASUMI-1 MlPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPzXZZoUUN3ME22Mlg1Pzh5IN88US=> M2rFUnNCVkeHUh?=
NALM-6 NGrE[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPVfmc{UUN3ME22Mlg3PzV2IN88US=> NGXOZWJUSU6JRWK=
OCI-AML2 M33n[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL3[3dKSzVyPUeuNFA{OjZizszN NHjOXJVUSU6JRWK=
SHP-77 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fyRmlEPTB;Nz6yNlQ{KM7:TR?= NXPHRYhNW0GQR1XS
NOMO-1 NIrEWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTdwMkSyOVQh|ryP M1vGZ3NCVkeHUh?=
SK-N-DZ Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofhTWM2OD15LkexNFg6KM7:TR?= MlnZV2FPT0WU
LB1047-RCC NWnCXWJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP5cGpKSzVyPUeuO|IzOzFizszN NXjHfWhXW0GQR1XS
MZ1-PC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjBSYk3UUN3ME23Mlg3PTV6IN88US=> NInEcFBUSU6JRWK=
NB10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTdwOUm1OVYh|ryP M3fkSXNCVkeHUh?=
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SIG-M5 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjWTWM2OD1|MD63PVUzKM7:TR?= MW\TRW5ITVJ?
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NCI-H1694 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHsTWM2OD15MT6wN|Ih|ryP NFjYXZFUSU6JRWK=
NCI-H82 M2TIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTdzLkm1NFch|ryP NHXMelNUSU6JRWK=
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HCC1599 M{D0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrSTWM2OD15ND64O|MzKM7:TR?= MUnTRW5ITVJ?
NCI-H1155 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\iT5A2UUN3ME23OE46OzZ5IN88US=> NVHk[oNHW0GQR1XS
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HCC1187 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTd5Lk[xNlIh|ryP NYDCVnNPW0GQR1XS
NCI-H322M NYLMZWkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTd6LkO3NFkh|ryP NXHP[G1JW0GQR1XS
NCI-H526 NGe2NmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTd6LkW4O|ch|ryP M1zOO3NCVkeHUh?=
NCI-H2171 NVXsNYpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTd7LkSxN|Yh|ryP NFTEcYhUSU6JRWK=
COLO-668 M{K4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfC[oNKSzVyPUixMlU5QDRizszN MXXTRW5ITVJ?
RS4-11 NYPpOodHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTh{LkK1NFUh|ryP Mo\YV2FPT0WU
NCI-H716 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17mOmlEPTB;OEKuPVA4PSEQvF2= M1\PPXNCVkeHUh?=
LU-134-A Mm\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vXWWlEPTB;OEOuNVM2OSEQvF2= MkTvV2FPT0WU
RPMI-8226 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn6TWM2OD16ND6yNVA4KM7:TR?= NY\rc5dlW0GQR1XS
KY821 M1LxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTlzLk[1OVEh|ryP NGfaeJNUSU6JRWK=
ECC4 MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK5TWM2OD17Mz64NlY6KM7:TR?= M4LZOHNCVkeHUh?=
EW-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDsVYpwUUN3ME25OE46ODhzIN88US=> MXLTRW5ITVJ?
NB7 NWLIXoVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M365TmlEPTB;OUWuO|c5PiEQvF2= MoH1V2FPT0WU
NCI-H720 NEnQenpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTl6LkSwOlEh|ryP MoXjV2FPT0WU
NCI-H446 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTl7Lke1PFgh|ryP NEXWU4tUSU6JRWK=
NCI-H889 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLjTWM2OD1zMESuNlQzKM7:TR?= MkfuV2FPT0WU
EW-22 Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHmzRo9KSzVyPUGwOk4yQSEQvF2= M{HUUnNCVkeHUh?=
BV-173 M4TqPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTvTWM2OD1zMEiuO|I5KM7:TR?= NIW1WmtUSU6JRWK=
WSU-NHL MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFyOT62O|Eh|ryP M2W5XXNCVkeHUh?=
MN-60 Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\jU5lKSzVyPUGwPU43QSEQvF2= MXPTRW5ITVJ?
DG-75 MljZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\OSYlKSzVyPUGxN{4{PTJizszN NWrle5pGW0GQR1XS
DMS-79 M{fBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnYcldKSzVyPUGxO{4{QDJizszN NGfkTlBUSU6JRWK=
SK-MEL-1 MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFzOD6wNFkh|ryP Mkn5V2FPT0WU
DMS-153 NUfZ[YlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGj3TWlKSzVyPUGyNU44PDVizszN MY\TRW5ITVJ?
NCI-H510A NES3RVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:3eoI3UUN3ME2xNlcvOzJizszN M3PwN3NCVkeHUh?=
BE-13 NGjuVI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTF|ND6wOFQh|ryP NEPFXlBUSU6JRWK=
KP-N-YS MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHlTWM2OD1zM{muO|M3KM7:TR?= M2jOSnNCVkeHUh?=
SUP-T1 M{\Vdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTF2Mz63NFgh|ryP MV7TRW5ITVJ?
EW-12 NVT6VVV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknzTWM2OD1zNESuOlk6KM7:TR?= NUHSNIN4W0GQR1XS
NB14 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTF2Nz6wPFIh|ryP NWDMemoyW0GQR1XS
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TUR M3\zR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTrcGxsUUN3ME2xOlcvQDdizszN MV\TRW5ITVJ?
NCI-H1417 NVLlOYIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTF6MD6zN|Eh|ryP M1e0THNCVkeHUh?=
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NCI-H226 NHXDcJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTrTnZKSzVyPUG4PE45PjZizszN M3fIWnNCVkeHUh?=
NCI-H187 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fOZWlEPTB;MUmwMlA3PCEQvF2= M1TEV3NCVkeHUh?=
SF539 MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF7Mj63Nlgh|ryP NHq3NHBUSU6JRWK=
TALL-1 NIDQcYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nRVWlEPTB;MUm4MlMxPCEQvF2= MVPTRW5ITVJ?
TE-441-T MkWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnYfVdKSzVyPUG5PU44OzlizszN NYfVToNXW0GQR1XS
REH NYPSV5BwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fwfGlEPTB;MkO2MlYzPiEQvF2= NEjRPGZUSU6JRWK=
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THP-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\KTWM2OD1{NkSuO|M5KM7:TR?= M3PKXXNCVkeHUh?=
NCI-H1838 NEm0SIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJ5MT60OVYh|ryP NYnzR|gzW0GQR1XS
P30-OHK MlTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTKTWM2OD1{OEOuPFQ4KM7:TR?= MnznV2FPT0WU
C8166 NELuWXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3YcVU{UUN3ME2zOFUvOzN6IN88US=> M{XwcnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Measurement of inhibitory activities of MG-132 against 20S proteasome The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.

細胞アッセイ:

[3]

細胞株 KIM-2, HC11, and ES
濃度 Dissolved in DMSO, final concentrations ~25 μM
反応時間 24, and 48 hours
実験の流れ

Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.

動物実験:

[7]

動物モデル Male mdx (C57BL/10ScSn DMD mdx) mice
製剤 Dissolved in DMSO, and diluted in PBS
投薬量 ~10 μg/kg/day
投与方法 Injection

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MG-132 SDF
分子量 475.62
化学式

C26H41N3O5

CAS No. 133407-82-6
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 95 mg/mL (199.73 mM)
エタノール 95 mg/mL (199.73 mM)
<1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate

カスタマーフィードバック (9)


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Rating
Source Nat Cell Biol, 2015, 17(1), 95-103. MG-132 purchased from Selleck
Method Immunoprecipitation
Cell Lines MDA-MB-231 cells
Concentrations 10 uM
Incubation Time 6 h
Results SIAH2 destabilizes LATS2 through proteasome. SIAH2-mediated LATS2 degradation was inhibited by proteasomal inhibitor MG132, but not by lysosomal inhibitor BA-1. The half-life of LATS2 was shortened by SIAH2.

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Rating
Source Nucleic Acids Res, 2014, 42(1), 458-74. MG-132 purchased from Selleck
Method Western blot
Cell Lines HeLa cells
Concentrations 20 uM
Incubation Time 8 h
Results As RMND5A downregulation resulted in a rapid decrease of protein Exportin-5, this effect was partially abolished by the proteasome inhibitor MG132, indicating that RMND5A protect Exportin-5 protein against proteasome degradation.

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Rating
Source Nucleic Acids Res, 2014, 42(1), 458-74. MG-132 purchased from Selleck
Method Immunocytochemistry
Cell Lines HeLa cells
Concentrations 20 uM
Incubation Time 8 h
Results It was surprised to observe that Exportin-5 retention in nucleus when its protein levels were downregulated by RMND5A siRNA or miR-138. The proteasome inhibitor MG132 could recover not only Exportin-5 protein levels but also its normal subcellular localization.

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Rating
Source EMBO Mol Med, 2013, 5, 397-412. MG-132 purchased from Selleck
Method Western Blot
Cell Lines MEF cells
Concentrations 30 uM
Incubation Time 6 h
Results Treatment of MEF with proteasome inhibitor MG132 resulted in similar increase of steady state levels of intracellular ATZ in both GFP- and TFEB- transfected Cells.

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Rating
Source Cell Rep, 2015, 11(9), 1458-73. MG-132 purchased from Selleck
Method Western Blot
Cell Lines A375, Lu1205 cells
Concentrations 5 uM
Incubation Time 10 h
Results MG132 treatment increased JAK1 steady-state levels, masking the effect of RNF125 depletion and partially blocking deregulated JAK1 expression by ectopically expressed RNF125.

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Source Plant Physiol, 2012, 60(1), 118-34. MG-132 purchased from Selleck
Method Immunoblot analysis
Cell Lines Arabidopsis thaliana
Concentrations 100 uM
Incubation Time 12 h
Results These rates of loss were markedly slower in the lrb1-1 lrb2-1 background. Importantly, phyB breakdown was also substantially attenuated upon exposing wild-type seedlings to the proteasome inhibitor MG132, thus implicating the 26S proteasome in particular. MG132 treatment also slightly stabilized phyB levels in lrb1-1 lrb2-1 seedlings, implying that other factors besides LRB1 and LRB2 might also direct phyB breakdown.

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Rating
Source Toxicol Appl Pharmacol, 2015, 286(2), 135-41. MG-132 purchased from Selleck
Method Immunofluorescence
Cell Lines γ-H2AX-stained cells
Concentrations 100 uM
Incubation Time 3 h
Results G2 cell cycle arrest usually reflects the formation of genomic damage in the preceding S-phase, which activates checkpoint response upon the entry of cells into G2 phase. Furthermore, MG132-treated cells also had larger amounts of γ-H2AX, as evidenced by the increased staining in individual nuclei .

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Rating
Source FEBS Lett, 2012, 586, 3787–3792. MG-132 purchased from Selleck
Method Western Blot
Cell Lines Hela cells
Concentrations
Incubation Time 12 h
Results When GSK-3 (Ser9) degradation was blocked by proteasome inhibitor (MG132), the increased amount of phosphorylated GSK-3 (Ser9) in responding to NOK was more clearly observed in the HeLa-NOK-HA cells (Fig. C).

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Rating
Source 2012, Dr. Edison DUKE-NUS Graduate Medical School Singapore.. MG-132 purchased from Selleck
Method Western blot
Cell Lines NIH3T3 cells
Concentrations 25 μM
Incubation Time 1-4 h
Results By adding MG132, a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment.

文献中の引用 (42)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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