MG-132 化学構造
分子量: 475.62

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製品説明

  • Compare Proteasome Inhibitors
    Proteasome製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MG-132は、100nMのIC50によるプロテアソームの強力な阻害剤です。
ターゲット

Proteasome

IC50

100 nM [1]

In vitro試験 MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
LPS-stimulated RAW264.7 cells MVfGeY5kfGmxbjDBd5NigQ>? MX[yOUDPxE1? NEnobZdFVVOR NFK3d4tKdmirYnn0d{BvcXS{aXOgc5hq\GVicILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOC5zIN88US=> NH\IXnkzPDZ7N{S5Oi=>
HL-60 NVric5llS3m2b4TvfIlkKEG|c3H5 M4j1TVQxKM7:TR?= NUXqb5dMPDhiaB?= NX7RUWNSTE2VTx?= MornTWM2ODxzMDFOwG0> NWXmR|JqOjR4OUe0PVY>
SMMC-7721 NV;KWWVNS3m2b4TvfIlkKEG|c3H5 M162RVQxKM7:TR?= MYm0PEBp NWLI[5dXTE2VTx?= NHjmdpVKSzVyPUeuNUDPxE1? NVj4eoJ{OjR4OUe0PVY>
A-549 NIL6TGZEgXSxdH;4bYMhSXO|YYm= MkexOFAh|ryP NWrQTllQPDhiaB?= MVvEUXNQ MofGTWM2ODxzMDFOwG0> NHf6cZMzPDZ7N{S5Oi=>
MCF-7 NHzU[pJEgXSxdH;4bYMhSXO|YYm= NVHndIRFPDBizszN MX60PEBp MlLUSG1UVw>? MmjTTWM2OD15LkOg{txO NIGy[3AzPDZ7N{S5Oi=>
SW-480 M4DkUWN6fG:2b4jpZ{BCe3OjeR?= NXPkcmV1PDBizszN MlzUOFghcA>? NYezblRtTE2VTx?= MW\JR|UxRTRizszN M2X6N|I1Pjl5NEm2
NCI-H929 M3Lyb2N6fG:2b4jpZ{BCe3OjeR?= NXzkV5Q6OSEQvF2= MlPnO|IhcA>? MYDEUXNQ NIjHWmtKSzVyPUCuNVch|ryP NH\PTIUzPDZ{NUC4PC=>
293T MnvnR5l1d3SxeHnjJGF{e2G7 MXGxNEDPxE1? MnrXO|IhcA>? MlvISG1UVw>? NVrzdWliUUN3MEyyJO69VQ>? MkjSNlQ3OjVyOEi=
293T MYDGeY5kfGmxbjDBd5NigQ>? MVSxNEDPxE1? MkDuNlQhcA>? MnTpSG1UVw>? M1S0cm1w\GW{YYTlcJkhcW6mdXPld{Bp\WG2LYPoc4NsKCB? MW[yOFYzPTB6OB?=
HeLa NWr0RllWU2mwYYPlJGF{e2G7 NH:2b4cyOCEQvF2= MnWxNUBp MX\EUXNQ MorJTY5lfWOnczDQRXJRKGOuZXH2ZYdmKGK7IHnubIljcXSrbnegdJJwe2Wjc3;t[UBi[3Srdnn0fS=> NWDp[IxIOjR|MkG4N|M>
MDA-MB-231 NF65SYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT6NUDPxE1? M33aUlczKGh? MVHEUXNQ MlnBTWM2OD1yLkG4JO69VQ>? NESxPVQzPDF3M{KwOi=>
MCF-7 NHrmUWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHzNUDPxE1? NF\vSpU4OiCq NYPUV2hDTE2VTx?= M{K5cGlEPTB;MD6xN{DPxE1? MU[yOFE2OzJyNh?=
MCF10A MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\kclgyKM7:TR?= NX\jRY13PzJiaB?= NFvsOWlFVVOR NEnpOVZKSzVyPUCuNlkh|ryP MWCyOFE2OzJyNh?=
HEK-293 NV\NW2drU2mwYYPlJGF{e2G7 MWSyJIFv\CB{MDFOwG0> NIfUcVYzKGh? M2LKfGROW09? MmXmTY5pcWKrdIOgR4hVNUxiYXP0bZZqfHlid3n0bEBKSzVyIH;mJFkhdk1i NXPpbnRNOjN3NEC3PVA>
Calu6 NY[3WFYyTnWwY4Tpc44hSXO|YYm= NYnhRXNoOTBizszN MnH5NVghcA>? NI\wclRFVVOR M3T5RnNq\26rZnnjZY51dHliYXPjeY12dGG2ZYOg[pJifGG6aX6gdJJm[3W{c3;y NVSxe4RVOjN3ME[0PFY>
IFN-gamma-induced RAW264.7 NHPncVNHfW6ldHnvckBCe3OjeR?= MoDYSG1UVw>? M1f4[mlvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjB5NzFOwG0> M{XLVFIzOjd5Mke3
IPC227F NYDGdpNHS3m2b4TvfIlkKEG|c3H5 M4nzTVEh|ryP NWrRUGNtPDhiaB?= MYXEUXNQ NGTTblhKSzVyPUCuNFc4KM7:TR?= M1fsc|IyQTJ2NUK4
Hepa-1c1c7 NUjSTo44TnWwY4Tpc44hSXO|YYm= M3:1bVI2KM7:TR?= MnvnOkBp NI[yfZVFVVOR MoD1TY5kemWjc3XzJG5z\jJicILveIVqdiCuZY\lcC=> Ml3WNlA{QTJ3NES=
COS-7 NVzyeFVrS3m2b4TvfIlkKEG|c3H5 NXfr[4VDOTBizszN MUjEUXNQ M3zGfmlEPTB:MUCg{txO MWSxPFA5QDB7Nx?=
HuH-7 NW\NTZhLS3m2b4TvfIlkKEG|c3H5 NVPQXpIzOTBizszN NHHqcXBFVVOR NXnZb2pmUUN3MEyxNEDPxE1? MkWzNVgxQDhyOUe=
OCI-Ly3 NIrKO3FHfW6ldHnvckBCe3OjeR?= M3zzZVExKM7:TdMg NIP4NIY1KGh? NUn4S|VrTE2VTx?= NEn6RZVKdmS3Y3XzJIh2dWGwIFnrZZBx[UKjbIDoZUB{fGGkaXzpfoF1cW:wIIfpeIghTUN3MDDv[kAyKM7:TR?= MUexPFAzPDFzMx?=
A2780 cDDP NX;tXXNCSXCxcITvd4l{KEG|c3H5 NWO3bGxjOjRiaB?= M{LSSWROW09? MVXJcoR2[2W|IHHwc5B1d3OrczDifUBqdmirYnn0bY5oKFCWRV6g[IVoemGmYYTpc44> MlTCNVc3QDRyMUi=
LPS-stimulated RAW264.7 cells NXrRSW9tTnWwY4Tpc44hSXO|YYm= NXnI[4hyTE2VTx?= NVvQUJZWUW6qaXLpeJMhVkZva3HwdIFDKESQQTDibY5lcW6p M4KxdlE4PDB5Mke3
PC12 MWjGeY5kfGmxbjDBd5NigQ>? NX;nTHc5OTByIN88UeKh NEHobmEzPCCq MlrvSG1UVw>? NHrhTmpKdmirYnn0d{A3NU:KRFGtJIFv\CCKMl:yMYlv\HWlZXSgZ5l1d3SxeHnjbZR6 MV:xO|E2QDR3NB?=
PC3 NWnWWVlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vxT|IxKM7:TR?= NGLGNos1QCCq MmP1SG1UVw>? MkjVTWM2OD1yLk[g{txO NFznc5cyPjZ6NkWzOy=>
LP-1 M3ntU2Fxd3C2b4Ppd{BCe3OjeR?= Mli4N|AxKG6P NYDuSnBrOjRiaB?= NW\zfW1STE2VTx?= NVPn[ppSUW6mdXPld{BieG:ydH;zbZMh[nliaX7jdoVie2mwZzDjcIVifmWmIGDBVnAhdGW4ZXygZY5lKHKnZIXjbY5oKE2lbD2xJJBzd3SnaX6gcIV3\Wx? NWXZW4h6OTV7NUi1PFk>
ES6 MlXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;pcphKSzVyPUCuNFE{ODZizszN MV7TRW5ITVJ?
A101D MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13kdWlEPTB;MD6wN|I4QSEQvF2= MXrTRW5ITVJ?
OCUB-M MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUiwXHg5UUN3ME2wMlA{PzN5IN88US=> M3TzUHNCVkeHUh?=
LB2518-MEL NITlRpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDuTWM2OD1yLkCzO|Yh|ryP NG\tbIpUSU6JRWK=
SH-4 M{Poe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1P2WGlEPTB;MD6wOFMyKM7:TR?= NHzzPJFUSU6JRWK=
KNS-42 Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrBV3A{UUN3ME2wMlA1PDRzIN88US=> MVLTRW5ITVJ?
DSH1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHKemlKSzVyPUCuNFUzQDlizszN NWf3VVZPW0GQR1XS
NTERA-S-cl-D1 M1\XNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWyVVgxUUN3ME2wMlA2Pzd{IN88US=> MkLhV2FPT0WU
D-542MG MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfCT3B6UUN3ME2wMlA2QTV5IN88US=> NIfaWpNUSU6JRWK=
KS-1 M4fPWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nLT2lEPTB;MD6wOlQ2QCEQvF2= NY\rPZliW0GQR1XS
BL-41 NWTxfZVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr4TWM2OD1yLkC2PVQ4KM7:TR?= NWHJWIpLW0GQR1XS
LXF-289 MmrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPoTWM2OD1yLkC3NFY3KM7:TR?= Mor1V2FPT0WU
D-247MG NYniUHNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDhTWM2OD1yLkC3NlA6KM7:TR?= M1fIZXNCVkeHUh?=
MMAC-SF NIPYeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfwVoZKSzVyPUCuNFczPjhizszN MXnTRW5ITVJ?
CP66-MEL MlmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{OzTWlEPTB;MD6wO|Uh|ryP NVnmW5JbW0GQR1XS
LB771-HNC M4f6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLqcHZuUUN3ME2wMlA5ODN4IN88US=> MX\TRW5ITVJ?
no-10 M3HD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;STWM2OD1yLkC4PVA6KM7:TR?= NVnPWIxjW0GQR1XS
A388 NYTQPW1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL2VYZKSzVyPUCuNFkxPjVizszN M3zjbHNCVkeHUh?=
OPM-2 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMUC0O|Qh|ryP NEPLXm1USU6JRWK=
OVCAR-4 NVLtdWR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMUC5N|gh|ryP NHT1dJRUSU6JRWK=
HOP-62 NGi2SVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljUTWM2OD1yLkGwPVQ6KM7:TR?= NUWwe5V7W0GQR1XS
ML-2 NVT6WYJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fiWmlEPTB;MD6xNVgxPiEQvF2= NHvPTZRUSU6JRWK=
UACC-257 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDXZ2tKSzVyPUCuNVE6OjdizszN NHHteWtUSU6JRWK=
NEC8 MmfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn6wTWM2OD1yLkGxPVk2KM7:TR?= M3\COXNCVkeHUh?=
ONS-76 M1y1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXYZYxKSzVyPUCuNVI6OzVizszN Mo[yV2FPT0WU
KE-37 MkO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMUOyO|gh|ryP MX3TRW5ITVJ?
HT-144 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMUO4PVUh|ryP NV[wUZFkW0GQR1XS
LB2241-RCC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[4WWJFUUN3ME2wMlE1OjR5IN88US=> MnPTV2FPT0WU
TE-5 NYTIcXdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i0Z2lEPTB;MD6xOFI4QCEQvF2= MmnwV2FPT0WU
KINGS-1 NUnUVXRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmS1TWM2OD1yLkG0O|kh|ryP M2PsV3NCVkeHUh?=
NCI-H69 M{XpVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHKTWM2OD1yLkG1NVQyKM7:TR?= NH35ZmJUSU6JRWK=
CAS-1 MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf3SZgxUUN3ME2wMlE2PDh{IN88US=> M2TCXXNCVkeHUh?=
D-263MG NV;LRYhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nsNmlEPTB;MD6xOlAxPiEQvF2= M4nGZnNCVkeHUh?=
A253 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rkXGlEPTB;MD6xOlEzQCEQvF2= MVzTRW5ITVJ?
PF-382 M4j6fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTSTWM2OD1yLkG2O|A3KM7:TR?= NHnTWI5USU6JRWK=
CESS NVS0XJhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HXXGlEPTB;MD6xO|A3KM7:TR?= NYjreo9jW0GQR1XS
MZ2-MEL NI\vWWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rqZWlEPTB;MD6xO|U2QSEQvF2= MnHTV2FPT0WU
HEL M2P4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMUi1NVch|ryP M3\DPHNCVkeHUh?=
D-392MG NHywRpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTMb4xKSzVyPUCuNVkyOTVizszN MYXTRW5ITVJ?
SK-LMS-1 M1HB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMUmzNFMh|ryP MnHiV2FPT0WU
GI-ME-N M1n3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf2TWM2OD1yLkG5N|A3KM7:TR?= M{\LPHNCVkeHUh?=
LB831-BLC Mo\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTacVI{UUN3ME2wMlE6OzRizszN NF;ad|RUSU6JRWK=
DU-4475 NF3FSIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;OS2lEPTB;MD6xPVY2QCEQvF2= MlfPV2FPT0WU
IST-SL1 M{jxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2X2T2lEPTB;MD6yNFA6PCEQvF2= MlTPV2FPT0WU
GAK NWXwNZdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T2T2lEPTB;MD6yNFU{PCEQvF2= NYnvNoRUW0GQR1XS
EW-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq1OFFKSzVyPUCuNlExPDdizszN M1;6N3NCVkeHUh?=
LAMA-84 NFjMeJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITBTnRKSzVyPUCuNlE5PTFizszN NGmwSZVUSU6JRWK=
SK-UT-1 MnHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHxeZJ3UUN3ME2wMlIzODR7IN88US=> MXrTRW5ITVJ?
VA-ES-BJ MoX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXQRYVKSzVyPUCuNlIzPTdizszN NYTINnB6W0GQR1XS
ACN NXrITJEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zG[mlEPTB;MD6yNlY{QCEQvF2= NWX0NI55W0GQR1XS
SK-PN-DW M3XZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfZbFdjUUN3ME2wMlI{OTlizszN M1vIVXNCVkeHUh?=
HD-MY-Z MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\JN2lEPTB;MD6yN|MxOyEQvF2= NFy0W3NUSU6JRWK=
LB373-MEL-D MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\EPG43UUN3ME2wMlI1OTl6IN88US=> NXz2V5oxW0GQR1XS
COLO-829 NYXufld6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HwfWlEPTB;MD6yOFI2PyEQvF2= NXPLRWZnW0GQR1XS
ES8 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPye5FKSzVyPUCuNlQ4PjNizszN NGLPS3VUSU6JRWK=
RXF393 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3roUWlEPTB;MD6yOVAyPSEQvF2= NUXXdWI1W0GQR1XS
TK10 M2\oNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDrUXlKSzVyPUCuNlU1OzVizszN NWK4[mJEW0GQR1XS
LOUCY NH3IdHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K0W2lEPTB;MD6yOVQ2PiEQvF2= Mof2V2FPT0WU
MZ7-mel NGHCeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXnUWZkUUN3ME2wMlI3Ozd2IN88US=> NF;VZoxUSU6JRWK=
CP67-MEL MkK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMk[3N{DPxE1? NEW4T5ZUSU6JRWK=
C2BBe1 NGPFfohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMke5NFch|ryP NHWxS4dUSU6JRWK=
K052 NXnX[|FCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnQTWM2OD1yLkK4PVkh|ryP Mk\yV2FPT0WU
MOLT-16 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFz2Z5lKSzVyPUCuNlk2OjRizszN M2DLTXNCVkeHUh?=
KNS-81-FD MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDM[25pUUN3ME2wMlMxOzJ|IN88US=> NHPjfIFUSU6JRWK=
CMK MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfNOnVKSzVyPUCuN|EyOiEQvF2= M2Drc3NCVkeHUh?=
LAN-6 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XJ[2lEPTB;MD6zNVMh|ryP MnfXV2FPT0WU
KLE MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7hTWM2OD1yLkOxN|A3KM7:TR?= M37ZVXNCVkeHUh?=
NCCIT NV;XboZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYS5VlY5UUN3ME2wMlMyPzh|IN88US=> MnizV2FPT0WU
HH M4W3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVS0VHRrUUN3ME2wMlMzQDl5IN88US=> NGDWXmxUSU6JRWK=
TE-8 NX3xVFZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LiTGlEPTB;MD6zOFI4QSEQvF2= NYryXVBLW0GQR1XS
GDM-1 NVnqNYxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XKcmlEPTB;MD6zOVExPCEQvF2= NX\tcVZNW0GQR1XS
NCI-H747 MnnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jOXGlEPTB;MD6zO|ExOyEQvF2= MlLPV2FPT0WU
NCI-H1092 M13uS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPiem5KSzVyPUCuN|g5PDRizszN MVzTRW5ITVJ?
8-MG-BA NV\0OXlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonKTWM2OD1yLkO5PFM4KM7:TR?= NILS[FlUSU6JRWK=
NB17 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwNEK5O{DPxE1? NF7LUm1USU6JRWK=
LC4-1 M4DVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPEXmZPUUN3ME2wMlQ{PjB5IN88US=> NHq5bJhUSU6JRWK=
TE-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLsOJJKSzVyPUCuOFUyOTlizszN MWPTRW5ITVJ?
KALS-1 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\mW2gzUUN3ME2wMlQ3PTh2IN88US=> NYHWPHRqW0GQR1XS
CCRF-CEM MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPRcoNPUUN3ME2wMlQ4Pjd2IN88US=> M4TFW3NCVkeHUh?=
OS-RC-2 NF;tVIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vodGlEPTB;MD60O|k4OiEQvF2= MoPkV2FPT0WU
A704 NYnTWnpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;xUXFKSzVyPUCuOFg3QTJizszN NV;tU4pnW0GQR1XS
BB49-HNC NFK5N|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\tOWlEPTB;MD60PVA6PiEQvF2= MnzUV2FPT0WU
EVSA-T NXPqXpMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwNEm5NVEh|ryP NWrJcFZMW0GQR1XS
Mo-T MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nYfmlEPTB;MD61NVc3OiEQvF2= NHzUdGpUSU6JRWK=
MONO-MAC-6 M2HqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwNUO2NVEh|ryP NHXRc41USU6JRWK=
BB65-RCC M{HUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv6WI5LUUN3ME2wMlU3QDFzIN88US=> NYPOcYJFW0GQR1XS
NCI-H1882 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\JbFdrUUN3ME2wMlU6ODN4IN88US=> M175SXNCVkeHUh?=
TE-9 MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq5[GtHUUN3ME2wMlYyODN|IN88US=> NWm3OnlpW0GQR1XS
NCI-H2126 NEHobI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwNkK2Olkh|ryP Mor1V2FPT0WU
SF268 NXK5bJRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPFWXFKSzVyPUCuOlU3PDFizszN NH3ifFVUSU6JRWK=
SW872 M{fMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwNkW3Nlkh|ryP NFzDelFUSU6JRWK=
LS-513 MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDoS|U5UUN3ME2wMlY3PzVzIN88US=> MoD3V2FPT0WU
NCI-H1355 MmS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwNki2NVkh|ryP MWLTRW5ITVJ?
BL-70 M3npdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\OVZZYUUN3ME2wMlY6Ozh6IN88US=> MnzMV2FPT0WU
NCI-SNU-5 NHvmXVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;XTWM2OD1yLk[5OVQ2KM7:TR?= NHf1TIxUSU6JRWK=
SNU-C2B M1rYUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXheo9KSzVyPUCuO|A4OzlizszN MnTDV2FPT0WU
GB-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vUNWlEPTB;MD63NlEzPCEQvF2= MXLTRW5ITVJ?
CTB-1 MnLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwN{e5OVUh|ryP MlLCV2FPT0WU
Becker MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDCZm5KSzVyPUCuO|k3OjFizszN NF\TU5dUSU6JRWK=
KM12 MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwOEW0OlYh|ryP NXLCOHY{W0GQR1XS
ES7 NUDRV2hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwOEm2OUDPxE1? MUXTRW5ITVJ?
COLO-684 NXPDRmJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwOUC2OVgh|ryP NG[weGFUSU6JRWK=
HCC2998 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTDfY1KSzVyPUCuPVM5PTRizszN NGjDU3BUSU6JRWK=
TE-10 NXLtZWkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwOU[0N{DPxE1? M{X5SnNCVkeHUh?=
SF126 NETyPGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;qZoRKSzVyPUCuPVg6PzFizszN NGr3TYVUSU6JRWK=
EKVX MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnG0TWM2OD1zLkCzOFQzKM7:TR?= MXnTRW5ITVJ?
KARPAS-45 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rrcGlEPTB;MT6wOFAyPiEQvF2= M{\r[HNCVkeHUh?=
KGN NUS3c|lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGzZVhXUUN3ME2xMlA2ODR3IN88US=> NF65[GNUSU6JRWK=
ES1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPVdWRkUUN3ME2xMlA4QTJzIN88US=> MoTsV2FPT0WU
L-540 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHo[lc3UUN3ME2xMlEyQDN7IN88US=> M4LsXnNCVkeHUh?=
KURAMOCHI MnntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTFwMUKzO|Qh|ryP MmDVV2FPT0WU
LU-65 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37xOGlEPTB;MT6xNlc2OyEQvF2= MofiV2FPT0WU
MFH-ino MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[5bIpKSzVyPUGuNVc2ODFizszN NHPzcIlUSU6JRWK=
NCI-H23 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC4RW9KSzVyPUGuNlA1OSEQvF2= NVjHeoNqW0GQR1XS
IA-LM MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi1ZpNKSzVyPUGuNlQyOTZizszN NFjxXHBUSU6JRWK=
PSN1 M2PLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfXeWg2UUN3ME2xMlI4ODF4IN88US=> NXHTWlZuW0GQR1XS
NCI-H719 MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTFwMke0NVEh|ryP MkDyV2FPT0WU
SW684 NEfTbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFwMki2OVkh|ryP NUnC[JhbW0GQR1XS
HCE-4 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqyTWM2OD1zLkOwNlIyKM7:TR?= MUTTRW5ITVJ?
EW-16 M{fIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz3W21qUUN3ME2xMlMyOzR5IN88US=> MXnTRW5ITVJ?
NCI-H128 NVrpOm9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTiNGFKSzVyPUGuN|U5OTRizszN M1jaeXNCVkeHUh?=
HC-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFwM{ixO{DPxE1? NIDJemNUSU6JRWK=
IST-MES1 MojCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fnZ2lEPTB;MT60NFIxQCEQvF2= NVP6fW17W0GQR1XS
Raji M3LtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XQe2lEPTB;MT60NVg2KM7:TR?= NYCyRXpPW0GQR1XS
DMS-114 M37FSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrEPId6UUN3ME2xMlQ1PTN7IN88US=> MnfXV2FPT0WU
GI-1 M4nPVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvNfVJkUUN3ME2xMlQ4OTNzIN88US=> M3XJOHNCVkeHUh?=
NCI-H2081 NWXBbIxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDNUllKSzVyPUGuOVUyQTZizszN Mo\BV2FPT0WU
LC-1F NIPQVW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfIVGZKSzVyPUGuOVUyQThizszN MUPTRW5ITVJ?
NCI-H2227 M4LqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjHZ3p6UUN3ME2xMlYyPTZzIN88US=> MnroV2FPT0WU
D-502MG NEnUbHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXQTWM2OD1zLk[3NlEyKM7:TR?= NHHuPZpUSU6JRWK=
NCI-H2141 NGTJXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn2WGpKSzVyPUGuOlc{OTdizszN NYjNcplrW0GQR1XS
LS-411N M3Pzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu0S4NFUUN3ME2xMlY6QDB5IN88US=> MmD6V2FPT0WU
SU-DHL-1 NWn4cmZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofLTWM2OD1zLkexNlgyKM7:TR?= MlTKV2FPT0WU
BB30-HNC NHS3WGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGCyTXNKSzVyPUGuO|I3QDVizszN M3jDd3NCVkeHUh?=
TE-15 M{PXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwOUKzO|Mh|ryP M3m4[3NCVkeHUh?=
JVM-3 NF\Jb2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFwOUO5NFQh|ryP M{XHdHNCVkeHUh?=
IST-SL2 M13Le2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;nTmlEPTB;Mj6wNVI2OiEQvF2= NGnP[GFUSU6JRWK=
EW-18 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJwMEKzN|ch|ryP NUnzOZEyW0GQR1XS
DJM-1 NHTSTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWG5UJpxUUN3ME2yMlAzPTV{IN88US=> M1PEXXNCVkeHUh?=
no-11 M1r1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJwMEOxNFQh|ryP MnTIV2FPT0WU
QIMR-WIL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJwMU[3OlIh|ryP Mkj6V2FPT0WU
MC-CAR Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJwMkK5OUDPxE1? MULTRW5ITVJ?
KM-H2 M{fKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjsTWM2OD1{LkK5NFQ{KM7:TR?= NGrZO4RUSU6JRWK=
ECC12 M2raTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3oR3pIUUN3ME2yMlM4QTRizszN MWDTRW5ITVJ?
HCE-T MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXzVIxKSzVyPUKuOFQ5QDNizszN MV7TRW5ITVJ?
MFM-223 MkTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljqTWM2OD1{LkWwPFcyKM7:TR?= NFftZ3FUSU6JRWK=
SW982 NX\qc|VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJwNUG0PEDPxE1? Mlu4V2FPT0WU
KG-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwOEi3PVEh|ryP M3rVSXNCVkeHUh?=
ES4 NEfoWZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlqxTWM2OD1|LkC2NVEyKM7:TR?= NEnvcJVUSU6JRWK=
SCC-3 MmHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLE[o9rUUN3ME2zMlExQDR6IN88US=> Mo\CV2FPT0WU
RH-1 NYrIZm9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\5OYl7UUN3ME2zMlM5PzR6IN88US=> NVLLOXM6W0GQR1XS
NCI-H748 MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rz[WlEPTB;Mz60OFI3PiEQvF2= NF\KPYxUSU6JRWK=
HCC2218 NV3qcW1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTNwNE[5N|ch|ryP NWXXeJZrW0GQR1XS
MEG-01 NFnzS3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTNwNUm2PEDPxE1? NEm4c2tUSU6JRWK=
NB12 NHzucW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTNwNUm4PFgh|ryP M1HYenNCVkeHUh?=
SNB75 NEjNWItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTNwNkCxNFMh|ryP M37GTXNCVkeHUh?=
KMS-12-PE MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\EXZJKSzVyPUOuOlc4OjNizszN NGDHPWlUSU6JRWK=
SKM-1 M2fERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTNwN{GzO|Yh|ryP M1fpPHNCVkeHUh?=
COLO-320-HSR MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn31TWM2OD1|Lke1OlM1KM7:TR?= M1TuZ3NCVkeHUh?=
NKM-1 NVL5cZhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\hNYxvUUN3ME2zMlc4Ozd6IN88US=> NGjhbG5USU6JRWK=
TE-6 MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[2W|BbUUN3ME2zMlk1PTZzIN88US=> MUTTRW5ITVJ?
D-336MG NED6TIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHrPWRNUUN3ME20MlAyOTZ4IN88US=> Ml7lV2FPT0WU
NCI-H1650 NUH3c4NGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRwMUW3PVch|ryP MXXTRW5ITVJ?
ES3 NGL3PHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfVW|hoUUN3ME20MlMzQDJ2IN88US=> NXHUUGhrW0GQR1XS
YT NHWzU5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7tTWM2OD12LkO1OFI1KM7:TR?= M1Hy[nNCVkeHUh?=
ES5 M3zqWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7mTWM2OD12LkSwNlU2KM7:TR?= MYDTRW5ITVJ?
LB647-SCLC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmftTWM2OD12LkW2N|A5KM7:TR?= MU\TRW5ITVJ?
HAL-01 M{XHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTRwNUewN|Qh|ryP MWDTRW5ITVJ?
LP-1 M2X4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTRwN{KzO|Eh|ryP NVHXbpdJW0GQR1XS
BC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHHfWZKSzVyPUWuNFA1PDdizszN NY\UdFQ{W0GQR1XS
EB-3 NIHxbJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDZ[XRKSzVyPUWuNFMxPDFizszN NIPUVm9USU6JRWK=
GT3TKB NFrD[2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:5OoZ5UUN3ME21MlE4PjZ{IN88US=> MXzTRW5ITVJ?
NCI-H209 NHXWd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTVwMUmzOVIh|ryP MlrOV2FPT0WU
BT-474 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkK3TWM2OD13LkKzNVAzKM7:TR?= MX\TRW5ITVJ?
RKO M3jXZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTVwMkO0NlIh|ryP M3PSb3NCVkeHUh?=
SIMA MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDETWM2OD13LkOwO|Y2KM7:TR?= M{DRbnNCVkeHUh?=
RL MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qwWGlEPTB;NT6zO|U1OSEQvF2= MWLTRW5ITVJ?
GCIY MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTVwNEeyN|Yh|ryP NUjCUGdiW0GQR1XS
Calu-6 M2nMWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTVwNkKyJO69VQ>? NHfk[JFUSU6JRWK=
ALL-PO Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NViyTVJkUUN3ME21MlY{Pzl3IN88US=> NGHZVm9USU6JRWK=
ARH-77 NYfNTodKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTVwNkewPFch|ryP NGDBNVZUSU6JRWK=
A4-Fuk M1vTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTZwMEixNVgh|ryP MmXtV2FPT0WU
NCI-H1581 Mon3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e3VGlEPTB;Nj6yN|g1QSEQvF2= MXjTRW5ITVJ?
HUTU-80 NW\3NlNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTZwM{[4PVch|ryP MmLhV2FPT0WU
TGW NIK0TmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnFUGlpUUN3ME22MlQ2PTl|IN88US=> MlrmV2FPT0WU
SK-N-FI NXLRNZFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLCTWM2OD14LkS1PFU1KM7:TR?= M4r1dHNCVkeHUh?=
U-266 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;l[lRWUUN3ME22MlUyQTJ4IN88US=> NXPQT4NIW0GQR1XS
EM-2 M3ThcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTZwNkewPVkh|ryP NULvPXoyW0GQR1XS
NMC-G1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDDTWM2OD14LkexPFk2KM7:TR?= MnrtV2FPT0WU
KASUMI-1 NIDCc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi2NIpHUUN3ME22Mlg1Pzh5IN88US=> NITrWJNUSU6JRWK=
NALM-6 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\Le5lKSzVyPU[uPFY4PTRizszN NEnSPZhUSU6JRWK=
OCI-AML2 M4nHPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4mzSGlEPTB;Nz6wNFMzPiEQvF2= M3i4dHNCVkeHUh?=
SHP-77 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3ETWM2OD15LkKyOFMh|ryP NUDKdYJnW0GQR1XS
NOMO-1 MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HH[2lEPTB;Nz6yOFI2PCEQvF2= NUL2PVdDW0GQR1XS
SK-N-DZ NV7ISHE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTdwN{GwPFkh|ryP Ml;pV2FPT0WU
LB1047-RCC M3jIZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7HSoNKSzVyPUeuO|IzOzFizszN NF\hPYJUSU6JRWK=
MZ1-PC MkH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTdwOE[1OVgh|ryP MXzTRW5ITVJ?
NB10 MoXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m1OmlEPTB;Nz65PVU2PiEQvF2= NEHFeppUSU6JRWK=
RL95-2 M4jBbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LpbGlEPTB;OD6xNFg1OiEQvF2= NGqzZZRUSU6JRWK=
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SCLC-21H NF7wdGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTFyLk[1PVYh|ryP NV\QdJRFW0GQR1XS
EC-GI-10 NV24PI8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PJdGlEPTB;MUCuO|A{OSEQvF2= MYDTRW5ITVJ?
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NCI-H1648 NH65O4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTFzLkC5OlUh|ryP NYjP[pNOW0GQR1XS
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MHH-NB-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XieGlEPTB;MUOuNlkxOiEQvF2= MnrhV2FPT0WU
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NCI-N87 NXfIT2xwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTF|LkezOkDPxE1? NUn5NnJoW0GQR1XS
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MSTO-211H NFvxRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXkenVoUUN3ME2xOE44PDR6IN88US=> NXvGSW9SW0GQR1XS
JVM-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjMWlJYUUN3ME2xOE44PzN3IN88US=> NHTwfYNUSU6JRWK=
COLO-824 NX\SRWNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nzZ2lEPTB;MUSuO|k6PCEQvF2= Ml;vV2FPT0WU
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GOTO NGnCbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInXWnpKSzVyPUG2Mlk3OTdizszN NYrQbYNuW0GQR1XS
HCC2157 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPDTZRTUUN3ME2xO{41PzV3IN88US=> M{XTR3NCVkeHUh?=
LS-1034 NIXIUlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\2SmlEPTB;MUeuOlgyQCEQvF2= NELzWnFUSU6JRWK=
CAL-148 M{HyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTF5Lkm3PVYh|ryP M{noeHNCVkeHUh?=
MOLT-4 MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTF6LkiyNFgh|ryP Mk\2V2FPT0WU
Daudi Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDCNoRKSzVyPUG4MlkzOzFizszN NYPpcW1[W0GQR1XS
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KMOE-2 MnLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jCbGlEPTB;MUmuOlQ5OiEQvF2= MVvTRW5ITVJ?
HL-60 NHf3Z5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJyLkG5OlUh|ryP MlLXV2FPT0WU
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IM-9 Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrOXVhKSzVyPUKwMlYzOjRizszN NIryfm5USU6JRWK=
HDLM-2 MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT6TWM2OD1{MD64PFIyKM7:TR?= MX;TRW5ITVJ?
NCI-H1304 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;OfWlLUUN3ME2yNU4xOzFzIN88US=> NI\hcWFUSU6JRWK=
NCI-H345 MmPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{mxc2lEPTB;MkGuNFY1OyEQvF2= MUHTRW5ITVJ?
RPMI-6666 M3XNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4KxbWlEPTB;MkGuN|YxOiEQvF2= MX\TRW5ITVJ?
GR-ST NFfZdZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJzLkSxO{DPxE1? M1fLTnNCVkeHUh?=
CHP-126 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJzLk[xPFEh|ryP MoTPV2FPT0WU
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CPC-N MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH4TWM2OD1{ND6wNlAyKM7:TR?= MlniV2FPT0WU
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LS-123 M4S4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DMRmlEPTB;MkSuPVAyOiEQvF2= M1fEO3NCVkeHUh?=
ST486 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7LTWM2OD1{NT6xNVE{KM7:TR?= MorIV2FPT0WU
NCI-H1963 NWHaRY9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJ4LkC2NlMh|ryP MnW2V2FPT0WU
U-87-MG Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjPN2I4UUN3ME2yOk44PjR2IN88US=> MkLCV2FPT0WU
COR-L279 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH5bm5KSzVyPUK2Mlc6OjJizszN MWDTRW5ITVJ?
LU-165 NGKx[XVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJ6LkC4OlEh|ryP M2W1NnNCVkeHUh?=
COLO-800 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfGTWM2OD1{OD6yPVU3KM7:TR?= NVXFeXlTW0GQR1XS
ETK-1 NX;mbVJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnjZoVKSzVyPUK4MlM1PDZizszN MnPEV2FPT0WU
LNCaP-Clone-FGC NViyZXc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjTTWM2OD1{OT65NlgyKM7:TR?= NXriZlE4W0GQR1XS
SIG-M5 Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n3UWlEPTB;M{CuO|k2OiEQvF2= Mn\nV2FPT0WU
NB6 NYT1Zm85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rzZ2lEPTB;M{CuPVUxOyEQvF2= MoruV2FPT0WU
NCI-H2107 NFLBOJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLGNIR{UUN3ME2zNU4zOzN6IN88US=> NH\2c3RUSU6JRWK=
SNU-C1 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUWzSo1jUUN3ME2zNU4{OTJ4IN88US=> NGnaUm5USU6JRWK=
JAR NE[2OphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTNzLkO3PVkh|ryP MnW0V2FPT0WU
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NB69 M37lT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfIZWdRUUN3ME2zN{43PDV2IN88US=> NIO4[HNUSU6JRWK=
EW-13 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnMTWM2OD1|Mz64PVY6KM7:TR?= M17BOnNCVkeHUh?=
Ramos-2G6-4C10 NH3Zd3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnOVmtYUUN3ME2zOE4zQTl|IN88US=> NIG2cWlUSU6JRWK=
TE-11 MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrNTYJTUUN3ME2zOE41QDJ{IN88US=> MlnOV2FPT0WU
L-428 M4iyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW0fVV5UUN3ME2zOE44PTN4IN88US=> NVvuOmk1W0GQR1XS
KP-N-YN MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LtNWlEPTB;M{SuPVA2PyEQvF2= NXvaPWpSW0GQR1XS
CGTH-W-1 M3rLNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELYVmtKSzVyPUO2MlkxPDhizszN NXfGPFNrW0GQR1XS
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NCI-H1299 M33YWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37Od2lEPTB;M{iuNVYxOyEQvF2= MnO3V2FPT0WU
RCC10RGB M4D2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTN6LkKwPFMh|ryP MYjTRW5ITVJ?
NCI-SNU-16 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fROWlEPTB;M{iuOVY2OyEQvF2= NH7GTG5USU6JRWK=
LC-2-ad MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTN7LkSzN|ch|ryP MUfTRW5ITVJ?
MHH-PREB-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj4TWM2OD1|OT63N|g5KM7:TR?= MUPTRW5ITVJ?
NCI-H64 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nqWGlEPTB;NECuNFk1QCEQvF2= MYLTRW5ITVJ?
LB996-RCC NGG5WIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDsUFJmUUN3ME20NE45PzF4IN88US=> MWDTRW5ITVJ?
DEL NI\vXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTRzLkS0NFUh|ryP NFGwfI9USU6JRWK=
MLMA NHq1[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL1ZYRKSzVyPUSxMlc2QTVizszN M3HacHNCVkeHUh?=
SBC-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LFe2lEPTB;NEKuNVgxPiEQvF2= NISwWVZUSU6JRWK=
MPP-89 NUD0OIJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofoTWM2OD12Mj61PFc2KM7:TR?= NISxb4lUSU6JRWK=
MV-4-11 NUfE[4FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXO4dWtnUUN3ME20Nk46ODZ5IN88US=> MY\TRW5ITVJ?
EoL-1- MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHFbJJKSzVyPUS0MlE2PjhizszN MlnHV2FPT0WU
CW-2 M2rnTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Dn[mlEPTB;NESuPFM1OiEQvF2= NVjvcphMW0GQR1XS
HT NY[1XVh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLUZVBKSzVyPUS1MlcxODdizszN M{[2enNCVkeHUh?=
SW954 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ixTmlEPTB;NEeuOFEzQCEQvF2= MVXTRW5ITVJ?
A3-KAW MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTR7LkiwOlEh|ryP M3TTc3NCVkeHUh?=
TC-YIK MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\XTZVKSzVyPUWwMlA{PjNizszN M3vXU3NCVkeHUh?=
SW962 Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;J[GlEPTB;NUSuPFM2PyEQvF2= NYOxcZJsW0GQR1XS
KP-N-RT-BM-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTV4Lk[2N|gh|ryP Ml;yV2FPT0WU
NCI-H1395 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPSdm5KSzVyPUW4MlgyPzJizszN NGHzZ5JUSU6JRWK=
RPMI-8402 M1rrUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPSPYNKSzVyPUW4Mlk2OjZizszN NFfi[lhUSU6JRWK=
SCH MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvObWFoUUN3ME22NE46PjN6IN88US=> MWnTRW5ITVJ?
NCI-H2196 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTa[llKSzVyPU[xMlI{OSEQvF2= M2jJSHNCVkeHUh?=
LOXIMVI MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoGzTWM2OD14MT64NlY3KM7:TR?= MWnTRW5ITVJ?
TGBC24TKB NGPQUINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHRZVRKSzVyPU[yMlE1QTFizszN MoXjV2FPT0WU
SK-MEL-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjDSo0yUUN3ME22N{46QDl{IN88US=> MXPTRW5ITVJ?
U-698-M MoDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHQUWxKSzVyPU[4MlU3QDdizszN Mlu2V2FPT0WU
NCI-H1522 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nXcmlEPTB;NkmuNFA1PyEQvF2= MYjTRW5ITVJ?
UACC-812 M1rLUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jod2lEPTB;NkmuOVIxQSEQvF2= MlLCV2FPT0WU
MHH-CALL-2 MknMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT3T5JWUUN3ME23NE4xPiEQvF2= MU\TRW5ITVJ?
NB5 NWX4dohrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTdyLkO0Olgh|ryP NIn5SpdUSU6JRWK=
KARPAS-299 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq2botKSzVyPUewMlQ1PDdizszN M2TKRnNCVkeHUh?=
NCI-H1694 NHrSVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq4TWM2OD15MT6wN|Ih|ryP MV\TRW5ITVJ?
NCI-H82 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\4ZW5KSzVyPUexMlk2ODdizszN MWLTRW5ITVJ?
SCC-15 M1Xh[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnDTWM2OD15Mj6zOEDPxE1? Ml;LV2FPT0WU
NCI-H1436 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P4W2lEPTB;N{KuO|Q2PiEQvF2= NUCyUYxTW0GQR1XS
ATN-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTd2LkWwOUDPxE1? M3LGVHNCVkeHUh?=
RPMI-8866 NU\yNVVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XjXWlEPTB;N{SuO|UxQSEQvF2= M1rBe3NCVkeHUh?=
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... Click to View More Cell Line Experimental Data

In vivo試験 Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Measurement of inhibitory activities of MG-132 against 20S proteasome The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.

細胞アッセイ:

[3]

細胞株 KIM-2, HC11, and ES
濃度 Dissolved in DMSO, final concentrations ~25 μM
反応時間 24, and 48 hours
実験の流れ

Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.

動物実験:

[7]

動物モデル Male mdx (C57BL/10ScSn DMD mdx) mice
製剤 Dissolved in DMSO, and diluted in PBS
投薬量 ~10 μg/kg/day
投与方法 Injection

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MG-132 SDF
分子量 475.62
化学式

C26H41N3O5

CAS No. 133407-82-6
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 95 mg/mL (199.73 mM)
Ethanol 95 mg/mL (199.73 mM)
Water <1 mg/mL
In vivo 4% DMSO+30% PEG 300+20% propylene glycol+ddH2O 2mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate

文献中の引用 (46)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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