MG-132 化学構造
分子量: 475.62

高品質保証

文献中の引用(46)

カスタマーフィードバック(9)

Quality Control & MSDS

製品説明

  • Compare Proteasome Inhibitors
    Proteasome製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MG-132は、100nMのIC50によるプロテアソームの強力な阻害剤です。
ターゲット

Proteasome

IC50

100 nM [1]

In vitro試験 MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
LPS-stimulated RAW264.7 cells Mn;RSpVv[3Srb36gRZN{[Xl? Mon5NlUh|ryP NYDkPJU4TE2VTx?= MXTJcohq[mm2czDubZRzcWNib4jp[IUheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE4yKM7:TR?= NXjXNGl5OjR4OUe0PVY>
HL-60 MYnDfZRwfG:6aXOgRZN{[Xl? M3zFelQxKM7:TR?= NXLsfGVnPDhiaB?= MljVSG1UVw>? MUTJR|UxRDFyIN88US=> MX6yOFY6PzR7Nh?=
SMMC-7721 MUHDfZRwfG:6aXOgRZN{[Xl? MkjiOFAh|ryP Mof0OFghcA>? NV;yS5JHTE2VTx?= NVuyTXRtUUN3ME23MlEh|ryP MUKyOFY6PzR7Nh?=
A-549 M33KcWN6fG:2b4jpZ{BCe3OjeR?= MX[0NEDPxE1? MYm0PEBp NXnDTW1OTE2VTx?= Mo\JTWM2ODxzMDFOwG0> NEWw[3UzPDZ7N{S5Oi=>
MCF-7 M{PiS2N6fG:2b4jpZ{BCe3OjeR?= MnHrOFAh|ryP NXrKfIk5PDhiaB?= NX25cocyTE2VTx?= Ml25TWM2OD15LkOg{txO NY\TbZJZOjR4OUe0PVY>
SW-480 NV3G[m1[S3m2b4TvfIlkKEG|c3H5 MWq0NEDPxE1? MYO0PEBp M1rNcmROW09? NHLYTXlKSzVyPUSg{txO MmLmNlQ3QTd2OU[=
NCI-H929 NWrl[JBTS3m2b4TvfIlkKEG|c3H5 M1e5PFEh|ryP MonFO|IhcA>? NUWwOGpVTE2VTx?= Mo\rTWM2OD1yLkG3JO69VQ>? Mk\SNlQ3OjVyOEi=
293T NIPJNHlEgXSxdH;4bYMhSXO|YYm= Mn3ENVAh|ryP NXLTNI1JPzJiaB?= MorCSG1UVw>? MmD5TWM2ODx{IN88US=> NWDHbHQ1OjR4MkWwPFg>
293T MVjGeY5kfGmxbjDBd5NigQ>? Mn7VNVAh|ryP M17zZlI1KGh? M4jpS2ROW09? NVmzVnRqVW:mZYLheIVtgSCrbnT1Z4V{KGinYYStd4hw[2tiIB?= MX2yOFYzPTB6OB?=
HeLa NUe3UpZ2U2mwYYPlJGF{e2G7 NGXVSYgyOCEQvF2= NXnwPFMyOSCq M4L1SGROW09? NHvnZmlKdmS3Y3XzJHBCWlBiY3zlZZZi\2ViYomgbY5pcWKrdHnu[{Bxem:|ZXHzc41mKGGldHn2bZR6 M2TU[FI1OzJzOEOz
MDA-MB-231 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq2NUDPxE1? Ml7DO|IhcA>? MV;EUXNQ Mk[5TWM2OD1yLkG4JO69VQ>? M1fPW|I1OTV|MkC2
MCF-7 NGjRNGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXmxJO69VQ>? NEGxelU4OiCq NYCwNnA{TE2VTx?= NHz0VGFKSzVyPUCuNVMh|ryP MVKyOFE2OzJyNh?=
MCF10A NHjPN2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[zWWV1OSEQvF2= MWW3NkBp NVX1VI1STE2VTx?= NYnYTo1TUUN3ME2wMlI6KM7:TR?= MV2yOFE2OzJyNh?=
HEK-293 MVLLbY5ie2ViQYPzZZk> MVeyJIFv\CB{MDFOwG0> MWCyJIg> MWTEUXNQ NFzyNWxKdmirYnn0d{BEcFRvTDDhZ5Rqfmm2eTD3bZRpKEmFNUCgc4YhQSCwTTC= M{WwR|I{PTRyN{mw
Calu6 NEHJRnZHfW6ldHnvckBCe3OjeR?= MlvYNVAh|ryP MV6xPEBp MUnEUXNQ M1H6OnNq\26rZnnjZY51dHliYXPjeY12dGG2ZYOg[pJifGG6aX6gdJJm[3W{c3;y MYiyN|UxPjR6Nh?=
IFN-gamma-induced RAW264.7 NXHXR5hlTnWwY4Tpc44hSXO|YYm= NXHtOXRsTE2VTx?= M3nGZ2lvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjB5NzFOwG0> MVKyNlI4PzJ5Nx?=
IPC227F NVXENYZoS3m2b4TvfIlkKEG|c3H5 NXTk[o5ZOSEQvF2= MnXqOFghcA>? MUPEUXNQ NIXiN4JKSzVyPUCuNFc4KM7:TR?= NWX2c4pFOjF7MkS1Nlg>
Hepa-1c1c7 MYDGeY5kfGmxbjDBd5NigQ>? NEnxdGYzPSEQvF2= NVzqNIRzPiCq M1TQWmROW09? NVzhbZV2UW6lcnXhd4V{KE6{ZkKgdJJwfGWrbjDs[ZZmdA>? NUDSbm9COjB|OUK1OFQ>
COS-7 M3yxUmN6fG:2b4jpZ{BCe3OjeR?= M1yzclExKM7:TR?= MkTLSG1UVw>? MV3JR|UxRDFyIN88US=> NYnJdW9UOThyOEiwPVc>
HuH-7 Mn[1R5l1d3SxeHnjJGF{e2G7 M{jI[|ExKM7:TR?= NGTxTJlFVVOR MX7JR|UxRDFyIN88US=> NWrmUG9QOThyOEiwPVc>
OCI-Ly3 NHyzcG5HfW6ldHnvckBCe3OjeR?= NUm5bWxEOTBizszNxsA> M2LKOlQhcA>? MVnEUXNQ M2K4Vmlv\HWlZYOgbJVu[W5iSXvhdJBiSmGucHjhJJN1[WKrbHn6ZZRqd25id3n0bEBGSzVyIH;mJFEh|ryP NYra[m57OThyMkSxNVM>
A2780 cDDP NXn1dYZHSXCxcITvd4l{KEG|c3H5 MV[yOEBp NETKPZVFVVOR NIG5bGNKdmS3Y3XzJIFxd3C2b4Ppd{BjgSCrbnjpZol1cW6pIGDUSW4h\GWpcnHkZZRqd25? MWexO|Y5PDBzOB?=
LPS-stimulated RAW264.7 cells MYXGeY5kfGmxbjDBd5NigQ>? M4rMRmROW09? NIrzTopKdmirYnn0d{BPTi2tYYDwZWIhTE6DIHLpcoRqdmd? M3LZ[|E4PDB5Mke3
PC12 NV2wfZFHTnWwY4Tpc44hSXO|YYm= NHnmN4kyODBizszNxsA> NH\iSnozPCCq MlTNSG1UVw>? Ml[5TY5pcWKrdIOgOk1QUESDLTDhcoQhUDKRMj3pcoR2[2WmIHP5eI91d3irY3n0fS=> MWWxO|E2QDR3NB?=
PC3 Ml2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j0[VIxKM7:TR?= MWG0PEBp M{jrOGROW09? MXLJR|UxRTBwNjFOwG0> MkOxNVY3QDZ3M{e=
LP-1 M33pSWFxd3C2b4Ppd{BCe3OjeR?= NFvYV44{ODBibl2= NGjwOHczPCCq NX;te4h7TE2VTx?= M{TtOmlv\HWlZYOgZZBweHSxc3nzJIJ6KGmwY4LlZZNqdmdiY3zlZZZm\CCSQWLQJIxmfmWuIHHu[EBz\WS3Y3nu[{BO[2xvMTDwdo91\WmwIHzleoVt MWixOVk2QDV6OR?=
ES6 NXXjOmZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HGVGlEPTB;MD6wNVMxPiEQvF2= NEDnTo9USU6JRWK=
A101D MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEOyO|kh|ryP M121OXNCVkeHUh?=
OCUB-M Mmf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPyVoRKSzVyPUCuNFM4OzdizszN MmniV2FPT0WU
LB2518-MEL MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y5[mlEPTB;MD6wN|c3KM7:TR?= NGP6dHpUSU6JRWK=
SH-4 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMESzNUDPxE1? NUDRUWQ4W0GQR1XS
KNS-42 NHzVbpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEewTGJKSzVyPUCuNFQ1PDFizszN MX;TRW5ITVJ?
DSH1 NX30ZmI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETwR41KSzVyPUCuNFUzQDlizszN NVTzTmtYW0GQR1XS
NTERA-S-cl-D1 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\ETWM2OD1yLkC1O|czKM7:TR?= MUjTRW5ITVJ?
D-542MG NYnkSYw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjKTWM2OD1yLkC1PVU4KM7:TR?= NWD3XXBpW0GQR1XS
KS-1 MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\YTWM2OD1yLkC2OFU5KM7:TR?= Mn72V2FPT0WU
BL-41 NIjEO5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzkTWM2OD1yLkC2PVQ4KM7:TR?= M{n4VnNCVkeHUh?=
LXF-289 NUfVO5k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEewOlYh|ryP MXfTRW5ITVJ?
D-247MG MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEeyNFkh|ryP NEnCSHBUSU6JRWK=
MMAC-SF MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTyTWM2OD1yLkC3NlY5KM7:TR?= MWnTRW5ITVJ?
CP66-MEL NYCxOW5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH2bIlKSzVyPUCuNFc2KM7:TR?= MXPTRW5ITVJ?
LB771-HNC MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEiwN|Yh|ryP MmrDV2FPT0WU
no-10 NV7JeZNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEi5NFkh|ryP MoHEV2FPT0WU
A388 MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jlTWlEPTB;MD6wPVA3PSEQvF2= M13WU3NCVkeHUh?=
OPM-2 NITRWotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHi0TFBKSzVyPUCuNVA1PzRizszN NHTTPZZUSU6JRWK=
OVCAR-4 NWW4Oml1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMUC5N|gh|ryP MWrTRW5ITVJ?
HOP-62 NHzHPJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMUC5OFkh|ryP MlXKV2FPT0WU
ML-2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXETWM2OD1yLkGxPFA3KM7:TR?= MWnTRW5ITVJ?
UACC-257 M4XNTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXVUHBKSzVyPUCuNVE6OjdizszN M1T6b3NCVkeHUh?=
NEC8 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTYTWM2OD1yLkGxPVk2KM7:TR?= NV7WbnNWW0GQR1XS
ONS-76 NHH2TYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;WeWlEPTB;MD6xNlk{PSEQvF2= M{f4Z3NCVkeHUh?=
KE-37 NV20OGI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\pdWlEPTB;MD6xN|I4QCEQvF2= NU\JbY1FW0GQR1XS
HT-144 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7RTpl5UUN3ME2wMlE{QDl3IN88US=> M4W3RnNCVkeHUh?=
LB2241-RCC NWr3b2NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfVTpRIUUN3ME2wMlE1OjR5IN88US=> M3myU3NCVkeHUh?=
TE-5 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULBNJV1UUN3ME2wMlE1Ojd6IN88US=> NVXCNY5UW0GQR1XS
KINGS-1 NIrTWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLmPFlKSzVyPUCuNVQ4QSEQvF2= MVPTRW5ITVJ?
NCI-H69 NUTm[YF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPnTWM2OD1yLkG1NVQyKM7:TR?= NWXNSGpLW0GQR1XS
CAS-1 NVzaTWFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVywV5ltUUN3ME2wMlE2PDh{IN88US=> MlXFV2FPT0WU
D-263MG NHnzb4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DDc2lEPTB;MD6xOlAxPiEQvF2= MkTZV2FPT0WU
A253 NXvxVGhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3vTWM2OD1yLkG2NVI5KM7:TR?= MmLzV2FPT0WU
PF-382 NEDmTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1uzdWlEPTB;MD6xOlcxPiEQvF2= MYLTRW5ITVJ?
CESS M1i2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r1O2lEPTB;MD6xO|A3KM7:TR?= MmXkV2FPT0WU
MZ2-MEL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLuTWM2OD1yLkG3OVU6KM7:TR?= NXS5XIVoW0GQR1XS
HEL MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvvTWM2OD1yLkG4OVE4KM7:TR?= MoGwV2FPT0WU
D-392MG M2PZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMUmxNVUh|ryP MkmxV2FPT0WU
SK-LMS-1 NG[zXXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMUmzNFMh|ryP NXHaZoptW0GQR1XS
GI-ME-N NFjOS5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofhTWM2OD1yLkG5N|A3KM7:TR?= NHzvN2dUSU6JRWK=
LB831-BLC NHzMVZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv4VHZ{UUN3ME2wMlE6OzRizszN Mn7ZV2FPT0WU
DU-4475 NUnuSZg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvHTWM2OD1yLkG5OlU5KM7:TR?= NUO1[Gk2W0GQR1XS
IST-SL1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PWSGlEPTB;MD6yNFA6PCEQvF2= M33lbXNCVkeHUh?=
GAK MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH62NotKSzVyPUCuNlA2OzRizszN M3HD[HNCVkeHUh?=
EW-1 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;DXWVVUUN3ME2wMlIyODR5IN88US=> NV;HSZQxW0GQR1XS
LAMA-84 M3;pfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j2fWlEPTB;MD6yNVg2OSEQvF2= MYDTRW5ITVJ?
SK-UT-1 MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;NTo9YUUN3ME2wMlIzODR7IN88US=> MoK0V2FPT0WU
VA-ES-BJ NV;nfVRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTITWM2OD1yLkKyNlU4KM7:TR?= MmTqV2FPT0WU
ACN NX3ibpVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjTWXk3UUN3ME2wMlIzPjN6IN88US=> MVHTRW5ITVJ?
SK-PN-DW NXfvTXVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HaNWlEPTB;MD6yN|E6KM7:TR?= NX7adlhyW0GQR1XS
HD-MY-Z M3\q[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULXbY1OUUN3ME2wMlI{OzB|IN88US=> M2D6N3NCVkeHUh?=
LB373-MEL-D NGS4SVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DITmlEPTB;MD6yOFE6QCEQvF2= MXnTRW5ITVJ?
COLO-829 NWrtW25GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrBTWM2OD1yLkK0NlU4KM7:TR?= NWDRdIhjW0GQR1XS
ES8 NGOwVVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC5cHlKSzVyPUCuNlQ4PjNizszN MWjTRW5ITVJ?
RXF393 NILTfYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nBTGlEPTB;MD6yOVAyPSEQvF2= NYnUdlZmW0GQR1XS
TK10 MlfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMkW0N|Uh|ryP NGnPN5ZUSU6JRWK=
LOUCY NF\OepVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDXTWM2OD1yLkK1OFU3KM7:TR?= NVTuRVZyW0GQR1XS
MZ7-mel NXj0Onp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMk[zO|Qh|ryP MofDV2FPT0WU
CP67-MEL M4jlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHGUIRKSzVyPUCuNlY4OyEQvF2= Mnr3V2FPT0WU
C2BBe1 M4nM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn4TWM2OD1yLkK3PVA4KM7:TR?= M2XwRnNCVkeHUh?=
K052 NUW1[JFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvFTWM2OD1yLkK4PVkh|ryP NWXlS2toW0GQR1XS
MOLT-16 NFLYRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoC2TWM2OD1yLkK5OVI1KM7:TR?= MonoV2FPT0WU
KNS-81-FD M32yb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3IVFBoUUN3ME2wMlMxOzJ|IN88US=> M2DZPHNCVkeHUh?=
CMK MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwM{GxNkDPxE1? M33H[HNCVkeHUh?=
LAN-6 NUHM[2RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHvTWM2OD1yLkOxN{DPxE1? NFjROW9USU6JRWK=
KLE NWPKZ|RDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LiZ2lEPTB;MD6zNVMxPiEQvF2= NVvr[mk2W0GQR1XS
NCCIT MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXiWo9KSzVyPUCuN|E4QDNizszN M17lTXNCVkeHUh?=
HH Ml65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwM{K4PVch|ryP NIfpcmVUSU6JRWK=
TE-8 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\se45KSzVyPUCuN|QzPzlizszN M1\uTHNCVkeHUh?=
GDM-1 NHS1SohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHrfm9{UUN3ME2wMlM2OTB2IN88US=> MnjyV2FPT0WU
NCI-H747 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfUTWM2OD1yLkO3NVA{KM7:TR?= NWPsTlF2W0GQR1XS
NCI-H1092 NVzRfWtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfnTWM2OD1yLkO4PFQ1KM7:TR?= MnLWV2FPT0WU
8-MG-BA M1rwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvlTWM2OD1yLkO5PFM4KM7:TR?= NHj2XmxUSU6JRWK=
NB17 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWexVY52UUN3ME2wMlQzQTdizszN M4rPbnNCVkeHUh?=
LC4-1 M3;yTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\FeoRKSzVyPUCuOFM3ODdizszN NV\SZm1DW0GQR1XS
TE-1 MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYKxUodHUUN3ME2wMlQ2OTF7IN88US=> NWfsTVhwW0GQR1XS
KALS-1 NHjHSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwNE[1PFQh|ryP Mn3NV2FPT0WU
CCRF-CEM NHTzTnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf2cIlwUUN3ME2wMlQ4Pjd2IN88US=> MYHTRW5ITVJ?
OS-RC-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXhbHBKSzVyPUCuOFc6PzJizszN M1e3b3NCVkeHUh?=
A704 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwNEi2PVIh|ryP NHzjRYJUSU6JRWK=
BB49-HNC NWTsSYR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwNEmwPVYh|ryP Ml7PV2FPT0WU
EVSA-T MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwNEm5NVEh|ryP MnfOV2FPT0WU
Mo-T MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHqdldSUUN3ME2wMlUyPzZ{IN88US=> MlPPV2FPT0WU
MONO-MAC-6 M4\Rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELQbo9KSzVyPUCuOVM3OTFizszN MYrTRW5ITVJ?
BB65-RCC M3jL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3oNnJbUUN3ME2wMlU3QDFzIN88US=> NXG5Vmh4W0GQR1XS
NCI-H1882 M2fwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTYTWM2OD1yLkW5NFM3KM7:TR?= M3zMVHNCVkeHUh?=
TE-9 NV\jS5FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjvTWM2OD1yLk[xNFM{KM7:TR?= NV6xSJl5W0GQR1XS
NCI-H2126 NYTsR5BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HkR2lEPTB;MD62NlY3QSEQvF2= MmfZV2FPT0WU
SF268 NY\xc4h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwNkW2OFEh|ryP MkHvV2FPT0WU
SW872 NUmwc4tpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwNkW3Nlkh|ryP MV3TRW5ITVJ?
LS-513 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHadGxKSzVyPUCuOlY4PTFizszN Ml3GV2FPT0WU
NCI-H1355 NXf2PIRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHKdGtKSzVyPUCuOlg3OTlizszN MlfpV2FPT0WU
BL-70 NEHDV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor4TWM2OD1yLk[5N|g5KM7:TR?= NYXqbJI{W0GQR1XS
NCI-SNU-5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwNkm1OFUh|ryP MVvTRW5ITVJ?
SNU-C2B NYLvTGlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2C2U2lEPTB;MD63NFc{QSEQvF2= NV62SlF7W0GQR1XS
GB-1 NVTmV2l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjEc49YUUN3ME2wMlczOTJ2IN88US=> NIHYVXdUSU6JRWK=
CTB-1 NXG3e5hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwN{e5OVUh|ryP MlvXV2FPT0WU
Becker MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TjeWlEPTB;MD63PVYzOSEQvF2= NGfKWYxUSU6JRWK=
KM12 MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jY[mlEPTB;MD64OVQ3PiEQvF2= NUC0[m83W0GQR1XS
ES7 NIDqe29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwOEm2OUDPxE1? NI\UN2VUSU6JRWK=
COLO-684 NYOwfYtyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwOUC2OVgh|ryP M2TWSHNCVkeHUh?=
HCC2998 M2frZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrtTWM2OD1yLkmzPFU1KM7:TR?= M3e2cXNCVkeHUh?=
TE-10 M{fVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzWbZlvUUN3ME2wMlk3PDNizszN MkPZV2FPT0WU
SF126 Mmr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vibmlEPTB;MD65PFk4OSEQvF2= NIexeIJUSU6JRWK=
EKVX NVjZblVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXqOXVDUUN3ME2xMlA{PDR{IN88US=> Mn[5V2FPT0WU
KARPAS-45 MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Tvc2lEPTB;MT6wOFAyPiEQvF2= MUjTRW5ITVJ?
KGN NVH0VXNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTFwMEWwOFUh|ryP NWDOO4E3W0GQR1XS
ES1 M1fDfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfRO5k4UUN3ME2xMlA4QTJzIN88US=> NIXzRXVUSU6JRWK=
L-540 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTFwMUG4N|kh|ryP M{fPXnNCVkeHUh?=
KURAMOCHI NYHZXHhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33mSGlEPTB;MT6xNlM4PCEQvF2= MkTNV2FPT0WU
LU-65 NWn5VHFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXVdVdKSzVyPUGuNVI4PTNizszN MWTTRW5ITVJ?
MFH-ino MnntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\r[Jh2UUN3ME2xMlE4PTBzIN88US=> NYn2TXhkW0GQR1XS
NCI-H23 NIX1bGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkftTWM2OD1zLkKwOFEh|ryP NEiwfVZUSU6JRWK=
IA-LM NFjibIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2noO2lEPTB;MT6yOFEyPiEQvF2= MoHCV2FPT0WU
PSN1 NFfrOnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:zNoZKSzVyPUGuNlcxOTZizszN NGTEXnFUSU6JRWK=
NCI-H719 MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7UV2lVUUN3ME2xMlI4PDFzIN88US=> NXfUWpJWW0GQR1XS
SW684 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWL6VIFNUUN3ME2xMlI5PjV7IN88US=> MYDTRW5ITVJ?
HCE-4 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPWO4ZKSzVyPUGuN|AzOjFizszN NITXXYpUSU6JRWK=
EW-16 M{DYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\CTWM2OD1zLkOxN|Q4KM7:TR?= NX3J[JZUW0GQR1XS
NCI-H128 NVi5dpl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTFwM{W4NVQh|ryP M1f1fXNCVkeHUh?=
HC-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf6TWM2OD1zLkO4NVch|ryP NX\YVY5[W0GQR1XS
IST-MES1 NFzDRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFwNECyNFgh|ryP M1rp[XNCVkeHUh?=
Raji MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\vSItGUUN3ME2xMlQyQDVizszN M1HW[HNCVkeHUh?=
DMS-114 NIfJVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnubZdKSzVyPUGuOFQ2OzlizszN MYXTRW5ITVJ?
GI-1 MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTFwNEexN|Eh|ryP NHvTOItUSU6JRWK=
NCI-H2081 M3jnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrqO412UUN3ME2xMlU2OTl4IN88US=> MmfKV2FPT0WU
LC-1F MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTFwNUWxPVgh|ryP M3PZZ3NCVkeHUh?=
NCI-H2227 M1H2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHxXGlKSzVyPUGuOlE2PjFizszN NFz0U2RUSU6JRWK=
D-502MG MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnYfY1qUUN3ME2xMlY4OjFzIN88US=> MWnTRW5ITVJ?
NCI-H2141 NVvtcIRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwNkezNVch|ryP MXPTRW5ITVJ?
LS-411N M4LZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXv[pkzUUN3ME2xMlY6QDB5IN88US=> MoDOV2FPT0WU
SU-DHL-1 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFwN{GyPFEh|ryP NVLNSYpkW0GQR1XS
BB30-HNC MmXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXGV4hKSzVyPUGuO|I3QDVizszN M2PkWHNCVkeHUh?=
TE-15 NYHxOG92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfVdZZ3UUN3ME2xMlkzOzd|IN88US=> MVXTRW5ITVJ?
JVM-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnifHVKSzVyPUGuPVM6ODRizszN Mkm1V2FPT0WU
IST-SL2 NHrRNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\peIZ4UUN3ME2yMlAyOjV{IN88US=> M3Xw[HNCVkeHUh?=
EW-18 NX7wTVhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\kXId7UUN3ME2yMlAzOzN5IN88US=> Mni5V2FPT0WU
DJM-1 M4\z[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknjTWM2OD1{LkCyOVUzKM7:TR?= NV72b3Y2W0GQR1XS
no-11 M3fFdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJwMEOxNFQh|ryP MmfZV2FPT0WU
QIMR-WIL M3HZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTxTWM2OD1{LkG2O|YzKM7:TR?= M2DZb3NCVkeHUh?=
MC-CAR M1LNTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFKxOWVKSzVyPUKuNlI6PSEQvF2= MnnFV2FPT0WU
KM-H2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHnd5luUUN3ME2yMlI6ODR|IN88US=> M4rR[nNCVkeHUh?=
ECC12 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;i[oRnUUN3ME2yMlM4QTRizszN MVrTRW5ITVJ?
HCE-T NWG0XIZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnKTWM2OD1{LkS0PFg{KM7:TR?= MonjV2FPT0WU
MFM-223 NXGzXlM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwNUC4O|Eh|ryP MmS2V2FPT0WU
SW982 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwNUG0PEDPxE1? MnvEV2FPT0WU
KG-1 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEP4eIFKSzVyPUKuPFg4QTFizszN M1viTHNCVkeHUh?=
ES4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXGTWM2OD1|LkC2NVEyKM7:TR?= NUDDRohIW0GQR1XS
SCC-3 NGC0PYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvjcIh1UUN3ME2zMlExQDR6IN88US=> M3zHb3NCVkeHUh?=
RH-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPFNHZKSzVyPUOuN|g4PDhizszN NGnuXlZUSU6JRWK=
NCI-H748 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVixfWpFUUN3ME2zMlQ1OjZ4IN88US=> M3nS[HNCVkeHUh?=
HCC2218 M37ZTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPHZ2NKSzVyPUOuOFY6OzdizszN MlH4V2FPT0WU
MEG-01 MoXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTNwNUm2PEDPxE1? MmLLV2FPT0WU
NB12 MlXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfUZW1KSzVyPUOuOVk5QDhizszN MUfTRW5ITVJ?
SNB75 NEHrWXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfwTWM2OD1|Lk[wNVA{KM7:TR?= Ml:2V2FPT0WU
KMS-12-PE NWXBV2ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS0W29nUUN3ME2zMlY4PzJ|IN88US=> NHXBZYtUSU6JRWK=
SKM-1 M2nNbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fNcWlEPTB;Mz63NVM4PiEQvF2= MVHTRW5ITVJ?
COLO-320-HSR MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u5RmlEPTB;Mz63OVY{PCEQvF2= MYLTRW5ITVJ?
NKM-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fTZmlEPTB;Mz63O|M4QCEQvF2= NIXTUIpUSU6JRWK=
TE-6 M1vTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nve2lEPTB;Mz65OFU3OSEQvF2= MmHqV2FPT0WU
D-336MG NEDWOYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzjTWM2OD12LkCxNVY3KM7:TR?= M3e1ZXNCVkeHUh?=
NCI-H1650 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETaepVKSzVyPUSuNVU4QTdizszN MUHTRW5ITVJ?
ES3 NIjRWZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzjNZVKSzVyPUSuN|I5OjRizszN MYPTRW5ITVJ?
YT MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\wVWpKSzVyPUSuN|U1OjRizszN MkTFV2FPT0WU
ES5 NVjxbGpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPHfI5KUUN3ME20MlQxOjV3IN88US=> NFXIe4NUSU6JRWK=
LB647-SCLC NF;6OI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1O1RmlEPTB;ND61OlMxQCEQvF2= NWi4PYVSW0GQR1XS
HAL-01 NYPuNXJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTRwNUewN|Qh|ryP NXHvVmdiW0GQR1XS
LP-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnZTWM2OD12LkeyN|cyKM7:TR?= MVTTRW5ITVJ?
BC-1 NVvDXIh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPocpFMUUN3ME21MlAxPDR5IN88US=> NYLScWtPW0GQR1XS
EB-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTVwMEOwOFEh|ryP MU\TRW5ITVJ?
GT3TKB NVHHT2JLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTVwMUe2OlIh|ryP Mo\lV2FPT0WU
NCI-H209 M2XwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljCTWM2OD13LkG5N|UzKM7:TR?= MlHlV2FPT0WU
BT-474 M3vnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPYXnZnUUN3ME21MlI{OTB{IN88US=> MX7TRW5ITVJ?
RKO MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HkbmlEPTB;NT6yN|QzOiEQvF2= MmrsV2FPT0WU
SIMA NUG3d4RIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq1TIE4UUN3ME21MlMxPzZ3IN88US=> MX\TRW5ITVJ?
RL NFXnbWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXrN2hKSzVyPUWuN|c2PDFizszN M{K2cnNCVkeHUh?=
GCIY NW\OPXJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvYZ5FKSzVyPUWuOFczOzZizszN MXrTRW5ITVJ?
Calu-6 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDhTWM2OD13Lk[yNkDPxE1? NWPBbVRoW0GQR1XS
ALL-PO M1nK[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLNdYxKSzVyPUWuOlM4QTVizszN Mk[xV2FPT0WU
ARH-77 M2Hp[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIWzcIpKSzVyPUWuOlcxQDdizszN MYHTRW5ITVJ?
A4-Fuk NG\CR4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\OTWM2OD14LkC4NVE5KM7:TR?= NGP5c3dUSU6JRWK=
NCI-H1581 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\NTWM2OD14LkKzPFQ6KM7:TR?= M1\UXnNCVkeHUh?=
HUTU-80 M3\abWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nXUmlEPTB;Nj6zOlg6PyEQvF2= MVPTRW5ITVJ?
TGW MnK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTZwNEW1PVMh|ryP NGnuWY5USU6JRWK=
SK-N-FI M{LNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTZwNEW4OVQh|ryP MoSyV2FPT0WU
U-266 NFPwdJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTZwNUG5NlYh|ryP NIfxemFUSU6JRWK=
EM-2 M2Cx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHQTWM2OD14Lk[3NFk6KM7:TR?= MUPTRW5ITVJ?
NMC-G1 MkPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnqZWh1UUN3ME22MlcyQDl3IN88US=> NWny[lVxW0GQR1XS
KASUMI-1 MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTZwOES3PFch|ryP M4HN[XNCVkeHUh?=
NALM-6 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTZwOE[3OVQh|ryP M3:zbXNCVkeHUh?=
OCI-AML2 MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;RR21KSzVyPUeuNFA{OjZizszN M2TGe3NCVkeHUh?=
SHP-77 NF7hVFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPRcW1yUUN3ME23MlIzPDNizszN MWfTRW5ITVJ?
NOMO-1 NVjzfGUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DtdWlEPTB;Nz6yOFI2PCEQvF2= NGq1d3JUSU6JRWK=
SK-N-DZ MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTdwN{GwPFkh|ryP NUPIVItOW0GQR1XS
LB1047-RCC M1\WT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7iPFNKSzVyPUeuO|IzOzFizszN Mn\hV2FPT0WU
MZ1-PC NY[4fJpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLoXG1NUUN3ME23Mlg3PTV6IN88US=> NHHKb|JUSU6JRWK=
NB10 NYLaV2tLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zKOWlEPTB;Nz65PVU2PiEQvF2= Mn3YV2FPT0WU
RL95-2 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SySGlEPTB;OD6xNFg1OiEQvF2= NEjnTmZUSU6JRWK=
OMC-1 NFrpRnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRThwNUKxPVEh|ryP MofVV2FPT0WU
D-283MED MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MormTWM2OD16LkmxO|E6KM7:TR?= NIrLVlZUSU6JRWK=
MC116 NWTjZWFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;YOWlEPTB;OD65O|k1KM7:TR?= NHnxVXVUSU6JRWK=
SJSA-1 NGD0XGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjBTWM2OD17LkC5NFkyKM7:TR?= NFXPOIZUSU6JRWK=
JiyoyeP-2003 M{H2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy5cWhEUUN3ME25MlI6OzF5IN88US=> NVfmWJpMW0GQR1XS
IST-MEL1 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LWcGlEPTB;OT63OFE6QCEQvF2= NV7BeVY{W0GQR1XS
CTV-1 M{fjNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrjeZY3UUN3ME2xNE4xQTd7IN88US=> MUnTRW5ITVJ?
NH-12 NUDwOVBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFyLkK0N|Mh|ryP NF30[IJUSU6JRWK=
CA46 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TwT2lEPTB;MUCuN|YyKM7:TR?= NUHncmxYW0GQR1XS
NCI-SNU-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPSfYFKSzVyPUGwMlQ6PjlizszN NYiydlFYW0GQR1XS
SCLC-21H Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzMc4hIUUN3ME2xNE43PTl4IN88US=> M{jUbHNCVkeHUh?=
EC-GI-10 M{HLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHNTWM2OD1zMD63NFMyKM7:TR?= MlXDV2FPT0WU
SR NV\5d2RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfvcFhKSzVyPUGxMlAyQDVizszN M4T2[3NCVkeHUh?=
NCI-H1648 MnnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETSZmNKSzVyPUGxMlA6PjVizszN NVv3cWlOW0GQR1XS
TGBC1TKB NGjyR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj4cJdsUUN3ME2xNU41OTB{IN88US=> NFzXRZlUSU6JRWK=
EW-11 MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnqTWM2OD1zMT61NVg3KM7:TR?= MnHTV2FPT0WU
SK-MM-2 M3L3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qwcGlEPTB;MUGuPFA3OSEQvF2= MXjTRW5ITVJ?
NCI-H524 MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDHTHhKSzVyPUGxMlk5OjJizszN NFyzXmVUSU6JRWK=
NOS-1 M{PPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnNTWM2OD1zMj6wN|Q2KM7:TR?= M{\Ec3NCVkeHUh?=
AM-38 NHHte2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF{LkW2N|Mh|ryP Ml7oV2FPT0WU
A498 M1vQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjmeYtVUUN3ME2xNk44ODZ7IN88US=> MVXTRW5ITVJ?
KARPAS-422 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLaVVFoUUN3ME2xNk44PDl4IN88US=> NXvodItkW0GQR1XS
LU-139 NFz6bIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vmRWlEPTB;MUKuPVAzPiEQvF2= MlLNV2FPT0WU
COR-L88 NWrXXpNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTF{LkmzPFIh|ryP NGLSc2xUSU6JRWK=
K5 Ml;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXmTWM2OD1zMj65OFYzKM7:TR?= MXrTRW5ITVJ?
NB13 NHLCUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TtSGlEPTB;MUKuPVc5OyEQvF2= MYTTRW5ITVJ?
MRK-nu-1 M17jS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTF|LkG5OUDPxE1? M{jRSXNCVkeHUh?=
MHH-NB-11 NX;nOo9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\KTWM2OD1zMz6yPVAzKM7:TR?= M4\BUnNCVkeHUh?=
KU812 MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqyTWM2OD1zMz62NVI1KM7:TR?= MlznV2FPT0WU
TE-12 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\mNFd4UUN3ME2xN{43QTl2IN88US=> NV2xZ2I5W0GQR1XS
NCI-N87 NGPoUoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfhTWM2OD1zMz63N|Yh|ryP M1LnfXNCVkeHUh?=
EB2 M3PzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nQ[WlEPTB;MUOuPFUxPSEQvF2= M2TrNXNCVkeHUh?=
DB M3rjbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjoWXN[UUN3ME2xN{46QDh3IN88US=> NWjVXZFKW0GQR1XS
697 NV61enE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLFbHIxUUN3ME2xOE41PTFzIN88US=> MlvVV2FPT0WU
MSTO-211H MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rtSmlEPTB;MUSuO|Q1QCEQvF2= M{TUXHNCVkeHUh?=
JVM-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH4SFQ6UUN3ME2xOE44PzN3IN88US=> NEDjO|RUSU6JRWK=
COLO-824 NVnFb2M{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TmRWlEPTB;MUSuO|k6PCEQvF2= M3nkV3NCVkeHUh?=
BC-3 NXL6T2FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULDUmpWUUN3ME2xOU4{QThizszN MWXTRW5ITVJ?
BOKU MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\TTWM2OD1zNT65OlA5KM7:TR?= NUjiXWd2W0GQR1XS
GOTO M2ftZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Ww[WlEPTB;MU[uPVYyPyEQvF2= NXL4dGJEW0GQR1XS
HCC2157 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn72TWM2OD1zNz60O|U2KM7:TR?= M2jBbnNCVkeHUh?=
LS-1034 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C3WWlEPTB;MUeuOlgyQCEQvF2= MYfTRW5ITVJ?
CAL-148 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnWN2hqUUN3ME2xO{46Pzl4IN88US=> NI\sfFZUSU6JRWK=
MOLT-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4qzOGlEPTB;MUiuPFIxQCEQvF2= M1jLO3NCVkeHUh?=
Daudi MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C5SWlEPTB;MUiuPVI{OSEQvF2= MnjqV2FPT0WU
J-RT3-T3-5 MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7lTWM2OD1zOT60NFY3KM7:TR?= NIrBU4xUSU6JRWK=
KMOE-2 NWnPXW5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTF7Lk[0PFIh|ryP MYLTRW5ITVJ?
HL-60 NVrRNFVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q2N2lEPTB;MkCuNVk3PSEQvF2= NILtZYlUSU6JRWK=
P31-FUJ NXPxWYo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDaUXFKSzVyPUKwMlQ4PTNizszN NXLxRmpoW0GQR1XS
IM-9 M4PnTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJyLk[yNlQh|ryP M13zd3NCVkeHUh?=
HDLM-2 NU\lTpE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n5XGlEPTB;MkCuPFgzOSEQvF2= NHvCendUSU6JRWK=
NCI-H1304 M1y2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\XeJBKSzVyPUKxMlA{OTFizszN MXzTRW5ITVJ?
NCI-H345 MnjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrpSWZKSzVyPUKxMlA3PDNizszN NYLpWFRuW0GQR1XS
RPMI-6666 NFK0UoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVryWIxoUUN3ME2yNU4{PjB{IN88US=> NYSzVXN4W0GQR1XS
GR-ST MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1i2T2lEPTB;MkGuOFE4KM7:TR?= MXPTRW5ITVJ?
CHP-126 M4nXNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHZelhHUUN3ME2yNU43OThzIN88US=> NXLrXFZUW0GQR1XS
EHEB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fpbmlEPTB;MkGuOlc{OSEQvF2= Mln5V2FPT0WU
CPC-N MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInMfIhKSzVyPUK0MlAzODFizszN MYnTRW5ITVJ?
NB1 NXnsW|dzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTJ2Lk[5N|kh|ryP NYDJZWRDW0GQR1XS
LS-123 MnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Gxe2lEPTB;MkSuPVAyOiEQvF2= NVXkOnZCW0GQR1XS
ST486 NHPke|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3qyZWlEPTB;MkWuNVEyOyEQvF2= MmT3V2FPT0WU
NCI-H1963 M122S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPWTWM2OD1{Nj6wOlI{KM7:TR?= NEC4VI1USU6JRWK=
U-87-MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfwd2tKSzVyPUK2Mlc3PDRizszN MlryV2FPT0WU
COR-L279 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDC[|ZKSzVyPUK2Mlc6OjJizszN MoLhV2FPT0WU
LU-165 M3O1fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1viSWlEPTB;MkiuNFg3OSEQvF2= NVXvRoMzW0GQR1XS
COLO-800 NIHJXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TLUmlEPTB;MkiuNlk2PiEQvF2= M4nzc3NCVkeHUh?=
ETK-1 NXThS2lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn2zTWM2OD1{OD6zOFQ3KM7:TR?= NH3icpNUSU6JRWK=
LNCaP-Clone-FGC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoflTWM2OD1{OT65NlgyKM7:TR?= M3WyXHNCVkeHUh?=
SIG-M5 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TZfmlEPTB;M{CuO|k2OiEQvF2= M2n6NnNCVkeHUh?=
NB6 NX\4RotyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHXZ2pKSzVyPUOwMlk2ODNizszN M2fDO3NCVkeHUh?=
NCI-H2107 MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInCNmlKSzVyPUOxMlI{OzhizszN NWr4V5FYW0GQR1XS
SNU-C1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoW1TWM2OD1|MT6zNVI3KM7:TR?= NEjjTZZUSU6JRWK=
JAR MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULPNFl2UUN3ME2zNU4{Pzl7IN88US=> NVrreY1nW0GQR1XS
L-363 M4npTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnwSY9KSzVyPUOyMlIyPDRizszN MlizV2FPT0WU
EW-24 NH7vVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTN{LkO0O|Qh|ryP MXzTRW5ITVJ?
NB69 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfCTWM2OD1|Mz62OFU1KM7:TR?= Ml3BV2FPT0WU
EW-13 NWCxZnU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj4TpZZUUN3ME2zN{45QTZ7IN88US=> NV7hfHZHW0GQR1XS
Ramos-2G6-4C10 M3vSOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\tTWM2OD1|ND6yPVk{KM7:TR?= NVjvVFVEW0GQR1XS
TE-11 NYLkTFY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\6dWlEPTB;M{SuOFgzOiEQvF2= MnLnV2FPT0WU
L-428 MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTN2Lke1N|Yh|ryP M{LVSHNCVkeHUh?=
KP-N-YN MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LIb2lEPTB;M{SuPVA2PyEQvF2= NI\FXGlUSU6JRWK=
CGTH-W-1 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne0TWM2OD1|Nj65NFQ5KM7:TR?= MUnTRW5ITVJ?
K-562 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrnTWM2OD1|Nz6wPFY1KM7:TR?= Mnj0V2FPT0WU
NCI-H1299 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfNc|VzUUN3ME2zPE4yPjB|IN88US=> NEjISlNUSU6JRWK=
RCC10RGB NYP1Zm8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTN6LkKwPFMh|ryP NH;oc3hUSU6JRWK=
NCI-SNU-16 NUP3fYVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTN6LkW2OVMh|ryP M2LT[3NCVkeHUh?=
LC-2-ad MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\kbmlEPTB;M{muOFM{PyEQvF2= NITWZ4hUSU6JRWK=
MHH-PREB-1 NFH0fGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3zcVh1UUN3ME2zPU44Ozh6IN88US=> MXTTRW5ITVJ?
NCI-H64 M{HaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG4VHpKSzVyPUSwMlA6PDhizszN MkTxV2FPT0WU
LB996-RCC NWnwUnZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXHeVZKSzVyPUSwMlg4OTZizszN Ml\tV2FPT0WU
DEL NYHnbWJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzMV|hKSzVyPUSxMlQ1ODVizszN MUPTRW5ITVJ?
MLMA MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3rPVNNUUN3ME20NU44PTl3IN88US=> NFnCNXpUSU6JRWK=
SBC-1 NF60SVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlf2TWM2OD12Mj6xPFA3KM7:TR?= MXfTRW5ITVJ?
MPP-89 NU\BZ5pCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LZSmlEPTB;NEKuOVg4PSEQvF2= NWnqd|loW0GQR1XS
MV-4-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LES2lEPTB;NEKuPVA3PyEQvF2= NYDMU5pqW0GQR1XS
EoL-1- MlrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3i1cmlEPTB;NESuNVU3QCEQvF2= NVTad3E2W0GQR1XS
CW-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTR2LkizOFIh|ryP MV\TRW5ITVJ?
HT NFf0NJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfmR3VKSzVyPUS1MlcxODdizszN MojEV2FPT0WU
SW954 NYPuT2Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHMT4tKSzVyPUS3MlQyOjhizszN M3HZSXNCVkeHUh?=
A3-KAW M4T4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnvOHhUUUN3ME20PU45ODZzIN88US=> NWW3fldFW0GQR1XS
TC-YIK M{PNcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PlXGlEPTB;NUCuNFM3OyEQvF2= NFLlblBUSU6JRWK=
SW962 NIrHVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES4Z3FKSzVyPUW0Mlg{PTdizszN NXLDPWRVW0GQR1XS
KP-N-RT-BM-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHxTYg1UUN3ME21Ok43PjN6IN88US=> M3i4cnNCVkeHUh?=
NCI-H1395 NFztcpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\ZUmlEPTB;NUiuPFE4OiEQvF2= NEK3cVhUSU6JRWK=
RPMI-8402 NX3MeGhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXDd|NKSzVyPUW4Mlk2OjZizszN NEfpZYlUSU6JRWK=
SCH NHXXZVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTZyLkm2N|gh|ryP M2nsXnNCVkeHUh?=
NCI-H2196 NYXCOXlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NImy[|ZKSzVyPU[xMlI{OSEQvF2= M2D4OXNCVkeHUh?=
LOXIMVI NHnrd4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPyXXpZUUN3ME22NU45OjZ4IN88US=> MXPTRW5ITVJ?
TGBC24TKB M4TT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T1e2lEPTB;NkKuNVQ6OSEQvF2= M1KwT3NCVkeHUh?=
SK-MEL-2 NWnsTmk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTZ|Lkm4PVIh|ryP NHTIT5hUSU6JRWK=
U-698-M NFzYV4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\MTGlEPTB;NkiuOVY5PyEQvF2= NVTKV3dQW0GQR1XS
NCI-H1522 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTZ7LkCwOFch|ryP NXnHXGdXW0GQR1XS
UACC-812 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjBUXhKSzVyPU[5MlUzODlizszN NH;wOYdUSU6JRWK=
MHH-CALL-2 NYrXRVFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXW5O21iUUN3ME23NE4xPiEQvF2= MoSwV2FPT0WU
NB5 NXSwcWRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nqTGlEPTB;N{CuN|Q3QCEQvF2= M3vpTXNCVkeHUh?=
KARPAS-299 M{jhRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[4TWM2OD15MD60OFQ4KM7:TR?= NWf4VGsxW0GQR1XS
NCI-H1694 NIOzOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\QTWlEPTB;N{GuNFMzKM7:TR?= MoK1V2FPT0WU
NCI-H82 Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTdzLkm1NFch|ryP MX;TRW5ITVJ?
SCC-15 MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XJNGlEPTB;N{KuN|Qh|ryP M2jwZ3NCVkeHUh?=
NCI-H1436 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTd{Lke0OVYh|ryP NI\ofpJUSU6JRWK=
ATN-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jqZ2lEPTB;N{SuOVA2KM7:TR?= NEi3emhUSU6JRWK=
RPMI-8866 Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTd2Lke1NFkh|ryP M1jRfnNCVkeHUh?=
HCC1599 MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nKR2lEPTB;N{SuPFc{OiEQvF2= M{fuWHNCVkeHUh?=
NCI-H1155 NVHOWGtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHqOI5OUUN3ME23OE46OzZ5IN88US=> NVr3T|ZIW0GQR1XS
DOHH-2 M2DnN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD0cHlqUUN3ME23OE46PTF2IN88US=> MVjTRW5ITVJ?
SK-NEP-1 NEn2bXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTZTWM2OD15NT6wO|U1KM7:TR?= M3K1dHNCVkeHUh?=
HCC1187 NViybHBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n4SGlEPTB;N{euOlEzOiEQvF2= M1robHNCVkeHUh?=
NCI-H322M NX;wd|h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO5S2RKSzVyPUe4MlM4ODlizszN MX;TRW5ITVJ?
NCI-H526 NWnLd4ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTd6LkW4O|ch|ryP Mm\hV2FPT0WU
NCI-H2171 M4nJXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L5RmlEPTB;N{muOFE{PiEQvF2= Ml2xV2FPT0WU
COLO-668 NWD1Z5U3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3WzNWlEPTB;OEGuOVg5PCEQvF2= M3:0ZXNCVkeHUh?=
RS4-11 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\CTWM2OD16Mj6yOVA2KM7:TR?= M4LZZ3NCVkeHUh?=
NCI-H716 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTh{LkmwO|Uh|ryP NEGyR21USU6JRWK=
LU-134-A M4TiTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjIN4FFUUN3ME24N{4yOzVzIN88US=> M1v5ZnNCVkeHUh?=
RPMI-8226 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTh2LkKxNFch|ryP NXTo[XVZW0GQR1XS
KY821 Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\HTWM2OD17MT62OVUyKM7:TR?= MYTTRW5ITVJ?
ECC4 NYLONFI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPVT5VKSzVyPUmzMlgzPjlizszN MlLQV2FPT0WU
EW-3 Mn24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\Jfo9KSzVyPUm0MlkxQDFizszN NVLnXJh[W0GQR1XS
NB7 MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q0ZmlEPTB;OUWuO|c5PiEQvF2= NW\LPIY2W0GQR1XS
NCI-H720 NWXI[nRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTl6LkSwOlEh|ryP MnPWV2FPT0WU
NCI-H446 MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LWeGlEPTB;OUmuO|U5QCEQvF2= MWHTRW5ITVJ?
NCI-H889 M4XuTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTiO4lKUUN3ME2xNFQvOjR{IN88US=> M{fmU3NCVkeHUh?=
EW-22 NVnqVotLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknITWM2OD1zME[uNVkh|ryP NU\xbZVFW0GQR1XS
BV-173 NGrsdY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jkVmlEPTB;MUC4MlczQCEQvF2= MlrJV2FPT0WU
WSU-NHL M3rhdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEm2TFdKSzVyPUGwPU43PzFizszN NW\XeZJTW0GQR1XS
MN-60 M1m3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDGdWlKSzVyPUGwPU43QSEQvF2= M2DPXHNCVkeHUh?=
DG-75 M{TpdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULuWI5UUUN3ME2xNVMvOzV{IN88US=> MWHTRW5ITVJ?
DMS-79 NX\CU4UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HpZ2lEPTB;MUG3MlM5OiEQvF2= NYfzblVIW0GQR1XS
SK-MEL-1 NEjJc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjocHVKSzVyPUGxPE4xODlizszN M4PVb3NCVkeHUh?=
DMS-153 NUXvVIttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnqwTWM2OD1zMkGuO|Q2KM7:TR?= MUTTRW5ITVJ?
NCI-H510A M1uyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTF{Nz6zNkDPxE1? MWjTRW5ITVJ?
BE-13 M1foWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTF|ND6wOFQh|ryP MWrTRW5ITVJ?
KP-N-YS NGLXTIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXQR4hLUUN3ME2xN|kvPzN4IN88US=> NYHtZY1HW0GQR1XS
SUP-T1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF2Mz63NFgh|ryP M1jaN3NCVkeHUh?=
EW-12 NV7KT21IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfJcWhKSzVyPUG0OE43QTlizszN NW\W[lF{W0GQR1XS
NB14 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTF2Nz6wPFIh|ryP M1K0e3NCVkeHUh?=
MDA-MB-134-VI NFrtZ3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXrTWM2OD1zNEiuNlY5KM7:TR?= MUDTRW5ITVJ?
NCI-H1770 Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj1fHZKSzVyPUG1Ok4zPzlizszN MoLyV2FPT0WU
TUR MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjHTWM2OD1zNkeuPFch|ryP NGH0e2xUSU6JRWK=
NCI-H1417 NWPEfldFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTF6MD6zN|Eh|ryP M1LSenNCVkeHUh?=
IMR-5 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfJUJFKUUN3ME2xPFEvPTdzIN88US=> M2fnXHNCVkeHUh?=
NCI-H226 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;UNGlEPTB;MUi4Mlg3PiEQvF2= MW\TRW5ITVJ?
NCI-H187 NVH1Z5NQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\VUJdPUUN3ME2xPVAvODZ2IN88US=> M3u2WHNCVkeHUh?=
SF539 Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvUbWljUUN3ME2xPVIvPzJ6IN88US=> NUThWY8{W0GQR1XS
TALL-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn6TWM2OD1zOUiuN|A1KM7:TR?= NHLj[3JUSU6JRWK=
TE-441-T MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HRd2lEPTB;MUm5Mlc{QSEQvF2= Ml\HV2FPT0WU
REH NYfTeI4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDqTWM2OD1{M{[uOlI3KM7:TR?= NETUeG5USU6JRWK=
MS-1 M1frcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPKcVBKSzVyPUKzPU4yOjFizszN NEXzVolUSU6JRWK=
THP-1 NXvM[opPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH36TnBKSzVyPUK2OE44OzhizszN MYnTRW5ITVJ?
NCI-H1838 M3PNPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHiTWM2OD1{N{GuOFU3KM7:TR?= M2HLe3NCVkeHUh?=
P30-OHK NHXDW2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjyNGNKSzVyPUK4N{45PDdizszN MlnRV2FPT0WU
C8166 NXu0OG11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rUZ2lEPTB;M{S1MlM{QCEQvF2= M1rCXnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Measurement of inhibitory activities of MG-132 against 20S proteasome The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.

細胞アッセイ:

[3]

細胞株 KIM-2, HC11, and ES
濃度 Dissolved in DMSO, final concentrations ~25 μM
反応時間 24, and 48 hours
実験の流れ

Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.

動物実験:

[7]

動物モデル Male mdx (C57BL/10ScSn DMD mdx) mice
製剤 Dissolved in DMSO, and diluted in PBS
投薬量 ~10 μg/kg/day
投与方法 Injection

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MG-132 SDF
分子量 475.62
化学式

C26H41N3O5

CAS No. 133407-82-6
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 95 mg/mL (199.73 mM)
Ethanol 95 mg/mL (199.73 mM)
Water <1 mg/mL
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate

文献中の引用 (46)

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related プロテアソーム 阻害剤

  • VR23

    VR23は1種の有効なプロテアソーム抑制剤で、トリプシン様プロテアソーム(trypsin-like proteasomes)、キモトリプシン様プロテアソーム(chymotrypsin-like proteasomes)とカスパーゼ様プロテアソーム(caspase-like proteasomes)に作用するIC50値は1 nM、50-100 nMと 3 μMそれぞれに分かれます。

  • Calpeptin

    Calpeptinは1種の有効的で、細胞浸透性のカルパイン( calpain)抑制剤で、カルパインI(豚赤血球)、カルパインII (豚腎臓)、パパイン(Papain)とカルパインI(人血小板)に対するID50値は52 nM、34 nM、138 nMと40 nMそれぞれに分かれます。

  • Marimastat (BB-2516)

    Marimastat (BB-2516)は1種の広範囲に使用されるマトリックスメタロプロテアーゼ(MMP)抑制剤で、MMP-9、MMP-1、MMP-2、MMP-14とMMP-7に作用する IC50値は3 nM、5 nM、6 nM、9 nMと13 nMそれぞれに分かれます。臨床3期。

  • Ledipasvir (GS5885)

    Ledipasvir(GS5885)は1種のHCV NS5Aポリメラーゼ(polymerase)抑制剤で、C型肝炎ウイルス感染の治療に使用します。

  • Bortezomib (PS-341)

    Bortezomib (PS-341)は、強力なプロテアソーム阻害剤で、Kiが0.6nMです。

  • Carfilzomib (PR-171)

    Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM.

  • Ixazomib (MLN2238)

    Ixazomib (MLN2238)は窒素端加帽の二ペプチドロイシンホウ酸で、20Sプロテアソームのカイモトリプシン類(β5)加水分解部位を抑制、IC50が3.4nM、Ki値が0.93nM。

    Features:A first-in-class proteasome inhibitor that has improved pharmacokinetics (PK), pharmacodynamics(PD), and antitumor activity in preclinical studies.

  • ONX-0914 (PR-957)

    ONX-0914(PR-957)は、恒常的プロテアソームのための最小限の交差反応性を持つ強力かつ選択的な免疫プロテアソームの阻害剤です。

    Features:The first highly selective, small molecule inhibitor of the immunoproteasome. Potential use in cancer and autoimmune diseases (e.g. rheumatoid arthritis, inflammatory bowel disease, and lupus).

  • MLN9708

    MLN9708は二代目経口生物の有効性にプロテアソーム選択阻害剤で、20Sプロテアソームのカイモトリプシン類(β5)加水分解部位に作用すると、IC50が3.4nM、Ki値が0.93nMになる。

    Features:The 1st oral proteasome inhibitor in early stage clinical trials for Multiple Myeloma.

最近チェックしたアイテム

Tags: MG-132を買う | MG-132供給者 | MG-132を購入する | MG-132費用 | MG-132生産者 | オーダーMG-132 | MG-132代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ