MG-132 化学構造
分子量: 475.62

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Quality Control & MSDS

製品説明

  • Compare Proteasome Inhibitors
    Proteasome製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MG-132は、100nMのIC50によるプロテアソームの強力な阻害剤です。
ターゲット

Proteasome

IC50

100 nM [1]

In vitro試験 MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
LPS-stimulated RAW264.7 cells MVTGeY5kfGmxbjDBd5NigQ>? NVvhWpdXOjVizszN M{HYfWROW09? NYTH[HBMUW6qaXLpeJMhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDBwMTFOwG0> NIHvVJMzPDZ7N{S5Oi=>
HL-60 NF3HfmtEgXSxdH;4bYMhSXO|YYm= M4HTVVQxKM7:TR?= MV:0PEBp MXfEUXNQ M3f4O2lEPTB:MUCg{txO M{nIUFI1Pjl5NEm2
SMMC-7721 MWDDfZRwfG:6aXOgRZN{[Xl? NGHTenA1OCEQvF2= NULqUVEzPDhiaB?= MUnEUXNQ MXTJR|UxRTdwMTFOwG0> MmrvNlQ3QTd2OU[=
A-549 NVrXc5pRS3m2b4TvfIlkKEG|c3H5 MXe0NEDPxE1? M{W0WlQ5KGh? MkmwSG1UVw>? Mnm1TWM2ODxzMDFOwG0> NW\pSJE5OjR4OUe0PVY>
MCF-7 M4LLe2N6fG:2b4jpZ{BCe3OjeR?= M4foS|QxKM7:TR?= NUKxUZRyPDhiaB?= NWDh[WV1TE2VTx?= MVzJR|UxRTdwMzFOwG0> NHz2Vm0zPDZ7N{S5Oi=>
SW-480 M{X6XGN6fG:2b4jpZ{BCe3OjeR?= NIjYcXc1OCEQvF2= Mki0OFghcA>? NGjNdJNFVVOR NVTNXIRIUUN3ME20JO69VQ>? MljyNlQ3QTd2OU[=
NCI-H929 M{XBVmN6fG:2b4jpZ{BCe3OjeR?= MX6xJO69VQ>? NWXFO415PzJiaB?= MljpSG1UVw>? NIThXVJKSzVyPUCuNVch|ryP MkDWNlQ3OjVyOEi=
293T NUjxT3FRS3m2b4TvfIlkKEG|c3H5 NXLt[2lkOTBizszN M13NSVczKGh? NWG3c|RITE2VTx?= NXnvSYFTUUN3MEyyJO69VQ>? NETwUHEzPDZ{NUC4PC=>
293T NXzMNmY5TnWwY4Tpc44hSXO|YYm= NFn1O|EyOCEQvF2= M{TrdVI1KGh? NHXrcFRFVVOR NX\rRXhCVW:mZYLheIVtgSCrbnT1Z4V{KGinYYStd4hw[2tiIB?= M3X2SlI1PjJ3MEi4
HeLa NHLiUJpMcW6jc3WgRZN{[Xl? MnvWNVAh|ryP NFLhcm4yKGh? NFjWeHdFVVOR MoXwTY5lfWOnczDQRXJRKGOuZXH2ZYdmKGK7IHnubIljcXSrbnegdJJwe2Wjc3;t[UBi[3Srdnn0fS=> MYCyOFMzOTh|Mx?=
MDA-MB-231 MlzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[0[|Eh|ryP MUm3NkBp M{eyT2ROW09? M4nCWWlEPTB;MD6xPEDPxE1? M17jVVI1OTV|MkC2
MCF-7 M1y0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7X[XkyKM7:TR?= M2P4d|czKGh? MmHTSG1UVw>? NYS4N|J5UUN3ME2wMlE{KM7:TR?= MWmyOFE2OzJyNh?=
MCF10A NVzYS2pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPEUGxwOSEQvF2= NWn6UWRoPzJiaB?= MmHmSG1UVw>? NES4RldKSzVyPUCuNlkh|ryP M3vmVlI1OTV|MkC2
HEK-293 Mn;pT4lv[XOnIFHzd4F6 M{L5O|Ih[W6mIEKwJO69VQ>? MmnzNkBp MYfEUXNQ MmLITY5pcWKrdIOgR4hVNUxiYXP0bZZqfHlid3n0bEBKSzVyIH;mJFkhdk1i NV3lbFBXOjN3NEC3PVA>
Calu6 NFTzTlVHfW6ldHnvckBCe3OjeR?= NVjwVXpqOTBizszN MX2xPEBp NHL2WHlFVVOR NE[5TFhUcWewaX\pZ4FvfGy7IHHjZ5VufWyjdHXzJIZz[XSjeHnuJJBz\WO3coPvdi=> M{PkNVI{PTB4NEi2
IFN-gamma-induced RAW264.7 Mkf4SpVv[3Srb36gRZN{[Xl? NVnBTo51TE2VTx?= NWi2VWpjUW6qaXLpeJMhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDBwMEe3JO69VQ>? NY\CS40zOjJ{N{eyO|c>
IPC227F MWfDfZRwfG:6aXOgRZN{[Xl? NWr2eopiOSEQvF2= M{HJV|Q5KGh? NUi5TGN2TE2VTx?= M4mwb2lEPTB;MD6wO|ch|ryP MVqyNVkzPDV{OB?=
Hepa-1c1c7 MVnGeY5kfGmxbjDBd5NigQ>? NVvidpY5OjVizszN MmfQOkBp NGrEbHBFVVOR M2nyWGlv[3KnYYPld{BPemZ{IIDyc5RmcW5ibHX2[Yw> NXLHXmlHOjB|OUK1OFQ>
COS-7 M4ezWGN6fG:2b4jpZ{BCe3OjeR?= NVvWUINxOTBizszN NEXjdINFVVOR MkDrTWM2ODxzMDFOwG0> NEDWZ5EyQDB6OEC5Oy=>
HuH-7 MYrDfZRwfG:6aXOgRZN{[Xl? NWf5RoREOTBizszN MYXEUXNQ NF\VfpZKSzVyPEGwJO69VQ>? MorSNVgxQDhyOUe=
OCI-Ly3 NFfZfVNHfW6ldHnvckBCe3OjeR?= NH;4OVEyOCEQvF5CpC=> MVS0JIg> M4joSGROW09? M3PxNmlv\HWlZYOgbJVu[W5iSXvhdJBiSmGucHjhJJN1[WKrbHn6ZZRqd25id3n0bEBGSzVyIH;mJFEh|ryP MVGxPFAzPDFzMx?=
A2780 cDDP NV:0e5VGSXCxcITvd4l{KEG|c3H5 MlXHNlQhcA>? NIK0cJhFVVOR NIG4WoZKdmS3Y3XzJIFxd3C2b4Ppd{BjgSCrbnjpZol1cW6pIGDUSW4h\GWpcnHkZZRqd25? M1jDW|E4Pjh2MEG4
LPS-stimulated RAW264.7 cells NX3xZ41HTnWwY4Tpc44hSXO|YYm= NWjh[3V[TE2VTx?= NGO0TJdKdmirYnn0d{BPTi2tYYDwZWIhTE6DIHLpcoRqdmd? NV7xd4tIOTd2MEeyO|c>
PC12 MV\GeY5kfGmxbjDBd5NigQ>? M2H5[FExOCEQvF5CpC=> MnHpNlQhcA>? NWLhbFBbTE2VTx?= NYjkb3h{UW6qaXLpeJMhPi2RSFTBMUBidmRiSELPNk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gQ>? NV76Vpk{OTdzNUi0OVQ>
PC3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUCyNEDPxE1? NFTpbnA1QCCq NXHRdnV1TE2VTx?= MXjJR|UxRTBwNjFOwG0> MX:xOlY5PjV|Nx?=
LP-1 NWK0fGhkSXCxcITvd4l{KEG|c3H5 NESycJI{ODBibl2= NWCxdYE4OjRiaB?= MlPlSG1UVw>? NELjPJhKdmS3Y3XzJIFxd3C2b4Ppd{BjgSCrbnPy[YF{cW6pIHPs[YF3\WRiUFHSVEBt\X[nbDDhcoQhemWmdXPpcochVWOuLUGgdJJwfGWrbjDs[ZZmdA>? NYfWc3RkOTV7NUi1PFk>
ES6 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoezTWM2OD1yLkCxN|A3KM7:TR?= NXfqWI12W0GQR1XS
A101D NWrjZVl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvIUGpUUUN3ME2wMlA{Ojd7IN88US=> M{HxV3NCVkeHUh?=
OCUB-M NFLKRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7CTWM2OD1yLkCzO|M4KM7:TR?= MYPTRW5ITVJ?
LB2518-MEL NYXUPIN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD0TWM2OD1yLkCzO|Yh|ryP MkTLV2FPT0WU
SH-4 M1rpW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PnUWlEPTB;MD6wOFMyKM7:TR?= MVfTRW5ITVJ?
KNS-42 M1GySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fPemlEPTB;MD6wOFQ1OSEQvF2= NUC2OmNIW0GQR1XS
DSH1 MnrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrINlFKUUN3ME2wMlA2Ojh7IN88US=> MlzuV2FPT0WU
NTERA-S-cl-D1 M2PFe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEW3O|Ih|ryP M4P4enNCVkeHUh?=
D-542MG NI[xXZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3t[4FjUUN3ME2wMlA2QTV5IN88US=> MonwV2FPT0WU
KS-1 MlLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInjV4NKSzVyPUCuNFY1PThizszN MmjrV2FPT0WU
BL-41 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDtU2tKSzVyPUCuNFY6PDdizszN MnTwV2FPT0WU
LXF-289 NUD3WVd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XXfGlEPTB;MD6wO|A3PiEQvF2= M2rNZ3NCVkeHUh?=
D-247MG M{XQVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nG[GlEPTB;MD6wO|IxQSEQvF2= MWjTRW5ITVJ?
MMAC-SF NYTPeoFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnwTWM2OD1yLkC3NlY5KM7:TR?= MlvsV2FPT0WU
CP66-MEL M4WxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HiXWlEPTB;MD6wO|Uh|ryP M4\jbHNCVkeHUh?=
LB771-HNC Mn;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{e5c2lEPTB;MD6wPFA{PiEQvF2= MWDTRW5ITVJ?
no-10 NFLtN4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFflWXdKSzVyPUCuNFg6ODlizszN MmXZV2FPT0WU
A388 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXzTWM2OD1yLkC5NFY2KM7:TR?= M{XuUHNCVkeHUh?=
OPM-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUezeJpvUUN3ME2wMlExPDd2IN88US=> NWX1fI9lW0GQR1XS
OVCAR-4 MoXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\OS3VSUUN3ME2wMlExQTN6IN88US=> M1[wZXNCVkeHUh?=
HOP-62 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDIR4kxUUN3ME2wMlExQTR7IN88US=> MYTTRW5ITVJ?
ML-2 NHXkRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[4e5JmUUN3ME2wMlEyQDB4IN88US=> M3XDR3NCVkeHUh?=
UACC-257 Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXZOmFKSzVyPUCuNVE6OjdizszN NE\KWphUSU6JRWK=
NEC8 NVnYR2xbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzH[IIxUUN3ME2wMlEyQTl3IN88US=> NYLPTHZkW0GQR1XS
ONS-76 NHzz[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:yOGlEPTB;MD6xNlk{PSEQvF2= MnrJV2FPT0WU
KE-37 M2PzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMUOyO|gh|ryP NIjKeVRUSU6JRWK=
HT-144 MlzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\4fGlEPTB;MD6xN|g6PSEQvF2= MlP1V2FPT0WU
LB2241-RCC M3LVV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMUSyOFch|ryP MWXTRW5ITVJ?
TE-5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj6bmRKSzVyPUCuNVQzPzhizszN MX\TRW5ITVJ?
KINGS-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7qVnNnUUN3ME2wMlE1PzlizszN M{Dae3NCVkeHUh?=
NCI-H69 NW\YUJhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVGxRWZWUUN3ME2wMlE2OTRzIN88US=> M37DZnNCVkeHUh?=
CAS-1 M3TmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMUW0PFIh|ryP NFz1XmFUSU6JRWK=
D-263MG MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMU[wNFYh|ryP MX7TRW5ITVJ?
A253 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonmTWM2OD1yLkG2NVI5KM7:TR?= NYPEbpZ3W0GQR1XS
PF-382 NGLMfY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMU[3NFYh|ryP MlT5V2FPT0WU
CESS M4DuU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInOVGFKSzVyPUCuNVcxPiEQvF2= NF;VfZBUSU6JRWK=
MZ2-MEL Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMUe1OVkh|ryP NHLPXlZUSU6JRWK=
HEL NYTocmk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TJNmlEPTB;MD6xPFUyPyEQvF2= NESyTYZUSU6JRWK=
D-392MG NYTZNnUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi1TW1KSzVyPUCuNVkyOTVizszN MXnTRW5ITVJ?
SK-LMS-1 MlWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMUmzNFMh|ryP MnzHV2FPT0WU
GI-ME-N NXe1To9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrFUFh5UUN3ME2wMlE6OzB4IN88US=> NWXGT2wyW0GQR1XS
LB831-BLC NEnYNlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLXTWM2OD1yLkG5N|Qh|ryP M3zmT3NCVkeHUh?=
DU-4475 Mkf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTKTWM2OD1yLkG5OlU5KM7:TR?= M2XKTHNCVkeHUh?=
IST-SL1 M4PuRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3hTWM2OD1yLkKwNFk1KM7:TR?= MV7TRW5ITVJ?
GAK M4rKO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f6dWlEPTB;MD6yNFU{PCEQvF2= MlnvV2FPT0WU
EW-1 M1PmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TrN2lEPTB;MD6yNVA1PyEQvF2= M4\IeXNCVkeHUh?=
LAMA-84 MlPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HQRWlEPTB;MD6yNVg2OSEQvF2= MkS3V2FPT0WU
SK-UT-1 NH\0SZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITlOIJKSzVyPUCuNlIxPDlizszN MXrTRW5ITVJ?
VA-ES-BJ M1Tpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMkKyOVch|ryP Moe0V2FPT0WU
ACN MlfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe0cGZQUUN3ME2wMlIzPjN6IN88US=> MoizV2FPT0WU
SK-PN-DW MkfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMkOxPUDPxE1? M1rSNHNCVkeHUh?=
HD-MY-Z NHiwTVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfkZ49KSzVyPUCuNlM{ODNizszN NVjLOpdvW0GQR1XS
LB373-MEL-D NVT6d4pxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj5NJpsUUN3ME2wMlI1OTl6IN88US=> NVvjepg5W0GQR1XS
COLO-829 NYPrXlZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTadHlKSzVyPUCuNlQzPTdizszN NIfD[HpUSU6JRWK=
ES8 NWfubm5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfpS|dKSzVyPUCuNlQ4PjNizszN NV3CO2dxW0GQR1XS
RXF393 NV\SV2xOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml72TWM2OD1yLkK1NFE2KM7:TR?= NXrrboFrW0GQR1XS
TK10 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPDZodKSzVyPUCuNlU1OzVizszN NHHJWllUSU6JRWK=
LOUCY NUPJN|hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMkW0OVYh|ryP MmDSV2FPT0WU
MZ7-mel M4Swd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DCemlEPTB;MD6yOlM4PCEQvF2= MWLTRW5ITVJ?
CP67-MEL NEHObVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HpRWlEPTB;MD6yOlc{KM7:TR?= NWLGTnJXW0GQR1XS
C2BBe1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFyzVYdKSzVyPUCuNlc6ODdizszN NXz6SZVnW0GQR1XS
K052 NY[xO2hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4C4OWlEPTB;MD6yPFk6KM7:TR?= NXTnWpE2W0GQR1XS
MOLT-16 MlLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPXV3BVUUN3ME2wMlI6PTJ2IN88US=> M37YNnNCVkeHUh?=
KNS-81-FD MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnzWXBKSzVyPUCuN|A{OjNizszN MX;TRW5ITVJ?
CMK NIj3RZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXQTWM2OD1yLkOxNVIh|ryP NU\iUXMzW0GQR1XS
LAN-6 M2G2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1GyVWlEPTB;MD6zNVMh|ryP MYfTRW5ITVJ?
KLE MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7RTWM2OD1yLkOxN|A3KM7:TR?= MVXTRW5ITVJ?
NCCIT NX3lfW9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwM{G3PFMh|ryP MUPTRW5ITVJ?
HH NETuV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwM{K4PVch|ryP MY\TRW5ITVJ?
TE-8 NWjOOoFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwM{SyO|kh|ryP NYLURmV5W0GQR1XS
GDM-1 NXjXWIJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX3TWM2OD1yLkO1NVA1KM7:TR?= NYHnd2VEW0GQR1XS
NCI-H747 MnPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknRTWM2OD1yLkO3NVA{KM7:TR?= NEfzdYRUSU6JRWK=
NCI-H1092 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfYdINrUUN3ME2wMlM5QDR2IN88US=> NF\pPHBUSU6JRWK=
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NB17 NEnmSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS4WpJCUUN3ME2wMlQzQTdizszN MVXTRW5ITVJ?
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NCI-H1882 MnuyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwNUmwN|Yh|ryP MmnrV2FPT0WU
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NCI-H2126 MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwNkK2Olkh|ryP NWLMZmw{W0GQR1XS
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NCI-H1355 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL1eJh2UUN3ME2wMlY5PjF7IN88US=> NWDwS5NlW0GQR1XS
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COLO-684 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\lTWM2OD1yLkmwOlU5KM7:TR?= MVLTRW5ITVJ?
HCC2998 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG4TWM2OD1yLkmzPFU1KM7:TR?= M{nDNHNCVkeHUh?=
TE-10 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrwVWRKSzVyPUCuPVY1OyEQvF2= NEnNRYtUSU6JRWK=
SF126 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfSXZY{UUN3ME2wMlk5QTdzIN88US=> NXvmV|B{W0GQR1XS
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LU-65 Mki5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnvTWM2OD1zLkGyO|U{KM7:TR?= MUjTRW5ITVJ?
MFH-ino NEPy[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rFNmlEPTB;MT6xO|UxOSEQvF2= NFHtVIZUSU6JRWK=
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NCI-H719 NWfzfmc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPXTWM2OD1zLkK3OFEyKM7:TR?= MoTrV2FPT0WU
SW684 NXXHS4U3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jmeGlEPTB;MT6yPFY2QSEQvF2= MUjTRW5ITVJ?
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NCI-H128 M4r4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTFwM{W4NVQh|ryP NWfY[4pvW0GQR1XS
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DMS-114 MkDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r0TmlEPTB;MT60OFU{QSEQvF2= NGDDNFNUSU6JRWK=
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NCI-H2081 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFwNUWxPVYh|ryP MWnTRW5ITVJ?
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NCI-H2227 NUW4eWhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7PTWM2OD1zLk[xOVYyKM7:TR?= MoPzV2FPT0WU
D-502MG NHLRbJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\zTGlEPTB;MT62O|IyOSEQvF2= MV3TRW5ITVJ?
NCI-H2141 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwNkezNVch|ryP MXrTRW5ITVJ?
LS-411N NWTJVoxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnQPXhOUUN3ME2xMlY6QDB5IN88US=> M4e4VXNCVkeHUh?=
SU-DHL-1 NGPiPJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzSVXZkUUN3ME2xMlcyOjhzIN88US=> M4\xS3NCVkeHUh?=
BB30-HNC M3vLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rMd2lEPTB;MT63NlY5PSEQvF2= MUjTRW5ITVJ?
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JVM-3 M{nUd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXyR3FoUUN3ME2xMlk{QTB2IN88US=> M{\XTHNCVkeHUh?=
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EW-18 MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDUTWM2OD1{LkCyN|M4KM7:TR?= MWPTRW5ITVJ?
DJM-1 Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDHcWxKSzVyPUKuNFI2PTJizszN M1;2R3NCVkeHUh?=
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MC-CAR MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrhTWM2OD1{LkKyPVUh|ryP MnLKV2FPT0WU
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ECC12 NYjZ[HZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;wSm5OUUN3ME2yMlM4QTRizszN MY\TRW5ITVJ?
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MFM-223 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjzNFlJUUN3ME2yMlUxQDdzIN88US=> M{PoXHNCVkeHUh?=
SW982 NGfS[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7jfm0{UUN3ME2yMlUyPDhizszN M3\LWXNCVkeHUh?=
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ES4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLVTWM2OD1|LkC2NVEyKM7:TR?= MWHTRW5ITVJ?
SCC-3 NX\Jfm1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV71bmNCUUN3ME2zMlExQDR6IN88US=> NWnZOZZwW0GQR1XS
RH-1 NWfUdmdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvweIFKSzVyPUOuN|g4PDhizszN NHvCTmpUSU6JRWK=
NCI-H748 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17DO2lEPTB;Mz60OFI3PiEQvF2= NIS0NodUSU6JRWK=
HCC2218 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vYT2lEPTB;Mz60Olk{PyEQvF2= MmnlV2FPT0WU
MEG-01 Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTjTWM2OD1|LkW5Olgh|ryP Mn3mV2FPT0WU
NB12 NX3hTVVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULTe4VJUUN3ME2zMlU6QDh6IN88US=> NH\VNpZUSU6JRWK=
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KMS-12-PE M{nI[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXEZWd3UUN3ME2zMlY4PzJ|IN88US=> NUXob2JDW0GQR1XS
SKM-1 M4jCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jiU2lEPTB;Mz63NVM4PiEQvF2= MWDTRW5ITVJ?
COLO-320-HSR NIr5RXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTNwN{W2N|Qh|ryP MmfCV2FPT0WU
NKM-1 MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLRcpZKSzVyPUOuO|c{PzhizszN MonrV2FPT0WU
TE-6 NFzrb2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37MdGlEPTB;Mz65OFU3OSEQvF2= NHzJbVlUSU6JRWK=
D-336MG NIXFXJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWize|lzUUN3ME20MlAyOTZ4IN88US=> MmX3V2FPT0WU
NCI-H1650 MlXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2KxRmlEPTB;ND6xOVc6PyEQvF2= NVP6NlJ{W0GQR1XS
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LB647-SCLC NETiem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\Lb|Z[UUN3ME20MlU3OzB6IN88US=> MXrTRW5ITVJ?
HAL-01 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXmS2xKSzVyPUSuOVcxOzRizszN NEKxS5pUSU6JRWK=
LP-1 NXG2eZQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\DPXNKSzVyPUSuO|I{PzFizszN MWnTRW5ITVJ?
BC-1 NUnOTlB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWOzW416UUN3ME21MlAxPDR5IN88US=> Mmr2V2FPT0WU
EB-3 NET0eoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13meWlEPTB;NT6wN|A1OSEQvF2= M3fkR3NCVkeHUh?=
GT3TKB NF\S[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTVwMUe2OlIh|ryP M{TGc3NCVkeHUh?=
NCI-H209 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfWcYlUUUN3ME21MlE6OzV{IN88US=> MlHoV2FPT0WU
BT-474 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TY[mlEPTB;NT6yN|ExOiEQvF2= NIP1NGNUSU6JRWK=
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SIMA NXrKZpN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPkdlFKSzVyPUWuN|A4PjVizszN NUT6Xmh[W0GQR1XS
RL Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUL0bYlPUUN3ME21MlM4PTRzIN88US=> NGXSc2NUSU6JRWK=
GCIY MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTVwNEeyN|Yh|ryP M{jhO3NCVkeHUh?=
Calu-6 M1TUO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTVwNkKyJO69VQ>? M1vO[nNCVkeHUh?=
ALL-PO NFnTdWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjCTWM2OD13Lk[zO|k2KM7:TR?= NFPNU5VUSU6JRWK=
ARH-77 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu3ZYdpUUN3ME21MlY4ODh5IN88US=> M{\qVXNCVkeHUh?=
A4-Fuk NEnFXXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfXT3ZKSzVyPU[uNFgyOThizszN MnTuV2FPT0WU
NCI-H1581 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;NTWM2OD14LkKzPFQ6KM7:TR?= NVzaZnVsW0GQR1XS
HUTU-80 M2DrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDlclJKSzVyPU[uN|Y5QTdizszN MorSV2FPT0WU
TGW M2nqbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTZwNEW1PVMh|ryP M4nYcXNCVkeHUh?=
SK-N-FI MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzBbmRKSzVyPU[uOFU5PTRizszN NYXaSmFtW0GQR1XS
U-266 MkjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;IcGlEPTB;Nj61NVkzPiEQvF2= MVrTRW5ITVJ?
EM-2 NFjrTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDFOJV2UUN3ME22MlY4ODl7IN88US=> MnHxV2FPT0WU
NMC-G1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzxSnR5UUN3ME22MlcyQDl3IN88US=> MkPFV2FPT0WU
KASUMI-1 NEDQXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLKTWM2OD14Lki0O|g4KM7:TR?= MWHTRW5ITVJ?
NALM-6 NISyZVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\KO4h6UUN3ME22Mlg3PzV2IN88US=> MlHMV2FPT0WU
OCI-AML2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr6U49VUUN3ME23MlAxOzJ4IN88US=> NETJXFJUSU6JRWK=
SHP-77 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDoTWM2OD15LkKyOFMh|ryP NFnaPW5USU6JRWK=
NOMO-1 Moi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv3fI9KSzVyPUeuNlQzPTRizszN M3G0[nNCVkeHUh?=
SK-N-DZ MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\zdmlEPTB;Nz63NVA5QSEQvF2= NWHMeHNZW0GQR1XS
LB1047-RCC NHfxWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTWOYFGUUN3ME23MlczOjNzIN88US=> NYLRfZpMW0GQR1XS
MZ1-PC NIXZeJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTdwOE[1OVgh|ryP MVHTRW5ITVJ?
NB10 MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\EZYREUUN3ME23Mlk6PTV4IN88US=> M175SHNCVkeHUh?=
RL95-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPMTWM2OD16LkGwPFQzKM7:TR?= NHvLWo1USU6JRWK=
OMC-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRThwNUKxPVEh|ryP MnznV2FPT0WU
D-283MED MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C3ZWlEPTB;OD65NVcyQSEQvF2= M{H5UHNCVkeHUh?=
MC116 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy4R5RiUUN3ME24Mlk4QTRizszN NHjyfWxUSU6JRWK=
SJSA-1 MlvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P3d2lEPTB;OT6wPVA6OSEQvF2= M{TxVHNCVkeHUh?=
JiyoyeP-2003 NGDNXXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLWfINKSzVyPUmuNlk{OTdizszN MU\TRW5ITVJ?
IST-MEL1 M2TVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrp[IRIUUN3ME25Mlc1OTl6IN88US=> NVTDc5VsW0GQR1XS
CTV-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW2S3ZKSzVyPUGwMlA6PzlizszN NEnlbI9USU6JRWK=
NH-12 M2nYcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXQTWM2OD1zMD6yOFM{KM7:TR?= NFXHWoJUSU6JRWK=
CA46 MnSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe5S|hKSzVyPUGwMlM3OSEQvF2= MlO2V2FPT0WU
NCI-SNU-1 M3PtSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX3N4tMUUN3ME2xNE41QTZ7IN88US=> NHH1PYZUSU6JRWK=
SCLC-21H MlThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPaNWpUUUN3ME2xNE43PTl4IN88US=> NI\1T2tUSU6JRWK=
EC-GI-10 M{\FdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfBT2o1UUN3ME2xNE44ODNzIN88US=> M3zKSXNCVkeHUh?=
SR NH7WbIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf3XWQzUUN3ME2xNU4xOTh3IN88US=> NWH4WFRqW0GQR1XS
NCI-H1648 NGG3RXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrDTWM2OD1zMT6wPVY2KM7:TR?= M2rpUXNCVkeHUh?=
TGBC1TKB NILl[2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjaTWM2OD1zMT60NVAzKM7:TR?= M{nafnNCVkeHUh?=
EW-11 M4TuTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHWclhKSzVyPUGxMlUyQDZizszN MmDHV2FPT0WU
SK-MM-2 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFzLkiwOlEh|ryP MYDTRW5ITVJ?
NCI-H524 M3jz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTFzLkm4NlIh|ryP M2HRNnNCVkeHUh?=
NOS-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF{LkCzOFUh|ryP NF34XXdUSU6JRWK=
AM-38 M2LC[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXztbHF6UUN3ME2xNk42PjN|IN88US=> M1ztUXNCVkeHUh?=
A498 NXXze5JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OxRmlEPTB;MUKuO|A3QSEQvF2= MUDTRW5ITVJ?
KARPAS-422 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTF{Lke0PVYh|ryP M4fiZnNCVkeHUh?=
LU-139 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Ox[mlEPTB;MUKuPVAzPiEQvF2= MXzTRW5ITVJ?
COR-L88 M1nuVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LOeWlEPTB;MUKuPVM5OiEQvF2= NIfWcWlUSU6JRWK=
K5 M1LObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvLZoZvUUN3ME2xNk46PDZ{IN88US=> NUPXc|N2W0GQR1XS
NB13 MlvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorsTWM2OD1zMj65O|g{KM7:TR?= NHPLZVJUSU6JRWK=
MRK-nu-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nOe2lEPTB;MUOuNVk2KM7:TR?= NVLIbFBRW0GQR1XS
MHH-NB-11 NVHuenRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTF|LkK5NFIh|ryP NF3GbXlUSU6JRWK=
KU812 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XaeWlEPTB;MUOuOlEzPCEQvF2= NWr0VmtwW0GQR1XS
TE-12 MoTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF|Lk[5PVQh|ryP NU\ufI1XW0GQR1XS
NCI-N87 MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvo[I5jUUN3ME2xN{44OzZizszN MXzTRW5ITVJ?
EB2 NH[xRXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TpNGlEPTB;MUOuPFUxPSEQvF2= MnSyV2FPT0WU
DB NUDsfldDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTF|Lkm4PFUh|ryP NWHCc3lxW0GQR1XS
697 NVTCR4htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfvXGs1UUN3ME2xOE41PTFzIN88US=> MlrNV2FPT0WU
MSTO-211H MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvnTWM2OD1zND63OFQ5KM7:TR?= M4TQZnNCVkeHUh?=
JVM-2 Mnj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;wTWM2OD1zND63O|M2KM7:TR?= M4LOR3NCVkeHUh?=
COLO-824 NUjCcohNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfuTWM2OD1zND63PVk1KM7:TR?= M{XtUXNCVkeHUh?=
BC-3 NX\WSIFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXacGNOUUN3ME2xOU4{QThizszN NXn5SHlJW0GQR1XS
BOKU NV3KZpBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTF3Lkm2NFgh|ryP NFn6RopUSU6JRWK=
GOTO NYPHdW1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXOTWM2OD1zNj65OlE4KM7:TR?= M{\KTHNCVkeHUh?=
HCC2157 NIrIUndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M16xdmlEPTB;MUeuOFc2PSEQvF2= M3\IVXNCVkeHUh?=
LS-1034 NGXDXmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF5Lk[4NVgh|ryP MXLTRW5ITVJ?
CAL-148 MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3GzS2lEPTB;MUeuPVc6PiEQvF2= NF7FfZdUSU6JRWK=
MOLT-4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PFOGlEPTB;MUiuPFIxQCEQvF2= M2S1cXNCVkeHUh?=
Daudi MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLzTWM2OD1zOD65NlMyKM7:TR?= M4jVN3NCVkeHUh?=
J-RT3-T3-5 NY[xeFVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfFTWM2OD1zOT60NFY3KM7:TR?= M{fyW3NCVkeHUh?=
KMOE-2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4flXWlEPTB;MUmuOlQ5OiEQvF2= MXPTRW5ITVJ?
HL-60 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrrR5JKSzVyPUKwMlE6PjVizszN MnfhV2FPT0WU
P31-FUJ NILwR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fOdWlEPTB;MkCuOFc2OyEQvF2= NGO2UJBUSU6JRWK=
IM-9 NIK1cVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;2[VlVUUN3ME2yNE43OjJ2IN88US=> Ml\MV2FPT0WU
HDLM-2 NIfQd4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTLTWM2OD1{MD64PFIyKM7:TR?= M3TQOnNCVkeHUh?=
NCI-H1304 M2Tt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nYWmlEPTB;MkGuNFMyOSEQvF2= M2nER3NCVkeHUh?=
NCI-H345 NVXwZ3NQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX30cYpUUUN3ME2yNU4xPjR|IN88US=> MVjTRW5ITVJ?
RPMI-6666 MmTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;CTWM2OD1{MT6zOlAzKM7:TR?= MonHV2FPT0WU
GR-ST NIfVbmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfrTWM2OD1{MT60NVch|ryP NFHRTWRUSU6JRWK=
CHP-126 NIS4T3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jBb2lEPTB;MkGuOlE5OSEQvF2= M3O4O3NCVkeHUh?=
EHEB NIrOT4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPhNZJUUUN3ME2yNU43PzNzIN88US=> MYLTRW5ITVJ?
CPC-N MmGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jWWGlEPTB;MkSuNFIxOSEQvF2= NFvnUphUSU6JRWK=
NB1 M2H5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[0TWM2OD1{ND62PVM6KM7:TR?= NH;h[|dUSU6JRWK=
LS-123 NILIe3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXKTWM2OD1{ND65NFEzKM7:TR?= Mm\mV2FPT0WU
ST486 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjNR|NKSzVyPUK1MlEyOTNizszN M3PGVHNCVkeHUh?=
NCI-H1963 MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\1bIwxUUN3ME2yOk4xPjJ|IN88US=> NFvKOFVUSU6JRWK=
U-87-MG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnPS5RFUUN3ME2yOk44PjR2IN88US=> MmHvV2FPT0WU
COR-L279 NWrRPYV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jGdWlEPTB;Mk[uO|kzOiEQvF2= M3;JRXNCVkeHUh?=
LU-165 NFL1[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3K1XmlEPTB;MkiuNFg3OSEQvF2= NGn1[XVUSU6JRWK=
COLO-800 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHxPGpKSzVyPUK4MlI6PTZizszN Mk\mV2FPT0WU
ETK-1 NXzuTVdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ6LkO0OFYh|ryP MnvkV2FPT0WU
LNCaP-Clone-FGC M4\Qd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LrdWlEPTB;MkmuPVI5OSEQvF2= MWjTRW5ITVJ?
SIG-M5 NHy5W2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNyLke5OVIh|ryP MUTTRW5ITVJ?
NB6 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;mTWM2OD1|MD65OVA{KM7:TR?= MWHTRW5ITVJ?
NCI-H2107 NYDUbJQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjB[IlKSzVyPUOxMlI{OzhizszN MVfTRW5ITVJ?
SNU-C1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfsTJZQUUN3ME2zNU4{OTJ4IN88US=> NWnE[YNGW0GQR1XS
JAR MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIq5d2tKSzVyPUOxMlM4QTlizszN NWDHR2s4W0GQR1XS
L-363 NUG5NoVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\jUmlEPTB;M{KuNlE1PCEQvF2= MWPTRW5ITVJ?
EW-24 NGToTHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;F[YtKSzVyPUOyMlM1PzRizszN M4e5cHNCVkeHUh?=
NB69 NFHNOpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfGNJc{UUN3ME2zN{43PDV2IN88US=> MV;TRW5ITVJ?
EW-13 NXX6ZXAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPzRo1GUUN3ME2zN{45QTZ7IN88US=> NXfRfG1XW0GQR1XS
Ramos-2G6-4C10 NIr6WXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn1W|FKSzVyPUO0MlI6QTNizszN Mon2V2FPT0WU
TE-11 M3rhdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLCUGhKSzVyPUO0MlQ5OjJizszN M3ftSnNCVkeHUh?=
L-428 NUH1SWE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN2Lke1N|Yh|ryP MofhV2FPT0WU
KP-N-YN M3;XVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HpXGlEPTB;M{SuPVA2PyEQvF2= NGPxT21USU6JRWK=
CGTH-W-1 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN4LkmwOFgh|ryP MW\TRW5ITVJ?
K-562 NEewSIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXRNoFKSzVyPUO3MlA5PjRizszN MV7TRW5ITVJ?
NCI-H1299 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTN6LkG2NFMh|ryP NVfIO5NxW0GQR1XS
RCC10RGB MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTN6LkKwPFMh|ryP NVv3OoY{W0GQR1XS
NCI-SNU-16 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHnTGw2UUN3ME2zPE42PjV|IN88US=> NFOwNpZUSU6JRWK=
LC-2-ad NFy0WY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33JcmlEPTB;M{muOFM{PyEQvF2= NVPjUVFDW0GQR1XS
MHH-PREB-1 NVf6eG9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTN7LkezPFgh|ryP M3XJW3NCVkeHUh?=
NCI-H64 MmLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHtZ21KSzVyPUSwMlA6PDhizszN Mn\KV2FPT0WU
LB996-RCC MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjlNohKSzVyPUSwMlg4OTZizszN MnH2V2FPT0WU
DEL NFK3WIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTPNJlzUUN3ME20NU41PDB3IN88US=> M37xenNCVkeHUh?=
MLMA NUDkWI1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfafGtKSzVyPUSxMlc2QTVizszN MXXTRW5ITVJ?
SBC-1 M4fkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR{LkG4NFYh|ryP MWDTRW5ITVJ?
MPP-89 M3jrTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M365[2lEPTB;NEKuOVg4PSEQvF2= Ml6zV2FPT0WU
MV-4-11 MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqwTWM2OD12Mj65NFY4KM7:TR?= M4DiR3NCVkeHUh?=
EoL-1- NV7ZWZJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnj5TWM2OD12ND6xOVY5KM7:TR?= MWLTRW5ITVJ?
CW-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHHPZdKSzVyPUS0Mlg{PDJizszN NI\INXBUSU6JRWK=
HT MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPjVJp1UUN3ME20OU44ODB5IN88US=> MX7TRW5ITVJ?
SW954 Ml3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUOxSFhPUUN3ME20O{41OTJ6IN88US=> NVviU3NZW0GQR1XS
A3-KAW NX;iSW41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W0OGlEPTB;NEmuPFA3OSEQvF2= MmTyV2FPT0WU
TC-YIK MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3tcFRKSzVyPUWwMlA{PjNizszN MmD3V2FPT0WU
SW962 MoTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrTPGhQUUN3ME21OE45OzV5IN88US=> MlvTV2FPT0WU
KP-N-RT-BM-1 NFLNO|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jHUWlEPTB;NU[uOlY{QCEQvF2= NHnzcVNUSU6JRWK=
NCI-H1395 MnnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTV6LkixO|Ih|ryP NHrTU|NUSU6JRWK=
RPMI-8402 NUTEN3BKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTV6Lkm1NlYh|ryP MXTTRW5ITVJ?
SCH MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PITGlEPTB;NkCuPVY{QCEQvF2= Mm[wV2FPT0WU
NCI-H2196 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj2TWM2OD14MT6yN|Eh|ryP M3XzWXNCVkeHUh?=
LOXIMVI MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jTVWlEPTB;NkGuPFI3PiEQvF2= NWTaRYpqW0GQR1XS
TGBC24TKB NWCwfFU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3PT4tuUUN3ME22Nk4yPDlzIN88US=> NH36S5VUSU6JRWK=
SK-MEL-2 NGq1[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjIV2FKSzVyPU[zMlk5QTJizszN MUTTRW5ITVJ?
U-698-M M3jtR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjPcmdKSzVyPU[4MlU3QDdizszN NYHuZ3p4W0GQR1XS
NCI-H1522 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorXTWM2OD14OT6wNFQ4KM7:TR?= M3LoZ3NCVkeHUh?=
UACC-812 MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF65OlVKSzVyPU[5MlUzODlizszN NH\ofHdUSU6JRWK=
MHH-CALL-2 NYC2UWlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTdyLkC2JO69VQ>? MlP0V2FPT0WU
NB5 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXJUIdKSzVyPUewMlM1PjhizszN M1HCZnNCVkeHUh?=
KARPAS-299 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHftT5NKSzVyPUewMlQ1PDdizszN NYLqNGtTW0GQR1XS
NCI-H1694 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7qTWM2OD15MT6wN|Ih|ryP MUPTRW5ITVJ?
NCI-H82 M333N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\nTWM2OD15MT65OVA4KM7:TR?= M1HCZnNCVkeHUh?=
SCC-15 M4PrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\oeGFwUUN3ME23Nk4{PCEQvF2= NWXqUmtnW0GQR1XS
NCI-H1436 NGW2TotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTybHl6UUN3ME23Nk44PDV4IN88US=> NVfZZlRFW0GQR1XS
ATN-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HrUmlEPTB;N{SuOVA2KM7:TR?= NIPhW3JUSU6JRWK=
RPMI-8866 NVzTelA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTj[VV1UUN3ME23OE44PTB7IN88US=> NEHLOYJUSU6JRWK=
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... Click to View More Cell Line Experimental Data

In vivo試験 Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Measurement of inhibitory activities of MG-132 against 20S proteasome The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.

細胞アッセイ:

[3]

細胞株 KIM-2, HC11, and ES
濃度 Dissolved in DMSO, final concentrations ~25 μM
反応時間 24, and 48 hours
実験の流れ

Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.

動物実験:

[7]

動物モデル Male mdx (C57BL/10ScSn DMD mdx) mice
製剤 Dissolved in DMSO, and diluted in PBS
投薬量 ~10 μg/kg/day
投与方法 Injection

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MG-132 SDF
分子量 475.62
化学式

C26H41N3O5

CAS No. 133407-82-6
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 95 mg/mL (199.73 mM)
エタノール 95 mg/mL (199.73 mM)
<1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate

文献中の引用 (45)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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