MG-132 化学構造
分子量: 475.62

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Quality Control & MSDS

製品説明

  • Compare Proteasome Inhibitors
    Proteasome製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 MG-132は、100nMのIC50によるプロテアソームの強力な阻害剤です。
ターゲット

Proteasome

IC50

100 nM [1]

In vitro試験 MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
LPS-stimulated RAW264.7 cells M3LlUGZ2dmO2aX;uJGF{e2G7 NVPhSnhQOjVizszN MU\EUXNQ NEfHVYxKdmirYnn0d{BvcXS{aXOgc5hq\GVicILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOC5zIN88US=> MWeyOFY6PzR7Nh?=
HL-60 MnfGR5l1d3SxeHnjJGF{e2G7 MV[0NEDPxE1? MnrYOFghcA>? M1;kb2ROW09? MlLkTWM2ODxzMDFOwG0> MVyyOFY6PzR7Nh?=
SMMC-7721 M2GzWWN6fG:2b4jpZ{BCe3OjeR?= MoTrOFAh|ryP NXXCXZZ2PDhiaB?= M1rD[2ROW09? NELMUVdKSzVyPUeuNUDPxE1? MUCyOFY6PzR7Nh?=
A-549 MnH3R5l1d3SxeHnjJGF{e2G7 MXG0NEDPxE1? NUXabm4zPDhiaB?= NXPScFVKTE2VTx?= M2[3TWlEPTB:MUCg{txO NIH1Z4ozPDZ7N{S5Oi=>
MCF-7 M1TRUGN6fG:2b4jpZ{BCe3OjeR?= MVe0NEDPxE1? NYXRS2E6PDhiaB?= M2D1emROW09? M1ryRmlEPTB;Nz6zJO69VQ>? NX3he2syOjR4OUe0PVY>
SW-480 M1XzT2N6fG:2b4jpZ{BCe3OjeR?= NWq2TpE{PDBizszN NF2wTVQ1QCCq MlnUSG1UVw>? Mk[xTWM2OD12IN88US=> MUKyOFY6PzR7Nh?=
NCI-H929 MkHBR5l1d3SxeHnjJGF{e2G7 M3zXUlEh|ryP MUW3NkBp MXPEUXNQ NHnNZZlKSzVyPUCuNVch|ryP Ml\HNlQ3OjVyOEi=
293T NXvG[oplS3m2b4TvfIlkKEG|c3H5 MWCxNEDPxE1? MkXlO|IhcA>? NEGxfm5FVVOR NUPi[25RUUN3MEyyJO69VQ>? MVWyOFYzPTB6OB?=
293T Mn3GSpVv[3Srb36gRZN{[Xl? MXSxNEDPxE1? M33HWVI1KGh? MX3EUXNQ MnrvUY9l\XKjdHXsfUBqdmS3Y3XzJIhm[XRvc3jvZ4shKA>? MY[yOFYzPTB6OB?=
HeLa MWrLbY5ie2ViQYPzZZk> MWOxNEDPxE1? M1jqOVEhcA>? MoXRSG1UVw>? NEH2bJhKdmS3Y3XzJHBCWlBiY3zlZZZi\2ViYomgbY5pcWKrdHnu[{Bxem:|ZXHzc41mKGGldHn2bZR6 M1\vNFI1OzJzOEOz
MDA-MB-231 M3uxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXUNUDPxE1? M{n4VFczKGh? NV3DXlFZTE2VTx?= NEXoe|RKSzVyPUCuNVgh|ryP NX\Wbm01OjRzNUOyNFY>
MCF-7 NYLJRm8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHu5W48yKM7:TR?= MXG3NkBp Mm\YSG1UVw>? MWPJR|UxRTBwMUOg{txO NY\1TZBXOjRzNUOyNFY>
MCF10A NH7wXHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX:xJO69VQ>? NGLPPFc4OiCq NEH5OJpFVVOR M{nDdWlEPTB;MD6yPUDPxE1? MofiNlQyPTN{ME[=
HEK-293 MoK4T4lv[XOnIFHzd4F6 MUCyJIFv\CB{MDFOwG0> NVfiRYJ5OiCq NWTtNY44TE2VTx?= M1nEPGlvcGmkaYTzJGNpXC2OIHHjeIl3cXS7IIfpeIghUUN3MDDv[kA6KG6PIB?= M4j4NFI{PTRyN{mw
Calu6 MoLUSpVv[3Srb36gRZN{[Xl? MmTXNVAh|ryP MWGxPEBp NVS5S5U{TE2VTx?= MVvTbYdvcW[rY3HueIx6KGGlY4XteYxifGW|IH\yZZRigGmwIIDy[YN2enOxch?= M1TaflI{PTB4NEi2
IFN-gamma-induced RAW264.7 NULPeI9bTnWwY4Tpc44hSXO|YYm= MojiSG1UVw>? M17yPGlvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjB5NzFOwG0> MUiyNlI4PzJ5Nx?=
IPC227F NXn1NlJJS3m2b4TvfIlkKEG|c3H5 MVGxJO69VQ>? MWG0PEBp NX;5c|dCTE2VTx?= MkTnTWM2OD1yLkC3O{DPxE1? NFTFSYszOTl{NEWyPC=>
Hepa-1c1c7 NX7teG5zTnWwY4Tpc44hSXO|YYm= MYeyOUDPxE1? MXW2JIg> MWnEUXNQ NH[yT5JKdmO{ZXHz[ZMhVnKoMjDwdo91\WmwIHzleoVt MUiyNFM6OjV2NB?=
COS-7 MlrsR5l1d3SxeHnjJGF{e2G7 MlvZNVAh|ryP NFryfG5FVVOR M{HXfGlEPTB:MUCg{txO M3nnXlE5ODh6MEm3
HuH-7 M4fVc2N6fG:2b4jpZ{BCe3OjeR?= NXLNOVB1OTBizszN MXHEUXNQ MoK4TWM2ODxzMDFOwG0> MkHyNVgxQDhyOUe=
OCI-Ly3 M4[xNWZ2dmO2aX;uJGF{e2G7 NI\4XWMyOCEQvF5CpC=> NV\SVHE2PCCq NITEZWhFVVOR MkLlTY5lfWOnczDoeY1idiCLa3HwdIFD[WyyaHGgd5Ri[mmuaYrheIlwdiC5aYToJGVEPTBib3[gNUDPxE1? M4XzNVE5ODJ2MUGz
A2780 cDDP Ml7XRZBweHSxc3nzJGF{e2G7 M1;sU|I1KGh? MVvEUXNQ NVrCZXVuUW6mdXPld{BieG:ydH;zbZMh[nliaX7obYJqfGmwZzDQWGVPKGSnZ4Lh[IF1cW:w MlfVNVc3QDRyMUi=
LPS-stimulated RAW264.7 cells NEjuV5BHfW6ldHnvckBCe3OjeR?= M2fGXWROW09? NUjzfZp6UW6qaXLpeJMhVkZva3HwdIFDKESQQTDibY5lcW6p NIPGfWsyPzRyN{K3Oy=>
PC12 MWrGeY5kfGmxbjDBd5NigQ>? MoKxNVAxKM7:TdMg NHfRWmEzPCCq NVjEZVJzTE2VTx?= NHG5cJFKdmirYnn0d{A3NU:KRFGtJIFv\CCKMl:yMYlv\HWlZXSgZ5l1d3SxeHnjbZR6 NYOyeVV{OTdzNUi0OVQ>
PC3 M4\vOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M321TlIxKM7:TR?= NFXUVYM1QCCq NXfxbZRnTE2VTx?= M3nVSGlEPTB;MD62JO69VQ>? MUexOlY5PjV|Nx?=
LP-1 NU[1[2E4SXCxcITvd4l{KEG|c3H5 MY[zNFAhdk1? M4DObFI1KGh? MlzVSG1UVw>? MXPJcoR2[2W|IHHwc5B1d3OrczDifUBqdmO{ZXHzbY5oKGOuZXH2[YQhWEGUUDDs[ZZmdCCjbnSgdoVlfWOrbnegUYNtNTFicILveIVqdiCuZY\lcC=> M1\O[|E2QTV6NUi5
ES6 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojlTWM2OD1yLkCxN|A3KM7:TR?= M{XPWHNCVkeHUh?=
A101D MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XsfGlEPTB;MD6wN|I4QSEQvF2= M1SwfnNCVkeHUh?=
OCUB-M M3rR[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHGTWM2OD1yLkCzO|M4KM7:TR?= Mk\WV2FPT0WU
LB2518-MEL MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT1eGw4UUN3ME2wMlA{PzZizszN MXrTRW5ITVJ?
SH-4 MnXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfrUnVKSzVyPUCuNFQ{OSEQvF2= M3rpUnNCVkeHUh?=
KNS-42 NFSydXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorDTWM2OD1yLkC0OFQyKM7:TR?= NWDDS446W0GQR1XS
DSH1 NF3INHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfybXJIUUN3ME2wMlA2Ojh7IN88US=> MW\TRW5ITVJ?
NTERA-S-cl-D1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHXclF3UUN3ME2wMlA2Pzd{IN88US=> M1rUO3NCVkeHUh?=
D-542MG NU\0RZZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XHbmlEPTB;MD6wOVk2PyEQvF2= MmDMV2FPT0WU
KS-1 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPYTWM2OD1yLkC2OFU5KM7:TR?= MmP1V2FPT0WU
BL-41 M2\FOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofnTWM2OD1yLkC2PVQ4KM7:TR?= MX;TRW5ITVJ?
LXF-289 NIPFPG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofuTWM2OD1yLkC3NFY3KM7:TR?= NXrtRW9OW0GQR1XS
D-247MG M{S2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq3b45LUUN3ME2wMlA4OjB7IN88US=> M1LaWXNCVkeHUh?=
MMAC-SF NU\VO3VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\kZ2lEPTB;MD6wO|I3QCEQvF2= NF;Jcm5USU6JRWK=
CP66-MEL MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEe1JO69VQ>? NWGxcZN4W0GQR1XS
LB771-HNC NGrORpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1KxPWlEPTB;MD6wPFA{PiEQvF2= M3zhbnNCVkeHUh?=
no-10 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHoTWM2OD1yLkC4PVA6KM7:TR?= NIXFPIZUSU6JRWK=
A388 M{fCemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3FUXZMUUN3ME2wMlA6ODZ3IN88US=> MnnMV2FPT0WU
OPM-2 NXLSUlRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoD5TWM2OD1yLkGwOFc1KM7:TR?= MXLTRW5ITVJ?
OVCAR-4 M4XsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zKZ2lEPTB;MD6xNFk{QCEQvF2= MXjTRW5ITVJ?
HOP-62 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHexcXNKSzVyPUCuNVA6PDlizszN M3LjdXNCVkeHUh?=
ML-2 NVP4dY5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnpbIxKSzVyPUCuNVE5ODZizszN NHe0ZVBUSU6JRWK=
UACC-257 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGwTWM2OD1yLkGxPVI4KM7:TR?= NI\HNVlUSU6JRWK=
NEC8 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLKS5dzUUN3ME2wMlEyQTl3IN88US=> MlHHV2FPT0WU
ONS-76 NYTkXWJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMUK5N|Uh|ryP NYfn[nJLW0GQR1XS
KE-37 NXLPTY1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHDSoRKSzVyPUCuNVMzPzhizszN NUf5PZpqW0GQR1XS
HT-144 M4XhS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnwcGdKSzVyPUCuNVM5QTVizszN MYHTRW5ITVJ?
LB2241-RCC NWPCTI97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml6yTWM2OD1yLkG0NlQ4KM7:TR?= MWDTRW5ITVJ?
TE-5 NY[0WGVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMUSyO|gh|ryP M1PXZXNCVkeHUh?=
KINGS-1 M37nPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmzeoJKSzVyPUCuNVQ4QSEQvF2= MY\TRW5ITVJ?
NCI-H69 NITYZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HJOGlEPTB;MD6xOVE1OSEQvF2= M1;OS3NCVkeHUh?=
CAS-1 NF\6T2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj1dGt1UUN3ME2wMlE2PDh{IN88US=> MkX1V2FPT0WU
D-263MG M{TuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLM[21KSzVyPUCuNVYxODZizszN M3TpTXNCVkeHUh?=
A253 NWfFcoV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrkTWM2OD1yLkG2NVI5KM7:TR?= MY\TRW5ITVJ?
PF-382 NV7zXIZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\EdlNiUUN3ME2wMlE3PzB4IN88US=> MlPrV2FPT0WU
CESS MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTmOHZKSzVyPUCuNVcxPiEQvF2= NITQ[HlUSU6JRWK=
MZ2-MEL NILHN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT5TWM2OD1yLkG3OVU6KM7:TR?= MkC4V2FPT0WU
HEL MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK1TXVKSzVyPUCuNVg2OTdizszN NGfOcXlUSU6JRWK=
D-392MG NHu5d4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OxWmlEPTB;MD6xPVEyPSEQvF2= NULhSFhrW0GQR1XS
SK-LMS-1 NUnuVZRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f4dmlEPTB;MD6xPVMxOyEQvF2= M3z1ZnNCVkeHUh?=
GI-ME-N NVHzVpB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS0TWM2OD1yLkG5N|A3KM7:TR?= M1\YWnNCVkeHUh?=
LB831-BLC M{DQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;PSoRYUUN3ME2wMlE6OzRizszN NUGzOFE3W0GQR1XS
DU-4475 NGXRZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXJTWM2OD1yLkG5OlU5KM7:TR?= MoDKV2FPT0WU
IST-SL1 NXXn[lU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMkCwPVQh|ryP MXLTRW5ITVJ?
GAK MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMkC1N|Qh|ryP MYjTRW5ITVJ?
EW-1 M{HwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\ie4tGUUN3ME2wMlIyODR5IN88US=> MWDTRW5ITVJ?
LAMA-84 NUPlWJUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMkG4OVEh|ryP M{\NcHNCVkeHUh?=
SK-UT-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;YbINuUUN3ME2wMlIzODR7IN88US=> NXL3TJU1W0GQR1XS
VA-ES-BJ Mn;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWm0WGF7UUN3ME2wMlIzOjV5IN88US=> NXP3UWNRW0GQR1XS
ACN MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMkK2N|gh|ryP MlPDV2FPT0WU
SK-PN-DW MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMkOxPUDPxE1? NHjUU|dUSU6JRWK=
HD-MY-Z M4XDOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMkOzNFMh|ryP NIX2VVlUSU6JRWK=
LB373-MEL-D NH3i[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DzeGlEPTB;MD6yOFE6QCEQvF2= NGLle4NUSU6JRWK=
COLO-829 Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17oN2lEPTB;MD6yOFI2PyEQvF2= MmPDV2FPT0WU
ES8 NXHCRZlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMkS3OlMh|ryP NUD0ZmhHW0GQR1XS
RXF393 NXvITJhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[1TWM2OD1yLkK1NFE2KM7:TR?= NVTaTGsxW0GQR1XS
TK10 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3JN2NKSzVyPUCuNlU1OzVizszN NHnaV29USU6JRWK=
LOUCY NHHSZ4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMkW0OVYh|ryP NVTv[41MW0GQR1XS
MZ7-mel M4q2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMk[zO|Qh|ryP M2XHbXNCVkeHUh?=
CP67-MEL M{fVTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPaUFhKSzVyPUCuNlY4OyEQvF2= NHq1S|lUSU6JRWK=
C2BBe1 NUPvfHk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTvTWM2OD1yLkK3PVA4KM7:TR?= Ml\XV2FPT0WU
K052 NH\WVXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIT1[FZKSzVyPUCuNlg6QSEQvF2= MXnTRW5ITVJ?
MOLT-16 Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HuTWlEPTB;MD6yPVUzPCEQvF2= M4Lie3NCVkeHUh?=
KNS-81-FD MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwM{CzNlMh|ryP NELO[5VUSU6JRWK=
CMK MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfFdY9KSzVyPUCuN|EyOiEQvF2= MVnTRW5ITVJ?
LAN-6 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwM{GzJO69VQ>? M1y1SHNCVkeHUh?=
KLE Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEO5TGhKSzVyPUCuN|E{ODZizszN MmW1V2FPT0WU
NCCIT MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHKSVBNUUN3ME2wMlMyPzh|IN88US=> Mn34V2FPT0WU
HH M1PIOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvOTWM2OD1yLkOyPFk4KM7:TR?= MVvTRW5ITVJ?
TE-8 MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHVS2d1UUN3ME2wMlM1Ojd7IN88US=> NXf4U49HW0GQR1XS
GDM-1 NX7hZpJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M135eWlEPTB;MD6zOVExPCEQvF2= NGXaNpBUSU6JRWK=
NCI-H747 NE\ye49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrMTWM2OD1yLkO3NVA{KM7:TR?= M4\PWHNCVkeHUh?=
NCI-H1092 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEThUlJKSzVyPUCuN|g5PDRizszN NFj1PFVUSU6JRWK=
8-MG-BA MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwM{m4N|ch|ryP M2flTXNCVkeHUh?=
NB17 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHrUJJKSzVyPUCuOFI6PyEQvF2= NYTw[XRLW0GQR1XS
LC4-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjmTWM2OD1yLkSzOlA4KM7:TR?= Ml\LV2FPT0WU
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KALS-1 MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13DZ2lEPTB;MD60OlU5PCEQvF2= MWrTRW5ITVJ?
CCRF-CEM NGPRUnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nwR2lEPTB;MD60O|Y4PCEQvF2= MXTTRW5ITVJ?
OS-RC-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zYOWlEPTB;MD60O|k4OiEQvF2= NFX6R|NUSU6JRWK=
A704 NFG0b4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Dzc2lEPTB;MD60PFY6OiEQvF2= NWjCNZNIW0GQR1XS
BB49-HNC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z0PGlEPTB;MD60PVA6PiEQvF2= NVvyN|lzW0GQR1XS
EVSA-T M4HsNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwNEm5NVEh|ryP MlzQV2FPT0WU
Mo-T MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHLTWM2OD1yLkWxO|YzKM7:TR?= NWXwe2hTW0GQR1XS
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BB65-RCC NVq3V5hWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNU[4NVEh|ryP M2qycnNCVkeHUh?=
NCI-H1882 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwNUmwN|Yh|ryP MVnTRW5ITVJ?
TE-9 NG[0dlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLzTWM2OD1yLk[xNFM{KM7:TR?= M13MT3NCVkeHUh?=
NCI-H2126 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4riXmlEPTB;MD62NlY3QSEQvF2= M{XtRnNCVkeHUh?=
SF268 M2jvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrWTWM2OD1yLk[1OlQyKM7:TR?= M1LEeHNCVkeHUh?=
SW872 NIrWWWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwNkW3Nlkh|ryP NHrYWmZUSU6JRWK=
LS-513 NHm3eJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX60NGh3UUN3ME2wMlY3PzVzIN88US=> MmHUV2FPT0WU
NCI-H1355 NWXDWohmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfB[VFnUUN3ME2wMlY5PjF7IN88US=> MkDqV2FPT0WU
BL-70 NUDN[YRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[2TWM2OD1yLk[5N|g5KM7:TR?= Mk\CV2FPT0WU
NCI-SNU-5 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwNkm1OFUh|ryP NV;TbnJqW0GQR1XS
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GB-1 NGK0R2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7N[pcyUUN3ME2wMlczOTJ2IN88US=> Ml7JV2FPT0WU
CTB-1 M13TPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljuTWM2OD1yLke3PVU2KM7:TR?= MVLTRW5ITVJ?
Becker NX;rVZZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwN{m2NlEh|ryP MYHTRW5ITVJ?
KM12 NELEcWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfSclFKSzVyPUCuPFU1PjZizszN MVXTRW5ITVJ?
ES7 NFfVOnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLxbFUyUUN3ME2wMlg6PjVizszN NELXfGFUSU6JRWK=
COLO-684 NUPRdJRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\KOY9KSzVyPUCuPVA3PThizszN NEjsR2FUSU6JRWK=
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TE-10 M{D5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7vTWM2OD1yLkm2OFMh|ryP MmfDV2FPT0WU
SF126 NXPPO21pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XPVGlEPTB;MD65PFk4OSEQvF2= MnXlV2FPT0WU
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L-540 M{X4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3pZo5wUUN3ME2xMlEyQDN7IN88US=> M1\zUXNCVkeHUh?=
KURAMOCHI M1ro[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULxfXVIUUN3ME2xMlEzOzd2IN88US=> NXrhUplYW0GQR1XS
LU-65 NYjvPXIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;kdWlEPTB;MT6xNlc2OyEQvF2= NWPwU4FqW0GQR1XS
MFH-ino NIPE[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHRTWM2OD1zLkG3OVAyKM7:TR?= Mmr5V2FPT0WU
NCI-H23 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkX5TWM2OD1zLkKwOFEh|ryP NVH3Z2JzW0GQR1XS
IA-LM M163RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M133UGlEPTB;MT6yOFEyPiEQvF2= NX7ufYVRW0GQR1XS
PSN1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHqRppSUUN3ME2xMlI4ODF4IN88US=> MWPTRW5ITVJ?
NCI-H719 M1jpZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;iXGlEPTB;MT6yO|QyOSEQvF2= NV\UWllrW0GQR1XS
SW684 M3fn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrOXYlKSzVyPUGuNlg3PTlizszN MmfIV2FPT0WU
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EW-16 MnyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPNTWM2OD1zLkOxN|Q4KM7:TR?= NFzOZmZUSU6JRWK=
NCI-H128 M2Psbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{f0NWlEPTB;MT6zOVgyPCEQvF2= NGHRWVdUSU6JRWK=
HC-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPPTWM2OD1zLkO4NVch|ryP NGr5S5lUSU6JRWK=
IST-MES1 NUjZ[GV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\tN2lEPTB;MT60NFIxQCEQvF2= M1zGUXNCVkeHUh?=
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DMS-114 M2PFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzHXI9RUUN3ME2xMlQ1PTN7IN88US=> MonlV2FPT0WU
GI-1 NVPiN|IxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PMWWlEPTB;MT60O|E{OSEQvF2= NID4W2tUSU6JRWK=
NCI-H2081 NUTxTod7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmzTWM2OD1zLkW1NVk3KM7:TR?= MXXTRW5ITVJ?
LC-1F MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nPcGlEPTB;MT61OVE6QCEQvF2= NG[5V2pUSU6JRWK=
NCI-H2227 M{G2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorJTWM2OD1zLk[xOVYyKM7:TR?= NWHpcGJVW0GQR1XS
D-502MG Mmf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;pd2lEPTB;MT62O|IyOSEQvF2= NGO3eHpUSU6JRWK=
NCI-H2141 NVrEZolvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTFwNkezNVch|ryP M4j0cnNCVkeHUh?=
LS-411N MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTFwNkm4NFch|ryP MoL6V2FPT0WU
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BB30-HNC NHjSZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfJZXJKSzVyPUGuO|I3QDVizszN M1vwR3NCVkeHUh?=
TE-15 NY\xb21QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTFwOUKzO|Mh|ryP MX;TRW5ITVJ?
JVM-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjIV4lKSzVyPUGuPVM6ODRizszN NIPOPYxUSU6JRWK=
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EW-18 M4ewU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnnSnRPUUN3ME2yMlAzOzN5IN88US=> MoHrV2FPT0WU
DJM-1 NHr5VHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDQdIR4UUN3ME2yMlAzPTV{IN88US=> MnPqV2FPT0WU
no-11 NUi4NIIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDyR2lHUUN3ME2yMlA{OTB2IN88US=> M4fFW3NCVkeHUh?=
QIMR-WIL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7zSZdSUUN3ME2yMlE3PzZ{IN88US=> NFLTVpRUSU6JRWK=
MC-CAR Mo\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJwMkK5OUDPxE1? NETCeGFUSU6JRWK=
KM-H2 MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXftN|dPUUN3ME2yMlI6ODR|IN88US=> MWPTRW5ITVJ?
ECC12 Mk\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJwM{e5OEDPxE1? NWW5eJBIW0GQR1XS
HCE-T NGX4R|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDjWHVoUUN3ME2yMlQ1QDh|IN88US=> MVPTRW5ITVJ?
MFM-223 NEfVTo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\xeGlEPTB;Mj61NFg4OSEQvF2= NXTOVFZVW0GQR1XS
SW982 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknkTWM2OD1{LkWxOFgh|ryP MVfTRW5ITVJ?
KG-1 M3rjOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXwUFBKSzVyPUKuPFg4QTFizszN NWfET45xW0GQR1XS
ES4 M1jy[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7nZ2lMUUN3ME2zMlA3OTFzIN88US=> MmjnV2FPT0WU
SCC-3 Mn\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\aTWM2OD1|LkGwPFQ5KM7:TR?= NUH5d2dZW0GQR1XS
RH-1 M{\2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnYZ3c6UUN3ME2zMlM5PzR6IN88US=> NUHzZ2RVW0GQR1XS
NCI-H748 NWP3OJlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTncnpWUUN3ME2zMlQ1OjZ4IN88US=> MoP1V2FPT0WU
HCC2218 MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjpSXJKSzVyPUOuOFY6OzdizszN NXHTNmxCW0GQR1XS
MEG-01 M3fnV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHMTWM2OD1|LkW5Olgh|ryP NY\6NmhsW0GQR1XS
NB12 NWnafmhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfUWJNwUUN3ME2zMlU6QDh6IN88US=> MWrTRW5ITVJ?
SNB75 NYrsNWZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjPN41KSzVyPUOuOlAyODNizszN MX\TRW5ITVJ?
KMS-12-PE MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTvTWM2OD1|Lk[3O|I{KM7:TR?= MmPsV2FPT0WU
SKM-1 MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTNwN{GzO|Yh|ryP MW\TRW5ITVJ?
COLO-320-HSR MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH74U|JKSzVyPUOuO|U3OzRizszN MV3TRW5ITVJ?
NKM-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DMd2lEPTB;Mz63O|M4QCEQvF2= NIW5T|BUSU6JRWK=
TE-6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfDZng{UUN3ME2zMlk1PTZzIN88US=> M1P5RnNCVkeHUh?=
D-336MG NYDnOYFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\LVHBKSzVyPUSuNFEyPjZizszN M3XrTXNCVkeHUh?=
NCI-H1650 NVPHR4ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zhc2lEPTB;ND6xOVc6PyEQvF2= M1jw[XNCVkeHUh?=
ES3 NWXt[5RYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXWTWM2OD12LkOyPFI1KM7:TR?= M{\6PXNCVkeHUh?=
YT MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTRwM{W0NlQh|ryP NH\lW|lUSU6JRWK=
ES5 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTRwNECyOVUh|ryP NHWxdmVUSU6JRWK=
LB647-SCLC NG\sVGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zrR2lEPTB;ND61OlMxQCEQvF2= NEn4TnlUSU6JRWK=
HAL-01 M2DSSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTRwNUewN|Qh|ryP Mm\KV2FPT0WU
LP-1 NELWV21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf4b|UzUUN3ME20MlczOzdzIN88US=> M3POSXNCVkeHUh?=
BC-1 NVq5TYQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPoNmVKSzVyPUWuNFA1PDdizszN MVvTRW5ITVJ?
EB-3 NUfvVodwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPHTWM2OD13LkCzNFQyKM7:TR?= MkLLV2FPT0WU
GT3TKB NXjoXlJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfqS29KSzVyPUWuNVc3PjJizszN MomxV2FPT0WU
NCI-H209 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTVwMUmzOVIh|ryP NXnPRohqW0GQR1XS
BT-474 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT0TWM2OD13LkKzNVAzKM7:TR?= MX\TRW5ITVJ?
RKO MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfiTWM2OD13LkKzOFIzKM7:TR?= M2XYcHNCVkeHUh?=
SIMA M{DMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nlO2lEPTB;NT6zNFc3PSEQvF2= M3fQ[HNCVkeHUh?=
RL NFn3TlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\LV2I{UUN3ME21MlM4PTRzIN88US=> MX7TRW5ITVJ?
GCIY MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTVwNEeyN|Yh|ryP NYXHPHpiW0GQR1XS
Calu-6 M3:5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTVwNkKyJO69VQ>? MmT2V2FPT0WU
ALL-PO NGLLTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\mdWlEPTB;NT62N|c6PSEQvF2= NF\DcppUSU6JRWK=
ARH-77 Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfKclJVUUN3ME21MlY4ODh5IN88US=> NXWyU25CW0GQR1XS
A4-Fuk MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPJNHZbUUN3ME22MlA5OTF6IN88US=> NIXuSINUSU6JRWK=
NCI-H1581 M3Kz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3aTYxKSzVyPU[uNlM5PDlizszN MkHQV2FPT0WU
HUTU-80 NV3R[nNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTZwM{[4PVch|ryP MY\TRW5ITVJ?
TGW MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\DWFNKSzVyPU[uOFU2QTNizszN NVPXdW9LW0GQR1XS
SK-N-FI NF:5V|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{WwfmlEPTB;Nj60OVg2PCEQvF2= NWPUW4RXW0GQR1XS
U-266 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HDTWlEPTB;Nj61NVkzPiEQvF2= NW\BRVNDW0GQR1XS
EM-2 NIf2TmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzJTWM2OD14Lk[3NFk6KM7:TR?= NHjJbGtUSU6JRWK=
NMC-G1 M4jTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTnTWM2OD14LkexPFk2KM7:TR?= NYDzellHW0GQR1XS
KASUMI-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLPNFd{UUN3ME22Mlg1Pzh5IN88US=> NUDDblF4W0GQR1XS
NALM-6 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\5TWM2OD14Lki2O|U1KM7:TR?= NGnDSGFUSU6JRWK=
OCI-AML2 MmH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLmW4FKSzVyPUeuNFA{OjZizszN NFPJN5pUSU6JRWK=
SHP-77 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTdwMkK0N{DPxE1? M1zjWnNCVkeHUh?=
NOMO-1 M3nNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\KWFhKSzVyPUeuNlQzPTRizszN NGKwbZVUSU6JRWK=
SK-N-DZ NWTMRlJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHxfmhYUUN3ME23MlcyODh7IN88US=> MkjNV2FPT0WU
LB1047-RCC NVnUcVBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjIVXBKSzVyPUeuO|IzOzFizszN MUHTRW5ITVJ?
MZ1-PC MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTdwOE[1OVgh|ryP MlnNV2FPT0WU
NB10 M2rqVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj3eY1KSzVyPUeuPVk2PTZizszN MVTTRW5ITVJ?
RL95-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK0OIVrUUN3ME24MlExQDR{IN88US=> M1zVSHNCVkeHUh?=
OMC-1 NY\VSG5nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRThwNUKxPVEh|ryP NVfkOINvW0GQR1XS
D-283MED NWDpcVBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRThwOUG3NVkh|ryP Moq1V2FPT0WU
MC116 NWPpZXVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ixNGlEPTB;OD65O|k1KM7:TR?= NFHSXJNUSU6JRWK=
SJSA-1 MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojZTWM2OD17LkC5NFkyKM7:TR?= M3LZOnNCVkeHUh?=
JiyoyeP-2003 NYT5Z5BWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LYbWlEPTB;OT6yPVMyPyEQvF2= NFHweWxUSU6JRWK=
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CTV-1 M1\vRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\TV25HUUN3ME2xNE4xQTd7IN88US=> NHrlR5BUSU6JRWK=
NH-12 MmHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvMTWM2OD1zMD6yOFM{KM7:TR?= MXTTRW5ITVJ?
CA46 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofYTWM2OD1zMD6zOlEh|ryP NUn2TlhbW0GQR1XS
NCI-SNU-1 MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXacGhKSzVyPUGwMlQ6PjlizszN MYDTRW5ITVJ?
SCLC-21H MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\mVGlEPTB;MUCuOlU6PiEQvF2= MmLxV2FPT0WU
EC-GI-10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX25eHNiUUN3ME2xNE44ODNzIN88US=> NXTsZZFsW0GQR1XS
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NCI-H1648 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXEdGZKSzVyPUGxMlA6PjVizszN MoHzV2FPT0WU
TGBC1TKB MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDxTWM2OD1zMT60NVAzKM7:TR?= MnrBV2FPT0WU
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NOS-1 NEPwNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7NZ3VYUUN3ME2xNk4xOzR3IN88US=> NEL0OXVUSU6JRWK=
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KARPAS-422 MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly0TWM2OD1zMj63OFk3KM7:TR?= MWDTRW5ITVJ?
LU-139 M2rKR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\DcmlEPTB;MUKuPVAzPiEQvF2= MVTTRW5ITVJ?
COR-L88 M2nYbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTF{LkmzPFIh|ryP NWfXNld2W0GQR1XS
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NB13 M2rXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnUTWM2OD1zMj65O|g{KM7:TR?= MkfrV2FPT0WU
MRK-nu-1 NF3vbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELQVHlKSzVyPUGzMlE6PSEQvF2= MmXOV2FPT0WU
MHH-NB-11 NH\yNGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrvTI5KSzVyPUGzMlI6ODJizszN MU\TRW5ITVJ?
KU812 NUPIW5QyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTF|Lk[xNlQh|ryP M2TyXXNCVkeHUh?=
TE-12 NG\zPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH4TWM2OD1zMz62PVk1KM7:TR?= M3nZS3NCVkeHUh?=
NCI-N87 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\6NWlEPTB;MUOuO|M3KM7:TR?= M3L5SHNCVkeHUh?=
EB2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF|Lki1NFUh|ryP M2[5VXNCVkeHUh?=
DB MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT2TolsUUN3ME2xN{46QDh3IN88US=> NH\nNW9USU6JRWK=
697 Mln5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;VTIhpUUN3ME2xOE41PTFzIN88US=> M1PIRXNCVkeHUh?=
MSTO-211H NWfVOZk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\hOW9KSzVyPUG0Mlc1PDhizszN NE[yWmVUSU6JRWK=
JVM-2 NUH6NmlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrhUHJUUUN3ME2xOE44PzN3IN88US=> NHTKN2ZUSU6JRWK=
COLO-824 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXQZZhDUUN3ME2xOE44QTl2IN88US=> NVXicIlyW0GQR1XS
BC-3 NGrSO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLLUnJbUUN3ME2xOU4{QThizszN MmTPV2FPT0WU
BOKU Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF3Lkm2NFgh|ryP MonHV2FPT0WU
GOTO M2[yZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnXW2FOUUN3ME2xOk46PjF5IN88US=> NHXYOGtUSU6JRWK=
HCC2157 NULxXpE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXNdm5yUUN3ME2xO{41PzV3IN88US=> MkHyV2FPT0WU
LS-1034 M1XYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHNSXBNUUN3ME2xO{43QDF6IN88US=> MnvIV2FPT0WU
CAL-148 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknyTWM2OD1zNz65O|k3KM7:TR?= NET3bY1USU6JRWK=
MOLT-4 M3XMSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTF6LkiyNFgh|ryP NWTMNGNbW0GQR1XS
Daudi MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7wc|dKSzVyPUG4MlkzOzFizszN M{LZPXNCVkeHUh?=
J-RT3-T3-5 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PHdWlEPTB;MUmuOFA3PiEQvF2= M4flXnNCVkeHUh?=
KMOE-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn2WFZCUUN3ME2xPU43PDh{IN88US=> NITxXlFUSU6JRWK=
HL-60 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XwN2lEPTB;MkCuNVk3PSEQvF2= NXrZUGk5W0GQR1XS
P31-FUJ NH;oR|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDHNGRQUUN3ME2yNE41PzV|IN88US=> NEHiVpVUSU6JRWK=
IM-9 MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPvfYVKSzVyPUKwMlYzOjRizszN MVPTRW5ITVJ?
HDLM-2 M4nobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDZRpNKSzVyPUKwMlg5OjFizszN NH;CToVUSU6JRWK=
NCI-H1304 M4nQZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjPdoNKSzVyPUKxMlA{OTFizszN MlzjV2FPT0WU
NCI-H345 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD6[npKSzVyPUKxMlA3PDNizszN MXjTRW5ITVJ?
RPMI-6666 M4jNcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M336UGlEPTB;MkGuN|YxOiEQvF2= MlnnV2FPT0WU
GR-ST MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJzLkSxO{DPxE1? Ml3BV2FPT0WU
CHP-126 M3rrfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHKeo1KSzVyPUKxMlYyQDFizszN MnvLV2FPT0WU
EHEB M3jYNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJzLk[3N|Eh|ryP MV;TRW5ITVJ?
CPC-N Ml[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJ2LkCyNFEh|ryP NGTh[WlUSU6JRWK=
NB1 MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfxTWM2OD1{ND62PVM6KM7:TR?= NF;Nc4tUSU6JRWK=
LS-123 NYn2UnhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTJ2LkmwNVIh|ryP MkPTV2FPT0WU
ST486 MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHuNWZKSzVyPUK1MlEyOTNizszN MlHmV2FPT0WU
NCI-H1963 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:4fGlEPTB;Mk[uNFYzOyEQvF2= NHvaR3NUSU6JRWK=
U-87-MG M1PBWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTDTWM2OD1{Nj63OlQ1KM7:TR?= M3n0bnNCVkeHUh?=
COR-L279 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJ4Lke5NlIh|ryP NXrSU4R{W0GQR1XS
LU-165 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S1WWlEPTB;MkiuNFg3OSEQvF2= NEPJVFFUSU6JRWK=
COLO-800 NIHLR|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PpZ2lEPTB;MkiuNlk2PiEQvF2= MXrTRW5ITVJ?
ETK-1 M1fZWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fYT2lEPTB;MkiuN|Q1PiEQvF2= MlHaV2FPT0WU
LNCaP-Clone-FGC M2XKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHPTWM2OD1{OT65NlgyKM7:TR?= NIPhcJJUSU6JRWK=
SIG-M5 MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmD3TWM2OD1|MD63PVUzKM7:TR?= NIPDNYpUSU6JRWK=
NB6 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXGPJQyUUN3ME2zNE46PTB|IN88US=> NHnvOG5USU6JRWK=
NCI-H2107 MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\5cYNKSzVyPUOxMlI{OzhizszN MmTTV2FPT0WU
SNU-C1 NWP3d3p[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTNzLkOxNlYh|ryP NFryWHNUSU6JRWK=
JAR NW\FfItMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;HemlEPTB;M{GuN|c6QSEQvF2= MnPPV2FPT0WU
L-363 NVf5b4xWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTN{LkKxOFQh|ryP MXjTRW5ITVJ?
EW-24 Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3L[Jo4UUN3ME2zNk4{PDd2IN88US=> NHn0dYtUSU6JRWK=
NB69 NHfS[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHKNohKSzVyPUOzMlY1PTRizszN M135WHNCVkeHUh?=
EW-13 NIXve5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTN|Lki5Olkh|ryP NILOdY5USU6JRWK=
Ramos-2G6-4C10 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTN2LkK5PVMh|ryP NW\V[Hp[W0GQR1XS
TE-11 NVnkeZdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzTTWM2OD1|ND60PFIzKM7:TR?= MVzTRW5ITVJ?
L-428 MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLwUnNyUUN3ME2zOE44PTN4IN88US=> NIKzbFVUSU6JRWK=
KP-N-YN MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTN2LkmwOVch|ryP MXHTRW5ITVJ?
CGTH-W-1 M1PLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\VTWM2OD1|Nj65NFQ5KM7:TR?= NHjiT3RUSU6JRWK=
K-562 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWC4N|dmUUN3ME2zO{4xQDZ2IN88US=> MoHSV2FPT0WU
NCI-H1299 M{HORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorlTWM2OD1|OD6xOlA{KM7:TR?= NFPLWJJUSU6JRWK=
RCC10RGB MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG0U5hOUUN3ME2zPE4zODh|IN88US=> NWjYbHM{W0GQR1XS
NCI-SNU-16 NHLIeolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTN6LkW2OVMh|ryP M4DtOXNCVkeHUh?=
LC-2-ad MljQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrCe3pKSzVyPUO5MlQ{OzdizszN MmT0V2FPT0WU
MHH-PREB-1 NGD0WmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH6SnZKSzVyPUO5Mlc{QDhizszN MYPTRW5ITVJ?
NCI-H64 NUnkZVV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHwSnVpUUN3ME20NE4xQTR6IN88US=> M1WwcnNCVkeHUh?=
LB996-RCC M1jtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTRyLki3NVYh|ryP NV;HOGc3W0GQR1XS
DEL NVHRR4ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTRzLkS0NFUh|ryP NYniS5JQW0GQR1XS
MLMA NYDJUmlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTRzLke1PVUh|ryP MYjTRW5ITVJ?
SBC-1 M4nSSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTR{LkG4NFYh|ryP Ml3IV2FPT0WU
MPP-89 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLLTWM2OD12Mj61PFc2KM7:TR?= NXHhc4dRW0GQR1XS
MV-4-11 M1HQR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTR{LkmwOlch|ryP MX\TRW5ITVJ?
EoL-1- NILW[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO1VZVKSzVyPUS0MlE2PjhizszN NHT4NJhUSU6JRWK=
CW-2 NImzV4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rZNWlEPTB;NESuPFM1OiEQvF2= MYTTRW5ITVJ?
HT NE\2SI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rIXGlEPTB;NEWuO|AxPyEQvF2= Ml62V2FPT0WU
SW954 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK0WFg5UUN3ME20O{41OTJ6IN88US=> M2LtcHNCVkeHUh?=
A3-KAW Mnm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTR7LkiwOlEh|ryP MVzTRW5ITVJ?
TC-YIK M4LERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTVyLkCzOlMh|ryP NWf2fHJSW0GQR1XS
SW962 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLVTWM2OD13ND64N|U4KM7:TR?= M1TvRnNCVkeHUh?=
KP-N-RT-BM-1 NXm1NlRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTV4Lk[2N|gh|ryP NY[1fmUxW0GQR1XS
NCI-H1395 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTqTWxKSzVyPUW4MlgyPzJizszN MWjTRW5ITVJ?
RPMI-8402 NVPNXWpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLYTWM2OD13OD65OVI3KM7:TR?= MmfoV2FPT0WU
SCH MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrDXGs6UUN3ME22NE46PjN6IN88US=> NYjTOldbW0GQR1XS
NCI-H2196 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTZzLkKzNUDPxE1? MY\TRW5ITVJ?
LOXIMVI MmnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTj[XBTUUN3ME22NU45OjZ4IN88US=> M3u1VHNCVkeHUh?=
TGBC24TKB M2\aPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X3fGlEPTB;NkKuNVQ6OSEQvF2= MlnGV2FPT0WU
SK-MEL-2 M3XxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\GTWM2OD14Mz65PFkzKM7:TR?= NWrVPJJLW0GQR1XS
U-698-M NYjIO2RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jOd2lEPTB;NkiuOVY5PyEQvF2= NFHSWZBUSU6JRWK=
NCI-H1522 NXLjOXJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TVcmlEPTB;NkmuNFA1PyEQvF2= MVvTRW5ITVJ?
UACC-812 NHXzdnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7tTWM2OD14OT61NlA6KM7:TR?= MYnTRW5ITVJ?
MHH-CALL-2 M{W0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjUWW1KSzVyPUewMlA3KM7:TR?= NFzVdGFUSU6JRWK=
NB5 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD5TWM2OD15MD6zOFY5KM7:TR?= MYfTRW5ITVJ?
KARPAS-299 MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXGTWM2OD15MD60OFQ4KM7:TR?= MYXTRW5ITVJ?
NCI-H1694 M1LPeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnNXXFPUUN3ME23NU4xOzJizszN MXvTRW5ITVJ?
NCI-H82 M4\DN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTNTWM2OD15MT65OVA4KM7:TR?= M1Hxe3NCVkeHUh?=
SCC-15 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LpVmlEPTB;N{KuN|Qh|ryP MWrTRW5ITVJ?
NCI-H1436 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L3WGlEPTB;N{KuO|Q2PiEQvF2= M4XEW3NCVkeHUh?=
ATN-1 MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTd2LkWwOUDPxE1? Mn;4V2FPT0WU
RPMI-8866 MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTd2Lke1NFkh|ryP NWPDeWVYW0GQR1XS
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NCI-H889 NF7LcW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXiTWM2OD1zMESuNlQzKM7:TR?= MnXHV2FPT0WU
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... Click to View More Cell Line Experimental Data

In vivo試験 Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Measurement of inhibitory activities of MG-132 against 20S proteasome The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.

細胞アッセイ:

[3]

細胞株 KIM-2, HC11, and ES
濃度 Dissolved in DMSO, final concentrations ~25 μM
反応時間 24, and 48 hours
実験の流れ

Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.

動物実験:

[7]

動物モデル Male mdx (C57BL/10ScSn DMD mdx) mice
製剤 Dissolved in DMSO, and diluted in PBS
投薬量 ~10 μg/kg/day
投与方法 Injection

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download MG-132 SDF
分子量 475.62
化学式

C26H41N3O5

CAS No. 133407-82-6
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 95 mg/mL (199.73 mM)
エタノール 95 mg/mL (199.73 mM)
<1 mg/mL (<1 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate

文献中の引用 (43)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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