MG-132

製品コードS2619

MG-132化学構造

分子量(MW):475.62

文献中の引用(47)

カスタマーフィードバック(10)

  • MDA-MB-231 cells were treated with 10 uM MG132 and incubated under normoxia or hypoxia for 4 h. Endogenous interaction between LATS2 and SIAH2 was analysed by immunoprecipitation.

    Nat Cell Biol 2015 17(1), 95-103. MG-132 purchased from Selleck.

    HeLa cells were transfected with control mimic, RMND5A siRNA or miR-138 mimic. After transfection for 36 h, cells were treated with proteasome inhibitor MG132 (20 uM) or Dimethyl sulfoxide (DMSO) for 8 h. Endogenous Exportin-5 protein and RMND5A protein expression was measured by western blotting.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

  • HeLa cells were transfected with negative control mimic, miR-138 mimic or RMND5A siRNA. After transfection for 36 h, cells were treated with MG132 (20 uM) or DMSO for 8 h. RMND5A and Exportin-5 protein expression were analyzed by immunocytochemistry. Nuclei were counterstained with DAPI.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

     

    TFEB induced autophagy dependent ATZ clearance in vitro. MEF transiently co-transfected with either ATZ plus GFP expressing plasmids or ATZ plus TFEB expressing plasmids were incubated with proteasome inhibitor MG132 or with DMSO for 6 h. Upon MG132 treatment, steady state levels of 52 kDa ATZ band increased in both cells transfected with ATZ plus GFP and with ATZ plus TFEB expressing plasmids. Quantification of band intensities showed a 48% reduction of ATZ in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP, in the absence of the proteasome inhibitor. In MG132 treated cells, a 61% decrease of ATZ was detected in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP.

    EMBO Mol Med 2013 5, 397-412. MG-132 purchased from Selleck.

  • JAK1 expression was analyzed in A375 cells expressing scrambled shRNA or shRNF125 (#2) and treated with MG132 (5 uM, 10 hr), and in Lu1205 cells expressing WT RNF125 and treated with MG132.

    Cell Rep 2015 11(9), 1458-73. MG-132 purchased from Selleck.

    LRB1 and LRB2 regulate phyB protein levels. PhyB protein levels in crude extracts from the wild type (WT) and the indicated mutant backgrounds were assayed by immunoblot analysis with anti-phyB monoclonal antibodies. Anti-PBA1 and anti-histone H3 antibodies were used to confirm equal protein loading. Rc-induced loss of phyB in the wild type is inhibited by 100 uM MG132.

    Plant Physiol 2012 60(1), 118-34. MG-132 purchased from Selleck.

  • Representative images for γ-H2AX-stained cells treated with 100 uM FA for 3 h without or with MG132. Fluorescence was measured in at least 50 nuclei in each of three experiments.

    Toxicol Appl Pharmacol 2015 286(2), 135-41. MG-132 purchased from Selleck.

    GSK-3β phosphorylation at Ser9 is enhanced in NOK-overexpressed stable cell lines. The proteasome inhibitor, MG132, was added in medium of HeLa-HA and HeLa-NOK-HA cells for 12 h and then the p-GSK-3b(Ser9) was assayed by western blotting.

    FEBS Lett 2012 586, 3787–3792. MG-132 purchased from Selleck.

  • Nek2A impedes SuFu ubiquitination. HEK293T cells transfected with Nek2A-Myc and Flag-SuFu for 48 h were treated with MG-132 to enrich ubiquitinated proteins, and subsequently subjected to co-immunoprecipitation assay. Precipitated proteins were probed using anti-Ub antibody.

    Int J Oncol, 2017, 50(2):373-380. MG-132 purchased from Selleck.

    Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1-4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 μM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot).

    2012 Dr. Edison DUKE-NUS Graduate Medical School Singapore.. MG-132 purchased from Selleck.

質量管理及び製品安全説明書

Proteasome阻害剤の選択性比較

生物活性

製品説明 MG-132は一種のプロテアソーム阻害剤で、無細胞試験でIC50値が100nMですが、カルパイン(calpain)も抑制して、このIC50値が1.2μMになります。
靶点
Proteasome [1]
(Cell-free assay)
100 nM
In vitro試験

MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LPS-stimulated RAW264.7 cells MULGeY5kfGmxbjDBd5NigQ>? NG\3fZczPSEQvF2= NEfVRoxFVVOR M3v2TmlvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjFizszN NXTZVVBQOjR4OUe0PVY>
HL-60 MmLSR5l1d3SxeHnjJGF{e2G7 NVLzc|BTPDBizszN MW[0PEBp NHHqbZlFVVOR NXPWXXV3UUN3MEyxNEDPxE1? NGnXVlkzPDZ7N{S5Oi=>
SMMC-7721 MYPDfZRwfG:6aXOgRZN{[Xl? NUe2fWdUPDBizszN NWG2cY5PPDhiaB?= MYrEUXNQ MYTJR|UxRTdwMTFOwG0> MXeyOFY6PzR7Nh?=
A-549 MlHmR5l1d3SxeHnjJGF{e2G7 NU[0NpdIPDBizszN M2fxOFQ5KGh? M{DnfmROW09? MVLJR|UxRDFyIN88US=> M1jnelI1Pjl5NEm2
MCF-7 MW\DfZRwfG:6aXOgRZN{[Xl? NX;uPYxmPDBizszN MnWyOFghcA>? NGLZUZJFVVOR M1;KWWlEPTB;Nz6zJO69VQ>? NXjydoFlOjR4OUe0PVY>
SW-480 NH\KN5VEgXSxdH;4bYMhSXO|YYm= M2KzSFQxKM7:TR?= NWe4c3RjPDhiaB?= NFm5[ZRFVVOR NU[1WFh5UUN3ME20JO69VQ>? NHPWZpUzPDZ7N{S5Oi=>
NCI-H929 MV7DfZRwfG:6aXOgRZN{[Xl? M4HEPVEh|ryP M13tNVczKGh? MoXwSG1UVw>? MY\JR|UxRTBwMUeg{txO MUKyOFYzPTB6OB?=
293T NF\ZN5VEgXSxdH;4bYMhSXO|YYm= MkHxNVAh|ryP MXe3NkBp NFW1SFBFVVOR NIHmUotKSzVyPEKg{txO NUe4eHFFOjR4MkWwPFg>
293T NYS3R2JkTnWwY4Tpc44hSXO|YYm= MUWxNEDPxE1? NVLKNJcyOjRiaB?= NYPK[|hPTE2VTx?= MojLUY9l\XKjdHXsfUBqdmS3Y3XzJIhm[XRvc3jvZ4shKA>? NXzaZ48xOjR4MkWwPFg>
HeLa MY\LbY5ie2ViQYPzZZk> MoDNNVAh|ryP NXjMfm43OSCq MUPEUXNQ MYPJcoR2[2W|IGDBVnAh[2ynYY\h[4Uh[nliaX7obYJqfGmwZzDwdo9{\WG|b33lJIFkfGm4aYT5 MYWyOFMzOTh|Mx?=
MDA-MB-231 NEO5eYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rvWVEh|ryP NGDuWo44OiCq M3zPcmROW09? NXfmOG1CUUN3ME2wMlE5KM7:TR?= NInKOGozPDF3M{KwOi=>
MCF-7 Mn\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrsSW8yKM7:TR?= M3nUR|czKGh? NFPtOnFFVVOR NUjWcVJiUUN3ME2wMlE{KM7:TR?= Mk[zNlQyPTN{ME[=
MCF10A Mkf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvNNUDPxE1? Mn3vO|IhcA>? MnTJSG1UVw>? M1jhZWlEPTB;MD6yPUDPxE1? MVmyOFE2OzJyNh?=
HEK-293 MoS5T4lv[XOnIFHzd4F6 M2HFTVIh[W6mIEKwJO69VQ>? NV3GXVNVOiCq MYDEUXNQ MmCxTY5pcWKrdIOgR4hVNUxiYXP0bZZqfHlid3n0bEBKSzVyIH;mJFkhdk1i Mn\yNlM2PDB5OUC=
Calu6 MkPuSpVv[3Srb36gRZN{[Xl? NX\Q[Yg3OTBizszN M3qyWFE5KGh? NYGwV3BRTE2VTx?= M3LkfXNq\26rZnnjZY51dHliYXPjeY12dGG2ZYOg[pJifGG6aX6gdJJm[3W{c3;y NHHjSnUzOzVyNkS4Oi=>
IFN-gamma-induced RAW264.7 M123emZ2dmO2aX;uJGF{e2G7 M3\0SmROW09? NUXkeoxuUW6qaXLpeJMhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDBwMEe3JO69VQ>? NFnvb4ozOjJ5N{K3Oy=>
IPC227F NEDEc3BEgXSxdH;4bYMhSXO|YYm= NX3XNpo2OSEQvF2= MWS0PEBp MX3EUXNQ M{DTd2lEPTB;MD6wO|ch|ryP NUG0bVQ3OjF7MkS1Nlg>
Hepa-1c1c7 M{K3NmZ2dmO2aX;uJGF{e2G7 NU[ze|RnOjVizszN Mn3hOkBp NVHrXFdZTE2VTx?= MVvJcoNz\WG|ZYOgUpJnOiCycn;0[YlvKGyndnXs MUKyNFM6OjV2NB?=
COS-7 NYjzS3FkS3m2b4TvfIlkKEG|c3H5 MXexNEDPxE1? NFv4Z4lFVVOR NYrOPWRUUUN3MEyxNEDPxE1? MoCyNVgxQDhyOUe=
HuH-7 NYjje|JIS3m2b4TvfIlkKEG|c3H5 NHnNXHUyOCEQvF2= Mkm5SG1UVw>? MWDJR|UxRDFyIN88US=> Mo\aNVgxQDhyOUe=
OCI-Ly3 Ml;uSpVv[3Srb36gRZN{[Xl? NVLzZ241OTBizszNxsA> NH3PU4Y1KGh? MWfEUXNQ NUnkbGJnUW6mdXPld{BpfW2jbjDJb4FxeGGEYXzwbIEhe3SjYnnsbZpifGmxbjD3bZRpKEWFNUCgc4YhOSEQvF2= MVWxPFAzPDFzMx?=
A2780 cDDP MYDBdI9xfG:|aYOgRZN{[Xl? NVnNOVhbOjRiaB?= MofrSG1UVw>? MYPJcoR2[2W|IHHwc5B1d3OrczDifUBqdmirYnn0bY5oKFCWRV6g[IVoemGmYYTpc44> NISweIEyPzZ6NECxPC=>
LPS-stimulated RAW264.7 cells NGHLSGFHfW6ldHnvckBCe3OjeR?= NGDLfmpFVVOR NIXl[FFKdmirYnn0d{BPTi2tYYDwZWIhTE6DIHLpcoRqdmd? MWqxO|QxPzJ5Nx?=
PC12 M1PWS2Z2dmO2aX;uJGF{e2G7 MnL3NVAxKM7:TdMg M{TXTFI1KGh? M2jmUGROW09? MXvJcohq[mm2czC2MW9JTEFvIHHu[EBJOk9{LXnu[JVk\WRiY4n0c5RwgGmlaYT5 NWLzPIgxOTdzNUi0OVQ>
PC3 MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;uTmxYOjBizszN MUG0PEBp M2LU[2ROW09? Mmi1TWM2OD1yLk[g{txO NGHNZlQyPjZ6NkWzOy=>
LP-1 NYHIcVRSSXCxcITvd4l{KEG|c3H5 MUSzNFAhdk1? M{fISFI1KGh? NF;Fd5ZFVVOR MkPTTY5lfWOnczDhdI9xfG:|aYOgZpkhcW6lcnXhd4lv\yClbHXheoVlKFCDUmCgcIV3\WxiYX7kJJJm\HWlaX7nJG1kdC1zIIDyc5RmcW5ibHX2[Yw> Mlj4NVU6PTh3OEm=
ES6 NGTwVFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\tNWlEPTB;MD6wNVMxPiEQvF2= NXTofYszW0GQR1XS
A101D MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXVTWM2OD1yLkCzNlc6KM7:TR?= MYrTRW5ITVJ?
OCUB-M NYjUeJNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHIbY5GUUN3ME2wMlA{PzN5IN88US=> MWHTRW5ITVJ?
LB2518-MEL NYe5SYZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEO3OkDPxE1? NXzabppEW0GQR1XS
SH-4 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnuxTWM2OD1yLkC0N|Eh|ryP NHP5bVdUSU6JRWK=
KNS-42 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXH5V4hQUUN3ME2wMlA1PDRzIN88US=> NGfHcmVUSU6JRWK=
DSH1 MnTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M373d2lEPTB;MD6wOVI5QSEQvF2= NEGwU5dUSU6JRWK=
NTERA-S-cl-D1 NHzrWXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vBdGlEPTB;MD6wOVc4OiEQvF2= M4X1cHNCVkeHUh?=
D-542MG NGjOWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMEW5OVch|ryP M3rwTHNCVkeHUh?=
KS-1 Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHa[JFKSzVyPUCuNFY1PThizszN MXPTRW5ITVJ?
BL-41 NGrzcYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XSbWlEPTB;MD6wOlk1PyEQvF2= NXrHRYl5W0GQR1XS
LXF-289 M4jvXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPRc252UUN3ME2wMlA4ODZ4IN88US=> MmT1V2FPT0WU
D-247MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEeyNFkh|ryP NXHTRXJrW0GQR1XS
MMAC-SF M4Tofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L6UmlEPTB;MD6wO|I3QCEQvF2= Mkj4V2FPT0WU
CP66-MEL MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPFOXBKSzVyPUCuNFc2KM7:TR?= NEDpeYRUSU6JRWK=
LB771-HNC M{C0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMEiwN|Yh|ryP MmnnV2FPT0WU
no-10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S3NWlEPTB;MD6wPFkxQSEQvF2= NEftb45USU6JRWK=
A388 Ml7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDC[2FHUUN3ME2wMlA6ODZ3IN88US=> NFPiTmRUSU6JRWK=
OPM-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW0[2NXUUN3ME2wMlExPDd2IN88US=> M{XKO3NCVkeHUh?=
OVCAR-4 NFXRNYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlqyTWM2OD1yLkGwPVM5KM7:TR?= MYPTRW5ITVJ?
HOP-62 NXfJe4xYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXOVYpKSzVyPUCuNVA6PDlizszN Mn;UV2FPT0WU
ML-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX3fXRyUUN3ME2wMlEyQDB4IN88US=> M{X4UHNCVkeHUh?=
UACC-257 M17o[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHBdYNKSzVyPUCuNVE6OjdizszN NV2z[GFjW0GQR1XS
NEC8 NHOzdnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfDXWp2UUN3ME2wMlEyQTl3IN88US=> MV3TRW5ITVJ?
ONS-76 NHGxPFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnpdJJKUUN3ME2wMlEzQTN3IN88US=> MX\TRW5ITVJ?
KE-37 MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTXTWM2OD1yLkGzNlc5KM7:TR?= Mn\QV2FPT0WU
HT-144 NYf5WHExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWK2OYdVUUN3ME2wMlE{QDl3IN88US=> MX3TRW5ITVJ?
LB2241-RCC M37KSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrySYFKSzVyPUCuNVQzPDdizszN Mle3V2FPT0WU
TE-5 M3HhT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLQTWM2OD1yLkG0Nlc5KM7:TR?= Mm\jV2FPT0WU
KINGS-1 NYW3dXMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfib3FKSzVyPUCuNVQ4QSEQvF2= NHnnelhUSU6JRWK=
NCI-H69 M1PMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\CNHpSUUN3ME2wMlE2OTRzIN88US=> MojYV2FPT0WU
CAS-1 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHKeFRjUUN3ME2wMlE2PDh{IN88US=> NX;sbVBZW0GQR1XS
D-263MG NV3UXYVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnhTWM2OD1yLkG2NFA3KM7:TR?= MWLTRW5ITVJ?
A253 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMU[xNlgh|ryP NEXKcHNUSU6JRWK=
PF-382 M2K1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\1TWM2OD1yLkG2O|A3KM7:TR?= M1XBfHNCVkeHUh?=
CESS NX7GZYNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMUewOkDPxE1? NGLBTnJUSU6JRWK=
MZ2-MEL NXPyPVdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVewNWRUUUN3ME2wMlE4PTV7IN88US=> M3fyTnNCVkeHUh?=
HEL MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMUi1NVch|ryP NXTocHo5W0GQR1XS
D-392MG M2Xqfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMUmxNVUh|ryP MnvhV2FPT0WU
SK-LMS-1 NYXiUFJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMUmzNFMh|ryP MnyxV2FPT0WU
GI-ME-N NILQSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMUmzNFYh|ryP NFPSbFZUSU6JRWK=
LB831-BLC Mk\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnRTWM2OD1yLkG5N|Qh|ryP NVfHOpJrW0GQR1XS
DU-4475 NIGwbFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\RW21DUUN3ME2wMlE6PjV6IN88US=> MkCzV2FPT0WU
IST-SL1 M4W1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjISWZKSzVyPUCuNlAxQTRizszN Mnv0V2FPT0WU
GAK M2D1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMkC1N|Qh|ryP MUfTRW5ITVJ?
EW-1 NWWzRWZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof6TWM2OD1yLkKxNFQ4KM7:TR?= MlXsV2FPT0WU
LAMA-84 M3H3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;1[GlEPTB;MD6yNVg2OSEQvF2= Moj3V2FPT0WU
SK-UT-1 NXnO[mZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrreo5rUUN3ME2wMlIzODR7IN88US=> M4LQOnNCVkeHUh?=
VA-ES-BJ MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnleJF{UUN3ME2wMlIzOjV5IN88US=> NVz0XpJyW0GQR1XS
ACN MmHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm3TWM2OD1yLkKyOlM5KM7:TR?= MYrTRW5ITVJ?
SK-PN-DW M{TYUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfUTWM2OD1yLkKzNVkh|ryP MUjTRW5ITVJ?
HD-MY-Z NHzpOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3UfoZnUUN3ME2wMlI{OzB|IN88US=> NVjrVoJYW0GQR1XS
LB373-MEL-D NWfwc5V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMkSxPVgh|ryP MlLIV2FPT0WU
COLO-829 NH64SoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonRTWM2OD1yLkK0NlU4KM7:TR?= M1X2XHNCVkeHUh?=
ES8 Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;LZmlEPTB;MD6yOFc3OyEQvF2= MoKyV2FPT0WU
RXF393 NGLoT2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPOW5RKSzVyPUCuNlUxOTVizszN MW\TRW5ITVJ?
TK10 NXLpfG1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHyb21KSzVyPUCuNlU1OzVizszN NUPaOpR1W0GQR1XS
LOUCY M2G4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j3UWlEPTB;MD6yOVQ2PiEQvF2= M3vuOHNCVkeHUh?=
MZ7-mel MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULocG9WUUN3ME2wMlI3Ozd2IN88US=> NFvWcZFUSU6JRWK=
CP67-MEL MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\GOYVKSzVyPUCuNlY4OyEQvF2= M1TTWXNCVkeHUh?=
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TGW NHnMPINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M132RmlEPTB;Nj60OVU6OyEQvF2= M{jab3NCVkeHUh?=
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U-266 Mm\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITYZ|RKSzVyPU[uOVE6OjZizszN NH;tfXlUSU6JRWK=
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LB1047-RCC NUKyfmtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmWyTWM2OD15LkeyNlMyKM7:TR?= M1\ycXNCVkeHUh?=
MZ1-PC NU\0SmlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfuTWM2OD15Lki2OVU5KM7:TR?= M2fhO3NCVkeHUh?=
NB10 MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWmyUW1uUUN3ME23Mlk6PTV4IN88US=> M1PsUHNCVkeHUh?=
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OMC-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRThwNUKxPVEh|ryP M2nTSnNCVkeHUh?=
D-283MED MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRThwOUG3NVkh|ryP MV;TRW5ITVJ?
MC116 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\ocXhKSzVyPUiuPVc6PCEQvF2= NV3jdlRDW0GQR1XS
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CTV-1 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXre3ZKSzVyPUGwMlA6PzlizszN NH;jPJpUSU6JRWK=
NH-12 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEn5VHBKSzVyPUGwMlI1OzNizszN NHfXTWRUSU6JRWK=
CA46 NF;0RmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTFyLkO2NUDPxE1? MmnyV2FPT0WU
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SR MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fkV2lEPTB;MUGuNFE5PSEQvF2= MnXSV2FPT0WU
NCI-H1648 NFzqSIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULXNo02UUN3ME2xNU4xQTZ3IN88US=> NXHqepk3W0GQR1XS
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EW-11 M4fIXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXZTWM2OD1zMT61NVg3KM7:TR?= NUKyN3NiW0GQR1XS
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NCI-H524 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TGcGlEPTB;MUGuPVgzOiEQvF2= M3PSR3NCVkeHUh?=
NOS-1 M170e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF{LkCzOFUh|ryP M4DDS3NCVkeHUh?=
AM-38 NYHtU25jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:wRmlEPTB;MUKuOVY{OyEQvF2= MoPUV2FPT0WU
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COR-L88 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTF{LkmzPFIh|ryP NW\PPZF{W0GQR1XS
K5 Ml[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\3fWlEPTB;MUKuPVQ3OiEQvF2= NXm2[GEzW0GQR1XS
NB13 MmmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFizWG9KSzVyPUGyMlk4QDNizszN MVPTRW5ITVJ?
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MHH-NB-11 M3zRT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTF|LkK5NFIh|ryP MXLTRW5ITVJ?
KU812 MoLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\2TWM2OD1zMz62NVI1KM7:TR?= NYH0WINJW0GQR1XS
TE-12 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULLSJRvUUN3ME2xN{43QTl2IN88US=> M3TNb3NCVkeHUh?=
NCI-N87 NIXYblFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITDPYxKSzVyPUGzMlc{PiEQvF2= NHvaTG9USU6JRWK=
EB2 M2fSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLDTWM2OD1zMz64OVA2KM7:TR?= M{\xenNCVkeHUh?=
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JVM-2 NFXLUIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknyTWM2OD1zND63O|M2KM7:TR?= M1jN[nNCVkeHUh?=
COLO-824 M3;z[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnWTWM2OD1zND63PVk1KM7:TR?= M1HSO3NCVkeHUh?=
BC-3 NHvFbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF36WWNKSzVyPUG1MlM6QCEQvF2= MmjlV2FPT0WU
BOKU MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\K[2lEPTB;MUWuPVYxQCEQvF2= MXfTRW5ITVJ?
GOTO MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW1cm5HUUN3ME2xOk46PjF5IN88US=> MWDTRW5ITVJ?
HCC2157 NV\neYp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPGTWM2OD1zNz60O|U2KM7:TR?= MVLTRW5ITVJ?
LS-1034 Mn3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjMXJpKSzVyPUG3MlY5OThizszN NV3HN|ZwW0GQR1XS
CAL-148 NXr1eWQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF5Lkm3PVYh|ryP MonyV2FPT0WU
MOLT-4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTF6LkiyNFgh|ryP NXqwSmNtW0GQR1XS
Daudi Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPQTWM2OD1zOD65NlMyKM7:TR?= NWHLXZUxW0GQR1XS
J-RT3-T3-5 M3;GcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF7LkSwOlYh|ryP MUPTRW5ITVJ?
KMOE-2 M2LscGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjxbHhRUUN3ME2xPU43PDh{IN88US=> NV3xcWptW0GQR1XS
HL-60 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJyLkG5OlUh|ryP NX7WPHFxW0GQR1XS
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IM-9 NIjRRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPZ[4x[UUN3ME2yNE43OjJ2IN88US=> MkjkV2FPT0WU
HDLM-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVra[2k3UUN3ME2yNE45QDJzIN88US=> MnfnV2FPT0WU
NCI-H1304 NGLaXHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfrTWM2OD1{MT6wN|EyKM7:TR?= M{XFcXNCVkeHUh?=
NCI-H345 NHXmXIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTsfGhoUUN3ME2yNU4xPjR|IN88US=> MY\TRW5ITVJ?
RPMI-6666 MknGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDCOJBKSzVyPUKxMlM3ODJizszN NIPYcoNUSU6JRWK=
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CHP-126 NGjrd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJzLk[xPFEh|ryP NV;XPYIyW0GQR1XS
EHEB MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LNOWlEPTB;MkGuOlc{OSEQvF2= M3nOO3NCVkeHUh?=
CPC-N MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj6R3RrUUN3ME2yOE4xOjBzIN88US=> NIq3V4dUSU6JRWK=
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LS-123 M1:xUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3TTWM2OD1{ND65NFEzKM7:TR?= NYC3N|YzW0GQR1XS
ST486 M1iwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H6bmlEPTB;MkWuNVEyOyEQvF2= NF:ySFFUSU6JRWK=
NCI-H1963 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT6TWM2OD1{Nj6wOlI{KM7:TR?= MXfTRW5ITVJ?
U-87-MG NVvzWIZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDtOGhXUUN3ME2yOk44PjR2IN88US=> MXrTRW5ITVJ?
COR-L279 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTFdVJ7UUN3ME2yOk44QTJ{IN88US=> M{D3dHNCVkeHUh?=
LU-165 NHLoTHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LrdGlEPTB;MkiuNFg3OSEQvF2= M2HHenNCVkeHUh?=
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ETK-1 M4XI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e1eWlEPTB;MkiuN|Q1PiEQvF2= NXnueplpW0GQR1XS
LNCaP-Clone-FGC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;FTWM2OD1{OT65NlgyKM7:TR?= M1fwcXNCVkeHUh?=
SIG-M5 NV7xV5BuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4WyTmlEPTB;M{CuO|k2OiEQvF2= MYXTRW5ITVJ?
NB6 M1zYe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTNyLkm1NFMh|ryP M4rRTHNCVkeHUh?=
NCI-H2107 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TYZmlEPTB;M{GuNlM{QCEQvF2= NX\HdnJCW0GQR1XS
SNU-C1 NH\ueXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\UW5dKSzVyPUOxMlMyOjZizszN MoPZV2FPT0WU
JAR M1;3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;GTWM2OD1|MT6zO|k6KM7:TR?= MnXPV2FPT0WU
L-363 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW0fXV3UUN3ME2zNk4zOTR2IN88US=> MWLTRW5ITVJ?
EW-24 M{LW[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TIdWlEPTB;M{KuN|Q4PCEQvF2= MmPPV2FPT0WU
NB69 NGjtVpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTN|Lk[0OVQh|ryP NGfpbYdUSU6JRWK=
EW-13 M3LvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTN|Lki5Olkh|ryP NGDNZmZUSU6JRWK=
Ramos-2G6-4C10 MnHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfFWZpKSzVyPUO0MlI6QTNizszN MnzHV2FPT0WU
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L-428 NGPQeItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD1WpJHUUN3ME2zOE44PTN4IN88US=> M3;oeHNCVkeHUh?=
KP-N-YN MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml74TWM2OD1|ND65NFU4KM7:TR?= NEizbJVUSU6JRWK=
CGTH-W-1 NYflVGY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jZOGlEPTB;M{[uPVA1QCEQvF2= M2X6NHNCVkeHUh?=
K-562 M{DaSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4exbmlEPTB;M{euNFg3PCEQvF2= NHLI[YpUSU6JRWK=
NCI-H1299 Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7LTWM2OD1|OD6xOlA{KM7:TR?= NFfzfIxUSU6JRWK=
RCC10RGB MojZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ztbGlEPTB;M{iuNlA5OyEQvF2= NYXvT4R2W0GQR1XS
NCI-SNU-16 NH3ld49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK1XWlKSzVyPUO4MlU3PTNizszN NEnXTWJUSU6JRWK=
LC-2-ad M1;jU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\icWlEPTB;M{muOFM{PyEQvF2= NI\QT3BUSU6JRWK=
MHH-PREB-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DMW2lEPTB;M{muO|M5QCEQvF2= M{DWRXNCVkeHUh?=
NCI-H64 NGjPUppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXwcJZKSzVyPUSwMlA6PDhizszN NWfuWotLW0GQR1XS
LB996-RCC NGT6[41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTRyLki3NVYh|ryP M{\QXHNCVkeHUh?=
DEL Ml\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTRzLkS0NFUh|ryP NWjY[pJFW0GQR1XS
MLMA NXfnXmpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTod4hrUUN3ME20NU44PTl3IN88US=> M2fSUHNCVkeHUh?=
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MPP-89 MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HN[WlEPTB;NEKuOVg4PSEQvF2= MkfLV2FPT0WU
MV-4-11 Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[yN3JiUUN3ME20Nk46ODZ5IN88US=> NILKblZUSU6JRWK=
EoL-1- MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvCOlNZUUN3ME20OE4yPTZ6IN88US=> NYWwN2dVW0GQR1XS
CW-2 NYC0OIhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XJOGlEPTB;NESuPFM1OiEQvF2= MYjTRW5ITVJ?
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SW954 MoGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnBS4xKSzVyPUS3MlQyOjhizszN MVXTRW5ITVJ?
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TC-YIK NXXWUZFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTVyLkCzOlMh|ryP MVLTRW5ITVJ?
SW962 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITsU5VKSzVyPUW0Mlg{PTdizszN NVWzXnFSW0GQR1XS
KP-N-RT-BM-1 Mn33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXVdYJKSzVyPUW2MlY3OzhizszN NVzWTXJoW0GQR1XS
NCI-H1395 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTV6LkixO|Ih|ryP MVzTRW5ITVJ?
RPMI-8402 NWnjcYdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3JRZVRUUN3ME21PE46PTJ4IN88US=> NEnYbWtUSU6JRWK=
SCH MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjz[ZkxUUN3ME22NE46PjN6IN88US=> M3fWdHNCVkeHUh?=
NCI-H2196 NY\We3IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHrfW5KUUN3ME22NU4zOzFizszN MmnFV2FPT0WU
LOXIMVI NEDZUmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;KNItKSzVyPU[xMlgzPjZizszN NUnCW3pIW0GQR1XS
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KARPAS-299 M{DhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrZTWM2OD15MD60OFQ4KM7:TR?= M{G0d3NCVkeHUh?=
NCI-H1694 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HkdGlEPTB;N{GuNFMzKM7:TR?= NGPHeGtUSU6JRWK=
NCI-H82 M3ntfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLZTWM2OD15MT65OVA4KM7:TR?= MmDwV2FPT0WU
SCC-15 NG\FfJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTd{LkO0JO69VQ>? NVGxdHZUW0GQR1XS
NCI-H1436 NXj0b20yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTd{Lke0OVYh|ryP NWLCTpJCW0GQR1XS
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NCI-H1155 NXG2UpZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXCTWM2OD15ND65N|Y4KM7:TR?= MkXjV2FPT0WU
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NCI-H2171 MlrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PaNGlEPTB;N{muOFE{PiEQvF2= MWXTRW5ITVJ?
COLO-668 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHz[WZxUUN3ME24NU42QDh2IN88US=> MUXTRW5ITVJ?
RS4-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfYTVYyUUN3ME24Nk4zPTB3IN88US=> NFjtWmhUSU6JRWK=
NCI-H716 M1PDfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LUcWlEPTB;OEKuPVA4PSEQvF2= MVzTRW5ITVJ?
LU-134-A MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fBXWlEPTB;OEOuNVM2OSEQvF2= NVXtbIZjW0GQR1XS
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NCI-H720 NWfXWHBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\3cnB[UUN3ME25PE41ODZzIN88US=> M{fVZ3NCVkeHUh?=
NCI-H446 NVS0PZA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXzSZBKSzVyPUm5Mlc2QDhizszN NFzoSodUSU6JRWK=
NCI-H889 NUS0V4ZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\1eIFKSzVyPUGwOE4zPDJizszN NFfuZYNUSU6JRWK=
EW-22 M{TlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXJT2JNUUN3ME2xNFYvOTlizszN MV7TRW5ITVJ?
BV-173 NGfhSYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXqWmxKSzVyPUGwPE44OjhizszN MYLTRW5ITVJ?
WSU-NHL M{TtXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\2bmlEPTB;MUC5MlY4OSEQvF2= NILLUIRUSU6JRWK=
MN-60 M3vMWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTFyOT62PUDPxE1? NFjUTmRUSU6JRWK=
DG-75 MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFzMz6zOVIh|ryP MnLUV2FPT0WU
DMS-79 M1j5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2S3T2lEPTB;MUG3MlM5OiEQvF2= MmHDV2FPT0WU
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NCI-H510A M4rVUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTF{Nz6zNkDPxE1? NVq3R|hqW0GQR1XS
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KP-N-YS NE\vNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;QcJB2UUN3ME2xN|kvPzN4IN88US=> NUXnXGZWW0GQR1XS
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MDA-MB-134-VI NGnzeZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\lOGY1UUN3ME2xOFgvOjZ6IN88US=> NE\ufHlUSU6JRWK=
NCI-H1770 NIjwNppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPsTWM2OD1zNU[uNlc6KM7:TR?= Mlm4V2FPT0WU
TUR NGLaW4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;aZ3pOUUN3ME2xOlcvQDdizszN NF3ldYlUSU6JRWK=
NCI-H1417 MlTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nSV2lEPTB;MUiwMlM{OSEQvF2= Mo\lV2FPT0WU
IMR-5 NF;tWXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXBTWJzUUN3ME2xPFEvPTdzIN88US=> NYLlc2VxW0GQR1XS
NCI-H226 NHf1eI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;h[2lEPTB;MUi4Mlg3PiEQvF2= NHTabVBUSU6JRWK=
NCI-H187 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPKUW5KSzVyPUG5NE4xPjRizszN MXzTRW5ITVJ?
SF539 NU\2OZB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjZXJhKSzVyPUG5Nk44OjhizszN M3rZeXNCVkeHUh?=
TALL-1 MoHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX5S4RKSzVyPUG5PE4{ODRizszN Mo\LV2FPT0WU
TE-441-T M1;xRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3jTWM2OD1zOUmuO|M6KM7:TR?= NETUb2JUSU6JRWK=
REH Mmn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;yTVNKSzVyPUKzOk43OjZizszN MX\TRW5ITVJ?
MS-1 MoL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVryTWg3UUN3ME2yN|kvOTJzIN88US=> MXTTRW5ITVJ?
THP-1 NIG5dFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2S2XmlEPTB;Mk[0Mlc{QCEQvF2= NIeyR5pUSU6JRWK=
NCI-H1838 NIXocIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\pdmlWUUN3ME2yO|EvPDV4IN88US=> NIC4T29USU6JRWK=
P30-OHK Ml7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq2dVFmUUN3ME2yPFMvQDR5IN88US=> NHe2ZY9USU6JRWK=
C8166 NYTzfZB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[2TWM2OD1|NEWuN|M5KM7:TR?= M3vpR3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]

プロトコル(参考用のみ)

キナーゼアッセイ:

[1]

+ 展開

Measurement of inhibitory activities of MG-132 against 20S proteasome:

The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.
細胞アッセイ:

[3]

+ 展開
  • 細胞株: KIM-2, HC11, and ES
  • 濃度: Dissolved in DMSO, final concentrations ~25 μM
  • 反応時間: 24, and 48 hours
  • 実験の流れ:

    Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.


    (参考用のみ)
動物実験:

[7]

+ 展開
  • 動物モデル: Male mdx (C57BL/10ScSn DMD mdx) mice
  • 製剤: Dissolved in DMSO, and diluted in PBS
  • 投薬量: ~10 μg/kg/day
  • 投与方法: Injection
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 95 mg/mL (199.73 mM)
Ethanol 95 mg/mL (199.73 mM)
Water <1 mg/mL
体内 4% DMSO+30% PEG 300+20% propylene glycol+ddH2O 2mg/mL

* <1 mg/mlは製品が微弱に溶解する或いは溶解しないことを示します。
* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 475.62
化学式

C26H41N3O5

CAS No. 133407-82-6
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    I want to know whether it contains EDTA or other chelating agent in this product(S2619)?

  • 回答:

    Our S2619 MG-132 doesn't contain EDTA or other chelating agent.

Proteasome信号経路図

Proteasome Inhibitors with Unique Features

相関Proteasome製品

Tags: MG-132を買う | MG-132 ic50 | MG-132供給者 | MG-132を購入する | MG-132費用 | MG-132生産者 | オーダーMG-132 | MG-132化学構造 | MG-132分子量 | MG-132代理店
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID