Hesperidin 化学構造
分子量: 610.56

品質と確認

Quality Control & MSDS

製品情報

製品の説明

生物活性

Hesperidin is a flavanone glycoside found abundantly in citrus fruits. It is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. [1] In human nutrition, it contributes to the integrity of the blood vessels. Various preliminary studies reveal novel pharmaceutical properties. It reduced cholesterol and blood pressure in rats. In a mouse study, large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. Hesperidin has anti-inflammatory effects. It is also a potential sedative, possibly acting through opioid or adenosine receptors. [2][3]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

化学情報

Download Hesperidin SDF
分子量 610.56
化学式

C28H34O15

CAS No. 520-26-3
保管 2年-20℃
6月-80℃in solvent
別名 Cirantin
溶解度 (25°C) * In vitro DMSO 122 mg/mL (199.81 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-

研究分野

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