Bosutinib (SKI-606) 化学構造
分子量: 530.45

高品質保証

カスタマーフィードバック(3)

MSDS

製品説明

  • Compare Src Inhibitors
    Src製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法
  • Bosutinib (SKI-606)のメカニズム

製品の説明

生物活性

製品説明 Bosutinib (SKI-606)は一種の新たな二重Src/Abl阻害剤で、無細胞試験でIC50値が1.2 nMと1 nMです。
ターゲット

Src

Abl

IC50

1.2 nM [1]

1 nM [2]

In vitro試験 Bosutinib is selective for Src over non-Src family kinases with an IC50 of 1.2 nM, and potently inhibits Src-dependent cell proliferation with an IC50 of 100 nM. [1] Bosutinib significantly inhibits the proliferation of Bcr-Abl-positive leukemia cell lines KU812, K562, and MEG-01 but not Molt-4, HL-60, Ramos, and other leukemia cell lines, with IC50 of 5 nM, 20 nM and 20 nM, respectively, more potently than that of STI-571. Similar to STI-571, Bosutinib displays antiproliferative activity against the Abl-MLV-transformed fibroblasts with IC50 of 90 nM. Bosutinib ablates tyrosine phosphorylation of Bcr-Abl and STAT5 in CML cells and of v-Abl expressed in fibroblasts at the concentration of ~50 nM, 10-25 nM and 200 nM, respectively, leading to the Bcr-Abl downstream signaling inhibition of Lyn/Hck phosphorylation. [2] Although unable to inhibit the proliferation and survival of breast cancer cells, Bosutinib significantly decreases the motility and invasion of breast cancer cells with IC50 of ~250 nM, involved with an increase in cell-to-cell adhesion and membrane localization of β-catenin. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
NB7 NHizUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jSXmlEPTB;MD6wPFI{OSBizszN MljYV2FPT0WU
SW756 NEDx[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMUSwNlQhKM7:TR?= MnzWV2FPT0WU
CTV-1 MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3HTWM2OD1yLkG2N|k5KCEQvF2= NGjk[2ZUSU6JRWK=
HSC-4 NYPye2JrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMUexOVghKM7:TR?= MVTTRW5ITVJ?
LAMA-84 NIrmTlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{C5UWlEPTB;MD6yPFY3PCBizszN NYK3dnp2W0GQR1XS
KU812 NXLyW4Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;QTWM2OD1yLkO0NFY5KCEQvF2= MXXTRW5ITVJ?
HCC1806 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwM{WyNVYhKM7:TR?= MWfTRW5ITVJ?
DOK MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\QTWM2OD1yLkO3O|g3KCEQvF2= M13qR3NCVkeHUh?=
NCI-H209 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[yTWM2OD1yLkSwPFA5KCEQvF2= Ml3wV2FPT0WU
EoL-1-cell Mnq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LHZ2lEPTB;MD60NVU4PiBizszN NWflUpJDW0GQR1XS
H9 M2HDfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDSfG1oUUN3ME2wMlQ{PDZ2IDFOwG0> MUnTRW5ITVJ?
EM-2 NEnab2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwNEO4PUAh|ryP MoLhV2FPT0WU
NCI-H292 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzCR4lKSzVyPUCuOFQyODhiIN88US=> M1TyPHNCVkeHUh?=
697 NWXrc296T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG0ZoJKSzVyPUCuOFU3OzNiIN88US=> NGPueWtUSU6JRWK=
BHT-101 NWiwNZVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vnU2lEPTB;MD60OlU6KCEQvF2= NWnXOY5tW0GQR1XS
BE-13 MkfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi1fVZ2UUN3ME2wMlQ5PTd{IDFOwG0> MVPTRW5ITVJ?
RS4-11 NETGUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DvXWlEPTB;MD60PFU5PCBizszN NUTpS3RnW0GQR1XS
IGROV-1 M1q5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jwUGlEPTB;MD60PFc6PyBizszN MmHJV2FPT0WU
KE-37 NV;0PYhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFS5OFJKSzVyPUCuOFk2ODliIN88US=> Mn\ZV2FPT0WU
BV-173 M3P3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNUC3PVIhKM7:TR?= M{LJVHNCVkeHUh?=
MEG-01 NVPXXlR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn3V45KSzVyPUCuOVEzOTRiIN88US=> M4S3TXNCVkeHUh?=
LB2241-RCC M3viS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES4RotKSzVyPUCuOVM4OThiIN88US=> NFXjeWdUSU6JRWK=
ACHN MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7SbGhKSzVyPUCuOVQxPjliIN88US=> M3PxXnNCVkeHUh?=
CTB-1 M13jZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nPTWlEPTB;MD61OFgzKCEQvF2= MUXTRW5ITVJ?
HT-1080 NFvNcYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;hTWM2OD1yLkW1N|Q6KCEQvF2= NUPSVWQ4W0GQR1XS
CHL-1 NF\3U5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPG[ZZRUUN3ME2wMlU2PDZ3IDFOwG0> MXzTRW5ITVJ?
EW-3 NV3z[ZZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4j2TGlEPTB;MD61OVk{PSBizszN MmftV2FPT0WU
ES1 NXvRVmlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwNke0PVghKM7:TR?= MnrGV2FPT0WU
KASUMI-1 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\ubFNtUUN3ME2wMlczOzNiIN88US=> NWezZ4lNW0GQR1XS
SW13 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K1SmlEPTB;MD63N|c6QCBizszN MXHTRW5ITVJ?
A3-KAW NInNd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrrTGNKSzVyPUCuO|kzODhiIN88US=> NYDGXGpZW0GQR1XS
LB771-HNC NYDlVWg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLCTWM2OD1yLkizNVA1KCEQvF2= NIPLRlBUSU6JRWK=
OC-314 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLBTWM2OD1yLki2PVY2KCEQvF2= NVzrUI1IW0GQR1XS
MLMA MmriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXOxd3M2UUN3ME2wMlkxPjd3IDFOwG0> M1SxZnNCVkeHUh?=
KARPAS-45 NF;YS|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGyXIJ3UUN3ME2wMlkzPDZ4IDFOwG0> NHz2dZBUSU6JRWK=
CAL-27 MnL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILL[VRKSzVyPUCuPVI6ODZiIN88US=> NHrR[nNUSU6JRWK=
SK-NEP-1 MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwOUeyOFghKM7:TR?= MkfCV2FPT0WU
COR-L105 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHEepd[UUN3ME2xMlAxOzl2IDFOwG0> M2e4[XNCVkeHUh?=
TI-73 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj1bGZKSzVyPUGuNFE3PSBizszN M32zOHNCVkeHUh?=
JVM-3 M1y1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnV[lN5UUN3ME2xMlA2ODF5IDFOwG0> M3LiUnNCVkeHUh?=
HAL-01 M2naR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTFwMEi4NUAh|ryP MmXEV2FPT0WU
QIMR-WIL MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTFwMEmwOVghKM7:TR?= NYjsb4NvW0GQR1XS
HSC-3 MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3wTWM2OD1zLkGxO|g{KCEQvF2= M1[wOHNCVkeHUh?=
KY821 M1vPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\iXWlEPTB;MT6xN|M2OSBizszN MXXTRW5ITVJ?
5637 NIjiUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXtflVyUUN3ME2xMlE{QDB|IDFOwG0> Mkn2V2FPT0WU
CAL-33 NV;sO4NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;aTWM2OD1zLkG5N|AzKCEQvF2= MmS2V2FPT0WU
ES4 Mn3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\4fI1XUUN3ME2xMlIxPzliIN88US=> MUHTRW5ITVJ?
BHY MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne1TWM2OD1zLkKyPFkzKCEQvF2= Ml3OV2FPT0WU
LB1047-RCC NXS1TZJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfTbHhKSzVyPUGuNlM4QDViIN88US=> NWT2VYI1W0GQR1XS
H4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DZemlEPTB;MT6yOFI2PSBizszN M13PTnNCVkeHUh?=
RPMI-8866 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLBTWVlUUN3ME2xMlI3OTB4IDFOwG0> MkLpV2FPT0WU
HO-1-N-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\4[FhKSzVyPUGuNlY{PjliIN88US=> NVPZN3VrW0GQR1XS
BB30-HNC NIfmb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHt[lQ6UUN3ME2xMlI5PzF2IDFOwG0> M176eXNCVkeHUh?=
PC-14 M37mbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHWO284UUN3ME2xMlI6OjB3IDFOwG0> MWDTRW5ITVJ?
NUGC-3 NUnDT4VIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjiTWM2OD1zLkK5N|U3KCEQvF2= M1;zSHNCVkeHUh?=
A4-Fuk MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFq2fXdKSzVyPUGuN|A4ODRiIN88US=> NIS4bWNUSU6JRWK=
MHH-NB-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[wOmlEPTB;MT6zNVM5OyBizszN NGj2SIRUSU6JRWK=
KOSC-2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrnXlVMUUN3ME2xMlMyPzd3IDFOwG0> NGjYW3RUSU6JRWK=
A498 M{LZc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[xWFFKSzVyPUGuOFAyOTNiIN88US=> M1H3V3NCVkeHUh?=
KG-1 Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLpcHBqUUN3ME2xMlQyOjd|IDFOwG0> NVnTPG46W0GQR1XS
DEL Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLnd2V3UUN3ME2xMlQ{PjV5IDFOwG0> NFzzV5dUSU6JRWK=
EW-16 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mni0TWM2OD1zLkSzPVc{KCEQvF2= MkTJV2FPT0WU
BPH-1 M2TuW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zvc2lEPTB;MT60OFgxPSBizszN Mo\RV2FPT0WU
JAR NFfLNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYOwZZN{UUN3ME2xMlQ6OzZiIN88US=> M3r6[HNCVkeHUh?=
J-RT3-T3-5 NYXGcXNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7hdotKSzVyPUGuOVE4OjJiIN88US=> M2[4WnNCVkeHUh?=
A375 M4K3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4C0UWlEPTB;MT61NVc4OiBizszN NIDGRnlUSU6JRWK=
SW954 NY[0OHlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILwTGJKSzVyPUGuOVUxODdiIN88US=> M163XnNCVkeHUh?=
Ca9-22 NWDkOVJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzmTWM2OD1zLkW2NlYhKM7:TR?= Mm\TV2FPT0WU
D-566MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFwNUexOVUhKM7:TR?= NEmweoxUSU6JRWK=
SCC-15 M3j1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nrdmlEPTB;MT62NVgxPCBizszN NGn2R|FUSU6JRWK=
HD-MY-Z M1PxVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;oTWM2OD1zLk[zOVg1KCEQvF2= NFLyOlFUSU6JRWK=
HT-1376 NFPMNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzGT2hKSzVyPUGuOlQ{PiBizszN Mm\6V2FPT0WU
CAL-54 NXzxVpM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fiTmlEPTB;MT62OVcxQSBizszN NH3ON2FUSU6JRWK=
ONS-76 NWC5bFFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHnS4M4UUN3ME2xMlY4PTVzIDFOwG0> M4\aPHNCVkeHUh?=
EFO-27 NFTnSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorXTWM2OD1zLk[4PVIhKM7:TR?= NGXqVpFUSU6JRWK=
769-P MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXMWWpKSzVyPUGuOlk2QTZiIN88US=> NI\ibHlUSU6JRWK=
MV-4-11 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjNTWM2OD1zLk[5PFU3KCEQvF2= MWfTRW5ITVJ?
NKM-1 NY\PbINET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfFbVFKSzVyPUGuO|E5ODJiIN88US=> NYXyPIdQW0GQR1XS
LOXIMVI NXnpWIhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHITWM2OD1zLke0OVk6KCEQvF2= M1PpOnNCVkeHUh?=
KYSE-140 NVTJR2QzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fYSmlEPTB;MT63OVY2PSBizszN M323S3NCVkeHUh?=
ES5 NXW5WmZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkGwTWM2OD1zLki2O|Q4KCEQvF2= M1\aNXNCVkeHUh?=
BB65-RCC NVjJcFE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4G5c2lEPTB;MT64PVg1QSBizszN MWTTRW5ITVJ?
HN MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILRTYZKSzVyPUGuPFk5PzRiIN88US=> M4DDSHNCVkeHUh?=
A101D MoTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnnc29JUUN3ME2xMlk{PjJ6IDFOwG0> NYK0R3ZuW0GQR1XS
LoVo MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwOUe2O|khKM7:TR?= MYXTRW5ITVJ?
NCI-H526 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M162UWlEPTB;MT65PVMzPSBizszN M{Hxc3NCVkeHUh?=
NCI-H1693 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4izdmlEPTB;MT65PVg5QCBizszN MUHTRW5ITVJ?
OVCAR-4 NH\TSVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnqZ3ZQUUN3ME2yMlAxPDN3IDFOwG0> MnKwV2FPT0WU
SK-HEP-1 M3TmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[0TXVnUUN3ME2yMlAxPzR3IDFOwG0> MlvZV2FPT0WU
C2BBe1 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJwMEOzO|IhKM7:TR?= MnPKV2FPT0WU
MEL-JUSO M3XMNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfNe5Q1UUN3ME2yMlA1PDZ2IDFOwG0> M1XQXXNCVkeHUh?=
MOLT-16 M3rEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfCSWVOUUN3ME2yMlA4ODV6IDFOwG0> MkDUV2FPT0WU
NBsusSR M4LafGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTJwMEm4PFkhKM7:TR?= NGTJZ3lUSU6JRWK=
TK10 M3Lzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn2eGNKSzVyPUKuNVM1PThiIN88US=> M{OxcnNCVkeHUh?=
CAL-39 NUnCUFM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVX2OnhtUUN3ME2yMlE1PDhiIN88US=> NGXTWmhUSU6JRWK=
NCI-H2030 NFKyOYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJwMUi5O|MhKM7:TR?= NHL0RXpUSU6JRWK=
HCT-116 NYfhZlUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTlflJ4UUN3ME2yMlIzQTh2IDFOwG0> NIPjNWVUSU6JRWK=
HTC-C3 NXXFSlZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHTcmRKSzVyPUKuNlY5OjRiIN88US=> NE\2R3hUSU6JRWK=
TYK-nu M1zFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS5dWxKSzVyPUKuN|A6ODliIN88US=> M4D0bXNCVkeHUh?=
FADU M4KzVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTFTWM2OD1{LkOyNlk3KCEQvF2= MV\TRW5ITVJ?
A431 M1O5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrMTZNKSzVyPUKuN|cxOjViIN88US=> M{myVXNCVkeHUh?=
TE-11 MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfKdpZDUUN3ME2yMlM5ODF7IDFOwG0> MUTTRW5ITVJ?
CAL-12T M4CyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfPTWM2OD1{LkSwOFE4KCEQvF2= M3HOU3NCVkeHUh?=
DB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTJwNEK4OlkhKM7:TR?= NH\IW4JUSU6JRWK=
L-363 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTZTWM2OD1{LkSzOVA4KCEQvF2= MV\TRW5ITVJ?
MSTO-211H MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf5cZNjUUN3ME2yMlY3OzlzIDFOwG0> NVS3VpBLW0GQR1XS
SK-UT-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTJwN{G0NFYhKM7:TR?= MVjTRW5ITVJ?
RPMI-8226 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne2TWM2OD1{LkezNVY1KCEQvF2= M17hXnNCVkeHUh?=
SF295 NXf1bW9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rrXWlEPTB;Mj63OFMyKCEQvF2= MXXTRW5ITVJ?
OS-RC-2 M2S3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17kXWlEPTB;Mj63OlY4OyBizszN MUPTRW5ITVJ?
SK-MEL-24 NXzY[IV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfDdVFmUUN3ME2yMlc5OjJ2IDFOwG0> M4rXZXNCVkeHUh?=
COR-L23 MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrrR|NKSzVyPUKuO|k1PjRiIN88US=> M3TMd3NCVkeHUh?=
MHH-PREB-1 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M360N2lEPTB;Mj64NFE3OSBizszN NX\SZ4pSW0GQR1XS
SK-N-DZ MknKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnFboVKSzVyPUKuPFE3OzhiIN88US=> NGTXRZVUSU6JRWK=
OMC-1 NXjlNFk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILj[ZpKSzVyPUKuPFUxODNiIN88US=> MofWV2FPT0WU
SK-MEL-2 Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJwOEmyOFMhKM7:TR?= MUnTRW5ITVJ?
SAS NGS5dpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe4NWhKSzVyPUKuPVk1OTViIN88US=> Mlr6V2FPT0WU
EPLC-272H NFKxSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnSVYZKSzVyPUOuNFAzOzViIN88US=> NFTtWVlUSU6JRWK=
8505C M2KwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLQOWxKSzVyPUOuNVA{ODFiIN88US=> M3HBbXNCVkeHUh?=
EW-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fPfmlEPTB;Mz6xOFI4PyBizszN M3PH[nNCVkeHUh?=
YKG-1 NGD4RWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3PW4tKSzVyPUOuNVQ4ODZiIN88US=> M3\wXHNCVkeHUh?=
EC-GI-10 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTNwMUeyOlMhKM7:TR?= Mk\aV2FPT0WU
SK-LU-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW3PWdKSzVyPUOuNVg1OThiIN88US=> MVLTRW5ITVJ?
P30-OHK NVrt[nNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTNwMkCxNVchKM7:TR?= NXXCZZFNW0GQR1XS
T-24 NE\peHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwMkG4NVQhKM7:TR?= M2LQbnNCVkeHUh?=
HSC-2 NWL3T2JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTNwMkKyN|IhKM7:TR?= Mme3V2FPT0WU
SK-MES-1 NF3tUIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\QTWM2OD1|LkK0PFI6KCEQvF2= M4TlfXNCVkeHUh?=
SW48 NU\xXpIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWL3fmRqUUN3ME2zMlI2PDh4IDFOwG0> NVTTcno{W0GQR1XS
ME-180 NGLZd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTNwMk[wOVEhKM7:TR?= MlfYV2FPT0WU
NCI-H2009 NH[2WGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTNwMkmwNUAh|ryP MWjTRW5ITVJ?
HL-60 M17pW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\i[2lEPTB;Mz6yPVE{KCEQvF2= M4r6SHNCVkeHUh?=
NCI-N87 NHHzZ|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn6RmdKSzVyPUOuN|AyPzJiIN88US=> M3rtfXNCVkeHUh?=
GMS-10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoG3TWM2OD1|LkO0NFg3KCEQvF2= M3nFdXNCVkeHUh?=
SCH M2jhe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTNwNEC4OFQhKM7:TR?= NGXIbWNUSU6JRWK=
C-33-A MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTNwNEG0NlEhKM7:TR?= MmTpV2FPT0WU
NCI-H1703 NF22c5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm2RVZbUUN3ME2zMlQyQDF{IDFOwG0> Mln0V2FPT0WU
A427 M4PpeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD2TGNSUUN3ME2zMlQ3OTJ2IDFOwG0> MkXWV2FPT0WU
MOLT-4 M1rrbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLjTWM2OD1|LkS4NVk6KCEQvF2= M4L2TXNCVkeHUh?=
NCI-H1792 NX31PINjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\W[2lEPTB;Mz60PVgxOiBizszN NHPXUpFUSU6JRWK=
NCI-H1650 NH;3d5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;IcWtVUUN3ME2zMlU4OjliIN88US=> MX7TRW5ITVJ?
H-EMC-SS M2H3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTNwNUi1OlkhKM7:TR?= M1\DfXNCVkeHUh?=
SW982 NX;0cW1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTVVmNzUUN3ME2zMlU5QDJ7IDFOwG0> MXXTRW5ITVJ?
DSH1 M2[4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PPeWlEPTB;Mz62OFEzOiBizszN NXLXbYRGW0GQR1XS
NOS-1 NXTvOoR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTNwNkSyO|YhKM7:TR?= NGPod4ZUSU6JRWK=
BT-549 NYS2UIJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjuU3c6UUN3ME2zMlY4QDV2IDFOwG0> MYPTRW5ITVJ?
HuCCT1 NXXOOId5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X4c2lEPTB;Mz63OFE4PyBizszN M4fqWXNCVkeHUh?=
NCI-H1755 MkT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXkTWM2OD1|Lkm2PVcyKCEQvF2= Mn;GV2FPT0WU
KYSE-450 Mof5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHo[2NNUUN3ME2zMlk3QTl5IDFOwG0> NH7rZ2tUSU6JRWK=
MIA-PaCa-2 NH7XdVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PIcGlEPTB;Mz65O|I6KCEQvF2= NW\PV|ZqW0GQR1XS
U-266 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvDSGJpUUN3ME2zMlk4PDhzIDFOwG0> NVPVSXlCW0GQR1XS
Mewo M4HI[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTvTWM2OD12LkC2N|YyKCEQvF2= NEXPdYJUSU6JRWK=
KYSE-520 NEnhdlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTRwMEm3PVkhKM7:TR?= NHzvT2pUSU6JRWK=
MN-60 NXy5b4JrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTRwMUC1NFEhKM7:TR?= NUjVWWJrW0GQR1XS
Ramos-2G6-4C10 MlnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP3TXRKSzVyPUSuNVY4OzliIN88US=> NXnoZodOW0GQR1XS
SK-MEL-1 NGXYRXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nzOmlEPTB;ND6xPFY6PSBizszN MXfTRW5ITVJ?
ABC-1 NE\5RWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3tOFVKSzVyPUSuNlM{OzNiIN88US=> NX\aRVJIW0GQR1XS
CAKI-1 NVfjZY9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rKWWlEPTB;ND6yOFU4OSBizszN NInZb3NUSU6JRWK=
HOS MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTRwMkmxOFEhKM7:TR?= MoDpV2FPT0WU
SN12C MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn4SJl7UUN3ME20MlM1OjR2IDFOwG0> MWHTRW5ITVJ?
NB13 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTWSYJKSzVyPUSuN|c{PTViIN88US=> NWPHdW4zW0GQR1XS
M14 NX;KWoFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LXfGlEPTB;ND60PFc6OiBizszN M3\sZXNCVkeHUh?=
GP5d MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjlTYVKSzVyPUSuOVAyOiBizszN Mn;GV2FPT0WU
NCI-H720 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTRwNUO2NVIhKM7:TR?= Mny5V2FPT0WU
D-423MG MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTRwNUO5NlQhKM7:TR?= MUjTRW5ITVJ?
ChaGo-K-1 M{fOXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXLTWM2OD12LkW5OVU6KCEQvF2= M4TqPHNCVkeHUh?=
MEL-HO MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYmyNIdlUUN3ME20MlYyOjZzIDFOwG0> M3OxSnNCVkeHUh?=
MHH-ES-1 M4HmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[3TWM2OD12Lk[yOFEyKCEQvF2= MlL5V2FPT0WU
KYSE-270 M{HiXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\mTWM2OD12Lk[1NVI3KCEQvF2= MV\TRW5ITVJ?
GI-ME-N MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXBTWM2OD12LkexNlkyKCEQvF2= MWDTRW5ITVJ?
HOP-92 M17SZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPpSoVKSzVyPUSuPFE{PzliIN88US=> M4D3OnNCVkeHUh?=
MKN1 MknOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\6TWM2OD12LkizPVE1KCEQvF2= NXP6bGdqW0GQR1XS
ML-2 NYK3UnNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PmWWlEPTB;ND64OVYzPiBizszN M1;BUnNCVkeHUh?=
RO82-W-1 Mn\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTRwOUK5PEAh|ryP MUDTRW5ITVJ?
G-361 MmjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17sPWlEPTB;NT6wNVAxOyBizszN M1fxbXNCVkeHUh?=
HC-1 NGHYNG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\yTWM2OD13LkCzNlkyKCEQvF2= MlXIV2FPT0WU
EW-24 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr0TWM2OD13LkC0NFM5KCEQvF2= NGHT[pFUSU6JRWK=
HuP-T4 NEHZNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\GU2dpUUN3ME21MlE1OzN2IDFOwG0> NVnhZ3l[W0GQR1XS
8-MG-BA NELn[mFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoWwTWM2OD13LkO0NlghKM7:TR?= MUHTRW5ITVJ?
HGC-27 M2LJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTVwM{e2PFIhKM7:TR?= MlHNV2FPT0WU
TE-12 M{K5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfhZXlRUUN3ME21MlQyPTh3IDFOwG0> M3vGUXNCVkeHUh?=
GT3TKB M2LxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLkTWM2OD13LkS0NlEzKCEQvF2= M1uxSXNCVkeHUh?=
DOHH-2 M1TWVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qwOGlEPTB;NT60OVk5PiBizszN NEi3SVJUSU6JRWK=
Ca-Ski MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;hTWM2OD13LkS2NVE2KCEQvF2= MXXTRW5ITVJ?
A172 MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDFOm9oUUN3ME21MlU1QTJ3IDFOwG0> MmjGV2FPT0WU
EGI-1 M2TiWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTVwNUi5N|ghKM7:TR?= MXPTRW5ITVJ?
MZ2-MEL MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm5b5ZKSzVyPUWuOlE1QDZiIN88US=> MUnTRW5ITVJ?
SW1710 NWe3V2I4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X2TWlEPTB;NT62PVA6OSBizszN Mn7UV2FPT0WU
HT-144 Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHjN2JtUUN3ME21MlczPjh3IDFOwG0> MlfBV2FPT0WU
PA-1 NXzYTlBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[xTWM2OD13LkixPFk{KCEQvF2= M3;Bb3NCVkeHUh?=
HCC1937 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTVwOEO5NlkhKM7:TR?= MWTTRW5ITVJ?
SK-OV-3 NGfkfmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fud2lEPTB;NT65NVEzOSBizszN MWPTRW5ITVJ?
K5 M2\ETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTZwMEWxO{Ah|ryP M1jCd3NCVkeHUh?=
NMC-G1 M2TudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTZwMEe3PVchKM7:TR?= Mm\CV2FPT0WU
MDA-MB-361 NFP6eGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HTNWlEPTB;Nj6wPVI3OSBizszN NUG0R4d1W0GQR1XS
EKVX MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrafXV1UUN3ME22MlE{PTBzIDFOwG0> MUXTRW5ITVJ?
ES7 NXnHUpVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL2bZZKSzVyPU[uNVYyOTViIN88US=> MUnTRW5ITVJ?
KS-1 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDSPI1KSzVyPU[uNVc6QTNiIN88US=> MW\TRW5ITVJ?
NCI-H661 NGjpPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPmXodKSzVyPU[uNVgxQDFiIN88US=> NYm4OJp7W0GQR1XS
ES8 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXzTWM2OD14LkG4NFgzKCEQvF2= MUXTRW5ITVJ?
NCI-H23 NFPZU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULtWIlOUUN3ME22MlIyQDF4IDFOwG0> Mn7IV2FPT0WU
T47D NGfZbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWK3V242UUN3ME22MlI3PDV5IDFOwG0> NU\CXmFLW0GQR1XS
A2780 M3jDeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HtXGlEPTB;Nj6zO|cxOSBizszN MnnYV2FPT0WU
SCC-4 NV23Zo5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTZwNEO1OlEhKM7:TR?= M4XPeXNCVkeHUh?=
VA-ES-BJ NYjJWpB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLhTWM2OD14Lkm3NFQ{KCEQvF2= M4LiSHNCVkeHUh?=
no-11 MkfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLoNWFKSzVyPUeuNVY1OSBizszN NF3QXoVUSU6JRWK=
KU-19-19 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\NbmlEPTB;Nz6xOlQ4PiBizszN NWO3O3MyW0GQR1XS
MKN45 NUX6dohiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTdwMUi2PVkhKM7:TR?= NGnrSFZUSU6JRWK=
SCC-25 MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT2W2NnUUN3ME23MlI{PDF2IDFOwG0> MWXTRW5ITVJ?
ETK-1 M3ixTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf1SIc6UUN3ME23MlI2PTF2IDFOwG0> NV:5S|lyW0GQR1XS
COR-L88 MoXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTdwMkmzNVkhKM7:TR?= MnjrV2FPT0WU
8305C NUXNbFNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTdwM{K0PVIhKM7:TR?= MlSwV2FPT0WU
Detroit562 M4XReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTdwM{K1NFYhKM7:TR?= NHrhZWNUSU6JRWK=
SNU-449 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH1TWM2OD15LkO3OlUyKCEQvF2= MUDTRW5ITVJ?
A704 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXPTWM2OD15LkO4Nlc5KCEQvF2= NV\VVIxrW0GQR1XS
D-502MG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TJ[WlEPTB;Nz6zPFQ4OyBizszN NXz4TVROW0GQR1XS
NCI-H2228 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPITWM2OD15LkSxOFU5KCEQvF2= MljTV2FPT0WU
CHP-212 M1\vPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nCXWlEPTB;Nz61NVg6PiBizszN M1PVc3NCVkeHUh?=
VMRC-RCZ NFrJe3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HVPGlEPTB;Nz61PVA3PiBizszN M13hdXNCVkeHUh?=
RPMI-2650 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfzTWM2OD15LkewN|EzKCEQvF2= MYHTRW5ITVJ?
HCC2218 M2iyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjqS5FKSzVyPUeuO|IzPThiIN88US=> MWTTRW5ITVJ?
GCT MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr4TWM2OD15LkiyNVczKCEQvF2= Mo\tV2FPT0WU
SW780 MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHsfIVKUUN3ME23Mlk6ODZiIN88US=> M1fFR3NCVkeHUh?=
KMOE-2 M2LVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3lXllKSzVyPUiuNFQxPyBizszN MUXTRW5ITVJ?
KYSE-180 NVrPOVhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRThwMEi2OFghKM7:TR?= MUXTRW5ITVJ?
TE-1 M2S4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjteIdKSzVyPUiuNVExPTdiIN88US=> NEXBNWhUSU6JRWK=
OAW-42 NFTvbmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDV[nE6UUN3ME24MlI2PDl4IDFOwG0> MnH2V2FPT0WU
VM-CUB-1 NWTiVJp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\aOlVKSzVyPUiuNlg{PjRiIN88US=> M4joVnNCVkeHUh?=
ECC10 NH7t[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDVNVR5UUN3ME24MlI5Ozl5IDFOwG0> NVrucodOW0GQR1XS
SW1573 NX\xdnFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;0fpJKSzVyPUiuOFQ1PjViIN88US=> MWPTRW5ITVJ?
NCI-H1299 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rkVmlEPTB;OD61PVc4PCBizszN M3jFVXNCVkeHUh?=
ALL-PO Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3yfmF2UUN3ME24MlY3PTl5IDFOwG0> NHPVfnBUSU6JRWK=
OVCAR-5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTnTWM2OD16Lke3OlI2KCEQvF2= MWrTRW5ITVJ?
NCI-SNU-5 NFHuOYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRThwOEOwNFEhKM7:TR?= MknyV2FPT0WU
NCI-H2342 M4TFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfveYlKSzVyPUiuPFMyODFiIN88US=> NILlbFdUSU6JRWK=
RPMI-7951 M1Lnb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmzTWM2OD16Lki0NVU4KCEQvF2= NHTMc5VUSU6JRWK=
RCM-1 M{PJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\3cIVKSzVyPUmuNFgyPDViIN88US=> Mo\sV2FPT0WU
Daoy MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzjZWlKSzVyPUmuNVIxOjhiIN88US=> NHraeVdUSU6JRWK=
HCC1395 NHHMWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEL2PXBKSzVyPUmuN|A5QTZiIN88US=> MVTTRW5ITVJ?
786-0 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfuXoZGUUN3ME25MlM3ODJ4IDFOwG0> MVXTRW5ITVJ?
GAMG M2\EO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vBTGlEPTB;OT62OVU{PCBizszN MmfBV2FPT0WU
HCC1954 Mme0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTlwOEW4OVkhKM7:TR?= M1;UUHNCVkeHUh?=
NCI-H1838 M4fjRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3DTHhRUUN3ME25MlkxOzdzIDFOwG0> MXjTRW5ITVJ?
SW620 M{Lhcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTlwOUWzOVchKM7:TR?= NV\aOnFLW0GQR1XS
NCI-H358 MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7UTWM2OD1zMD60NVk4KCEQvF2= MlPqV2FPT0WU
NCI-H1793 Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nWVmlEPTB;MUCuOFI1QCBizszN MkXoV2FPT0WU
NCI-H1666 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTFyLkSzOVUhKM7:TR?= Mn;yV2FPT0WU
MZ7-mel NXLBbpZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPQPGVVUUN3ME2xNE41PzV|IDFOwG0> NG\5emNUSU6JRWK=
MDA-MB-175-VII M33Icmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\CSWhSUUN3ME2xNE43Ozl4IDFOwG0> NVS5OYcyW0GQR1XS
COLO-829 M4\zO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLHTWM2OD1zMD64NFA1KCEQvF2= MmruV2FPT0WU
RVH-421 MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTFzLkG1NkAh|ryP NI[1dFhUSU6JRWK=
A549 NF3vOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvvWoFKSzVyPUGxMlI1PzhiIN88US=> M{P6dXNCVkeHUh?=
DJM-1 NEnSUpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\IRllKSzVyPUGxMlM5OzNiIN88US=> M3TXeXNCVkeHUh?=
IST-MEL1 M4Li[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK5TWM2OD1zMT63N|E6KCEQvF2= M{XxS3NCVkeHUh?=
BEN MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\5TWM2OD1zMT63OFAzKCEQvF2= NFS1UJJUSU6JRWK=
KM12 M4\WNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULnUmpLUUN3ME2xNU46ODlzIDFOwG0> MnvnV2FPT0WU
HuO9 MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfaTWM2OD1zMj6wOlY3KCEQvF2= M{DseHNCVkeHUh?=
U-2-OS MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjNZW1MUUN3ME2xNk4xQDl|IDFOwG0> NWXCOJR3W0GQR1XS
RH-1 M2rKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfMV|ZKSzVyPUGyMlQ1PzJiIN88US=> MWDTRW5ITVJ?
NCI-H1048 NVj3T5BZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIS2cGtKSzVyPUGyMlU2ODZiIN88US=> MoP4V2FPT0WU
Mo-T NEe5VYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTF{LkezNFchKM7:TR?= M{nTeHNCVkeHUh?=
KYSE-150 NFXJNZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TPXGlEPTB;MUKuO|Q2PSBizszN NFjiVpVUSU6JRWK=
A388 M3nab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnDTWM2OD1zMj63O|E{KCEQvF2= MVPTRW5ITVJ?
NCI-SNU-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTF{LkiwOFYhKM7:TR?= M322T3NCVkeHUh?=
HEL Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3FPJpmUUN3ME2xNk45OjF{IDFOwG0> NUPBR|djW0GQR1XS
UM-UC-3 NXnzOpVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXifXc4UUN3ME2xNk45QDd2IDFOwG0> NHnBNmVUSU6JRWK=
TGBC24TKB MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\JRXlDUUN3ME2xN{4xOjZ5IDFOwG0> MUTTRW5ITVJ?
SW626 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTF|LkK0PFUhKM7:TR?= NFL4e5NUSU6JRWK=
ES6 Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofRTWM2OD1zMz6yOVEzKCEQvF2= NHXZU4dUSU6JRWK=
NCI-H2029 NGm5RmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYW1ZoE1UUN3ME2xN{45OTB6IDFOwG0> M2LJWnNCVkeHUh?=
RXF393 NICydYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDvfnRKSzVyPUGzMlk6OjdiIN88US=> NFXZbpdUSU6JRWK=
HMV-II NXW3RXN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;SOFNKSzVyPUG0MlA4QCBizszN MWjTRW5ITVJ?
EW-22 NYPOdIpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLrZ3lKSzVyPUG0MlE2ODJiIN88US=> NXrvVHd{W0GQR1XS
AsPC-1 NXfiT4dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF2LkW2OEAh|ryP NI\wZZpUSU6JRWK=
COLO-678 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HwPGlEPTB;MUSuO|I4OSBizszN MUXTRW5ITVJ?
HCT-15 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULtXJA4UUN3ME2xOE45QDV3IDFOwG0> NYLtendVW0GQR1XS
HCE-T MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfTSXZKSzVyPUG0Mlg5PzRiIN88US=> NXf0dYI1W0GQR1XS
SF539 NIK2[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTlbFhKSzVyPUG1MlA3PDNiIN88US=> MWfTRW5ITVJ?
AU565 NWj1WFQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDycYJvUUN3ME2xOU4zODl4IDFOwG0> MYPTRW5ITVJ?
JVM-2 M2W0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TZTGlEPTB;MUWuNlY5OSBizszN NULFWZdCW0GQR1XS
CaR-1 M1nGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jZb2lEPTB;MUWuOFQyOiBizszN MUXTRW5ITVJ?
23132-87 NGjkeWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTF3Lki0PVUhKM7:TR?= MlHnV2FPT0WU
A673 MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33xT2lEPTB;MUWuPVY{PiBizszN M1nRW3NCVkeHUh?=
KYSE-410 MnvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LEemlEPTB;MU[uNFI6KCEQvF2= M3HGNXNCVkeHUh?=
TE-9 NX;vOmN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrTRZZTUUN3ME2xOk4xPjJiIN88US=> M{PSdXNCVkeHUh?=
LU-139 M4H4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWCzUXRtUUN3ME2xOk4yQDJ|IDFOwG0> M{GyN3NCVkeHUh?=
GCIY MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS4TWM2OD1zNj6xPVE3KCEQvF2= NHXjV3hUSU6JRWK=
JEG-3 MkfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DaRmlEPTB;MU[uNlUhKM7:TR?= MVnTRW5ITVJ?
RT-112 NYrjcpVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELyWFZKSzVyPUG2MlQyPDNiIN88US=> MUjTRW5ITVJ?
COLO-680N Mlu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF4LkWxNFghKM7:TR?= M1;CTHNCVkeHUh?=
LU-134-A Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjubVJKSzVyPUG2Mlk5QTNiIN88US=> M33FO3NCVkeHUh?=
MFM-223 M2HXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHpTWM2OD1zNz6xOVM2KCEQvF2= NUi5bW5{W0GQR1XS
SF126 M{jVd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET0emhKSzVyPUG3MlE4ODFiIN88US=> MWPTRW5ITVJ?
NCI-H28 NXeycZdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETFXIdKSzVyPUG3MlIxPjZiIN88US=> MlnYV2FPT0WU
BFTC-905 NELRUnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrzPXBZUUN3ME2xO{41QDN{IDFOwG0> M{LiU3NCVkeHUh?=
SCC-9 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTF5Lk[yPFUhKM7:TR?= NYPyV5pnW0GQR1XS
KNS-62 NHuxNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rzbmlEPTB;MUeuOlYzQSBizszN NYHP[5F6W0GQR1XS
Hs-578-T M1\zPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr6PY9CUUN3ME2xO{45OTR7IDFOwG0> M{\yZnNCVkeHUh?=
D-336MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G2XWlEPTB;MUeuPFI6PCBizszN NWG3WGxMW0GQR1XS
NCI-H82 NGn1ZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLa[XZtUUN3ME2xPE4xOTh|IDFOwG0> M2HkR3NCVkeHUh?=
EFM-19 NUXPenFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{n1WmlEPTB;MUiuNFU4PyBizszN M17hdHNCVkeHUh?=
TGBC11TKB MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmmzTWM2OD1zOD6xNFIyKCEQvF2= NFjQSm5USU6JRWK=
HEC-1 MorFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q4ZWlEPTB;MUiuNlkyQCBizszN M2XoNHNCVkeHUh?=
HuP-T3 Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zxcWlEPTB;MUiuOVkzQSBizszN NWnFZ3pWW0GQR1XS
SF268 NIfaZmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF6Lk[3NFIhKM7:TR?= MlTLV2FPT0WU
COLO-792 MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrHcY91UUN3ME2xPE44QTl5IDFOwG0> NU[1RmhsW0GQR1XS
HLE NFvDcWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4O5TGlEPTB;MUiuPFM{OSBizszN MYHTRW5ITVJ?
A204 NH24SmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTjOHVuUUN3ME2xPE46OTZ2IDFOwG0> MXnTRW5ITVJ?
CAL-72 MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXOUWhKSzVyPUG5MlA5PzdiIN88US=> Mnf2V2FPT0WU
U031 M3PaVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TreWlEPTB;MUmuOFkxQSBizszN MWXTRW5ITVJ?
FTC-133 M2PO[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD0SppGUUN3ME2xPU46OzB2IDFOwG0> M2LsNXNCVkeHUh?=
SK-MEL-28 NYDyU3NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTiUoNKSzVyPUKwMlM4PjFiIN88US=> NXmwfmt[W0GQR1XS
KGN NF70[2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX5ZVI1UUN3ME2yNE41Pjl7IDFOwG0> M{PE[XNCVkeHUh?=
HCC2998 NY\KS3Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLLTmtKSzVyPUKxMlM6OjZiIN88US=> M3jqPHNCVkeHUh?=
GOTO NWTPOGNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVixNWZCUUN3ME2yNU41QDViIN88US=> NHzUdYVUSU6JRWK=
AGS MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXjXG1oUUN3ME2yNU45PDVzIDFOwG0> M2j4fnNCVkeHUh?=
EW-13 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHlc3NrUUN3ME2yNk4yODJ{IDFOwG0> NIK4b2tUSU6JRWK=
P12-ICHIKAWA MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHuwe2RKSzVyPUKyMlE3ODNiIN88US=> M1n6dXNCVkeHUh?=
NCI-H1395 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fENWlEPTB;MkKuNlkxPyBizszN Mmi4V2FPT0WU
A2058 NX\lUYU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjqRnJnUUN3ME2yNk41OzRiIN88US=> NVq4NJpoW0GQR1XS
SH-4 MmnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJ{LkewOFUhKM7:TR?= M{T4NHNCVkeHUh?=
DoTc2-4510 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\HeINKSzVyPUKzMlY1PzJiIN88US=> M4O0XXNCVkeHUh?=
MMAC-SF M2HSUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID3RoxKSzVyPUKzMlY6OTFiIN88US=> NIHSOYFUSU6JRWK=
NCI-H510A NXjJdGZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz0T5htUUN3ME2yN{44QTN7IDFOwG0> MU\TRW5ITVJ?
HDLM-2 M3q2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7MbWRKSzVyPUK0MlE1PiBizszN M37udXNCVkeHUh?=
KINGS-1 NG\NRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPPeIFKSzVyPUK0MlI1OiBizszN NX6yc21jW0GQR1XS
NCI-H1648 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3flNGlEPTB;MkSuOFAzPCBizszN NETYc5VUSU6JRWK=
HCC1187 NXry[GprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHuZYsxUUN3ME2yOU4xOjN3IDFOwG0> NGHBNGJUSU6JRWK=
BALL-1 M3XhW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH1TWM2OD1{NT6yNFYzKCEQvF2= Ml\NV2FPT0WU
SBC-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLue4h7UUN3ME2yOU4zQTl|IDFOwG0> Moj3V2FPT0WU
BFTC-909 M4DSXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXxTWM2OD1{NT6zOVUyKCEQvF2= MXTTRW5ITVJ?
MOLT-13 NEmxdYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDYTWM2OD1{NT62O|Q1KCEQvF2= MmDsV2FPT0WU
SW1990 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojYTWM2OD1{NT65OlU2KCEQvF2= NILsWlVUSU6JRWK=
DK-MG MmToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHuTWM2OD1{Nj6wOFQ{KCEQvF2= NUHoTlN[W0GQR1XS
TE-8 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXPTWM2OD1{Nj6wOlY5KCEQvF2= NUH2U5VFW0GQR1XS
Becker MoDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvSdVFKSzVyPUK2MlE2PzRiIN88US=> MV3TRW5ITVJ?
KYSE-70 M{\OfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTJ4LkWzNVchKM7:TR?= MlLmV2FPT0WU
MKN7 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LSRmlEPTB;MkeuO|Q4QSBizszN MUjTRW5ITVJ?
D-392MG NWDvZ3lZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJ5Lke2PVQhKM7:TR?= Ml;0V2FPT0WU
NH-12 NVzuXHdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfKN4FKSzVyPUK4MlEzOjliIN88US=> MojUV2FPT0WU
EW-18 NELCb|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXpbGVKSzVyPUK4MlIzOThiIN88US=> M3G4fHNCVkeHUh?=
LCLC-97TM1 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrzNVRpUUN3ME2yPE4zPzZ{IDFOwG0> NVXZPYxCW0GQR1XS
NCI-H1770 NHLVeY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTFTWM2OD1{OD6zOVY3KCEQvF2= MXzTRW5ITVJ?
BT-20 MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jLWWlEPTB;MkiuN|Y5PSBizszN MXnTRW5ITVJ?
DBTRG-05MG NX\iVndFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{CzR2lEPTB;MkiuOFg{QCBizszN MlXBV2FPT0WU
HPAF-II NGizb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1L3VmlEPTB;MkiuO|c6KCEQvF2= NFrieIVUSU6JRWK=
SW837 NU\EWJJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJ7LkOzPFUhKM7:TR?= MXnTRW5ITVJ?
647-V M4LZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJ7LkewNFMhKM7:TR?= NXS2TJNmW0GQR1XS
J82 NVLFS2pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ7LkiwNVMhKM7:TR?= MUTTRW5ITVJ?
MC116 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W4cWlEPTB;M{CuNFc{OyBizszN NWjJV3c6W0GQR1XS
NCI-H69 M1S1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfud5hKSzVyPUOwMlYxQTNiIN88US=> MVrTRW5ITVJ?
NB6 M1TTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zVN2lEPTB;M{GuN|YzQSBizszN NHzXd21USU6JRWK=
CAL-120 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfncnYzUUN3ME2zNk41OzF5IDFOwG0> M2HiNHNCVkeHUh?=
U-87-MG NVnXcFFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTtSVJbUUN3ME2zN{4xOjVzIDFOwG0> MoLwV2FPT0WU
NCI-H1304 NWr4UYZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTN|LkCzOVQhKM7:TR?= MUXTRW5ITVJ?
YH-13 MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\UOmhSUUN3ME2zN{4zPTN3IDFOwG0> NIrPdllUSU6JRWK=
RMG-I NGXRTldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fDWmlEPTB;M{OuOFI5PSBizszN NIf4RlRUSU6JRWK=
LU-65 NXP5WlN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTN2LkG0NFghKM7:TR?= MnP5V2FPT0WU
GB-1 NH7KbmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHtemJKSzVyPUO1MlA4OjliIN88US=> Mn70V2FPT0WU
DU-4475 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\QTWM2OD1|NT6xOVU{KCEQvF2= NVfUZVNtW0GQR1XS
SBC-5 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Tzb2lEPTB;M{[uOVkxOiBizszN MnvyV2FPT0WU
OE33 NWnaWIt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofMTWM2OD1|Nz63OVc4KCEQvF2= M1ex[nNCVkeHUh?=
C8166 MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLiTWM2OD1|OD61NlY4KCEQvF2= NECzZ3RUSU6JRWK=
COLO-684 NVz6SJpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHsbFF7UUN3ME2zPE44PDJ6IDFOwG0> NEj2ZYxUSU6JRWK=
NCI-H1155 M{XhN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTN7LkC0O|EhKM7:TR?= NH;PUYZUSU6JRWK=
ATN-1 MojiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfMW5ZKSzVyPUO5Mlc4QTJiIN88US=> Mm\xV2FPT0WU
KARPAS-299 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[0TWM2OD1|OT64N|khKM7:TR?= NGnocplUSU6JRWK=
KNS-81-FD MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPEe2c3UUN3ME20NE4{PjB2IDFOwG0> M37UUnNCVkeHUh?=
NCI-H1563 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn2TWM2OD12MT61NFM6KCEQvF2= MnvuV2FPT0WU
NB14 NIXQd4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fRSmlEPTB;NEKuO|I3OyBizszN MXzTRW5ITVJ?
COLO-800 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTR{Lki1NVchKM7:TR?= NIjFc|BUSU6JRWK=
MS-1 MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTR|LkC0PFMhKM7:TR?= NXj6O3hpW0GQR1XS
OVCAR-8 NUnSTnA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jVd2lEPTB;NEOuOlgxQSBizszN MXPTRW5ITVJ?
SK-PN-DW NEj3VXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrSTWM2OD12Mz64O|c3KCEQvF2= MVLTRW5ITVJ?
G-402 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrMTWM2OD12Mz65NFA3KCEQvF2= MXTTRW5ITVJ?
NCI-H2291 NGHKXZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r4WmlEPTB;NESuPFAyPyBizszN NYjBO4xtW0GQR1XS
PC-3 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfIXohKSzVyPUS1MlgxOjNiIN88US=> NILPbHJUSU6JRWK=
NCI-H1581 Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTR3Lkm4PFkhKM7:TR?= NFzmc|hUSU6JRWK=
SW1116 NUXOflRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7WTWM2OD12Nz6wNVgzKCEQvF2= MV;TRW5ITVJ?
ZR-75-30 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDVdWVSUUN3ME20O{4xOjN7IDFOwG0> MorZV2FPT0WU
OCI-AML2 MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33WbmlEPTB;NEeuNFkyQCBizszN NYS2W|R6W0GQR1XS
MDA-MB-231 M{nOdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3HbYRKSzVyPUS3MlYzPDliIN88US=> NGO1XYVUSU6JRWK=
ES3 M2foUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR6LkO1NlkhKM7:TR?= NWPWfJpoW0GQR1XS
NCI-H630 MkX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fUbGlEPTB;NEmuNVc1OiBizszN MnjCV2FPT0WU
OE19 NH7wUZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTR7LkK5NFIhKM7:TR?= NUOyPFhKW0GQR1XS
NCI-H1573 NGn2[mhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi2T4ROUUN3ME20PU43QDZzIDFOwG0> NFjCdWdUSU6JRWK=
EW-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPCVm5KSzVyPUS5MlkxQDRiIN88US=> NVvRb5BmW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 Bosutinib (60 mg/kg/day) is active against Src-transformed fibroblasts xenografts and HT29 xenografts in nude mice with T/C of 18% and 30%, respectively. [1] Oral administration of Bosutinib for 5 days significantly suppresses K562 tumor growth in mice in a dose-dependent manner, with the large tumors eradicated at dose of 100 mg/kg and tumor free at 150 mg/kg without overt toxicity. [2] As being inactive against Colo205 xenografts in nude mice at 50 mg/kg twice daily, Bosutinib dosing at 75 mg/kg twice daily is necessary against Colo205 xenografts, and increasing the dose of Bosutinib has no additional benefit, in contrast to the significant dose-dependent ability against HT29 xenografts. [4]
臨床試験 A Phase I study to compare the Bosutinib clinical tablet and clinical capsule and to investigate food effect on Bosutinib commercial formulation in healthy subjects has been completed.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

The Src and Abl kinase assays The Src kinase activity is measured in an ELISA format. Src (3 units/reaction), reaction buffer (50 mM Tris-HCl pH 7.5, 10 mM MgCl2, 0.1 mM EGTA, 0.5 mM Na3VO4) and cdc2 substrate peptide are added to various concentration of Bosutinib and incubated at 30 °C for 10 minutes. The reaction is started by the addition of ATP to a final concentration of 100 μM, incubated at 30 °C for 1 hour and stopped by addition of EDTA. Instructions from the manufacturer are followed for subsequent steps. The Abl kinase assay is performed in a DELFIA solid phase europium-based detection assay format. Biotinylated peptide (2 μM) is bound to streptavidin-coated microtitration plates for 1.5 hours in 1 mg/mL ovalbumin in PBS. The plates are washed for 1 hour with PBS/0.1% Tween 80, followed by a PBS wash. The kinase reaction is incubated for 1 hour at 30°C. Abl kinase (10 units) is mixed with 50 mM Tris-HCl (pH 7.5), 10 mM MgCl2, 80 μM EGTA, 100 μM ATP, 0.5 mM Na3VO4, 1% DMSO, 1 mM HEPES (pH 7.0), 200 μg/mL ovalbumin and various concentration of Bosutinib. The reaction is stopped with EDTA at a final concentration of 50 mM. The reaction is monitored with Eu-labeled phosphotyrosine antibody and DELFIA enhancement solution.

細胞アッセイ:

[2]

細胞株 Abl-MLV, Rat 2, KU812, K562, and MEG-01 cells
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 72 hours
実験の流れ

Cells are exposed to various concentrations of Bosutinib for 72 hours. Anchorage-independent proliferation of Abl-MLV-transformed fibroblasts is measured in 96-well ultra-low binding plates treated with Sigmacote to block residual cell attachment. Cell proliferation is measured with MTS or Cell-Glo. For the determination of cell cycle or cell death, cells are prepared for FACS analysis in the CycleTest Plus DNA reagent kit and analyzed on a fluorescence-activated cell sorter flow cytometer.

動物実験:

[2]

動物モデル Nude female mice injected with K562 cells
製剤 Suspended in 0.5% methocel/0.4% Tween 80
投薬量 ~150 mg/kg/day
投与方法 Oral gavage

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Bosutinib (SKI-606) SDF
分子量 530.45
化学式

C26H29Cl2N5O3

CAS No. 380843-75-4
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 100 mg/mL (188.51 mM)
Ethanol 2 mg/mL (3.77 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 10mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4-(2,4-dichloro-5-methoxyphenylamino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile

文献中の引用 (14)

Frequently Asked Questions

  • Question 1
    Can I give S1014 Bosutinib to mice by oral gavage? If so, how to dissolve the drug?

    Answer: For oral gavage, S1014 Bosutinib can be dissolved in 5% Tween 80+0.5% CMC Na at 30 mg/ml as a suspension.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related Src 阻害剤

  • Dasatinib Monohydrate

    Dasatinib Monohydrateは一種の新たで、有効な多ターゲット阻害剤で、Abl、Srcとc-Kitに作用する時のIC50値が1 nM以下、0.8 nMと79 nMにそれぞれ分かれることです。

  • SU6656

    SU6656は一種の選択性的なSrc家族キナーゼ阻害剤で、Src、Yes、LynとFynに作用する時の IC50値が280 nM、20 nM、130 nMと170 nMにそれぞれ分かれることです。

  • PX-478 2HCl

    PX-478 2HClは一種の経口活性をしている、選択性的なHIF-1α阻害剤です。臨床1期。

  • Defactinib (VS-6063, PF-04554878)

    Defactinib (VS-6063, PF-04554878)は一種の選択性的で、経口有効なFAK阻害剤です。臨床2期。

  • Saracatinib (AZD0530)

    Saracatinib (AZD0530)は一種の有効なSrc阻害剤で、無細胞試験でIC50値が2.7 nMです。Saracatinib (AZD0530)はc-Yes、Fyn、Lyn、Blk、FgrとLckにも活性をしていますが、AblとEGFR (L858RとL861Q)に作用する活性が低いです。臨床2/3期。

    Features:The 1st Src inhibitor to show inhibition of the Src pathway in human tumor tissue.

  • Dasatinib

    Dasatinibは一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、Srcとc-Kitに作用する時のIC50値が1 nM以下、0.8 nMと79 nMにそれぞれ分かれることです。

  • KX2-391

    KX2-391は初めの臨床Src阻害剤(ペプチド模倣型)で、Srcのペプチド基質サイトに作用することです。KX2-391は癌細胞系にGI50値が9-60 nMです。臨床2期。

  • PP1

    PP1は一種の有効で、選択性的なSrc阻害剤で、Lck/Fynに作用する時のIC50値が5 nM/6 nMです。

  • PP2

    PP2は一種のSrc家族キナーゼ阻害剤で、無細胞試験でLck/Fynに作用する時のIC50値が4 nM/5 nMです。PP2は、Srcに作用する効果はEGFRに作用する効果より100倍が高くなりますが、ZAP-70、JAK2とPKAに活性を表しません。

最近チェックしたアイテム

Tags: Bosutinib (SKI-606)を買う | Bosutinib (SKI-606)供給者 | Bosutinib (SKI-606)を購入する | Bosutinib (SKI-606)費用 | Bosutinib (SKI-606)生産者 | オーダーBosutinib (SKI-606) | Bosutinib (SKI-606)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ