Bortezomib (PS-341) 化学構造
分子量: 384.24

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MSDS

製品説明

  • Compare Proteasome Inhibitors
    Proteasome製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Bortezomib (PS-341)は、強力なプロテアソーム阻害剤で、Kiが0.6nMです。
ターゲット

20S proteasome

IC50

0.6 nM (Ki) [1]

In vitro試験 Bortezomib, a boronic acid dipeptide, is a highly selective, reversible inhibitor of the 26S proteasome which primarily functions in the degradation of mis-folded proteins and is essential for the regulation of the cell cycle. Exposure to Bortezomib has been shown to stabilize p21, p27, and p53, as well as the proapoptotic Bid and Bax proteins, caveolin-1, and inhibitor κB-α, which prevents activation of nuclear factor κB-induced cell survival pathways. Bortezomib also promotes the activation of the proapoptotic c-Jun-NH2 terminal kinase, as well as the endoplasmic reticulum stress response. Alteration of the levels of these cellular proteins leads to inhibition of proliferation, migration, and promotion of apoptosis of cancer cells. [2] Bortezomib is shown to penetrate into cells and inhibit proteasome-mediated intracellular proteolysis of long-lived proteins with a concentration that inhibits 50% of the proteolysis of ∼0.1 μM. The average growth inhibition of 50% value for Bortezomib across the entire panel of 60 cancer cell lines derived from multiple human tumors from the US National Cancer Institute (NCI) is 7 nM. Treatment of PC-3 cells with Bortezomib (100 nM) for 8 h results in the accumulation of cells in G2-M, with a corresponding decrease in the number of cells in G1. Bortezomib kills PC-3 cells at 24 and 48 hr with IC50 of 100 and 20 nM, respectively. Bortezomib induces nuclear condensation at 16–24 hr after treatment. Bortezomib treatment leads to PARP cleavage in a time-dependent manner with concentrations as low as 100 nM being effective at 24 hr. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
MCF-7 NX;LWIw{S3m2b4TvfIlkKEG|c3H5 MWq1NEDPxE1? MX60PEBp M4rzPGROW09? MmC0T4ltdHNiY3XscJMh[nlibX;y[UB1cGGwIEm5KS=> MUWxNFQ6QTZ2Mx?=
OVCA 429 MkDSSpVv[3Srb36gRZN{[Xl? NIridJI{ODBibl2= MUi0PEBp NIPYSG1FVVOR NHzkdWNFcXO{dYD0d{BqdnSjY4SgcZVtfGmlZXzseYxieiC2dX3vdkB{eGincn;p[JM> NI\wUWMyODl7OUe2Oi=>
RPMI8226 MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnlSJkyODBibl2= M1;TVVQ5KGh? M2O3bmROW09? NHG5OotKSzVyPUOwJI5O NWHLSFdHOTF|ME[0PFk>
Dox40 NFnsWYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvETHBtOTByIH7N M4\rSVQ5KGh? MXHEUXNQ M13sS2lEPTB;NECgcm0> M3[5PVEyOzB4NEi5
MR20 NXP1UFBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLENVAxKG6P M2fDNlQ5KGh? M{D5WGROW09? NEHmUVhKSzVyPUKwJI5O MlXINVE{ODZ2OEm=
LR5 NVPlN|VPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIH3XZEyODBibl2= M3zrRVQ5KGh? M2nSNGROW09? NXnrd2t6UUN3ME2yNEBvVQ>? NGjEXnYyOTNyNkS4PS=>
U266 NHLmV41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj1emlWOTByIH7N NF7x[G41QCCq NX;Jb2lJTE2VTx?= MkjwTWM2OD1|IH7N M3\HXFEyOzB4NEi5
IM-9 NHzuc3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH3dopSOTByIH7N NXLuVnFPPDhiaB?= NIjZZ|FFVVOR M1HJcWlEPTB;NjDuUS=> MWOxNVMxPjR6OR?=
Hs Sultan MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUixNFAhdk1? Mn3jOFghcA>? MYfEUXNQ MV3JR|UxRTJyIH7N MYGxNVMxPjR6OR?=
PAM-LY2 M1;rcWZ2dmO2aX;uJGF{e2G7 MmC3NVAxKG6P MknRNVIhcA>? M1vLZmROW09? MYjJcohq[mm2czDOSk3PwkJiYXP0bZZifGmxbh?= MUGxNVM2ODlzMx?=
PAM 212 NFrnRopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTrNVAxKG6P NILJTpY4OiCq MX3EUXNQ NGjBRnJKdmirYnn0d{Bk\WyuII\pZYJqdGm2eR?= Mn3wNVE{PTB7MUO=
PAM-LY2 NWfU[nAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljoNVAxKG6P M{XDfFczKGh? MlP2SG1UVw>? MWPJcohq[mm2czDj[YxtKH[rYXLpcIl1gQ>? M1vVdlEyOzVyOUGz
B4B8 NXizeGFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe4NVAxKG6P M4jJdFczKGh? MnvpSG1UVw>? NH\Hb2RKdmirYnn0d{Bk\WyuII\pZYJqdGm2eR?= NYDsXpF1OTF|NUC5NVM>
B7E3 NWDib5dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TocVExOCCwTR?= NUH5eVc1PzJiaB?= NVS1bIg{TE2VTx?= MnrRTY5pcWKrdIOgZ4VtdCC4aXHibYxqfHl? NX;IZVFjOTF|NUC5NVM>
UM-SCC-9 MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nES|ExOCCwTR?= NH;JO2M4OiCq M2rFe2ROW09? NFvBZ4xKdmirYnn0d{Bk\WyuII\pZYJqdGm2eR?= NIDqc4wyOTN3MEmxNy=>
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H460 MWPGeY5kfGmxbjDBd5NigQ>? MoqwNVAh|ryP M3\kfVI1KGh? MYLEUXNQ MUXJcoR2[2W|IFLjcE0zKHCqb4PwbI9zgWyjdHnvckBidmRiY3zlZZZi\2ViY3;ydoVt[XSnZDD3bZRpKEd{LV2gdIhie2ViYYLy[ZN1 MnKzNVI1QTJzMUe=
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ARH77 Ml;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Lsb|UxOCCwZz;tcC=> MYC0PEBp MUjEUXNQ M2\oemlvcGmkaYTzJINmdGxiZ4Lve5Rp NF;Yc|MyOjZ|MU[xPS=>
WAD-1 NG\jSJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjJXlBUPTByIH7nM41t NGjCZZQ1QCCq M176d2ROW09? MkXXTY5pcWKrdIOgZ4VtdCCpcn;3eIg> MXuxNlY{OTZzOR?=
U266/LR7 NISwfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInaT2U2ODBibnevcYw> MnftOFghcA>? M1TzfWROW09? M364ZWlvcGmkaYTzJINmdGxiZ4Lve5Rp NHnGeoIyOjZ|MU[xPS=>
U266/dox4 NYnpTGR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVK1NFAhdmdxbXy= NVnBe5BlPDhiaB?= MkTBSG1UVw>? MYLJcohq[mm2czDj[YxtKGe{b4f0bC=> NIixRpkyOjZ|MU[xPS=>
RPMI8226/LR5 NFLTRmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLsOVAxKG6pL33s MnfkOFghcA>? NF3h[2lFVVOR M2[0dGlvcGmkaYTzJINmdGxiZ4Lve5Rp NEPTV3QyOjZ|MU[xPS=>
H460 NILRbGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nIV|ExKM7:TR?= NYjVfJRyPzJiaB?= MYjEUXNQ Mnq3TWM2OD1zMECgcm0> MkL5NVI3OzF4MkC=
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H460 NHjKbWpHfW6ldHnvckBCe3OjeR?= NUTlbWNCOTByIH7N M4ewSlI1KGh? MnvMSG1UVw>? MXfJcoR2[2W|IFeyMW0ueGijc3WgZZJz\XO2IHHu[EB1fWK3bHnuJIF{e2WvYnz5MYRqe2G|c3XtZox6 MojWNVI3OzF4MkC=
LNCap-Pro5 M3OyOGZ2dmO2aX;uJGF{e2G7 MU[xJO69VQ>? MljROEBp NVn3eVl2TE2VTx?= NUDoN5FwW3SjYnnsbZpmeyCyNUO= NUPqUG96OTR4MUK1N|I>
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T29Kt1 MX;BdI9xfG:|aYOgRZN{[Xl? M{W2PVUxKG6P MVG0PEBpKA>? NV\oXoIzTE2VTx?= MV7JcoR2[2W|IHPlcIwh[XCxcITvd4l{ M4\vZ|E3Pzd6MUe5
HCT116 NVvJVnVqSXCxcITvd4l{KEG|c3H5 MkizOVAhdk1? Ml3hOFghcCB? NXrtVFdrTE2VTx?= M13YVmlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? MXqxOlc4QDF5OR?=
HKe-3 NUT4SWFFSXCxcITvd4l{KEG|c3H5 NV22cJJrPTBibl2= M3TM[lQ5KGhi NW[zTXNPTE2VTx?= NITNeotKdmS3Y3XzJINmdGxiYYDvdJRwe2m| MWqxOlc4QDF5OR?=
NB-1691 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\ySo8yKM7:TR?= Mnj5O|IhcA>? NYfRWlRCUW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKHSxIEWl NVfLbYpbOTd4OEm2PFQ>
CHLA-255 M4S5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTzNUDPxE1? MmfWO|IhcA>? NWnEVGhJUW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKHSxIEKl M4HKXlE4Pjh7Nki0
SK-N-AS NFvQfFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Pub|Eh|ryP MoXyO|IhcA>? MYrJcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36geI8hOTBn MWSxO|Y5QTZ6NB?=
NB-1691 NI\ETnRHfW6ldHnvckBCe3OjeR?= MXixNEBvVQ>? NEK2eXgzPCCq NU[zW|JUW2mpbnnmbYNidnSueTDy[YR2[2W|IHPlcIx{KGmwIITo[UBIOC:JMTDwbIF{\Q>? NG\JWGsyPzZ6OU[4OC=>
CHLA-255 NYLEOZAzTnWwY4Tpc44hSXO|YYm= MWixNEBvVQ>? NILIco4zPCCq MYPNc4Rme3SueTDy[YR2[2W|IHPlcIx{KGmwIITo[UBIOC:JMTDwbIF{\Q>? NVLXWplmOTd4OEm2PFQ>
RPMI 8226 M3S0XmZ2dmO2aX;uJGF{e2G7 MknkNlAhdk1? MmTWPEBp MVjTbYdvcW[rY3HueIx6KGWwaHHuZ4V{KE6ILd86RkBi[3Srdnn0fS=> NGG5Z2kyQTR|NkC1NC=>
MM.1S M1fneGZ2dmO2aX;uJGF{e2G7 M2\lZ|IxKG6P M{DYe|ghcA>? MkPrV4lodmmoaXPhcpRtgSCnbnjhcoNmeyCQRj5OvmIh[WO2aY\peJk> M1zFO|E6PDN4MEWw
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OPM1 MoT5SpVv[3Srb36gRZN{[Xl? MXuyNEBvVQ>? Mlm3PEBp MXzTbYdvcW[rY3HueIx6KGWwaHHuZ4V{KE6ILd86RkBi[3Srdnn0fS=> NWL1eFJ4OTl2M{[wOVA>
INA6 NV3BZ25mTnWwY4Tpc44hSXO|YYm= NYjuRmhlOjBibl2= MmPXPEBp Mn\jV4lodmmoaXPhcpRtgSCnbnjhcoNmeyCQRj5OvmIh[WO2aY\peJk> Mn63NVk1OzZyNUC=
OPM2 M4jXUGZ2dmO2aX;uJGF{e2G7 NFP1WIozOCCwTR?= M4nGRlghcA>? NFXDU2JUcWewaX\pZ4FvfGy7IHXubIFv[2W|IF7GMe67SiCjY4Tpeol1gQ>? MYWxPVQ{PjB3MB?=
RPMI 8226 MUnGeY5kfGmxbjDBd5NigQ>? NYDlW|VTOjBibl2= NWezXmpXQCCq NWLzTHZbUW6mdXPld{BFVkFic4nueIhme2m| MoDiNVk1OzZyNUC=
BaF/3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjPbXFnOTByIH7N NYe3SWZKPDhiaB?= NV63fZhzUUN3ME22MlIhdk1? MX2yNFMxPTZ7Mh?=
BaF/3-p210 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fMelExOCCwTR?= MYm0PEBp MYHJR|UxRTRwNzDuUS=> MYmyNFMxPTZ7Mh?=
TCC-S NEjJZ3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\CbVExOCCwTR?= MYe0PEBp Mn;lTWM2OD1{Lkigcm0> M4\0dlIxOzB3Nkmy
BaF/3 MWPGeY5kfGmxbjDBd5NigQ>? MVS2JI5O M3XsRlQ5KGh? M3qwbWlv\HWlZYOgZUBoemWjdDDHNUBk\WyuLXP5Z4xmKGG{cnXzeC=> NHrCfnAzODNyNU[5Ni=>
BaF/3-p210 NIHBUoZHfW6ldHnvckBCe3OjeR?= MnzvOkBvVQ>? M{f3flQ5KGh? MkGxTY5lfWOnczDhJJNtcWeqdDDHNUBk\WyuLXP5Z4xmKGG{cnXzeC=> MYKyNFMxPTZ7Mh?=
BaF/3-p210 MYPGeY5kfGmxbjDBd5NigQ>? MYG2JI5O M3zEZVI1KGh? NH76XIpT\WS3Y3XzJJRp\SCyaH;zdIhwenmuYYTpc44h[W6mIITo[UBi[3Srdnn0fUBw\iCUYh?= M4\TNFIxOzB3Nkmy
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LCL-2 Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DFO|Eh|ryP MVWyOEBp MVTS[YR2[2W|IHPlcIwhfmmjYnnsbZR6yqB? MVqyNVE4ODl6OB?=
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SNT-13 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zlSlEh|ryP NXjae|NqOjRiaB?= NHLvdFZT\WS3Y3XzJINmdGxidnnhZoltcXS7wrC= M4XBcFIyOTdyOUi4
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Jurkat MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjuNUDPxE1? MYGyOEBp NXjNWpdKWmWmdXPld{Bk\WyuII\pZYJqdGm2edMg NYjme45vOjFzN{C5PFg>
KAI-3 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS1cmoyKM7:TR?= NHjTT24zPCCq NF3JXGZT\WS3Y3XzJINmdGxidnnhZoltcXS7wrC= MV[yNVE4ODl6OB?=
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KHYG-1 NFvJN4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV6wWY5qOSEQvF2= NWS3cJp2OjRiaB?= MmraVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi NGTjWlQzOTF5MEm4PC=>
SNT-16 NWPnd3dMSXCxcITvd4l{KEG|c3H5 Mk\LNUDPxE1? NVTNdllYPiCq Mmn2TY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? MnXHNlEyPzB7OEi=
Jurkat NFXJVFhCeG:ydH;zbZMhSXO|YYm= MWKxJO69VQ>? NF;nSpA3KGh? NILGUGpKdmS3Y3XzJINmdGxiYYDvdJRwe2m| MYGyNVE4ODl6OB?=
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SNT-13 NHLKVI9CdnSrdnnyZYwhSXO|YYm= MmnRNUDPxE1? NWSyeGRsOjRiaB?= MnnyTY5lfWOnczDsfZRq[yCrbn\lZ5Rqd25ib3[gSWJX MoTwNlEyPzB7OEi=
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A375 NV60NIJESXW2b4DoZYd6KEG|c3H5 NVu3SFBDOTBibl2= MlLwNVIhcA>? MnrTTY5lfWOnczDmc5Ju[XSrb36gc4Yh[XW2b4DoZYdwe2:vZYO= MlzwNlMxPzlyOEO=
BLM MUHBeZRweGijZ4mgRZN{[Xl? NWfDdFQxOTBibl2= MWKxNkBp Mo\NTY5lfWOnczDmc5Ju[XSrb36gc4Yh[XW2b4DoZYdwe2:vZYO= M1m5VFI{ODd7MEiz
H1299 M1rNdGFxd3C2b4Ppd{BCe3OjeR?= MmnpPFAhdk1? MVKyOEBp NEX1XIlFVVOR MXTT[Y5{cXSrenXzJG5US0yFIHPlcIx{KHSxIF3TR{1l\XKrdnXkJIlEQS2rbnT1Z4VlKGGyb4D0c5Nqew>? MVKyOVMzOzZ7Mx?=
Hut-78 M3zLc2Z2dmO2aX;uJGF{e2G7 MYexNFAhdk1? M4Cy[VI1KGh? NHPsWXVFVVOR M1vHRWRwf26{ZXf1cIF1\XNiVFfGMe6zOSCjbnSgTWwuOTBiZYjwdoV{e2mxbh?= NXm5bZJWOjV4OEGzN|U>
H9 M4exSWZ2dmO2aX;uJGF{e2G7 M4PScFExOCCwTR?= M1zPUlI1KGh? MXvEUXNQ NVfqXFlyTG:5boLl[5Vt[XSnczDUS2Yu|rJzIHHu[EBKVC1zMTDlfJBz\XO|aX;u NHzUVWwzPTZ6MUOzOS=>
HH NVm3bVN{TnWwY4Tpc44hSXO|YYm= NHPMbm4yODBibl2= Mm\VNlQhcA>? NIHGNYJFVVOR MofL[I94dnKnZ4XsZZRmeyCWR1[t{tIyKGGwZDDJUE0yOiCneIDy[ZN{cW:w MYWyOVY5OTN|NR?=
Hut-78 MWfNbYdz[XSrb36gRZN{[Xl? MVOxNFAhdk1? NFL0[FEzPCCq MonKSG1UVw>? NFrJdFFT\WS3Y3XzJINmdGxibXnndoF1cW:wIHL5JFgx6oDVOUCl NFnW[5UzPTZ6MUOzOS=>
HH NEjHZ2tOcWe{YYTpc44hSXO|YYm= NYi0U2xlOTByIH7N NYTINY1IOjRiaB?= NFzlfoRFVVOR M2GxW3Jm\HWlZYOgZ4VtdCCvaXfyZZRqd25iYomgPFDjiJN7MTW= M4T1[VI2PjhzM{O1
U937 MX3GeY5kfGmxbjDBd5NigQ>? Mn[xNVAxKG6P MYS2JIg> M3nIOmlv\HWlZYOgTWwuQCCneIDy[ZN{cW:wIHnuJGxRWy2|dHnteYxifGWmIGW5N|chdWGlcn;wbIFo\XN? NEfJboszPTd7MUS3Oy=>
human PBMC NFXkSXNHfW6ldHnvckBCe3OjeR?= MmLhNVAxKG6P MlLzNlQhcA>? NYOzSot7UW6mdXPld{BKVC16IILlcIVie2V? MXuyOVc6OTR5Nx?=
ES6 NWLQbYlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMECyNUBvVQ>? NWX3XWpSW0GQR1XS
SK-UT-1 MlvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMU[zJI5O MmTVV2FPT0WU
SH-4 NFP5doZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMUezJI5O MVrTRW5ITVJ?
TE-9 NX\KTm45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\kOlY2UUN3ME2wMlE5OiCwTR?= NUHXO2Y6W0GQR1XS
A253 NVv5dpkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPOdnkzUUN3ME2wMlIxQCCwTR?= MVTTRW5ITVJ?
no-10 NULnTodiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jXXmlEPTB;MD6yNUBvVQ>? M{nq[XNCVkeHUh?=
MMAC-SF NXK1XndPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2O1[2lEPTB;MD6yNVYhdk1? NWrFNoZ2W0GQR1XS
A101D MmTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfS[3JKSzVyPUCuNlI2KG6P Moq2V2FPT0WU
NTERA-S-cl-D1 MoHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjOOXJKSzVyPUCuNlQ{KG6P MnKxV2FPT0WU
8-MG-BA Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvjPJpZUUN3ME2wMlI2KG6P M2H2O3NCVkeHUh?=
KNS-42 NEHOcHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMkW4JI5O MVLTRW5ITVJ?
LXF-289 MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj2eoxKSzVyPUCuNlY6KG6P M1[3WnNCVkeHUh?=
OVCAR-4 NH\3T25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMki5JI5O NFG5W5VUSU6JRWK=
LOUCY MkGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPtVXVKSzVyPUCuNlk{KG6P M2XibnNCVkeHUh?=
BB65-RCC NHzVd2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO5[odNUUN3ME2wMlMxPCCwTR?= NGXIZ2xUSU6JRWK=
D-542MG NHzU[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrLbXZKSzVyPUCuN|I6KG6P MUPTRW5ITVJ?
ONS-76 NVz1V3FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TEV2lEPTB;MD6zN{BvVQ>? M4j1[3NCVkeHUh?=
BB30-HNC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33XcmlEPTB;MD6zN|Uhdk1? MV\TRW5ITVJ?
KS-1 NILJPZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HXc2lEPTB;MD6zOEBvVQ>? M1jLfnNCVkeHUh?=
A388 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmwSIs6UUN3ME2wMlM2PiCwTR?= MYXTRW5ITVJ?
ES8 M{fGSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu4TWM2OD1yLkSgcm0> NW\p[ngxW0GQR1XS
MZ2-MEL M4XJ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzJSVBKSzVyPUCuOFA4KG6P Mk\GV2FPT0WU
HCC2998 NF7wO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYroUWVWUUN3ME2wMlQyOiCwTR?= NV3tW2tPW0GQR1XS
D-247MG NHrTUIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC5[lZKSzVyPUCuOFE{KG6P NITjfZVUSU6JRWK=
ACN MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFftfYFKSzVyPUCuOFE4KG6P M4DxWHNCVkeHUh?=
LB2518-MEL MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqzTWM2OD1yLkSyOUBvVQ>? MofjV2FPT0WU
ES1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwNEOgcm0> MmnXV2FPT0WU
HCE-T MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwNEO5JI5O NX;ifIVjW0GQR1XS
OS-RC-2 NFnm[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLiTWM2OD1yLkS0JI5O NH7mTlhUSU6JRWK=
MFH-ino NFyyNlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fhWmlEPTB;MD60OFMhdk1? MVzTRW5ITVJ?
OCUB-M M1K3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjkS3FkUUN3ME2wMlQ1PyCwTR?= NEX4O2tUSU6JRWK=
CP66-MEL NHfCXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDPTWM2OD1yLkS3N{BvVQ>? M3fRPXNCVkeHUh?=
LB771-HNC NFrhdYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XXOmlEPTB;MD60O|Qhdk1? MXvTRW5ITVJ?
DSH1 NIqyTW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PNcGlEPTB;MD60PEBvVQ>? NVPXe4VZW0GQR1XS
HUTU-80 NE\sW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7PbXFGUUN3ME2wMlU{OyCwTR?= NGC0NJhUSU6JRWK=
CESS MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TMSmlEPTB;MD61N|ghdk1? MV\TRW5ITVJ?
NCI-H747 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm3TWM2OD1yLkWzPUBvVQ>? NHnnTI9USU6JRWK=
HT-144 M1qwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DpT2lEPTB;MD61O|Yhdk1? MX\TRW5ITVJ?
COLO-829 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;WblhKSzVyPUCuOlE1KG6P M1PuUHNCVkeHUh?=
A4-Fuk NX30Zo9[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPDUGtKSzVyPUCuOlI{KG6P MXnTRW5ITVJ?
GI-ME-N M4nDOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS5VYlKSzVyPUCuOlM1KG6P MYHTRW5ITVJ?
LB831-BLC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP5TWM2OD1yLk[0NUBvVQ>? MX;TRW5ITVJ?
HOP-62 NGSweI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW5Wm9KSzVyPUCuOlQ4KG6P M1za[XNCVkeHUh?=
BB49-HNC NEP0ZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q0e2lEPTB;MD62OVIhdk1? MnrNV2FPT0WU
D-336MG NIW5bVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwNkW3JI5O MlXjV2FPT0WU
TK10 NVjh[21jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjl[XNUUUN3ME2wMlY4QSCwTR?= M1nNO3NCVkeHUh?=
Ramos-2G6-4C10 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwNkmzJI5O MnTQV2FPT0WU
LB373-MEL-D Mn:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVflfppXUUN3ME2wMlchdk1? NF74[VlUSU6JRWK=
SF126 M{XwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3OTWM2OD1yLkewNUBvVQ>? NE\DTmtUSU6JRWK=
UACC-257 NVryblllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwN{Ggcm0> M{jiSnNCVkeHUh?=
KINGS-1 NF7scZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXZTWM2OD1yLkeyNkBvVQ>? NYTy[GhPW0GQR1XS
LS-513 MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljpTWM2OD1yLkezPUBvVQ>? NHPVVYRUSU6JRWK=
GI-1 NH71UWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHTTWM2OD1yLke2OEBvVQ>? M{LCTHNCVkeHUh?=
ES7 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLoTWM2OD1yLke2OkBvVQ>? MUTTRW5ITVJ?
LB2241-RCC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnO5TWM2OD1yLkiwOEBvVQ>? MlS1V2FPT0WU
D-263MG NW\ET2NJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\tXpBnUUN3ME2wMlgxPyCwTR?= NG\BeWVUSU6JRWK=
SW684 NELzN|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLlTXZpUUN3ME2wMlgzOSCwTR?= NEmzUVJUSU6JRWK=
ML-2 M2rPXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3UTWM2OD1yLkiyNUBvVQ>? NXWwOmpRW0GQR1XS
SK-LMS-1 NFHIb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\ZSHVKSzVyPUCuPFU1KG6P MnPvV2FPT0WU
TE-5 NFvBbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W4XWlEPTB;MD64OlUhdk1? NGXZPFVUSU6JRWK=
QIMR-WIL NX\4Um1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTVTWM2OD1yLki4PUBvVQ>? NILPR|FUSU6JRWK=
NCI-H1355 NWj4fnRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwOEm1JI5O NVLw[ndVW0GQR1XS
SNB75 NEW0dlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD2TWM2OD1yLkmxNkBvVQ>? NXTiOnM{W0GQR1XS
RXF393 NVH2cXdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHHfm5SUUN3ME2wMlkyPCCwTR?= NUjscmZHW0GQR1XS
IST-MEL1 M3\HcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml36TWM2OD1yLkmxO{BvVQ>? MnfXV2FPT0WU
SF268 MlLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnxTWM2OD1yLkmyN{BvVQ>? MVrTRW5ITVJ?
KALS-1 NF;EdVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwOUK1JI5O NFLqco1USU6JRWK=
HC-1 NGOwUI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TmOmlEPTB;MD65O|Uhdk1? NFPvWo9USU6JRWK=
SW872 NH;wdI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwOUm2JI5O MXjTRW5ITVJ?
PSN1 NHXsVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW0TWM2OD1zLkCxJI5O NGrYWlJUSU6JRWK=
TE-1 NHjHdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGq0fFJKSzVyPUGuNFMhdk1? NFTNXFdUSU6JRWK=
TE-10 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\0TGlEPTB;MT6wN{BvVQ>? M3HHVHNCVkeHUh?=
RKO MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTFwME[gcm0> NVr6WplFW0GQR1XS
LC-2-ad MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHVWGdKSzVyPUGuNFghdk1? M33PfXNCVkeHUh?=
SK-MM-2 NWS2epRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILWOmtKSzVyPUGuNFkhdk1? NF7Hc2pUSU6JRWK=
VA-ES-BJ NVLCbIozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Hlc2lEPTB;MT6wPUBvVQ>? Mn\VV2FPT0WU
MZ7-mel NETOcIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;XTWM2OD1zLkC5JI5O NV3TOnROW0GQR1XS
D-392MG M17aXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe5OZlKSzVyPUGuNUBvVQ>? M3n1WXNCVkeHUh?=
CCRF-CEM M4[xT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HB[mlEPTB;MT6xN{BvVQ>? NVvJcHdbW0GQR1XS
EM-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH63bnFKSzVyPUGuNVYhdk1? NX25NJZ{W0GQR1XS
HAL-01 M{e2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV76O5FSUUN3ME2xMlE5KG6P NIDZdFJUSU6JRWK=
TE-8 M{\VWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzhclFPUUN3ME2xMlE6KG6P MUjTRW5ITVJ?
NCI-H1882 NXXPcnJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLVe4FMUUN3ME2xMlIhdk1? MWHTRW5ITVJ?
Daudi NH7TSY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn4NHJRUUN3ME2xMlIzKG6P Mn;HV2FPT0WU
BL-41 M{DBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PHOWlEPTB;MT6yOUBvVQ>? MULTRW5ITVJ?
SR MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfLfGZKSzVyPUGuNlUhdk1? Mny1V2FPT0WU
KM12 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zEZ2lEPTB;MT6yO{BvVQ>? NHfLfY9USU6JRWK=
K5 NEXkbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTFwMkigcm0> M1LwNnNCVkeHUh?=
A3-KAW M3rRcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHITWM2OD1zLkK4JI5O NWnyZ3BxW0GQR1XS
CMK M4K2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXZTWM2OD1zLkK5JI5O NU\jVFVXW0GQR1XS
Calu-6 MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Hqb2lEPTB;MT6yPUBvVQ>? MlL0V2FPT0WU
IST-SL2 NGHmfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjuSYtKSzVyPUGuN|Ehdk1? NIjsbXBUSU6JRWK=
OPM-2 NHvOcplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M32yU2lEPTB;MT6zN{BvVQ>? NW\URWFKW0GQR1XS
DU-4475 Mk\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVOwXlFZUUN3ME2xMlM3KG6P MWnTRW5ITVJ?
ECC12 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXiTWM2OD1zLkO3JI5O NGXteWNUSU6JRWK=
L-540 NF3yVpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fYW2lEPTB;MT6zO{BvVQ>? M{nRfnNCVkeHUh?=
CAS-1 NWLKTnZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3uyeGlEPTB;MT6zO{BvVQ>? M2ji[XNCVkeHUh?=
PF-382 NYDhPGJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzBTWM2OD1zLkS3JI5O NVfnWmx1W0GQR1XS
LS-411N NIjLPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGSz[XFKSzVyPUGuOVMhdk1? MXTTRW5ITVJ?
NCI-H69 NUPFW5RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnzVmNSUUN3ME2xMlU1KG6P MUDTRW5ITVJ?
NB12 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jLRmlEPTB;MT61OkBvVQ>? MmrTV2FPT0WU
HEL M4niZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q5XWlEPTB;MT62NUBvVQ>? NVXaVpRPW0GQR1XS
GCIY NFLaXZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LZVmlEPTB;MT62NkBvVQ>? Mmj0V2FPT0WU
EHEB NWLufFZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;Yd4pKSzVyPUGuOlchdk1? MmDyV2FPT0WU
TGBC1TKB NV7UTHk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLzVJdKSzVyPUGuO|Ehdk1? M33Xd3NCVkeHUh?=
KURAMOCHI MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDsTWM2OD1zLkeyJI5O M4i5e3NCVkeHUh?=
U-266 NXTkVVR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[zSGlEPTB;MT63OkBvVQ>? MnvWV2FPT0WU
LC4-1 NED6WWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\XTWM2OD1zLke5JI5O MlvkV2FPT0WU
NCI-H2126 M1O2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTFwODDuUS=> MnrYV2FPT0WU
NCI-H1092 M4G1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTFwODDuUS=> M1\ORnNCVkeHUh?=
GB-1 NYLISVVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPJT3lKSzVyPUGuPFEhdk1? NIHqeYNUSU6JRWK=
MV-4-11 M3vDfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFwOEKgcm0> NGroTIhUSU6JRWK=
Becker MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTFwOEOgcm0> NFzZcpFUSU6JRWK=
MPP-89 NVXSS|VtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi0bldKSzVyPUGuPFkhdk1? MWDTRW5ITVJ?
BE-13 MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PZeGlEPTB;MT65N{BvVQ>? NWDGN2tyW0GQR1XS
697 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjiZ4NKSzVyPUGuPVkhdk1? NV;QWphwW0GQR1XS
NKM-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn3TWM2OD1{IH7N Mlq0V2FPT0WU
NB13 M2TDU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nQV2lEPTB;MjDuUS=> NUjCdmc1W0GQR1XS
LS-123 M1m1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7xdGNyUUN3ME2yMlAzKG6P MnTRV2FPT0WU
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NB5 M3vvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;DXmdOUUN3ME2yMlI4KG6P NW\KV|loW0GQR1XS
BC-1 MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXLZ|BKSzVyPUKuN|Ehdk1? Mon4V2FPT0WU
NB10 M{TEc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LDN2lEPTB;Mj6zNkBvVQ>? M3zRbnNCVkeHUh?=
RPMI-8226 MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjFeZFUUUN3ME2yMlM2KG6P M{HnUHNCVkeHUh?=
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NCI-H748 NIfVTllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\jR5prUUN3ME2yMlM6KG6P NYTYOIN1W0GQR1XS
KU812 Ml\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;Yc21KSzVyPUKuOFIhdk1? MkPVV2FPT0WU
NCI-H64 NIH0bXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzFN49RUUN3ME2yMlQ1KG6P NVS5V|g6W0GQR1XS
NB69 NHrF[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr2e3gzUUN3ME2yMlQ3KG6P MYPTRW5ITVJ?
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LB1047-RCC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LlOGlEPTB;Mj61O{BvVQ>? NYf5eJJLW0GQR1XS
EB-3 NXnQUXJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPYcXBKSzVyPUKuOlYhdk1? M{CzTXNCVkeHUh?=
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EW-16 MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TpVWlEPTB;Mj63OUBvVQ>? MUTTRW5ITVJ?
CTV-1 NGnwdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7OTWM2OD1{Lkigcm0> NGrGW4pUSU6JRWK=
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NEC8 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIexSVdKSzVyPUOuN|Uhdk1? MULTRW5ITVJ?
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DB NX7IeW1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTNwNEGgcm0> MmDSV2FPT0WU
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RPMI-8402 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXoUXAzUUN3ME2zMlUhdk1? NH3Y[ZZUSU6JRWK=
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EVSA-T NVjLW5ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTPcXRlUUN3ME2zMlYhdk1? Mn7zV2FPT0WU
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LC-1F Mnm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorLTWM2OD1|Lke0JI5O NYnzZpFoW0GQR1XS
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HD-MY-Z MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfnTWM2OD1|LkmzJI5O MnG2V2FPT0WU
NCI-H2141 M4nD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\ofmlEPTB;ND6wOUBvVQ>? NWLCdFliW0GQR1XS
K-562 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGm2WnZKSzVyPUSuNVIhdk1? NInjW4pUSU6JRWK=
NCI-H1648 NUTyWpd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmniTWM2OD12LkGzJI5O NH\ibndUSU6JRWK=
OMC-1 NXjvXGhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfkfHFKSzVyPUSuNVghdk1? MYXTRW5ITVJ?
LB647-SCLC NF35U25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkewTWM2OD12LkKyJI5O MmLYV2FPT0WU
TE-12 M3HhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3pTWM2OD12LkK1JI5O M3LMcHNCVkeHUh?=
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Raji MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33iVWlEPTB;ND60OkBvVQ>? MYrTRW5ITVJ?
NALM-6 MorSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\xfGlEPTB;ND60PUBvVQ>? NGfWcoFUSU6JRWK=
HL-60 NFXHfFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;EV21KSzVyPUSuOlchdk1? M33NPXNCVkeHUh?=
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MHH-PREB-1 NV2yV3VIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTRwOE[gcm0> MVLTRW5ITVJ?
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JiyoyeP-2003 MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXwTWM2OD13IH7N Ml\ZV2FPT0WU
SBC-1 MmXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXQfZRKSzVyPUWuNFEhdk1? MYnTRW5ITVJ?
CHP-126 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17XcWlEPTB;NT6wOkBvVQ>? NYrtZ|BKW0GQR1XS
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SW962 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;kNXdKSzVyPUWuNlEhdk1? MVXTRW5ITVJ?
EW-1 MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn3PGU2UUN3ME21MlMyKG6P MVLTRW5ITVJ?
NCI-H1417 MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7WTWM2OD13LkWxJI5O MofZV2FPT0WU
LU-65 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\lc2lEPTB;NT64OEBvVQ>? NUnXdmJmW0GQR1XS
D-502MG NEP6N2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUiwTmZIUUN3ME22MlM4KG6P NEPTUlRUSU6JRWK=
BC-3 M1HnZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULvWY1vUUN3ME22MlYyKG6P MkjaV2FPT0WU
GDM-1 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jpVmlEPTB;Nj63O{BvVQ>? M4\Rc3NCVkeHUh?=
NCI-H2196 M4ntXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DsXmlEPTB;Nj64JI5O NVfoW2NRW0GQR1XS
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JVM-2 NF23UHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nTbmlEPTB;Nz6yPEBvVQ>? MkTNV2FPT0WU
LU-134-A MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTdwM{mgcm0> NIX6[nZUSU6JRWK=
NCI-H1694 NUPjO5o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzNbIZKSzVyPUeuOVghdk1? MV;TRW5ITVJ?
NCI-SNU-16 MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTdwNkWgcm0> NHvke5VUSU6JRWK=
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NB6 NF2ydWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2GzcWlEPTB;OD60PEBvVQ>? M4\DXHNCVkeHUh?=
MLMA NVr4d2dkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nqS2lEPTB;OD64OUBvVQ>? NH3WTHFUSU6JRWK=
ATN-1 M2f3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRThwOEmgcm0> NHPXOINUSU6JRWK=
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DMS-114 NFnzOVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\oUmlEPTB;OT62NkBvVQ>? MmTJV2FPT0WU
CTB-1 NHu4WlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHpR45KSzVyPUmuOlchdk1? NYXrSI1tW0GQR1XS
NCI-H2081 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLpepNKSzVyPUGwMlA6KG6P MmjwV2FPT0WU
ES5 NFjWRpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTFyLkO4JI5O MnLBV2FPT0WU
HCC1599 M1vDdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4noXWlEPTB;MUGuPVEhdk1? NWjMXZVJW0GQR1XS
NCI-H23 M1LRNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF{LkGyJI5O NY\6UWVJW0GQR1XS
NCI-H1581 M33tOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nIR2lEPTB;MUKuNlghdk1? NVL1cmg2W0GQR1XS
JVM-3 NX2xOJh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzBVZRKSzVyPUGyMlk6KG6P Mn3LV2FPT0WU
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JAR Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DzT2lEPTB;MU[uNVMhdk1? M3LCfHNCVkeHUh?=
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U-87-MG MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fSTWlEPTB;MU[uO|Yhdk1? MXHTRW5ITVJ?
NCI-H1436 M2LM[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHoW3JKSzVyPUG3MlAyKG6P NYfwTXAxW0GQR1XS
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COLO-800 M1rwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\qSVRKSzVyPUG3MlY1KG6P MX;TRW5ITVJ?
MFM-223 MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL2TWM2OD1zNz65NUBvVQ>? MV7TRW5ITVJ?
EW-18 NYjMb3M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWL0UYpLUUN3ME2xO{46PiCwTR?= NH3qeI9USU6JRWK=
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EoL-1- MlzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTF6LkOxJI5O NUHJRZpJW0GQR1XS
NCCIT MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;0SllKSzVyPUG4MlM3KG6P M1XabnNCVkeHUh?=
DG-75 NHTJXIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF23VW1KSzVyPUG4MlYyKG6P NY\uPFR6W0GQR1XS
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... Click to View More Cell Line Experimental Data

In vivo試験 The anticancer effects of bortezomib as a single agent have been demonstrated in xenograft models of multiple myeloma, adult T-cell leukemia, lung, breast, prostate, pancreatic, head and neck, and colon cancer, and in melanoma. [2] Oral bortezomib 1.0 mg/ kg daily for 18 days causes tumor growth delays, as well as a decrease in the number of metastases in the Lewis lung cancer model. Bortezomib at a single dose of up to 5 mg/kg significantly decreased the surviving fraction of breast tumor cells. Bortezomib 1.0 mg/kg administrated weekly for 4 weeks reduces tumor growth by 60% in murine xenograft models of prostate cancer. 1.0 mg/kg Bortezomib administration for 4 weeks results in a 72% or 84% reduction in pancreatic cancer murine xenografts growth, as well as an increase in tumor cell apoptosis. 1.0 mg/kg Bortezomib treatment results in significant inhibition of human plasmacytoma xenograft growth, increase in tumor cells apoptosis and overall survival, and a decrease in tumor angiogenesis. [3]
臨床試験 A phase I study of weekly subcutaneous Bortezomib in patients with steroid-refractory or -dependent chronic graft versus host disease is currently in recruiting.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[4]

Kinetic Methods In a typical kinetic run, 2.00 mL of assay buffer (20 mM HEPES, 0.5 mM EDTA, 0.035% SDS, pH 7.8) and Suc-Leu-Leu-Val-Tyr-AMC in DMSO are added to a 3 mL fluorescence cuvette, and the cuvette is placed in the jacketed cell holder of a fluorescence spectrophotometer. Reaction temperature is maintained at 37℃ by a circulating water bath. After the reaction solution has reached thermal equilibrium (5 minutes), 1 μL−10 μL of the stock enzyme solution is added to the cuvette. Reaction progress is monitored by the increase in fluorescence emission at 440 nm (λex= 380 nm) that accompanies cleavage of AMC from peptide-AMC substrates.

細胞アッセイ:

[5]

細胞株 Human multiple myeloma cells line U266
濃度 ~10 μM
反応時間 2 days
実験の流れ

The inhibitory effect of Bortezomib on cell growth is assessed by measuring MTT dye absorbance of the cells. Cells from 48-hour cultures are pulsed with 10 μL of 5 mg/mL MTT to each well for the last 4 hour of 48-hour cultures, followed by 100 μL of isopropanol containing 0.04 N HCl. Absorbance is measured at 570 nm using a spectrophotometer.

動物実験:

[3]

動物モデル Human plasmacytoma xenografts RPMI 8226
製剤 Saline
投薬量 1 mg/kg
投与方法 i.v. twice weekly for 4 weeks, then once weekly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Bortezomib (PS-341) SDF
分子量 384.24
化学式

C19H25BN4O4

CAS No. 179324-69-7
保管 3年-20℃
2年-80℃in solvent
別名 LDP-341, MLM341
溶解度 (25°C) * In vitro DMSO 76 mg/mL (197.79 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 B-​[(1R)​-​3-​methyl-​1-​[[(2S)​-​1-​oxo-​3-​phenyl-​2-​[(2-​pyrazinylcarbonyl)​amino]​propyl]​amino]​butyl]​-boronic acid

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Frequently Asked Questions

  • Question 1
    On your website, it is mentioned that Bortezomib should be prepared at a concentration of 5 mg/ml in 2% DMSO/30% PEG300/ddH2O for in vivo use. But on the product sheet we received with the compound, it is mentioned: 5mg/ml in 0.5% methylcellulose, 0.2% tween 80. So which is the correct preparation buffer?

    Answer: S1013 Bortezomib in 2% DMSO+30% PEG 300+ddH2O at 5 mg/ml is a clear solution, and it in 0.5% methylcellulose+0.2% Tween 80 is a suspension. Please choose the suitable vehicle according to your administration route. When you prepare the clear solution, please dissolve Bortezomib in DMSO first, make sure it dissolves well, warm it up to 45 degree and/or sonicate if necessary, then add PEG, mix well, and finally add water.

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Tags: Bortezomib (PS-341)を買う | Bortezomib (PS-341)供給者 | Bortezomib (PS-341)を購入する | Bortezomib (PS-341)費用 | Bortezomib (PS-341)生産者 | オーダーBortezomib (PS-341) | Bortezomib (PS-341)代理店
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