Bortezomib (PS-341) 化学構造
分子量: 384.24

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MSDS

製品説明

  • Compare Proteasome Inhibitors
    Proteasome製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Bortezomib (PS-341)は、強力なプロテアソーム阻害剤で、Kiが0.6nMです。
ターゲット

20S proteasome

IC50

0.6 nM (Ki) [1]

In vitro試験 Bortezomib, a boronic acid dipeptide, is a highly selective, reversible inhibitor of the 26S proteasome which primarily functions in the degradation of mis-folded proteins and is essential for the regulation of the cell cycle. Exposure to Bortezomib has been shown to stabilize p21, p27, and p53, as well as the proapoptotic Bid and Bax proteins, caveolin-1, and inhibitor κB-α, which prevents activation of nuclear factor κB-induced cell survival pathways. Bortezomib also promotes the activation of the proapoptotic c-Jun-NH2 terminal kinase, as well as the endoplasmic reticulum stress response. Alteration of the levels of these cellular proteins leads to inhibition of proliferation, migration, and promotion of apoptosis of cancer cells. [2] Bortezomib is shown to penetrate into cells and inhibit proteasome-mediated intracellular proteolysis of long-lived proteins with a concentration that inhibits 50% of the proteolysis of ∼0.1 μM. The average growth inhibition of 50% value for Bortezomib across the entire panel of 60 cancer cell lines derived from multiple human tumors from the US National Cancer Institute (NCI) is 7 nM. Treatment of PC-3 cells with Bortezomib (100 nM) for 8 h results in the accumulation of cells in G2-M, with a corresponding decrease in the number of cells in G1. Bortezomib kills PC-3 cells at 24 and 48 hr with IC50 of 100 and 20 nM, respectively. Bortezomib induces nuclear condensation at 16–24 hr after treatment. Bortezomib treatment leads to PARP cleavage in a time-dependent manner with concentrations as low as 100 nM being effective at 24 hr. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
MCF-7 NGXlPG1EgXSxdH;4bYMhSXO|YYm= NGrIPWU2OCEQvF2= M1PPWlQ5KGh? NGj5eopFVVOR NUKwSZM{U2mubIOgZ4VtdHNiYomgcY9z\SC2aHHuJFk6LQ>? NVex[3F[OTB2OUm2OFM>
OVCA 429 MYDGeY5kfGmxbjDBd5NigQ>? MnnUN|AxKG6P NFXPbmc1QCCq M{Hu[GROW09? NV\L[ZhvTGm|coXweJMhcW62YXP0JI12dHSrY3XscJVt[XJidIXtc5Ihe3CqZYLvbYR{ NGO0d2kyODl7OUe2Oi=>
RPMI8226 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWqxNFAhdk1? NHu5O2I1QCCq Mn7pSG1UVw>? NEnKZ|VKSzVyPUOwJI5O MW[xNVMxPjR6OR?=
Dox40 NH;WUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULsW|NJOTByIH7N NV7qTIVnPDhiaB?= NYH1cnV[TE2VTx?= M{THZmlEPTB;NECgcm0> NYfPSlJKOTF|ME[0PFk>
MR20 M1;Yc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j4cFExOCCwTR?= M2PkWFQ5KGh? M{fj[2ROW09? MUHJR|UxRTJyIH7N Mln4NVE{ODZ2OEm=
LR5 M{ntb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLzNVAxKG6P MYe0PEBp MV7EUXNQ NFv5SZVKSzVyPUKwJI5O M4fmWFEyOzB4NEi5
U266 M3HVcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzodVAyODBibl2= NYHhN3E{PDhiaB?= M2LwOGROW09? M4iwTGlEPTB;MzDuUS=> MnvsNVE{ODZ2OEm=
IM-9 MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXYWmlrOTByIH7N MUK0PEBp M4OxSGROW09? M1;5PGlEPTB;NjDuUS=> NGXtSWYyOTNyNkS4PS=>
Hs Sultan MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[xNFAhdk1? NXzQb2N5PDhiaB?= Mn;HSG1UVw>? MmW2TWM2OD1{MDDuUS=> MkfyNVE{ODZ2OEm=
PAM-LY2 MorUSpVv[3Srb36gRZN{[Xl? MUexNFAhdk1? M2nDTlEzKGh? MoHuSG1UVw>? M2[yZmlvcGmkaYTzJG5HNc78QjDhZ5RqfmG2aX;u MkHjNVE{PTB7MUO=
PAM 212 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zje|ExOCCwTR?= NX\h[ZFXPzJiaB?= M{n5WmROW09? NXGx[Yk3UW6qaXLpeJMh[2WubDD2bYFjcWyrdIm= NVj1d5lxOTF|NUC5NVM>
PAM-LY2 NHridIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OxdlExOCCwTR?= MofLO|IhcA>? MWPEUXNQ M4DibGlvcGmkaYTzJINmdGxidnnhZoltcXS7 MXGxNVM2ODlzMx?=
B4B8 NITsPW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTKNVAxKG6P NFnvPZM4OiCq MYHEUXNQ M4nUcGlvcGmkaYTzJINmdGxidnnhZoltcXS7 NYqxVpBNOTF|NUC5NVM>
B7E3 NILBV2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\LWXhpOTByIH7N MUC3NkBp NIrjSZRFVVOR M{O0V2lvcGmkaYTzJINmdGxidnnhZoltcXS7 M3PpZ|EyOzVyOUGz
UM-SCC-9 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfFS5I2OTByIH7N Mof0O|IhcA>? MWHEUXNQ MWLJcohq[mm2czDj[YxtKH[rYXLpcIl1gQ>? M1PPOFEyOzVyOUGz
UM-SCC-11B NGqybndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWqxNFAhdk1? MmfrO|IhcA>? M3rKd2ROW09? MlrhTY5pcWKrdIOgZ4VtdCC4aXHibYxqfHl? MkG4NVE{PTB7MUO=
H460 M1HyV2Z2dmO2aX;uJGF{e2G7 NUHBNZZIOTBizszN NVvMeHR2OjRiaB?= NYDQPWFmTE2VTx?= M2nIdmlv\HWlZYOgRoNtNTJicHjvd5Bpd3K7bHH0bY9vKGGwZDDjcIVifmGpZTDjc5Jz\WyjdHXkJJdqfGhiR{KtUUBxcGG|ZTDhdpJme3R? M2myeVEzPDl{MUG3
U266 M2LKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nrc|UxOCCwZz;tcC=> M2DWSVQ5KGh? MYjEUXNQ NX:4O4FRUW6qaXLpeJMh[2WubDDndo94fGh? NXzVV|RvOTJ4M{G2NVk>
ARH77 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:yV|UxOCCwZz;tcC=> MUm0PEBp NUnYN2l3TE2VTx?= NWrLUGhwUW6qaXLpeJMh[2WubDDndo94fGh? MoDDNVI3OzF4MUm=
WAD-1 M1;zUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi4bo9tPTByIH7nM41t NXPMN2Q5PDhiaB?= Mnq0SG1UVw>? MXPJcohq[mm2czDj[YxtKGe{b4f0bC=> NYKzUYdvOTJ4M{G2NVk>
U266/LR7 NI\RVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP6cGFIPTByIH7nM41t MlHhOFghcA>? NIC0Z29FVVOR MVXJcohq[mm2czDj[YxtKGe{b4f0bC=> NEnIRlQyOjZ|MU[xPS=>
U266/dox4 NV7XRo9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[1NFAhdmdxbXy= NF3k[Xk1QCCq NUm5UGJUTE2VTx?= MmP3TY5pcWKrdIOgZ4VtdCCpcn;3eIg> NUjWSFc6OTJ4M{G2NVk>
RPMI8226/LR5 Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYj3UFV5PTByIH7nM41t MoXKOFghcA>? M4P5SmROW09? Ml:xTY5pcWKrdIOgZ4VtdCCpcn;3eIg> MoTqNVI3OzF4MUm=
H460 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7NNVAh|ryP NF\xSIQ4OiCq NInVO|hFVVOR NVHjenpXUUN3ME2xNFAhdk1? NVexcmhROTJ4M{G2NlA>
H358 M2nsNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13tcFExKM7:TR?= NX;jRnFGPzJiaB?= NHzFVlJFVVOR M1vSdWlEPTB;N{Cgcm0> NUCyfHZiOTJ4M{G2NlA>
H322 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vTTVExKM7:TR?= NGjHeok4OiCq M3HTRmROW09? NVqz[IZGUUN3ME22NlAhdk1? M1LnOVEzPjNzNkKw
H460 NEDSS29HfW6ldHnvckBCe3OjeR?= NVfCVGQ5OTByIH7N MX2yOEBp M3jlXWROW09? MWrJcoR2[2W|IFeyMW0ueGijc3WgZZJz\XO2IHHu[EB1fWK3bHnuJIF{e2WvYnz5MYRqe2G|c3XtZox6 NXnWVmtXOTJ4M{G2NlA>
LNCap-Pro5 NV3VSJhQTnWwY4Tpc44hSXO|YYm= MkjCNUDPxE1? MYm0JIg> MVvEUXNQ MXvTeIFjcWyrenXzJJA2Ow>? MVuxOFYyOjV|Mh?=
T29 M37KOGFxd3C2b4Ppd{BCe3OjeR?= MVS1NEBvVQ>? NVHFcYZbPDhiaDC= NXf4TGpVTE2VTx?= M1z4emlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? M3\6NlE3Pzd6MUe5
T29Kt1 NXjuemw1SXCxcITvd4l{KEG|c3H5 NWrYbVRyPTBibl2= MoHQOFghcCB? M4f3VmROW09? NGWwe4ZKdmS3Y3XzJINmdGxiYYDvdJRwe2m| MnnhNVY4PzhzN{m=
HCT116 M134TmFxd3C2b4Ppd{BCe3OjeR?= NFnNdYs2OCCwTR?= NYPGWY4{PDhiaDC= MmPJSG1UVw>? MYnJcoR2[2W|IHPlcIwh[XCxcITvd4l{ MnXxNVY4PzhzN{m=
HKe-3 MnfXRZBweHSxc3nzJGF{e2G7 MoLNOVAhdk1? MXq0PEBpKA>? NVfqWmxYTE2VTx?= MYLJcoR2[2W|IHPlcIwh[XCxcITvd4l{ NIP5OYIyPjd5OEG3PS=>
NB-1691 MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXG1VopTOSEQvF2= MWO3NkBp NXfLN3BGUW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKHSxIEWl MmrtNVc3QDl4OES=
CHLA-255 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPqNUDPxE1? NFjESnU4OiCq NEXaWWZKdmirYnn0d{Bk\WyuIIDyc4xq\mW{YYTpc44hfG9iMjW= NF\OepIyPzZ6OU[4OC=>
SK-N-AS MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTzbHEyKM7:TR?= MlHkO|IhcA>? MU\Jcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36geI8hOTBn MWOxO|Y5QTZ6NB?=
NB-1691 MnnZSpVv[3Srb36gRZN{[Xl? NHy5THUyOCCwTR?= M4q3elI1KGh? MXfTbYdvcW[rY3HueIx6KHKnZIXj[ZMh[2WubIOgbY4hfGinIFewM2cyKHCqYYPl MUOxO|Y5QTZ6NB?=
CHLA-255 MoLqSpVv[3Srb36gRZN{[Xl? NGfBN3UyOCCwTR?= M1nkcVI1KGh? MWjNc4Rme3SueTDy[YR2[2W|IHPlcIx{KGmwIITo[UBIOC:JMTDwbIF{\Q>? NYfnNWlYOTd4OEm2PFQ>
RPMI 8226 Mn;qSpVv[3Srb36gRZN{[Xl? M4jVV|IxKG6P NYrsO|FlQCCq NGfX[XBUcWewaX\pZ4FvfGy7IHXubIFv[2W|IF7GMe67SiCjY4Tpeol1gQ>? NGHpSnAyQTR|NkC1NC=>
MM.1S NUX6U3poTnWwY4Tpc44hSXO|YYm= NYD5WlI4OjBibl2= NEPLclI5KGh? MkHDV4lodmmoaXPhcpRtgSCnbnjhcoNmeyCQRj5OvmIh[WO2aY\peJk> NXvwNHI3OTl2M{[wOVA>
U266 NVLFNFQ1TnWwY4Tpc44hSXO|YYm= NF;rUYkzOCCwTR?= MXu4JIg> NVvudVE3W2mpbnnmbYNidnSueTDlcohidmOnczDOSk3PwkJiYXP0bZZqfHl? NHTNOIIyQTR|NkC1NC=>
OPM1 MlniSpVv[3Srb36gRZN{[Xl? NXrqeWVPOjBibl2= NHnKSZA5KGh? MmL0V4lodmmoaXPhcpRtgSCnbnjhcoNmeyCQRj5OvmIh[WO2aY\peJk> MlHCNVk1OzZyNUC=
INA6 NVOwOFdbTnWwY4Tpc44hSXO|YYm= MVGyNEBvVQ>? MU[4JIg> NXfqe|RYW2mpbnnmbYNidnSueTDlcohidmOnczDOSk3PwkJiYXP0bZZqfHl? MnvyNVk1OzZyNUC=
OPM2 NYT1Z5ZYTnWwY4Tpc44hSXO|YYm= NW[zd4pGOjBibl2= MX[4JIg> NVP3cYhVW2mpbnnmbYNidnSueTDlcohidmOnczDOSk3PwkJiYXP0bZZqfHl? MmHENVk1OzZyNUC=
RPMI 8226 NXHaSZZ1TnWwY4Tpc44hSXO|YYm= NFKx[IozOCCwTR?= NXnDVVNDQCCq MkTzTY5lfWOnczDEUmEhe3mwdHjld4l{ MV[xPVQ{PjB3MB?=
BaF/3 NGHZWmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLH[IViOTByIH7N NUSxNYtsPDhiaB?= MlvrTWM2OD14LkKgcm0> MWiyNFMxPTZ7Mh?=
BaF/3-p210 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f1TFExOCCwTR?= M3yzUFQ5KGh? MWjJR|UxRTRwNzDuUS=> NEPrVmEzODNyNU[5Ni=>
TCC-S NG\YO2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrS[2dCOTByIH7N NXP5N2pnPDhiaB?= NIrw[YZKSzVyPUKuPEBvVQ>? NF\yXpEzODNyNU[5Ni=>
BaF/3 NVK3bGNNTnWwY4Tpc44hSXO|YYm= NYOzfmR6PiCwTR?= MkjWOFghcA>? NXXye4N1UW6mdXPld{BiKGe{ZXH0JGcyKGOnbHytZ5lkdGViYYLy[ZN1 M4XYZlIxOzB3Nkmy
BaF/3-p210 M1jVemZ2dmO2aX;uJGF{e2G7 M3TMUVYhdk1? MoXMOFghcA>? NXHQOmlqUW6mdXPld{BiKHOuaXfoeEBIOSClZXzsMYN6[2ynIHHydoV{fA>? Mlr1NlA{ODV4OUK=
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Raji M{XHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPZbmN7OSEQvF2= MoS5NlQhcA>? NXPWPZRPWmWmdXPld{Bk\WyuII\pZYJqdGm2edMg MofxNlEyPzB7OEi=
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LCL-2 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[xNUDPxE1? Ml\HNlQhcA>? NGnkWG9T\WS3Y3XzJINmdGxidnnhZoltcXS7wrC= MkTSNlEyPzB7OEi=
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SNT-13 NV23NG83T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInCPZYyKM7:TR?= MmD3NlQhcA>? NXHPR|dJWmWmdXPld{Bk\WyuII\pZYJqdGm2edMg M2XiZlIyOTdyOUi4
SNT-16 M{K4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWKxJO69VQ>? NX:4c3M1OjRiaB?= MV3S[YR2[2W|IHPlcIwhfmmjYnnsbZR6yqB? MofqNlEyPzB7OEi=
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SNK-6 NIPyR|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M362XVEh|ryP M1nhNVI1KGh? Mn;uVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi NWnvZmdHOjFzN{C5PFg>
KHYG-1 NIP0RmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XKSFEh|ryP NXu1c|lWOjRiaB?= M{S4ZnJm\HWlZYOgZ4VtdCC4aXHibYxqfHoEoB?= M1fLU|IyOTdyOUi4
SNT-16 MUHBdI9xfG:|aYOgRZN{[Xl? M2fPdFEh|ryP Ml3UOkBp NXjGdG5jUW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= M2LGXFIyOTdyOUi4
Jurkat MonFRZBweHSxc3nzJGF{e2G7 M4L6cFEh|ryP MonwOkBp M3rweWlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? NGLRdVczOTF5MEm4PC=>
KAI-3 NH\4PWdCeG:ydH;zbZMhSXO|YYm= NXLOOIlGOSEQvF2= Mor5OkBp NWj1flZXUW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= NULvOXJUOjFzN{C5PFg>
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A375 M2fBe2F2fG:yaHHnfUBCe3OjeR?= NHj5PYMyOCCwTR?= M1rqc|EzKGh? NHj3S3ZKdmS3Y3XzJIZwem2jdHnvckBw\iCjdYTvdIhi\2:|b33ldy=> MVuyN|A4QTB6Mx?=
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Hut-78 M4jBTmZ2dmO2aX;uJGF{e2G7 MnnoNVAxKG6P MYSyOEBp NIrwO3JFVVOR MofsSI94dnKnZ4XsZZRmeyCWR1[t{tIyKGGwZDDJUE0yOCCneIDy[ZN{cW:w NWXwXGJVOjV4OEGzN|U>
H9 MWPGeY5kfGmxbjDBd5NigQ>? NWrVOItPOTByIH7N NEjBSHIzPCCq MU\EUXNQ NH\rbGFFd3ewcnXneYxifGW|IGTHSk3PujFiYX7kJGlNNTFzIHX4dJJme3Orb36= NXrDNYd7OjV4OEGzN|U>
HH NUi3XpFOTnWwY4Tpc44hSXO|YYm= NY\JO3d2OTByIH7N M1PwPFI1KGh? MlKySG1UVw>? MUfkc5dvemWpdXzheIV{KFSJRj5OtlEh[W6mIFnMMVEzKGW6cILld5Nqd25? MXGyOVY5OTN|NR?=
Hut-78 NYPOeodjVWmpcnH0bY9vKEG|c3H5 NFvRSm8yODBibl2= Mnu2NlQhcA>? Mlf0SG1UVw>? M1;tbHJm\HWlZYOgZ4VtdCCvaXfyZZRqd25iYomgPFDjiJN7MDW= NFHJdGUzPTZ6MUOzOS=>
HH MXzNbYdz[XSrb36gRZN{[Xl? MmG3NVAxKG6P NYTheJdJOjRiaB?= MV;EUXNQ MkjaVoVlfWOnczDj[YxtKG2rZ4LheIlwdiCkeTC4NQKBmzlzJR?= NFW4UGgzPTZ6MUOzOS=>
U937 MXrGeY5kfGmxbjDBd5NigQ>? MWKxNFAhdk1? MUC2JIg> MonlTY5lfWOnczDJUE05KGW6cILld5Nqd25iaX6gUHBUNXO2aX31cIF1\WRiVUmzO{Bu[WO{b4DoZYdmew>? MlLQNlU4QTF2N{e=
human PBMC NFTScGRHfW6ldHnvckBCe3OjeR?= NXnjfZFVOTByIH7N NIrXbZAzPCCq MnSxTY5lfWOnczDJUE05KHKnbHXhd4U> MYSyOVc6OTR5Nx?=
ES6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMECyNUBvVQ>? M4LPOHNCVkeHUh?=
SK-UT-1 NWfTc3RDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLvTWM2OD1yLkG2N{BvVQ>? MXLTRW5ITVJ?
SH-4 MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2mzV2lEPTB;MD6xO|Mhdk1? NXTqV2ZjW0GQR1XS
TE-9 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfuTWM2OD1yLkG4NkBvVQ>? NVvPdVFZW0GQR1XS
A253 NGLifYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fkb2lEPTB;MD6yNFghdk1? M4jadnNCVkeHUh?=
no-10 MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoCyTWM2OD1yLkKxJI5O NFXORodUSU6JRWK=
MMAC-SF MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMkG2JI5O MYDTRW5ITVJ?
A101D NGXEWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPnO|FCUUN3ME2wMlIzPSCwTR?= NVHHdWtsW0GQR1XS
NTERA-S-cl-D1 MoPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XyfmlEPTB;MD6yOFMhdk1? Mn\rV2FPT0WU
8-MG-BA MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjmN41KSzVyPUCuNlUhdk1? M2LYV3NCVkeHUh?=
KNS-42 MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHSUnFVUUN3ME2wMlI2QCCwTR?= M2\VZnNCVkeHUh?=
LXF-289 NIHXO|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\5SW55UUN3ME2wMlI3QSCwTR?= NHv6c2NUSU6JRWK=
OVCAR-4 MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TDW2lEPTB;MD6yPFkhdk1? Mlv6V2FPT0WU
LOUCY M1K1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrWVnhtUUN3ME2wMlI6OyCwTR?= NV7BU5VHW0GQR1XS
BB65-RCC MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPnTWM2OD1yLkOwOEBvVQ>? NHHWeWJUSU6JRWK=
D-542MG NWjnZWl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX0R49KSzVyPUCuN|I6KG6P Ml70V2FPT0WU
ONS-76 MlTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XZbGlEPTB;MD6zN{BvVQ>? MUDTRW5ITVJ?
BB30-HNC MmTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwM{O1JI5O M3z0XXNCVkeHUh?=
KS-1 NWnOfIxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH0TWM2OD1yLkO0JI5O MUfTRW5ITVJ?
A388 NUPUT4FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[4UmlEPTB;MD6zOVYhdk1? M1rsXHNCVkeHUh?=
ES8 NYn0UFhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHHPWdPUUN3ME2wMlQhdk1? NH;KT4FUSU6JRWK=
MZ2-MEL NH21RXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwNEC3JI5O MlLOV2FPT0WU
HCC2998 MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwNEGyJI5O NFLDNHdUSU6JRWK=
D-247MG M1zFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zDOmlEPTB;MD60NVMhdk1? NWXtSXJOW0GQR1XS
ACN M{nJWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LzVGlEPTB;MD60NVchdk1? NH:4S5VUSU6JRWK=
LB2518-MEL NEXvOlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;lTWM2OD1yLkSyOUBvVQ>? MU\TRW5ITVJ?
ES1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS1TWM2OD1yLkSzJI5O MV3TRW5ITVJ?
HCE-T MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwNEO5JI5O M4PkcHNCVkeHUh?=
OS-RC-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne4TWM2OD1yLkS0JI5O M2f5OnNCVkeHUh?=
MFH-ino M1PCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny4TWM2OD1yLkS0N{BvVQ>? NGfTWmhUSU6JRWK=
OCUB-M NY\oTY1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwNES3JI5O NUjD[XhbW0GQR1XS
CP66-MEL Mlm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTlNnlZUUN3ME2wMlQ4OyCwTR?= M1TMUHNCVkeHUh?=
LB771-HNC M4XqVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrpWnB5UUN3ME2wMlQ4PCCwTR?= MlTLV2FPT0WU
DSH1 MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTSNlJCUUN3ME2wMlQ5KG6P NFPqT21USU6JRWK=
HUTU-80 M4jmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEG0fIJKSzVyPUCuOVM{KG6P MlrCV2FPT0WU
CESS NW\QS5N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXhUHdKSzVyPUCuOVM5KG6P NX;ZRmdxW0GQR1XS
NCI-H747 M2naOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwNUO5JI5O NVziWphiW0GQR1XS
HT-144 M3\Fe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrrTnZIUUN3ME2wMlU4PiCwTR?= NWXhOXpoW0GQR1XS
COLO-829 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLiTWM2OD1yLk[xOEBvVQ>? M1vNZXNCVkeHUh?=
A4-Fuk MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwNkKzJI5O NX3rdoRnW0GQR1XS
GI-ME-N Mn7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILyfIdKSzVyPUCuOlM1KG6P Mof3V2FPT0WU
LB831-BLC NIPZeG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m2NWlEPTB;MD62OFEhdk1? M4W2O3NCVkeHUh?=
HOP-62 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDYTWM2OD1yLk[0O{BvVQ>? M3rVfXNCVkeHUh?=
BB49-HNC NWqzOZY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:0TWM2OD1yLk[1NkBvVQ>? MWPTRW5ITVJ?
D-336MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rGT2lEPTB;MD62OVchdk1? MUDTRW5ITVJ?
TK10 NGjJfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\wTWM2OD1yLk[3PUBvVQ>? MkS3V2FPT0WU
Ramos-2G6-4C10 NU\rWpFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfZV4pKSzVyPUCuOlk{KG6P NWqyUVNxW0GQR1XS
LB373-MEL-D M3XvZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFmzRYZKSzVyPUCuO{BvVQ>? NX;yXIhKW0GQR1XS
SF126 MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHGOVBKSzVyPUCuO|AyKG6P MonyV2FPT0WU
UACC-257 NEnK[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrQSGVtUUN3ME2wMlcyKG6P MUjTRW5ITVJ?
KINGS-1 NYDTbFlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwN{KyJI5O Mn;ZV2FPT0WU
LS-513 M3X2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjHR2tRUUN3ME2wMlc{QSCwTR?= NYXMe|hRW0GQR1XS
GI-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe5[3pKSzVyPUCuO|Y1KG6P NEXWU29USU6JRWK=
ES7 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwN{[2JI5O MojkV2FPT0WU
LB2241-RCC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED2VXNKSzVyPUCuPFA1KG6P NVvk[o85W0GQR1XS
D-263MG M2LBRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\mdZh[UUN3ME2wMlgxPyCwTR?= Mn;yV2FPT0WU
SW684 Ml\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvPeplKSzVyPUCuPFIyKG6P MnTHV2FPT0WU
ML-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwOEKxJI5O NX[3N5FMW0GQR1XS
SK-LMS-1 M1mxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDD[5FIUUN3ME2wMlg2PCCwTR?= NXvncYUzW0GQR1XS
TE-5 NXO0RXFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXHOZpKSzVyPUCuPFY2KG6P NUX0d2pQW0GQR1XS
QIMR-WIL NHnRNXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELVbJRKSzVyPUCuPFg6KG6P MorVV2FPT0WU
NCI-H1355 NHfR[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13WfWlEPTB;MD64PVUhdk1? MnPjV2FPT0WU
SNB75 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjTUFJKSzVyPUCuPVEzKG6P NEHlWG1USU6JRWK=
RXF393 M1LQdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf1b2F6UUN3ME2wMlkyPCCwTR?= NX;jW3RTW0GQR1XS
IST-MEL1 NGHhbIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;GTWM2OD1yLkmxO{BvVQ>? NVzUWopTW0GQR1XS
SF268 NWjrWpU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TSRWlEPTB;MD65NlMhdk1? MX\TRW5ITVJ?
KALS-1 M1X5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmGxTWM2OD1yLkmyOUBvVQ>? NHviW5FUSU6JRWK=
HC-1 MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XxR2lEPTB;MD65O|Uhdk1? MXjTRW5ITVJ?
SW872 MlfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vPXGlEPTB;MD65PVYhdk1? MX\TRW5ITVJ?
PSN1 NEi3W2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzyWlJHUUN3ME2xMlAyKG6P M2iwO3NCVkeHUh?=
TE-1 MnL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfFTWM2OD1zLkCzJI5O M2XBU3NCVkeHUh?=
TE-10 MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{faRWlEPTB;MT6wN{BvVQ>? M2XuZnNCVkeHUh?=
RKO MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT1TWM2OD1zLkC2JI5O MknCV2FPT0WU
LC-2-ad MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrwTWM2OD1zLkC4JI5O NEm5VmZUSU6JRWK=
SK-MM-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTFwMEmgcm0> MmjZV2FPT0WU
VA-ES-BJ MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPoXFBKSzVyPUGuNFkhdk1? NWrQZW9sW0GQR1XS
MZ7-mel MnzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TQTGlEPTB;MT6wPUBvVQ>? NH7NSllUSU6JRWK=
D-392MG MmT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv1TWM2OD1zLkGgcm0> MUTTRW5ITVJ?
CCRF-CEM M3S1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTFwMUOgcm0> NXLvWY1mW0GQR1XS
EM-2 NH7EToxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvUTWM2OD1zLkG2JI5O MWDTRW5ITVJ?
HAL-01 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\QTWM2OD1zLkG4JI5O NYTKc5h2W0GQR1XS
TE-8 NIq1SmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHEUFRKSzVyPUGuNVkhdk1? MVfTRW5ITVJ?
NCI-H1882 Mo\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFwMjDuUS=> M4jBSnNCVkeHUh?=
Daudi M1PTV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFwMkKgcm0> NXTZUodJW0GQR1XS
BL-41 MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TKNmlEPTB;MT6yOUBvVQ>? NF3YflNUSU6JRWK=
SR NVTOSHRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILPPJlKSzVyPUGuNlUhdk1? M3K3THNCVkeHUh?=
KM12 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j4bWlEPTB;MT6yO{BvVQ>? MYfTRW5ITVJ?
K5 MkPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjETWM2OD1zLkK4JI5O MnXHV2FPT0WU
A3-KAW M1TqUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTFwMkigcm0> MnTNV2FPT0WU
CMK NXn1NXY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfkPXBKSzVyPUGuNlkhdk1? M37mVHNCVkeHUh?=
Calu-6 NU\4[YxMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\DTWM2OD1zLkK5JI5O NXTEOphuW0GQR1XS
IST-SL2 NWPtUFVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz5OoJKSzVyPUGuN|Ehdk1? NHLDOFhUSU6JRWK=
OPM-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XuOGlEPTB;MT6zN{BvVQ>? M3e4NnNCVkeHUh?=
DU-4475 NV3PV|ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DjPWlEPTB;MT6zOkBvVQ>? MlHyV2FPT0WU
ECC12 NXm4VGdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPxWoQ3UUN3ME2xMlM4KG6P NIS5UWNUSU6JRWK=
L-540 Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFwM{egcm0> M1vzO3NCVkeHUh?=
CAS-1 Mn\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:2TWM2OD1zLkO3JI5O NUD5O21OW0GQR1XS
PF-382 M4K2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\4TWM2OD1zLkS3JI5O NVrzd5pXW0GQR1XS
LS-411N NI\JUYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXVeXlKSzVyPUGuOVMhdk1? M3nmNHNCVkeHUh?=
NCI-H69 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYGy[YN{UUN3ME2xMlU1KG6P NVv6VWxyW0GQR1XS
NB12 NWSyPFdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fLSWlEPTB;MT61OkBvVQ>? M3LL[3NCVkeHUh?=
HEL NVf1Uo9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M365XmlEPTB;MT62NUBvVQ>? M1TUenNCVkeHUh?=
GCIY MnK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzyTWM2OD1zLk[yJI5O NVux[Yg{W0GQR1XS
EHEB Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFwNkegcm0> NGf3XohUSU6JRWK=
TGBC1TKB MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLX[IdqUUN3ME2xMlcyKG6P NUfJcm9oW0GQR1XS
KURAMOCHI Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLNTWM2OD1zLkeyJI5O Mom2V2FPT0WU
U-266 NELP[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljQTWM2OD1zLke2JI5O NF7p[YRUSU6JRWK=
LC4-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13HWmlEPTB;MT63PUBvVQ>? MmTBV2FPT0WU
NCI-H2126 MmnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTFwODDuUS=> NYrjOmZYW0GQR1XS
NCI-H1092 M3HqSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HUemlEPTB;MT64JI5O M3;GZ3NCVkeHUh?=
GB-1 NWn3fJN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjtTodKSzVyPUGuPFEhdk1? MkPvV2FPT0WU
MV-4-11 NET1NmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDtTWM2OD1zLkiyJI5O MWnTRW5ITVJ?
Becker MoTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTQTWM2OD1zLkizJI5O NYXIRmlKW0GQR1XS
MPP-89 M1q5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPkUI9KSzVyPUGuPFkhdk1? MWXTRW5ITVJ?
BE-13 NHXuVGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqyTWM2OD1zLkmzJI5O NGHJXJpUSU6JRWK=
697 M4PMNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3WTWM2OD1zLkm5JI5O M2fL[HNCVkeHUh?=
NKM-1 M4nkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XY[mlEPTB;MjDuUS=> NUjwRohMW0GQR1XS
NB13 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJibl2= M17JXnNCVkeHUh?=
LS-123 MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfkTXdKSzVyPUKuNFIhdk1? MmXtV2FPT0WU
NB17 Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L0VmlEPTB;Mj6wOEBvVQ>? MmPaV2FPT0WU
LAN-6 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LxTGlEPTB;Mj6wOUBvVQ>? NFTHeldUSU6JRWK=
EW-24 NYr5Wlk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUCwdplQUUN3ME2yMlA5KG6P Ml\nV2FPT0WU
NOS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJwMUGgcm0> MVnTRW5ITVJ?
BL-70 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwMUKgcm0> NVTnclV[W0GQR1XS
GT3TKB NX\MRXh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwMUKgcm0> MV\TRW5ITVJ?
HH MkDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrkN4xKSzVyPUKuNVMhdk1? Ml3tV2FPT0WU
KE-37 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;p[WlEPTB;Mj6xN{BvVQ>? NHjoO|JUSU6JRWK=
MOLT-4 MnnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvObnZQUUN3ME2yMlE{KG6P MWrTRW5ITVJ?
EKVX NEHkR|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvCTWM2OD1{LkG0JI5O MnH4V2FPT0WU
KGN MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTqTWM2OD1{LkG1JI5O NUXBdIJkW0GQR1XS
ES4 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jhOGlEPTB;Mj6xOkBvVQ>? NWfIVWZtW0GQR1XS
SJSA-1 M1vNRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXpUItKSzVyPUKuNlEhdk1? MVTTRW5ITVJ?
KMOE-2 M{\qR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDxR2hOUUN3ME2yMlI{KG6P M{LxXHNCVkeHUh?=
NB5 M{XxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlOzTWM2OD1{LkK3JI5O MXrTRW5ITVJ?
BC-1 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJwM{Ggcm0> NFXncmhUSU6JRWK=
NB10 NUTXRlZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJwM{Kgcm0> MkTNV2FPT0WU
RPMI-8226 NFHGO|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJwM{Wgcm0> NVLYNphOW0GQR1XS
SCC-3 NUX2SXc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTJwM{egcm0> NVrSSWxQW0GQR1XS
ARH-77 NYXtVopqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr3eYxuUUN3ME2yMlM5KG6P MlPWV2FPT0WU
NCI-H748 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHV[VNKSzVyPUKuN|khdk1? Mme5V2FPT0WU
KU812 NVPYXoo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJwNEKgcm0> NIHEbJpUSU6JRWK=
NCI-H64 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL0N4NKSzVyPUKuOFQhdk1? MmnuV2FPT0WU
NB69 NYLRSppPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT0TWM2OD1{LkS2JI5O NXi0T5BXW0GQR1XS
KNS-81-FD MlqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJwNEigcm0> MX3TRW5ITVJ?
LB1047-RCC NInKS41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HjO2lEPTB;Mj61O{BvVQ>? NXzjdVh6W0GQR1XS
EB-3 M2LtXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJwNk[gcm0> NWjkOodSW0GQR1XS
Mo-T NFjvUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DOPGlEPTB;Mj63OEBvVQ>? MmH4V2FPT0WU
EW-16 MnrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfHd3BUUUN3ME2yMlc2KG6P NULHdlhEW0GQR1XS
CTV-1 NY\4dGRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XDd2lEPTB;Mj64JI5O Mn[xV2FPT0WU
ETK-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTZPXNKSzVyPUKuPFQhdk1? MlXwV2FPT0WU
C2BBe1 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r0d2lEPTB;Mj64PUBvVQ>? MnruV2FPT0WU
MOLT-16 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:zN2lEPTB;Mj64PUBvVQ>? MWTTRW5ITVJ?
SW954 MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXnTWM2OD1{Lkmgcm0> NIr4PGtUSU6JRWK=
HT NGDhSZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrzS2hUUUN3ME2zMlAzKG6P NIHhPZlUSU6JRWK=
KARPAS-299 NY\WVVZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTNwME[gcm0> M1nZenNCVkeHUh?=
MONO-MAC-6 NIfUdmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH5cYZZUUN3ME2zMlEhdk1? NGLqcGpUSU6JRWK=
CGTH-W-1 NFLQVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvHTWM2OD1|LkGgcm0> NULPOGhKW0GQR1XS
SK-PN-DW M1T4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjFTWM2OD1|LkG0JI5O NEDmNWFUSU6JRWK=
CW-2 NF:2eZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\UNphKSzVyPUOuNlEhdk1? NUHPOYlVW0GQR1XS
SK-N-DZ M{TwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\hbmlEPTB;Mz6yOkBvVQ>? M1nRSXNCVkeHUh?=
NEC8 MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTNwM{Wgcm0> NEP2OmVUSU6JRWK=
LB996-RCC NUHEOm11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTNwNDDuUS=> NX3ybG13W0GQR1XS
DB NIHyZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTNwNEGgcm0> MUXTRW5ITVJ?
TE-15 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTNwNEOgcm0> NHjNWGFUSU6JRWK=
COR-L88 MlHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTNwNEegcm0> MXrTRW5ITVJ?
LAMA-84 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jUZ2lEPTB;Mz60PUBvVQ>? NVqxfYhGW0GQR1XS
MEG-01 NX7GcppUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HkZ2lEPTB;Mz60PUBvVQ>? MmPQV2FPT0WU
LOXIMVI MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIOxXXhKSzVyPUOuOUBvVQ>? NXvSNYhEW0GQR1XS
RPMI-8402 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HRVWlEPTB;Mz61JI5O NVLXeHFTW0GQR1XS
KARPAS-45 NXHWOnJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTNwNUSgcm0> NUXMPFI{W0GQR1XS
HCC1187 Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDwT|dKSzVyPUOuOVQhdk1? MkDQV2FPT0WU
MZ1-PC MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnZNZJUUUN3ME2zMlU1KG6P NUfHNnI5W0GQR1XS
no-11 Mly2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzr[FdZUUN3ME2zMlU2KG6P NGqwRZJUSU6JRWK=
EVSA-T NEmxN|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTNwNjDuUS=> MYXTRW5ITVJ?
DJM-1 NUHyVZVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPTTWM2OD1|Lk[zJI5O NHXadVJUSU6JRWK=
COLO-684 MnrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrRVJhKSzVyPUOuOlYhdk1? Mn6xV2FPT0WU
NMC-G1 M1PrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHmO3M4UUN3ME2zMlY5KG6P Mor4V2FPT0WU
LC-1F NWHCZ3RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXwSFQxUUN3ME2zMlc1KG6P MoO5V2FPT0WU
RL95-2 MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37QTWlEPTB;Mz63PUBvVQ>? NGPCOmdUSU6JRWK=
COLO-320-HSR MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTNwOUKgcm0> MXrTRW5ITVJ?
RCC10RGB M1Lt[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTNwOUOgcm0> NWPZfopsW0GQR1XS
HD-MY-Z M4fqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNwOUOgcm0> NFvO[2RUSU6JRWK=
NCI-H2141 NU\HSYpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjXWYFMUUN3ME20MlA2KG6P M3rBRnNCVkeHUh?=
K-562 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLRb5d{UUN3ME20MlEzKG6P M2ixOXNCVkeHUh?=
NCI-H1648 NHTTb4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PLXmlEPTB;ND6xN{BvVQ>? NUexTHlMW0GQR1XS
OMC-1 MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1H5cWlEPTB;ND6xPEBvVQ>? NE\jUHFUSU6JRWK=
LB647-SCLC MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S4Z2lEPTB;ND6yNkBvVQ>? Mn\qV2FPT0WU
TE-12 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrpTpVKSzVyPUSuNlUhdk1? Mn3PV2FPT0WU
NOMO-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHzTWM2OD12LkOzJI5O M4Da[3NCVkeHUh?=
Raji M2LLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHP5bYNKSzVyPUSuOFYhdk1? NF;VTW9USU6JRWK=
NALM-6 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG4TWM2OD12LkS5JI5O Mle1V2FPT0WU
HL-60 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrERppRUUN3ME20MlY4KG6P NHzaUpJUSU6JRWK=
IST-SL1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXqTnhvUUN3ME20MlY5KG6P NHvm[IJUSU6JRWK=
MHH-PREB-1 NEX4UmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XNeWlEPTB;ND64OkBvVQ>? M2Kz[XNCVkeHUh?=
MHH-NB-11 MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS0TWM2OD12LkmxJI5O MY\TRW5ITVJ?
JiyoyeP-2003 M{LXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVn5ZYdEUUN3ME21JI5O MkT4V2FPT0WU
SBC-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfmTWM2OD13LkCxJI5O MXvTRW5ITVJ?
CHP-126 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33WdWlEPTB;NT6wOkBvVQ>? NIGxZnNUSU6JRWK=
LU-139 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTZco5FUUN3ME21MlE{KG6P NILTWXhUSU6JRWK=
NCI-SNU-5 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTVwMUegcm0> MXzTRW5ITVJ?
SW962 NVjOR443T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e1[2lEPTB;NT6yNUBvVQ>? MVvTRW5ITVJ?
EW-1 NVfacmxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTVwM{Ggcm0> NHHGcHVUSU6JRWK=
NCI-H1417 M17x[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPuTINKSzVyPUWuOVEhdk1? MWLTRW5ITVJ?
LU-65 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTVwOESgcm0> MY\TRW5ITVJ?
D-502MG MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTZwM{egcm0> NVTuT|lPW0GQR1XS
BC-3 NUTvO2l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTZwNkGgcm0> M1G2dXNCVkeHUh?=
GDM-1 NW\lOHYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTZwN{egcm0> NHfZOFdUSU6JRWK=
NCI-H2196 NUXCdVNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHHUnE6UUN3ME22Mlghdk1? NUfkcJlQW0GQR1XS
NB1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHjdVBXUUN3ME22Mlg5KG6P MYPTRW5ITVJ?
NCI-H345 MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHqTWM2OD15LkKgcm0> M37RWnNCVkeHUh?=
SU-DHL-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL5VplKSzVyPUeuNlQhdk1? NELkS|VUSU6JRWK=
JVM-2 NHi2[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfxdZhKSzVyPUeuNlghdk1? MXPTRW5ITVJ?
LU-134-A NFvrco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITJb|JKSzVyPUeuN|khdk1? M4PrR3NCVkeHUh?=
NCI-H1694 NHSxbHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvVbohKSzVyPUeuOVghdk1? MWXTRW5ITVJ?
NCI-SNU-16 NVi5cZMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v0RWlEPTB;Nz62OUBvVQ>? NHHINYxUSU6JRWK=
L-363 M1\qV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\wdHNnUUN3ME23Mlchdk1? NIfjbHhUSU6JRWK=
KG-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vHZmlEPTB;Nz65OEBvVQ>? NUDlbGlqW0GQR1XS
MN-60 NWrrdFMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHX1NGtKSzVyPUiuNVQhdk1? NEnFeWhUSU6JRWK=
NB6 Ml7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRThwNEigcm0> NHj5bItUSU6JRWK=
MLMA MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofETWM2OD16Lki1JI5O MX\TRW5ITVJ?
ATN-1 M3TUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnmTWM2OD16Lki5JI5O M2fYXHNCVkeHUh?=
SK-NEP-1 M13YZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m2cGlEPTB;OT6wNUBvVQ>? NXW5SXZ4W0GQR1XS
DMS-114 NEHHN2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTlwNkKgcm0> M{m4PHNCVkeHUh?=
CTB-1 NWTpWXJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7tTWM2OD17Lk[3JI5O NU\lcFdsW0GQR1XS
NCI-H2081 M1XGUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmroTWM2OD1zMD6wPUBvVQ>? MnnBV2FPT0WU
ES5 M2f4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPtd|dKUUN3ME2xNE4{QCCwTR?= M1jXNXNCVkeHUh?=
HCC1599 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfZXII1UUN3ME2xNU46OSCwTR?= NGDaSZdUSU6JRWK=
NCI-H23 M4Lqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4OwS2lEPTB;MUKuNVIhdk1? MoPEV2FPT0WU
NCI-H1581 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTF{LkK4JI5O NVzHXmdTW0GQR1XS
JVM-3 M4XQfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvCTm9iUUN3ME2xNk46QSCwTR?= Ml\xV2FPT0WU
NCI-SNU-1 M3zaOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXzR|ZKSzVyPUGzMlE6KG6P MVLTRW5ITVJ?
NB7 M4HrOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLTTWM2OD1zNT65NkBvVQ>? M4PPbXNCVkeHUh?=
JAR NIr2fVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX1TWM2OD1zNj6xN{BvVQ>? NUP2XW1xW0GQR1XS
TGW M37XRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn4TWM2OD1zNj60PEBvVQ>? M1rD[nNCVkeHUh?=
U-87-MG NILCcFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nlO2lEPTB;MU[uO|Yhdk1? Mk\BV2FPT0WU
NCI-H1436 M3fEdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3kTWM2OD1zNz6wNUBvVQ>? MkTEV2FPT0WU
GOTO MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrOV|JKSzVyPUG3MlA3KG6P MVXTRW5ITVJ?
COLO-800 NH7SemJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDBWIVKSzVyPUG3MlY1KG6P NF3ofoVUSU6JRWK=
MFM-223 MkXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDSTWM2OD1zNz65NUBvVQ>? NUL1boZ1W0GQR1XS
EW-18 NHmxOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrGe4N5UUN3ME2xO{46PiCwTR?= M{G1cXNCVkeHUh?=
NB14 M3HEfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\0c3dKSzVyPUG3Mlk5KG6P MmDEV2FPT0WU
EB2 NYfDNo5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC2RlRGUUN3ME2xPE4xQCCwTR?= NXHXSoZ3W0GQR1XS
EoL-1- NVLkfnBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPD[WJwUUN3ME2xPE4{OSCwTR?= MlnHV2FPT0WU
NCCIT M1LaTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3uzWWlEPTB;MUiuN|Yhdk1? MX\TRW5ITVJ?
DG-75 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDMXXZOUUN3ME2xPE43OSCwTR?= MWDTRW5ITVJ?
HCC2218 MkDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF7LkWgcm0> M37vdXNCVkeHUh?=
TE-6 NFz2bWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy5UmVLUUN3ME2yNE4xQCCwTR?= NVe0dIl{W0GQR1XS
SF539 M4jaWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofGTWM2OD1{MD62O{BvVQ>? MnrHV2FPT0WU
NCI-H446 NGDlNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLPclBlUUN3ME2yNU4yQCCwTR?= Mm\QV2FPT0WU
IST-MES1 NWW2PZd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfhfHpKSzVyPUKyMlc4KG6P NXv0TGpEW0GQR1XS
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HCC2157 M{j5UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJ|LkGzJI5O MkTxV2FPT0WU
EW-12 Ml3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfxe5dYUUN3ME2yN{4yPyCwTR?= M1\HZnNCVkeHUh?=
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DOHH-2 NWjSWJpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJ|LkS1JI5O MkfaV2FPT0WU
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EC-GI-10 NWXWflhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJ2LkKzJI5O MoHEV2FPT0WU
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ECC4 NH35[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzsVpp6UUN3ME2yPE44QSCwTR?= Mny5V2FPT0WU
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C8166 NILnc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfBTWM2OD1|NT63JI5O MVTTRW5ITVJ?
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D-283MED MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nTSmlEPTB;M{euO|khdk1? NWTueFBpW0GQR1XS
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NCI-H2227 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTRyLkS5JI5O MX;TRW5ITVJ?
SKM-1 M{LK[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv3T3VKSzVyPUSyMlY{KG6P M{LZNHNCVkeHUh?=
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NCI-H1770 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jremlEPTB;MUCyMlQ6KG6P M2Lte3NCVkeHUh?=
SIG-M5 MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLZTWM2OD1zMEWuNFYhdk1? MYrTRW5ITVJ?
GR-ST M4LzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LD[GlEPTB;MUGzMlM1KG6P MULTRW5ITVJ?
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NCI-H1650 NGnzTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnCPVV6UUN3ME2xNVUvOjlibl2= M{fHXXNCVkeHUh?=
MHH-CALL-2 NEHFPGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTFzNT63JI5O NIjEUVhUSU6JRWK=
BV-173 MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnIV2cyUUN3ME2xNlIvPzFibl2= NETBXJZUSU6JRWK=
MC116 NHfLbWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPrTWM2OD1zNEiuPFUhdk1? M{X0VXNCVkeHUh?=
NCI-H524 NETGSohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTyPZlLUUN3ME2xOVkvOSCwTR?= NIDn[oNUSU6JRWK=
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NCI-H510A MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEn6dWtKSzVyPUG4OU4{PyCwTR?= M4[2NXNCVkeHUh?=
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NCI-H187 Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIWzTZNKSzVyPUK4O{4xQCCwTR?= NILJVGpUSU6JRWK=
NCI-H2171 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrIbGZKSzVyPUK4PE46OiCwTR?= NHfzVnNUSU6JRWK=
LNCaP-Clone-FGC NIfWTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPmT4R[UUN3ME2yPVUvOjZibl2= NUj1fm1oW0GQR1XS
NCI-H1522 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP0W5Y3UUN3ME2zNFcvODVibl2= M4jSfnNCVkeHUh?=
SCH Mn\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PicmlEPTB;M{KyMlIzKG6P MlfYV2FPT0WU
THP-1 MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvhUYZKSzVyPUOyNk43KG6P MY\TRW5ITVJ?
SNU-C1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTN4Mj6wPUBvVQ>? NH;3epVUSU6JRWK=
CA46 M3fyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\GdHVUUUN3ME2zO|MvPjNibl2= NEHMPYNUSU6JRWK=
NCI-H1963 NYHU[HlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTN6Nj6xPUBvVQ>? MWPTRW5ITVJ?
DEL NHrMbYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nuSWlEPTB;M{mxMlI4KG6P Mn;MV2FPT0WU
TUR NILQdlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTN7Nj62NUBvVQ>? NWi1W4NLW0GQR1XS
NCI-H226 M3vHNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ft[WlEPTB;NECzMlI{KG6P Mn35V2FPT0WU
COLO-668 NWn6NoMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfsTG5KSzVyPUSwN{42PyCwTR?= M1jkXnNCVkeHUh?=
CPC-N NXnMVW5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L4O2lEPTB;NECzMlc4KG6P MYfTRW5ITVJ?
NCI-H889 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\CWXpKSzVyPUS2NU46OiCwTR?= MVTTRW5ITVJ?
J-RT3-T3-5 NUXnVlBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXoOXdlUUN3ME21N|IvPTdibl2= Mnf6V2FPT0WU
MSTO-211H M1XKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTV5ND6yOkBvVQ>? NYDwPFZEW0GQR1XS
SCC-15 NFz2cHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnD[Y9KSzVyPU[2O{41PyCwTR?= M{LMU3NCVkeHUh?=
SUP-T1 M1fOSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGflTINKSzVyPU[4Ok4xPCCwTR?= M4raVHNCVkeHUh?=
DMS-153 Mn\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETTWGRKSzVyPUe0Ok45OyCwTR?= MUPTRW5ITVJ?
MS-1 NED0fHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTd3OT60NkBvVQ>? NF7UeWVUSU6JRWK=
TC-YIK MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvQWIRKSzVyPUe4NU4xOSCwTR?= NV\pVY5EW0GQR1XS
RPMI-8866 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnV[Xl7UUN3ME2xNFA3NjJ6IN88US=> MXTTRW5ITVJ?
KY821 NFnZUGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLab4d1UUN3ME2xNFM3NjB2IN88US=> NYS1T2RoW0GQR1XS
P31-FUJ MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLsNGJKSzVyPUGxNVIvPzVizszN M1vW[nNCVkeHUh?=
COLO-824 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:xTos2UUN3ME2xNlYyNjd6IN88US=> NV;oO5VOW0GQR1XS
U-698-M MnvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDLb41LUUN3ME2yNlYzNjF3IN88US=> M{nTZ3NCVkeHUh?=
TE-441-T NI[2TnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHqeHFFUUN3ME2yOVIyNjdizszN MWTTRW5ITVJ?
IMR-5 MmT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIqyVWlKSzVyPUO0NFkvPjJizszN NXfKW202W0GQR1XS
NCI-H1838 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFK5dHZKSzVyPUSxPFYvOzJizszN MlzlV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 The anticancer effects of bortezomib as a single agent have been demonstrated in xenograft models of multiple myeloma, adult T-cell leukemia, lung, breast, prostate, pancreatic, head and neck, and colon cancer, and in melanoma. [2] Oral bortezomib 1.0 mg/ kg daily for 18 days causes tumor growth delays, as well as a decrease in the number of metastases in the Lewis lung cancer model. Bortezomib at a single dose of up to 5 mg/kg significantly decreased the surviving fraction of breast tumor cells. Bortezomib 1.0 mg/kg administrated weekly for 4 weeks reduces tumor growth by 60% in murine xenograft models of prostate cancer. 1.0 mg/kg Bortezomib administration for 4 weeks results in a 72% or 84% reduction in pancreatic cancer murine xenografts growth, as well as an increase in tumor cell apoptosis. 1.0 mg/kg Bortezomib treatment results in significant inhibition of human plasmacytoma xenograft growth, increase in tumor cells apoptosis and overall survival, and a decrease in tumor angiogenesis. [3]
臨床試験 A phase I study of weekly subcutaneous Bortezomib in patients with steroid-refractory or -dependent chronic graft versus host disease is currently in recruiting.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[4]

Kinetic Methods In a typical kinetic run, 2.00 mL of assay buffer (20 mM HEPES, 0.5 mM EDTA, 0.035% SDS, pH 7.8) and Suc-Leu-Leu-Val-Tyr-AMC in DMSO are added to a 3 mL fluorescence cuvette, and the cuvette is placed in the jacketed cell holder of a fluorescence spectrophotometer. Reaction temperature is maintained at 37℃ by a circulating water bath. After the reaction solution has reached thermal equilibrium (5 minutes), 1 μL−10 μL of the stock enzyme solution is added to the cuvette. Reaction progress is monitored by the increase in fluorescence emission at 440 nm (λex= 380 nm) that accompanies cleavage of AMC from peptide-AMC substrates.

細胞アッセイ:

[5]

細胞株 Human multiple myeloma cells line U266
濃度 ~10 μM
反応時間 2 days
実験の流れ

The inhibitory effect of Bortezomib on cell growth is assessed by measuring MTT dye absorbance of the cells. Cells from 48-hour cultures are pulsed with 10 μL of 5 mg/mL MTT to each well for the last 4 hour of 48-hour cultures, followed by 100 μL of isopropanol containing 0.04 N HCl. Absorbance is measured at 570 nm using a spectrophotometer.

動物実験:

[3]

動物モデル Human plasmacytoma xenografts RPMI 8226
製剤 Saline
投薬量 1 mg/kg
投与方法 i.v. twice weekly for 4 weeks, then once weekly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Bortezomib (PS-341) SDF
分子量 384.24
化学式

C19H25BN4O4

CAS No. 179324-69-7
保管 3年-20℃
2年-80℃in solvent
別名 LDP-341, MLM341
溶解度 (25°C) * In vitro DMSO 76 mg/mL (197.79 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 B-​[(1R)​-​3-​methyl-​1-​[[(2S)​-​1-​oxo-​3-​phenyl-​2-​[(2-​pyrazinylcarbonyl)​amino]​propyl]​amino]​butyl]​-boronic acid

文献中の引用 (142)

Frequently Asked Questions

  • Question 1
    On your website, it is mentioned that Bortezomib should be prepared at a concentration of 5 mg/ml in 2% DMSO/30% PEG300/ddH2O for in vivo use. But on the product sheet we received with the compound, it is mentioned: 5mg/ml in 0.5% methylcellulose, 0.2% tween 80. So which is the correct preparation buffer?

    Answer: S1013 Bortezomib in 2% DMSO+30% PEG 300+ddH2O at 5 mg/ml is a clear solution, and it in 0.5% methylcellulose+0.2% Tween 80 is a suspension. Please choose the suitable vehicle according to your administration route. When you prepare the clear solution, please dissolve Bortezomib in DMSO first, make sure it dissolves well, warm it up to 45 degree and/or sonicate if necessary, then add PEG, mix well, and finally add water.

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Tags: Bortezomib (PS-341)を買う | Bortezomib (PS-341)供給者 | Bortezomib (PS-341)を購入する | Bortezomib (PS-341)費用 | Bortezomib (PS-341)生産者 | オーダーBortezomib (PS-341) | Bortezomib (PS-341)代理店
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