Bortezomib (PS-341) 化学構造
分子量: 384.24

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Quality Control & MSDS

製品説明

  • Compare Proteasome Inhibitors
    Proteasome製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Bortezomib (PS-341)は、強力なプロテアソーム阻害剤で、Kiが0.6nMです。
ターゲット

20S proteasome

IC50

0.6 nM (Ki) [1]

In vitro試験 Bortezomib, a boronic acid dipeptide, is a highly selective, reversible inhibitor of the 26S proteasome which primarily functions in the degradation of mis-folded proteins and is essential for the regulation of the cell cycle. Exposure to Bortezomib has been shown to stabilize p21, p27, and p53, as well as the proapoptotic Bid and Bax proteins, caveolin-1, and inhibitor κB-α, which prevents activation of nuclear factor κB-induced cell survival pathways. Bortezomib also promotes the activation of the proapoptotic c-Jun-NH2 terminal kinase, as well as the endoplasmic reticulum stress response. Alteration of the levels of these cellular proteins leads to inhibition of proliferation, migration, and promotion of apoptosis of cancer cells. [2] Bortezomib is shown to penetrate into cells and inhibit proteasome-mediated intracellular proteolysis of long-lived proteins with a concentration that inhibits 50% of the proteolysis of ∼0.1 μM. The average growth inhibition of 50% value for Bortezomib across the entire panel of 60 cancer cell lines derived from multiple human tumors from the US National Cancer Institute (NCI) is 7 nM. Treatment of PC-3 cells with Bortezomib (100 nM) for 8 h results in the accumulation of cells in G2-M, with a corresponding decrease in the number of cells in G1. Bortezomib kills PC-3 cells at 24 and 48 hr with IC50 of 100 and 20 nM, respectively. Bortezomib induces nuclear condensation at 16–24 hr after treatment. Bortezomib treatment leads to PARP cleavage in a time-dependent manner with concentrations as low as 100 nM being effective at 24 hr. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
MCF-7 MWrDfZRwfG:6aXOgRZN{[Xl? M2XnfVUxKM7:TR?= NUDMdoIzPDhiaB?= MWLEUXNQ MWfLbYxteyClZXzsd{BjgSCvb4LlJJRp[W5iOUml M3;KSFExPDl7NkSz
OVCA 429 M3HBbWZ2dmO2aX;uJGF{e2G7 MlLWN|AxKG6P MlO2OFghcA>? NVjuZmluTE2VTx?= NXP3WlllTGm|coXweJMhcW62YXP0JI12dHSrY3XscJVt[XJidIXtc5Ihe3CqZYLvbYR{ M2TTV|ExQTl7N{[2
RPMI8226 Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrnc5d3OTByIH7N M3PnTlQ5KGh? NXfI[2xETE2VTx?= MmTQTWM2OD1|MDDuUS=> MmrtNVE{ODZ2OEm=
Dox40 M2Tzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX[xNFAhdk1? NXjnclkxPDhiaB?= NGjr[5hFVVOR MXTJR|UxRTRyIH7N MnvrNVE{ODZ2OEm=
MR20 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVixNFAhdk1? M2HpblQ5KGh? M2[4T2ROW09? MUDJR|UxRTJyIH7N MmLaNVE{ODZ2OEm=
LR5 M3nYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYWxNFAhdk1? MUW0PEBp MnzRSG1UVw>? NGq1UXhKSzVyPUKwJI5O MWexNVMxPjR6OR?=
U266 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rVTlExOCCwTR?= MnnoOFghcA>? NFHqdnBFVVOR NHnXOIZKSzVyPUOgcm0> MUKxNVMxPjR6OR?=
IM-9 M1fOdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrrZWsyOTByIH7N NELKXJo1QCCq NGPxZ21FVVOR MmjRTWM2OD14IH7N M4LZXVEyOzB4NEi5
Hs Sultan M{\PT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmxNFAhdk1? M2GxNVQ5KGh? MVfEUXNQ Mlv5TWM2OD1{MDDuUS=> M2G3fVEyOzB4NEi5
PAM-LY2 NHPz[HVHfW6ldHnvckBCe3OjeR?= NUDuT413OTByIH7N NFP1fnQyOiCq NYPNZotKTE2VTx?= NVjUbpBnUW6qaXLpeJMhVkZvzsrCJIFkfGm4YYTpc44> M4O1dlEyOzVyOUGz
PAM 212 Mlu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVexNFAhdk1? M2[5WFczKGh? MXTEUXNQ NWK5WHJpUW6qaXLpeJMh[2WubDD2bYFjcWyrdIm= NY\wUVVlOTF|NUC5NVM>
PAM-LY2 M1vHU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVuxNFAhdk1? MmC2O|IhcA>? MVjEUXNQ NVPx[WRvUW6qaXLpeJMh[2WubDD2bYFjcWyrdIm= Mo\XNVE{PTB7MUO=
B4B8 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT5XnU5OTByIH7N MlfrO|IhcA>? NI\JPXBFVVOR MlrYTY5pcWKrdIOgZ4VtdCC4aXHibYxqfHl? NHj0N|UyOTN3MEmxNy=>
B7E3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHXNVAxKG6P NFzpR5I4OiCq M2rtZ2ROW09? MnP3TY5pcWKrdIOgZ4VtdCC4aXHibYxqfHl? NXzS[21{OTF|NUC5NVM>
UM-SCC-9 NXXs[2MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWKxNFAhdk1? MlLSO|IhcA>? NVjifW92TE2VTx?= NWnwUpJXUW6qaXLpeJMh[2WubDD2bYFjcWyrdIm= NIS2cVIyOTN3MEmxNy=>
UM-SCC-11B NHfHWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[xNFAhdk1? MkTXO|IhcA>? NVHFS|ZMTE2VTx?= NWLZWndbUW6qaXLpeJMh[2WubDD2bYFjcWyrdIm= MU[xNVM2ODlzMx?=
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ARH77 M3;UNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D3RVUxOCCwZz;tcC=> NFzhUG01QCCq NWDJeHduTE2VTx?= NGGxcJNKdmirYnn0d{Bk\WyuIHfyc5d1cA>? MkLhNVI3OzF4MUm=
WAD-1 NH3hbHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHEcHp2PTByIH7nM41t M2jGZVQ5KGh? NX7ZT4JYTE2VTx?= NFm5WJpKdmirYnn0d{Bk\WyuIHfyc5d1cA>? MmLBNVI3OzF4MUm=
U266/LR7 NFqwZmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37hdlUxOCCwZz;tcC=> NXjBfGdXPDhiaB?= NWexTmdYTE2VTx?= MoniTY5pcWKrdIOgZ4VtdCCpcn;3eIg> MWmxNlY{OTZzOR?=
U266/dox4 NH7afGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2P5dFUxOCCwZz;tcC=> MVi0PEBp MUnEUXNQ Ml\MTY5pcWKrdIOgZ4VtdCCpcn;3eIg> MY[xNlY{OTZzOR?=
RPMI8226/LR5 M1m3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXq1NFAhdmdxbXy= MUK0PEBp NUPSb3dSTE2VTx?= NIDEVpBKdmirYnn0d{Bk\WyuIHfyc5d1cA>? MWqxNlY{OTZzOR?=
H460 MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnsSo0yOCEQvF2= M3P0WlczKGh? NUnFbZBQTE2VTx?= MYPJR|UxRTFyMDDuUS=> NELUPI4yOjZ|MU[yNC=>
H358 MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXO4UlFSOTBizszN MWi3NkBp MkKxSG1UVw>? MonnTWM2OD15MDDuUS=> NXHCSmJrOTJ4M{G2NlA>
H322 NVfaXXV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrDU|EyOCEQvF2= MoXZO|IhcA>? MUDEUXNQ M1\EOWlEPTB;NkKwJI5O NWrYXmszOTJ4M{G2NlA>
H460 NXHUWmp4TnWwY4Tpc44hSXO|YYm= Mn\0NVAxKG6P MlLYNlQhcA>? M{Xmc2ROW09? M1:0[mlv\HWlZYOgS|IuVS2yaHHz[UBienKnc4SgZY5lKHS3YoXsbY4h[XO|ZX3icJku\Gm|YYPz[Y1jdHl? M2POclEzPjNzNkKw
LNCap-Pro5 MoDqSpVv[3Srb36gRZN{[Xl? NG\EfpMyKM7:TR?= M2nYXFQhcA>? MXjEUXNQ MYnTeIFjcWyrenXzJJA2Ow>? M{j6U|E1PjF{NUOy
T29 M2TZTWFxd3C2b4Ppd{BCe3OjeR?= MnTwOVAhdk1? NHjGemU1QCCqIB?= MoCySG1UVw>? MXXJcoR2[2W|IHPlcIwh[XCxcITvd4l{ MlXwNVY4PzhzN{m=
T29Kt1 MVjBdI9xfG:|aYOgRZN{[Xl? NHLuN2k2OCCwTR?= MYS0PEBpKA>? M1TTSmROW09? NULtWGREUW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= MlXYNVY4PzhzN{m=
HCT116 NFPvc5lCeG:ydH;zbZMhSXO|YYm= Mk[4OVAhdk1? NVuzOVdPPDhiaDC= M3rmSWROW09? M4XZOGlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? MknxNVY4PzhzN{m=
HKe-3 NHT2TohCeG:ydH;zbZMhSXO|YYm= NWrhNo0zPTBibl2= NU[0W4NDPDhiaDC= MYPEUXNQ NUfLUIFyUW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= NIq1eXoyPjd5OEG3PS=>
NB-1691 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoCxNUDPxE1? NFvlW2o4OiCq MonzTY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJJRwKDVn NHHlNXEyPzZ6OU[4OC=>
CHLA-255 MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjUNUDPxE1? M{LkXlczKGh? MmDwTY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJJRwKDJn NF\UUoQyPzZ6OU[4OC=>
SK-N-AS M4LZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TwSlEh|ryP M1TndVczKGh? MkS5TY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJJRwKDFyJR?= NX3WZYtGOTd4OEm2PFQ>
NB-1691 MmjoSpVv[3Srb36gRZN{[Xl? M1TLXVExKG6P MXuyOEBp M4e5dHNq\26rZnnjZY51dHlicnXkeYNmeyClZXzsd{BqdiC2aHWgS|AwTzFicHjhd4U> M1zHd|E4Pjh7Nki0
CHLA-255 MUHGeY5kfGmxbjDBd5NigQ>? MoHUNVAhdk1? MU[yOEBp NWjhOHE5VW:mZYP0cJkhemWmdXPld{Bk\WyuczDpckB1cGViR{CvS|EheGijc3W= NFTBUJIyPzZ6OU[4OC=>
RPMI 8226 NXLBS5Z6TnWwY4Tpc44hSXO|YYm= NFnDXmUzOCCwTR?= M4PFN|ghcA>? NUTRW3hIW2mpbnnmbYNidnSueTDlcohidmOnczDOSk3PwkJiYXP0bZZqfHl? M1Xz[VE6PDN4MEWw
MM.1S MY\GeY5kfGmxbjDBd5NigQ>? NW\qeHJlOjBibl2= NGfkc|Y5KGh? M3KxWXNq\26rZnnjZY51dHliZX7oZY5k\XNiTl[t{tpDKGGldHn2bZR6 NV;Pd5hSOTl2M{[wOVA>
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OPM1 MlPXSpVv[3Srb36gRZN{[Xl? M3PVeVIxKG6P M2S3N|ghcA>? MlfJV4lodmmoaXPhcpRtgSCnbnjhcoNmeyCQRj5OvmIh[WO2aY\peJk> NYXReIVLOTl2M{[wOVA>
INA6 MVHGeY5kfGmxbjDBd5NigQ>? Mo\DNlAhdk1? NHrSWpg5KGh? NE[wNZhUcWewaX\pZ4FvfGy7IHXubIFv[2W|IF7GMe67SiCjY4Tpeol1gQ>? NWOwfpJlOTl2M{[wOVA>
OPM2 MXXGeY5kfGmxbjDBd5NigQ>? Ml\6NlAhdk1? MWC4JIg> NFrWOIhUcWewaX\pZ4FvfGy7IHXubIFv[2W|IF7GMe67SiCjY4Tpeol1gQ>? M17UNFE6PDN4MEWw
RPMI 8226 MVPGeY5kfGmxbjDBd5NigQ>? M3jtTlIxKG6P NEDOUYs5KGh? M1uxOmlv\HWlZYOgSG5CKHO7boTo[ZNqew>? MYOxPVQ{PjB3MB?=
BaF/3 M{O3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT0XXZIOTByIH7N NEe1Z2c1QCCq NUDWRXRtUUN3ME22MlIhdk1? NVXsZ4R7OjB|MEW2PVI>
BaF/3-p210 M1nleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofDNVAxKG6P MYS0PEBp MYHJR|UxRTRwNzDuUS=> NHLjOWkzODNyNU[5Ni=>
TCC-S NEL1bo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2njd|ExOCCwTR?= MoTuOFghcA>? MlW5TWM2OD1{Lkigcm0> M4qxfVIxOzB3Nkmy
BaF/3 NG\lbWFHfW6ldHnvckBCe3OjeR?= NHHqXWI3KG6P NX\lNHdsPDhiaB?= NHTKS|VKdmS3Y3XzJIEh\3KnYYSgS|Eh[2WubD3jfYNt\SCjcoLld5Q> NHKyUnQzODNyNU[5Ni=>
BaF/3-p210 MojOSpVv[3Srb36gRZN{[Xl? NI\DdZI3KG6P MmrvOFghcA>? NX36N3VjUW6mdXPld{BiKHOuaXfoeEBIOSClZXzsMYN6[2ynIHHydoV{fA>? NXT4XHBIOjB|MEW2PVI>
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Raji MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfFOYUyKM7:TR?= MXWyOEBp NIDBTpRT\WS3Y3XzJINmdGxidnnhZoltcXS7wrC= NX3UbVZ3OjFzN{C5PFg>
LCL-1 M2\PWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX[xJO69VQ>? MYmyOEBp MWHS[YR2[2W|IHPlcIwhfmmjYnnsbZR6yqB? NGLMVJYzOTF5MEm4PC=>
LCL-2 NWqwXVFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DVVlEh|ryP MWGyOEBp MmnYVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi MWOyNVE4ODl6OB?=
BJAB M13Dcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfQNUDPxE1? NVvSdZZOOjRiaB?= MoPLVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi MmnlNlEyPzB7OEi=
SNT-13 NUDXclhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjvNUDPxE1? NHT4NpQzPCCq M4DR[HJm\HWlZYOgZ4VtdCC4aXHibYxqfHoEoB?= NEDG[pMzOTF5MEm4PC=>
SNT-16 MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjRflZsOSEQvF2= NWjWSlB{OjRiaB?= Ml;NVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi M363XlIyOTdyOUi4
Jurkat M33FOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3yd2oyKM7:TR?= NVjqXnpYOjRiaB?= M2HEZXJm\HWlZYOgZ4VtdCC4aXHibYxqfHoEoB?= NULOZlBzOjFzN{C5PFg>
KAI-3 M2fmbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Dr[|Eh|ryP NVnzRXBWOjRiaB?= MVTS[YR2[2W|IHPlcIwhfmmjYnnsbZR6yqB? NV3SSYVlOjFzN{C5PFg>
SNK-6 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fpU|Eh|ryP NVTSbZg3OjRiaB?= M1rJPXJm\HWlZYOgZ4VtdCC4aXHibYxqfHoEoB?= MlXaNlEyPzB7OEi=
KHYG-1 NW\jSZVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlKxNUDPxE1? NYfZS5RDOjRiaB?= NWjITndkWmWmdXPld{Bk\WyuII\pZYJqdGm2edMg MkLwNlEyPzB7OEi=
SNT-16 M3i2e2Fxd3C2b4Ppd{BCe3OjeR?= NHvmUYoyKM7:TR?= MUi2JIg> MnL6TY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? M{Wxd|IyOTdyOUi4
Jurkat MlnURZBweHSxc3nzJGF{e2G7 NWT6NpVROSEQvF2= MoPlOkBp MnfRTY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? NVf0bXJXOjFzN{C5PFg>
KAI-3 NHn5RY5CeG:ydH;zbZMhSXO|YYm= NYHs[HpIOSEQvF2= Mn;ZOkBp MonmTY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? M{\NNVIyOTdyOUi4
KHYG-1 Mn7xRZBweHSxc3nzJGF{e2G7 MlvXNUDPxE1? MkTXOkBp M4\vR2lv\HWlZYOgZ4VtdCCjcH;weI9{cXN? NVX3N|NDOjFzN{C5PFg>
SNT-13 NVXkTow6SW62aY\pdoFtKEG|c3H5 M3npe|Eh|ryP M2O1TFI1KGh? MYDJcoR2[2W|IHz5eIlkKGmwZnXjeIlwdiCxZjDFRnY> MmD6NlEyPzB7OEi=
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A375 MVHBeZRweGijZ4mgRZN{[Xl? NHX1fJcyOCCwTR?= Mme1NVIhcA>? M{TyNWlv\HWlZYOg[o9zdWG2aX;uJI9nKGG3dH;wbIFod3OxbXXz NVH1RYxTOjNyN{mwPFM>
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Hut-78 MXLGeY5kfGmxbjDBd5NigQ>? NFe2WYEyODBibl2= NVTMXXBFOjRiaB?= M17JeGROW09? M1XQTWRwf26{ZXf1cIF1\XNiVFfGMe6zOSCjbnSgTWwuOTBiZYjwdoV{e2mxbh?= MVSyOVY5OTN|NR?=
H9 M4LDRmZ2dmO2aX;uJGF{e2G7 MY[xNFAhdk1? NYfNNppIOjRiaB?= MV;EUXNQ NWHtZ|Q1TG:5boLl[5Vt[XSnczDUS2Yu|rJzIHHu[EBKVC1zMTDlfJBz\XO|aX;u Mn3mNlU3QDF|M{W=
HH NXzDV3h2TnWwY4Tpc44hSXO|YYm= MXOxNFAhdk1? MWGyOEBp MW\EUXNQ NU[1NIdU\G:5boLl[5Vt[XSnczDUS2Yu|rJzIHHu[EBKVC1zMjDlfJBz\XO|aX;u MXOyOVY5OTN|NR?=
Hut-78 MmG5UYloemG2aX;uJGF{e2G7 MUGxNFAhdk1? NWfDSYpxOjRiaB?= MULEUXNQ NEjV[ZZT\WS3Y3XzJINmdGxibXnndoF1cW:wIHL5JFgx6oDVOUCl NEXkcpIzPTZ6MUOzOS=>
HH NXTGSJRWVWmpcnH0bY9vKEG|c3H5 NVTVZXlKOTByIH7N MnHaNlQhcA>? M3TMdWROW09? M2TXcXJm\HWlZYOgZ4VtdCCvaXfyZZRqd25iYomgPFDjiJN7MTW= MorGNlU3QDF|M{W=
U937 MonNSpVv[3Srb36gRZN{[Xl? M363WVExOCCwTR?= NEi2[HM3KGh? NUDjWJF7UW6mdXPld{BKVC16IHX4dJJme3Orb36gbY4hVFCVLYP0bY12dGG2ZXSgWVk{PyCvYXPyc5Bp[Wencx?= M4nJTlI2PzlzNEe3
human PBMC M{O3UGZ2dmO2aX;uJGF{e2G7 NITDPYEyODBibl2= NFq2cFAzPCCq NFPybVFKdmS3Y3XzJGlNNThicnXs[YF{\Q>? NHvaWVYzPTd7MUS3Oy=>
ES6 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX35fJV{UUN3ME2wMlAxOjFibl2= MmrzV2FPT0WU
SK-UT-1 MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XaO2lEPTB;MD6xOlMhdk1? NU[5R4dQW0GQR1XS
SH-4 M2DZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMUezJI5O MmrDV2FPT0WU
TE-9 M4nMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f4UWlEPTB;MD6xPFIhdk1? MWDTRW5ITVJ?
A253 M2fBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXs[VU6UUN3ME2wMlIxQCCwTR?= MnLhV2FPT0WU
no-10 MkX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LPd2lEPTB;MD6yNUBvVQ>? NV\mV3JDW0GQR1XS
MMAC-SF NV6xOYlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[ySodKSzVyPUCuNlE3KG6P NVf3Z4s2W0GQR1XS
A101D NGj4NGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\XSGhVUUN3ME2wMlIzPSCwTR?= NGS1doJUSU6JRWK=
NTERA-S-cl-D1 NGjId|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXjc4JKSzVyPUCuNlQ{KG6P NGrmd2lUSU6JRWK=
8-MG-BA MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M12we2lEPTB;MD6yOUBvVQ>? Mm\0V2FPT0WU
KNS-42 NUDyWGkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLlWodPUUN3ME2wMlI2QCCwTR?= MlO4V2FPT0WU
LXF-289 NFLTOpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHE[otKSzVyPUCuNlY6KG6P MWHTRW5ITVJ?
OVCAR-4 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHxe|Z2UUN3ME2wMlI5QSCwTR?= NVTQUIloW0GQR1XS
LOUCY MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLqXYV6UUN3ME2wMlI6OyCwTR?= M1m5UnNCVkeHUh?=
BB65-RCC Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL0TWM2OD1yLkOwOEBvVQ>? NGG1[YtUSU6JRWK=
D-542MG NFTSeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXmVIpKSzVyPUCuN|I6KG6P MoT1V2FPT0WU
ONS-76 M3;3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\xTWM2OD1yLkOzJI5O NILQNnFUSU6JRWK=
BB30-HNC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PnemlEPTB;MD6zN|Uhdk1? MUnTRW5ITVJ?
KS-1 Mo\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrMdGZRUUN3ME2wMlM1KG6P MVnTRW5ITVJ?
A388 NVjHPWN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TvSGlEPTB;MD6zOVYhdk1? MlPlV2FPT0WU
ES8 NGW2VWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j5WWlEPTB;MD60JI5O NGPBbpNUSU6JRWK=
MZ2-MEL M17MNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3ETWM2OD1yLkSwO{BvVQ>? Ml7XV2FPT0WU
HCC2998 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwNEGyJI5O Mmq3V2FPT0WU
D-247MG NGfyW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjETWM2OD1yLkSxN{BvVQ>? NVO5PYZ{W0GQR1XS
ACN M2K5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;4O2lEPTB;MD60NVchdk1? M1TQS3NCVkeHUh?=
LB2518-MEL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS4TWM2OD1yLkSyOUBvVQ>? MnLkV2FPT0WU
ES1 Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYWzN5N5UUN3ME2wMlQ{KG6P NW\0cG5DW0GQR1XS
HCE-T M{ezN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrkeFJKSzVyPUCuOFM6KG6P NFjqeHhUSU6JRWK=
OS-RC-2 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLuTWM2OD1yLkS0JI5O NYLY[5FTW0GQR1XS
MFH-ino NUOwVJd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwNESzJI5O NWrOeJBUW0GQR1XS
OCUB-M NWrpSmVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLjXYdFUUN3ME2wMlQ1PyCwTR?= NEXzcYFUSU6JRWK=
CP66-MEL MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPxUWVEUUN3ME2wMlQ4OyCwTR?= NH6ycGFUSU6JRWK=
LB771-HNC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPvfZlKSzVyPUCuOFc1KG6P MlywV2FPT0WU
DSH1 M{XRfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTyTWM2OD1yLkS4JI5O NEfGPG5USU6JRWK=
HUTU-80 NGT5R4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFqw[HpKSzVyPUCuOVM{KG6P MWPTRW5ITVJ?
CESS MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\Y[mlEPTB;MD61N|ghdk1? M4Pr[XNCVkeHUh?=
NCI-H747 NYe1bGlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3H5cWlEPTB;MD61N|khdk1? MnzaV2FPT0WU
HT-144 NIHMXnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fkPWlEPTB;MD61O|Yhdk1? NXnvfW4yW0GQR1XS
COLO-829 NI\QVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwNkG0JI5O M3PHbnNCVkeHUh?=
A4-Fuk NIf5O5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrJTWM2OD1yLk[yN{BvVQ>? NIm3Z3JUSU6JRWK=
GI-ME-N MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq3fHZlUUN3ME2wMlY{PCCwTR?= M3vaVnNCVkeHUh?=
LB831-BLC NVu0bpVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoO3TWM2OD1yLk[0NUBvVQ>? MlLUV2FPT0WU
HOP-62 NYe2OppmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz1Z5dCUUN3ME2wMlY1PyCwTR?= MoDYV2FPT0WU
BB49-HNC M173UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfwTWM2OD1yLk[1NkBvVQ>? MnXVV2FPT0WU
D-336MG M2Xkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwNkW3JI5O M2jMS3NCVkeHUh?=
TK10 NUPMUFNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwNke5JI5O NIHKR3lUSU6JRWK=
Ramos-2G6-4C10 MnezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r1O2lEPTB;MD62PVMhdk1? MmXEV2FPT0WU
LB373-MEL-D NWDJUVJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T4UmlEPTB;MD63JI5O MU\TRW5ITVJ?
SF126 M4OyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnCTWM2OD1yLkewNUBvVQ>? NHrMepFUSU6JRWK=
UACC-257 NUD1elNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm1fW9HUUN3ME2wMlcyKG6P NYL1Z4VWW0GQR1XS
KINGS-1 NF\OenhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwN{KyJI5O NEHGXFVUSU6JRWK=
LS-513 M4r1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXSTWM2OD1yLkezPUBvVQ>? NHfHUJBUSU6JRWK=
GI-1 MlzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4iyTmlEPTB;MD63OlQhdk1? NGTyOYdUSU6JRWK=
ES7 MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwN{[2JI5O MlTsV2FPT0WU
LB2241-RCC M2DWdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPWVldKSzVyPUCuPFA1KG6P M{LheHNCVkeHUh?=
D-263MG M16zTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPFWIhKSzVyPUCuPFA4KG6P M{KyOHNCVkeHUh?=
SW684 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwOEKxJI5O NHTkRnlUSU6JRWK=
ML-2 NWfqb21mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP2cJJFUUN3ME2wMlgzOSCwTR?= NFrQdm5USU6JRWK=
SK-LMS-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwOEW0JI5O NIC4boNUSU6JRWK=
TE-5 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHmTWM2OD1yLki2OUBvVQ>? M17ifnNCVkeHUh?=
QIMR-WIL NHLIOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXewd2tvUUN3ME2wMlg5QSCwTR?= NXP1V5duW0GQR1XS
NCI-H1355 MkHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;uXHdKSzVyPUCuPFk2KG6P NHrCfWtUSU6JRWK=
SNB75 M{PiXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jZfmlEPTB;MD65NVIhdk1? MVrTRW5ITVJ?
RXF393 MkPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHZTWM2OD1yLkmxOEBvVQ>? NUfTcJpQW0GQR1XS
IST-MEL1 NHzV[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzKOo11UUN3ME2wMlkyPyCwTR?= M4j4eHNCVkeHUh?=
SF268 NIHhcplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DUbGlEPTB;MD65NlMhdk1? M3PiOnNCVkeHUh?=
KALS-1 NHzzcHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwOUK1JI5O M4X6cXNCVkeHUh?=
HC-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwOUe1JI5O NVjnSYlOW0GQR1XS
SW872 M3L0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzMU2FKSzVyPUCuPVk3KG6P MUjTRW5ITVJ?
PSN1 NWTjUGxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\iU3dNUUN3ME2xMlAyKG6P MWTTRW5ITVJ?
TE-1 M4fUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPWTWM2OD1zLkCzJI5O MWLTRW5ITVJ?
TE-10 NHvZfXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3s[XlKUUN3ME2xMlA{KG6P NWThR|ZjW0GQR1XS
RKO M2nFRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPCTWM2OD1zLkC2JI5O NHXXUYtUSU6JRWK=
LC-2-ad NFf0SYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfpTWM2OD1zLkC4JI5O NX22W5RUW0GQR1XS
SK-MM-2 NIDE[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv4TWM2OD1zLkC5JI5O NU\tXJdyW0GQR1XS
VA-ES-BJ MnG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTFwMEmgcm0> MYXTRW5ITVJ?
MZ7-mel MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fhUWlEPTB;MT6wPUBvVQ>? Ml7MV2FPT0WU
D-392MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTFwMTDuUS=> MlXaV2FPT0WU
CCRF-CEM MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXpPJVKSzVyPUGuNVMhdk1? MXnTRW5ITVJ?
EM-2 NYHWdHV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX3TWM2OD1zLkG2JI5O MWDTRW5ITVJ?
HAL-01 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTrTWM2OD1zLkG4JI5O MVrTRW5ITVJ?
TE-8 M3zFUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTFwMUmgcm0> NGnwTJJUSU6JRWK=
NCI-H1882 M3Xvcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwMjDuUS=> MXvTRW5ITVJ?
Daudi NGK4PHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;vTWM2OD1zLkKyJI5O MnnUV2FPT0WU
BL-41 NXnVdppkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnIe|VwUUN3ME2xMlI2KG6P M3Xy[XNCVkeHUh?=
SR MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzBTWM2OD1zLkK1JI5O MUfTRW5ITVJ?
KM12 NFLIR5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rhNmlEPTB;MT6yO{BvVQ>? NYm4fYVkW0GQR1XS
K5 NUPFRYFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3kU4dKSzVyPUGuNlghdk1? MVXTRW5ITVJ?
A3-KAW NH7BZ5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV64S5dzUUN3ME2xMlI5KG6P NWDmcJFoW0GQR1XS
CMK MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7OTWM2OD1zLkK5JI5O MnvWV2FPT0WU
Calu-6 M1KxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3RfFhKSzVyPUGuNlkhdk1? NGHvSWFUSU6JRWK=
IST-SL2 NHPnfoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;EWWdKSzVyPUGuN|Ehdk1? M3:1UnNCVkeHUh?=
OPM-2 MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFwM{Ogcm0> MYrTRW5ITVJ?
DU-4475 M4jacWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnTNnhKSzVyPUGuN|Yhdk1? NH3hT5VUSU6JRWK=
ECC12 MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7Xd3RKSzVyPUGuN|chdk1? MlvrV2FPT0WU
L-540 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEOxUppKSzVyPUGuN|chdk1? MmfZV2FPT0WU
CAS-1 NETOeGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T5fGlEPTB;MT6zO{BvVQ>? NUO1e4FSW0GQR1XS
PF-382 M4fCXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HrRmlEPTB;MT60O{BvVQ>? NXfTZWFlW0GQR1XS
LS-411N M1TTOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDtd|I1UUN3ME2xMlU{KG6P NGLkSnpUSU6JRWK=
NCI-H69 NI\QflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfTcIpKSzVyPUGuOVQhdk1? NWDEdpIzW0GQR1XS
NB12 NUPQfGVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Swe2lEPTB;MT61OkBvVQ>? NE\FVpVUSU6JRWK=
HEL M1nMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTFwNkGgcm0> M2HFUHNCVkeHUh?=
GCIY M1vCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDLR3ZKSzVyPUGuOlIhdk1? MYHTRW5ITVJ?
EHEB NITGOItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LyNWlEPTB;MT62O{BvVQ>? M3HvOnNCVkeHUh?=
TGBC1TKB NX3RTHVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTFwN{Ggcm0> MlziV2FPT0WU
KURAMOCHI M3i2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{WxemlEPTB;MT63NkBvVQ>? MUTTRW5ITVJ?
U-266 M3LZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrBTWM2OD1zLke2JI5O MWfTRW5ITVJ?
LC4-1 M{nHcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwN{mgcm0> Mn;UV2FPT0WU
NCI-H2126 M330T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHiTWM2OD1zLkigcm0> M2TrXHNCVkeHUh?=
NCI-H1092 M2rKOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFwODDuUS=> M{\3[3NCVkeHUh?=
GB-1 M3PDdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFwOEGgcm0> NVnnflFOW0GQR1XS
MV-4-11 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3SyOWlEPTB;MT64NkBvVQ>? M37ZbXNCVkeHUh?=
Becker MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFwOEOgcm0> MYnTRW5ITVJ?
MPP-89 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TaPWlEPTB;MT64PUBvVQ>? MUXTRW5ITVJ?
BE-13 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFwOUOgcm0> NFvKTnNUSU6JRWK=
697 NFy1eFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTFwOUmgcm0> MlraV2FPT0WU
NKM-1 NVv3dIRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O1Z2lEPTB;MjDuUS=> NEjZNJBUSU6JRWK=
NB13 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvYTWM2OD1{IH7N M2rzRnNCVkeHUh?=
LS-123 NEnxV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwMEKgcm0> MWLTRW5ITVJ?
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SF539 NFjVW5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3zZ4tRUUN3ME2yNE43PyCwTR?= MV;TRW5ITVJ?
NCI-H446 NYT4NGtrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\RTWM2OD1{MT6xPEBvVQ>? Mnq1V2FPT0WU
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NCI-H82 NIfqPGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfUS3ZKSzVyPUKzMlAzKG6P Ml[2V2FPT0WU
HCC2157 NXzCO25PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTJ|LkGzJI5O Mn;sV2FPT0WU
EW-12 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJ|LkG3JI5O NV;qfJBMW0GQR1XS
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LS-1034 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X6cWlEPTB;MkWuO|Uhdk1? NXS0eIM2W0GQR1XS
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NCI-H719 NFq2W|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;EOWlEPTB;M{SuN|Ehdk1? NFHS[GhUSU6JRWK=
KARPAS-422 NIX1OG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfZfY1wUUN3ME2zOU4xPCCwTR?= M3Hq[HNCVkeHUh?=
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MHH-CALL-2 NGrFdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T4T2lEPTB;MUG1Mlchdk1? MXrTRW5ITVJ?
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NCI-H524 NHjHUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjJWo5FUUN3ME2xOVkvOSCwTR?= MX3TRW5ITVJ?
SCLC-21H NUjYUHdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorxTWM2OD1zNUmuOFEhdk1? MV;TRW5ITVJ?
NCI-H1304 M1zZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnRUFRJUUN3ME2xOlkvOjFibl2= MUPTRW5ITVJ?
NCI-H510A MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLSTWM2OD1zOEWuN|chdk1? M2fJbnNCVkeHUh?=
NCI-H209 MmPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF7Nj61NkBvVQ>? NHrwUYRUSU6JRWK=
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NCI-H1395 M2qxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnITWM2OD1{MUCuNVMhdk1? NF3a[5ZUSU6JRWK=
NCI-H1155 NVXZe216T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDHRZljUUN3ME2yN|AvOzJibl2= MX7TRW5ITVJ?
COR-L279 NH7KWmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkKwTWM2OD1{NUKuNVchdk1? MnHmV2FPT0WU
NCI-H1299 M3fOTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TZRmlEPTB;Mk[xMlcyKG6P MUDTRW5ITVJ?
EW-22 NGPKXHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJ4Mz63OUBvVQ>? NF7yO3pUSU6JRWK=
SK-MEL-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXwelRKSzVyPUK4NU46KG6P NVvvRZRuW0GQR1XS
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NCI-H187 M3;jc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHYOZlKUUN3ME2yPFcvODhibl2= M3mzV3NCVkeHUh?=
NCI-H2171 NF\YfoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nDSWlEPTB;Mki4MlkzKG6P MVzTRW5ITVJ?
LNCaP-Clone-FGC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJ7NT6yOkBvVQ>? M4PVbHNCVkeHUh?=
NCI-H1522 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTNyNz6wOUBvVQ>? MlX1V2FPT0WU
SCH MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGwTWM2OD1|MkKuNlIhdk1? MX\TRW5ITVJ?
THP-1 M3fZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHlTWM2OD1|MkKuOkBvVQ>? MX3TRW5ITVJ?
SNU-C1 NUjrUFJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7iPJhKSzVyPUO2Nk4xQSCwTR?= NFrpfXJUSU6JRWK=
CA46 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHXZWpKSzVyPUO3N{43OyCwTR?= MVTTRW5ITVJ?
NCI-H1963 NVX4PXo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3qwVWlEPTB;M{i2MlE6KG6P M3TmSHNCVkeHUh?=
DEL NFjQdotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYH6NHF7UUN3ME2zPVEvOjdibl2= MX7TRW5ITVJ?
TUR M2DlU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fhUWlEPTB;M{m2MlYyKG6P NGXzRmJUSU6JRWK=
NCI-H226 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLJTWM2OD12MEOuNlMhdk1? M1nzd3NCVkeHUh?=
COLO-668 MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXrTWM2OD12MEOuOVchdk1? Mn3ZV2FPT0WU
CPC-N NVHVT416T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDoc2hKSzVyPUSwN{44PyCwTR?= MWDTRW5ITVJ?
NCI-H889 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XYdGlEPTB;NE[xMlkzKG6P M1O4cnNCVkeHUh?=
J-RT3-T3-5 M2HSVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGyTWM2OD13M{KuOVchdk1? M{XBRXNCVkeHUh?=
MSTO-211H NYXHRnhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\nS2dKSzVyPUW3OE4zPiCwTR?= Mn;IV2FPT0WU
SCC-15 M{DSOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvwNWVKSzVyPU[2O{41PyCwTR?= NVezfnhzW0GQR1XS
SUP-T1 NVfVTZhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPHTWM2OD14OE[uNFQhdk1? NWX6boxrW0GQR1XS
DMS-153 NVHPSWJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTd2Nj64N{BvVQ>? NV;xRWV[W0GQR1XS
MS-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTd3OT60NkBvVQ>? MV;TRW5ITVJ?
TC-YIK NHvWVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfnTWM2OD15OEGuNFEhdk1? M1HIc3NCVkeHUh?=
RPMI-8866 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i0c2lEPTB;MUCwOk4zQCEQvF2= MofMV2FPT0WU
KY821 Mnr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTDTWM2OD1zMEO2MlA1KM7:TR?= MXzTRW5ITVJ?
P31-FUJ MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfMZ3BKSzVyPUGxNVIvPzVizszN MlW0V2FPT0WU
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U-698-M M1vhSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n0W2lEPTB;MkK2Nk4yPSEQvF2= MYjTRW5ITVJ?
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IMR-5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTN2MEmuOlIh|ryP M3ruUXNCVkeHUh?=
NCI-H1838 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULRZmFsUUN3ME20NVg3NjN{IN88US=> M3jJOHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 The anticancer effects of bortezomib as a single agent have been demonstrated in xenograft models of multiple myeloma, adult T-cell leukemia, lung, breast, prostate, pancreatic, head and neck, and colon cancer, and in melanoma. [2] Oral bortezomib 1.0 mg/ kg daily for 18 days causes tumor growth delays, as well as a decrease in the number of metastases in the Lewis lung cancer model. Bortezomib at a single dose of up to 5 mg/kg significantly decreased the surviving fraction of breast tumor cells. Bortezomib 1.0 mg/kg administrated weekly for 4 weeks reduces tumor growth by 60% in murine xenograft models of prostate cancer. 1.0 mg/kg Bortezomib administration for 4 weeks results in a 72% or 84% reduction in pancreatic cancer murine xenografts growth, as well as an increase in tumor cell apoptosis. 1.0 mg/kg Bortezomib treatment results in significant inhibition of human plasmacytoma xenograft growth, increase in tumor cells apoptosis and overall survival, and a decrease in tumor angiogenesis. [3]
臨床試験 A phase I study of weekly subcutaneous Bortezomib in patients with steroid-refractory or -dependent chronic graft versus host disease is currently in recruiting.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[4]

Kinetic Methods In a typical kinetic run, 2.00 mL of assay buffer (20 mM HEPES, 0.5 mM EDTA, 0.035% SDS, pH 7.8) and Suc-Leu-Leu-Val-Tyr-AMC in DMSO are added to a 3 mL fluorescence cuvette, and the cuvette is placed in the jacketed cell holder of a fluorescence spectrophotometer. Reaction temperature is maintained at 37℃ by a circulating water bath. After the reaction solution has reached thermal equilibrium (5 minutes), 1 μL−10 μL of the stock enzyme solution is added to the cuvette. Reaction progress is monitored by the increase in fluorescence emission at 440 nm (λex= 380 nm) that accompanies cleavage of AMC from peptide-AMC substrates.

細胞アッセイ:

[5]

細胞株 Human multiple myeloma cells line U266
濃度 ~10 μM
反応時間 2 days
実験の流れ

The inhibitory effect of Bortezomib on cell growth is assessed by measuring MTT dye absorbance of the cells. Cells from 48-hour cultures are pulsed with 10 μL of 5 mg/mL MTT to each well for the last 4 hour of 48-hour cultures, followed by 100 μL of isopropanol containing 0.04 N HCl. Absorbance is measured at 570 nm using a spectrophotometer.

動物実験:

[3]

動物モデル Human plasmacytoma xenografts RPMI 8226
製剤 Saline
投薬量 1 mg/kg
投与方法 i.v. twice weekly for 4 weeks, then once weekly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Bortezomib (PS-341) SDF
分子量 384.24
化学式

C19H25BN4O4

CAS No. 179324-69-7
保管 2年-20℃
6月-80℃in solvent
別名 LDP-341, MLM341
溶解度 (25°C) * In vitro DMSO 76 mg/mL (197.79 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 B-​[(1R)​-​3-​methyl-​1-​[[(2S)​-​1-​oxo-​3-​phenyl-​2-​[(2-​pyrazinylcarbonyl)​amino]​propyl]​amino]​butyl]​-boronic acid

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