Bortezomib (PS-341) 化学構造
分子量: 384.24

高品質保証

文献中の引用(142)

カスタマーフィードバック(20)

MSDS

製品説明

  • Compare Proteasome Inhibitors
    Proteasome製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Bortezomib (PS-341)は、強力なプロテアソーム阻害剤で、Kiが0.6nMです。
ターゲット

20S proteasome

IC50

0.6 nM (Ki) [1]

In vitro試験 Bortezomib, a boronic acid dipeptide, is a highly selective, reversible inhibitor of the 26S proteasome which primarily functions in the degradation of mis-folded proteins and is essential for the regulation of the cell cycle. Exposure to Bortezomib has been shown to stabilize p21, p27, and p53, as well as the proapoptotic Bid and Bax proteins, caveolin-1, and inhibitor κB-α, which prevents activation of nuclear factor κB-induced cell survival pathways. Bortezomib also promotes the activation of the proapoptotic c-Jun-NH2 terminal kinase, as well as the endoplasmic reticulum stress response. Alteration of the levels of these cellular proteins leads to inhibition of proliferation, migration, and promotion of apoptosis of cancer cells. [2] Bortezomib is shown to penetrate into cells and inhibit proteasome-mediated intracellular proteolysis of long-lived proteins with a concentration that inhibits 50% of the proteolysis of ∼0.1 μM. The average growth inhibition of 50% value for Bortezomib across the entire panel of 60 cancer cell lines derived from multiple human tumors from the US National Cancer Institute (NCI) is 7 nM. Treatment of PC-3 cells with Bortezomib (100 nM) for 8 h results in the accumulation of cells in G2-M, with a corresponding decrease in the number of cells in G1. Bortezomib kills PC-3 cells at 24 and 48 hr with IC50 of 100 and 20 nM, respectively. Bortezomib induces nuclear condensation at 16–24 hr after treatment. Bortezomib treatment leads to PARP cleavage in a time-dependent manner with concentrations as low as 100 nM being effective at 24 hr. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
MCF-7 NWDMNVFLS3m2b4TvfIlkKEG|c3H5 MVS1NEDPxE1? M4ThO|Q5KGh? NFfzeHlFVVOR NXnBSoNNU2mubIOgZ4VtdHNiYomgcY9z\SC2aHHuJFk6LQ>? MXOxNFQ6QTZ2Mx?=
OVCA 429 NEHZVVVHfW6ldHnvckBCe3OjeR?= Mn\0N|AxKG6P NUXzXmJVPDhiaB?= MnzRSG1UVw>? M13ubWRqe3K3cITzJIlvfGGldDDteYx1cWOnbHz1cIFzKHS3bX;yJJNxcGW{b3nkdy=> MkD5NVA6QTl5Nk[=
RPMI8226 M3PFfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHUWlZ4OTByIH7N MXO0PEBp NHm1T5NFVVOR NVvqVYtUUUN3ME2zNEBvVQ>? MonKNVE{ODZ2OEm=
Dox40 NH62dpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfQNVVCOTByIH7N MV60PEBp Mlq1SG1UVw>? MlXwTWM2OD12MDDuUS=> NUPBXGo1OTF|ME[0PFk>
MR20 NHnPTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP1NVAxKG6P MWm0PEBp NYDkZmtTTE2VTx?= MVPJR|UxRTJyIH7N NXL1bVFiOTF|ME[0PFk>
LR5 NFLLeFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL3V4FQOTByIH7N MmHqOFghcA>? NHHFcldFVVOR MV\JR|UxRTJyIH7N NG\nT2UyOTNyNkS4PS=>
U266 M{Xo[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7BS3hlOTByIH7N MYS0PEBp M3nKdWROW09? NVTBfpJSUUN3ME2zJI5O MlzWNVE{ODZ2OEm=
IM-9 MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3a[YlVOTByIH7N M4DD[FQ5KGh? NIGzTGVFVVOR MofzTWM2OD14IH7N NGDM[Y0yOTNyNkS4PS=>
Hs Sultan NX25PYxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnOW5gyODBibl2= NHv6PXg1QCCq M3\ZU2ROW09? MlrtTWM2OD1{MDDuUS=> MnrjNVE{ODZ2OEm=
PAM-LY2 NYXQV2x3TnWwY4Tpc44hSXO|YYm= NFnsbnMyODBibl2= MlTyNVIhcA>? MkLqSG1UVw>? MV;Jcohq[mm2czDOSk3PwkJiYXP0bZZifGmxbh?= NFPxcZYyOTN3MEmxNy=>
PAM 212 M4rIUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1f1WlExOCCwTR?= MoXxO|IhcA>? NHPjT4xFVVOR MoDtTY5pcWKrdIOgZ4VtdCC4aXHibYxqfHl? MXOxNVM2ODlzMx?=
PAM-LY2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXHOIMyODBibl2= MWq3NkBp MnfJSG1UVw>? MX7Jcohq[mm2czDj[YxtKH[rYXLpcIl1gQ>? MY[xNVM2ODlzMx?=
B4B8 NEPqW29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37BUFExOCCwTR?= NX75bWZ1PzJiaB?= NHzWOXpFVVOR NH:2c|RKdmirYnn0d{Bk\WyuII\pZYJqdGm2eR?= MY[xNVM2ODlzMx?=
B7E3 NITGbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTsNVAxKG6P M2\veVczKGh? MlzvSG1UVw>? NFzpS|ZKdmirYnn0d{Bk\WyuII\pZYJqdGm2eR?= NI\zb4oyOTN3MEmxNy=>
UM-SCC-9 MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPxU5YyODBibl2= NEHaN|k4OiCq M1;rWGROW09? NFvlUIFKdmirYnn0d{Bk\WyuII\pZYJqdGm2eR?= MonmNVE{PTB7MUO=
UM-SCC-11B NXXKVGtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWixNFAhdk1? M1fkeFczKGh? MWHEUXNQ M{H1NGlvcGmkaYTzJINmdGxidnnhZoltcXS7 Mn3XNVE{PTB7MUO=
H460 NH;6bFRHfW6ldHnvckBCe3OjeR?= MXWxNEDPxE1? MU[yOEBp MorBSG1UVw>? M2f2Nmlv\HWlZYOgRoNtNTJicHjvd5Bpd3K7bHH0bY9vKGGwZDDjcIVifmGpZTDjc5Jz\WyjdHXkJJdqfGhiR{KtUUBxcGG|ZTDhdpJme3R? NIW4co4yOjR7MkGxOy=>
U266 M{CyNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTqcHU2ODBibnevcYw> NILMV5M1QCCq NYTyUJJbTE2VTx?= NIW4dGpKdmirYnn0d{Bk\WyuIHfyc5d1cA>? NWPNbYtROTJ4M{G2NVk>
ARH77 MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zLWlUxOCCwZz;tcC=> MmXQOFghcA>? NFWwcoRFVVOR MVfJcohq[mm2czDj[YxtKGe{b4f0bC=> MXGxNlY{OTZzOR?=
WAD-1 M1L1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvpSG1GPTByIH7nM41t NWjPRYFmPDhiaB?= NXLkUJFYTE2VTx?= MlPrTY5pcWKrdIOgZ4VtdCCpcn;3eIg> NYfhe|NvOTJ4M{G2NVk>
U266/LR7 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;YXnQzPTByIH7nM41t NWnFWlRtPDhiaB?= Mo\ySG1UVw>? M2W2O2lvcGmkaYTzJINmdGxiZ4Lve5Rp NFLMNYoyOjZ|MU[xPS=>
U266/dox4 NYXIRZRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[0NVUxOCCwZz;tcC=> MmL5OFghcA>? M4iyUmROW09? NInNcYFKdmirYnn0d{Bk\WyuIHfyc5d1cA>? NX;SUpdOOTJ4M{G2NVk>
RPMI8226/LR5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HGRlUxOCCwZz;tcC=> NWrZTVViPDhiaB?= Ml7PSG1UVw>? NIXnO4xKdmirYnn0d{Bk\WyuIHfyc5d1cA>? MVmxNlY{OTZzOR?=
H460 M37mNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLtNVAh|ryP NXrQNnhLPzJiaB?= NULyT2N3TE2VTx?= NGnRVplKSzVyPUGwNEBvVQ>? NX\0VodYOTJ4M{G2NlA>
H358 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWmxNEDPxE1? NGXkUGU4OiCq M2fRXmROW09? MXvJR|UxRTdyIH7N NFW1VWcyOjZ|MU[yNC=>
H322 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvZNVAh|ryP Mm\nO|IhcA>? M1vMcWROW09? MoHmTWM2OD14MkCgcm0> MVSxNlY{OTZ{MB?=
H460 NIjhe3RHfW6ldHnvckBCe3OjeR?= M2nOXFExOCCwTR?= M{nUTFI1KGh? MV7EUXNQ M1ny[Wlv\HWlZYOgS|IuVS2yaHHz[UBienKnc4SgZY5lKHS3YoXsbY4h[XO|ZX3icJku\Gm|YYPz[Y1jdHl? NHjTfFQyOjZ|MU[yNC=>
LNCap-Pro5 NFzkXZdHfW6ldHnvckBCe3OjeR?= NHvGfWwyKM7:TR?= NW\lNo0xPCCq MV\EUXNQ MWfTeIFjcWyrenXzJJA2Ow>? NFrpVWIyPDZzMkWzNi=>
T29 NIn6R4ZCeG:ydH;zbZMhSXO|YYm= MnrqOVAhdk1? MnL4OFghcCB? MnXhSG1UVw>? MnXWTY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? NXjmbndjOTZ5N{ixO|k>
T29Kt1 MV7BdI9xfG:|aYOgRZN{[Xl? NGnl[o82OCCwTR?= MlLhOFghcCB? NWHPVZFMTE2VTx?= MnPETY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? MoPNNVY4PzhzN{m=
HCT116 MUTBdI9xfG:|aYOgRZN{[Xl? M4\uRlUxKG6P NXrGVWY6PDhiaDC= MlPYSG1UVw>? NGHreHdKdmS3Y3XzJINmdGxiYYDvdJRwe2m| NYHVcGlzOTZ5N{ixO|k>
HKe-3 M2fIdWFxd3C2b4Ppd{BCe3OjeR?= M2fYfVUxKG6P M1Pue|Q5KGhi MoHJSG1UVw>? MUDJcoR2[2W|IHPlcIwh[XCxcITvd4l{ NFLVfYgyPjd5OEG3PS=>
NB-1691 NFT5[HVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVqxJO69VQ>? MWK3NkBp M4GxVmlvcGmkaYTzJINmdGxicILvcIln\XKjdHnvckB1dyB3JR?= Mk\uNVc3QDl4OES=
CHLA-255 NYjGNlY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DX[FEh|ryP M1;HflczKGh? MkTiTY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJJRwKDJn M3K5eVE4Pjh7Nki0
SK-N-AS M4fyNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf6VJJ5OSEQvF2= M37IU|czKGh? NV;XZXlJUW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKHSxIEGwKS=> NYrQVIlROTd4OEm2PFQ>
NB-1691 MVzGeY5kfGmxbjDBd5NigQ>? NGTFboQyOCCwTR?= MmC4NlQhcA>? M4XMVHNq\26rZnnjZY51dHlicnXkeYNmeyClZXzsd{BqdiC2aHWgS|AwTzFicHjhd4U> NHfCW24yPzZ6OU[4OC=>
CHLA-255 NVXpUotvTnWwY4Tpc44hSXO|YYm= NHHOTFkyOCCwTR?= NY\SeZJJOjRiaB?= NGHP[XhOd2Snc4TsfUBz\WS3Y3XzJINmdGy|IHnuJJRp\SCJMD;HNUBxcGG|ZR?= MlHkNVc3QDl4OES=
RPMI 8226 NHjYRmZHfW6ldHnvckBCe3OjeR?= M3\yZ|IxKG6P MXe4JIg> NX22boRPW2mpbnnmbYNidnSueTDlcohidmOnczDOSk3PwkJiYXP0bZZqfHl? NHXvO4syQTR|NkC1NC=>
MM.1S Mkm4SpVv[3Srb36gRZN{[Xl? MlrCNlAhdk1? NVjVbnZNQCCq MXjTbYdvcW[rY3HueIx6KGWwaHHuZ4V{KE6ILd86RkBi[3Srdnn0fS=> M2rsOFE6PDN4MEWw
U266 MWjGeY5kfGmxbjDBd5NigQ>? MUSyNEBvVQ>? M3;IUVghcA>? MW\TbYdvcW[rY3HueIx6KGWwaHHuZ4V{KE6ILd86RkBi[3Srdnn0fS=> NFrqepcyQTR|NkC1NC=>
OPM1 M4O1V2Z2dmO2aX;uJGF{e2G7 NFLKZ|IzOCCwTR?= NFzoOG45KGh? MWnTbYdvcW[rY3HueIx6KGWwaHHuZ4V{KE6ILd86RkBi[3Srdnn0fS=> Ml7VNVk1OzZyNUC=
INA6 M{O4cWZ2dmO2aX;uJGF{e2G7 M2XifFIxKG6P MYC4JIg> MmDPV4lodmmoaXPhcpRtgSCnbnjhcoNmeyCQRj5OvmIh[WO2aY\peJk> M17jWVE6PDN4MEWw
OPM2 MonaSpVv[3Srb36gRZN{[Xl? NGjnTXIzOCCwTR?= NYnFbW1CQCCq NHTaUXVUcWewaX\pZ4FvfGy7IHXubIFv[2W|IF7GMe67SiCjY4Tpeol1gQ>? MnnYNVk1OzZyNUC=
RPMI 8226 NUPVNmp[TnWwY4Tpc44hSXO|YYm= M3\tOFIxKG6P M4XaVVghcA>? MYjJcoR2[2W|IFTORUB{gW62aHXzbZM> NH71T3AyQTR|NkC1NC=>
BaF/3 M3XjfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zDTVExOCCwTR?= MoPFOFghcA>? NYTWV4tHUUN3ME22MlIhdk1? MkLvNlA{ODV4OUK=
BaF/3-p210 NHvjPWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNFAhdk1? NH[3XWE1QCCq MoTmTWM2OD12Lkegcm0> NETQfm0zODNyNU[5Ni=>
TCC-S NWTJd5NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXixNFAhdk1? MUi0PEBp MnzVTWM2OD1{Lkigcm0> MUKyNFMxPTZ7Mh?=
BaF/3 MY\GeY5kfGmxbjDBd5NigQ>? M1H5OVYhdk1? NV3aeGJzPDhiaB?= NWX5NmcxUW6mdXPld{BiKGe{ZXH0JGcyKGOnbHytZ5lkdGViYYLy[ZN1 M4Pn[VIxOzB3Nkmy
BaF/3-p210 NF3DOJNHfW6ldHnvckBCe3OjeR?= NUfHcpVPPiCwTR?= M4PvfVQ5KGh? M2fGRmlv\HWlZYOgZUB{dGmpaISgS|Eh[2WubD3jfYNt\SCjcoLld5Q> NUTaVZo6OjB|MEW2PVI>
BaF/3-p210 M{\JPWZ2dmO2aX;uJGF{e2G7 MUS2JI5O M4mxVFI1KGh? M4XpWXJm\HWlZYOgeIhmKHCqb4PwbI9zgWyjdHnvckBidmRidHjlJIFkfGm4aYT5JI9nKFKk M2KySVIxOzB3Nkmy
Raji M1XCT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXxOHpNOSEQvF2= NH20e|YzPCCq M{S1fXJm\HWlZYOgZ4VtdCC4aXHibYxqfHoEoB?= MVqyNVE4ODl6OB?=
LCL-1 MlXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDrNUDPxE1? NGLRXIMzPCCq MomyVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi MoXxNlEyPzB7OEi=
LCL-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH3U|QyKM7:TR?= M2jOXVI1KGh? MYrS[YR2[2W|IHPlcIwhfmmjYnnsbZR6yqB? MnPkNlEyPzB7OEi=
BJAB NG\abXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXKxJO69VQ>? MUSyOEBp NWDad5E5WmWmdXPld{Bk\WyuII\pZYJqdGm2edMg MYqyNVE4ODl6OB?=
SNT-13 NGrkdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PVXFEh|ryP MmnoNlQhcA>? Mo\tVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi NGDvSGQzOTF5MEm4PC=>
SNT-16 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;oW|Eh|ryP MWSyOEBp NEC1S3hT\WS3Y3XzJINmdGxidnnhZoltcXS7wrC= NF7zRVkzOTF5MEm4PC=>
Jurkat M3SzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHHUIUyKM7:TR?= NGPKdIUzPCCq M4foUXJm\HWlZYOgZ4VtdCC4aXHibYxqfHoEoB?= NW\G[mZsOjFzN{C5PFg>
KAI-3 NIPOd2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[0PFEh|ryP MWOyOEBp M4LvO3Jm\HWlZYOgZ4VtdCC4aXHibYxqfHoEoB?= NYfLeIxROjFzN{C5PFg>
SNK-6 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rMXVEh|ryP NI[xUXgzPCCq MU\S[YR2[2W|IHPlcIwhfmmjYnnsbZR6yqB? M1LQSVIyOTdyOUi4
KHYG-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojiNUDPxE1? MX[yOEBp NGjCS|NT\WS3Y3XzJINmdGxidnnhZoltcXS7wrC= NWq1eIZNOjFzN{C5PFg>
SNT-16 MkW5RZBweHSxc3nzJGF{e2G7 MWGxJO69VQ>? MmqzOkBp NVviXFBmUW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= M1[1S|IyOTdyOUi4
Jurkat MnrxRZBweHSxc3nzJGF{e2G7 NUXL[olqOSEQvF2= M3HYelYhcA>? NYm0XYVuUW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= M4LweVIyOTdyOUi4
KAI-3 MknURZBweHSxc3nzJGF{e2G7 NWW1bHVLOSEQvF2= NG[wbWQ3KGh? M1v3NWlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? NHziS2wzOTF5MEm4PC=>
KHYG-1 MXrBdI9xfG:|aYOgRZN{[Xl? MUCxJO69VQ>? NXT2PVJzPiCq MY\JcoR2[2W|IHPlcIwh[XCxcITvd4l{ NVPmN3B1OjFzN{C5PFg>
SNT-13 MkTwRY51cX[rcnHsJGF{e2G7 NXfldINmOSEQvF2= MYGyOEBp NHLkVYFKdmS3Y3XzJIx6fGmlIHnu[oVkfGmxbjDv[kBGSlZ? M4\ReFIyOTdyOUi4
SNT-16 M1:4eGFvfGm4aYLhcEBCe3OjeR?= NHzwW4UyKM7:TR?= NGHHV5IzPCCq MlrHTY5lfWOnczDsfZRq[yCrbn\lZ5Rqd25ib3[gSWJX M{\0ZVIyOTdyOUi4
KAI-3 NFHOO2ZCdnSrdnnyZYwhSXO|YYm= MXOxJO69VQ>? MnrPNlQhcA>? NXeyOItjUW6mdXPld{BtgXSrYzDpcoZm[3Srb36gc4YhTUKY NHXFboEzOTF5MEm4PC=>
SNK-6 MoXtRY51cX[rcnHsJGF{e2G7 NEnqXGoyKM7:TR?= M4TrV|I1KGh? NY\tR5ltUW6mdXPld{BtgXSrYzDpcoZm[3Srb36gc4YhTUKY NHzmfIczOTF5MEm4PC=>
RAW 264.7 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\1OXdnOTByIH7N NWP2To5LPDhiaB?= MnTRVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi MmPoNlI1OjdzNUS=
A375 NHT2VYlCeG:ydH;zbZMhSXO|YYm= NHjJO4kyOCCwTR?= M4GwZlI1KGh? NGjFNGNKdmS3Y3XzJINmdGxiYYDvdJRwe2m| NWnRRWdEOjNyN{mwPFM>
BLM NW\UOHRNSXCxcITvd4l{KEG|c3H5 M3LlcVExKG6P NX;DT4FFOjRiaB?= MWfJcoR2[2W|IHPlcIwh[XCxcITvd4l{ M{i0fFI{ODd7MEiz
A375 M175NmF2fG:yaHHnfUBCe3OjeR?= NYDHeIJKOTBibl2= NF7NcI4yOiCq NVf6V4dLUW6mdXPld{Bnd3KvYYTpc44hd2ZiYYX0c5Bp[Wexc3;t[ZM> MoP4NlMxPzlyOEO=
BLM MlPsRZV1d3CqYXf5JGF{e2G7 MUCxNEBvVQ>? NIW2Z2QyOiCq MlfwTY5lfWOnczDmc5Ju[XSrb36gc4Yh[XW2b4DoZYdwe2:vZYO= NGLQeYgzOzB5OUC4Ny=>
H1299 MoT5RZBweHSxc3nzJGF{e2G7 MoDiPFAhdk1? NHL0UpkzPCCq NIDTdHFFVVOR MkH5V4Vve2m2aYrld{BPW0OOQzDj[YxteyC2bzDNV2Mu\GW{aY\l[EBqSzlvaX7keYNm\CCjcH;weI9{cXN? MViyOVMzOzZ7Mx?=
Hut-78 MnLWSpVv[3Srb36gRZN{[Xl? NX3K[VRYOTByIH7N MXKyOEBp NUW2bGZKTE2VTx?= NIDI[IdFd3ewcnXneYxifGW|IGTHSk3PujFiYX7kJGlNNTFyIHX4dJJme3Orb36= MXmyOVY5OTN|NR?=
H9 NGftRo1HfW6ldHnvckBCe3OjeR?= MX[xNFAhdk1? MnP3NlQhcA>? NFnnemRFVVOR NFPEXFFFd3ewcnXneYxifGW|IGTHSk3PujFiYX7kJGlNNTFzIHX4dJJme3Orb36= MmmzNlU3QDF|M{W=
HH NIOxWXlHfW6ldHnvckBCe3OjeR?= MmjqNVAxKG6P M1n6[lI1KGh? MX\EUXNQ MWDkc5dvemWpdXzheIV{KFSJRj5OtlEh[W6mIFnMMVEzKGW6cILld5Nqd25? NHjMOHkzPTZ6MUOzOS=>
Hut-78 NUOwNnRiVWmpcnH0bY9vKEG|c3H5 NHnY[XYyODBibl2= M4nZTlI1KGh? M33iXmROW09? MXzS[YR2[2W|IHPlcIwhdWmpcnH0bY9vKGK7IEiw5qCUQTBn NIn0OnkzPTZ6MUOzOS=>
HH M4jk[21q\3KjdHnvckBCe3OjeR?= NVrrWnp4OTByIH7N NUHyPZpXOjRiaB?= NH;tVFFFVVOR M3m1NXJm\HWlZYOgZ4VtdCCvaXfyZZRqd25iYomgPFDjiJN7MTW= NXPWd|BsOjV4OEGzN|U>
U937 M2m3b2Z2dmO2aX;uJGF{e2G7 MYCxNFAhdk1? M3P2OlYhcA>? MVvJcoR2[2W|IFnMMVgh\XiycnXzd4lwdiCrbjDMVHMue3SrbYXsZZRm\CCXOUO3JI1i[3KxcHjh[4V{ NYSwV3lEOjV5OUG0O|c>
human PBMC NF7mZmNHfW6ldHnvckBCe3OjeR?= NU[4VGYyOTByIH7N NIXkfI0zPCCq NYPoZVVXUW6mdXPld{BKVC16IILlcIVie2V? NUPqXXVXOjV5OUG0O|c>
ES6 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfoUmlKSzVyPUCuNFAzOSCwTR?= M2PGT3NCVkeHUh?=
SK-UT-1 M3GwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMU[zJI5O MV;TRW5ITVJ?
SH-4 NUfzNlFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDTTWM2OD1yLkG3N{BvVQ>? MVzTRW5ITVJ?
TE-9 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPpR41uUUN3ME2wMlE5OiCwTR?= NF:zWnBUSU6JRWK=
A253 NXSzTWxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[3V2dKSzVyPUCuNlA5KG6P M3nxb3NCVkeHUh?=
no-10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i0WWlEPTB;MD6yNUBvVQ>? MXHTRW5ITVJ?
MMAC-SF MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2m5dmlEPTB;MD6yNVYhdk1? MYDTRW5ITVJ?
A101D MkPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMkK1JI5O MnywV2FPT0WU
NTERA-S-cl-D1 M4fTZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlflTWM2OD1yLkK0N{BvVQ>? NYfoeJlvW0GQR1XS
8-MG-BA MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMkWgcm0> MoHuV2FPT0WU
KNS-42 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMkW4JI5O M364W3NCVkeHUh?=
LXF-289 NWD2NnVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMk[5JI5O MnWzV2FPT0WU
OVCAR-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13EfmlEPTB;MD6yPFkhdk1? MlG5V2FPT0WU
LOUCY NYWyfFFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmW4TWM2OD1yLkK5N{BvVQ>? M1\vTXNCVkeHUh?=
BB65-RCC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC0eHdVUUN3ME2wMlMxPCCwTR?= M4jpbHNCVkeHUh?=
D-542MG M2exdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37Xd2lEPTB;MD6zNlkhdk1? Mn3xV2FPT0WU
ONS-76 NITscmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj2SHJ[UUN3ME2wMlM{KG6P MnzPV2FPT0WU
BB30-HNC MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHGTWM2OD1yLkOzOUBvVQ>? NYK5S25WW0GQR1XS
KS-1 NVjvSHdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17ZTmlEPTB;MD6zOEBvVQ>? NWXBOZhKW0GQR1XS
A388 Ml7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTmeY9KSzVyPUCuN|U3KG6P Ml3FV2FPT0WU
ES8 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjP[GhWUUN3ME2wMlQhdk1? MXPTRW5ITVJ?
MZ2-MEL MnPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwNEC3JI5O NG\LSlFUSU6JRWK=
HCC2998 M2O2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7DZ5VKSzVyPUCuOFEzKG6P MlzYV2FPT0WU
D-247MG NI[1eHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\4TWM2OD1yLkSxN{BvVQ>? NUDkcldnW0GQR1XS
ACN NXywXoRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG1TWM2OD1yLkSxO{BvVQ>? MlXXV2FPT0WU
LB2518-MEL M4qwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHCOplmUUN3ME2wMlQzPSCwTR?= MXrTRW5ITVJ?
ES1 NVntcYhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\RPWlEPTB;MD60N{BvVQ>? MVzTRW5ITVJ?
HCE-T MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NECyUHlKSzVyPUCuOFM6KG6P MWjTRW5ITVJ?
OS-RC-2 MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUC2O3J5UUN3ME2wMlQ1KG6P MlTTV2FPT0WU
MFH-ino Mkj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwNESzJI5O NF[5S2pUSU6JRWK=
OCUB-M NIjjdnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTDTWM2OD1yLkS0O{BvVQ>? MUnTRW5ITVJ?
CP66-MEL NVThZXFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;jTWM2OD1yLkS3N{BvVQ>? NYHXVoN6W0GQR1XS
LB771-HNC NVTpNmtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTaTWM2OD1yLkS3OEBvVQ>? M3TINHNCVkeHUh?=
DSH1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwNEigcm0> MnvlV2FPT0WU
HUTU-80 MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLFN|hmUUN3ME2wMlU{OyCwTR?= M1[1enNCVkeHUh?=
CESS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj3[oVXUUN3ME2wMlU{QCCwTR?= M{XqR3NCVkeHUh?=
NCI-H747 NYfVbmR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLueZBVUUN3ME2wMlU{QSCwTR?= NVXYVHhTW0GQR1XS
HT-144 M2myPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwNUe2JI5O MYDTRW5ITVJ?
COLO-829 NGTzTpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvvXoJKSzVyPUCuOlE1KG6P NHvGZZVUSU6JRWK=
A4-Fuk MoThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwNkKzJI5O NE\hNFdUSU6JRWK=
GI-ME-N NVXiUY5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoSwTWM2OD1yLk[zOEBvVQ>? NYP6dpRoW0GQR1XS
LB831-BLC NHTDSm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O2NWlEPTB;MD62OFEhdk1? Ml\KV2FPT0WU
HOP-62 Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4qzWGlEPTB;MD62OFchdk1? MWjTRW5ITVJ?
BB49-HNC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwNkWyJI5O NFn5SHpUSU6JRWK=
D-336MG NU\sXoRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3qeppKSzVyPUCuOlU4KG6P MmTXV2FPT0WU
TK10 NIf2WZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwNke5JI5O MofEV2FPT0WU
Ramos-2G6-4C10 NUPReoNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;JNGJKSzVyPUCuOlk{KG6P NHvMPVNUSU6JRWK=
LB373-MEL-D MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwNzDuUS=> MUnTRW5ITVJ?
SF126 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3ZZ4hKSzVyPUCuO|AyKG6P MWTTRW5ITVJ?
UACC-257 NYTJd3VWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF31O|dKSzVyPUCuO|Ehdk1? M2L3XnNCVkeHUh?=
KINGS-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPPe3k4UUN3ME2wMlczOiCwTR?= MY\TRW5ITVJ?
LS-513 MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPFOGFKSzVyPUCuO|M6KG6P MX7TRW5ITVJ?
GI-1 NY\udYdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfZT5VKSzVyPUCuO|Y1KG6P NVTLN2tKW0GQR1XS
ES7 M2fHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH74dnVKSzVyPUCuO|Y3KG6P MmPEV2FPT0WU
LB2241-RCC MmXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwOEC0JI5O Ml\oV2FPT0WU
D-263MG NH\R[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n5dmlEPTB;MD64NFchdk1? MX\TRW5ITVJ?
SW684 M3L3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7LTWM2OD1yLkiyNUBvVQ>? M3z1UnNCVkeHUh?=
ML-2 M3fxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzF[XhKSzVyPUCuPFIyKG6P MYfTRW5ITVJ?
SK-LMS-1 MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrhOotjUUN3ME2wMlg2PCCwTR?= MojHV2FPT0WU
TE-5 NE\PZlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHYTWM2OD1yLki2OUBvVQ>? NWHvXmFDW0GQR1XS
QIMR-WIL MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwOEi5JI5O NELOempUSU6JRWK=
NCI-H1355 MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rQXmlEPTB;MD64PVUhdk1? NXPVO4FnW0GQR1XS
SNB75 M173Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz5V|ZKSzVyPUCuPVEzKG6P MoHKV2FPT0WU
RXF393 NHi5W3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHoVVdiUUN3ME2wMlkyPCCwTR?= MnHBV2FPT0WU
IST-MEL1 NHKyVXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGP5Z2tKSzVyPUCuPVE4KG6P M{nJTXNCVkeHUh?=
SF268 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwOUKzJI5O NFTv[4RUSU6JRWK=
KALS-1 M4HmOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXBTWM2OD1yLkmyOUBvVQ>? NUPNelJDW0GQR1XS
HC-1 NGez[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:5TWM2OD1yLkm3OUBvVQ>? MULTRW5ITVJ?
SW872 NIjX[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPZTWM2OD1yLkm5OkBvVQ>? NFrIR21USU6JRWK=
PSN1 Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFwMEGgcm0> NUXVdpM1W0GQR1XS
TE-1 NUHZTolvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33wZWlEPTB;MT6wN{BvVQ>? MUDTRW5ITVJ?
TE-10 M3L5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPtXHBKSzVyPUGuNFMhdk1? MUXTRW5ITVJ?
RKO MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnTN3E6UUN3ME2xMlA3KG6P MlTUV2FPT0WU
LC-2-ad M3vRXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnTW|NKSzVyPUGuNFghdk1? NHT1cHJUSU6JRWK=
SK-MM-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7OS4ZKSzVyPUGuNFkhdk1? Mn7EV2FPT0WU
VA-ES-BJ NUC2O5RUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTFwMEmgcm0> NXPZd4E4W0GQR1XS
MZ7-mel MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknyTWM2OD1zLkC5JI5O MmP0V2FPT0WU
D-392MG Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnkdpBWUUN3ME2xMlEhdk1? MoLjV2FPT0WU
CCRF-CEM NFzXTGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHsTWM2OD1zLkGzJI5O MlvTV2FPT0WU
EM-2 NVf4XVBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLPTWM2OD1zLkG2JI5O MVTTRW5ITVJ?
HAL-01 NXX6R2dzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPBcpVKSzVyPUGuNVghdk1? MmHxV2FPT0WU
TE-8 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{iySWlEPTB;MT6xPUBvVQ>? NE\jT3pUSU6JRWK=
NCI-H1882 NXrFUGpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rpUmlEPTB;MT6yJI5O NIjWfFJUSU6JRWK=
Daudi MnLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFwMkKgcm0> MVfTRW5ITVJ?
BL-41 M4PIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPDeppyUUN3ME2xMlI2KG6P MWDTRW5ITVJ?
SR MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LYO2lEPTB;MT6yOUBvVQ>? M360O3NCVkeHUh?=
KM12 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jMSGlEPTB;MT6yO{BvVQ>? M4LMXXNCVkeHUh?=
K5 M3PXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPrS5pKSzVyPUGuNlghdk1? MWnTRW5ITVJ?
A3-KAW MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\DeGtQUUN3ME2xMlI5KG6P NYeyRWV{W0GQR1XS
CMK MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfp[HlKSzVyPUGuNlkhdk1? MnPzV2FPT0WU
Calu-6 MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LzbWlEPTB;MT6yPUBvVQ>? MV3TRW5ITVJ?
IST-SL2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XEVWlEPTB;MT6zNUBvVQ>? NGXwUJdUSU6JRWK=
OPM-2 NWm1SJhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTFwM{Ogcm0> NWTqd4R2W0GQR1XS
DU-4475 NUXtXJlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjPb2E{UUN3ME2xMlM3KG6P NGjHSlVUSU6JRWK=
ECC12 MlTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTFwM{egcm0> MnzJV2FPT0WU
L-540 NFrY[5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTFwM{egcm0> M1rzO3NCVkeHUh?=
CAS-1 NYfGV4R2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrNXXRuUUN3ME2xMlM4KG6P MorVV2FPT0WU
PF-382 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUThd3VJUUN3ME2xMlQ4KG6P NXfLbnlDW0GQR1XS
LS-411N M3XZb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDOZm9KSzVyPUGuOVMhdk1? NXfTb2luW0GQR1XS
NCI-H69 M3jXemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:1[mlEPTB;MT61OEBvVQ>? NYnHd5NyW0GQR1XS
NB12 NUizbW9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTFwNU[gcm0> M1X2eHNCVkeHUh?=
HEL NVW4emE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fMbmlEPTB;MT62NUBvVQ>? MmHJV2FPT0WU
GCIY Mn7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwNkKgcm0> MUnTRW5ITVJ?
EHEB NIDuSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrre5RKSzVyPUGuOlchdk1? NGKxeo5USU6JRWK=
TGBC1TKB NXvid48yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTJfINwUUN3ME2xMlcyKG6P MoriV2FPT0WU
KURAMOCHI NX7pdXBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHCZVhuUUN3ME2xMlczKG6P NYXJT29oW0GQR1XS
U-266 M3K5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFwN{[gcm0> NGSwTYlUSU6JRWK=
LC4-1 NEHHVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLReGpRUUN3ME2xMlc6KG6P M3LSfXNCVkeHUh?=
NCI-H2126 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFwODDuUS=> NIL4UXJUSU6JRWK=
NCI-H1092 NFTVZpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrrPXVKSzVyPUGuPEBvVQ>? MXLTRW5ITVJ?
GB-1 NUPqN3ppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTFwOEGgcm0> MofLV2FPT0WU
MV-4-11 NEXVW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrKTWM2OD1zLkiyJI5O MYnTRW5ITVJ?
Becker NILOXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrpUGtDUUN3ME2xMlg{KG6P MYfTRW5ITVJ?
MPP-89 NUjzc3hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULwd3Y3UUN3ME2xMlg6KG6P MV\TRW5ITVJ?
BE-13 NXXjeItoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz1W3hwUUN3ME2xMlk{KG6P MlvlV2FPT0WU
697 NGG0[YdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLzTWM2OD1zLkm5JI5O M3TtUXNCVkeHUh?=
NKM-1 Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fBcGlEPTB;MjDuUS=> NW[0So5iW0GQR1XS
NB13 NXnlNWlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXjWIRKSzVyPUKgcm0> NFL2fZlUSU6JRWK=
LS-123 M3TEdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnVTWM2OD1{LkCyJI5O MV;TRW5ITVJ?
NB17 NXXaPVlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrVcGVWUUN3ME2yMlA1KG6P NUHSW3o6W0GQR1XS
LAN-6 NWXzdXJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJwMEWgcm0> MYfTRW5ITVJ?
EW-24 NGWxO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDlTWM2OD1{LkC4JI5O MY\TRW5ITVJ?
NOS-1 NWP1S5c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJwMUGgcm0> MUHTRW5ITVJ?
BL-70 M4f2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3Qe4RKSzVyPUKuNVIhdk1? M2P6XnNCVkeHUh?=
GT3TKB NGraTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLyTWM2OD1{LkGyJI5O Ml[xV2FPT0WU
HH MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP6OVVKSzVyPUKuNVMhdk1? MVrTRW5ITVJ?
KE-37 NWXYXogzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwMUOgcm0> NXPWfWhkW0GQR1XS
MOLT-4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXqdGhKSzVyPUKuNVMhdk1? MljCV2FPT0WU
EKVX MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf6OHJKSzVyPUKuNVQhdk1? MY\TRW5ITVJ?
KGN MlXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PJdGlEPTB;Mj6xOUBvVQ>? MUPTRW5ITVJ?
ES4 NEnyOJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJwMU[gcm0> MmK0V2FPT0WU
SJSA-1 M3jiO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XEOWlEPTB;Mj6yNUBvVQ>? NVXVWZk1W0GQR1XS
KMOE-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S2emlEPTB;Mj6yN{BvVQ>? NFrFV2lUSU6JRWK=
NB5 NVXyXHJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fXUmlEPTB;Mj6yO{BvVQ>? MmDnV2FPT0WU
BC-1 NIG2e4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjPSoFKSzVyPUKuN|Ehdk1? NYTQU45sW0GQR1XS
NB10 NXr2b5h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2SzNWlEPTB;Mj6zNkBvVQ>? NGjRUJhUSU6JRWK=
RPMI-8226 Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnKW3dKSzVyPUKuN|Uhdk1? NF3yfJlUSU6JRWK=
SCC-3 MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H1UWlEPTB;Mj6zO{BvVQ>? MnL4V2FPT0WU
ARH-77 NXe0W4JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Lu[mlEPTB;Mj6zPEBvVQ>? NYfnU|kyW0GQR1XS
NCI-H748 MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJwM{mgcm0> NHrob25USU6JRWK=
KU812 NHHvTYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T6PWlEPTB;Mj60NkBvVQ>? NULtXGM6W0GQR1XS
NCI-H64 Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJwNESgcm0> MUjTRW5ITVJ?
NB69 NX7UZok2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPj[2lKSzVyPUKuOFYhdk1? NU[xe5R1W0GQR1XS
KNS-81-FD MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJwNEigcm0> NGLZdFdUSU6JRWK=
LB1047-RCC M3Gxbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjVTWM2OD1{LkW3JI5O MmSwV2FPT0WU
EB-3 NVvjN5N{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfHb2JKSzVyPUKuOlYhdk1? MVrTRW5ITVJ?
Mo-T MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrN[FhNUUN3ME2yMlc1KG6P NVuxS|FkW0GQR1XS
EW-16 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj1WGlKSzVyPUKuO|Uhdk1? M2HGeHNCVkeHUh?=
CTV-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fFNmlEPTB;Mj64JI5O MljDV2FPT0WU
ETK-1 M2HESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfFc5h[UUN3ME2yMlg1KG6P Mk\XV2FPT0WU
C2BBe1 NGGweHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPoTWM2OD1{Lki5JI5O NVe3THE2W0GQR1XS
MOLT-16 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\sUJYyUUN3ME2yMlg6KG6P NHn0PHJUSU6JRWK=
SW954 M{jvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NESxRYNKSzVyPUKuPUBvVQ>? Mle2V2FPT0WU
HT M4fOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTNwMEKgcm0> NVvOdXRnW0GQR1XS
KARPAS-299 MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe4VZlRUUN3ME2zMlA3KG6P Ml:4V2FPT0WU
MONO-MAC-6 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vwfWlEPTB;Mz6xJI5O M2XycHNCVkeHUh?=
CGTH-W-1 Ml3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTNwMTDuUS=> MX7TRW5ITVJ?
SK-PN-DW MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjRWFRKSzVyPUOuNVQhdk1? NX3POItYW0GQR1XS
CW-2 NGrOeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX5[lRKSzVyPUOuNlEhdk1? M{DIeHNCVkeHUh?=
SK-N-DZ MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:3[HRKSzVyPUOuNlYhdk1? M{Ptb3NCVkeHUh?=
NEC8 NWfEO2dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33PWGlEPTB;Mz6zOUBvVQ>? NIjt[2FUSU6JRWK=
LB996-RCC NVP5eWlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXnSVZrUUN3ME2zMlQhdk1? MX\TRW5ITVJ?
DB NVvsU5ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO4TWM2OD1|LkSxJI5O MXzTRW5ITVJ?
TE-15 M{W1fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HIcmlEPTB;Mz60N{BvVQ>? MXHTRW5ITVJ?
COR-L88 M{nib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m4W2lEPTB;Mz60O{BvVQ>? MWPTRW5ITVJ?
LAMA-84 NWTNZ4luT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrUTWM2OD1|LkS5JI5O M3vObnNCVkeHUh?=
MEG-01 NFPNRmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHKeVF3UUN3ME2zMlQ6KG6P NVHnPWU1W0GQR1XS
LOXIMVI NHHG[m1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[5W5ZKSzVyPUOuOUBvVQ>? M1XpeHNCVkeHUh?=
RPMI-8402 M4\Hd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlSwTWM2OD1|LkWgcm0> M3nuSXNCVkeHUh?=
KARPAS-45 NYrOcYxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTNwNUSgcm0> M1XkRXNCVkeHUh?=
HCC1187 M3\5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTNwNUSgcm0> NETLNmRUSU6JRWK=
MZ1-PC NYjNTVR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PWdWlEPTB;Mz61OEBvVQ>? Mm\yV2FPT0WU
no-11 M{nBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDTTWM2OD1|LkW1JI5O NFLrPIpUSU6JRWK=
EVSA-T NFPIVHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzpNG5sUUN3ME2zMlYhdk1? NH74e4JUSU6JRWK=
DJM-1 NFzIVZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP0VW9UUUN3ME2zMlY{KG6P NEnnTpBUSU6JRWK=
COLO-684 NF7QPGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrXTWM2OD1|Lk[2JI5O NVPjdXNUW0GQR1XS
NMC-G1 NEDpXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHLNoN3UUN3ME2zMlY5KG6P NFzQZ4FUSU6JRWK=
LC-1F Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTNwN{Sgcm0> NILzdIVUSU6JRWK=
RL95-2 Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fYZ2lEPTB;Mz63PUBvVQ>? MoLxV2FPT0WU
COLO-320-HSR MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXMWYdwUUN3ME2zMlkzKG6P MXzTRW5ITVJ?
RCC10RGB MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPseFJZUUN3ME2zMlk{KG6P NWnIWYV3W0GQR1XS
HD-MY-Z NXvOdGhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;DTWM2OD1|LkmzJI5O MVvTRW5ITVJ?
NCI-H2141 Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULwenpuUUN3ME20MlA2KG6P MWHTRW5ITVJ?
K-562 MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvrTWM2OD12LkGyJI5O NIDCNppUSU6JRWK=
NCI-H1648 MomzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzXTWM2OD12LkGzJI5O M1Tt[nNCVkeHUh?=
OMC-1 NXX6[5d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XJTmlEPTB;ND6xPEBvVQ>? Ml;5V2FPT0WU
LB647-SCLC MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TIXGlEPTB;ND6yNkBvVQ>? M{LYSnNCVkeHUh?=
TE-12 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWxTWM2OD12LkK1JI5O Ml\mV2FPT0WU
NOMO-1 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkntTWM2OD12LkOzJI5O NFnId4JUSU6JRWK=
Raji Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH6zT25KSzVyPUSuOFYhdk1? M2DGVnNCVkeHUh?=
NALM-6 M1fpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nxV2lEPTB;ND60PUBvVQ>? MV7TRW5ITVJ?
HL-60 M2\yOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j2OmlEPTB;ND62O{BvVQ>? NX\4WYJRW0GQR1XS
IST-SL1 M{jLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PTb2lEPTB;ND62PEBvVQ>? NXn6ZVg3W0GQR1XS
MHH-PREB-1 NF3wdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTRwOE[gcm0> NGXveo5USU6JRWK=
MHH-NB-11 MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\zN2lEPTB;ND65NUBvVQ>? NX3sUnpzW0GQR1XS
JiyoyeP-2003 MljHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLqTWM2OD13IH7N Ml7pV2FPT0WU
SBC-1 M1LYPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\LeWlEPTB;NT6wNUBvVQ>? MUPTRW5ITVJ?
CHP-126 NF7rWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHkTWM2OD13LkC2JI5O Mn3HV2FPT0WU
LU-139 NXu3WYNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmm4TWM2OD13LkGzJI5O NETCS3hUSU6JRWK=
NCI-SNU-5 NH6z[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTVwMUegcm0> NGe3SGpUSU6JRWK=
SW962 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDjbY8zUUN3ME21MlIyKG6P NWnId5JkW0GQR1XS
EW-1 MofkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfIenNmUUN3ME21MlMyKG6P M2TxSXNCVkeHUh?=
NCI-H1417 M1Tudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\QNmlEPTB;NT61NUBvVQ>? NUHiO3hVW0GQR1XS
LU-65 M3LNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X4UGlEPTB;NT64OEBvVQ>? NIP6bmhUSU6JRWK=
D-502MG M3X5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjqW3NKSzVyPU[uN|chdk1? NXPTbWd3W0GQR1XS
BC-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTZwNkGgcm0> M{TtOXNCVkeHUh?=
GDM-1 M4rZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTZwN{egcm0> M2nQVXNCVkeHUh?=
NCI-H2196 MnL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne3TWM2OD14Lkigcm0> NVzXVotjW0GQR1XS
NB1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULR[Zo6UUN3ME22Mlg5KG6P MW\TRW5ITVJ?
NCI-H345 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ixcGlEPTB;Nz6yJI5O MWPTRW5ITVJ?
SU-DHL-1 M2rtVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfYR4dKSzVyPUeuNlQhdk1? NIHRRmpUSU6JRWK=
JVM-2 NYfIOGUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\WO2lEPTB;Nz6yPEBvVQ>? NUXiR3pwW0GQR1XS
LU-134-A NGXTbpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PaRWlEPTB;Nz6zPUBvVQ>? MmTEV2FPT0WU
NCI-H1694 NGnUUYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\vPIlKSzVyPUeuOVghdk1? M4PRenNCVkeHUh?=
NCI-SNU-16 MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvXXGpDUUN3ME23MlY2KG6P NGDWTlVUSU6JRWK=
L-363 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHWTWM2OD15Lkegcm0> MV3TRW5ITVJ?
KG-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\CNIQ3UUN3ME23Mlk1KG6P NFy0XJNUSU6JRWK=
MN-60 NYGydYd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:3UGlEPTB;OD6xOEBvVQ>? M1rWUnNCVkeHUh?=
NB6 NV3TRW13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm4XVdyUUN3ME24MlQ5KG6P MkTZV2FPT0WU
MLMA NYH1UHlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DuTmlEPTB;OD64OUBvVQ>? MUfTRW5ITVJ?
ATN-1 NUPTVYtCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nHd2lEPTB;OD64PUBvVQ>? NXTDO3pzW0GQR1XS
SK-NEP-1 NIjaT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;3R|VKSzVyPUmuNFEhdk1? NITsS5dUSU6JRWK=
DMS-114 M3rw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTlwNkKgcm0> M2PXN3NCVkeHUh?=
CTB-1 M{jCUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTlwNkegcm0> M3LjNnNCVkeHUh?=
NCI-H2081 M1TtWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfHboJKSzVyPUGwMlA6KG6P NIXvNIJUSU6JRWK=
ES5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL5TWM2OD1zMD6zPEBvVQ>? MmfvV2FPT0WU
HCC1599 M1vUd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rFXGlEPTB;MUGuPVEhdk1? MXXTRW5ITVJ?
NCI-H23 NEmy[5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTF{LkGyJI5O NYTWcYxqW0GQR1XS
NCI-H1581 NUH6[GNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXSV5hCUUN3ME2xNk4zQCCwTR?= NXXkeo02W0GQR1XS
JVM-3 NHvZ[nFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTF{Lkm5JI5O MWrTRW5ITVJ?
NCI-SNU-1 NXr6bWwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjofoFIUUN3ME2xN{4yQSCwTR?= NFfjWYlUSU6JRWK=
NB7 NYLCO5NWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVy0VHFlUUN3ME2xOU46OiCwTR?= NFHNbmFUSU6JRWK=
JAR NFfEOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTF4LkGzJI5O MoTyV2FPT0WU
TGW MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\kW3JKSzVyPUG2MlQ5KG6P MV\TRW5ITVJ?
U-87-MG M{PBZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf4UHRKSzVyPUG2Mlc3KG6P MmPsV2FPT0WU
NCI-H1436 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTF5LkCxJI5O M172cHNCVkeHUh?=
GOTO NUTnfG5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m0eGlEPTB;MUeuNFYhdk1? M2rtN3NCVkeHUh?=
COLO-800 NUnn[IN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTF5Lk[0JI5O MmTCV2FPT0WU
MFM-223 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHWTWM2OD1zNz65NUBvVQ>? NYnSVms2W0GQR1XS
EW-18 M{PTN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT4[21tUUN3ME2xO{46PiCwTR?= MkTtV2FPT0WU
NB14 NFi3V2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoC5TWM2OD1zNz65PEBvVQ>? NV7GNIJmW0GQR1XS
EB2 NEHleWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjQb3pzUUN3ME2xPE4xQCCwTR?= MYnTRW5ITVJ?
EoL-1- NX62[4VPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTF6LkOxJI5O MnrSV2FPT0WU
NCCIT NYO3ZWhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ThUWlEPTB;MUiuN|Yhdk1? NGnHPZlUSU6JRWK=
DG-75 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTF6Lk[xJI5O M3fxOHNCVkeHUh?=
HCC2218 NV\RZlhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LDVmlEPTB;MUmuOUBvVQ>? M2\mNXNCVkeHUh?=
TE-6 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fpXGlEPTB;MkCuNFghdk1? NHzDfVJUSU6JRWK=
SF539 MnfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moe4TWM2OD1{MD62O{BvVQ>? MYDTRW5ITVJ?
NCI-H446 NYnuS4V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\QRmhKSzVyPUKxMlE5KG6P NYTlUFlHW0GQR1XS
IST-MES1 NGf2PJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETHTIpKSzVyPUKyMlc4KG6P NUKyTplTW0GQR1XS
NCI-H82 M161Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXiTWM2OD1{Mz6wNkBvVQ>? NWrxe21KW0GQR1XS
HCC2157 NGLiNI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\uTWM2OD1{Mz6xN{BvVQ>? Ml\sV2FPT0WU
EW-12 M2LqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJ|LkG3JI5O MorFV2FPT0WU
SIMA M2KwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LLdGlEPTB;MkOuN|ghdk1? MV\TRW5ITVJ?
DOHH-2 NIHwc5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm3TWM2OD1{Mz60OUBvVQ>? NEfZfG9USU6JRWK=
IM-9 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJ|LkW0JI5O MkfyV2FPT0WU
EC-GI-10 NHSwbI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\DTWM2OD1{ND6yN{BvVQ>? NIS2NnRUSU6JRWK=
HDLM-2 NX\vRZNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjHc|huUUN3ME2yOE42PCCwTR?= NF20[ndUSU6JRWK=
LS-1034 NVLz[WJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHiU5BKUUN3ME2yOU44PSCwTR?= NYTTR3JMW0GQR1XS
REH MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjvb2hoUUN3ME2yOk41OSCwTR?= MnTGV2FPT0WU
LU-165 M4\xVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\yTWM2OD1{Nj63NkBvVQ>? M{XLcXNCVkeHUh?=
NH-12 NYOxUWNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDsTWM2OD1{Nz62O{BvVQ>? MkXqV2FPT0WU
WSU-NHL MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\sdZRIUUN3ME2yPE4{QSCwTR?= NX3OUpJqW0GQR1XS
ECC4 M37uemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7mTWM2OD1{OD63PUBvVQ>? M3nNPHNCVkeHUh?=
OCI-AML2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHM[oJWUUN3ME2yPU43QSCwTR?= NH3TWFhUSU6JRWK=
EW-3 NEPUW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXqTWM2OD1|MD61PUBvVQ>? NIj3Z4RUSU6JRWK=
NCI-H526 NX;RUVB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYqxSGN3UUN3ME2zNk42PCCwTR?= NXH1SZBYW0GQR1XS
NCI-H719 M1LmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPhRo5KUUN3ME2zOE4{OSCwTR?= MnviV2FPT0WU
KARPAS-422 M{TkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETK[VhKSzVyPUO1MlA1KG6P M1TnSnNCVkeHUh?=
SK-MEL-1 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;PSY1uUUN3ME2zOU4yPyCwTR?= M1qyfXNCVkeHUh?=
ES3 MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDvS3V5UUN3ME2zOU4yQSCwTR?= MV3TRW5ITVJ?
UACC-812 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnQXIFKSzVyPUO1MlQ1KG6P M2PMNnNCVkeHUh?=
C8166 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjNdmNwUUN3ME2zOU44KG6P M2TkcHNCVkeHUh?=
MDA-MB-134-VI NFjs[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTN3Lki3JI5O MYrTRW5ITVJ?
D-283MED NFfte5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP0TWM2OD1|Nz63PUBvVQ>? M1[wTnNCVkeHUh?=
SHP-77 NHnBcGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW3TWM2OD1|OD6wN{BvVQ>? NWX2Z4hJW0GQR1XS
NCI-H2227 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTRyLkS5JI5O NGK1cGZUSU6JRWK=
SKM-1 Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17GXmlEPTB;NEKuOlMhdk1? M3yzbXNCVkeHUh?=
L-428 Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37hbmlEPTB;NEOuPFYhdk1? NGnYe2RUSU6JRWK=
RPMI-6666 MmjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrNTWM2OD12NT64PUBvVQ>? M4XVdHNCVkeHUh?=
NCI-H716 M3fzdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XFU2lEPTB;NEiuPFEhdk1? MY\TRW5ITVJ?
DMS-79 NVjBUpNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:zbmlEPTB;NUCuO|Ehdk1? NHnmR3dUSU6JRWK=
RS4-11 NFHle4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T6bWlEPTB;NUCuPFghdk1? MYHTRW5ITVJ?
NCI-H720 NYL6T2pZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j0Z2lEPTB;NUGuNVEhdk1? NF7YcIhUSU6JRWK=
MC-CAR MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTOPGFFUUN3ME21NU42OiCwTR?= NWjGZ2ZkW0GQR1XS
TALL-1 MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ruN2lEPTB;NUOuPVEhdk1? MUHTRW5ITVJ?
NCI-N87 M{HwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfmSVVyUUN3ME21OE4yQCCwTR?= M1rKPHNCVkeHUh?=
P30-OHK MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTV2Lk[xJI5O M4HTU3NCVkeHUh?=
LP-1 MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV73[lNPUUN3ME22NU4zQCCwTR?= NWHFWXBZW0GQR1XS
YT MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[zWGlEPTB;NkGuPEBvVQ>? M4fXb3NCVkeHUh?=
MRK-nu-1 MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETvO|dKSzVyPU[xMlgzKG6P MnrvV2FPT0WU
BT-474 NUTQRnpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ryRWlEPTB;NkWgcm0> M2rkcHNCVkeHUh?=
NCI-H322M NWfxRXBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTZ4LkGxJI5O NWnv[JZYW0GQR1XS
NCI-H128 NXTqVpFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln0TWM2OD15ND63O{BvVQ>? MVXTRW5ITVJ?
KMS-12-PE NELtVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP5UYdKSzVyPUe2MlI1KG6P M1flRnNCVkeHUh?=
KP-N-YS Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXhTWM2OD15Nj63OEBvVQ>? MoHEV2FPT0WU
ALL-PO NX7VWo9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrqTWM2OD15Nz62OkBvVQ>? MorHV2FPT0WU
EW-13 M2nCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnRbplKSzVyPUe3Mlc3KG6P NEHX[nZUSU6JRWK=
EW-11 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvnTWM2OD15OD61NkBvVQ>? MX7TRW5ITVJ?
SK-N-FI MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm5WVBKSzVyPUiwMlIhdk1? NVLN[GlDW0GQR1XS
CAL-148 MoTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT5SJdpUUN3ME24NU45PCCwTR?= M1fDbHNCVkeHUh?=
RL MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTh4LkC5JI5O M1HvR3NCVkeHUh?=
AM-38 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFm2PZNKSzVyPUi4MlA5KG6P M3;LU3NCVkeHUh?=
RH-1 NIrCO2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf1WlJRUUN3ME25PU45PSCwTR?= NIqy[JhUSU6JRWK=
NCI-H1770 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLmTWM2OD1zMEKuOFkhdk1? M1fjNnNCVkeHUh?=
SIG-M5 M3zJfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHmSYVKSzVyPUGwOU4xPiCwTR?= NXzVSFJNW0GQR1XS
GR-ST M1\lUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j0TWlEPTB;MUGzMlM1KG6P NWTRZ4d2W0GQR1XS
ST486 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFzND6wOkBvVQ>? NIT4PGNUSU6JRWK=
NCI-H1650 MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjDN5ZRUUN3ME2xNVUvOjlibl2= M2PkXnNCVkeHUh?=
MHH-CALL-2 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\IXFF4UUN3ME2xNVUvPyCwTR?= M4\rb3NCVkeHUh?=
BV-173 M{H4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPETWM2OD1zMkKuO|Ehdk1? NVTwXVQ5W0GQR1XS
MC116 NHT2SIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF2OD64OUBvVQ>? M1rFRnNCVkeHUh?=
NCI-H524 NYPJbWF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTF3OT6xJI5O NIHVeG5USU6JRWK=
SCLC-21H NGHud4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[zNYFEUUN3ME2xOVkvPDFibl2= MmTpV2FPT0WU
NCI-H1304 M3rTc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnjTWM2OD1zNkmuNlEhdk1? MV\TRW5ITVJ?
NCI-H510A MmHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\NTWM2OD1zOEWuN|chdk1? NG\SO2RUSU6JRWK=
NCI-H209 MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\2SmR1UUN3ME2xPVYvPTJibl2= M{LvbnNCVkeHUh?=
KM-H2 NXLYeXpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3frV2lEPTB;MUm3MlA2KG6P NH:4dHVUSU6JRWK=
NCI-H1395 MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDEfnZHUUN3ME2yNVAvOTNibl2= M4TLRnNCVkeHUh?=
NCI-H1155 NHO1[5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jjRWlEPTB;MkOwMlMzKG6P NXrV[FZpW0GQR1XS
COR-L279 MkHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;R[ItKSzVyPUK1Nk4yPyCwTR?= M2TGdnNCVkeHUh?=
NCI-H1299 NHrDT2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K1c2lEPTB;Mk[xMlcyKG6P M4PC[XNCVkeHUh?=
EW-22 NFX3fI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu2dHRKSzVyPUK2N{44PSCwTR?= M3rsSHNCVkeHUh?=
SK-MEL-2 NYX6PVlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLZTWM2OD1{OEGuPUBvVQ>? NV7Id|VCW0GQR1XS
KASUMI-1 MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ6Mz6wOUBvVQ>? NYXadHd[W0GQR1XS
NCI-H187 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3QTWM2OD1{OEeuNFghdk1? Mlu3V2FPT0WU
NCI-H2171 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HkW2lEPTB;Mki4MlkzKG6P NXnZSXhPW0GQR1XS
LNCaP-Clone-FGC M2n4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljZTWM2OD1{OUWuNlYhdk1? MWXTRW5ITVJ?
NCI-H1522 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDDVGVKSzVyPUOwO{4xPSCwTR?= MWrTRW5ITVJ?
SCH NGfYZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTN{Mj6yNkBvVQ>? M3ri[3NCVkeHUh?=
THP-1 MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELSWm9KSzVyPUOyNk43KG6P MX\TRW5ITVJ?
SNU-C1 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TvVGlEPTB;M{[yMlA6KG6P NYT6enBXW0GQR1XS
CA46 NVPWXHJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDTOHJxUUN3ME2zO|MvPjNibl2= NWO5SnZGW0GQR1XS
NCI-H1963 M2fUS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTN6Nj6xPUBvVQ>? Mo\FV2FPT0WU
DEL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTN7MT6yO{BvVQ>? MYLTRW5ITVJ?
TUR MofJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nkTmlEPTB;M{m2MlYyKG6P Ml\vV2FPT0WU
NCI-H226 MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjOTIdIUUN3ME20NFMvOjNibl2= NYnUd4gzW0GQR1XS
COLO-668 MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTRyMz61O{BvVQ>? MXfTRW5ITVJ?
CPC-N NV3JVZp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NESydXBKSzVyPUSwN{44PyCwTR?= MXvTRW5ITVJ?
NCI-H889 NHW1fG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW5TWM2OD12NkGuPVIhdk1? MUjTRW5ITVJ?
J-RT3-T3-5 M3HVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Xa[GlEPTB;NUOyMlU4KG6P MVHTRW5ITVJ?
MSTO-211H M1e2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLoOmpKSzVyPUW3OE4zPiCwTR?= NI\KfG1USU6JRWK=
SCC-15 M2PydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTZ4Nz60O{BvVQ>? MVPTRW5ITVJ?
SUP-T1 NGfxXVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTZ6Nj6wOEBvVQ>? NHzO[ZpUSU6JRWK=
DMS-153 MlXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTd2Nj64N{BvVQ>? Ml[2V2FPT0WU
MS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrRTWM2OD15NUmuOFIhdk1? NIjKcXNUSU6JRWK=
TC-YIK M3XvSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\aTWM2OD15OEGuNFEhdk1? NGT2N4pUSU6JRWK=
RPMI-8866 M3;XSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L1ZWlEPTB;MUCwOk4zQCEQvF2= MnK5V2FPT0WU
KY821 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFyM{[uNFQh|ryP NWf3fWd3W0GQR1XS
P31-FUJ M4C1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D1ZmlEPTB;MUGxNk44PSEQvF2= M1rnNnNCVkeHUh?=
COLO-824 NVuz[lJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi1N2tKSzVyPUGyOlEvPzhizszN NUXlfoFoW0GQR1XS
U-698-M NY\Ed4ZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4m1bmlEPTB;MkK2Nk4yPSEQvF2= NVPvd5ZxW0GQR1XS
TE-441-T NXnkfmluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnldZYyUUN3ME2yOVIyNjdizszN M2PT[XNCVkeHUh?=
IMR-5 NIjtUWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnZeJhyUUN3ME2zOFA6NjZ{IN88US=> NGXsT4dUSU6JRWK=
NCI-H1838 M1vDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDjSm5KSzVyPUSxPFYvOzJizszN NWPVVIg1W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 The anticancer effects of bortezomib as a single agent have been demonstrated in xenograft models of multiple myeloma, adult T-cell leukemia, lung, breast, prostate, pancreatic, head and neck, and colon cancer, and in melanoma. [2] Oral bortezomib 1.0 mg/ kg daily for 18 days causes tumor growth delays, as well as a decrease in the number of metastases in the Lewis lung cancer model. Bortezomib at a single dose of up to 5 mg/kg significantly decreased the surviving fraction of breast tumor cells. Bortezomib 1.0 mg/kg administrated weekly for 4 weeks reduces tumor growth by 60% in murine xenograft models of prostate cancer. 1.0 mg/kg Bortezomib administration for 4 weeks results in a 72% or 84% reduction in pancreatic cancer murine xenografts growth, as well as an increase in tumor cell apoptosis. 1.0 mg/kg Bortezomib treatment results in significant inhibition of human plasmacytoma xenograft growth, increase in tumor cells apoptosis and overall survival, and a decrease in tumor angiogenesis. [3]
臨床試験 A phase I study of weekly subcutaneous Bortezomib in patients with steroid-refractory or -dependent chronic graft versus host disease is currently in recruiting.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[4]

Kinetic Methods In a typical kinetic run, 2.00 mL of assay buffer (20 mM HEPES, 0.5 mM EDTA, 0.035% SDS, pH 7.8) and Suc-Leu-Leu-Val-Tyr-AMC in DMSO are added to a 3 mL fluorescence cuvette, and the cuvette is placed in the jacketed cell holder of a fluorescence spectrophotometer. Reaction temperature is maintained at 37℃ by a circulating water bath. After the reaction solution has reached thermal equilibrium (5 minutes), 1 μL−10 μL of the stock enzyme solution is added to the cuvette. Reaction progress is monitored by the increase in fluorescence emission at 440 nm (λex= 380 nm) that accompanies cleavage of AMC from peptide-AMC substrates.

細胞アッセイ:

[5]

細胞株 Human multiple myeloma cells line U266
濃度 ~10 μM
反応時間 2 days
実験の流れ

The inhibitory effect of Bortezomib on cell growth is assessed by measuring MTT dye absorbance of the cells. Cells from 48-hour cultures are pulsed with 10 μL of 5 mg/mL MTT to each well for the last 4 hour of 48-hour cultures, followed by 100 μL of isopropanol containing 0.04 N HCl. Absorbance is measured at 570 nm using a spectrophotometer.

動物実験:

[3]

動物モデル Human plasmacytoma xenografts RPMI 8226
製剤 Saline
投薬量 1 mg/kg
投与方法 i.v. twice weekly for 4 weeks, then once weekly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Bortezomib (PS-341) SDF
分子量 384.24
化学式

C19H25BN4O4

CAS No. 179324-69-7
保管 3年-20℃
2年-80℃in solvent
別名 LDP-341, MLM341
溶解度 (25°C) * In vitro DMSO 76 mg/mL (197.79 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 B-​[(1R)​-​3-​methyl-​1-​[[(2S)​-​1-​oxo-​3-​phenyl-​2-​[(2-​pyrazinylcarbonyl)​amino]​propyl]​amino]​butyl]​-boronic acid

文献中の引用 (142)

Frequently Asked Questions

  • Question 1
    On your website, it is mentioned that Bortezomib should be prepared at a concentration of 5 mg/ml in 2% DMSO/30% PEG300/ddH2O for in vivo use. But on the product sheet we received with the compound, it is mentioned: 5mg/ml in 0.5% methylcellulose, 0.2% tween 80. So which is the correct preparation buffer?

    Answer: S1013 Bortezomib in 2% DMSO+30% PEG 300+ddH2O at 5 mg/ml is a clear solution, and it in 0.5% methylcellulose+0.2% Tween 80 is a suspension. Please choose the suitable vehicle according to your administration route. When you prepare the clear solution, please dissolve Bortezomib in DMSO first, make sure it dissolves well, warm it up to 45 degree and/or sonicate if necessary, then add PEG, mix well, and finally add water.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related プロテアソーム 阻害剤

  • VR23

    VR23は1種の有効なプロテアソーム阻害剤で、トリプシン様プロテアソーム(trypsin-like proteasomes)、キモトリプシン様プロテアソーム(chymotrypsin-like proteasomes)とカスパーゼ様プロテアソーム(caspase-like proteasomes)に作用するIC50値は1 nM、50-100 nMと 3 μMそれぞれに分かれます。

  • Calpeptin

    Calpeptinは1種の有効的で、細胞浸透性のカルパイン( calpain)阻害剤で、カルパインI(豚赤血球)、カルパインII (豚腎臓)、パパイン(Papain)とカルパインI(人血小板)に対するID50値は52 nM、34 nM、138 nMと40 nMそれぞれに分かれます。

  • Marimastat (BB-2516)

    Marimastat (BB-2516)は1種の広範囲に使用されるマトリックスメタロプロテアーゼ(MMP)阻害剤で、MMP-9、MMP-1、MMP-2、MMP-14とMMP-7に作用する IC50値は3 nM、5 nM、6 nM、9 nMと13 nMそれぞれに分かれます。臨床3期。

  • Ledipasvir (GS5885)

    Ledipasvir(GS5885)は1種のHCV NS5Aポリメラーゼ(polymerase)阻害剤で、C型肝炎ウイルス感染の治療に使用します。

  • MG-132

    MG-132は、100nMのIC50によるプロテアソームの強力な阻害剤です。

  • Carfilzomib (PR-171)

    Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM.

  • Ixazomib (MLN2238)

    Ixazomib (MLN2238)は窒素端加帽の二ペプチドロイシンホウ酸で、20Sプロテアソームのカイモトリプシン類(β5)加水分解部位を抑制、IC50が3.4nM、Ki値が0.93nM。

    Features:A first-in-class proteasome inhibitor that has improved pharmacokinetics (PK), pharmacodynamics(PD), and antitumor activity in preclinical studies.

  • ONX-0914 (PR-957)

    ONX-0914(PR-957)は、恒常的プロテアソームのための最小限の交差反応性を持つ強力かつ選択的な免疫プロテアソームの阻害剤です。

    Features:The first highly selective, small molecule inhibitor of the immunoproteasome. Potential use in cancer and autoimmune diseases (e.g. rheumatoid arthritis, inflammatory bowel disease, and lupus).

  • MLN9708

    MLN9708は二代目経口生物の有効性にプロテアソーム選択阻害剤で、20Sプロテアソームのカイモトリプシン類(β5)加水分解部位に作用すると、IC50が3.4nM、Ki値が0.93nMになる。

    Features:The 1st oral proteasome inhibitor in early stage clinical trials for Multiple Myeloma.

最近チェックしたアイテム

Tags: Bortezomib (PS-341)を買う | Bortezomib (PS-341)供給者 | Bortezomib (PS-341)を購入する | Bortezomib (PS-341)費用 | Bortezomib (PS-341)生産者 | オーダーBortezomib (PS-341) | Bortezomib (PS-341)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ