Afatinib (BIBW2992)

Afatinib (BIBW2992)はEGFR/HER2( EGFR(wt)、EGFR(L858R)、EGFR(L858R/T790M) とHER2を含める)を不可逆に抑制して、無細胞試験でIC50値が0.5 nM,0.4 nM,10 nM 和 14 nMにそれえぞれ分かれることです。

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Afatinib (BIBW2992) 化学構造
分子量: 485.94

高品質保証

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カスタマーフィードバック(3)

MSDS

製品説明

  • Compare EGFR Inhibitors
    EGFR製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法
  • Afatinib (BIBW2992)のメカニズム

製品の説明

生物活性

製品説明 Afatinib (BIBW2992)はEGFR/HER2( EGFR(wt)、EGFR(L858R)、EGFR(L858R/T790M) とHER2を含める)を不可逆に抑制して、無細胞試験でIC50値が0.5 nM,0.4 nM,10 nM 和 14 nMにそれえぞれ分かれることです。
ターゲット

EGFRwt

EGFRL858R

EGFR L858R/T790M

HER2

IC50

0.5 nM

0.4 nM

10 nM

14 nM [1]

In vitro試験 BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
HDLM-2 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEC1O|Ih|ryP M3:1ZnNCVkeHUh?=
KASUMI-1 NVnUV2NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEC5NVEh|ryP MoHUV2FPT0WU
HCC2218 NV7pdWwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3XfXJKSzVyPUCuNFA6QDdizszN MnXPV2FPT0WU
KARPAS-45 NHHPbpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEG2O|Eh|ryP M3XFcXNCVkeHUh?=
HSC-4 NX70V2NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEG3OFgh|ryP NEnPeFVUSU6JRWK=
CHL-1 M3vNSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEG4N|kh|ryP MYTTRW5ITVJ?
KY821 M1WwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjpT|VRUUN3ME2wMlAzODZizszN M3\qb3NCVkeHUh?=
NCI-N87 Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK2cYxKSzVyPUCuNFI4PzNizszN NYj3eIVjW0GQR1XS
DOK M1S5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzTTWM2OD1yLkCzNVk1KM7:TR?= NGiySppUSU6JRWK=
DSH1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDm[2tKSzVyPUCuNFM{OTRizszN MmfjV2FPT0WU
MDA-MB-175-VII MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMEO0NVYh|ryP M4n0fnNCVkeHUh?=
NCI-H2170 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL3TWM2OD1yLkCzO|I5KM7:TR?= M3;QfXNCVkeHUh?=
BT-474 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHrNGZsUUN3ME2wMlA1QTh4IN88US=> MmGxV2FPT0WU
EFO-27 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrEPJpVUUN3ME2wMlA2OTh{IN88US=> M13tN3NCVkeHUh?=
NCI-H720 M3nsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEWzNlUh|ryP MYnTRW5ITVJ?
PC-14 MmfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEW2Olgh|ryP MVfTRW5ITVJ?
EC-GI-10 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O0OGlEPTB;MD6wOVkyOiEQvF2= MYDTRW5ITVJ?
KYSE-450 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vkN2lEPTB;MD6wOVk4QCEQvF2= MXrTRW5ITVJ?
BPH-1 NUnEb29PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPFWmxKSzVyPUCuNFU6QDhizszN M3;xR3NCVkeHUh?=
NCI-H292 M4foeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3ReJdqUUN3ME2wMlA3ODlizszN MmXnV2FPT0WU
H9 M{Syc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEexN|Ih|ryP MoryV2FPT0WU
NCI-H526 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILzRlRKSzVyPUCuNFc5OjNizszN MUfTRW5ITVJ?
NCI-H1623 NHf1VJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPQ[2hKSzVyPUCuNFgxOjVizszN NYHxPGc5W0GQR1XS
KYSE-140 NHjhUHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjBcnNKSzVyPUCuNFg{OyEQvF2= MmnhV2FPT0WU
Ca9-22 NHvzeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWOwUpJ4UUN3ME2wMlA5OzV|IN88US=> M4jVbnNCVkeHUh?=
AU565 MknIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEi1NFQh|ryP M2nFXXNCVkeHUh?=
ZR-75-30 M1jFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TMOmlEPTB;MD6wPVU1PSEQvF2= MlzHV2FPT0WU
NCI-H1770 MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXT5V4xDUUN3ME2wMlExOjhizszN NYHmXVFqW0GQR1XS
LB2241-RCC NH3z[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf4ZWVTUUN3ME2wMlExQDh2IN88US=> NHy1WmhUSU6JRWK=
CAL-39 M4LPWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMUG3PVIh|ryP MYnTRW5ITVJ?
UACC-893 NWfTO4I2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\lV2N2UUN3ME2wMlEyQDh3IN88US=> MnXOV2FPT0WU
LU-65 M3vrN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TON2lEPTB;MD6xNlY{OyEQvF2= MVTTRW5ITVJ?
HN NYqzTZoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzSTWM2OD1yLkGzNFc4KM7:TR?= MmLiV2FPT0WU
TI-73 NIL3UJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS4TWM2OD1yLkG0O|E2KM7:TR?= MVzTRW5ITVJ?
KU812 M4Xke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LIWmlEPTB;MD6xOVQ2PiEQvF2= MWTTRW5ITVJ?
SW13 M4fJTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPJWnlMUUN3ME2wMlE3OjF4IN88US=> M2DLNXNCVkeHUh?=
BB30-HNC M4PUW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M161dWlEPTB;MD6xOlU4PiEQvF2= NUnO[JdJW0GQR1XS
HSC-2 Ml3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPHNoVKSzVyPUCuNVY5OzdizszN MnPCV2FPT0WU
BV-173 Mo\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPETWM2OD1yLkG3OVk3KM7:TR?= Ml[xV2FPT0WU
CAL-27 NFPUUY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMUe2N|Yh|ryP NYm4eYxSW0GQR1XS
SBC-1 NHHEPGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMUi5OVkh|ryP MUfTRW5ITVJ?
CAL-33 NFrKVGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37QVmlEPTB;MD6yNFE5PCEQvF2= M1H4UXNCVkeHUh?=
NCI-H209 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDvU5YxUUN3ME2wMlIxPDZizszN M3\Ud3NCVkeHUh?=
COR-L105 NYjWUHRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTUTWM2OD1yLkKxNFg1KM7:TR?= Mk[1V2FPT0WU
HSC-3 NEH5eo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LMXmlEPTB;MD6yNVE6QCEQvF2= MlXQV2FPT0WU
NCI-H69 M4DQOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3tTWM2OD1yLkKxOFUyKM7:TR?= NVfyOo17W0GQR1XS
MOLT-13 MoDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHVNm1kUUN3ME2wMlI{QTd3IN88US=> MUjTRW5ITVJ?
ML-2 NHH4XnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVOxd2hOUUN3ME2wMlI1QDB{IN88US=> NHPQTGZUSU6JRWK=
IGROV-1 M4CxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nkNWlEPTB;MD6yOVk2OiEQvF2= MUHTRW5ITVJ?
TK10 NUfOd45FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjh[2tKSzVyPUCuNlY4OzhizszN NGPiPHRUSU6JRWK=
EoL-1-cell NGLKOmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nYTWlEPTB;MD6yOlg6OiEQvF2= NXfYSWltW0GQR1XS
HO-1-N-1 M1rNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDnTWM2OD1yLkK3PFU{KM7:TR?= MnLUV2FPT0WU
BHY NYHrOmRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMki2OVUh|ryP NX3kT5RxW0GQR1XS
LU-139 NH3P[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwM{C1NUDPxE1? NIfRVnhUSU6JRWK=
23132-87 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwM{G5NlMh|ryP MnW2V2FPT0WU
ACHN M2XFbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\2d3dKSzVyPUCuN|E6QTRizszN MX\TRW5ITVJ?
DoTc2-4510 NXfYOpRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfYTWM2OD1yLkOyNlE6KM7:TR?= MnnMV2FPT0WU
BB65-RCC NILocndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33i[GlEPTB;MD6zOFU6OyEQvF2= MX3TRW5ITVJ?
HLE MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTyOmVyUUN3ME2wMlM2ODR4IN88US=> NVnvW5lGW0GQR1XS
HCC1419 M4jCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3VTWM2OD1yLkO2OFA5KM7:TR?= MUfTRW5ITVJ?
A388 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL6TWM2OD1yLkO2PFU4KM7:TR?= MVjTRW5ITVJ?
NUGC-3 NIPHUZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTmSIJqUUN3ME2wMlM5Ozd|IN88US=> NYOzeopHW0GQR1XS
KYSE-180 Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HYe2lEPTB;MD6zPVA5QSEQvF2= NIG2empUSU6JRWK=
TE-6 M3vROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjnTWM2OD1yLkSwNlQ3KM7:TR?= M{OyfXNCVkeHUh?=
A498 M3HhRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwNEC2O|Qh|ryP MYDTRW5ITVJ?
NCI-H1648 M3u0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW1ZoJKSzVyPUCuOFQyQDJizszN NWrqfmtZW0GQR1XS
DU-145 M3XjWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrjTWM2OD1yLkS0PFM{KM7:TR?= MVvTRW5ITVJ?
CW-2 Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnrU|BbUUN3ME2wMlQ3QTF2IN88US=> M1KwZXNCVkeHUh?=
A431 MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7xTWM2OD1yLkS4NlM{KM7:TR?= MkC3V2FPT0WU
SAS NE\wRXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrBTWM2OD1yLkS4N|k5KM7:TR?= M2ntXXNCVkeHUh?=
NCI-H2126 MlnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwNUG5NlYh|ryP NHq0O3ZUSU6JRWK=
NCI-H358 M4jrU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWriXZdwUUN3ME2wMlU{OjFizszN MlT1V2FPT0WU
FADU MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwNUS0NFQh|ryP MoLRV2FPT0WU
ACN NUXtVppJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2P6fWlEPTB;MD61OVA6PCEQvF2= MmXZV2FPT0WU
HCC70 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwNUe2OlEh|ryP MVrTRW5ITVJ?
NCI-H1838 Ml7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf4dVVKSzVyPUCuOlAzQTlizszN NEnhR2lUSU6JRWK=
CAL-54 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPIc2JOUUN3ME2wMlYyPjJzIN88US=> NX:4TYdXW0GQR1XS
NCI-H1975 NIHkNVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTTTXlCUUN3ME2wMlYyPzJ6IN88US=> M3TMZ3NCVkeHUh?=
COR-L88 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7nZ2Q1UUN3ME2wMlY1OTF|IN88US=> M1Hnb3NCVkeHUh?=
CTV-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3jTWM2OD1yLk[0N|kzKM7:TR?= NHLoTXZUSU6JRWK=
EW-18 Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwNki2PVgh|ryP MoLsV2FPT0WU
HCC1806 NV3n[4VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HtW2lEPTB;MD62PVY3PiEQvF2= NHL1PWJUSU6JRWK=
HuP-T4 M3W0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PWWWlEPTB;MD62PVc3KM7:TR?= NVXpWmE5W0GQR1XS
MDA-MB-361 NYXnNYl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjoTWM2OD1yLkeyOlYzKM7:TR?= MnjBV2FPT0WU
NCI-H1573 MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITkRYlKSzVyPUCuO|M3OyEQvF2= M4\GR3NCVkeHUh?=
KU-19-19 NIK4VYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwN{e0OlQh|ryP MVLTRW5ITVJ?
COLO-678 NWXy[Zl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL5NVBQUUN3ME2wMlgxQDN2IN88US=> NG\JZ|ZUSU6JRWK=
C-33-A MkHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\UU5ZvUUN3ME2wMlgyOjl5IN88US=> MlzrV2FPT0WU
Calu-3 NVe2ZpJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjqRVlGUUN3ME2wMlgyPDN2IN88US=> MkPFV2FPT0WU
AGS M3PoUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwOEO2OFgh|ryP NIXJZXpUSU6JRWK=
SCC-25 NE\SRXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\kUZY6UUN3ME2wMlg1OTdzIN88US=> MmrOV2FPT0WU
JVM-2 NV\CXJdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwOEiyPVkh|ryP NGGz[VhUSU6JRWK=
HCE-T MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwOEi0Nlgh|ryP MUHTRW5ITVJ?
ES4 NFT4cVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDETWM2OD1yLkm3PFM3KM7:TR?= MYXTRW5ITVJ?
EKVX M3LKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7C[IRKSzVyPUGuNFExPjRizszN M{LGeXNCVkeHUh?=
D-542MG MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TWZ2lEPTB;MT6wNVA3PCEQvF2= Mn;KV2FPT0WU
SW1116 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnoTWM2OD1zLkCxNlg4KM7:TR?= M4HXRXNCVkeHUh?=
5637 NVThTFJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zzWWlEPTB;MT6wNVUyKM7:TR?= MmnHV2FPT0WU
HT-1376 NFj6XItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr6V|FJUUN3ME2xMlAyPTF|IN88US=> M1y1[3NCVkeHUh?=
NB69 NGfPRpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHlVXhKSzVyPUGuNFI6PDVizszN NYjRXY9wW0GQR1XS
YKG-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\qTWM2OD1zLkC1OFE6KM7:TR?= M3v3NXNCVkeHUh?=
EW-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFwMEe4PFMh|ryP MlzNV2FPT0WU
GCIY NXG0PZU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXyc2tNUUN3ME2xMlA5OTB2IN88US=> NWTG[HZLW0GQR1XS
SK-MES-1 NFryS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDDRotKSzVyPUGuNVE1QDdizszN MWfTRW5ITVJ?
PANC-08-13 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjOTIszUUN3ME2xMlE3PDF4IN88US=> MkfXV2FPT0WU
SK-NEP-1 NFrUVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy3eVVlUUN3ME2xMlE4PTF|IN88US=> NVTWXYg{W0GQR1XS
SW954 NHPmT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPQdYJtUUN3ME2xMlIxOjF2IN88US=> MV;TRW5ITVJ?
NCI-SNU-5 NWHkTJhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjwVJVKSzVyPUGuNlM6KM7:TR?= M{X0[HNCVkeHUh?=
SW48 MnPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO3TWM2OD1zLkK1OFMzKM7:TR?= MWfTRW5ITVJ?
HT-3 MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHDTWM2OD1zLkK4O|U{KM7:TR?= M4ryVXNCVkeHUh?=
ETK-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFwM{e0OVYh|ryP Moe2V2FPT0WU
SCC-15 NV3KSHJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TZOWlEPTB;MT6zPVQ2OSEQvF2= NX;pWmtYW0GQR1XS
DU-4475 NFK5[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTFwNECxNlEh|ryP MoTZV2FPT0WU
NB5 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mni3TWM2OD1zLkSxN|E4KM7:TR?= M4jZO3NCVkeHUh?=
CFPAC-1 NGXQV3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFwNEK0PVMh|ryP NHfM[VVUSU6JRWK=
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BE-13 NVPYR4JkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfxU|d3UUN3ME23Mlk5OTF{IN88US=> MoDuV2FPT0WU
VMRC-RCZ M1vve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfufW5FUUN3ME24MlAyPjl5IN88US=> NVfEXm1lW0GQR1XS
NCI-H727 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRThwMUC0NkDPxE1? MWTTRW5ITVJ?
SW1710 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rGRmlEPTB;OD6xPFUyPSEQvF2= MnHEV2FPT0WU
D-502MG NWfZT2xnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\R[2FNUUN3ME24MlI6Ojh{IN88US=> NH25XJhUSU6JRWK=
NCI-H1993 M1Hvfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDYZmtKSzVyPUiuN|M3OzFizszN MoXyV2FPT0WU
SCC-4 M{\kRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTJTWM2OD16LkS0NFU6KM7:TR?= NIDyPIZUSU6JRWK=
HAL-01 MlPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\iUItKSzVyPUiuOVE6OSEQvF2= M{HMbnNCVkeHUh?=
GT3TKB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrmTWM2OD16Lk[3PVY1KM7:TR?= MoDOV2FPT0WU
SK-OV-3 MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPDTWM2OD16LkexN|I6KM7:TR?= NGnab3dUSU6JRWK=
COLO-829 NYrBPHdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzOTXkyUUN3ME24MlgxQTd4IN88US=> NIDTUoZUSU6JRWK=
OCI-AML2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fWNmlEPTB;OD65OVQ5OSEQvF2= NIn1OJJUSU6JRWK=
OS-RC-2 M2TjWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfPNYZKSzVyPUmuNFIyQSEQvF2= M3P0fnNCVkeHUh?=
BFTC-909 MmrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXDeWNQUUN3ME25MlA3Pzl7IN88US=> NXfVSlhiW0GQR1XS
EW-11 M3\IbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vOXmlEPTB;OT6xO|Y2OyEQvF2= MUfTRW5ITVJ?
HCE-4 NXLZRVhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTlwMkG1OVgh|ryP NXfXfFRkW0GQR1XS
BALL-1 NVq5fo1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPmbmdKSzVyPUmuNlE6ODdizszN NX;UVpBlW0GQR1XS
SF539 M1vUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTHTWM2OD17LkKzOVYzKM7:TR?= Ml25V2FPT0WU
CAMA-1 MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFqwUW1KSzVyPUmuNlgyOjhizszN NI\SRW1USU6JRWK=
C32 NXz5NGp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;pTWM2OD17LkOzNFY1KM7:TR?= NXLZdVFZW0GQR1XS
NCI-H1703 NX22U3oyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnEXVFGUUN3ME25MlM1Ozd3IN88US=> MnPtV2FPT0WU
NCI-H1650 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHKPY9TUUN3ME25MlYxQTR4IN88US=> MXrTRW5ITVJ?
NCI-H1563 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17TT2lEPTB;OT63OlA{OSEQvF2= NI\ZUGJUSU6JRWK=
CAL-85-1 M2\i[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e1fmlEPTB;OT64O|M5OyEQvF2= M3L5fnNCVkeHUh?=
UM-UC-3 M1vvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfDTWM2OD17Lkm1NFMh|ryP MnWzV2FPT0WU
BxPC-3 NHW2SXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXjTWM2OD1zMD6wPVczKM7:TR?= M1\UTHNCVkeHUh?=
MHH-PREB-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkK1TWM2OD1zMD6xPVk6KM7:TR?= M{W5PHNCVkeHUh?=
DEL M1joS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPaZZJKSzVyPUGwMlM6PDZizszN MmrlV2FPT0WU
HuCCT1 NYTEUlFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPsdmtGUUN3ME2xNE43ODN|IN88US=> NGPCWG1USU6JRWK=
OVCAR-4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnDTWM2OD1zMD64PFM2KM7:TR?= NGjFVWdUSU6JRWK=
CAL-72 M4\hemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoD6TWM2OD1zMD65N|kyKM7:TR?= MlXFV2FPT0WU
HCC1954 NUTPRpdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUL0T4dyUUN3ME2xNU4xPzV2IN88US=> Mm\DV2FPT0WU
EFO-21 M1fp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLSTWM2OD1zMT6xNFQ2KM7:TR?= MXjTRW5ITVJ?
FTC-133 NV7NRmR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli0TWM2OD1zMT6xOFA4KM7:TR?= MYTTRW5ITVJ?
SK-MEL-24 M3LCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTFzLkKzOlYh|ryP MXfTRW5ITVJ?
UACC-62 NYnzeVRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\BboZKSzVyPUGxMlI{PjhizszN M3iyTnNCVkeHUh?=
NCI-H650 M33vcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TnUWlEPTB;MUGuNlQyQCEQvF2= MWXTRW5ITVJ?
ALL-PO MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rlXmlEPTB;MUGuNlUyOiEQvF2= MXnTRW5ITVJ?
T84 MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrweVZKSzVyPUGxMlM6ODdizszN MYTTRW5ITVJ?
IST-MEL1 NYC3cYhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zqS2lEPTB;MUGuOFU2QSEQvF2= MonzV2FPT0WU
SW626 M4\sfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLzeodKSzVyPUGxMlU4PTVizszN MkLPV2FPT0WU
RPMI-2650 NUXiUnVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTFzLkW4PFUh|ryP M1ToR3NCVkeHUh?=
MC-IXC Ml7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;Hd2lEPTB;MUGuOlczQCEQvF2= MlfrV2FPT0WU
HOP-62 MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIizfllKSzVyPUGxMlY4PjRizszN MXTTRW5ITVJ?
NOS-1 M{ftfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHkOFFKSzVyPUGxMlcyODlizszN MnfPV2FPT0WU
SW1573 MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jpPWlEPTB;MUGuO|I6PSEQvF2= MWfTRW5ITVJ?
WM-115 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTFzLke1PFgh|ryP NGjBPGhUSU6JRWK=
HuO9 NIL4[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTITWM2OD1zMT64O|c1KM7:TR?= MlzMV2FPT0WU
YAPC NHXqRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEG1RoVKSzVyPUGxMlkzPTlizszN MXXTRW5ITVJ?
MDA-MB-453 M1Oxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFzLkm1NVUh|ryP Mo\BV2FPT0WU
NCI-H596 NXPBZ5V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTF{LkCzOlkh|ryP NXPrV4pEW0GQR1XS
A172 M4ftUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\IPGlEPTB;MUKuNFc6QCEQvF2= NWjQ[Y41W0GQR1XS
RS4-11 NYmye4ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rsZmlEPTB;MUKuNVczPSEQvF2= MnLtV2FPT0WU
HCC1937 M2nQPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTF{Lke1OlQh|ryP MVvTRW5ITVJ?
SW837 NHfBenhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvGT4JHUUN3ME2xNk46ODJ6IN88US=> M3fJRXNCVkeHUh?=
NMC-G1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLwPIhbUUN3ME2xNk46OjN2IN88US=> M2jIOnNCVkeHUh?=
PFSK-1 NUCwWmk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XlTWlEPTB;MUOuNFYh|ryP NF;WSXVUSU6JRWK=
DBTRG-05MG NHjocZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTF|LkC2N|Ih|ryP NVy5UmZDW0GQR1XS
SK-UT-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF|LkGwPFMh|ryP NYTIdI9xW0GQR1XS
OVCAR-5 MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4W2UmlEPTB;MUOuNVU6OyEQvF2= M4HnOXNCVkeHUh?=
8505C NEHnRo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF|LkKwOlch|ryP NHjmVlFUSU6JRWK=
SK-MEL-1 NFvL[ItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rtOmlEPTB;MUOuO|E{PSEQvF2= MmXGV2FPT0WU
LK-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDWTWM2OD1zMz63OlM6KM7:TR?= NHvzTpRUSU6JRWK=
OE33 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzlcWpKSzVyPUGzMlc5PiEQvF2= M2foVHNCVkeHUh?=
Ramos-2G6-4C10 Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT5eZh{UUN3ME2xOE4xOjB{IN88US=> NXPJflVsW0GQR1XS
EW-13 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\5TWM2OD1zND6wN|UzKM7:TR?= M4XFSHNCVkeHUh?=
NCI-H1793 MonjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLxVXVGUUN3ME2xOE4zODh5IN88US=> NYO1W|RHW0GQR1XS
BHT-101 NG\wTnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXVSZlKSzVyPUG0MlI1OSEQvF2= NHPyTIRUSU6JRWK=
RKO NETG[5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDYTWM2OD1zND61NFc2KM7:TR?= MXzTRW5ITVJ?
NEC8 M4HJN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHaeFlHUUN3ME2xOE42PDd{IN88US=> MnT0V2FPT0WU
PANC-10-05 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF2Lk[yOFch|ryP NVHuVmg6W0GQR1XS
NCI-H2030 MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfYfHhQUUN3ME2xOE43PDR6IN88US=> NFS2bW5USU6JRWK=
C2BBe1 M1PObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF2Lke2OEDPxE1? NWXvbYJrW0GQR1XS
EM-2 NXH2XlY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTFTWM2OD1zND64OVc3KM7:TR?= MkLRV2FPT0WU
HCC1395 NHS0fplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\ITWM2OD1zND65N|M5KM7:TR?= MUHTRW5ITVJ?
A2058 NXSwdm9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnWN2VKSzVyPUG1MlA1ODlizszN NUfRbHFUW0GQR1XS
SW1463 M{PFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTUWowyUUN3ME2xOU4xPDh3IN88US=> Ml3kV2FPT0WU
J82 NIflc4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF3LkC1O{DPxE1? MWTTRW5ITVJ?
CAL-120 M4XreWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF3LkG0OFch|ryP MV;TRW5ITVJ?
COLO-824 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTF3LkG1O|kh|ryP MmW2V2FPT0WU
LNCaP-Clone-FGC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXQS4xRUUN3ME2xOU41OjR6IN88US=> NX72flQ4W0GQR1XS
CP66-MEL M1LzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTF3LkS2PFgh|ryP M1TJbHNCVkeHUh?=
OC-314 M{jCUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf3TWM2OD1zNT60O|E1KM7:TR?= MYjTRW5ITVJ?
OVCAR-8 MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF3Lki4OlEh|ryP NUjpSINGW0GQR1XS
MFE-280 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXrNJZKSzVyPUG2MlA1QDhizszN MkjxV2FPT0WU
MHH-NB-11 M4T2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX0TWM2OD1zNj6wPFM6KM7:TR?= Mm[xV2FPT0WU
SW1990 NX7KRVFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33GdmlEPTB;MU[uNVc2PSEQvF2= NEnJU4tUSU6JRWK=
U-266 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TXcWlEPTB;MU[uNlI6QSEQvF2= M4Tze3NCVkeHUh?=
MFM-223 NUjzUHFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTF4LkO5OlUh|ryP MUTTRW5ITVJ?
L-363 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PBNGlEPTB;MU[uOFU4PyEQvF2= NI\rN3FUSU6JRWK=
MCF7 NFXjWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXxTWM2OD1zNj60O|I{KM7:TR?= NXXy[lAzW0GQR1XS
SK-MEL-3 NIXpRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF4LkS3PFch|ryP M4\DUnNCVkeHUh?=
HH NGLGSFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXoUFFKSzVyPUG2MlUyPjJizszN M33nW3NCVkeHUh?=
no-10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M170fWlEPTB;MU[uOlM1OyEQvF2= NVHUbZhLW0GQR1XS
HuP-T3 M3LYUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH4U4xKSzVyPUG2MlY2PzZizszN M4m3fnNCVkeHUh?=
QIMR-WIL NYfxVIE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P1d2lEPTB;MU[uO|ExPSEQvF2= MV;TRW5ITVJ?
NCI-H1092 NV3x[WlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPpfVJKSzVyPUG2Mlg{OTZizszN MVLTRW5ITVJ?
MZ2-MEL NUPTcnpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP3blFuUUN3ME2xOk45PDB|IN88US=> MWLTRW5ITVJ?
ES3 NXOweJdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHjfolKSzVyPUG2MlkyOzRizszN NWSwNHk3W0GQR1XS
COLO-684 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\U[2VKSzVyPUG2Mlk1PzdizszN M4qwXnNCVkeHUh?=
NCI-H661 NWHKcYRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjOVFBFUUN3ME2xOk46Pjl2IN88US=> M1vVWHNCVkeHUh?=
CP50-MEL-B NELoN|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nu[WlEPTB;MUeuNFM1OyEQvF2= MkPmV2FPT0WU
NCI-H2405 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTF5LkG5O|Qh|ryP MYjTRW5ITVJ?
U-2-OS MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfmTWM2OD1zNz61N|A4KM7:TR?= M4HDXXNCVkeHUh?=
RERF-LC-MS NWLxRY97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlGxTWM2OD1zNz61OVA5KM7:TR?= NVTNbGFLW0GQR1XS
NCI-H2342 M2TtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;ETWM2OD1zNz61OVch|ryP M{XPNHNCVkeHUh?=
ES8 M1HrUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH4dlI{UUN3ME2xO{43ODh5IN88US=> Mme3V2FPT0WU
MOLT-16 MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3mfYlkUUN3ME2xO{45QTN2IN88US=> M3\2Z3NCVkeHUh?=
RH-18 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;GOGlEPTB;MUiuNFA{PSEQvF2= NVL2emxTW0GQR1XS
D-283MED MlrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLxToVkUUN3ME2xPE4xODh6IN88US=> NWLET41qW0GQR1XS
RCC10RGB MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTF6LkC1OVkh|ryP NUnrN4pnW0GQR1XS
NCI-H1437 Mn;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rQTmlEPTB;MUiuNVY1OSEQvF2= M1\POHNCVkeHUh?=
SW982 NWK2[5I2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrGU5B5UUN3ME2xPE4zPjdzIN88US=> Mkf3V2FPT0WU
IST-MES1 M1H0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLhTmx3UUN3ME2xPE41PDJ6IN88US=> NGH1RpVUSU6JRWK=
A704 NIfsT3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\nN2lEPTB;MUiuOFc2OyEQvF2= Ml3HV2FPT0WU
ESS-1 NFjxXnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jQd2lEPTB;MUiuOVIxPSEQvF2= NH\qUpRUSU6JRWK=
SCH MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nXOWlEPTB;MUiuOlQ2PiEQvF2= MnfVV2FPT0WU
COLO-320-HSR NHn0VmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLCTWM2OD1zOD63OFYh|ryP NH7qfplUSU6JRWK=
Mo-T NYDEPFk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknZTWM2OD1zOD64NlA1KM7:TR?= NEXQW3lUSU6JRWK=
Saos-2 M1rvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF7LkGxOlIh|ryP M2nySnNCVkeHUh?=
SW684 MlTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTF7LkGzNlYh|ryP MlnDV2FPT0WU
KMOE-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXTTWM2OD1zOT6yNlQzKM7:TR?= NXj4c4dTW0GQR1XS
MMAC-SF M1ntbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLVTWM2OD1zOT6yOlA4KM7:TR?= NFnLSY5USU6JRWK=
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HT NIfoeodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zFe2lEPTB;NECuOlY{QSEQvF2= NXj1XG9mW0GQR1XS
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A101D NHr0UGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXHTWM2OD12OT65OFI2KM7:TR?= NEPadHNUSU6JRWK=
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... Click to View More Cell Line Experimental Data

In vivo試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]
臨床試験 A Phase II clinical trial of BIBW2992 for the treatment of cancer has been terminated.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

In vitro kinase activity assays The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.

細胞アッセイ:

[1]

細胞株 NSCLC cells
濃度 0-10 μM
反応時間 1 hour
実験の流れ

1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.

動物実験:

[1]

動物モデル Athymic NMRI-nu/nu female mice
製剤 In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
投薬量 20 mg/kg
投与方法 Oral administration

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Afatinib (BIBW2992) SDF
分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 10mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

文献中の引用 (35)

Frequently Asked Questions

  • Question 1
    What’s the recommendation about reconstitution of the compound for in vivo animal study?

    Answer: For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

技術サポート&よくある質問(FAQ)

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Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)代理店
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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