Afatinib (BIBW2992) 化学構造
分子量: 485.94

高品質保証

文献中の引用(34)

カスタマーフィードバック(3)

Quality Control & MSDS

製品説明

  • Compare EGFR Inhibitors
    EGFR製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法
  • Afatinib (BIBW2992)のメカニズム

製品の説明

生物活性

製品説明 Afatinib (BIBW2992)は不可逆的にEGF受容体/ HER2含むEGF受容体を抑制、 EGFR L858R , EGFR L858R/T790M と HER2を作用すると、 IC50がそれぞれ0.5 nM, 0.4 nM, 10 nM, 14 nMとなる。
ターゲット

EGFRwt

EGFRL858R

EGFR L858R/T790M

HER2

IC50

0.5 nM

0.4 nM

10 nM

14 nM [1]

In vitro試験 BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
HDLM-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlO1TWM2OD1yLkCwOVczKM7:TR?= MlPDV2FPT0WU
KASUMI-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fiSmlEPTB;MD6wNFkyOSEQvF2= NUD2O|dXW0GQR1XS
HCC2218 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEC5PFch|ryP NUiyb5NyW0GQR1XS
KARPAS-45 M2jjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK0TWM2OD1yLkCxOlcyKM7:TR?= NXzuOVRwW0GQR1XS
HSC-4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;2UWlEPTB;MD6wNVc1QCEQvF2= NXXCdXJiW0GQR1XS
CHL-1 M4XZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi2ZZhKSzVyPUCuNFE5OzlizszN M33HNnNCVkeHUh?=
KY821 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPUTotKSzVyPUCuNFIxPiEQvF2= M4PUfnNCVkeHUh?=
NCI-N87 M4[1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO2RWFKSzVyPUCuNFI4PzNizszN MVzTRW5ITVJ?
DOK NWjIOHNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfkTWM2OD1yLkCzNVk1KM7:TR?= M2K2enNCVkeHUh?=
DSH1 Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMEOzNVQh|ryP MoTiV2FPT0WU
MDA-MB-175-VII NXrtTIxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEO0NVYh|ryP NVjDZWtCW0GQR1XS
NCI-H2170 NV2zVWdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEO3Nlgh|ryP NWjBbHJnW0GQR1XS
BT-474 NWrLS5pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1OxZ2lEPTB;MD6wOFk5PiEQvF2= MmT3V2FPT0WU
EFO-27 NVPO[IhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\HT2lEPTB;MD6wOVE5OiEQvF2= NYnhcIlsW0GQR1XS
NCI-H720 M3HrTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEWzNlUh|ryP MlvzV2FPT0WU
PC-14 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LNZWlEPTB;MD6wOVY3QCEQvF2= NUiw[IR[W0GQR1XS
EC-GI-10 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEW5NVIh|ryP MlTPV2FPT0WU
KYSE-450 NVrId4d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rP[2lEPTB;MD6wOVk4QCEQvF2= MUjTRW5ITVJ?
BPH-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHMRYpKSzVyPUCuNFU6QDhizszN M3nW[nNCVkeHUh?=
NCI-H292 MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLuRotHUUN3ME2wMlA3ODlizszN Mn73V2FPT0WU
H9 NHjJbYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq3SYFKSzVyPUCuNFcyOzJizszN NWrKR5BZW0GQR1XS
NCI-H526 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljwTWM2OD1yLkC3PFI{KM7:TR?= NI\CO2pUSU6JRWK=
NCI-H1623 NV\lXXRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC5TWM2OD1yLkC4NFI2KM7:TR?= NYTzOG5sW0GQR1XS
KYSE-140 MoTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXVTWM2OD1yLkC4N|Mh|ryP M3nDfXNCVkeHUh?=
Ca9-22 Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHUTWM2OD1yLkC4N|U{KM7:TR?= NGewR3JUSU6JRWK=
AU565 M2m1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTWTWM2OD1yLkC4OVA1KM7:TR?= MVHTRW5ITVJ?
ZR-75-30 NGGzZ3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEm1OFUh|ryP MUfTRW5ITVJ?
NCI-H1770 NXPieGNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMUCyPEDPxE1? Mm\PV2FPT0WU
LB2241-RCC NYH5SlRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjsTWM2OD1yLkGwPFg1KM7:TR?= MWfTRW5ITVJ?
CAL-39 Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfSVWlKSzVyPUCuNVE4QTJizszN NVGzUGNEW0GQR1XS
UACC-893 NFnmeWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMUG4PFUh|ryP NFX1cpRUSU6JRWK=
LU-65 NXHaelNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWm3dHBJUUN3ME2wMlEzPjN|IN88US=> MnTKV2FPT0WU
HN M2P1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Hv[WlEPTB;MD6xN|A4PyEQvF2= NITTWYNUSU6JRWK=
TI-73 M{DzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zyRmlEPTB;MD6xOFcyPSEQvF2= M3Hy[HNCVkeHUh?=
KU812 NFmw[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3CTWM2OD1yLkG1OFU3KM7:TR?= NWXiNZBWW0GQR1XS
SW13 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPQVGZKSzVyPUCuNVYzOTZizszN MWrTRW5ITVJ?
BB30-HNC M4TLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm2ZmRKSzVyPUCuNVY2PzZizszN NFT6WWJUSU6JRWK=
HSC-2 NH[5XHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMU[4N|ch|ryP M4fXSXNCVkeHUh?=
BV-173 NHzqemdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIraWI9KSzVyPUCuNVc2QTZizszN MoXnV2FPT0WU
CAL-27 M2Wxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n1e2lEPTB;MD6xO|Y{PiEQvF2= MnXDV2FPT0WU
SBC-1 M1\5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTVb4VKSzVyPUCuNVg6PTlizszN NX3jWVFFW0GQR1XS
CAL-33 NFjMR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPmO|hKSzVyPUCuNlAyQDRizszN M2PPUXNCVkeHUh?=
NCI-H209 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjCV3NkUUN3ME2wMlIxPDZizszN M1LDW3NCVkeHUh?=
COR-L105 NGnBR2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jBO2lEPTB;MD6yNVA5PCEQvF2= NXvGfWZqW0GQR1XS
HSC-3 MmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TueGlEPTB;MD6yNVE6QCEQvF2= MX;TRW5ITVJ?
NCI-H69 M{ftT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXJXnVKSzVyPUCuNlE1PTFizszN NVvVdmtwW0GQR1XS
MOLT-13 NIW3ZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzIO|VWUUN3ME2wMlI{QTd3IN88US=> NXjp[FVtW0GQR1XS
ML-2 M4TxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUS2[|E{UUN3ME2wMlI1QDB{IN88US=> NG\ZcFBUSU6JRWK=
IGROV-1 NXvzeWlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS4TWM2OD1yLkK1PVUzKM7:TR?= NGfpRZRUSU6JRWK=
TK10 MmjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMk[3N|gh|ryP MnnYV2FPT0WU
EoL-1-cell MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonOTWM2OD1yLkK2PFkzKM7:TR?= NVXPblFFW0GQR1XS
HO-1-N-1 M2LrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\r[lFKSzVyPUCuNlc5PTNizszN NYL6PJVCW0GQR1XS
BHY MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\WUWlEPTB;MD6yPFY2PSEQvF2= M1[3THNCVkeHUh?=
LU-139 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m3VWlEPTB;MD6zNFUyKM7:TR?= MWPTRW5ITVJ?
23132-87 NFuyT5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHO4TmlKSzVyPUCuN|E6OjNizszN M2LzbnNCVkeHUh?=
ACHN M2jiU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfObYVoUUN3ME2wMlMyQTl2IN88US=> NUDIRZRbW0GQR1XS
DoTc2-4510 MonGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwM{KyNVkh|ryP MoPKV2FPT0WU
BB65-RCC NIGwTHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zZcWlEPTB;MD6zOFU6OyEQvF2= MnXRV2FPT0WU
HLE MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy2eIdIUUN3ME2wMlM2ODR4IN88US=> NF;LOWFUSU6JRWK=
HCC1419 NGLSWmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILmV2JKSzVyPUCuN|Y1ODhizszN NXXOTZFFW0GQR1XS
A388 M{jlU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwM{[4OVch|ryP MojVV2FPT0WU
NUGC-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\lTWM2OD1yLkO4N|c{KM7:TR?= MYrTRW5ITVJ?
KYSE-180 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkSwTWM2OD1yLkO5NFg6KM7:TR?= MXfTRW5ITVJ?
TE-6 NHnPXHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF2wSY9KSzVyPUCuOFAzPDZizszN M4LacnNCVkeHUh?=
A498 NFXaZ5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwNEC2O|Qh|ryP MomxV2FPT0WU
NCI-H1648 NH71WndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWT2RXhCUUN3ME2wMlQ1OTh{IN88US=> NF;4ZYVUSU6JRWK=
DU-145 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;K[21OUUN3ME2wMlQ1QDN|IN88US=> NHHsUoxUSU6JRWK=
CW-2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HpVGlEPTB;MD60OlkyPCEQvF2= MVfTRW5ITVJ?
A431 MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTmSGp7UUN3ME2wMlQ5OjN|IN88US=> MYTTRW5ITVJ?
SAS M4fxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TOS2lEPTB;MD60PFM6QCEQvF2= MV;TRW5ITVJ?
NCI-H2126 M1m3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUSzcYhRUUN3ME2wMlUyQTJ4IN88US=> M3ziZXNCVkeHUh?=
NCI-H358 NUG3VGRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2e1bGlEPTB;MD61N|IyKM7:TR?= Ml;KV2FPT0WU
FADU MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnBTWM2OD1yLkW0OFA1KM7:TR?= NEn5cW5USU6JRWK=
ACN M{jL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWraUmpMUUN3ME2wMlU2ODl2IN88US=> NEOzdmFUSU6JRWK=
HCC70 MoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfnNJZKSzVyPUCuOVc3PjFizszN MnLqV2FPT0WU
NCI-H1838 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHSOHhCUUN3ME2wMlYxOjl7IN88US=> MnK4V2FPT0WU
CAL-54 NGPvTmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrSfo1kUUN3ME2wMlYyPjJzIN88US=> MoHrV2FPT0WU
NCI-H1975 M2\hdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIj1RVRKSzVyPUCuOlE4OjhizszN M2TldnNCVkeHUh?=
COR-L88 M17ScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PrTmlEPTB;MD62OFEyOyEQvF2= MknUV2FPT0WU
CTV-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX75dWkxUUN3ME2wMlY1Ozl{IN88US=> M{LoU3NCVkeHUh?=
EW-18 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n1bGlEPTB;MD62PFY6QCEQvF2= NG[2V4tUSU6JRWK=
HCC1806 NEnwWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUm1RnM4UUN3ME2wMlY6PjZ4IN88US=> MXfTRW5ITVJ?
HuP-T4 NG\xWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDkSHNRUUN3ME2wMlY6PzZizszN NIrF[HhUSU6JRWK=
MDA-MB-361 NX7SVJNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;2bmlEPTB;MD63NlY3OiEQvF2= M1XISXNCVkeHUh?=
NCI-H1573 NX\FTWc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjiNplEUUN3ME2wMlc{PjNizszN Ml:wV2FPT0WU
KU-19-19 NIfoSGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jWXmlEPTB;MD63O|Q3PCEQvF2= M3PkcnNCVkeHUh?=
COLO-678 MoDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n3SmlEPTB;MD64NFg{PCEQvF2= MnvHV2FPT0WU
C-33-A NWPGNHZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHyTWM2OD1yLkixNlk4KM7:TR?= NViwWIVbW0GQR1XS
Calu-3 MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXyTWM2OD1yLkixOFM1KM7:TR?= NYjqVFd4W0GQR1XS
AGS NYLqbZhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz2[nNSUUN3ME2wMlg{PjR6IN88US=> MUjTRW5ITVJ?
SCC-25 NHXnVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHRblJSUUN3ME2wMlg1OTdzIN88US=> MXvTRW5ITVJ?
JVM-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M332bWlEPTB;MD64PFI6QSEQvF2= NFPIcFFUSU6JRWK=
HCE-T NGT6SoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MormTWM2OD1yLki4OFI5KM7:TR?= NGrl[VBUSU6JRWK=
ES4 Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[4TWM2OD1yLkm3PFM3KM7:TR?= MUDTRW5ITVJ?
EKVX MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT5TWM2OD1zLkCxNFY1KM7:TR?= MUPTRW5ITVJ?
D-542MG MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjMPYxKSzVyPUGuNFExPjRizszN MmXYV2FPT0WU
SW1116 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPzTWM2OD1zLkCxNlg4KM7:TR?= MoDQV2FPT0WU
5637 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D5fmlEPTB;MT6wNVUyKM7:TR?= MkjvV2FPT0WU
HT-1376 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j4TWlEPTB;MT6wNVUyOyEQvF2= M{fkSXNCVkeHUh?=
NB69 NYSxdXNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljITWM2OD1zLkCyPVQ2KM7:TR?= MojIV2FPT0WU
YKG-1 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3oTWM2OD1zLkC1OFE6KM7:TR?= MXzTRW5ITVJ?
EW-3 NEP3fXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITVU4xKSzVyPUGuNFc5QDNizszN MoXkV2FPT0WU
GCIY M37JbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFwMEixNFQh|ryP MV;TRW5ITVJ?
SK-MES-1 M1zXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFwMUG0PFch|ryP NIr4[pFUSU6JRWK=
PANC-08-13 M4e1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPVWGpnUUN3ME2xMlE3PDF4IN88US=> MnPXV2FPT0WU
SK-NEP-1 NHPHbolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LxTWlEPTB;MT6xO|UyOyEQvF2= NYXmOGlvW0GQR1XS
SW954 NFm2TnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXtbVZ4UUN3ME2xMlIxOjF2IN88US=> Mk[0V2FPT0WU
NCI-SNU-5 NYT5THlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\VPGlEPTB;MT6yN|kh|ryP M1XSXXNCVkeHUh?=
SW48 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDJVmR4UUN3ME2xMlI2PDN{IN88US=> NEixeWhUSU6JRWK=
HT-3 NWrPUI1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7wUphmUUN3ME2xMlI5PzV|IN88US=> MmnIV2FPT0WU
ETK-1 MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf1eVdyUUN3ME2xMlM4PDV4IN88US=> NV;xdW1mW0GQR1XS
SCC-15 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFwM{m0OVEh|ryP NFHORohUSU6JRWK=
DU-4475 M4T3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly4TWM2OD1zLkSwNVIyKM7:TR?= MUTTRW5ITVJ?
NB5 M2TxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPSTWM2OD1zLkSxN|E4KM7:TR?= MXrTRW5ITVJ?
CFPAC-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzUbHAxUUN3ME2xMlQzPDl|IN88US=> MYfTRW5ITVJ?
NCI-H630 NEixeFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS1eoVXUUN3ME2xMlQ2PTh{IN88US=> M3fDRXNCVkeHUh?=
NCI-H82 NGXYNnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;LSW9uUUN3ME2xMlU1ODB4IN88US=> NIfNZnpUSU6JRWK=
ECC10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTFwNUWzOlkh|ryP NF7RVYRUSU6JRWK=
K5 M1PYcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTxTWM2OD1zLkW4N|U4KM7:TR?= MVrTRW5ITVJ?
ME-180 M{jwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH0RmlKSzVyPUGuOlExQTZizszN NHjlfIpUSU6JRWK=
KYSE-410 M1zNZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFwNkW2O|Ih|ryP M4XTU3NCVkeHUh?=
G-401 NEPlPZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHPZVdKSzVyPUGuOlc1OTNizszN NH3mO49USU6JRWK=
TGBC24TKB MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:2VXJHUUN3ME2xMlY5OjNizszN MUnTRW5ITVJ?
Detroit562 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O4U2lEPTB;MT63NFE2OiEQvF2= M3\zXnNCVkeHUh?=
OE19 NUTD[2FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLHTWM2OD1zLkexOVEzKM7:TR?= MmKyV2FPT0WU
CAKI-1 M{Lld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFwN{iyNVEh|ryP Mlf6V2FPT0WU
TE-12 MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn4WolKSzVyPUGuPFA1OTRizszN MmjkV2FPT0WU
NCI-H1666 NUPafo17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnz5TWM2OD1zLkiwPVQ5KM7:TR?= NXnlc4RWW0GQR1XS
TE-1 M{nT[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvpTWM2OD1zLkixOFc2KM7:TR?= Ml7lV2FPT0WU
CAL-12T MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nGXWlEPTB;MT64PFk1PSEQvF2= NYnoeoVRW0GQR1XS
TE-8 NH70PGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDSOXRWUUN3ME2xMlkyOzd5IN88US=> NY\LcpZ3W0GQR1XS
KYSE-270 NGnMW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLrTWM2OD1{LkCyO|MzKM7:TR?= NYDqOIRtW0GQR1XS
GMS-10 MnTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrjRXQ5UUN3ME2yMlA{PTF5IN88US=> NVP6blJmW0GQR1XS
A2780 M1ntTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJwME[yPVQh|ryP NHTPNVNUSU6JRWK=
OMC-1 NGP5NopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TPfWlEPTB;Mj6wPFE3QSEQvF2= MVPTRW5ITVJ?
LoVo M3rCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK4boZKSzVyPUKuNVA4QTdizszN M17DWHNCVkeHUh?=
PANC-03-27 MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJwMU[2N|Eh|ryP MlnXV2FPT0WU
MDA-MB-157 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[0Upk5UUN3ME2yMlIyQDJ6IN88US=> NFXOcItUSU6JRWK=
CaR-1 NFS4clVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJwMkiyPFEh|ryP M3XEZXNCVkeHUh?=
769-P MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJwMkmwN|ch|ryP NX2yUJF3W0GQR1XS
NB7 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3ZXmNtUUN3ME2yMlI6Pjd4IN88US=> MX\TRW5ITVJ?
MKN7 M1fUZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17mbGlEPTB;Mj6zOVM{PSEQvF2= NEjDVG1USU6JRWK=
NCI-H1048 NF;NcYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFewOoxKSzVyPUKuOFkyPThizszN M1jJOXNCVkeHUh?=
RCM-1 M{XNSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL2cW4yUUN3ME2yMlUzQTN6IN88US=> MUPTRW5ITVJ?
HT55 NHzSeWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnFTWM2OD1{LkW3N|gh|ryP Mn75V2FPT0WU
HCC1569 NUjEWW03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzJTWM2OD1{LkW4Nlk4KM7:TR?= MljUV2FPT0WU
LXF-289 NWDofW5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{frfGlEPTB;Mj62N|U3PSEQvF2= M{LGXHNCVkeHUh?=
OVCAR-3 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTaVXFEUUN3ME2yMlY4OTZ5IN88US=> M4LXW3NCVkeHUh?=
TE-10 NXHuXXRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj2eYhLUUN3ME2yMlY5ODd6IN88US=> NX[xT3dTW0GQR1XS
SNU-C2B MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli3TWM2OD1{Lk[4OlE3KM7:TR?= NXW2ZW5NW0GQR1XS
LB1047-RCC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwN{S4PFgh|ryP M2GzT3NCVkeHUh?=
SN12C M2LCfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzOTWM2OD1{LkmxPVY1KM7:TR?= MYDTRW5ITVJ?
786-0 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrudJRKSzVyPUOuNFY1ODhizszN M2PRVnNCVkeHUh?=
HT-29 NH:xbHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj2PGJKSzVyPUOuNFc{ODlizszN MkLZV2FPT0WU
RPMI-7951 NYXKVGptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTNwMEe1PUDPxE1? MnPiV2FPT0WU
NBsusSR NFjwfpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPRVoNKSzVyPUOuNVgzPTRizszN NYn1R2N7W0GQR1XS
NKM-1 NHXCfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPFR403UUN3ME2zMlE5PzR2IN88US=> M1nyUnNCVkeHUh?=
Capan-2 MnvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfCblZKSzVyPUOuOFY5PzVizszN NH;ESZVUSU6JRWK=
MKN1 NWnnSVl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;LT45KSzVyPUOuOFcyODhizszN MV\TRW5ITVJ?
OAW-42 M4jlWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTNwNUCwNlYh|ryP M1v4WHNCVkeHUh?=
SKG-IIIa M1nlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvNfnZKSzVyPUOuOVIzOzdizszN M1\zdHNCVkeHUh?=
no-11 NHO0R25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTNwNUO1OlQh|ryP M3\V[HNCVkeHUh?=
NY NHTJTYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjTRVZKSzVyPUOuOVM3PTVizszN NELPfVJUSU6JRWK=
HEC-1 NV;tbVdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX3cnJKSzVyPUOuOVg6PSEQvF2= MnHUV2FPT0WU
NCI-H441 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTNwNUm4OFEh|ryP NVHLZo9GW0GQR1XS
NCI-H2009 NIXYe5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTNwNkGyNVYh|ryP NGG3bG1USU6JRWK=
T47D NHfw[mNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVruSGxpUUN3ME2zMlYzOjF5IN88US=> NVfQZWJ2W0GQR1XS
SNU-449 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\zN|FKSzVyPUOuOlU5OjZizszN NX\5Rpl1W0GQR1XS
NCI-SNU-1 NV\vOVNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLpN2d2UUN3ME2zMlY6PzN3IN88US=> NGHLRVNUSU6JRWK=
BT-20 NYmzUYhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjB[|JnUUN3ME2zMlY6Pzl3IN88US=> NHvJSZNUSU6JRWK=
LS-123 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvkdmdpUUN3ME2zMlc1Ojh2IN88US=> NVT2eFhYW0GQR1XS
8305C MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLMOpdXUUN3ME2zMlc2QTFzIN88US=> NIXrUVNUSU6JRWK=
OCUB-M NXjIZXB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[3dXhKSzVyPUOuO|YyQDdizszN NVHBV3FQW0GQR1XS
KOSC-2 M2PEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfkTWM2OD1|LkizOFUyKM7:TR?= NV75eHhEW0GQR1XS
NCI-H1693 NHnZXXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTNwOESxPFEh|ryP NIn5OFRUSU6JRWK=
TE-9 NWXuRphYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T4SWlEPTB;Mz64OFM5OiEQvF2= M3TLNXNCVkeHUh?=
MV-4-11 MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTNwOEe5PVQh|ryP MlLLV2FPT0WU
GAMG NHXJRXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XMVGlEPTB;Mz65NVMyPCEQvF2= NIjYVFNUSU6JRWK=
KNS-62 M3nrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\QRppKSzVyPUOuPVQ4OzFizszN M17nb3NCVkeHUh?=
MC116 NYXleFNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTNwOUW0PFkh|ryP MX;TRW5ITVJ?
647-V MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTNwOUi0OVIh|ryP Ml7EV2FPT0WU
U-87-MG NYjBSZFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\HUVlKSzVyPUSuNVA1QDFizszN NIjNWINUSU6JRWK=
RPMI-8226 NHTTUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zU[2lEPTB;ND6xNVY{OSEQvF2= NUXzd|l{W0GQR1XS
SW1417 NIm3d5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHvZmJPUUN3ME20MlEzOTR5IN88US=> M3XXSXNCVkeHUh?=
LAMA-84 NUPrXmkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHwTWM2OD12LkG3NFIh|ryP M33WfXNCVkeHUh?=
LS-513 M3z0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTRwM{GyNVch|ryP NWjTbYpLW0GQR1XS
KLE NXz2dno6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\sRWlEPTB;ND60NFgyQSEQvF2= NWTNRlhjW0GQR1XS
HCT-116 NGjLOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTRwNEGwNFch|ryP NEKxTYxUSU6JRWK=
EPLC-272H NVnIRVFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nsSWlEPTB;ND60NVU{OyEQvF2= NUDLd3Z{W0GQR1XS
KS-1 M{K2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M12yTWlEPTB;ND61NFg5QSEQvF2= MWTTRW5ITVJ?
HT-1197 NYOxWGk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTSTWM2OD12LkWyOlY6KM7:TR?= NH\DOIxUSU6JRWK=
LCLC-97TM1 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojVTWM2OD12LkWzOlg3KM7:TR?= NXro[op5W0GQR1XS
ES5 NF61c4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHjO3JKSzVyPUSuPFM4OjNizszN Mk\3V2FPT0WU
CTB-1 NUXmb21OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrmTWM2OD12Lki0PFgh|ryP MnLGV2FPT0WU
HL-60 MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTRwOE[2NVEh|ryP MkHWV2FPT0WU
VM-CUB-1 NWXQVHFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO0WphKSzVyPUSuPFY5OTlizszN NGntRVBUSU6JRWK=
MEG-01 M2nTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTRwOUm0NFMh|ryP MXjTRW5ITVJ?
KYSE-520 M{jlPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTVwMkC4N|kh|ryP MXjTRW5ITVJ?
HuO-3N1 NXLldZBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LMbWlEPTB;NT6yOFA1OyEQvF2= M1zXO3NCVkeHUh?=
SW620 NHyzfFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTVwMkS5OlQh|ryP NUHwSJZGW0GQR1XS
U031 NIqxNWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTVwMkW0NlQh|ryP NF36VXNUSU6JRWK=
TE-5 NVniR4k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTVwNEC4OUDPxE1? M{TkXnNCVkeHUh?=
NCI-H747 NHjmPYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrmTWM2OD13LkSyOFczKM7:TR?= M2G0fXNCVkeHUh?=
MG-63 M3;kNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT1TWM2OD13LkS4O|YzKM7:TR?= M1rMNXNCVkeHUh?=
HC-1 NXL2WnUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojyTWM2OD13LkWxPFM6KM7:TR?= MnXYV2FPT0WU
HCC2998 NV3V[ohuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnlTWM2OD13LkWyOlE2KM7:TR?= M{fpVnNCVkeHUh?=
NTERA-S-cl-D1 NW\aV2ZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDyTWM2OD13LkW0OVM4KM7:TR?= MY\TRW5ITVJ?
KINGS-1 NEP6cIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr4OmRkUUN3ME21MlYxQTR2IN88US=> NGjDZmFUSU6JRWK=
D-423MG NEnERVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LrR2lEPTB;NT62NVcxPSEQvF2= MXXTRW5ITVJ?
SW962 NITRTZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknsTWM2OD13Lk[yNFMzKM7:TR?= M2O1PXNCVkeHUh?=
LOXIMVI NYrh[INST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIGyXWNKSzVyPUWuOlM5PzNizszN NXHtPYlPW0GQR1XS
LS-411N MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLmTWM2OD13Lke5OFQyKM7:TR?= NYm4No9TW0GQR1XS
NCI-H2291 MnjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTVwOUi5OFMh|ryP NVu1WlI1W0GQR1XS
A549 NUHTWJVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LxTmlEPTB;Nj6xNlU2OyEQvF2= Ml7wV2FPT0WU
LS-1034 NWTtSHl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomxTWM2OD14LkKwO|A3KM7:TR?= NY\CWIxWW0GQR1XS
NB14 NF3oem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7MeWNKSzVyPU[uOFM5OzZizszN MUfTRW5ITVJ?
NCI-H1299 M{fCUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PMcmlEPTB;Nj62N|E4OSEQvF2= MXPTRW5ITVJ?
BT-549 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTZwNk[4PFkh|ryP Mkn1V2FPT0WU
J-RT3-T3-5 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTZwOE[5JO69VQ>? MYnTRW5ITVJ?
SW756 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfWTWM2OD14LkmxNVc3KM7:TR?= Mn32V2FPT0WU
DJM-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTZwOUKwNVIh|ryP NGfyOW5USU6JRWK=
GP5d NVXqUpNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInQNZhKSzVyPU[uPVc{QTRizszN MnHiV2FPT0WU
MOLT-4 NI\GPFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTdwMEKxN|Uh|ryP NGXPb4NUSU6JRWK=
NCI-H28 NWDN[VRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3xV2hLUUN3ME23MlE3PDB3IN88US=> NH\4cJhUSU6JRWK=
MN-60 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnW[mtuUUN3ME23MlI5ODh7IN88US=> MmXLV2FPT0WU
RMG-I MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTdwM{myPVYh|ryP NIizV49USU6JRWK=
COLO-800 M1\I[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\yS2RKSzVyPUeuOFE1PDZizszN NUDsV4g6W0GQR1XS
DB M{\xd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXWcJJMUUN3ME23MlYyODB3IN88US=> NXvZOIs1W0GQR1XS
Ca-Ski Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fjSmlEPTB;Nz62OFI2QSEQvF2= NIXGOIpUSU6JRWK=
HEL NF\yeHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPXe3pKSzVyPUeuO|EzODNizszN NEDPR2dUSU6JRWK=
NH-12 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3HTWM2OD15LkeyPFA5KM7:TR?= MljUV2FPT0WU
LB373-MEL-D MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PocmlEPTB;Nz63Olc4OSEQvF2= NWDYUHlNW0GQR1XS
SW900 M2rQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTdwOEKxNlEh|ryP NILURWdUSU6JRWK=
JVM-3 NVzGWm8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvifmJKSzVyPUeuPFk2QTlizszN MoK5V2FPT0WU
OAW-28 NYTjVlM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTdwOUS1O|gh|ryP MlK4V2FPT0WU
KURAMOCHI NUTBWIczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHncVdiUUN3ME23Mlk1QDFzIN88US=> MoLaV2FPT0WU
BE-13 NX\1PGs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPa[Yk1UUN3ME23Mlk5OTF{IN88US=> M4jyRnNCVkeHUh?=
VMRC-RCZ MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\qUXNZUUN3ME24MlAyPjl5IN88US=> MX;TRW5ITVJ?
NCI-H727 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRThwMUC0NkDPxE1? NFTlSYJUSU6JRWK=
SW1710 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPBTWM2OD16LkG4OVE2KM7:TR?= MmDxV2FPT0WU
D-502MG MnTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnpcHNKSzVyPUiuNlkzQDJizszN NF3BXIdUSU6JRWK=
NCI-H1993 NXTYclZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRThwM{O2N|Eh|ryP MoWzV2FPT0WU
SCC-4 NGO0TVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2m3SmlEPTB;OD60OFA2QSEQvF2= MoDYV2FPT0WU
HAL-01 NUjaR4k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXmflI3UUN3ME24MlUyQTFizszN NEfPSVJUSU6JRWK=
GT3TKB NF7XfWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjhNolsUUN3ME24MlY4QTZ2IN88US=> M1\v[XNCVkeHUh?=
SK-OV-3 NXTKUXlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTyTWM2OD16LkexN|I6KM7:TR?= MXvTRW5ITVJ?
COLO-829 NGfhTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rDOGlEPTB;OD64NFk4PiEQvF2= MkOwV2FPT0WU
OCI-AML2 NXnmbIZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTPb|lKSzVyPUiuPVU1QDFizszN NXS2RXdRW0GQR1XS
OS-RC-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXCTWM2OD17LkCyNVkh|ryP MWjTRW5ITVJ?
BFTC-909 MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn0TWM2OD17LkC2O|k6KM7:TR?= M3\SOHNCVkeHUh?=
EW-11 NGTafZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTlwMUe2OVMh|ryP Mn;FV2FPT0WU
HCE-4 NUfZbJlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{KxTGlEPTB;OT6yNVU2QCEQvF2= NY\ucYI1W0GQR1XS
BALL-1 NF71UWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTNUZcxUUN3ME25MlIyQTB5IN88US=> M4LlT3NCVkeHUh?=
SF539 NHfZR3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTlwMkO1OlIh|ryP NInuc5BUSU6JRWK=
CAMA-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfpUZFKSzVyPUmuNlgyOjhizszN NYfiOlJWW0GQR1XS
C32 NIXOUmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfZcHVkUUN3ME25MlM{ODZ2IN88US=> NYSzUHNUW0GQR1XS
NCI-H1703 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTlwM{SzO|Uh|ryP NVLrdldzW0GQR1XS
NCI-H1650 NInaRYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rsc2lEPTB;OT62NFk1PiEQvF2= MWnTRW5ITVJ?
NCI-H1563 NIjNOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTYNXlTUUN3ME25Mlc3ODNzIN88US=> MlzyV2FPT0WU
CAL-85-1 M4\TVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEewcYRKSzVyPUmuPFc{QDNizszN NWqzbpBXW0GQR1XS
UM-UC-3 M2POV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrEdJdKSzVyPUmuPVUxOyEQvF2= NVXUN21MW0GQR1XS
BxPC-3 NYfP[5BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvrOXpSUUN3ME2xNE4xQTd{IN88US=> M1jIc3NCVkeHUh?=
MHH-PREB-1 NIfSZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTFyLkG5PVkh|ryP M4PHfXNCVkeHUh?=
DEL MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TYfGlEPTB;MUCuN|k1PiEQvF2= M2L0OHNCVkeHUh?=
HuCCT1 MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j1[GlEPTB;MUCuOlA{OyEQvF2= NUXSPVk6W0GQR1XS
OVCAR-4 M2fldmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Ta[2lEPTB;MUCuPFg{PSEQvF2= NH33Z2RUSU6JRWK=
CAL-72 NHL0VZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDsTWM2OD1zMD65N|kyKM7:TR?= MXfTRW5ITVJ?
HCC1954 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTFzLkC3OVQh|ryP NV\TfIpyW0GQR1XS
EFO-21 M{LkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTFzLkGwOFUh|ryP NIrhSFVUSU6JRWK=
FTC-133 M2rGPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTFzLkG0NFch|ryP M1rFbnNCVkeHUh?=
SK-MEL-24 NVzGUpFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTFzLkKzOlYh|ryP MYDTRW5ITVJ?
UACC-62 MlzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPRcm5KSzVyPUGxMlI{PjhizszN M4HFTnNCVkeHUh?=
NCI-H650 M3LhdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWmy[4QyUUN3ME2xNU4zPDF6IN88US=> MYfTRW5ITVJ?
ALL-PO M17i[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC2cmZKSzVyPUGxMlI2OTJizszN MWTTRW5ITVJ?
T84 NY\nN5M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDsdJFKSzVyPUGxMlM6ODdizszN MWXTRW5ITVJ?
IST-MEL1 NHfvNYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTFzLkS1OVkh|ryP MUXTRW5ITVJ?
SW626 NEO1NlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTFzLkW3OVUh|ryP NGDNVpRUSU6JRWK=
RPMI-2650 NIDMSJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4W2RmlEPTB;MUGuOVg5PSEQvF2= MoDDV2FPT0WU
MC-IXC NXHvbHBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nnSGlEPTB;MUGuOlczQCEQvF2= NFOwbXNUSU6JRWK=
HOP-62 NV\OcWpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG0V3NKSzVyPUGxMlY4PjRizszN MXvTRW5ITVJ?
NOS-1 NYjNV2tpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm0WmZxUUN3ME2xNU44OTB7IN88US=> MnvOV2FPT0WU
SW1573 MonOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFzLkeyPVUh|ryP MmnRV2FPT0WU
WM-115 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTFzLke1PFgh|ryP NIrQZWxUSU6JRWK=
HuO9 NUDN[pd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fGbWlEPTB;MUGuPFc4PCEQvF2= MknvV2FPT0WU
YAPC Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTFzLkmyOVkh|ryP NHnOSJdUSU6JRWK=
MDA-MB-453 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFzLkm1NVUh|ryP NIDTdmFUSU6JRWK=
NCI-H596 M2D6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3vTWM2OD1zMj6wN|Y6KM7:TR?= MlLtV2FPT0WU
A172 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLzSG02UUN3ME2xNk4xPzl6IN88US=> M1qxNXNCVkeHUh?=
RS4-11 M2rLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFj6NndKSzVyPUGyMlE4OjVizszN NX\uNGRLW0GQR1XS
HCC1937 M{XvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL2coI{UUN3ME2xNk44PTZ2IN88US=> NH7E[3JUSU6JRWK=
SW837 Mln0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTF{LkmwNlgh|ryP NYL2[WN1W0GQR1XS
NMC-G1 M4DKfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m5UWlEPTB;MUKuPVI{PCEQvF2= NXjWXFJyW0GQR1XS
PFSK-1 NXnZdJV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWm4dng6UUN3ME2xN{4xPiEQvF2= NIDGe4tUSU6JRWK=
DBTRG-05MG MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYH4flBLUUN3ME2xN{4xPjN{IN88US=> MmW4V2FPT0WU
SK-UT-1 NVGzb|l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTF|LkGwPFMh|ryP NIfCT41USU6JRWK=
OVCAR-5 M4Pkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGC5XmVKSzVyPUGzMlE2QTNizszN MXXTRW5ITVJ?
8505C NWDVd4tTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHywTJpKSzVyPUGzMlIxPjdizszN M3zCRXNCVkeHUh?=
SK-MEL-1 NVjaclU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rQT2lEPTB;MUOuO|E{PSEQvF2= M4\Q[XNCVkeHUh?=
LK-2 NFLZUnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojOTWM2OD1zMz63OlM6KM7:TR?= M1nBd3NCVkeHUh?=
OE33 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW5TWM2OD1zMz63PFYh|ryP NH\YWXVUSU6JRWK=
Ramos-2G6-4C10 MlfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHLNIF1UUN3ME2xOE4xOjB{IN88US=> MXXTRW5ITVJ?
EW-13 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLKTWM2OD1zND6wN|UzKM7:TR?= MnzvV2FPT0WU
NCI-H1793 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF2zeoZKSzVyPUG0MlIxQDdizszN MYrTRW5ITVJ?
BHT-101 MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPyTWM2OD1zND6yOFEh|ryP NWDOT3RkW0GQR1XS
RKO MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzZTWM2OD1zND61NFc2KM7:TR?= MW\TRW5ITVJ?
NEC8 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\B[3BKSzVyPUG0MlU1PzJizszN NWTHNJhuW0GQR1XS
PANC-10-05 MlTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\xSGlCUUN3ME2xOE43OjR5IN88US=> NUDRbG1sW0GQR1XS
NCI-H2030 MmnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF2Lk[0OFgh|ryP MYTTRW5ITVJ?
C2BBe1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HO[mlEPTB;MUSuO|Y1KM7:TR?= Mo\TV2FPT0WU
EM-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:yXmlEPTB;MUSuPFU4PiEQvF2= MX;TRW5ITVJ?
HCC1395 M1XDS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Pu[2lEPTB;MUSuPVM{QCEQvF2= NIHU[WVUSU6JRWK=
A2058 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX0TWM2OD1zNT6wOFA6KM7:TR?= NW\RWotRW0GQR1XS
SW1463 NX;afoZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzsZoRKSzVyPUG1MlA1QDVizszN MXXTRW5ITVJ?
J82 NWq2VmMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF3LkC1O{DPxE1? MX3TRW5ITVJ?
CAL-120 MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\WNYg2UUN3ME2xOU4yPDR5IN88US=> MVvTRW5ITVJ?
COLO-824 Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nz[GlEPTB;MUWuNVU4QSEQvF2= MnXxV2FPT0WU
LNCaP-Clone-FGC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTF3LkSyOFgh|ryP MUDTRW5ITVJ?
CP66-MEL MlLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DZN2lEPTB;MUWuOFY5QCEQvF2= Mn;xV2FPT0WU
OC-314 M1LuT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV31bWp7UUN3ME2xOU41PzF2IN88US=> NHfrfmNUSU6JRWK=
OVCAR-8 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzWcotvUUN3ME2xOU45QDZzIN88US=> MnfSV2FPT0WU
MFE-280 MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHudolKSzVyPUG2MlA1QDhizszN NGPpXJZUSU6JRWK=
MHH-NB-11 MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnW2TWM2OD1zNj6wPFM6KM7:TR?= NHLRZZFUSU6JRWK=
SW1990 NELHe|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;ZWoFTUUN3ME2xOk4yPzV3IN88US=> MY\TRW5ITVJ?
U-266 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTF4LkKyPVkh|ryP NF7KXZZUSU6JRWK=
MFM-223 M2m4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPPV5dtUUN3ME2xOk4{QTZ3IN88US=> MYDTRW5ITVJ?
L-363 M2PlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvadlg6UUN3ME2xOk41PTd5IN88US=> MW\TRW5ITVJ?
MCF7 MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULuZZM4UUN3ME2xOk41PzJ|IN88US=> MonUV2FPT0WU
SK-MEL-3 NWe2S5RST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq1c5lDUUN3ME2xOk41Pzh5IN88US=> NUXxbpA{W0GQR1XS
HH NYjtW5NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj1WWxTUUN3ME2xOk42OTZ{IN88US=> NFrQfIFUSU6JRWK=
no-10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPt[XpKSzVyPUG2MlY{PDNizszN M2XWRnNCVkeHUh?=
HuP-T3 NV\aUlJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHXcG9EUUN3ME2xOk43PTd4IN88US=> MU\TRW5ITVJ?
QIMR-WIL M{jEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jmZWlEPTB;MU[uO|ExPSEQvF2= M1;uTnNCVkeHUh?=
NCI-H1092 NG\CfGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{m2eGlEPTB;MU[uPFMyPiEQvF2= M1HvUHNCVkeHUh?=
MZ2-MEL NG\KNXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e1eGlEPTB;MU[uPFQxOyEQvF2= NW\he|Z5W0GQR1XS
ES3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXNTWM2OD1zNj65NVM1KM7:TR?= NIi5flVUSU6JRWK=
COLO-684 NYfaZ4l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTF4Lkm0O|ch|ryP NVn6b2tqW0GQR1XS
NCI-H661 NITlS5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnBbGpKSzVyPUG2Mlk3QTRizszN M1fuSHNCVkeHUh?=
CP50-MEL-B M2PhUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17sWmlEPTB;MUeuNFM1OyEQvF2= MVPTRW5ITVJ?
NCI-H2405 NY\jcGhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjQTWM2OD1zNz6xPVc1KM7:TR?= NVfnTIlFW0GQR1XS
U-2-OS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknKTWM2OD1zNz61N|A4KM7:TR?= NELXW2NUSU6JRWK=
RERF-LC-MS NX[0VW15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n6dWlEPTB;MUeuOVUxQCEQvF2= M{[wO3NCVkeHUh?=
NCI-H2342 NEnudVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\3[2lEPTB;MUeuOVU4KM7:TR?= NH\RclZUSU6JRWK=
ES8 NGW1[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTF5Lk[wPFch|ryP NX[yT5F4W0GQR1XS
MOLT-16 NGfzOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1X5RmlEPTB;MUeuPFk{PCEQvF2= NVnCVGxGW0GQR1XS
RH-18 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF6LkCwN|Uh|ryP MlnHV2FPT0WU
D-283MED NYKxOoZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\NTWM2OD1zOD6wNFg5KM7:TR?= NFfOc4dUSU6JRWK=
RCC10RGB MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nlNGlEPTB;MUiuNFU2QSEQvF2= MYPTRW5ITVJ?
NCI-H1437 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjyTWM2OD1zOD6xOlQyKM7:TR?= M2nmdnNCVkeHUh?=
SW982 MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTHTWM2OD1zOD6yOlcyKM7:TR?= M1fpdXNCVkeHUh?=
IST-MES1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\UTWM2OD1zOD60OFI5KM7:TR?= NVPpTW5[W0GQR1XS
A704 NG\CSndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTGepJKSzVyPUG4MlQ4PTNizszN MmLHV2FPT0WU
ESS-1 MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXJTWM2OD1zOD61NlA2KM7:TR?= MYHTRW5ITVJ?
SCH NGDsbIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTF6Lk[0OVYh|ryP MlPMV2FPT0WU
COLO-320-HSR NEPGbYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX2[WFKSzVyPUG4Mlc1PiEQvF2= NIjMdGlUSU6JRWK=
Mo-T M1LUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDrVm51UUN3ME2xPE45OjB2IN88US=> NU\aWJJJW0GQR1XS
Saos-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTF7LkGxOlIh|ryP NVjyN24zW0GQR1XS
SW684 M1G2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PmeWlEPTB;MUmuNVMzPiEQvF2= Mk\MV2FPT0WU
KMOE-2 MmnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF7LkKyOFIh|ryP NIPJU|dUSU6JRWK=
MMAC-SF MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HvVmlEPTB;MUmuNlYxPyEQvF2= M1nQVXNCVkeHUh?=
JAR MofQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:3[GlEPTB;MUmuNlk6KM7:TR?= MYrTRW5ITVJ?
SK-MEL-28 NGjkbm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF7LkOzOlMh|ryP M{n3NXNCVkeHUh?=
KNS-81-FD NILkVYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDIXZdKSzVyPUG5MlU1PjhizszN NWjKVJYyW0GQR1XS
ES7 MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnW[I5KSzVyPUG5MlYzQTJizszN NITy[GlUSU6JRWK=
AsPC-1 NYjsS2c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXyd2x3UUN3ME2xPU43PDdzIN88US=> Mk\2V2FPT0WU
NCI-H1155 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;HTWM2OD1zOT63NlM5KM7:TR?= MUfTRW5ITVJ?
KYSE-510 NFjtT2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\xTWM2OD1zOT64O|Q5KM7:TR?= MVLTRW5ITVJ?
ES1 MnLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\mTWM2OD1zOT65NlE{KM7:TR?= NXzYXHViW0GQR1XS
PC-3 M2f5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nsc2lEPTB;MUmuPVYxPCEQvF2= MWHTRW5ITVJ?
GCT MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;KTWM2OD1{MD6zNFI3KM7:TR?= NEXRdIRUSU6JRWK=
KARPAS-299 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJyLkO0NlIh|ryP NIrqN2lUSU6JRWK=
DOHH-2 M4DvSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJyLkW0OlMh|ryP M{nOPHNCVkeHUh?=
COLO-741 NFq4OItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm0OGdxUUN3ME2yNE43PiEQvF2= MlvkV2FPT0WU
NCI-H1395 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\MfYdKSzVyPUKwMlY3QTdizszN NWX4SHRQW0GQR1XS
HCC1187 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJyLk[3N|Qh|ryP NYH6NVlLW0GQR1XS
Becker MnXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPOTWM2OD1{MD63NlAyKM7:TR?= NXLnSINzW0GQR1XS
LU-134-A NFHJPZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPUTWM2OD1{MT6xNFI3KM7:TR?= MY\TRW5ITVJ?
MKN45 NY\rXmJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrPbHJsUUN3ME2yNU4yPTVzIN88US=> M3XO[XNCVkeHUh?=
LC-2-ad Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTiZ4h6UUN3ME2yNU4zPzJ7IN88US=> M4[3bnNCVkeHUh?=
EW-24 NF3ycZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfSTWM2OD1{MT6zPVQ2KM7:TR?= NHrjNm1USU6JRWK=
SK-N-AS M3jleWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vzRWlEPTB;MkGuPFI4PiEQvF2= NWPSV3NXW0GQR1XS
NCI-H2052 M4XzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnBeFVKSzVyPUKxMlg6PjNizszN M3;yd3NCVkeHUh?=
A4-Fuk NELFWmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXpTWM2OD1{Mj6xOFE6KM7:TR?= NVrPZ2p{W0GQR1XS
NB10 NIjaN3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfFOWRtUUN3ME2yNk4zOzdzIN88US=> M{P5cnNCVkeHUh?=
CHP-212 NFnodo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJ{LkOyNlIh|ryP MX;TRW5ITVJ?
KM12 NHvBeHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Tqc2lEPTB;MkKuN|U3KM7:TR?= MY\TRW5ITVJ?
JEG-3 M3Plfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfSdYhRUUN3ME2yNk4{PzhizszN MYHTRW5ITVJ?
LN-405 NEPpfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjQUY9KSzVyPUKyMlU6OTNizszN NIPHPXFUSU6JRWK=
HCT-15 Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ{Lke0OFEh|ryP NVLEbopDW0GQR1XS
MLMA MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[0TWM2OD1{Mj63OFch|ryP M4C1OXNCVkeHUh?=
GI-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJ{Lke2OVgh|ryP MmjXV2FPT0WU
RT-112 M1j4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJ{Lki2NVYh|ryP NXXkdlVMW0GQR1XS
MPP-89 MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILlU2RKSzVyPUKyMlg3PjFizszN MWjTRW5ITVJ?
A3-KAW NUnDOmc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3mTWM2OD1{Mz6xNFA{KM7:TR?= NXS3RlZ[W0GQR1XS
KALS-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjCTWM2OD1{Mz6xOFE1KM7:TR?= NHLDdYxUSU6JRWK=
SF126 NYPMPXdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnsNYVSUUN3ME2yN{43QTJ2IN88US=> NH7O[JhUSU6JRWK=
SiHa NYHiOpdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjFcHJKSzVyPUKzMlk{OjdizszN M3nYfHNCVkeHUh?=
MDA-MB-415 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJ|Lkm0PVkh|ryP MoHXV2FPT0WU
Daoy M{i2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWycZRvUUN3ME2yOE4yOjZizszN M3PVTXNCVkeHUh?=
COR-L23 M3i3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJ2LkG3Olch|ryP NXy0N2ZEW0GQR1XS
KG-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJ2LkG5Nlgh|ryP Mm\UV2FPT0WU
L-428 M1nrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJ2LkW3PVEh|ryP Mn:2V2FPT0WU
NCI-H520 M{T2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjDTWM2OD1{ND64PFYyKM7:TR?= NVLjT5B{W0GQR1XS
COLO-792 Mn3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPNPYhKSzVyPUK1MlI4OzJizszN Mk\KV2FPT0WU
NB12 NWHNN3dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJ3LkK5OFch|ryP NF;FUXpUSU6JRWK=
GAK NWP5OZZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjNTHFKSzVyPUK1MlI6PjNizszN NFjvUJlUSU6JRWK=
SW780 MmnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK3eGxKSzVyPUK1MlMzPjRizszN NF;RcHBUSU6JRWK=
GB-1 NF;jUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\Zb5dKSzVyPUK1MlQxPjlizszN NIW4dGFUSU6JRWK=
P12-ICHIKAWA M3O2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX0TWM2OD1{NT60O|g2KM7:TR?= M{nVfXNCVkeHUh?=
NCI-H1651 NFL4NHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrBe4luUUN3ME2yOU42QTdizszN M1jwdXNCVkeHUh?=
KE-37 M3XtN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\MVWlEPTB;MkWuO|MyPSEQvF2= MoDiV2FPT0WU
CCRF-CEM Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTBTFJKSzVyPUK1Mlk3PyEQvF2= NFexeIhUSU6JRWK=
SF295 M3O1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\iTWM2OD1{Nj6wOFI2KM7:TR?= M1;2[nNCVkeHUh?=
G-361 NGi5eJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf3OXB3UUN3ME2yOk4yODJ5IN88US=> NVzCeJRPW0GQR1XS
HOP-92 NUHiN|R7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTER5JIUUN3ME2yOk4yOjJ4IN88US=> NU[1TXVWW0GQR1XS
UMC-11 NX:4co1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJ4LkS1NVQh|ryP M4XrWHNCVkeHUh?=
IST-SL1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL2TWM2OD1{Nj62OVkyKM7:TR?= NUfoV|ZPW0GQR1XS
TE-11 NXq0XnVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJ4Lke3OVIh|ryP NI\Pfo1USU6JRWK=
NCI-H1304 Mn7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4SzWGlEPTB;Mk[uPVExQCEQvF2= NVXhWWdmW0GQR1XS
SJSA-1 M{LyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrJTWM2OD1{Nz6wNVc3KM7:TR?= MYTTRW5ITVJ?
BCPAP NWrvZ|JkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjGdGdLUUN3ME2yO{4yOzdizszN NV[wT2tyW0GQR1XS
HTC-C3 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXLO3hTUUN3ME2yO{4zPTZzIN88US=> NIrEXYpUSU6JRWK=
EW-16 M{f4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;heGlEPTB;MkeuNlk1PyEQvF2= MWDTRW5ITVJ?
HT-144 MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;KTWM2OD1{Nz60NFMzKM7:TR?= NHW3Z5hUSU6JRWK=
MHH-ES-1 M4jKdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPE[nlKSzVyPUK3MlQ1PDdizszN Ml;oV2FPT0WU
T98G MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEmyZXlKSzVyPUK3MlU5PDZizszN MV7TRW5ITVJ?
RPMI-8866 Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTaTWM2OD1{Nz63OVYzKM7:TR?= NUjyb2VLW0GQR1XS
BEN MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OxXmlEPTB;MkeuPFUyPyEQvF2= NXfK[YVrW0GQR1XS
MDA-MB-231 NVH6Um1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LMR2lEPTB;MkiuNlc6PSEQvF2= M2jWcnNCVkeHUh?=
HuH-7 NVe5U455T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfwNYhpUUN3ME2yPE41ODJ6IN88US=> M2e1R3NCVkeHUh?=
SK-N-FI NFi2W3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJ6LkSzN{DPxE1? Mn;3V2FPT0WU
AN3-CA M3PTcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTJ6LkSzPVUh|ryP Mon0V2FPT0WU
EGI-1 MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvleGlKSzVyPUK4MlU6OjhizszN NH\GN21USU6JRWK=
697 NXH0VmZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJ6Lk[zN|Eh|ryP M{jYNnNCVkeHUh?=
TCCSUP MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP2SI1KSzVyPUK4MlY1OThizszN NEX5NlhUSU6JRWK=
GR-ST MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPSTWM2OD1{OD62Olk3KM7:TR?= NVewcpNiW0GQR1XS
SK-N-DZ MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlriTWM2OD1{OD62PFg2KM7:TR?= MXrTRW5ITVJ?
MIA-PaCa-2 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXpWnhNUUN3ME2yPE44QTV7IN88US=> MWnTRW5ITVJ?
IGR-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrkOXpKSzVyPUK4Mlg5PzRizszN MmTSV2FPT0WU
BFTC-905 NVz0bVduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXZTnl1UUN3ME2yPU4zPzB3IN88US=> MVLTRW5ITVJ?
NCI-H1581 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3qNW1KSzVyPUK5MlMyPDVizszN NGXET4NUSU6JRWK=
RD MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTLRY9KSzVyPUK5MlUzOzNizszN MkHVV2FPT0WU
SF268 NYjTR444T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITkdm1KSzVyPUK5MlU6OzFizszN MYrTRW5ITVJ?
SHP-77 NELKeJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnXT|JSUUN3ME2yPU43OTh{IN88US=> MoDUV2FPT0WU
D-566MG MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DoNmlEPTB;MkmuPVM6OyEQvF2= Ml;WV2FPT0WU
TGBC1TKB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNyLkGyN|gh|ryP Mn;hV2FPT0WU
MEL-HO NGfIfZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL5TWM2OD1|MD6xOFI{KM7:TR?= MVrTRW5ITVJ?
SJRH30 NUf0OJFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLlZY9KSzVyPUOwMlIyODhizszN M{C0enNCVkeHUh?=
D-336MG NHXUcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\FTWM2OD1|MD6yPFkzKM7:TR?= NWnFXXpoW0GQR1XS
C3A MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPYTWM2OD1|MD6yPVI4KM7:TR?= M131VXNCVkeHUh?=
Calu-6 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTBTWM2OD1|MD6yPVY{KM7:TR?= MUfTRW5ITVJ?
MZ1-PC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHYVolKSzVyPUOwMlM6OyEQvF2= NV3aelVjW0GQR1XS
KYSE-70 NUjI[odzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGqwTFBKSzVyPUOwMlUyOTRizszN MonxV2FPT0WU
CAPAN-1 M{i5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNyLkWxPFEh|ryP NVrtOYxlW0GQR1XS
DK-MG NUTseINET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ewRmlEPTB;M{CuOVQ2PiEQvF2= M{C1Z3NCVkeHUh?=
SK-HEP-1 M4jOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3ENW5KSzVyPUOwMlY{OjZizszN MXHTRW5ITVJ?
MS-1 MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNyLki4PFkh|ryP M{fGb3NCVkeHUh?=
GI-ME-N NGT3PZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrm[YpKSzVyPUOxMlA2PzFizszN MXjTRW5ITVJ?
NCI-H510A NVjLXIdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj0[plKSzVyPUOxMlQxODZizszN M3qwRnNCVkeHUh?=
NB17 NUXVV4hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTH[ph7UUN3ME2zNU42OTh3IN88US=> MUnTRW5ITVJ?
639-V MlX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\tPGVGUUN3ME2zNU42OjR|IN88US=> MWDTRW5ITVJ?
CAL-51 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHrTWM2OD1|MT61OlY4KM7:TR?= NIry[mVUSU6JRWK=
HGC-27 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17KV2lEPTB;M{GuOVg4OyEQvF2= NEjpXmRUSU6JRWK=
GOTO MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLQTWM2OD1|MT64OVA3KM7:TR?= Ml;TV2FPT0WU
ChaGo-K-1 MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPtbZU{UUN3ME2zNk4xODdizszN NIPrSYpUSU6JRWK=
RO82-W-1 NXLZSoNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7aTWM2OD1|Mj6xOlA1KM7:TR?= NFPMcFZUSU6JRWK=
SH-4 MnzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTN{LkG4OVgh|ryP M{PIZXNCVkeHUh?=
A204 NHS1folIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NICxbmJKSzVyPUOyMlUxPjlizszN M1zxTnNCVkeHUh?=
DMS-273 M{LxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fUXGlEPTB;M{KuOVMzOiEQvF2= M2\TSHNCVkeHUh?=
KGN Ml7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTTe2NKSzVyPUOyMlY{OyEQvF2= NF\SUZBUSU6JRWK=
SK-MEL-2 M2DyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrvTWM2OD1|Mj62OVI4KM7:TR?= MV;TRW5ITVJ?
NCI-H2228 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4H6XmlEPTB;M{KuOlYxOiEQvF2= M4XiXnNCVkeHUh?=
MKN28 NWHWbJRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTN{Lke4N|gh|ryP MmjZV2FPT0WU
H-EMC-SS NWq0Z2FiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrSSGRKSzVyPUOyMlk3PzhizszN MX3TRW5ITVJ?
ATN-1 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTN|LkG0NVYh|ryP NVn3WIoyW0GQR1XS
D-263MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTN|LkizO|gh|ryP M3WwRnNCVkeHUh?=
LU-135 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHyzPZRKSzVyPUOzMlg5OjlizszN NXjwOFV4W0GQR1XS
C8166 MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33Mc2lEPTB;M{OuPFg2PCEQvF2= M4TDe3NCVkeHUh?=
T-24 MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPtd|FKSzVyPUO0MlAzODVizszN MWnTRW5ITVJ?
Mewo MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPRO5JuUUN3ME2zOE4yOzR7IN88US=> MVXTRW5ITVJ?
22RV1 M3\y[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrETWM2OD1|ND6xO|U1KM7:TR?= NEPxNmJUSU6JRWK=
KM-H2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLZTWM2OD1|ND6xO|c6KM7:TR?= NIG5NJpUSU6JRWK=
NCI-H2122 MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nU[GlEPTB;M{SuN|Q4OSEQvF2= M2m4dnNCVkeHUh?=
ABC-1 MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPzNJQ3UUN3ME2zOE4{Pjl|IN88US=> MVnTRW5ITVJ?
NCI-H1355 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTN2LkO4PFkh|ryP M{LnW3NCVkeHUh?=
NOMO-1 NUS3bWdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXxTWM2OD1|ND61O|A{KM7:TR?= MVzTRW5ITVJ?
MZ7-mel Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfIZmJIUUN3ME2zOE43PDh5IN88US=> Ml\FV2FPT0WU
NCI-H810 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HvR2lEPTB;M{SuO|I4QCEQvF2= NVzGRlZ3W0GQR1XS
D-392MG M17JbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n6bWlEPTB;M{WuNFU3PSEQvF2= NGrWOXRUSU6JRWK=
LB771-HNC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{La[GlEPTB;M{WuNVY2QCEQvF2= MUXTRW5ITVJ?
COLO-679 MkiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;jTWM2OD1|NT6zPFgh|ryP MnjvV2FPT0WU
SK-PN-DW Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTN3LkSzOlkh|ryP NF7BVFFUSU6JRWK=
VA-ES-BJ MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTN3LkS2OFkh|ryP NWPOZ2FXW0GQR1XS
KNS-42 MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPxeGJKSzVyPUO1MlU5OjZizszN M{PDfnNCVkeHUh?=
RVH-421 NYjjWXlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HuVWlEPTB;M{WuO|Y1PSEQvF2= M1W2THNCVkeHUh?=
P30-OHK NG\4THVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXLTGFKSzVyPUO1Mlg4PTJizszN NGDIXYlUSU6JRWK=
G-402 NIOzNYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jTemlEPTB;M{WuPVg3PyEQvF2= MX;TRW5ITVJ?
S-117 NGXTUZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4SzVWlEPTB;M{[uN|AxQCEQvF2= NY\CdZlEW0GQR1XS
RXF393 M3L2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDmRlhKSzVyPUO2MlM4QDVizszN NHLZ[5VUSU6JRWK=
LCLC-103H NUXvdI9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF2xflFKSzVyPUO2Mlc5ODNizszN NXq3RVAyW0GQR1XS
U-118-MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrFVnY5UUN3ME2zOk45QDR5IN88US=> MYHTRW5ITVJ?
8-MG-BA MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTN4Lkm0PFMh|ryP MW\TRW5ITVJ?
MFH-ino NULoNmFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHCTWM2OD1|Nz6zN|cyKM7:TR?= NXf1R5hMW0GQR1XS
NCI-H23 NGPOTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3O3TmlEPTB;M{euOFE6PiEQvF2= NF;VXZJUSU6JRWK=
NCI-H446 NILFTHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULROHVsUUN3ME2zO{41QDZ{IN88US=> NIXxVXZUSU6JRWK=
LU-99A NXfablBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTN5LkW3N|Eh|ryP NILtVndUSU6JRWK=
KP-N-YN MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32wUGlEPTB;M{euOlE6PSEQvF2= M2HUcnNCVkeHUh?=
SCC-9 NVfkXWx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTN5Lke4N|gh|ryP NVHBUVc6W0GQR1XS
EFM-19 NIfZSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\S[XpWUUN3ME2zO{44QTZ5IN88US=> MlzXV2FPT0WU
A427 NYn6TJJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTN5LkmxNFch|ryP MYfTRW5ITVJ?
LB831-BLC M3XhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTN6Lk[wN|kh|ryP MoDuV2FPT0WU
HOS MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTN7Lk[yO|Mh|ryP MXTTRW5ITVJ?
LAN-6 NWDw[JNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1mzT2lEPTB;NECuNFEyOiEQvF2= MkL4V2FPT0WU
U251 NWLKe25bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\DTWM2OD12MD60NFU1KM7:TR?= M3y2b3NCVkeHUh?=
SNU-387 NXjtd4JiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGmzUGlKSzVyPUSwMlQ2PTNizszN NVfnTnlLW0GQR1XS
DMS-79 NWe3PXJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHkTWM2OD12MD61PFg6KM7:TR?= MlHTV2FPT0WU
SK-LU-1 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXvWFVmUUN3ME20NE43PTZ6IN88US=> MXLTRW5ITVJ?
HT MoLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnZTWM2OD12MD62OlM6KM7:TR?= NXj1b|BjW0GQR1XS
KP-N-YS M1XDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\OPGlEPTB;NECuOlc3QCEQvF2= MVTTRW5ITVJ?
DMS-114 M3Xtemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV24W2g4UUN3ME20NE45Ozd2IN88US=> M3vJPHNCVkeHUh?=
HUTU-80 NV;HTYZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjPTWM2OD12MT6wOVY6KM7:TR?= NGi1NIdUSU6JRWK=
ONS-76 MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTRzLkS3NFkh|ryP NHXVUWpUSU6JRWK=
A673 MnnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDP[lBKSzVyPUSxMlUyPTdizszN NEW1elVUSU6JRWK=
HPAF-II NWjTNIZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrEfGxKSzVyPUSxMlY4ODlizszN M2fRSHNCVkeHUh?=
UACC-257 MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7mTWM2OD12MT63N|Y6KM7:TR?= MnS3V2FPT0WU
EW-22 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjsXVJKSzVyPUSxMlg3QTdizszN M1u2eHNCVkeHUh?=
NCI-H1755 NXvHWopST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfUTWM2OD12MT64O|I2KM7:TR?= NIjT[nRUSU6JRWK=
KYSE-150 NFjyTFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O2VGlEPTB;NEKuNVc5OiEQvF2= NWL4fG01W0GQR1XS
CGTH-W-1 NV7YfWpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTR{LkS5OVUh|ryP MoXoV2FPT0WU
NB13 NIWyc|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnYTWM2OD12Mj62NlE4KM7:TR?= MXnTRW5ITVJ?
SW872 Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf6ZYFpUUN3ME20Nk43OzNzIN88US=> NFfheodUSU6JRWK=
KP-4 M3jXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXFOHJKSzVyPUSyMlg5OzJizszN M4XMcnNCVkeHUh?=
HCC38 M2fGWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTR{Lkm2NVgh|ryP MmLZV2FPT0WU
BB49-HNC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrzTWM2OD12Mz6yN|U3KM7:TR?= NWfzVJlMW0GQR1XS
CAL-62 NEnWdHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLBRm5KSzVyPUSzMlQxOjhizszN MX;TRW5ITVJ?
NCI-H2029 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkO0TWM2OD12Mz61OVgyKM7:TR?= MWnTRW5ITVJ?
M14 NWPybIhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3RTWM2OD12ND6xN|MzKM7:TR?= NFHXWZZUSU6JRWK=
COLO-680N M4C1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\4V3RTUUN3ME20OE4{OzlizszN M1P2SHNCVkeHUh?=
Hs-578-T MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zKcWlEPTB;NEWuNFI6PCEQvF2= M2PmNXNCVkeHUh?=
MSTO-211H NXXzVm82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTR3Lkm0PFIh|ryP Mkm0V2FPT0WU
EW-1 M{XyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTR3Lkm2PFkh|ryP NXjBZ4EzW0GQR1XS
SW948 Moi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f5N2lEPTB;NE[uOFQ3OiEQvF2= MXPTRW5ITVJ?
NCI-H460 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjBOIFbUUN3ME20Ok42OjNizszN MXHTRW5ITVJ?
CAS-1 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTR4Lke3NFEh|ryP MlPuV2FPT0WU
TGBC11TKB NWPJS5lNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnDdGlFUUN3ME20O{4yPzd5IN88US=> NX64dJI2W0GQR1XS
HD-MY-Z M3\XXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nHcmlEPTB;NEiuO|g3KM7:TR?= MVTTRW5ITVJ?
NCI-H226 NYLJZ24{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTR7Lke3PFUh|ryP MmPuV2FPT0WU
PA-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PETWlEPTB;NEmuPFM{PSEQvF2= M3Xk[XNCVkeHUh?=
LB2518-MEL MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTR7Lki3NlMh|ryP Ml71V2FPT0WU
A101D NFPZOHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[z[WlEPTB;NEmuPVQzPSEQvF2= MWjTRW5ITVJ?
NCI-H2087 MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTR7Lkm2PFIh|ryP MVfTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]
臨床試験 A Phase II clinical trial of BIBW2992 for the treatment of cancer has been terminated.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

In vitro kinase activity assays The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.

細胞アッセイ:

[1]

細胞株 NSCLC cells
濃度 0-10 μM
反応時間 1 hour
実験の流れ

1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.

動物実験:

[1]

動物モデル Athymic NMRI-nu/nu female mice
製剤 In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
投薬量 20 mg/kg
投与方法 Oral administration

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Afatinib (BIBW2992) SDF
分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 97 mg/mL (199.61 mM)
エタノール 15 mg/mL (30.86 mM)
<1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

カスタマーフィードバック (3)


Click to enlarge
Rating
Source Int J Proteomics, 2011, 2011, 215496. Afatinib (BIBW2992) purchased from Selleck
Method CEER assay
Cell Lines H460/A549/RFU cell lines
Concentrations 0-10 μM
Incubation Time 4 h
Results This data showed that a potent dose-dependent inhibition of the HER1 and HER2 pathways in the HCC827 cells was observed by treatment with BIBW-2992. Other HER1 and/or HER2 pathway-activated cell lines, H1975 and H1650, were likewise had these pathway activations blocked by the treatment with BIBW-2992.

Click to enlarge
Rating
Source Int J Proteomics, 2011, 2011, 215496. Afatinib (BIBW2992) purchased from Selleck
Method Nikon inverted-phase microscope
Cell Lines lung tumor cell lines
Concentrations 0.1/1 µM
Incubation Time two weeks
Results Reduction of cell colony size formation was observed by the treatment with the irreversible HER1/2 inhibitor BIBW-2992 in H1975 and H1650 cells as seen when these cells were grown in an anchorage-dependent manner.

Click to enlarge
Rating
Source Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck
Method Western blot
Cell Lines Breast cancer cells
Concentrations 0-1 nM
Incubation Time 3 h
Results BIBW2992 treatment resulted in a reduction of EGFR phosphorylation in Breast cancer cells.

文献中の引用 (34)

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related EGFR 阻害剤

  • Erlotinib

    Erlotinib is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.

  • Afatinib (BIBW2992) Dimaleate

    Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.

  • Poziotinib (HM781-36B)

    Poziotinib (HM781-36B) is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Phase 2.

  • AZ5104

    AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor. Phase 1.

  • Gefitinib (ZD1839)

    Gefitinib (ZD1839) は、NR6wtEGFRとNR6W細胞のTyr1173、Tyr992、Tyr1173とTyr992のためのEGFR阻害剤で、IC50 がそれぞれ 37 nM、 37nM、 26 nM 、57 nMです。

    Features:A potent EGFR tyrosine kinase inhibitor.

  • Erlotinib HCl (OSI-744)

    Erlotinib HCl (OSI-744)は、2nMのIC50によるHER1/EGFR阻害剤です。

  • Osimertinib (AZD9291)

    AZD9291 is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR, respectively. Phase 3.

  • Lapatinib

    ラパチニブ(Lapatinib Ditosylateの形で使われる)は、有力なEGFRErbB2 阻害剤で、IC50 がそれぞれ 10.8 と 9.2 nMです。

  • AG-490 (Tyrphostin B42)

    AG-490 (Tyrphostin B42)は、EGFRの選択的な阻害剤、ErbB2とJAK2で、IC50 がそれぞれ 0.1 μM、 13.5 μM、 and ~10 μMです。

最近チェックしたアイテム

Tags: Afatinib (BIBW2992)を買う | Afatinib (BIBW2992)供給者 | Afatinib (BIBW2992)を購入する | Afatinib (BIBW2992)費用 | Afatinib (BIBW2992)生産者 | オーダーAfatinib (BIBW2992) | Afatinib (BIBW2992)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ