Afatinib (BIBW2992)

Afatinib (BIBW2992)は不可逆的にEGF受容体/ HER2含むEGF受容体を抑制、 EGFR L858R , EGFR L858R/T790M と HER2を作用すると、 IC50がそれぞれ0.5 nM, 0.4 nM, 10 nM, 14 nMとなる。

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Afatinib (BIBW2992) 化学構造
分子量: 485.94

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Quality Control & MSDS

製品説明

  • Compare EGFR Inhibitors
    EGFR製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法
  • Afatinib (BIBW2992)のメカニズム

製品の説明

生物活性

製品説明 Afatinib (BIBW2992)は不可逆的にEGF受容体/ HER2含むEGF受容体を抑制、 EGFR L858R , EGFR L858R/T790M と HER2を作用すると、 IC50がそれぞれ0.5 nM, 0.4 nM, 10 nM, 14 nMとなる。
ターゲット

EGFRwt

EGFRL858R

EGFR L858R/T790M

HER2

IC50

0.5 nM

0.4 nM

10 nM

14 nM [1]

In vitro試験 BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
HDLM-2 NHzGfmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PwT2lEPTB;MD6wNFU4OiEQvF2= M2HTeHNCVkeHUh?=
KASUMI-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XBZ2lEPTB;MD6wNFkyOSEQvF2= NYDXd3A{W0GQR1XS
HCC2218 Mmq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7qT4ZmUUN3ME2wMlAxQTh5IN88US=> MXrTRW5ITVJ?
KARPAS-45 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHmTWM2OD1yLkCxOlcyKM7:TR?= NF3LT2pUSU6JRWK=
HSC-4 M{[1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2n1RmlEPTB;MD6wNVc1QCEQvF2= NG[ybpFUSU6JRWK=
CHL-1 NWm0V3R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPyUWxKSzVyPUCuNFE5OzlizszN NW[1[5B{W0GQR1XS
KY821 MkH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEKwOkDPxE1? NFr1XItUSU6JRWK=
NCI-N87 NF;XVI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ntbGlEPTB;MD6wNlc4OyEQvF2= MVrTRW5ITVJ?
DOK NV3qe5FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPLe|k{UUN3ME2wMlA{OTl2IN88US=> NUWyTW1SW0GQR1XS
DSH1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7jfYdUUUN3ME2wMlA{OzF2IN88US=> MUfTRW5ITVJ?
MDA-MB-175-VII NHri[mRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XlSmlEPTB;MD6wN|QyPiEQvF2= M2jyW3NCVkeHUh?=
NCI-H2170 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFiyR|VKSzVyPUCuNFM4OjhizszN NH\KS|BUSU6JRWK=
BT-474 M{XEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMES5PFYh|ryP M4H5fnNCVkeHUh?=
EFO-27 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vROWlEPTB;MD6wOVE5OiEQvF2= NYHQXFByW0GQR1XS
NCI-H720 NF\BRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnwTWM2OD1yLkC1N|I2KM7:TR?= Mnn2V2FPT0WU
PC-14 NV7KOFRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nIe2lEPTB;MD6wOVY3QCEQvF2= NVLLeJEyW0GQR1XS
EC-GI-10 M4jzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEW5NVIh|ryP NFLmZ|JUSU6JRWK=
KYSE-450 NI\WfJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPrOJdKSzVyPUCuNFU6PzhizszN NIf0T|BUSU6JRWK=
BPH-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoKwTWM2OD1yLkC1PVg5KM7:TR?= MULTRW5ITVJ?
NCI-H292 NET1bWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfHTJhKSzVyPUCuNFYxQSEQvF2= NH3uSY5USU6JRWK=
H9 M2nuXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjZeZBTUUN3ME2wMlA4OTN{IN88US=> M1LSfnNCVkeHUh?=
NCI-H526 M1zOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfyTWM2OD1yLkC3PFI{KM7:TR?= NYKwSlZ2W0GQR1XS
NCI-H1623 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[2WXlNUUN3ME2wMlA5ODJ3IN88US=> NIjhVZNUSU6JRWK=
KYSE-140 Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEizN{DPxE1? M{jkdHNCVkeHUh?=
Ca9-22 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEizOVMh|ryP MXzTRW5ITVJ?
AU565 NV;k[|B7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnq2TWM2OD1yLkC4OVA1KM7:TR?= NVfSWIV6W0GQR1XS
ZR-75-30 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnXNGpKSzVyPUCuNFk2PDVizszN NFnlWJFUSU6JRWK=
NCI-H1770 NH:yeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPnb2Y6UUN3ME2wMlExOjhizszN MU\TRW5ITVJ?
LB2241-RCC NXnOeIp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMUC4PFQh|ryP MkjJV2FPT0WU
CAL-39 NY\lZnpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMUG3PVIh|ryP MWnTRW5ITVJ?
UACC-893 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;aW2lEPTB;MD6xNVg5PSEQvF2= NIrLO|BUSU6JRWK=
LU-65 M1LQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH5Vm5tUUN3ME2wMlEzPjN|IN88US=> MmXEV2FPT0WU
HN MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rvWWlEPTB;MD6xN|A4PyEQvF2= M4TPfHNCVkeHUh?=
TI-73 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMUS3NVUh|ryP MkTXV2FPT0WU
KU812 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMUW0OVYh|ryP NXfJPWU4W0GQR1XS
SW13 NYnFWIR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXSzNFJyUUN3ME2wMlE3OjF4IN88US=> NEP2dpZUSU6JRWK=
BB30-HNC MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfaRZZIUUN3ME2wMlE3PTd4IN88US=> NH20UXhUSU6JRWK=
HSC-2 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XueWlEPTB;MD6xOlg{PyEQvF2= NVX6PJVWW0GQR1XS
BV-173 NUjh[3dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r1PGlEPTB;MD6xO|U6PiEQvF2= NHfPdI1USU6JRWK=
CAL-27 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjFVGJKSzVyPUCuNVc3OzZizszN MV;TRW5ITVJ?
SBC-1 NWja[21zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTIUYFKUUN3ME2wMlE5QTV7IN88US=> NFr0TIpUSU6JRWK=
CAL-33 NXzHcItyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMkCxPFQh|ryP Mlz0V2FPT0WU
NCI-H209 NHTEPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMkC0OkDPxE1? MVjTRW5ITVJ?
COR-L105 M2XPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3iTWM2OD1yLkKxNFg1KM7:TR?= M3jJUHNCVkeHUh?=
HSC-3 NYTtbpR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC5S|VKSzVyPUCuNlEyQThizszN NIHqd2xUSU6JRWK=
NCI-H69 NYfjOFI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;vZpp5UUN3ME2wMlIyPDVzIN88US=> MlTkV2FPT0WU
MOLT-13 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q5PWlEPTB;MD6yN|k4PSEQvF2= NWnTOnN5W0GQR1XS
ML-2 M3y3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3oV25KSzVyPUCuNlQ5ODJizszN MlfUV2FPT0WU
IGROV-1 M{TrZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHPVJBIUUN3ME2wMlI2QTV{IN88US=> M3\rXHNCVkeHUh?=
TK10 MlrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMk[3N|gh|ryP NEDiVpFUSU6JRWK=
EoL-1-cell Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEC3XlNKSzVyPUCuNlY5QTJizszN M3jnbHNCVkeHUh?=
HO-1-N-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjJ[Y5KSzVyPUCuNlc5PTNizszN NFv3eI5USU6JRWK=
BHY MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW1e3lKSzVyPUCuNlg3PTVizszN MlOyV2FPT0WU
LU-139 NVL4NJF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWj3O5g5UUN3ME2wMlMxPTFizszN NX:1c4hzW0GQR1XS
23132-87 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7XTWM2OD1yLkOxPVI{KM7:TR?= Mln6V2FPT0WU
ACHN MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HnZWlEPTB;MD6zNVk6PCEQvF2= M3jzTHNCVkeHUh?=
DoTc2-4510 NXLWV3pKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwM{KyNVkh|ryP MWDTRW5ITVJ?
BB65-RCC M2iwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzMclc3UUN3ME2wMlM1PTl|IN88US=> M2PnWHNCVkeHUh?=
HLE NHnrZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIT5VHZKSzVyPUCuN|UxPDZizszN Mlu1V2FPT0WU
HCC1419 NV7tV2JZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXoc3hKSzVyPUCuN|Y1ODhizszN NWXlVpYxW0GQR1XS
A388 M1vwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;KNGlEPTB;MD6zOlg2PyEQvF2= NXH5XFROW0GQR1XS
NUGC-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13Ce2lEPTB;MD6zPFM4OyEQvF2= M{HKTXNCVkeHUh?=
KYSE-180 Mmq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXDbmdKSzVyPUCuN|kxQDlizszN M4\GVXNCVkeHUh?=
TE-6 NELHb3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;2XGlEPTB;MD60NFI1PiEQvF2= M33udHNCVkeHUh?=
A498 NH3VTHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT5O28zUUN3ME2wMlQxPjd2IN88US=> MVnTRW5ITVJ?
NCI-H1648 M2PBWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXGTWM2OD1yLkS0NVgzKM7:TR?= MUTTRW5ITVJ?
DU-145 NVP5[GhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwNES4N|Mh|ryP NFnVbpZUSU6JRWK=
CW-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2T3UGlEPTB;MD60OlkyPCEQvF2= MY\TRW5ITVJ?
A431 NHvNV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HMcGlEPTB;MD60PFI{OyEQvF2= NFLyWFBUSU6JRWK=
SAS NVP4OpFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nOZ2lEPTB;MD60PFM6QCEQvF2= MkC2V2FPT0WU
NCI-H2126 NYL6NVF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwNUG5NlYh|ryP MXHTRW5ITVJ?
NCI-H358 M{TGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlruTWM2OD1yLkWzNlEh|ryP MlP4V2FPT0WU
FADU NWTWZYhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfqTWM2OD1yLkW0OFA1KM7:TR?= MkDyV2FPT0WU
ACN NVfXdJFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwNUWwPVQh|ryP NEnadWxUSU6JRWK=
HCC70 NF3sXnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwNUe2OlEh|ryP M1uzRXNCVkeHUh?=
NCI-H1838 MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnSxTWM2OD1yLk[wNlk6KM7:TR?= NFfPNWtUSU6JRWK=
CAL-54 M4CxU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHKTpZKSzVyPUCuOlE3OjFizszN M4rueHNCVkeHUh?=
NCI-H1975 NY\FN2FmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPaNllwUUN3ME2wMlYyPzJ6IN88US=> NUjiNFBXW0GQR1XS
COR-L88 NGPYe4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrVTWM2OD1yLk[0NVE{KM7:TR?= MUDTRW5ITVJ?
CTV-1 M{jOSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\uPVk5UUN3ME2wMlY1Ozl{IN88US=> MUjTRW5ITVJ?
EW-18 Moj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S2[mlEPTB;MD62PFY6QCEQvF2= M1nYfXNCVkeHUh?=
HCC1806 NIn1ephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\BTWM2OD1yLk[5OlY3KM7:TR?= MkXsV2FPT0WU
HuP-T4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPu[29KSzVyPUCuOlk4PiEQvF2= MmDUV2FPT0WU
MDA-MB-361 NXPsRWpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzSR21KSzVyPUCuO|I3PjJizszN MljoV2FPT0WU
NCI-H1573 NFy5S4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3HTYM5UUN3ME2wMlc{PjNizszN NGjyd2lUSU6JRWK=
KU-19-19 NHPC[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwN{e0OlQh|ryP MnfxV2FPT0WU
COLO-678 NEnwNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfTW2l1UUN3ME2wMlgxQDN2IN88US=> MVfTRW5ITVJ?
C-33-A MnTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjWbFRbUUN3ME2wMlgyOjl5IN88US=> Mm\vV2FPT0WU
Calu-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLITWM2OD1yLkixOFM1KM7:TR?= NX\DOVB7W0GQR1XS
AGS MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwOEO2OFgh|ryP MkH1V2FPT0WU
SCC-25 NE\LUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjh[ZU5UUN3ME2wMlg1OTdzIN88US=> NXnVRVhoW0GQR1XS
JVM-2 Mln3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3vd4tKSzVyPUCuPFgzQTlizszN MVPTRW5ITVJ?
HCE-T NV7LVmJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLZTWl2UUN3ME2wMlg5PDJ6IN88US=> NXjGcVJlW0GQR1XS
ES4 NF\lUG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILxbFVKSzVyPUCuPVc5OzZizszN M3nxbXNCVkeHUh?=
EKVX NFy0cXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvyS2FKSzVyPUGuNFExPjRizszN NWixfZZkW0GQR1XS
D-542MG M4myZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TObWlEPTB;MT6wNVA3PCEQvF2= M3LqcXNCVkeHUh?=
SW1116 MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfETWM2OD1zLkCxNlg4KM7:TR?= NGTXPYpUSU6JRWK=
5637 M32zemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYSyUlhmUUN3ME2xMlAyPTFizszN MX;TRW5ITVJ?
HT-1376 M{H5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTFwMEG1NVMh|ryP MnPIV2FPT0WU
NB69 NFnNU5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTFwMEK5OFUh|ryP NHzQW2xUSU6JRWK=
YKG-1 M1fvemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrLe2VvUUN3ME2xMlA2PDF7IN88US=> NXnwNmx6W0GQR1XS
EW-3 MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULR[5BIUUN3ME2xMlA4QDh|IN88US=> NWr4[YM{W0GQR1XS
GCIY MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\QXHE{UUN3ME2xMlA5OTB2IN88US=> NV36PXFRW0GQR1XS
SK-MES-1 M2XSNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTFwMUG0PFch|ryP NVPo[3p1W0GQR1XS
PANC-08-13 MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHEflJKSzVyPUGuNVY1OTZizszN NXzvSFdxW0GQR1XS
SK-NEP-1 NYP5XItYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFwMUe1NVMh|ryP MXrTRW5ITVJ?
SW954 M3;wUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m1WGlEPTB;MT6yNFIyPCEQvF2= MX;TRW5ITVJ?
NCI-SNU-5 MmD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3oc3R2UUN3ME2xMlI{QSEQvF2= NUm2VW9xW0GQR1XS
SW48 NGPoeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfKTWM2OD1zLkK1OFMzKM7:TR?= NF7hVXVUSU6JRWK=
HT-3 MkP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTFwMki3OVMh|ryP M2WzWHNCVkeHUh?=
ETK-1 M4fZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP6TWM2OD1zLkO3OFU3KM7:TR?= MWLTRW5ITVJ?
SCC-15 NFTIVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGroZnBKSzVyPUGuN|k1PTFizszN MUnTRW5ITVJ?
DU-4475 M13FXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXUT4pGUUN3ME2xMlQxOTJzIN88US=> NEKwb4ZUSU6JRWK=
NB5 NYrjeGw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;6T4xzUUN3ME2xMlQyOzF5IN88US=> M{LU[nNCVkeHUh?=
CFPAC-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTFwNEK0PVMh|ryP MoGwV2FPT0WU
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HAL-01 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRThwNUG5NUDPxE1? MmHiV2FPT0WU
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BALL-1 NHG3[ohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf6SVJsUUN3ME25MlIyQTB5IN88US=> M2DDVnNCVkeHUh?=
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CAL-85-1 NYDufVhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTlwOEezPFMh|ryP M2j4N3NCVkeHUh?=
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DEL NELGPYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Lk[GlEPTB;MUCuN|k1PiEQvF2= MV7TRW5ITVJ?
HuCCT1 NY\MUlc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjRZWgxUUN3ME2xNE43ODN|IN88US=> MUXTRW5ITVJ?
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NCI-H650 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLETWM2OD1zMT6yOFE5KM7:TR?= MmLJV2FPT0WU
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HOP-62 M2frUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTFzLk[3OlQh|ryP MkiyV2FPT0WU
NOS-1 Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTlTWM2OD1zMT63NVA6KM7:TR?= NELPTFZUSU6JRWK=
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NCI-H596 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrXfFdNUUN3ME2xNk4xOzZ7IN88US=> NEjYeWNUSU6JRWK=
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PFSK-1 MorFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTF|LkC2JO69VQ>? MV3TRW5ITVJ?
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OVCAR-5 MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW5TWM2OD1zMz6xOVk{KM7:TR?= MmjFV2FPT0WU
8505C NGKwdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF|LkKwOlch|ryP NGDmOlNUSU6JRWK=
SK-MEL-1 NVvhPVRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\2ZW5RUUN3ME2xN{44OTN3IN88US=> NFXVVI1USU6JRWK=
LK-2 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C2XWlEPTB;MUOuO|Y{QSEQvF2= M1nYRnNCVkeHUh?=
OE33 M1n0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn2TWM2OD1zMz63PFYh|ryP MlixV2FPT0WU
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EW-13 NIm3XWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e3fmlEPTB;MUSuNFM2OiEQvF2= MnTCV2FPT0WU
NCI-H1793 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDrUWFKSzVyPUG0MlIxQDdizszN MXjTRW5ITVJ?
BHT-101 NV33VmdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF2LkK0NUDPxE1? NVPmdW9NW0GQR1XS
RKO NX7FR4tqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XBTWlEPTB;MUSuOVA4PSEQvF2= MW\TRW5ITVJ?
NEC8 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnvcpZKSzVyPUG0MlU1PzJizszN MkHLV2FPT0WU
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NCI-H2030 NFTXfZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrrcJBDUUN3ME2xOE43PDR6IN88US=> MVHTRW5ITVJ?
C2BBe1 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF2Lke2OEDPxE1? NHztelBUSU6JRWK=
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A2058 M1jZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\FPJVqUUN3ME2xOU4xPDB7IN88US=> NWPnb3lPW0GQR1XS
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CAL-120 MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe1W4tKSzVyPUG1MlE1PDdizszN M3rad3NCVkeHUh?=
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OVCAR-8 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUOzU2Y6UUN3ME2xOU45QDZzIN88US=> M1vqdnNCVkeHUh?=
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NCI-H1092 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonrTWM2OD1zNj64N|E3KM7:TR?= MkK5V2FPT0WU
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NCI-H2342 NHeyepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTF5LkW1O{DPxE1? NV70XpFRW0GQR1XS
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NCI-H1437 MmnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTF6LkG2OFEh|ryP MVPTRW5ITVJ?
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SCH MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi1XGE2UUN3ME2xPE43PDV4IN88US=> MUHTRW5ITVJ?
COLO-320-HSR MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PEVmlEPTB;MUiuO|Q3KM7:TR?= MX;TRW5ITVJ?
Mo-T NIrhbG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rsR2lEPTB;MUiuPFIxPCEQvF2= MlS0V2FPT0WU
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MMAC-SF Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPZR5BKUUN3ME2xPU4zPjB5IN88US=> Ml;ZV2FPT0WU
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SK-MEL-28 NEjDOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrxS25KSzVyPUG5MlM{PjNizszN MVLTRW5ITVJ?
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NCI-H810 Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnPTWNKSzVyPUO0MlczPzhizszN NFHqcVdUSU6JRWK=
D-392MG M{jYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;sTWM2OD1|NT6wOVY2KM7:TR?= M4TVdHNCVkeHUh?=
LB771-HNC M1K1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN3LkG2OVgh|ryP NGHUWmlUSU6JRWK=
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G-402 M3HC[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LiXmlEPTB;M{WuPVg3PyEQvF2= NVPYfpVuW0GQR1XS
S-117 NUexU5JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnqbWdTUUN3ME2zOk4{ODB6IN88US=> MkOxV2FPT0WU
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LCLC-103H NF65R2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn73TWM2OD1|Nj63PFA{KM7:TR?= MYnTRW5ITVJ?
U-118-MG MoHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYCzWJN{UUN3ME2zOk45QDR5IN88US=> NY\aZ20{W0GQR1XS
8-MG-BA Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TWXGlEPTB;M{[uPVQ5OyEQvF2= MoTnV2FPT0WU
MFH-ino MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml22TWM2OD1|Nz6zN|cyKM7:TR?= NUHYWJR7W0GQR1XS
NCI-H23 NH\SVZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPpXFFKSzVyPUO3MlQyQTZizszN M4LhSXNCVkeHUh?=
NCI-H446 NXjpTYxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzvTWM2OD1|Nz60PFYzKM7:TR?= NVLxRVRYW0GQR1XS
LU-99A M{fKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTPUm1KSzVyPUO3MlU4OzFizszN NVr4XFdqW0GQR1XS
KP-N-YN NUD0ZZozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3Eb5BKSzVyPUO3MlYyQTVizszN NYLHN2VIW0GQR1XS
SCC-9 NH\XeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;Be2VKSzVyPUO3Mlc5OzhizszN NXjZdVVbW0GQR1XS
EFM-19 MoXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rSbmlEPTB;M{euO|k3PyEQvF2= M13aT3NCVkeHUh?=
A427 NF\oPJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ToU2lEPTB;M{euPVExPyEQvF2= MVrTRW5ITVJ?
LB831-BLC NETEUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\PeJQ1UUN3ME2zPE43ODN7IN88US=> MXHTRW5ITVJ?
HOS NX:zRVIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[1[2lEPTB;M{muOlI4OyEQvF2= MYDTRW5ITVJ?
LAN-6 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Lyb2lEPTB;NECuNFEyOiEQvF2= M2nwWXNCVkeHUh?=
U251 MnOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M12zZ2lEPTB;NECuOFA2PCEQvF2= NU\6[oRGW0GQR1XS
SNU-387 NGHufnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzkTWM2OD12MD60OVU{KM7:TR?= NXfKeFF5W0GQR1XS
DMS-79 NVexbYd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETEV3BKSzVyPUSwMlU5QDlizszN MVHTRW5ITVJ?
SK-LU-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTuU4tKSzVyPUSwMlY2PjhizszN MVrTRW5ITVJ?
HT NIfMNGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3SfFBoUUN3ME20NE43PjN7IN88US=> NXPPZ5ZkW0GQR1XS
KP-N-YS MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\RT2lEPTB;NECuOlc3QCEQvF2= NFHmRWxUSU6JRWK=
DMS-114 MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfsTWM2OD12MD64N|c1KM7:TR?= MXzTRW5ITVJ?
HUTU-80 MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTRzLkC1Olkh|ryP MUfTRW5ITVJ?
ONS-76 NVXaTINoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTRzLkS3NFkh|ryP NFvkOIVUSU6JRWK=
A673 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnJS2FKSzVyPUSxMlUyPTdizszN MlTmV2FPT0WU
HPAF-II NIG1SY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTRzLk[3NFkh|ryP MkHjV2FPT0WU
UACC-257 M2PEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi5U5RKSzVyPUSxMlc{PjlizszN NVnldXpPW0GQR1XS
EW-22 NXq5TY5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P6VmlEPTB;NEGuPFY6PyEQvF2= MWfTRW5ITVJ?
NCI-H1755 NWCyeVhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTRzLki3NlUh|ryP MonCV2FPT0WU
KYSE-150 NHXi[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e4WmlEPTB;NEKuNVc5OiEQvF2= M1j2UnNCVkeHUh?=
CGTH-W-1 MojlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PmSmlEPTB;NEKuOFk2PSEQvF2= NHvlV5FUSU6JRWK=
NB13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPEdZZzUUN3ME20Nk43OjF5IN88US=> NWnRVGRNW0GQR1XS
SW872 NEnxVIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvnTWM2OD12Mj62N|MyKM7:TR?= MnTZV2FPT0WU
KP-4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXFTWM2OD12Mj64PFMzKM7:TR?= MnvOV2FPT0WU
HCC38 NFfkeoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j2VGlEPTB;NEKuPVYyQCEQvF2= MoLtV2FPT0WU
BB49-HNC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTR|LkKzOVYh|ryP NVmz[WdnW0GQR1XS
CAL-62 NG\SXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTR|LkSwNlgh|ryP MXrTRW5ITVJ?
NCI-H2029 M4q2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTR|LkW1PFEh|ryP Ml\WV2FPT0WU
M14 M2juPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTR2LkGzN|Ih|ryP NUfXdo9NW0GQR1XS
COLO-680N NID2UYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLLTWM2OD12ND6zN|kh|ryP MXzTRW5ITVJ?
Hs-578-T M1:wRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i5[GlEPTB;NEWuNFI6PCEQvF2= NH25W3RUSU6JRWK=
MSTO-211H NFyxdopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTR3Lkm0PFIh|ryP NX3ze3NlW0GQR1XS
EW-1 NYj2WmRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIqzNHFKSzVyPUS1Mlk3QDlizszN MX\TRW5ITVJ?
SW948 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH6PGpoUUN3ME20Ok41PDZ{IN88US=> MmrDV2FPT0WU
NCI-H460 MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXn2Z25HUUN3ME20Ok42OjNizszN MXjTRW5ITVJ?
CAS-1 Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PIPGlEPTB;NE[uO|cxOSEQvF2= MmLsV2FPT0WU
TGBC11TKB M3\ZZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXDOGVxUUN3ME20O{4yPzd5IN88US=> M3;wZXNCVkeHUh?=
HD-MY-Z NYnuTFQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTH[3lKSzVyPUS4Mlc5PiEQvF2= NFzCOZVUSU6JRWK=
NCI-H226 NFPKVndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTR7Lke3PFUh|ryP M2n6[nNCVkeHUh?=
PA-1 Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3oTWM2OD12OT64N|M2KM7:TR?= NVuxcJJSW0GQR1XS
LB2518-MEL NXnO[HpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTR7Lki3NlMh|ryP Mn3UV2FPT0WU
A101D NWTWSo1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTR7Lkm0NlUh|ryP MofEV2FPT0WU
NCI-H2087 NVjCdWhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHYTWM2OD12OT65OlgzKM7:TR?= NXXZb2g{W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]
臨床試験 A Phase II clinical trial of BIBW2992 for the treatment of cancer has been terminated.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

In vitro kinase activity assays The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.

細胞アッセイ:

[1]

細胞株 NSCLC cells
濃度 0-10 μM
反応時間 1 hour
実験の流れ

1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.

動物実験:

[1]

動物モデル Athymic NMRI-nu/nu female mice
製剤 In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
投薬量 20 mg/kg
投与方法 Oral administration

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Afatinib (BIBW2992) SDF
分子量 485.94
化学式

C24H25ClFN5O3

CAS No. 439081-18-2
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 97 mg/mL (199.61 mM)
エタノール 15 mg/mL (30.86 mM)
<1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose+0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

カスタマーフィードバック (3)


Click to enlarge
Rating
Source Int J Proteomics, 2011, 2011, 215496. Afatinib (BIBW2992) purchased from Selleck
Method CEER assay
Cell Lines H460/A549/RFU cell lines
Concentrations 0-10 μM
Incubation Time 4 h
Results This data showed that a potent dose-dependent inhibition of the HER1 and HER2 pathways in the HCC827 cells was observed by treatment with BIBW-2992. Other HER1 and/or HER2 pathway-activated cell lines, H1975 and H1650, were likewise had these pathway activations blocked by the treatment with BIBW-2992.

Click to enlarge
Rating
Source Int J Proteomics, 2011, 2011, 215496. Afatinib (BIBW2992) purchased from Selleck
Method Nikon inverted-phase microscope
Cell Lines lung tumor cell lines
Concentrations 0.1/1 µM
Incubation Time two weeks
Results Reduction of cell colony size formation was observed by the treatment with the irreversible HER1/2 inhibitor BIBW-2992 in H1975 and H1650 cells as seen when these cells were grown in an anchorage-dependent manner.

Click to enlarge
Rating
Source Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck
Method Western blot
Cell Lines Breast cancer cells
Concentrations 0-1 nM
Incubation Time 3 h
Results BIBW2992 treatment resulted in a reduction of EGFR phosphorylation in Breast cancer cells.

文献中の引用 (34)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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