BI 2536 化学構造
分子量: 521.66

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製品説明

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  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 NHLlSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEC3O|Yh|ryP NYPtZ3Z[W0GQR1XS
ACN MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2CwNGlEPTB;MD6wNFg1OyEQvF2= M{HDcHNCVkeHUh?=
TE-8 NHv1WZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEC5OFEh|ryP NUDyUGtxW0GQR1XS
LC-2-ad MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXUToFKUUN3ME2wMlAyODl|IN88US=> NV3KRY1QW0GQR1XS
ALL-PO NXfKfYxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDlOGRNUUN3ME2wMlAyOyEQvF2= MmP5V2FPT0WU
EW-16 MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofiTWM2OD1yLkCxN|M3KM7:TR?= MVzTRW5ITVJ?
KM12 MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXwZXZJUUN3ME2wMlAyOzR6IN88US=> MkSwV2FPT0WU
GI-1 NYTjdJRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjlXmY1UUN3ME2wMlAyOzh|IN88US=> M4PLcnNCVkeHUh?=
LS-411N NELKN3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnYW|lKSzVyPUCuNFE1ODdizszN M2HhdXNCVkeHUh?=
ES8 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXyxb2w1UUN3ME2wMlAyPDl2IN88US=> NYTyVnlbW0GQR1XS
SNU-C2B MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PaU2lEPTB;MD6wNVUzPiEQvF2= M2n0fXNCVkeHUh?=
CESS NFXJd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzEUGcyUUN3ME2wMlAyPjB{IN88US=> MYXTRW5ITVJ?
697 MnvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[zfXZKSzVyPUCuNFE3PjhizszN M{PKUXNCVkeHUh?=
NCI-H1963 NXnZd5ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\PbIRKSzVyPUCuNFE3PzNizszN NFS5eohUSU6JRWK=
IA-LM NYTz[lU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEG2PFgh|ryP NGDF[o9USU6JRWK=
SW954 M4iycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEG3NFUh|ryP M1jGW3NCVkeHUh?=
RL95-2 M2jqV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMEG3N|gh|ryP M1\KUnNCVkeHUh?=
LXF-289 NG[zNHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXHTWM2OD1yLkCxO|ch|ryP NX3RNo5yW0GQR1XS
OCUB-M MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfIb5gyUUN3ME2wMlAyQDJ4IN88US=> MULTRW5ITVJ?
RKO MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUmwOFFCUUN3ME2wMlAyQTh5IN88US=> M320UnNCVkeHUh?=
LOUCY MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPkR|BWUUN3ME2wMlAzODVizszN NWHCWVNsW0GQR1XS
NOS-1 M4HDUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVH2R3ljUUN3ME2wMlAzODl|IN88US=> M1r0SXNCVkeHUh?=
A4-Fuk MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnv5TWM2OD1yLkCyNlE5KM7:TR?= MkHMV2FPT0WU
A388 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXQS|lKSzVyPUCuNFIzOjdizszN MY\TRW5ITVJ?
TE-9 NYG1R2RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DPeGlEPTB;MD6wNlI3OSEQvF2= NFr5UIdUSU6JRWK=
KURAMOCHI MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLveZZKSzVyPUCuNFIzQDVizszN NFzwNXNUSU6JRWK=
KALS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fUXmlEPTB;MD6wNlM{QCEQvF2= NHnYNIVUSU6JRWK=
HOP-62 NV;UTWdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHxXVlKSzVyPUCuNFI1OiEQvF2= MmTRV2FPT0WU
RPMI-8402 NHzr[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnqTWM2OD1yLkCyOVA5KM7:TR?= NGjnXI9USU6JRWK=
TE-1 NVK4TFNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEK1NVIh|ryP MkX4V2FPT0WU
CCRF-CEM NH7BNm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jQUmlEPTB;MD6wNlU1OyEQvF2= NEThe5JUSU6JRWK=
HUTU-80 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWmz[4JuUUN3ME2wMlAzPjJ2IN88US=> M1vxXnNCVkeHUh?=
NCI-H1648 Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEK2OFch|ryP NXfTbnBZW0GQR1XS
HCE-4 M4fT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TwZmlEPTB;MD6wNlY5OiEQvF2= NITKTXNUSU6JRWK=
ETK-1 M4W4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTQdWxKSzVyPUCuNFI4OzZizszN MlHUV2FPT0WU
TE-15 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEK3N|gh|ryP NVXJV2p3W0GQR1XS
BE-13 NULQNJVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMEK3OEDPxE1? NX7GOFdSW0GQR1XS
KE-37 MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\TXWlEPTB;MD6wNlc1OSEQvF2= NGntR4ZUSU6JRWK=
NCI-H1355 NXOzZnJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H5WmlEPTB;MD6wNlc5OyEQvF2= M{\lV3NCVkeHUh?=
TE-11 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDETWM2OD1yLkCyPFA6KM7:TR?= M2HBRXNCVkeHUh?=
BL-70 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDSTWM2OD1yLkCyPFU4KM7:TR?= NHSyWGVUSU6JRWK=
ES6 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEK4PFEh|ryP MW\TRW5ITVJ?
GT3TKB NG\kTnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEK5OVMh|ryP NVvqeI1PW0GQR1XS
LB647-SCLC Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnNUVNoUUN3ME2wMlA{OTl3IN88US=> Mnz3V2FPT0WU
NB13 M32xTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfqTWM2OD1yLkCzN|E3KM7:TR?= MnLSV2FPT0WU
ST486 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rCdmlEPTB;MD6wN|M{PyEQvF2= MUHTRW5ITVJ?
NCI-H82 NH7qXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;tTWM2OD1yLkCzN|Q{KM7:TR?= NXvEbHUyW0GQR1XS
NTERA-S-cl-D1 Mk\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv1TWM2OD1yLkCzN|k6KM7:TR?= MUfTRW5ITVJ?
ES4 NYr6XZZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEO0OlMh|ryP NWfTTYFbW0GQR1XS
SK-NEP-1 NVrWc|NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvYPFhKSzVyPUCuNFM1QTlizszN MYrTRW5ITVJ?
Becker M{\DeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGWzPGlKSzVyPUCuNFM2PTVizszN MmP1V2FPT0WU
A101D NGrrfotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTRRYhKSzVyPUCuNFM4PDhizszN MmfTV2FPT0WU
SK-UT-1 NX[wS2VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnQW5NKSzVyPUCuNFM4PzRizszN MYrTRW5ITVJ?
SW982 MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HvUWlEPTB;MD6wN|c6KM7:TR?= NVe4cW82W0GQR1XS
TE-10 NVHFVJU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPTTWM2OD1yLkC0NFQ3KM7:TR?= NVPzdFV3W0GQR1XS
OVCAR-4 M3TFbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHjdWRKSzVyPUCuNFQxPTlizszN NIWweW9USU6JRWK=
KP-N-YS NYTqNYY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMESwPFUh|ryP MnnaV2FPT0WU
BL-41 MoH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\XTWM2OD1yLkC0NVI2KM7:TR?= NYLDenlRW0GQR1XS
MZ1-PC NWDwT4NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLETWM2OD1yLkC0NVI4KM7:TR?= M1zCXHNCVkeHUh?=
PF-382 NFy2UmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH2dppKSzVyPUCuNFQyQThizszN M2TqWHNCVkeHUh?=
MOLT-13 M1;6[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\JTWM2OD1yLkC0NlM5KM7:TR?= M33ZTnNCVkeHUh?=
HCC1599 MnfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PjS2lEPTB;MD6wOFI2QCEQvF2= MmfQV2FPT0WU
IST-MEL1 NHjpflRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMES0OFIh|ryP NX7rOJd5W0GQR1XS
LU-139 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrkPWxKSzVyPUCuNFQ1PDJizszN MXfTRW5ITVJ?
MS-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn62TWM2OD1yLkC0O|AyKM7:TR?= NX7VTplIW0GQR1XS
MFH-ino M3TXR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK0bIdKSzVyPUCuNFUxODNizszN MUfTRW5ITVJ?
IMR-5 NH7VSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTQeGRmUUN3ME2wMlA2ODJzIN88US=> NX33bXNnW0GQR1XS
TE-5 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlWxTWM2OD1yLkC1NFY{KM7:TR?= NWCzN4x4W0GQR1XS
DJM-1 M2[zbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13VdGlEPTB;MD6wOVE1OiEQvF2= NEnzVnNUSU6JRWK=
NB17 MkXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\PTWM2OD1yLkC1NlA4KM7:TR?= NIrPeJVUSU6JRWK=
KARPAS-45 NIrPeo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjBXXRKSzVyPUCuNFU{PThizszN M1rSR3NCVkeHUh?=
TGBC1TKB M1LqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn3PYlKSzVyPUCuNFU1ODVizszN NHn4OWZUSU6JRWK=
ML-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknBTWM2OD1yLkC1OFE1KM7:TR?= NF3xeHZUSU6JRWK=
no-10 NH;ORoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDpN2dKSzVyPUCuNFU1PzRizszN M4\HcnNCVkeHUh?=
CTV-1 NWrvcpRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYSyT2lZUUN3ME2wMlA2PTB{IN88US=> NFvUU4hUSU6JRWK=
SJSA-1 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfUTHJKSzVyPUCuNFU2OiEQvF2= MWDTRW5ITVJ?
HC-1 M3fFWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP3[otmUUN3ME2wMlA2PTl5IN88US=> NX3yN20{W0GQR1XS
TE-12 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDSTWM2OD1yLkC1OlE{KM7:TR?= NXfa[IRlW0GQR1XS
KY821 M4nudGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLTTWM2OD1yLkC1OlMzKM7:TR?= NYDFU442W0GQR1XS
TALL-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfUXFRKSzVyPUCuNFU4ODhizszN M4O0SHNCVkeHUh?=
DEL Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEW3NFkh|ryP MojzV2FPT0WU
TE-6 M4D0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3Ge|RrUUN3ME2wMlA2PzJ{IN88US=> M3jWcHNCVkeHUh?=
SK-LMS-1 M3TjVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DucGlEPTB;MD6wOVgxPSEQvF2= MUfTRW5ITVJ?
EW-1 NXTINXN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LrRmlEPTB;MD6wOVg{PyEQvF2= M4DkTXNCVkeHUh?=
8-MG-BA NYLC[|hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLLTWM2OD1yLkC1PFUyKM7:TR?= MkP3V2FPT0WU
NALM-6 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEW5O|Mh|ryP MmrlV2FPT0WU
LB771-HNC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTaTWM2OD1yLkC1PVc6KM7:TR?= M4jhfHNCVkeHUh?=
HT-144 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTJS|Y2UUN3ME2wMlA3OTNizszN MnTkV2FPT0WU
KM-H2 NITrbopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwME[yNlEh|ryP MXvTRW5ITVJ?
SF268 NITSUHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHjdHJbUUN3ME2wMlA3Ojh4IN88US=> NXnhV4h5W0GQR1XS
RS4-11 M4rlWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7oW45IUUN3ME2wMlA3OzB2IN88US=> M4jN[XNCVkeHUh?=
MHH-PREB-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwME[zNVkh|ryP NGfHS2pUSU6JRWK=
ATN-1 NYXNflAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;qTWM2OD1yLkC2N|Q2KM7:TR?= MnrGV2FPT0WU
BB30-HNC NYTsVYM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2SyWGlEPTB;MD6wOlQ{PiEQvF2= MVvTRW5ITVJ?
CPC-N MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPLNIFbUUN3ME2wMlA3PTJ2IN88US=> NFvUVWFUSU6JRWK=
NB1 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f1cGlEPTB;MD6wOlYyOyEQvF2= NIW1XlJUSU6JRWK=
KS-1 M{TVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPpTWM2OD1yLkC2O|Q5KM7:TR?= NYnXeG1WW0GQR1XS
RXF393 M3ThXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnVelM3UUN3ME2wMlA3PzZ2IN88US=> M1TZVnNCVkeHUh?=
IST-SL2 NXHRco12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEewNFQh|ryP NG\qUW5USU6JRWK=
GI-ME-N MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7i[mJKSzVyPUCuNFczQDZizszN M{PmU3NCVkeHUh?=
VA-ES-BJ MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLHTWM2OD1yLkC3OFc2KM7:TR?= Mlf5V2FPT0WU
NCI-H1581 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPr[3FjUUN3ME2wMlA4PDd6IN88US=> MXXTRW5ITVJ?
U-266 NGX6WHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEe0PVch|ryP MonNV2FPT0WU
DMS-114 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfYb4ZKSzVyPUCuNFc2OjhizszN M1K5XnNCVkeHUh?=
NCI-H187 NEfsc29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES4UI5KSzVyPUCuNFc4OjZizszN MX;TRW5ITVJ?
SW962 Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEe4N|kh|ryP MUHTRW5ITVJ?
MONO-MAC-6 MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjXfppXUUN3ME2wMlA4QTh4IN88US=> MYPTRW5ITVJ?
MOLT-16 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEixNlEh|ryP MWXTRW5ITVJ?
KNS-42 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TxcGlEPTB;MD6wPFE3OSEQvF2= NUX5OWM2W0GQR1XS
CMK MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlmxTWM2OD1yLkC4NlI2KM7:TR?= MmrMV2FPT0WU
Ramos-2G6-4C10 NGjOXpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7EWoxKSzVyPUCuNFgzOjVizszN NXv3WnR[W0GQR1XS
Daudi MmqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHTRWtKSzVyPUCuNFgzPTZizszN NEjNUHBUSU6JRWK=
NCI-H510A MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS1TWM2OD1yLkC4N|M3KM7:TR?= MVLTRW5ITVJ?
LB831-BLC NEj0[YVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\Md456UUN3ME2wMlA5PTZzIN88US=> MWTTRW5ITVJ?
HEL NH\S[WlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDqcpdKSzVyPUCuNFg3PjhizszN MYHTRW5ITVJ?
LU-134-A MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEi3NFgh|ryP NWTnS|ljW0GQR1XS
NCI-H1694 NGflRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIGzO5lKSzVyPUCuNFg4PDRizszN NFW0cldUSU6JRWK=
KGN MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TGfWlEPTB;MD6wPFc2QSEQvF2= NY\ISXlRW0GQR1XS
A253 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHvVFlKSzVyPUCuNFg5OjJizszN Mn3WV2FPT0WU
DG-75 NXOxZmdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrxWFVGUUN3ME2wMlA5QTJ{IN88US=> MXjTRW5ITVJ?
MOLT-4 MkL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnmTWM2OD1yLkC4PVg{KM7:TR?= NES5Wo5USU6JRWK=
NCI-SNU-5 M3i4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XFc2lEPTB;MD6wPVI2QCEQvF2= NIS4Z25USU6JRWK=
ONS-76 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L5V2lEPTB;MD6wPVI4PiEQvF2= NWjDenF4W0GQR1XS
NCI-H446 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33wUWlEPTB;MD6wPVQ3OiEQvF2= MVHTRW5ITVJ?
COR-L279 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1WzdmlEPTB;MD6wPVU2PiEQvF2= M17RWXNCVkeHUh?=
Calu-6 NVzSOoZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jjV2lEPTB;MD6wPVU6QCEQvF2= MnHEV2FPT0WU
BC-3 NG[xUpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH22UFVKSzVyPUCuNFk3PjJizszN M{S2R3NCVkeHUh?=
NCI-H2126 NGXWdo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\2[oRKSzVyPUCuNFk4QTFizszN MXzTRW5ITVJ?
NCI-H1882 M2P3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXrZWJKSzVyPUCuNFk5ODlizszN MWLTRW5ITVJ?
BB65-RCC MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvVOo9KSzVyPUCuNVAzQTRizszN NGjYRVlUSU6JRWK=
DU-4475 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMUC0NFch|ryP MX3TRW5ITVJ?
NCI-H526 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTBS4NKSzVyPUCuNVA1PCEQvF2= MlGyV2FPT0WU
NEC8 NYX3S4Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMUC1NlUh|ryP MXrTRW5ITVJ?
NCI-H1304 MoXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\1OXpoUUN3ME2wMlExPTl2IN88US=> MYXTRW5ITVJ?
L-540 M4jIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LMRWlEPTB;MD6xNFcxQCEQvF2= M3\JTXNCVkeHUh?=
NCI-SNU-16 NUG4cmxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jQOGlEPTB;MD6xNFc1OiEQvF2= M1\uV3NCVkeHUh?=
HD-MY-Z NFXPUFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PmSGlEPTB;MD6xNFg2PiEQvF2= NYjrVY1UW0GQR1XS
K-562 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMUC4OVgh|ryP NH3xO4pUSU6JRWK=
JAR NFjzclBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nN[GlEPTB;MD6xNFkzPSEQvF2= M1;jO3NCVkeHUh?=
MZ2-MEL M3vI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\kZ2NKSzVyPUCuNVExPSEQvF2= NHrTTplUSU6JRWK=
L-363 Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzLepRKSzVyPUCuNVExPzlizszN NIK5foVUSU6JRWK=
BV-173 M4f3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X3OGlEPTB;MD6xNVI1OyEQvF2= MlHuV2FPT0WU
NCI-H524 NX:4TlR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWKzRYU5UUN3ME2wMlEyOjd2IN88US=> NGSzbVVUSU6JRWK=
EoL-1-cell MmfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPYTWM2OD1yLkGxOlczKM7:TR?= NV2ydZhZW0GQR1XS
K052 NYmzWpd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMUG3NVIh|ryP NVvUNIpjW0GQR1XS
TK10 MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDGTWM2OD1yLkGxO|I5KM7:TR?= NV3pOZR7W0GQR1XS
KU812 M2XCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7sTmpKSzVyPUCuNVIxPDRizszN NWrLTZR4W0GQR1XS
RPMI-8226 M3nNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDQPYE4UUN3ME2wMlEzODV{IN88US=> NFjsfFVUSU6JRWK=
MZ7-mel M1;Ye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rZcmlEPTB;MD6xNlI{PyEQvF2= NFHHUYpUSU6JRWK=
SK-PN-DW NV76TWk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zhcmlEPTB;MD6xNlI5PyEQvF2= M3m3NHNCVkeHUh?=
SR NUnOOnNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMUK0OFEh|ryP MWPTRW5ITVJ?
RPMI-6666 M1K4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULvN5pKUUN3ME2wMlEzPzR|IN88US=> MYLTRW5ITVJ?
no-11 NGLVVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LEUGlEPTB;MD6xNlg3QSEQvF2= NEGxXYdUSU6JRWK=
EW-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMUK4PVMh|ryP NUPaVpZNW0GQR1XS
LAMA-84 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHxVXp6UUN3ME2wMlE{OTh5IN88US=> MX7TRW5ITVJ?
HT NYO4XJgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXxbHpzUUN3ME2wMlE{PTd2IN88US=> NXLqeo9LW0GQR1XS
KP-N-RT-BM-1 NGDh[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHNdHVKSzVyPUCuNVM3OTJizszN MVPTRW5ITVJ?
NCI-H747 NFjlSItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK3[nRKSzVyPUCuNVM4KM7:TR?= MX3TRW5ITVJ?
NCCIT NEi1dYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zHO2lEPTB;MD6xN|k{QSEQvF2= NXfWUm5DW0GQR1XS
MLMA MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fqXWlEPTB;MD6xOFE3PyEQvF2= Mk\tV2FPT0WU
LP-1 M1niV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr5R2FKSzVyPUCuNVQzPCEQvF2= MX3TRW5ITVJ?
CAL-148 MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMUS0PFMh|ryP M2G1OHNCVkeHUh?=
GB-1 MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4flV2lEPTB;MD6xOFUzPiEQvF2= MXnTRW5ITVJ?
COR-L88 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHlT4RKSzVyPUCuNVQ5ODJizszN NGLwRWFUSU6JRWK=
NKM-1 M2HTe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLZeIhGUUN3ME2wMlE1QTB4IN88US=> NFXodHlUSU6JRWK=
NB5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTx[ZVKSzVyPUCuNVU1PjJizszN NFy3NWFUSU6JRWK=
SH-4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMUW0OlYh|ryP NVG0S2NCW0GQR1XS
EM-2 M4Hk[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG0SZJKSzVyPUCuNVU1PjdizszN M4DTbnNCVkeHUh?=
TGBC24TKB MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TqUWlEPTB;MD6xOVY2QSEQvF2= MXrTRW5ITVJ?
SCLC-21H MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf4eG9CUUN3ME2wMlE2PzB{IN88US=> NXHSeG82W0GQR1XS
COLO-684 NHjPTHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLkTWM2OD1yLkG1O|IyKM7:TR?= NV\qeoFuW0GQR1XS
KINGS-1 M4TLNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXHTWM2OD1yLkG1PVEh|ryP NGfQWJlUSU6JRWK=
LS-123 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMUW5NVch|ryP M{e1UXNCVkeHUh?=
MC116 M2HJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf0OVVVUUN3ME2wMlE3OTV6IN88US=> NH;ReGpUSU6JRWK=
SU-DHL-1 NXXKZ4NtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTZZmRzUUN3ME2wMlE3OjB4IN88US=> MVXTRW5ITVJ?
NCI-H64 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XySGlEPTB;MD6xOlM1PyEQvF2= NYPxfW83W0GQR1XS
HCE-T NEnz[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknPTWM2OD1yLkG2OVA1KM7:TR?= MnHrV2FPT0WU
LOXIMVI M1zOeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMU[5OFkh|ryP M1rjRnNCVkeHUh?=
ARH-77 M4nuTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD3TVlsUUN3ME2wMlE4Ozd7IN88US=> MnzxV2FPT0WU
DOHH-2 NXXGRmQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMUe2O|Ih|ryP M2q5fXNCVkeHUh?=
COLO-320-HSR M3zse2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPWSm9KSzVyPUCuNVgyPTRizszN NHLR[25USU6JRWK=
NB6 NYD1OFFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XrZWlEPTB;MD6xPFU3PiEQvF2= MkjTV2FPT0WU
L-428 M2f5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMUi4NVMh|ryP MYXTRW5ITVJ?
SNB75 M4XyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4GwWGlEPTB;MD6xPFgzPCEQvF2= Mlq1V2FPT0WU
NCI-H2141 NFrL[|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXyN4o6UUN3ME2wMlE6ODFzIN88US=> NF3NXlBUSU6JRWK=
KARPAS-299 M1fpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTBbFdKSzVyPUCuNVkzPDFizszN NEfWNJlUSU6JRWK=
LC4-1 MmjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMUm1NFIh|ryP M1TTOnNCVkeHUh?=
UACC-257 NYjUdmp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP6b3dKSzVyPUCuNVk6PDdizszN MljrV2FPT0WU
EVSA-T M2iyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i5fWlEPTB;MD6yNFMyOiEQvF2= M1HjfnNCVkeHUh?=
JiyoyeP-2003 MkniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTqTWM2OD1yLkKwOFc4KM7:TR?= MW\TRW5ITVJ?
NCI-H720 M1voOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\HTWM2OD1yLkKwOVI2KM7:TR?= MoXsV2FPT0WU
GAK MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[4XlR5UUN3ME2wMlIyOTh7IN88US=> NXS3coVGW0GQR1XS
HH NH3Q[WlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInEZZRKSzVyPUCuNlE1ODVizszN MnLHV2FPT0WU
NCI-H1436 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMkG0OlQh|ryP M{PBcHNCVkeHUh?=
GR-ST M{XRVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXS5WY9QUUN3ME2wMlIyPDh6IN88US=> M4PJWXNCVkeHUh?=
BC-1 M13jUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMkK2NVYh|ryP NWPq[5RJW0GQR1XS
SIG-M5 NI\0b5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLnTWM2OD1yLkKyO|I4KM7:TR?= Mn:1V2FPT0WU
NCI-H345 M1jiNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnv[XE6UUN3ME2wMlI{QDB3IN88US=> NGDhUG5USU6JRWK=
OPM-2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fYN2lEPTB;MD6yN|g5OiEQvF2= MkTQV2FPT0WU
LB1047-RCC MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XhT2lEPTB;MD6yOFQyKM7:TR?= M{O2fXNCVkeHUh?=
CTB-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMkS0PVMh|ryP MXzTRW5ITVJ?
A3-KAW NIXaN3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TmfWlEPTB;MD6yOVM1OSEQvF2= NIX6fGZUSU6JRWK=
SF126 MoTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\iTWM2OD1yLkK1N|g{KM7:TR?= NFnrR25USU6JRWK=
KARPAS-422 M2fiOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jtUGlEPTB;MD6yOVQ{PSEQvF2= NXz3XWxGW0GQR1XS
MEG-01 M17lPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\0WWlEPTB;MD6yOVY4OyEQvF2= NWrWW4czW0GQR1XS
NCI-H209 M2XkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUGwe3BOUUN3ME2wMlI3Ozd2IN88US=> MlzlV2FPT0WU
SBC-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMk[1JO69VQ>? NWDOR3VIW0GQR1XS
K5 M2n6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjqTGc3UUN3ME2wMlI3QTh2IN88US=> NEHsRlhUSU6JRWK=
QIMR-WIL NW\SS|FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfzb5hKSzVyPUCuNlcyPTVizszN NEjTdlJUSU6JRWK=
NMC-G1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMkiyNVch|ryP NID3ZnVUSU6JRWK=
IST-MES1 M3HNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\XbnRKSzVyPUCuNlkzOzhizszN M2XUN3NCVkeHUh?=
SW684 NITyc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSyTWM2OD1yLkOwNFQ4KM7:TR?= M1HLNXNCVkeHUh?=
MV-4-11 NUTWV3NpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwM{C3PFgh|ryP MVjTRW5ITVJ?
LAN-6 NUTQTHRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HwT2lEPTB;MD6zNVU4OiEQvF2= NHHFb4JUSU6JRWK=
RH-1 Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrHb|FXUUN3ME2wMlMyQDdzIN88US=> MlLWV2FPT0WU
CP66-MEL NWK0PWhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPDTWM2OD1yLkOxPFc5KM7:TR?= MWTTRW5ITVJ?
EC-GI-10 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Hid2lEPTB;MD6zNlk5PyEQvF2= MmjQV2FPT0WU
GDM-1 M3zz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwM{OwOVkh|ryP NV:1cFJpW0GQR1XS
IST-SL1 NIjVeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwM{S5NVQh|ryP M1zV[XNCVkeHUh?=
KMOE-2 M{fDdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPBfYlKSzVyPUCuN|UyPzVizszN NXf0NpRwW0GQR1XS
OS-RC-2 NEfXVmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwM{W1OFQh|ryP M2e5[nNCVkeHUh?=
HDLM-2 NV;ZTmtLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M322WWlEPTB;MD6zO|gyPCEQvF2= NI\0PYlUSU6JRWK=
DSH1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3WZWVKSzVyPUCuN|g3OzFizszN NYG2TJNEW0GQR1XS
LS-1034 MljXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\mTWM2OD1yLkO4PVU1KM7:TR?= MVrTRW5ITVJ?
LB373-MEL-D MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn3c2VKSzVyPUCuN|kyQTdizszN NG\2dY1USU6JRWK=
GOTO MnXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;GTWM2OD1yLkSyNVE5KM7:TR?= MmnWV2FPT0WU
MRK-nu-1 Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\HXWlEPTB;MD60NlIxPSEQvF2= NVf2VlZPW0GQR1XS
SK-MM-2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3WxNmlEPTB;MD60N|Q1OiEQvF2= M4Xjc3NCVkeHUh?=
BOKU NH;tW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TDdGlEPTB;MD60N|c6OiEQvF2= NEm0Z25USU6JRWK=
NOMO-1 NULNNmM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\zUmlEPTB;MD60N|g3KM7:TR?= MWPTRW5ITVJ?
J-RT3-T3-5 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LkcmlEPTB;MD60OFg4QCEQvF2= Mnz0V2FPT0WU
COLO-668 M3y5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjWRW1KSzVyPUCuOFU3PjhizszN M13FcXNCVkeHUh?=
SF539 M{npS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXXTWM2OD1yLkS4Olg1KM7:TR?= NX3GSoJlW0GQR1XS
LB2518-MEL NH;BV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPQTWM2OD1yLkS5O|A{KM7:TR?= MYnTRW5ITVJ?
TE-441-T MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwNUCxNkDPxE1? NUjPXohvW0GQR1XS
MDA-MB-134-VI Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH6TWM2OD1yLkWwPVIyKM7:TR?= NXLseJVyW0GQR1XS
SCC-3 NUn0WJJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrETWM2OD1yLkWxPFc{KM7:TR?= Mle0V2FPT0WU
KLE NX24c3RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwNUKxO|Eh|ryP NImzR|JUSU6JRWK=
LB2241-RCC Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\tTWM2OD1yLkWyOVI2KM7:TR?= MYHTRW5ITVJ?
NCI-H1417 NVLuXFh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwNUO0N|Uh|ryP MoXIV2FPT0WU
NCI-H2081 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XDd2lEPTB;MD61PFYyOSEQvF2= MoPaV2FPT0WU
NCI-H1522 NYDJfVNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfvbmJWUUN3ME2wMlU6Ozh|IN88US=> M3jybHNCVkeHUh?=
NCI-H889 NX;4NYdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNUm4OFQh|ryP MUjTRW5ITVJ?
CGTH-W-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P3[WlEPTB;MD62NFc2PSEQvF2= NWDJcJM{W0GQR1XS
EB-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3MTWM2OD1yLk[xNVU{KM7:TR?= NHfZXZVUSU6JRWK=
D-336MG NYrhVWs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH4fYhmUUN3ME2wMlYyPzlzIN88US=> MW\TRW5ITVJ?
LC-1F MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn1[XdmUUN3ME2wMlYzPTl{IN88US=> NYS0WVA3W0GQR1XS
MHH-NB-11 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkK3TWM2OD1yLk[zPFAyKM7:TR?= NXi4VVg4W0GQR1XS
SK-N-FI M3PIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfYTWM2OD1yLk[zPVEh|ryP M{XnXnNCVkeHUh?=
NCI-H69 M1rrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlm4TWM2OD1yLk[0PFc6KM7:TR?= NWKwWY1jW0GQR1XS
SCH NETmVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnB[Gw3UUN3ME2wMlY3ODJ|IN88US=> NH;aV|VUSU6JRWK=
LS-513 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwNkeyOVkh|ryP MYfTRW5ITVJ?
CP67-MEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorpTWM2OD1yLk[3OVk3KM7:TR?= NV\F[XpvW0GQR1XS
GCIY MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G5[2lEPTB;MD63NFM3OyEQvF2= MlrBV2FPT0WU
SHP-77 M3POU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XlRmlEPTB;MD63NFc{PCEQvF2= M2OxZ3NCVkeHUh?=
EHEB Ml2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYftRm45UUN3ME2wMlcyQDV2IN88US=> NGTj[m5USU6JRWK=
D-247MG M2Xw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzjUoxbUUN3ME2wMlc{OjN{IN88US=> MVzTRW5ITVJ?
Raji NH\IVmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XNeGlEPTB;MD63OFk5QSEQvF2= MXXTRW5ITVJ?
MPP-89 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\0UoppUUN3ME2wMlc2QTd6IN88US=> NGjIR3RUSU6JRWK=
EKVX NGW5fZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LuS2lEPTB;MD63PVA4OyEQvF2= NIjkbY5USU6JRWK=
HCC2218 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwN{mxN|Eh|ryP NFPTdWxUSU6JRWK=
KNS-81-FD MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwOEGwNVEh|ryP MkXFV2FPT0WU
HCC2157 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIOyPJdKSzVyPUCuPFQ6PTFizszN M4[yVHNCVkeHUh?=
BT-474 NFvXXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfETWM2OD1yLki4PFU1KM7:TR?= NWjOXIVyW0GQR1XS
NCI-H748 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwOUGyJO69VQ>? NILhfIRUSU6JRWK=
EW-24 MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDLTWM2OD1yLkmyNFAzKM7:TR?= NGXnV4tUSU6JRWK=
D-263MG M1vHVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHnU4NwUUN3ME2wMlk1PTF{IN88US=> M2HJb3NCVkeHUh?=
OMC-1 M3zXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO0NWdKSzVyPUCuPVY{PzNizszN MV;TRW5ITVJ?
NCI-H2196 Mkf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3P3XGlEPTB;MD65O|c4PyEQvF2= M4HXW3NCVkeHUh?=
HAL-01 NV;sU4VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwOUm4O|Ih|ryP M2\Me3NCVkeHUh?=
NCI-H2107 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTFwMEG4OVQh|ryP M1POTHNCVkeHUh?=
LB996-RCC M1XzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\IZWlEPTB;MT6wPFA2OSEQvF2= M3nRR3NCVkeHUh?=
NCI-H1395 NVr1fJE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13iXGlEPTB;MT6xNFY4KM7:TR?= NUXQNVFSW0GQR1XS
CHP-126 M{TlfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwMU[xPVkh|ryP MYPTRW5ITVJ?
NB69 MlrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rlWmlEPTB;MT6yOlE1QCEQvF2= MV;TRW5ITVJ?
CAS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFwM{SyN|Eh|ryP NVLT[VFTW0GQR1XS
JVM-3 NVrQXoF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvMeY1KSzVyPUGuOFc5PTVizszN NWXNc4R2W0GQR1XS
DMS-153 NFPTclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PTeGlEPTB;MT61O|Y4PCEQvF2= M1i0TXNCVkeHUh?=
SK-MEL-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;Nb2lEPTB;MT63NVc5QSEQvF2= NGX2T|NUSU6JRWK=
NCI-H1155 M4DoTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPDTWM2OD1zLkezOlc3KM7:TR?= M{n5PXNCVkeHUh?=
NCI-H1092 NVXyZ3NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLrRpRlUUN3ME2xMlc3OTh{IN88US=> M37Re3NCVkeHUh?=
LU-165 NGD1O4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfKTWM2OD1zLki2OFc3KM7:TR?= NEXxdlJUSU6JRWK=
HL-60 NFnQNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17L[mlEPTB;MT65PVkxQCEQvF2= NXK4WGtVW0GQR1XS
REH MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJwMEC1PFIh|ryP Mn;sV2FPT0WU
JVM-2 MnLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CyV2lEPTB;Mj6wOlE{PSEQvF2= MXfTRW5ITVJ?
MN-60 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJwMUezNFgh|ryP MVnTRW5ITVJ?
SCC-15 M4PJ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJwMkCyO{DPxE1? MWHTRW5ITVJ?
SNU-C1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXVdpRKSzVyPUKuNlE{PDNizszN M3HRNHNCVkeHUh?=
SK-MEL-1 NXvPXVZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfze4NKSzVyPUKuN|IxPDdizszN M{mwVXNCVkeHUh?=
TGW M1rVemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnqdoVPUUN3ME2yMlM2ODJ5IN88US=> NHrnTGJUSU6JRWK=
CA46 M13kb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;uNmlEPTB;Mj63OVk3PyEQvF2= Mk\FV2FPT0WU
NCI-H23 NXfY[YNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3leHRKSzVyPUKuPFA4QTFizszN NIrVU2tUSU6JRWK=
MMAC-SF NFvGTVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJwOE[2Nlgh|ryP NFnqTWNUSU6JRWK=
NCI-H2171 M3KxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTNwMEO0OFgh|ryP M1L2NHNCVkeHUh?=
A704 NWHNXVNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXmfFdKSzVyPUOuNVQyQTRizszN NHfQU41USU6JRWK=
DB NXHMXpU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrQZ2UzUUN3ME2zMlI2PTd4IN88US=> Moi4V2FPT0WU
NCI-H719 NF7oSoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTNwM{CzPFQh|ryP NYfWbYJ1W0GQR1XS
MC-CAR NWKzUXhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjvOXZsUUN3ME2zMlU1QDF5IN88US=> NHrRXXVUSU6JRWK=
SIMA MmTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PnW2lEPTB;Mz61PFQyPiEQvF2= MnPzV2FPT0WU
SW872 NIHnUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTNwN{ixNFEh|ryP MYTTRW5ITVJ?
HCC1187 M1nlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3QTWM2OD1|Lke4N|E2KM7:TR?= MoXLV2FPT0WU
EW-13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NViz[G1LUUN3ME2zMlg{PDF5IN88US=> NVnzWG5zW0GQR1XS
NCI-SNU-1 M13iT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrzTWM2OD12LkKxPVk6KM7:TR?= M1vJdHNCVkeHUh?=
NCI-H226 NIDWPZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfDbHBKSzVyPUSuN|M3ODZizszN NXjaPWp1W0GQR1XS
RPMI-8866 NWrrZYhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLBb3pKSzVyPUSuN|YxOjlizszN MoW5V2FPT0WU
OCI-AML2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\YSmZSUUN3ME20MlU2OjNizszN NIXpWHdUSU6JRWK=
LU-65 MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHvTWM2OD12LkmzNFM{KM7:TR?= MlLpV2FPT0WU
SK-N-DZ MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTVwNkO0OlUh|ryP MULTRW5ITVJ?
NB14 M172N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmxVnVIUUN3ME21Mlk4OTN3IN88US=> NV\6WYE1W0GQR1XS
COLO-829 NHnxbotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[wTWM2OD14LkOzN|U6KM7:TR?= M3;UU3NCVkeHUh?=
MHH-CALL-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3voWmlEPTB;Nj61NVUxQCEQvF2= NUf5PXhDW0GQR1XS
NCI-H1770 M3v3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTZwNk[5NFQh|ryP MXHTRW5ITVJ?
ECC4 MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;Ub|BKSzVyPU[uPFIyPzlizszN NXPUUJNxW0GQR1XS
A498 NFnMd2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInad2tKSzVyPU[uPFcyQTJizszN MmjmV2FPT0WU
DMS-79 M3iyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTdwMES1NVIh|ryP NHO0UVZUSU6JRWK=
P30-OHK NIfjb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HXT2lEPTB;Nz6yNVkxPiEQvF2= MkPHV2FPT0WU
D-502MG Mn7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzIT4ZKSzVyPUeuPVg{PiEQvF2= MkTyV2FPT0WU
RCC10RGB NYnJd5NGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XnVGlEPTB;OD6wOlI5KM7:TR?= M{nIS3NCVkeHUh?=
U-698-M NE\q[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXYTWM2OD16LkK5NlI3KM7:TR?= NGXKTmVUSU6JRWK=
BB49-HNC M{HiUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXzeWprUUN3ME25MlQzOjZ3IN88US=> NU\QbmJlW0GQR1XS
ES1 NYD6e3B3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTlwNki5OVYh|ryP MX7TRW5ITVJ?
MFM-223 NWTBW4EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnrPFVKSzVyPUGwMlk6OjdizszN NX;GT45lW0GQR1XS
C2BBe1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFzLkO1NlMh|ryP M4rrOHNCVkeHUh?=
EB2 Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvmbFVKSzVyPUGyMlY5QDFizszN MYrTRW5ITVJ?
C8166 MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGr6OZNKSzVyPUGzMlg{ODNizszN M1v3ZnNCVkeHUh?=
ES3 M1\qVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknuTWM2OD1zMz65PVc4KM7:TR?= MofWV2FPT0WU
NCI-H1650 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnYRlZwUUN3ME2xOk4{PzZ3IN88US=> NE\3XG5USU6JRWK=
Mo-T Mo\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnETWM2OD1zNz60NFI6KM7:TR?= NYXVWXlxW0GQR1XS
NB7 MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DGZmlEPTB;MUeuO|Q3PyEQvF2= MVPTRW5ITVJ?
ES7 NXe5[HRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTF7LkW1NFch|ryP MmrhV2FPT0WU
ES5 M3vISWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrLOWdSUUN3ME2yNU44PjdzIN88US=> M1;PfnNCVkeHUh?=
MSTO-211H NWrqO2FOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDEelZ{UUN3ME2yNU45QDV6IN88US=> MXzTRW5ITVJ?
U-87-MG MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJ3LkG5OlYh|ryP MkG1V2FPT0WU
THP-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknvTWM2OD1{OT63NlAyKM7:TR?= MnnJV2FPT0WU
NB10 M{\POGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjuNpJKSzVyPUOwMlI3QTRizszN MXvTRW5ITVJ?
NH-12 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn2[HJlUUN3ME2zN{4zODF5IN88US=> MXfTRW5ITVJ?
COLO-824 NI\jc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTN2LkGwNFYh|ryP MoHIV2FPT0WU
SKM-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFO0bpRKSzVyPUO3Mlg1OjJizszN MXvTRW5ITVJ?
NCI-H1838 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTN6LkO3PVch|ryP NGTofXRUSU6JRWK=
RL MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2mySmlEPTB;M{muNlQ4PyEQvF2= NWXlUodqW0GQR1XS
COLO-800 M1jGdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnReIZwUUN3ME20NE4xPzd|IN88US=> M1TYeXNCVkeHUh?=
KG-1 NHG2NnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fkfmlEPTB;NECuPFk2PSEQvF2= NHj2dIJUSU6JRWK=
TUR MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrtRodKSzVyPUSxMlY{QTlizszN NHTuXXVUSU6JRWK=
LNCaP-Clone-FGC Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEWzZphKSzVyPUSxMlkxOTdizszN M{m2XnNCVkeHUh?=
NCI-H322M MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HDcWlEPTB;NEKuOVk5PCEQvF2= NV3M[FFYW0GQR1XS
LNCaP  NUfwb4JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzUUmJKSzVyPUmxMlMhdk1? NFnGV|YzPTVyNUG3OC=>
C4-2 NIDXPYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRThibl2= M3PZXlI2PTB3MUe0
JURKAT MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LhcFI1KGh? MUTJR|UxRTRzNj62OkBvVQ>? M1P3WVI1PTF7OUm1
MOLT-4 NGjWU|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHToVpkzPCCq M4[4NmlEPTB;Mki1N{42KG6P NWTEWVZrOjR3MUm5PVU>
REH MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknwNlQhcA>? MWfJR|UxRTJ6Nz62PEBvVQ>? MXeyOFUyQTl7NR?=
NALM-6 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVKyOEBp NGTt[GZKSzVyPUO0N|MxKG6P NGK4OFUzPDVzOUm5OS=>
RS 4;11 Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXkUIdqOjRiaB?= M2HaSmlEPTB;NUG5MlA2KG6P MmnMNlQ2OTl7OUW=
697 NEXJeGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\vNlQhcA>? Mo\PTWM2OD1{MUC3MlEhdk1? MmnBNlQ2OTl7OUW=
SIL-ALL MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGyNlQhcA>? MoTYTWM2OD1zOUmuO|chdk1? NYfLRWV4OjR3MUm5PVU>
CEM NUO5ZVZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3memZbOjRiaB?= Mm\NTWM2OD13Mj6xPEBvVQ>? MlHyNlQ2OTl7OUW=
P12 MlfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLCbGdqOjRiaB?= M4nl[WlEPTB;M{muNlchdk1? MWmyOFUyQTl7NR?=
NALM-16 MlzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LhNlI1KGh? M1fnPWlEPTB;OU[uNlghdk1? NH;kVlkzPDVzOUm5OS=>
JURKAT NYq2TZp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjjT3I1QCCq Mn;1TWM2OD1zND64OEBvVQ>? M1;ufVI1PTF7OUm1
MOLT-4 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWS0PEBp NXnWcpJFUUN3ME2yOk43KG6P NGLU[XkzPDVzOUm5OS=>
REH NX7zZo9IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXuRWw1QCCq M1PLOWlEPTB;NESuO|Ehdk1? NFfFOI4zPDVzOUm5OS=>
NALM-6 NFT6clBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrpeGk1QCCq NES2W5hKSzVyPUKzMlI3KG6P NIL0WIYzPDVzOUm5OS=>
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... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

文献中の引用 (52)

Frequently Asked Questions

  • Question 1
    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

    Answer: For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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