BI 2536 化学構造
分子量: 521.66

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Quality Control & MSDS

製品説明

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    PLK製品生物活性の比較
  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 M2noSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjOfWNKSzVyPUCuNFA4PzZizszN M{[w[nNCVkeHUh?=
ACN M3HHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDNTWM2OD1yLkCwPFQ{KM7:TR?= NXrIVnJjW0GQR1XS
TE-8 NXuwc4ZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn3NYZsUUN3ME2wMlAxQTRzIN88US=> MWrTRW5ITVJ?
LC-2-ad NGXtcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nnVGlEPTB;MD6wNVA6OyEQvF2= MYHTRW5ITVJ?
ALL-PO MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEGzJO69VQ>? NVLReHNvW0GQR1XS
EW-16 MmLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\z[WlEPTB;MD6wNVM{PiEQvF2= M3XVU3NCVkeHUh?=
KM12 M1j1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEGzOFgh|ryP Mn;nV2FPT0WU
GI-1 NXXkb4JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H4RWlEPTB;MD6wNVM5OyEQvF2= NIfGbWtUSU6JRWK=
LS-411N Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m0SGlEPTB;MD6wNVQxPyEQvF2= M3HxcnNCVkeHUh?=
ES8 M{XMbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEG0PVQh|ryP MWfTRW5ITVJ?
SNU-C2B MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEG1NlYh|ryP NXKyN4VmW0GQR1XS
CESS Mm\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTOTWM2OD1yLkCxOlAzKM7:TR?= NFfVRVBUSU6JRWK=
697 NH7vVYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDnOms3UUN3ME2wMlAyPjZ6IN88US=> M1WweHNCVkeHUh?=
NCI-H1963 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPkRZpKSzVyPUCuNFE3PzNizszN MV\TRW5ITVJ?
IA-LM MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEG2PFgh|ryP MWDTRW5ITVJ?
SW954 M1XINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Hx[mlEPTB;MD6wNVcxPSEQvF2= NGeySmRUSU6JRWK=
RL95-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHodGhpUUN3ME2wMlAyPzN6IN88US=> M{XyR3NCVkeHUh?=
LXF-289 MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\WUWlEPTB;MD6wNVc4KM7:TR?= NXjldJVNW0GQR1XS
OCUB-M MoG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEG4NlYh|ryP NWHUOIp2W0GQR1XS
RKO MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfXeFFKSzVyPUCuNFE6QDdizszN M{nzb3NCVkeHUh?=
LOUCY MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEKwOUDPxE1? M1;tVnNCVkeHUh?=
NOS-1 NETLNXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfvTWM2OD1yLkCyNFk{KM7:TR?= M3j5WXNCVkeHUh?=
A4-Fuk MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTLbYhzUUN3ME2wMlAzOjF6IN88US=> NEPk[ldUSU6JRWK=
A388 Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEKyNlch|ryP NWXlT3VwW0GQR1XS
TE-9 NIXZ[FFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHwTWM2OD1yLkCyNlYyKM7:TR?= M2jpcnNCVkeHUh?=
KURAMOCHI Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEKyPFUh|ryP MXHTRW5ITVJ?
KALS-1 MoHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDkWWlkUUN3ME2wMlAzOzN6IN88US=> NX;xZ5o5W0GQR1XS
HOP-62 Ml;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn6b4l7UUN3ME2wMlAzPDJizszN NXPCUo0yW0GQR1XS
RPMI-8402 NYDEN3Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXWUmdZUUN3ME2wMlAzPTB6IN88US=> NETWXJNUSU6JRWK=
TE-1 M3;DNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf2RmhKSzVyPUCuNFI2OTJizszN NHWwZm9USU6JRWK=
CCRF-CEM M1O2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrER5JKSzVyPUCuNFI2PDNizszN M2LhcnNCVkeHUh?=
HUTU-80 NXzVfm1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEK2NlQh|ryP MYfTRW5ITVJ?
NCI-H1648 M3ezS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEK2OFch|ryP NES2fZJUSU6JRWK=
HCE-4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTndIlOUUN3ME2wMlAzPjh{IN88US=> NX74TYpEW0GQR1XS
ETK-1 NXnJVYdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnLOlRKSzVyPUCuNFI4OzZizszN NXfSVoR2W0GQR1XS
TE-15 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz1TWM2OD1yLkCyO|M5KM7:TR?= M2DlNXNCVkeHUh?=
BE-13 M{DEcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPETWM2OD1yLkCyO|Qh|ryP NEC4SoZUSU6JRWK=
KE-37 Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DmPGlEPTB;MD6wNlc1OSEQvF2= NUX2V3hvW0GQR1XS
NCI-H1355 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fvZWlEPTB;MD6wNlc5OyEQvF2= NEK0ZWZUSU6JRWK=
TE-11 NIXyUnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\GXmhKSzVyPUCuNFI5ODlizszN NEDDXWVUSU6JRWK=
BL-70 NYjLUYM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL5TWM2OD1yLkCyPFU4KM7:TR?= NVzaUXNKW0GQR1XS
ES6 MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M133eWlEPTB;MD6wNlg5OSEQvF2= NF;nXIhUSU6JRWK=
GT3TKB M17ve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TCd2lEPTB;MD6wNlk2OyEQvF2= NHHw[pVUSU6JRWK=
LB647-SCLC MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX3SXh{UUN3ME2wMlA{OTl3IN88US=> NGPR[49USU6JRWK=
NB13 NVzZTYtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\qXGFKSzVyPUCuNFM{OTZizszN NWrTTGNyW0GQR1XS
ST486 M1:1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMEOzN|ch|ryP MX\TRW5ITVJ?
NCI-H82 NHW3PHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzzR2cxUUN3ME2wMlA{OzR|IN88US=> M2G3WXNCVkeHUh?=
NTERA-S-cl-D1 NUS5WFFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\Me3RYUUN3ME2wMlA{Ozl7IN88US=> MXjTRW5ITVJ?
ES4 NFHw[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DVS2lEPTB;MD6wN|Q3OyEQvF2= MVjTRW5ITVJ?
SK-NEP-1 NYf4V2hDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\QO2lEPTB;MD6wN|Q6QSEQvF2= MVrTRW5ITVJ?
Becker NVz1T4p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rIT2lEPTB;MD6wN|U2PSEQvF2= M135b3NCVkeHUh?=
A101D NU\pPXZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S4OmlEPTB;MD6wN|c1QCEQvF2= MYTTRW5ITVJ?
SK-UT-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELjR5pKSzVyPUCuNFM4PzRizszN MX;TRW5ITVJ?
SW982 M2rKOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\PVHozUUN3ME2wMlA{PzlizszN M4OySHNCVkeHUh?=
TE-10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\yRWlEPTB;MD6wOFA1PiEQvF2= NXu5OIZlW0GQR1XS
OVCAR-4 NV;NTlExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMESwOVkh|ryP M2nsUXNCVkeHUh?=
KP-N-YS NIjib3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS2TWM2OD1yLkC0NFg2KM7:TR?= NVfZNpY2W0GQR1XS
BL-41 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMESxNlUh|ryP MV;TRW5ITVJ?
MZ1-PC NHPsSlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH3TWM2OD1yLkC0NVI4KM7:TR?= NYnhVpVPW0GQR1XS
PF-382 NUjKenE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGC0R4xKSzVyPUCuNFQyQThizszN MWDTRW5ITVJ?
MOLT-13 M4jH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\FdmlEPTB;MD6wOFI{QCEQvF2= NHjp[GNUSU6JRWK=
HCC1599 Mn2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvRb3hZUUN3ME2wMlA1OjV6IN88US=> M4nxZnNCVkeHUh?=
IST-MEL1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S0TWlEPTB;MD6wOFQ1OiEQvF2= M2TJcnNCVkeHUh?=
LU-139 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMES0OFIh|ryP M4rZXHNCVkeHUh?=
MS-1 NGnCRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n2OmlEPTB;MD6wOFcxOSEQvF2= M1[1NHNCVkeHUh?=
MFH-ino NVnwXHNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PEVWlEPTB;MD6wOVAxOyEQvF2= MX;TRW5ITVJ?
IMR-5 NVvHdmc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS0d2FlUUN3ME2wMlA2ODJzIN88US=> NUTVUVNmW0GQR1XS
TE-5 NHjGTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nXZmlEPTB;MD6wOVA3OyEQvF2= NX[5O41uW0GQR1XS
DJM-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK0d2M6UUN3ME2wMlA2OTR{IN88US=> MUHTRW5ITVJ?
NB17 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TNdGlEPTB;MD6wOVIxPyEQvF2= NHvWTmVUSU6JRWK=
KARPAS-45 NF7zNXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPoclRKSzVyPUCuNFU{PThizszN M{nRcnNCVkeHUh?=
TGBC1TKB NHLTS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEW0NFUh|ryP NUO4VIc2W0GQR1XS
ML-2 NGrTemRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LwZWlEPTB;MD6wOVQyPCEQvF2= MVrTRW5ITVJ?
no-10 NUXjc2oxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEW0O|Qh|ryP NGLtWVlUSU6JRWK=
CTV-1 Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S3[mlEPTB;MD6wOVUxOiEQvF2= MnnZV2FPT0WU
SJSA-1 Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELsZY9KSzVyPUCuNFU2OiEQvF2= NV;odWRFW0GQR1XS
HC-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlyxTWM2OD1yLkC1OVk4KM7:TR?= NWLDcoNWW0GQR1XS
TE-12 M{fobWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D6c2lEPTB;MD6wOVYyOyEQvF2= MYnTRW5ITVJ?
KY821 NGi4[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvGRW9KSzVyPUCuNFU3OzJizszN MX7TRW5ITVJ?
TALL-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEW3NFgh|ryP NYG3V4JYW0GQR1XS
DEL MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7HV2pRUUN3ME2wMlA2PzB7IN88US=> MX\TRW5ITVJ?
TE-6 M4LPOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHJeoNNUUN3ME2wMlA2PzJ{IN88US=> NY\4fZpLW0GQR1XS
SK-LMS-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33GOWlEPTB;MD6wOVgxPSEQvF2= M3q4TXNCVkeHUh?=
EW-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPOTWM2OD1yLkC1PFM4KM7:TR?= MXfTRW5ITVJ?
8-MG-BA M1nDUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f1VWlEPTB;MD6wOVg2OSEQvF2= M{D1SXNCVkeHUh?=
NALM-6 M1jDNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33Y[GlEPTB;MD6wOVk4OyEQvF2= NHTmOVVUSU6JRWK=
LB771-HNC M1;lc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzMTWM2OD1yLkC1PVc6KM7:TR?= M3X0NXNCVkeHUh?=
HT-144 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojXTWM2OD1yLkC2NVMh|ryP MYfTRW5ITVJ?
KM-H2 NGP0fopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnGTWM2OD1yLkC2NlIyKM7:TR?= M3v3R3NCVkeHUh?=
SF268 M4fzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPL[3pkUUN3ME2wMlA3Ojh4IN88US=> MWTTRW5ITVJ?
RS4-11 M{Tmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7HXHdKSzVyPUCuNFY{ODRizszN MWfTRW5ITVJ?
MHH-PREB-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L3OWlEPTB;MD6wOlMyQSEQvF2= Mn\tV2FPT0WU
ATN-1 Mmn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwME[zOFUh|ryP NWS0[ppsW0GQR1XS
BB30-HNC M2jhUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwME[0N|Yh|ryP MXPTRW5ITVJ?
CPC-N M3y0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLyTWM2OD1yLkC2OVI1KM7:TR?= NYW1[2JNW0GQR1XS
NB1 MmfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHCeGNOUUN3ME2wMlA3PjF|IN88US=> MUXTRW5ITVJ?
KS-1 NWfOPZk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwME[3OFgh|ryP MXnTRW5ITVJ?
RXF393 NUn5e4NVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwME[3OlQh|ryP M2XBc3NCVkeHUh?=
IST-SL2 NGPtR3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj2TWM2OD1yLkC3NFA1KM7:TR?= NIfMeYhUSU6JRWK=
GI-ME-N MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEeyPFYh|ryP NXjuUWU2W0GQR1XS
VA-ES-BJ MmjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfrSmN{UUN3ME2wMlA4PDd3IN88US=> MmPzV2FPT0WU
NCI-H1581 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXpUJlEUUN3ME2wMlA4PDd6IN88US=> M2XtdXNCVkeHUh?=
U-266 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPYUW1KSzVyPUCuNFc1QTdizszN NX7MPGM2W0GQR1XS
DMS-114 MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEe1Nlgh|ryP MlS4V2FPT0WU
NCI-H187 MmDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;MUWVZUUN3ME2wMlA4PzJ4IN88US=> MYHTRW5ITVJ?
SW962 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPtTWVKSzVyPUCuNFc5OzlizszN NWHrTlFxW0GQR1XS
MONO-MAC-6 M3[1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrVU4pFUUN3ME2wMlA4QTh4IN88US=> MYXTRW5ITVJ?
MOLT-16 MmjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzyTWM2OD1yLkC4NVIyKM7:TR?= MYfTRW5ITVJ?
KNS-42 NWKxZWNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEixOlEh|ryP M4LtXnNCVkeHUh?=
CMK NHnZe5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrYTWM2OD1yLkC4NlI2KM7:TR?= M1HNe3NCVkeHUh?=
Ramos-2G6-4C10 NGiwT41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrmUWZKSzVyPUCuNFgzOjVizszN MVzTRW5ITVJ?
Daudi M1\XSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEiyOVYh|ryP NGLkV|NUSU6JRWK=
NCI-H510A M2Wx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEizN|Yh|ryP Mn7MV2FPT0WU
LB831-BLC NIXxOlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfqTXJKSzVyPUCuNFg2PjFizszN Mm\5V2FPT0WU
HEL MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[yZnNKSzVyPUCuNFg3PjhizszN M2fncnNCVkeHUh?=
LU-134-A MoDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3QXYFwUUN3ME2wMlA5PzB6IN88US=> NYDDUphSW0GQR1XS
NCI-H1694 NVrjTFZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEi3OFQh|ryP MV;TRW5ITVJ?
KGN NWP3XIZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInDPVFKSzVyPUCuNFg4PTlizszN NXjlNoo2W0GQR1XS
A253 M13rZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEi4NlIh|ryP NHSzOoFUSU6JRWK=
DG-75 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nCcmlEPTB;MD6wPFkzOiEQvF2= MWLTRW5ITVJ?
MOLT-4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;jd|dKSzVyPUCuNFg6QDNizszN M3LyWXNCVkeHUh?=
NCI-SNU-5 NH;odlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEmyOVgh|ryP NV;ydZV3W0GQR1XS
ONS-76 NXjyUGFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfKTWM2OD1yLkC5Nlc3KM7:TR?= NHvJcJBUSU6JRWK=
NCI-H446 M2TLN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf1TWM2OD1yLkC5OFYzKM7:TR?= Ml7aV2FPT0WU
COR-L279 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMEm1OVYh|ryP MYPTRW5ITVJ?
Calu-6 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2KyUmlEPTB;MD6wPVU6QCEQvF2= MoXWV2FPT0WU
BC-3 NULMZ3M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXo[|VjUUN3ME2wMlA6PjZ{IN88US=> MliyV2FPT0WU
NCI-H2126 NWTmSYl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn6SJNCUUN3ME2wMlA6PzlzIN88US=> MWrTRW5ITVJ?
NCI-H1882 NIPsUFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPPZYFIUUN3ME2wMlA6QDB7IN88US=> NUTUOHRlW0GQR1XS
BB65-RCC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHFWHJKSzVyPUCuNVAzQTRizszN NWrCNJp[W0GQR1XS
DU-4475 M2mxbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fSVGlEPTB;MD6xNFQxPyEQvF2= MX3TRW5ITVJ?
NCI-H526 NWj2fmZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rtbGlEPTB;MD6xNFQ1KM7:TR?= MUnTRW5ITVJ?
NEC8 NGDFZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXHOGJKSzVyPUCuNVA2OjVizszN MW\TRW5ITVJ?
NCI-H1304 MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnpTWM2OD1yLkGwOVk1KM7:TR?= MkW0V2FPT0WU
L-540 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fFR2lEPTB;MD6xNFcxQCEQvF2= MoHXV2FPT0WU
NCI-SNU-16 Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDYTWM2OD1yLkGwO|QzKM7:TR?= NX\1U5NxW0GQR1XS
HD-MY-Z NYTmUYozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3J[FBKSzVyPUCuNVA5PTZizszN MnroV2FPT0WU
K-562 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXmSlhKSzVyPUCuNVA5PThizszN MmLxV2FPT0WU
JAR MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOzOmRNUUN3ME2wMlExQTJ3IN88US=> NETSToFUSU6JRWK=
MZ2-MEL NUXmZnM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T5O2lEPTB;MD6xNVA2KM7:TR?= NFS1T25USU6JRWK=
L-363 MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nuWGlEPTB;MD6xNVA4QSEQvF2= NWfCWZpFW0GQR1XS
BV-173 NWTPTXlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnqZlZKSzVyPUCuNVEzPDNizszN MkDNV2FPT0WU
NCI-H524 M1zPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\MTmlEPTB;MD6xNVI4PCEQvF2= M{fD[nNCVkeHUh?=
EoL-1-cell MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLRbllDUUN3ME2wMlEyPjd{IN88US=> MV3TRW5ITVJ?
K052 NI\Ee|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDzTWM2OD1yLkGxO|EzKM7:TR?= MkXkV2FPT0WU
TK10 NXryNHVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jkcmlEPTB;MD6xNVczQCEQvF2= MkjKV2FPT0WU
KU812 MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fpXmlEPTB;MD6xNlA1PCEQvF2= M{e3OXNCVkeHUh?=
RPMI-8226 M{LS[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jFS2lEPTB;MD6xNlA2OiEQvF2= M1zHW3NCVkeHUh?=
MZ7-mel MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nMU2lEPTB;MD6xNlI{PyEQvF2= MYTTRW5ITVJ?
SK-PN-DW MoTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe2VldkUUN3ME2wMlEzOjh5IN88US=> MVvTRW5ITVJ?
SR Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILxfGRKSzVyPUCuNVI1PDFizszN NF7HfohUSU6JRWK=
RPMI-6666 M1y3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\RTWM2OD1yLkGyO|Q{KM7:TR?= NE\yZlVUSU6JRWK=
no-11 M2fmcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\ITWM2OD1yLkGyPFY6KM7:TR?= M3vwNnNCVkeHUh?=
EW-3 NFfVXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NED4OnFKSzVyPUCuNVI5QTNizszN MXvTRW5ITVJ?
LAMA-84 MnPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH2[IRlUUN3ME2wMlE{OTh5IN88US=> NIrROlNUSU6JRWK=
HT MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHaO2tSUUN3ME2wMlE{PTd2IN88US=> MVPTRW5ITVJ?
KP-N-RT-BM-1 MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33oWWlEPTB;MD6xN|YyOiEQvF2= NEPEcoRUSU6JRWK=
NCI-H747 NXXSNYM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:1bWJKSzVyPUCuNVM4KM7:TR?= MmjjV2FPT0WU
NCCIT MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMUO5N|kh|ryP M1Tqe3NCVkeHUh?=
MLMA NXLFWHRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3njdWlEPTB;MD6xOFE3PyEQvF2= MX;TRW5ITVJ?
LP-1 NHHwTHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXYcXVKSzVyPUCuNVQzPCEQvF2= M{SzNXNCVkeHUh?=
CAL-148 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHn[G9KSzVyPUCuNVQ1QDNizszN Ml\tV2FPT0WU
GB-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjqTlBKSzVyPUCuNVQ2OjZizszN MVvTRW5ITVJ?
COR-L88 M{[1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nhVGlEPTB;MD6xOFgxOiEQvF2= NX;wVVdnW0GQR1XS
NKM-1 M4SyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrrWFRKSzVyPUCuNVQ6ODZizszN MWjTRW5ITVJ?
NB5 NWfKe5A2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMUW0OlIh|ryP Mk\FV2FPT0WU
SH-4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\MSodKSzVyPUCuNVU1PjZizszN MoixV2FPT0WU
EM-2 NUTOOWQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP3TWM2OD1yLkG1OFY4KM7:TR?= M4XJcnNCVkeHUh?=
TGBC24TKB MnSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\WTGlEPTB;MD6xOVY2QSEQvF2= NWXveWVIW0GQR1XS
SCLC-21H MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIO1Om9KSzVyPUCuNVU4ODJizszN NFvyNJhUSU6JRWK=
COLO-684 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXtd4ZKSzVyPUCuNVU4OjFizszN NX76PVZxW0GQR1XS
KINGS-1 M3G3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LzW2lEPTB;MD6xOVkyKM7:TR?= M4rrc3NCVkeHUh?=
LS-123 M4rtcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHQTWM2OD1yLkG1PVE4KM7:TR?= MV7TRW5ITVJ?
MC116 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jUV2lEPTB;MD6xOlE2QCEQvF2= NIrqZZRUSU6JRWK=
SU-DHL-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkW0TWM2OD1yLkG2NlA3KM7:TR?= M4K4R3NCVkeHUh?=
NCI-H64 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMU[zOFch|ryP NWLITXVLW0GQR1XS
HCE-T MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXCTWM2OD1yLkG2OVA1KM7:TR?= M3T2dXNCVkeHUh?=
LOXIMVI MlTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M164eGlEPTB;MD6xOlk1QSEQvF2= NH;LOYZUSU6JRWK=
ARH-77 M4S5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HuTGlEPTB;MD6xO|M4QSEQvF2= NEnESYhUSU6JRWK=
DOHH-2 NEfCcG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LEbmlEPTB;MD6xO|Y4OiEQvF2= MXvTRW5ITVJ?
COLO-320-HSR NHXNeYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMUixOVQh|ryP MoXkV2FPT0WU
NB6 M2C5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3rRYZSUUN3ME2wMlE5PTZ4IN88US=> NH7tWnhUSU6JRWK=
L-428 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq4TWM2OD1yLkG4PFE{KM7:TR?= NFfie29USU6JRWK=
SNB75 MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIf3botKSzVyPUCuNVg5OjRizszN NGL5WYdUSU6JRWK=
NCI-H2141 Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMUmwNVEh|ryP NX;xPHZVW0GQR1XS
KARPAS-299 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMUmyOFEh|ryP MUDTRW5ITVJ?
LC4-1 M{LweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMUm1NFIh|ryP NGLuRWxUSU6JRWK=
UACC-257 M4O1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm4V2pKSzVyPUCuNVk6PDdizszN NV3INnpjW0GQR1XS
EVSA-T Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnrTWM2OD1yLkKwN|EzKM7:TR?= MnzjV2FPT0WU
JiyoyeP-2003 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInFUmhKSzVyPUCuNlA1PzdizszN MnvrV2FPT0WU
NCI-H720 MkDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjVRmlKSzVyPUCuNlA2OjVizszN NEn4dmlUSU6JRWK=
GAK M1\ZPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7UTplUUUN3ME2wMlIyOTh7IN88US=> MkXUV2FPT0WU
HH MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrOTWM2OD1yLkKxOFA2KM7:TR?= MnfLV2FPT0WU
NCI-H1436 M3KxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjOZVY1UUN3ME2wMlIyPDZ2IN88US=> NX60Z21CW0GQR1XS
GR-ST MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DDU2lEPTB;MD6yNVQ5QCEQvF2= NYrSfHJoW0GQR1XS
BC-1 NFz2c2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnDTWM2OD1yLkKyOlE3KM7:TR?= MXnTRW5ITVJ?
SIG-M5 NGXFZ5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXUTWM2OD1yLkKyO|I4KM7:TR?= NV3KNZY1W0GQR1XS
NCI-H345 NEfhO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TLO2lEPTB;MD6yN|gxPSEQvF2= NFTiWHVUSU6JRWK=
OPM-2 MkK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXSUXJKSzVyPUCuNlM5QDJizszN NHPvTlhUSU6JRWK=
LB1047-RCC M1ThN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjSNIhKSzVyPUCuNlQ1OSEQvF2= M4LYUXNCVkeHUh?=
CTB-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPXRoVCUUN3ME2wMlI1PDl|IN88US=> Mn\5V2FPT0WU
A3-KAW MlfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjnR2FKSzVyPUCuNlU{PDFizszN M4KwSHNCVkeHUh?=
SF126 NXTaO4U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMkWzPFMh|ryP NWjSZ2p6W0GQR1XS
KARPAS-422 NIX4N4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWP1TnM6UUN3ME2wMlI2PDN3IN88US=> MUHTRW5ITVJ?
MEG-01 NXjsOWFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzUTWM2OD1yLkK1Olc{KM7:TR?= M1\xcnNCVkeHUh?=
NCI-H209 MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XGZ2lEPTB;MD6yOlM4PCEQvF2= Mm\UV2FPT0WU
SBC-1 NH\LbGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMk[1JO69VQ>? M4nnU3NCVkeHUh?=
K5 M{jwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe4Z5VUUUN3ME2wMlI3QTh2IN88US=> NUjZb2Z2W0GQR1XS
QIMR-WIL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jiZmlEPTB;MD6yO|E2PSEQvF2= NEWzRm5USU6JRWK=
NMC-G1 M4\U[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMkiyNVch|ryP NIHUTJFUSU6JRWK=
IST-MES1 MoLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3lTWM2OD1yLkK5NlM5KM7:TR?= MV3TRW5ITVJ?
SW684 NYTrSZBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwM{CwOFch|ryP MlPtV2FPT0WU
MV-4-11 NGftSZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHReotKSzVyPUCuN|A4QDhizszN NXLs[VdPW0GQR1XS
LAN-6 NGLWUHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrB[4hGUUN3ME2wMlMyPTd{IN88US=> Mn\qV2FPT0WU
RH-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTwTWM2OD1yLkOxPFcyKM7:TR?= MkXTV2FPT0WU
CP66-MEL MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XLSWlEPTB;MD6zNVg4QCEQvF2= MlziV2FPT0WU
EC-GI-10 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfQOYlKSzVyPUCuN|I6QDdizszN MnThV2FPT0WU
GDM-1 NWjOOZB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUeyZVJRUUN3ME2wMlM{ODV7IN88US=> MYLTRW5ITVJ?
IST-SL1 M2jtNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\kemlEPTB;MD6zOFkyPCEQvF2= M4TQXHNCVkeHUh?=
KMOE-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[4fWoxUUN3ME2wMlM2OTd3IN88US=> MXrTRW5ITVJ?
OS-RC-2 NGfPTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;FVZVKSzVyPUCuN|U2PDRizszN NVK5fm9ZW0GQR1XS
HDLM-2 M3fzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPIV29KSzVyPUCuN|c5OTRizszN MYTTRW5ITVJ?
DSH1 NX7sd5p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfyN2JKSzVyPUCuN|g3OzFizszN MX7TRW5ITVJ?
LS-1034 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwM{i5OVQh|ryP M2e2cHNCVkeHUh?=
LB373-MEL-D NEfYco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTjOVZqUUN3ME2wMlM6OTl5IN88US=> MkHlV2FPT0WU
GOTO M3zLNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwNEKxNVgh|ryP NH;hR|ZUSU6JRWK=
MRK-nu-1 NEXTOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;tOWlEPTB;MD60NlIxPSEQvF2= NWXXcnRzW0GQR1XS
SK-MM-2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TzTGlEPTB;MD60N|Q1OiEQvF2= NHnWSVlUSU6JRWK=
BOKU M1HjXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnPVnNMUUN3ME2wMlQ{Pzl{IN88US=> MX;TRW5ITVJ?
NOMO-1 NFzs[45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXGVWlKSzVyPUCuOFM5PiEQvF2= MYLTRW5ITVJ?
J-RT3-T3-5 NWLHUW9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDhTWM2OD1yLkS0PFc5KM7:TR?= MVjTRW5ITVJ?
COLO-668 M4fv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnTOIRsUUN3ME2wMlQ2PjZ6IN88US=> M4nBUnNCVkeHUh?=
SF539 MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrPTWM2OD1yLkS4Olg1KM7:TR?= NYTUbFlEW0GQR1XS
LB2518-MEL MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq4TWM2OD1yLkS5O|A{KM7:TR?= NVnjd|U5W0GQR1XS
TE-441-T M{Lvd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nQ[2lEPTB;MD61NFEzKM7:TR?= NUTxNoM{W0GQR1XS
MDA-MB-134-VI MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX76dZFbUUN3ME2wMlUxQTJzIN88US=> NUXQOphxW0GQR1XS
SCC-3 NF3SO2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWroXopMUUN3ME2wMlUyQDd|IN88US=> NILpcmpUSU6JRWK=
KLE NITuXm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwNUKxO|Eh|ryP M1;iRXNCVkeHUh?=
LB2241-RCC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPsRnBKSzVyPUCuOVI2OjVizszN M33GeHNCVkeHUh?=
NCI-H1417 M2H2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorDTWM2OD1yLkWzOFM2KM7:TR?= MUPTRW5ITVJ?
NCI-H2081 M4TqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XsPGlEPTB;MD61PFYyOSEQvF2= MXfTRW5ITVJ?
NCI-H1522 M1LRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HoXWlEPTB;MD61PVM5OyEQvF2= NX;zdo9KW0GQR1XS
NCI-H889 MkP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHuTWM2OD1yLkW5PFQ1KM7:TR?= MoTpV2FPT0WU
CGTH-W-1 M4jHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LyNmlEPTB;MD62NFc2PSEQvF2= MknVV2FPT0WU
EB-3 NEX0UmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnrZldtUUN3ME2wMlYyOTV|IN88US=> M3TIe3NCVkeHUh?=
D-336MG M3XWUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3yW2hMUUN3ME2wMlYyPzlzIN88US=> NEjrVGdUSU6JRWK=
LC-1F NFy4S|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXibXRKSzVyPUCuOlI2QTJizszN NIPHVnZUSU6JRWK=
MHH-NB-11 M4f3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\rTWM2OD1yLk[zPFAyKM7:TR?= MYXTRW5ITVJ?
SK-N-FI M37vSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\DTWM2OD1yLk[zPVEh|ryP M{PidHNCVkeHUh?=
NCI-H69 M3HtfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwNkS4O|kh|ryP M3i5eXNCVkeHUh?=
SCH MlfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljWTWM2OD1yLk[2NFI{KM7:TR?= MWnTRW5ITVJ?
LS-513 NE[2fYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX2cHJRUUN3ME2wMlY4OjV7IN88US=> NULwS5JKW0GQR1XS
CP67-MEL MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETpSYdKSzVyPUCuOlc2QTZizszN NWDWNpI2W0GQR1XS
GCIY MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnyd3VCUUN3ME2wMlcxOzZ|IN88US=> NFO1Z5VUSU6JRWK=
SHP-77 MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnaTWM2OD1yLkewO|M1KM7:TR?= MXjTRW5ITVJ?
EHEB M3LNUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;WNWxWUUN3ME2wMlcyQDV2IN88US=> NXPYVYZXW0GQR1XS
D-247MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPzTWM2OD1yLkezNlMzKM7:TR?= M4Lu[XNCVkeHUh?=
Raji Mn;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXLVZFJUUN3ME2wMlc1QTh7IN88US=> NFS1RlFUSU6JRWK=
MPP-89 NXPSZ2psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\XTWM2OD1yLke1PVc5KM7:TR?= NYLVboRvW0GQR1XS
EKVX M13KV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrwTWM2OD1yLke5NFc{KM7:TR?= MUPTRW5ITVJ?
HCC2218 M2\4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PnN2lEPTB;MD63PVE{OSEQvF2= MnnKV2FPT0WU
KNS-81-FD M{XTZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2W0U2lEPTB;MD64NVAyOSEQvF2= MWPTRW5ITVJ?
HCC2157 NHL4WIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHDd21KSzVyPUCuPFQ6PTFizszN NYfMcoNrW0GQR1XS
BT-474 NYnxW4lyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlToTWM2OD1yLki4PFU1KM7:TR?= MojQV2FPT0WU
NCI-H748 M3HyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGi1cllKSzVyPUCuPVEzKM7:TR?= MWHTRW5ITVJ?
EW-24 NGLw[pFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwOUKwNFIh|ryP NELwUHdUSU6JRWK=
D-263MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTqTWM2OD1yLkm0OVEzKM7:TR?= MoC2V2FPT0WU
OMC-1 NGjOPZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PKOGlEPTB;MD65OlM4OyEQvF2= M{XobHNCVkeHUh?=
NCI-H2196 M3myfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGeyVoVKSzVyPUCuPVc4PzdizszN M1;EOHNCVkeHUh?=
HAL-01 M1PKZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwOUm4O|Ih|ryP Mnj5V2FPT0WU
NCI-H2107 MlfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL5fpRzUUN3ME2xMlAyQDV2IN88US=> MoLnV2FPT0WU
LB996-RCC MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFwMEiwOVEh|ryP MVHTRW5ITVJ?
NCI-H1395 NY\Pd2l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTSVVJUUUN3ME2xMlExPjdizszN M2nQSnNCVkeHUh?=
CHP-126 MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXuPXBKSzVyPUGuNVYyQTlizszN M1TqZXNCVkeHUh?=
NB69 NHnFc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHCTWM2OD1zLkK2NVQ5KM7:TR?= MV3TRW5ITVJ?
CAS-1 M3uy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvFTWM2OD1zLkO0NlMyKM7:TR?= NXjBNoR[W0GQR1XS
JVM-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD3TWFoUUN3ME2xMlQ4QDV3IN88US=> NVTXUo03W0GQR1XS
DMS-153 M2nscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq4b4NKSzVyPUGuOVc3PzRizszN NXTT[o5yW0GQR1XS
SK-MEL-2 NF7WOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nXcWlEPTB;MT63NVc5QSEQvF2= M{PXO3NCVkeHUh?=
NCI-H1155 M17jSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFwN{O2O|Yh|ryP NED4[lBUSU6JRWK=
NCI-H1092 NEL5VW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG3XYJKSzVyPUGuO|YyQDJizszN MYTTRW5ITVJ?
LU-165 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[1d3Y5UUN3ME2xMlg3PDd4IN88US=> MmHUV2FPT0WU
HL-60 NIrK[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTFwOUm5NFgh|ryP M2\0enNCVkeHUh?=
REH MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn71TWM2OD1{LkCwOVgzKM7:TR?= MmTxV2FPT0WU
JVM-2 NXrIXWpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXITWM2OD1{LkC2NVM2KM7:TR?= NFniTGhUSU6JRWK=
MN-60 MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJwMUezNFgh|ryP NUf4XFNxW0GQR1XS
SCC-15 M1KyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJwMkCyO{DPxE1? MlnQV2FPT0WU
SNU-C1 NWjuPWt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrjVHdJUUN3ME2yMlIyOzR|IN88US=> NX\tfYVRW0GQR1XS
SK-MEL-1 M1LCfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\4WGlEPTB;Mj6zNlA1PyEQvF2= NWHsV4lXW0GQR1XS
TGW NEfvNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;zTWM2OD1{LkO1NFI4KM7:TR?= M4n5b3NCVkeHUh?=
CA46 NV\iSmV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkSzTWM2OD1{Lke1PVY4KM7:TR?= MmTWV2FPT0WU
NCI-H23 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S3PGlEPTB;Mj64NFc6OSEQvF2= M1jIPHNCVkeHUh?=
MMAC-SF NE\ZPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYCwd5NHUUN3ME2yMlg3PjJ6IN88US=> M1faXHNCVkeHUh?=
NCI-H2171 NXTydW1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;qTWM2OD1|LkCzOFQ5KM7:TR?= Mn\ZV2FPT0WU
A704 NX;2R|A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfPTo1PUUN3ME2zMlE1OTl2IN88US=> MVXTRW5ITVJ?
DB NGP1TodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHNboNKSzVyPUOuNlU2PzZizszN MkDWV2FPT0WU
NCI-H719 NV3j[GFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f6dGlEPTB;Mz6zNFM5PCEQvF2= M2rZcHNCVkeHUh?=
MC-CAR NITsSFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTNwNUS4NVch|ryP M2rDN3NCVkeHUh?=
SIMA NVPoUpY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TSV2lEPTB;Mz61PFQyPiEQvF2= MXHTRW5ITVJ?
SW872 M3fCc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLNfZAxUUN3ME2zMlc5OTBzIN88US=> MV3TRW5ITVJ?
HCC1187 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTNwN{izNVUh|ryP NFPXcFhUSU6JRWK=
EW-13 M{DrZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;PcopKSzVyPUOuPFM1OTdizszN M4D3U3NCVkeHUh?=
NCI-SNU-1 NEjqdGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHOVXpKSzVyPUSuNlE6QTlizszN NFmyXZFUSU6JRWK=
NCI-H226 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTRwM{O2NFYh|ryP NF;QXXpUSU6JRWK=
RPMI-8866 M3K2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;2dGxKSzVyPUSuN|YxOjlizszN M2T6dXNCVkeHUh?=
OCI-AML2 NV7n[lJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEKwN2dKSzVyPUSuOVUzOyEQvF2= M1\ZUHNCVkeHUh?=
LU-65 NXfIUGhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j2W2lEPTB;ND65N|A{OyEQvF2= NX\P[m82W0GQR1XS
SK-N-DZ NEGy[YZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLqe3VKSzVyPUWuOlM1PjVizszN NULUbW9SW0GQR1XS
NB14 M1rFNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;GZmlEPTB;NT65O|E{PSEQvF2= Mnq0V2FPT0WU
COLO-829 M3:xfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S4UGlEPTB;Nj6zN|M2QSEQvF2= M3LYOnNCVkeHUh?=
MHH-CALL-2 MnjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;CTWM2OD14LkWxOVA5KM7:TR?= MlrvV2FPT0WU
NCI-H1770 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D1fWlEPTB;Nj62OlkxPCEQvF2= Mk\RV2FPT0WU
ECC4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj1e3VKSzVyPU[uPFIyPzlizszN MonWV2FPT0WU
A498 M13DOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PiPWlEPTB;Nj64O|E6OiEQvF2= NFrSV4dUSU6JRWK=
DMS-79 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXLR2ZPUUN3ME23MlA1PTF{IN88US=> NGO5[FNUSU6JRWK=
P30-OHK M{LvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\KTWM2OD15LkKxPVA3KM7:TR?= MlfNV2FPT0WU
D-502MG MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXnTWM2OD15Lkm4N|Yh|ryP NWHKVmlSW0GQR1XS
RCC10RGB NXj4WZlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDXTWM2OD16LkC2Nlgh|ryP MVLTRW5ITVJ?
U-698-M MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC1cVVKSzVyPUiuNlkzOjZizszN NYDRb|V1W0GQR1XS
BB49-HNC NVvv[JFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXRZlhVUUN3ME25MlQzOjZ3IN88US=> NGfrZpdUSU6JRWK=
ES1 NIf1W4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jXfmlEPTB;OT62PFk2PiEQvF2= MnTmV2FPT0WU
MFM-223 NVnkTGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHkVIxoUUN3ME2xNE46QTJ5IN88US=> MY\TRW5ITVJ?
C2BBe1 NFq1NHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PWWGlEPTB;MUGuN|UzOyEQvF2= NYHibYpDW0GQR1XS
EB2 NWDTSoh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jPfGlEPTB;MUKuOlg5OSEQvF2= NHzLS5JUSU6JRWK=
C8166 NHvDUmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTF|LkizNFMh|ryP MX;TRW5ITVJ?
ES3 NGTCRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonETWM2OD1zMz65PVc4KM7:TR?= MkXVV2FPT0WU
NCI-H1650 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrXR2pRUUN3ME2xOk4{PzZ3IN88US=> Ml:3V2FPT0WU
Mo-T MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XaXGlEPTB;MUeuOFAzQSEQvF2= NGDQUIJUSU6JRWK=
NB7 MoO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXxeVRKSzVyPUG3Mlc1PjdizszN MlzUV2FPT0WU
ES7 NH7qbXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTF7LkW1NFch|ryP NVSzOnRCW0GQR1XS
ES5 NGrvPVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4f5d2lEPTB;MkGuO|Y4OSEQvF2= MlXsV2FPT0WU
MSTO-211H MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\uTWM2OD1{MT64PFU5KM7:TR?= Ml;XV2FPT0WU
U-87-MG NIrxeWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:x[2lEPTB;MkWuNVk3PiEQvF2= NXrwUJh4W0GQR1XS
THP-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHpTWM2OD1{OT63NlAyKM7:TR?= NV\3VWpQW0GQR1XS
NB10 NGHYPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTNyLkK2PVQh|ryP NVyyWYoxW0GQR1XS
NH-12 NYP0U5R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nEb2lEPTB;M{OuNlAyPyEQvF2= M{WyOnNCVkeHUh?=
COLO-824 NYfFWmlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PHTGlEPTB;M{SuNVAxPiEQvF2= NEHmb|BUSU6JRWK=
SKM-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLrb|NKSzVyPUO3Mlg1OjJizszN NFTkcY5USU6JRWK=
NCI-H1838 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\QTWM2OD1|OD6zO|k4KM7:TR?= MlO4V2FPT0WU
RL NFnnW5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTN7LkK0O|ch|ryP MVvTRW5ITVJ?
COLO-800 NIjwU2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojOTWM2OD12MD6wO|c{KM7:TR?= M1XOXXNCVkeHUh?=
KG-1 NV3sfpFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTRyLki5OVUh|ryP Mlq4V2FPT0WU
TUR MnfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn3TWM2OD12MT62N|k6KM7:TR?= MkXPV2FPT0WU
LNCaP-Clone-FGC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjYTWM2OD12MT65NFE4KM7:TR?= NWDKRWhmW0GQR1XS
NCI-H322M MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDYTWM2OD12Mj61PVg1KM7:TR?= MXjTRW5ITVJ?
LNCaP  NWfYV21mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG0OpNKSzVyPUmxMlMhdk1? NFvWco8zPTVyNUG3OC=>
C4-2 MlXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fXVWlEPTB;ODDuUS=> M2HSclI2PTB3MUe0
JURKAT MlTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT2TpAyOjRiaB?= NYfu[ndXUUN3ME20NVYvPjZibl2= M2DL[|I1PTF7OUm1
MOLT-4 NFe5eplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3OyPVI1KGh? NFfjcYxKSzVyPUK4OVMvPSCwTR?= M2fZ[lI1PTF7OUm1
REH M3;LWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnXSnkzPCCq NGfnSG9KSzVyPUK4O{43QCCwTR?= MVSyOFUyQTl7NR?=
NALM-6 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWyNlQhcA>? MnT2TWM2OD1|NEOzNEBvVQ>? NWLONHVtOjR3MUm5PVU>
RS 4;11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[yOEBp MXPJR|UxRTVzOT6wOUBvVQ>? M1yycVI1PTF7OUm1
697 M4m4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzTNlQhcA>? MWnJR|UxRTJzMEeuNUBvVQ>? M134N|I1PTF7OUm1
SIL-ALL NHr0SmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTQUm8zPCCq NVLNcFgyUUN3ME2xPVkvPzdibl2= NIrmbGUzPDVzOUm5OS=>
CEM NUjq[3VoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX[yOEBp NWHGd2t7UUN3ME21Nk4yQCCwTR?= M4jx[|I1PTF7OUm1
P12 MnLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u2eVI1KGh? Mn3iTWM2OD1|OT6yO{BvVQ>? Mnr3NlQ2OTl7OUW=
NALM-16 NXzEUJlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjxNYxlOjRiaB?= NEPYNYJKSzVyPUm2MlI5KG6P MlfiNlQ2OTl7OUW=
JURKAT MnPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTybXk1QCCq MUnJR|UxRTF2Lki0JI5O NUjoN2JOOjR3MUm5PVU>
MOLT-4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqzV5o1QCCq NEXOWmNKSzVyPUK2MlYhdk1? Mo\KNlQ2OTl7OUW=
REH MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUm0PEBp MXXJR|UxRTR2LkexJI5O NFP0OHQzPDVzOUm5OS=>
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C2 MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nIOFEuOTByMDDuUS=> NWPuRXlKPzJiaB?= NX;YOVlkcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n MWmyNVI1OjF6OR?=
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... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 21 mg/mL (40.25 mM)
エタノール 100 mg/mL (191.69 mM)
<1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

カスタマーフィードバック (10)


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Source Cancer Cell , 2010, 18, 641–654. BI 2536 purchased from Selleck
Method Immunohistochemical analysis
Cell Lines SCID mice
Concentrations
Incubation Time
Results Control tumors grow exponentially, whereas genetic ablation of Cdc20 results in complete tumor regression in about 10 days. In comparison, treatment with taxol, vincristine, and BI2536 only induces partial responses ( Figure C). In agreement with the data observed in vitro, immunohistochemical analysis of samples taken 3 days after the first treatment indicates lack of proliferation (as measured by BrdU incorporation) and massive apoptosis in Cdc20 null cells, whereas all other samples maintain significant levels of proliferation and reduced apoptotic markers ( Figure D)

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Source Nat Cell Biol, 2011, 13, 1265-71. BI 2536 purchased from Selleck
Method cold-stable assay, Immunological methods
Cell Lines RPE1 cells
Concentrations 40 nM
Incubation Time 45 min
Results To examine whether B56-PP2A attenuates the signalling of kinetochore kinases other than Aurora B, we examined Plk1. Remarkably, wash-in of the Plk1 inhibitor BI2536 also restored K-fibres in B56-PP2A-siRNA cells.

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Western blot
Cell Lines NB TICs
Concentrations 10-100 nM
Incubation Time 16/24 h
Results The cyclin-dependent kinase inhibitor p21, a newly identified substrate of PLK1, also accumulated in BI 2536-treated NB TICs (Fig. C). Finally, PLK1 kinase activity was inhibited following treatment of NB TICs with BI 2536, as demonstrated by anti-PLK1 immunoprecipitiation followed by in vitro PLK1 kinase assay ( Fig. D)

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Trypan blue exclusion, Western blot
Cell Lines NB TICs
Concentrations 10/30/100 nmol/L
Incubation Time 24/48/72 h
Results We observed a significant difference in viable cell numbers in BI2536-treated samples, as compared with DMSO (vehicle)-treated cells, at 24 hours posttreatment. The difference became more pronounced with time, such that at 72 hours there were only approximately 20% viable cells following treatment with 10 nmol/L BI 2536 and approximately 2% to 5% viable cells following treatment with 30 and 100 nmol/L as compared with DMSO-treated cells(Fig. A). At 24 hours, BI 2536-treated cells gradually accumulated cleaved PARP, in contrast to DMSO-treated cells, suggesting induction of apoptosis ( Fig. B).

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5-25 mg/kg
Incubation Time 0-24 d
Results As shown in Figure A,tumor growth was significantly inhibited following administration of the third cycle of BI 2536 therapy. When mice were administered 25 mg/ kg weekly on 2 consecutive days for a total of only 2 cycles, tumor growth was inhibited after the second cycle ( Fig. B)

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5 mg/kg
Incubation Time 0-60 d
Results We examined a combination of a low dose of BI 2536 (12.5 mg/kg) with a low dose of irinotecan (10 mg/kg), a topoisomerase inhibitor with demonstrated activity in phase II clinical trials in relapsed NB. Single-agent treatment with low-dose of either BI 2536 or irinotecan was comparably efficacious, resulting in significant growth inhibition, as compared with vehicle-treated animals.

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Source J Invest Dermatol, 2011, 131, 1886–1895. BI 2536 purchased from Selleck
Method MTT assay
Cell Lines M14 cell lines, WM-115 cell lines
Concentrations 1-20 nM
Incubation Time
Results Specific inhibition of Plk-1 using the commercially available inhibitor BI 2536 led to a dose- and time-dependent decrease in human melanoma cell viability.

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Source J Biol Chem, 2012, 287(21), 17088-99. BI 2536 purchased from Selleck
Method Cell death assay
Cell Lines HeLa cells
Concentrations 0 -120 nM
Incubation Time 72 h
Results In HeLa cells lacking GRK5, there was an~4.5-fold decrease in the EC50 of BI 2536-mediated cell death (control shRNA, 18.9 ?.2 nM; GRK5 shRNA, 4.1?.1 nM, n = 6, p < 0.05) (Fig. A). Similar to BI 2536, cells lacking GRK5 were ~4.5-fold more sensitive to GSK461364 compared with control cells (EC50 for control shRNA cells, 17.0 ?4.4 nM;EC50 for GRK5-shRNA cells, 3.8 ?0.7 nM, n = 4, p < 0.05).

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Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 0-10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

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Rating
Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

文献中の引用 (49)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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