BI 2536 化学構造
分子量: 521.66

高品質保証

文献中の引用(50)

カスタマーフィードバック(10)

Quality Control & MSDS

製品説明

  • Compare PLK Inhibitors
    PLK製品生物活性の比較
  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 M2XYNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEC3O|Yh|ryP NXHndFNyW0GQR1XS
ACN M3zoOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\KN21FUUN3ME2wMlAxQDR|IN88US=> NVP4dmc6W0GQR1XS
TE-8 MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zkOWlEPTB;MD6wNFk1OSEQvF2= M3fheXNCVkeHUh?=
LC-2-ad MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HEcGlEPTB;MD6wNVA6OyEQvF2= NGT0OGZUSU6JRWK=
ALL-PO M3L0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HaTWlEPTB;MD6wNVMh|ryP NFPhOHJUSU6JRWK=
EW-16 NWDuXY5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEGzN|Yh|ryP NWnBcZh6W0GQR1XS
KM12 NX;mNnp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;zendKSzVyPUCuNFE{PDhizszN MkLVV2FPT0WU
GI-1 M3XpXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK0[4ZKSzVyPUCuNFE{QDNizszN NWH6enI6W0GQR1XS
LS-411N M4DqPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jVe2lEPTB;MD6wNVQxPyEQvF2= MWjTRW5ITVJ?
ES8 NH3OXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfnNIRKSzVyPUCuNFE1QTRizszN NFHJNoNUSU6JRWK=
SNU-C2B MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\qb3l4UUN3ME2wMlAyPTJ4IN88US=> M{fpO3NCVkeHUh?=
CESS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLPXpl6UUN3ME2wMlAyPjB{IN88US=> MoH3V2FPT0WU
697 NFnDNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPKXlFKSzVyPUCuNFE3PjhizszN NGX4U3ZUSU6JRWK=
NCI-H1963 MlzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrIdmV6UUN3ME2wMlAyPjd|IN88US=> MlKxV2FPT0WU
IA-LM NVjuVIpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMEG2PFgh|ryP MXvTRW5ITVJ?
SW954 MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEG3NFUh|ryP MVPTRW5ITVJ?
RL95-2 NUXCWW9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjIbFRKSzVyPUCuNFE4OzhizszN MXLTRW5ITVJ?
LXF-289 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDETWM2OD1yLkCxO|ch|ryP MmjpV2FPT0WU
OCUB-M MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7E[npKSzVyPUCuNFE5OjZizszN M4izc3NCVkeHUh?=
RKO M2fQ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LyT2lEPTB;MD6wNVk5PyEQvF2= Mn6wV2FPT0WU
LOUCY NV3zeGVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEKwOUDPxE1? NFXpS21USU6JRWK=
NOS-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH1RlBKSzVyPUCuNFIxQTNizszN NIr4cppUSU6JRWK=
A4-Fuk MkPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPBOVhIUUN3ME2wMlAzOjF6IN88US=> NIn2eWRUSU6JRWK=
A388 Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrJTWM2OD1yLkCyNlI4KM7:TR?= NYK2eI9GW0GQR1XS
TE-9 NUDofHE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;aT5VKSzVyPUCuNFIzPjFizszN MlHZV2FPT0WU
KURAMOCHI NVPXbIdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP6dmtKSzVyPUCuNFIzQDVizszN NELaR4RUSU6JRWK=
KALS-1 MnT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j4WmlEPTB;MD6wNlM{QCEQvF2= MUPTRW5ITVJ?
HOP-62 NGX2NGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7BTWM2OD1yLkCyOFIh|ryP MUTTRW5ITVJ?
RPMI-8402 NWW4U4dVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\NTWM2OD1yLkCyOVA5KM7:TR?= NV;0fFF2W0GQR1XS
TE-1 MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIWzW2xKSzVyPUCuNFI2OTJizszN M1fRfnNCVkeHUh?=
CCRF-CEM MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEK1OFMh|ryP MmnTV2FPT0WU
HUTU-80 M3PCOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH6TWM2OD1yLkCyOlI1KM7:TR?= MVfTRW5ITVJ?
NCI-H1648 NY[4WXpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEK2OFch|ryP NWLPToxJW0GQR1XS
HCE-4 NHXmOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HNNGlEPTB;MD6wNlY5OiEQvF2= NFXCVYVUSU6JRWK=
ETK-1 MoXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHTTWM2OD1yLkCyO|M3KM7:TR?= NXXV[Y1jW0GQR1XS
TE-15 NULV[JVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrGTWM2OD1yLkCyO|M5KM7:TR?= Mn7DV2FPT0WU
BE-13 Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW3S4cyUUN3ME2wMlAzPzRizszN MULTRW5ITVJ?
KE-37 M2HwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XofGlEPTB;MD6wNlc1OSEQvF2= NYfLXHo{W0GQR1XS
NCI-H1355 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3lcIdMUUN3ME2wMlAzPzh|IN88US=> MVvTRW5ITVJ?
TE-11 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjzTWM2OD1yLkCyPFA6KM7:TR?= NU\sZYtrW0GQR1XS
BL-70 NHHEV|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojmTWM2OD1yLkCyPFU4KM7:TR?= NV3wRnV2W0GQR1XS
ES6 M324OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEK4PFEh|ryP MYDTRW5ITVJ?
GT3TKB NVjBZpdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M370U2lEPTB;MD6wNlk2OyEQvF2= NFPGOI5USU6JRWK=
LB647-SCLC MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMEOxPVUh|ryP NGXlcJVUSU6JRWK=
NB13 MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe5[plKSzVyPUCuNFM{OTZizszN MVXTRW5ITVJ?
ST486 M1PRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPkTWM2OD1yLkCzN|M4KM7:TR?= NV3ndmR3W0GQR1XS
NCI-H82 Mke3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMEOzOFMh|ryP MUfTRW5ITVJ?
NTERA-S-cl-D1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjnVIFPUUN3ME2wMlA{Ozl7IN88US=> NF;QdoFUSU6JRWK=
ES4 MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv5TWM2OD1yLkCzOFY{KM7:TR?= NGn0e4lUSU6JRWK=
SK-NEP-1 NEXhOYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMEO0PVkh|ryP MUXTRW5ITVJ?
Becker MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXNTWM2OD1yLkCzOVU2KM7:TR?= Mme5V2FPT0WU
A101D NVuxVppST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEmy[nNKSzVyPUCuNFM4PDhizszN NIrmN|RUSU6JRWK=
SK-UT-1 NVu2NXBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn31TWM2OD1yLkCzO|c1KM7:TR?= NVLqcZRLW0GQR1XS
SW982 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLXOmJ7UUN3ME2wMlA{PzlizszN NWrLfodlW0GQR1XS
TE-10 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXQPZNKSzVyPUCuNFQxPDZizszN MnXLV2FPT0WU
OVCAR-4 NHnNXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfkTWM2OD1yLkC0NFU6KM7:TR?= M1Ptc3NCVkeHUh?=
KP-N-YS M3HrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfFTWM2OD1yLkC0NFg2KM7:TR?= MoqyV2FPT0WU
BL-41 Mkm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f6WWlEPTB;MD6wOFEzPSEQvF2= MnHjV2FPT0WU
MZ1-PC NUjPdIlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHiVmlKSzVyPUCuNFQyOjdizszN M3ziVnNCVkeHUh?=
PF-382 NH;WeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3OTWM2OD1yLkC0NVk5KM7:TR?= MofhV2FPT0WU
MOLT-13 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorDTWM2OD1yLkC0NlM5KM7:TR?= NHf6PWZUSU6JRWK=
HCC1599 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XnUWlEPTB;MD6wOFI2QCEQvF2= MkDSV2FPT0WU
IST-MEL1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjoOpVKSzVyPUCuNFQ1PDJizszN M4rScXNCVkeHUh?=
LU-139 NXnJZVZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnqTWM2OD1yLkC0OFQzKM7:TR?= NIfZN2VUSU6JRWK=
MS-1 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP6TZJKSzVyPUCuNFQ4ODFizszN MlTQV2FPT0WU
MFH-ino MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEWwNFMh|ryP M4LHbnNCVkeHUh?=
IMR-5 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEWwNlEh|ryP NXXBPXU1W0GQR1XS
TE-5 NIfVZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlKwTWM2OD1yLkC1NFY{KM7:TR?= NVvITJYxW0GQR1XS
DJM-1 MoO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHzWYdKSzVyPUCuNFUyPDJizszN MYHTRW5ITVJ?
NB17 M{fYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu3VGVKSzVyPUCuNFUzODdizszN M1rucnNCVkeHUh?=
KARPAS-45 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInzcZFKSzVyPUCuNFU{PThizszN NXrEcXlWW0GQR1XS
TGBC1TKB MkDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPzdpJWUUN3ME2wMlA2PDB3IN88US=> MoPOV2FPT0WU
ML-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3ITWM2OD1yLkC1OFE1KM7:TR?= MXvTRW5ITVJ?
no-10 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fKSmlEPTB;MD6wOVQ4PCEQvF2= MYLTRW5ITVJ?
CTV-1 MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnrc2JKSzVyPUCuNFU2ODJizszN Mnu2V2FPT0WU
SJSA-1 M{LaNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz5VpVKSzVyPUCuNFU2OiEQvF2= MYnTRW5ITVJ?
HC-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LMfmlEPTB;MD6wOVU6PyEQvF2= MlHwV2FPT0WU
TE-12 NFXwRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEW2NVMh|ryP MVnTRW5ITVJ?
KY821 NVPpTGhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvPPGwyUUN3ME2wMlA2PjN{IN88US=> MnHPV2FPT0WU
TALL-1 Ml7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq3UFdKSzVyPUCuNFU4ODhizszN NVKxT4pNW0GQR1XS
DEL M2DUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjjXoszUUN3ME2wMlA2PzB7IN88US=> MnzYV2FPT0WU
TE-6 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\WcG5KUUN3ME2wMlA2PzJ{IN88US=> M1jDSHNCVkeHUh?=
SK-LMS-1 NYT5eW5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSwOZVFUUN3ME2wMlA2QDB3IN88US=> Ml;UV2FPT0WU
EW-1 Mki3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T4SmlEPTB;MD6wOVg{PyEQvF2= MkXQV2FPT0WU
8-MG-BA M4ixUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3LfppKSzVyPUCuNFU5PTFizszN MmHKV2FPT0WU
NALM-6 M3nPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrLO|BYUUN3ME2wMlA2QTd|IN88US=> NVrRTVU5W0GQR1XS
LB771-HNC Ml24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PxUmlEPTB;MD6wOVk4QSEQvF2= MV;TRW5ITVJ?
HT-144 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\Re5F3UUN3ME2wMlA3OTNizszN NFO0cIJUSU6JRWK=
KM-H2 MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXadWJKSzVyPUCuNFYzOjFizszN MVfTRW5ITVJ?
SF268 NXPsbGxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLQZ|R4UUN3ME2wMlA3Ojh4IN88US=> MXnTRW5ITVJ?
RS4-11 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfxSWVGUUN3ME2wMlA3OzB2IN88US=> MkTKV2FPT0WU
MHH-PREB-1 NFGyOYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPGcWdKSzVyPUCuNFY{OTlizszN MWPTRW5ITVJ?
ATN-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXMTWM2OD1yLkC2N|Q2KM7:TR?= NGTufYRUSU6JRWK=
BB30-HNC M2DoPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXFOVdKSzVyPUCuNFY1OzZizszN M2TyTHNCVkeHUh?=
CPC-N M1np[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDDPGtKSzVyPUCuNFY2OjRizszN MXjTRW5ITVJ?
NB1 MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFK5clhKSzVyPUCuNFY3OTNizszN Mo[wV2FPT0WU
KS-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTrTW1tUUN3ME2wMlA3PzR6IN88US=> MnHnV2FPT0WU
RXF393 M2LNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL6NW9NUUN3ME2wMlA3PzZ2IN88US=> M37iZ3NCVkeHUh?=
IST-SL2 NF76NI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDFV2JKSzVyPUCuNFcxODRizszN MX;TRW5ITVJ?
GI-ME-N MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPq[XNKSzVyPUCuNFczQDZizszN NHzNWZdUSU6JRWK=
VA-ES-BJ NIjiPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMEe0O|Uh|ryP M{LzNnNCVkeHUh?=
NCI-H1581 NV;LRXhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7iZ3hZUUN3ME2wMlA4PDd6IN88US=> NXnQPZNDW0GQR1XS
U-266 Ml3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDNTFNKSzVyPUCuNFc1QTdizszN NX3EbG5xW0GQR1XS
DMS-114 MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWraU4QyUUN3ME2wMlA4PTJ6IN88US=> NEHLUFRUSU6JRWK=
NCI-H187 MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEe3NlYh|ryP MVrTRW5ITVJ?
SW962 MnTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEe4N|kh|ryP MkOwV2FPT0WU
MONO-MAC-6 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\ITWM2OD1yLkC3PVg3KM7:TR?= MVjTRW5ITVJ?
MOLT-16 MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPlXYhHUUN3ME2wMlA5OTJzIN88US=> M4fx[XNCVkeHUh?=
KNS-42 M3rwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37iSWlEPTB;MD6wPFE3OSEQvF2= NEH5bYNUSU6JRWK=
CMK M{TObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEiyNlUh|ryP MXXTRW5ITVJ?
Ramos-2G6-4C10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEiyNlUh|ryP NV;a[2M1W0GQR1XS
Daudi MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETLOHRKSzVyPUCuNFgzPTZizszN NYTtdY9YW0GQR1XS
NCI-H510A MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfJXpdKSzVyPUCuNFg{OzZizszN M3[zU3NCVkeHUh?=
LB831-BLC MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;PTWM2OD1yLkC4OVYyKM7:TR?= M{\Rd3NCVkeHUh?=
HEL M3G3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HIOWlEPTB;MD6wPFY3QCEQvF2= NVv3TWpKW0GQR1XS
LU-134-A NF3PeoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTkS3BRUUN3ME2wMlA5PzB6IN88US=> M3Kz[3NCVkeHUh?=
NCI-H1694 NWLGc3N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEi3OFQh|ryP NY\nWWg2W0GQR1XS
KGN Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\kRYFwUUN3ME2wMlA5PzV7IN88US=> M4rzVHNCVkeHUh?=
A253 M1PuU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITZbldKSzVyPUCuNFg5OjJizszN MkO0V2FPT0WU
DG-75 NG\aVJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\tSYpKSzVyPUCuNFg6OjJizszN MX;TRW5ITVJ?
MOLT-4 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLLTWM2OD1yLkC4PVg{KM7:TR?= MYDTRW5ITVJ?
NCI-SNU-5 NYXLNng2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfBTWM2OD1yLkC5NlU5KM7:TR?= NX3Re3R[W0GQR1XS
ONS-76 MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\HeWlEPTB;MD6wPVI4PiEQvF2= NWPrZ29zW0GQR1XS
NCI-H446 NUj6PXNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z1[mlEPTB;MD6wPVQ3OiEQvF2= MUHTRW5ITVJ?
COR-L279 NYW2T3ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTyXnFEUUN3ME2wMlA6PTV4IN88US=> NWXNbm9qW0GQR1XS
Calu-6 M{XRXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfIOo9rUUN3ME2wMlA6PTl6IN88US=> MWPTRW5ITVJ?
BC-3 MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi5TWM2OD1yLkC5OlYzKM7:TR?= Mny1V2FPT0WU
NCI-H2126 MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHCTWM2OD1yLkC5O|kyKM7:TR?= MY\TRW5ITVJ?
NCI-H1882 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfKUYdOUUN3ME2wMlA6QDB7IN88US=> NUjoZpZNW0GQR1XS
BB65-RCC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fafmlEPTB;MD6xNFI6PCEQvF2= NWDqPXJtW0GQR1XS
DU-4475 MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDWUG5oUUN3ME2wMlExPDB5IN88US=> NX:0[HJwW0GQR1XS
NCI-H526 M2rT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHW2O4tKSzVyPUCuNVA1PCEQvF2= NWHKW|Y1W0GQR1XS
NEC8 NVvzepJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXTVWd2UUN3ME2wMlExPTJ3IN88US=> MV3TRW5ITVJ?
NCI-H1304 MoD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DXV2lEPTB;MD6xNFU6PCEQvF2= M1rpOnNCVkeHUh?=
L-540 M4niSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG4TWM2OD1yLkGwO|A5KM7:TR?= NFyydGtUSU6JRWK=
NCI-SNU-16 NIG1O2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVryNI1FUUN3ME2wMlExPzR{IN88US=> MXLTRW5ITVJ?
HD-MY-Z MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PJO2lEPTB;MD6xNFg2PiEQvF2= MXvTRW5ITVJ?
K-562 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zD[2lEPTB;MD6xNFg2QCEQvF2= M1rN[nNCVkeHUh?=
JAR MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMUC5NlUh|ryP NXrDUmlUW0GQR1XS
MZ2-MEL NVL6R3ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMUGwOUDPxE1? NUT1eWRlW0GQR1XS
L-363 NIXze5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMUGwO|kh|ryP NF3LU4FUSU6JRWK=
BV-173 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fQRmlEPTB;MD6xNVI1OyEQvF2= Mo\iV2FPT0WU
NCI-H524 NWHsdoptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfNS4RKSzVyPUCuNVEzPzRizszN MonKV2FPT0WU
EoL-1-cell NEnjZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XBdGlEPTB;MD6xNVY4OiEQvF2= MlHoV2FPT0WU
K052 M33L[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK5NVNtUUN3ME2wMlEyPzF{IN88US=> MVLTRW5ITVJ?
TK10 NGjE[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnCTWM2OD1yLkGxO|I5KM7:TR?= MmC5V2FPT0WU
KU812 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;Me2lEPTB;MD6xNlA1PCEQvF2= MYTTRW5ITVJ?
RPMI-8226 NVPlXWp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMUKwOVIh|ryP NFfkWIpUSU6JRWK=
MZ7-mel M3TtU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjDdYI4UUN3ME2wMlEzOjN5IN88US=> MorMV2FPT0WU
SK-PN-DW NIH4[mtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;DOoN{UUN3ME2wMlEzOjh5IN88US=> NVH2fZZGW0GQR1XS
SR M3rVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS0eHNKSzVyPUCuNVI1PDFizszN NYrGWlVOW0GQR1XS
RPMI-6666 NVr0enQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MliyTWM2OD1yLkGyO|Q{KM7:TR?= NXrsPFhGW0GQR1XS
no-11 NF7vSmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4WxW2lEPTB;MD6xNlg3QSEQvF2= NXLwbGk{W0GQR1XS
EW-3 M3:xNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e3XWlEPTB;MD6xNlg6OyEQvF2= NXXGVo9VW0GQR1XS
LAMA-84 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu4TWM2OD1yLkGzNVg4KM7:TR?= M3jLOnNCVkeHUh?=
HT MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTvRYtKSzVyPUCuNVM2PzRizszN NYrhc|BmW0GQR1XS
KP-N-RT-BM-1 NI\tPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID2UVNKSzVyPUCuNVM3OTJizszN M4TSTHNCVkeHUh?=
NCI-H747 NITzU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7ZeoVKSzVyPUCuNVM4KM7:TR?= Mny0V2FPT0WU
NCCIT NH64bmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnThTWM2OD1yLkGzPVM6KM7:TR?= MljXV2FPT0WU
MLMA MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj3PGVKSzVyPUCuNVQyPjdizszN MnfoV2FPT0WU
LP-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPXT|lGUUN3ME2wMlE1OjRizszN NVP4UJRwW0GQR1XS
CAL-148 NECxWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDmS3hnUUN3ME2wMlE1PDh|IN88US=> M2SzbnNCVkeHUh?=
GB-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;De41KSzVyPUCuNVQ2OjZizszN NYPLSo1mW0GQR1XS
COR-L88 NXP3cIhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\QTWM2OD1yLkG0PFAzKM7:TR?= NHfZclRUSU6JRWK=
NKM-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXlTWM2OD1yLkG0PVA3KM7:TR?= MV\TRW5ITVJ?
NB5 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P5fmlEPTB;MD6xOVQ3OiEQvF2= MXvTRW5ITVJ?
SH-4 M1\Zfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMUW0OlYh|ryP NIPVb5BUSU6JRWK=
EM-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfIbYl7UUN3ME2wMlE2PDZ5IN88US=> MmnKV2FPT0WU
TGBC24TKB Mn;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLsTWM2OD1yLkG1OlU6KM7:TR?= NULPeIdUW0GQR1XS
SCLC-21H NWPMT|JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMUW3NFIh|ryP M4SyR3NCVkeHUh?=
COLO-684 M{nPb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHzc2ZWUUN3ME2wMlE2PzJzIN88US=> M33GfHNCVkeHUh?=
KINGS-1 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fmU2lEPTB;MD6xOVkyKM7:TR?= M1PS[nNCVkeHUh?=
LS-123 NUe0dItwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i3[mlEPTB;MD6xOVkyPyEQvF2= MXPTRW5ITVJ?
MC116 NV3FSGV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mon6TWM2OD1yLkG2NVU5KM7:TR?= NGX6RphUSU6JRWK=
SU-DHL-1 MoLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\TXmlEPTB;MD6xOlIxPiEQvF2= NEPxTGtUSU6JRWK=
NCI-H64 M1r5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LwcGlEPTB;MD6xOlM1PyEQvF2= MWHTRW5ITVJ?
HCE-T NFjOdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnlTWM2OD1yLkG2OVA1KM7:TR?= Mn32V2FPT0WU
LOXIMVI NWHiV3hWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvWTWM2OD1yLkG2PVQ6KM7:TR?= NGK1clNUSU6JRWK=
ARH-77 M{nzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMUezO|kh|ryP NWjsWpJKW0GQR1XS
DOHH-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf4XI9sUUN3ME2wMlE4Pjd{IN88US=> NYDWcFlNW0GQR1XS
COLO-320-HSR NWHXfZhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH32cpRKSzVyPUCuNVgyPTRizszN NWqxO3M2W0GQR1XS
NB6 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrYZplKSzVyPUCuNVg2PjZizszN NHqxSWhUSU6JRWK=
L-428 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUi4NVMh|ryP M1HUeXNCVkeHUh?=
SNB75 NETXR4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHxTWM2OD1yLkG4PFI1KM7:TR?= MVPTRW5ITVJ?
NCI-H2141 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3VTWM2OD1yLkG5NFEyKM7:TR?= M{XQe3NCVkeHUh?=
KARPAS-299 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXlTWM2OD1yLkG5NlQyKM7:TR?= MWDTRW5ITVJ?
LC4-1 NXu4THF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLUWmxKSzVyPUCuNVk2ODJizszN M1PSUXNCVkeHUh?=
UACC-257 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL6TWM2OD1yLkG5PVQ4KM7:TR?= M4DIW3NCVkeHUh?=
EVSA-T NYjwWIlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnwRodxUUN3ME2wMlIxOzF{IN88US=> MmrWV2FPT0WU
JiyoyeP-2003 M{fKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnR[otFUUN3ME2wMlIxPDd5IN88US=> NE\1NWJUSU6JRWK=
NCI-H720 NGDER5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT1cpdLUUN3ME2wMlIxPTJ3IN88US=> NILD[ZpUSU6JRWK=
GAK MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMkGxPFkh|ryP NYLnbGlLW0GQR1XS
HH NV63eZdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS3OY5zUUN3ME2wMlIyPDB3IN88US=> MX;TRW5ITVJ?
NCI-H1436 NVnoZWRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjoTWM2OD1yLkKxOFY1KM7:TR?= MUPTRW5ITVJ?
GR-ST MkmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXHRWFTUUN3ME2wMlIyPDh6IN88US=> M2XUbnNCVkeHUh?=
BC-1 NES4SlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTiTWM2OD1yLkKyOlE3KM7:TR?= NWnDdlg2W0GQR1XS
SIG-M5 NHL3T2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LLTmlEPTB;MD6yNlczPyEQvF2= M1fIU3NCVkeHUh?=
NCI-H345 M2fDZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMkO4NFUh|ryP Ml\MV2FPT0WU
OPM-2 NFTSR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMkO4PFIh|ryP M4GzSXNCVkeHUh?=
LB1047-RCC M4HGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvId4t2UUN3ME2wMlI1PDFizszN M17idXNCVkeHUh?=
CTB-1 NFKzd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvYbI1WUUN3ME2wMlI1PDl|IN88US=> NV34W3dzW0GQR1XS
A3-KAW NFfEPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMkWzOFEh|ryP MlvOV2FPT0WU
SF126 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne3TWM2OD1yLkK1N|g{KM7:TR?= MnrlV2FPT0WU
KARPAS-422 NIju[pFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DSdWlEPTB;MD6yOVQ{PSEQvF2= MU\TRW5ITVJ?
MEG-01 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX4eHVKSzVyPUCuNlU3PzNizszN M2q3Z3NCVkeHUh?=
NCI-H209 M3e3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH1TWM2OD1yLkK2N|c1KM7:TR?= MnHrV2FPT0WU
SBC-1 M1X5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXITWM2OD1yLkK2OUDPxE1? M1ize3NCVkeHUh?=
K5 M4\SUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHMVYhKSzVyPUCuNlY6QDRizszN M4nLN3NCVkeHUh?=
QIMR-WIL NHXqZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[3[GlEPTB;MD6yO|E2PSEQvF2= M{HkT3NCVkeHUh?=
NMC-G1 NWPJRnVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMkiyNVch|ryP NGrJOWNUSU6JRWK=
IST-MES1 NI\IXFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLzTWM2OD1yLkK5NlM5KM7:TR?= NIL6V2dUSU6JRWK=
SW684 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH3TWM2OD1yLkOwNFQ4KM7:TR?= MmSzV2FPT0WU
MV-4-11 M3zuOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;iTWM2OD1yLkOwO|g5KM7:TR?= NH20XZpUSU6JRWK=
LAN-6 M3L1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjaOIw2UUN3ME2wMlMyPTd{IN88US=> NHPBbYNUSU6JRWK=
RH-1 M1PsfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXFb3o{UUN3ME2wMlMyQDdzIN88US=> M3rM[HNCVkeHUh?=
CP66-MEL NHfLPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ntTWlEPTB;MD6zNVg4QCEQvF2= MXXTRW5ITVJ?
EC-GI-10 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUntdVVuUUN3ME2wMlMzQTh5IN88US=> M4e4VnNCVkeHUh?=
GDM-1 NFP2OmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[yWohHUUN3ME2wMlM{ODV7IN88US=> M3qyWXNCVkeHUh?=
IST-SL1 NXn3OoZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PpU2lEPTB;MD6zOFkyPCEQvF2= NYH6NmZZW0GQR1XS
KMOE-2 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvvVpE4UUN3ME2wMlM2OTd3IN88US=> Mk\UV2FPT0WU
OS-RC-2 NITMdmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHCNm1KSzVyPUCuN|U2PDRizszN MkT6V2FPT0WU
HDLM-2 NVP4WI1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LJ[GlEPTB;MD6zO|gyPCEQvF2= NUjUZYx2W0GQR1XS
DSH1 NFTLXHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLZTWM2OD1yLkO4OlMyKM7:TR?= MVrTRW5ITVJ?
LS-1034 Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XmemlEPTB;MD6zPFk2PCEQvF2= MWDTRW5ITVJ?
LB373-MEL-D NH[0bFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwM{mxPVch|ryP MX3TRW5ITVJ?
GOTO NYroUFlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwNEKxNVgh|ryP NXzlVnNyW0GQR1XS
MRK-nu-1 NGjiU25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nJWmlEPTB;MD60NlIxPSEQvF2= Mo\mV2FPT0WU
SK-MM-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELUbGZKSzVyPUCuOFM1PDJizszN NVj3NFBLW0GQR1XS
BOKU NHy4cZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwNEO3PVIh|ryP MXfTRW5ITVJ?
NOMO-1 M2\lb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT3d|RKSzVyPUCuOFM5PiEQvF2= NIjUOlNUSU6JRWK=
J-RT3-T3-5 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\uTWM2OD1yLkS0PFc5KM7:TR?= MUHTRW5ITVJ?
COLO-668 NGTZW5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkGwTWM2OD1yLkS1OlY5KM7:TR?= M33KO3NCVkeHUh?=
SF539 M4L0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwNEi2PFQh|ryP MmHBV2FPT0WU
LB2518-MEL NYXsR5VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLkXlVKSzVyPUCuOFk4ODNizszN MmnOV2FPT0WU
TE-441-T M2G4Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\xVGlEPTB;MD61NFEzKM7:TR?= MkL1V2FPT0WU
MDA-MB-134-VI NVXZTXVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPjOXM1UUN3ME2wMlUxQTJzIN88US=> MYDTRW5ITVJ?
SCC-3 MnPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHQTZBKSzVyPUCuOVE5PzNizszN NVHVb4hIW0GQR1XS
KLE NX;wZYRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7iS29KSzVyPUCuOVIyPzFizszN M3rFeHNCVkeHUh?=
LB2241-RCC NULTZW1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrETWM2OD1yLkWyOVI2KM7:TR?= MVfTRW5ITVJ?
NCI-H1417 MlPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPTTWM2OD1yLkWzOFM2KM7:TR?= NGqzOWZUSU6JRWK=
NCI-H2081 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\vZmQ2UUN3ME2wMlU5PjFzIN88US=> MYLTRW5ITVJ?
NCI-H1522 M2\JOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3SSpNiUUN3ME2wMlU6Ozh|IN88US=> MYHTRW5ITVJ?
NCI-H889 NV\CVIY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTLeXBKSzVyPUCuOVk5PDRizszN NU\ZS2FqW0GQR1XS
CGTH-W-1 Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXVWWlQUUN3ME2wMlYxPzV3IN88US=> NIPJdHVUSU6JRWK=
EB-3 M3TXc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwNkGxOVMh|ryP M3XLS3NCVkeHUh?=
D-336MG NYTLbpU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwNkG3PVEh|ryP MUjTRW5ITVJ?
LC-1F MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\QTWM2OD1yLk[yOVkzKM7:TR?= MlrNV2FPT0WU
MHH-NB-11 Mlu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwNkO4NFEh|ryP NE\JeZRUSU6JRWK=
SK-N-FI MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwNkO5NUDPxE1? NVjhbIlCW0GQR1XS
NCI-H69 NUnmTVZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\5W2lEPTB;MD62OFg4QSEQvF2= NFrzc29USU6JRWK=
SCH M4nZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHXTlFKSzVyPUCuOlYxOjNizszN MnTvV2FPT0WU
LS-513 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{W3RmlEPTB;MD62O|I2QSEQvF2= MnXKV2FPT0WU
CP67-MEL M3m5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH0flBKSzVyPUCuOlc2QTZizszN MofvV2FPT0WU
GCIY NHPldXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\iTWM2OD1yLkewN|Y{KM7:TR?= MWHTRW5ITVJ?
SHP-77 M121cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rhZ2lEPTB;MD63NFc{PCEQvF2= NUfDe3JbW0GQR1XS
EHEB MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHsOWM6UUN3ME2wMlcyQDV2IN88US=> Mm\6V2FPT0WU
D-247MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f0O2lEPTB;MD63N|I{OiEQvF2= NHu4N49USU6JRWK=
Raji MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rNZmlEPTB;MD63OFk5QSEQvF2= NWPBTIM3W0GQR1XS
MPP-89 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnSc2xCUUN3ME2wMlc2QTd6IN88US=> M3rKV3NCVkeHUh?=
EKVX MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwN{mwO|Mh|ryP M2DmUHNCVkeHUh?=
HCC2218 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwN{mxN|Eh|ryP NV[yN4Y{W0GQR1XS
KNS-81-FD MkX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjqWoRzUUN3ME2wMlgyODFzIN88US=> MVHTRW5ITVJ?
HCC2157 MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwOES5OVEh|ryP MULTRW5ITVJ?
BT-474 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\sTWM2OD1yLki4PFU1KM7:TR?= NYq3NZNDW0GQR1XS
NCI-H748 NX[2b5ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXhTWM2OD1yLkmxNkDPxE1? MWfTRW5ITVJ?
EW-24 NH\xVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwOUKwNFIh|ryP MY\TRW5ITVJ?
D-263MG Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmToTWM2OD1yLkm0OVEzKM7:TR?= NHixb|BUSU6JRWK=
OMC-1 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\FUmlEPTB;MD65OlM4OyEQvF2= Mn3YV2FPT0WU
NCI-H2196 Mo[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwOUe3O|ch|ryP M3OxXnNCVkeHUh?=
HAL-01 MoKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvWTWM2OD1yLkm5PFczKM7:TR?= MUPTRW5ITVJ?
NCI-H2107 M{LKe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP0d5c3UUN3ME2xMlAyQDV2IN88US=> NF:zPYlUSU6JRWK=
LB996-RCC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPTTWM2OD1zLkC4NFUyKM7:TR?= M1jCNnNCVkeHUh?=
NCI-H1395 M2LJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK1Om06UUN3ME2xMlExPjdizszN M17LPXNCVkeHUh?=
CHP-126 MoPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTLZ5lKSzVyPUGuNVYyQTlizszN NWrzRYpJW0GQR1XS
NB69 M{[2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G5cmlEPTB;MT6yOlE1QCEQvF2= NHnMdWNUSU6JRWK=
CAS-1 NXPGW25mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfK[nRKSzVyPUGuN|QzOzFizszN M2HBNnNCVkeHUh?=
JVM-3 NWPjRop6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTFwNEe4OVUh|ryP M3f3eXNCVkeHUh?=
DMS-153 M1TaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTjeplKSzVyPUGuOVc3PzRizszN NI\SdGFUSU6JRWK=
SK-MEL-2 NX7Eb5dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoGzTWM2OD1zLkexO|g6KM7:TR?= NXr2eHVCW0GQR1XS
NCI-H1155 MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PGS2lEPTB;MT63N|Y4PiEQvF2= MoniV2FPT0WU
NCI-H1092 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTvTWM2OD1zLke2NVgzKM7:TR?= MoewV2FPT0WU
LU-165 NIf3NJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3rSWdKSzVyPUGuPFY1PzZizszN MnXnV2FPT0WU
HL-60 NIGwfHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPpRmxKSzVyPUGuPVk6ODhizszN MYnTRW5ITVJ?
REH NFe1UolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[w[G9zUUN3ME2yMlAxPTh{IN88US=> NVPjWow3W0GQR1XS
JVM-2 NH;OSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\0dYFRUUN3ME2yMlA3OTN3IN88US=> M4nHUnNCVkeHUh?=
MN-60 M2DPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjm[|VKSzVyPUKuNVc{ODhizszN MXvTRW5ITVJ?
SCC-15 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzMTWM2OD1{LkKwNlch|ryP NHXZS2RUSU6JRWK=
SNU-C1 NID5TWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\DNYZQUUN3ME2yMlIyOzR|IN88US=> MYXTRW5ITVJ?
SK-MEL-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Lq[2lEPTB;Mj6zNlA1PyEQvF2= M3qyR3NCVkeHUh?=
TGW NWe0OpgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTJwM{WwNlch|ryP M4LUOnNCVkeHUh?=
CA46 NYjaRYZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJwN{W5Olch|ryP MWfTRW5ITVJ?
NCI-H23 MnyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTJwOEC3PVEh|ryP NUTUVXpuW0GQR1XS
MMAC-SF MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXlbG9KSzVyPUKuPFY3OjhizszN NGTHU4dUSU6JRWK=
NCI-H2171 NUfCfVdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HtUGlEPTB;Mz6wN|Q1QCEQvF2= MnixV2FPT0WU
A704 Mke2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTNwMUSxPVQh|ryP M2Pmb3NCVkeHUh?=
DB NV75XXoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrXTWM2OD1|LkK1OVc3KM7:TR?= MWjTRW5ITVJ?
NCI-H719 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PYR2lEPTB;Mz6zNFM5PCEQvF2= NV7NWoFsW0GQR1XS
MC-CAR M{TnN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrrNFcxUUN3ME2zMlU1QDF5IN88US=> NHPuNoRUSU6JRWK=
SIMA M3;tXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i0NGlEPTB;Mz61PFQyPiEQvF2= NVi3RopSW0GQR1XS
SW872 M1;hbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW2SHE3UUN3ME2zMlc5OTBzIN88US=> MXjTRW5ITVJ?
HCC1187 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vmeWlEPTB;Mz63PFMyPSEQvF2= MoK1V2FPT0WU
EW-13 NXrLTo9mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTNwOEO0NVch|ryP NULmO4RpW0GQR1XS
NCI-SNU-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ftNGlEPTB;ND6yNVk6QSEQvF2= NWLyOHJ3W0GQR1XS
NCI-H226 NYjyeY9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTRwM{O2NFYh|ryP NEf1emZUSU6JRWK=
RPMI-8866 NYHiflFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X4c2lEPTB;ND6zOlAzQSEQvF2= NW\nbXBzW0GQR1XS
OCI-AML2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfUXmxKSzVyPUSuOVUzOyEQvF2= M4DBeHNCVkeHUh?=
LU-65 M4LGPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTz[3lKSzVyPUSuPVMxOzNizszN NHPWT5RUSU6JRWK=
SK-N-DZ MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P5NmlEPTB;NT62N|Q3PSEQvF2= MXrTRW5ITVJ?
NB14 NHnXNI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHNTWM2OD13Lkm3NVM2KM7:TR?= NGrFeYpUSU6JRWK=
COLO-829 NVXFZWpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW5VoRKSzVyPU[uN|M{PTlizszN M{OydnNCVkeHUh?=
MHH-CALL-2 NVfn[mNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DtR2lEPTB;Nj61NVUxQCEQvF2= NVi4blhkW0GQR1XS
NCI-H1770 NI\rPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\KNYVKSzVyPU[uOlY6ODRizszN NHjk[|JUSU6JRWK=
ECC4 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2niNGlEPTB;Nj64NlE4QSEQvF2= NYTOZ5pRW0GQR1XS
A498 NEe5WWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTZwOEexPVIh|ryP M3zsRXNCVkeHUh?=
DMS-79 NFX5emJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTdwMES1NVIh|ryP Ml71V2FPT0WU
P30-OHK NH3oc41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTdwMkG5NFYh|ryP MX;TRW5ITVJ?
D-502MG M3\hZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHibWxiUUN3ME23Mlk5OzZizszN MonFV2FPT0WU
RCC10RGB NVPFU|ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTQU2lKSzVyPUiuNFYzQCEQvF2= M3uxTHNCVkeHUh?=
U-698-M MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnX[HVKSzVyPUiuNlkzOjZizszN NXv2RXJTW0GQR1XS
BB49-HNC M{PFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rvRmlEPTB;OT60NlI3PSEQvF2= NVrMUYE2W0GQR1XS
ES1 NVy1c5FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3juVWlEPTB;OT62PFk2PiEQvF2= MYjTRW5ITVJ?
MFM-223 M2HHbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTFyLkm5Nlch|ryP M3j0c3NCVkeHUh?=
C2BBe1 M37Fb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTFzLkO1NlMh|ryP MWDTRW5ITVJ?
EB2 NV7rZmJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH0TWM2OD1zMj62PFgyKM7:TR?= MnLPV2FPT0WU
C8166 M3jwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTF|LkizNFMh|ryP NXvtdnI{W0GQR1XS
ES3 NV\Ye|VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f5SWlEPTB;MUOuPVk4PyEQvF2= MU\TRW5ITVJ?
NCI-H1650 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ixT2lEPTB;MU[uN|c3PSEQvF2= NVywV|dDW0GQR1XS
Mo-T M1q0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnwTWM2OD1zNz60NFI6KM7:TR?= MoP3V2FPT0WU
NB7 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED1e|FKSzVyPUG3Mlc1PjdizszN NVzydYFrW0GQR1XS
ES7 NHj1T4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nyfGlEPTB;MUmuOVUxPyEQvF2= M3\FPXNCVkeHUh?=
ES5 M2[zcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzmTWM2OD1{MT63OlcyKM7:TR?= MnXDV2FPT0WU
MSTO-211H NHrOUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPUTWM2OD1{MT64PFU5KM7:TR?= MWjTRW5ITVJ?
U-87-MG M{PiRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz5TFhwUUN3ME2yOU4yQTZ4IN88US=> NXnNcIx{W0GQR1XS
THP-1 NHG3eZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XPcGlEPTB;MkmuO|IxOSEQvF2= M{XiN3NCVkeHUh?=
NB10 MoHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13TW2lEPTB;M{CuNlY6PCEQvF2= NHLRUW9USU6JRWK=
NH-12 NGjyXpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH4TWM2OD1|Mz6yNFE4KM7:TR?= M3XJVHNCVkeHUh?=
COLO-824 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rHbGlEPTB;M{SuNVAxPiEQvF2= MlXvV2FPT0WU
SKM-1 M{fudGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTN5Lki0NlIh|ryP M1HxenNCVkeHUh?=
NCI-H1838 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTN6LkO3PVch|ryP MUDTRW5ITVJ?
RL MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTHTWM2OD1|OT6yOFc4KM7:TR?= NXPyOo9IW0GQR1XS
COLO-800 NYPDRXJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm4cWZqUUN3ME20NE4xPzd|IN88US=> NHL6Z4FUSU6JRWK=
KG-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTRyLki5OVUh|ryP NXSwPGlJW0GQR1XS
TUR NFrv[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjYXI1yUUN3ME20NU43Ozl7IN88US=> MmXyV2FPT0WU
LNCaP-Clone-FGC NXO4NmJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTMTWM2OD12MT65NFE4KM7:TR?= MUjTRW5ITVJ?
NCI-H322M NGnyPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnv[5dVUUN3ME20Nk42QTh2IN88US=> MVXTRW5ITVJ?
LNCaP  NX7h[GdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUi0cVVVUUN3ME25NU4{KG6P MYSyOVUxPTF5NB?=
C4-2 M1fM[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRThibl2= MVWyOVUxPTF5NB?=
JURKAT NF\DfGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYiyOEBp MkHqTWM2OD12MU[uOlYhdk1? NXPCZYJ[OjR3MUm5PVU>
MOLT-4 M2\ncGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzBeIpwOjRiaB?= MmHHTWM2OD1{OEWzMlUhdk1? NEXXcGgzPDVzOUm5OS=>
REH NIDCWIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HDclI1KGh? NYnLVJQ{UUN3ME2yPFcvPjhibl2= M2jnXlI1PTF7OUm1
NALM-6 MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfkNlQhcA>? NInGPJZKSzVyPUO0N|MxKG6P MYKyOFUyQTl7NR?=
RS 4;11 M{nXV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq5NlQhcA>? NEfuSpRKSzVyPUWxPU4xPSCwTR?= MVuyOFUyQTl7NR?=
697 M3XLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTINlQhcA>? NVPvV2Z6UUN3ME2yNVA4NjFibl2= NWXabmxUOjR3MUm5PVU>
SIL-ALL NXXkOpF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[yOEBp MoTDTWM2OD1zOUmuO|chdk1? NFr4XpAzPDVzOUm5OS=>
CEM M4PjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;FcVI1KGh? MYnJR|UxRTV{LkG4JI5O MlTSNlQ2OTl7OUW=
P12 NGLpc2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfObHAzPCCq NYDZW2h2UUN3ME2zPU4zPyCwTR?= NH;qW5czPDVzOUm5OS=>
NALM-16 NGjNfnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2q5RVI1KGh? NUTxNldJUUN3ME25Ok4zQCCwTR?= NG\MVWkzPDVzOUm5OS=>
JURKAT NXS3W2VFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HDeFQ5KGh? M{\wR2lEPTB;MUSuPFQhdk1? NVPUdoo3OjR3MUm5PVU>
MOLT-4 NUXOfXY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPSOFghcA>? M2ftemlEPTB;Mk[uOkBvVQ>? Ml7lNlQ2OTl7OUW=
REH Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3sOFghcA>? MWnJR|UxRTR2LkexJI5O M4Lue|I1PTF7OUm1
NALM-6 M17CdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPoOFghcA>? Mnj5TWM2OD1{Mz6yOkBvVQ>? NVnxUG5LOjR3MUm5PVU>
RS 4;11 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;rOFghcA>? NVz3d5JJUUN3ME2xOlQvOjhibl2= MUOyOFUyQTl7NR?=
697 NULtXZZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLOfHI1QCCq MV;JR|UxRTNyNT6zJI5O NEfPPVczPDVzOUm5OS=>
SIL-ALL NUn0dVlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDoOFghcA>? MXvJR|UxRTd2Lk[yJI5O MnS5NlQ2OTl7OUW=
CEM M1v1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXe0PEBp NG\pU2hKSzVyPUK0MlU2KG6P NUT4e4hSOjR3MUm5PVU>
P12 NHHSSohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUi0PEBp MVfJR|UxRTF6LkS2JI5O NGnkdoUzPDVzOUm5OS=>
NALM-16 MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\lOFghcA>? MXHJR|UxRTZ|LkK0JI5O MWSyOFUyQTl7NR?=
JURKAT NVLZdm97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjBO|IhcA>? M3Xhb2lEPTB;Mz62OUBvVQ>? M4LMfVI1PTF7OUm1
MOLT-4 M3T0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrCd5M4OiCq M2HXVGlEPTB;Nz6zPUBvVQ>? NHTMZVMzPDVzOUm5OS=>
REH NIn1bpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjBc2NCPzJiaB?= Mm\QTWM2OD1zNj6wNUBvVQ>? NXfSO2k2OjR3MUm5PVU>
NALM-6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkewO|IhcA>? Mke2TWM2OD1zLke4JI5O Mor0NlQ2OTl7OUW=
RS 4;11 MofsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\pXFVGPzJiaB?= MWfJR|UxRTRwM{igcm0> MnOxNlQ2OTl7OUW=
697 NWXlOZVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\VNHA4OiCq M1jsZWlEPTB;N{SuNlghdk1? MV:yOFUyQTl7NR?=
SIL-ALL NFzJbHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoiyO|IhcA>? MoHnTWM2OD15LkKgcm0> NXG0dJJZOjR3MUm5PVU>
CEM MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXm3NkBp MoLoTWM2OD13LkSyJI5O NFvscFEzPDVzOUm5OS=>
P12 MnzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfFO|IhcA>? MYTJR|UxRTZwM{egcm0> Mn3ENlQ2OTl7OUW=
NALM-16 MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYW3NkBp MVTJR|UxRTd5LkezJI5O NILJbGwzPDVzOUm5OS=>
Y79 M4j4UGFxd3C2b4Ppd{BCe3OjeR?= NH\rXG8yNTVyIH7N NUDiXJdQOTJxMkSgbC=> NH22VoVFVVOR NHjxZ3lqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ> NGfwV|YzPDN4Nk[2OS=>
WER-Rb-1 NX;4T3FLSXCxcITvd4l{KEG|c3H5 Ml;JNU02OCCwTR?= M3nTPFEzNzJ2IHi= M2DEd2ROW09? MmD5bY5lfWOnZDDhdI9xfG:|aYOge4hq[2hiY3HuJIJmKGWwaHHuZ4VlKGK7IFjU MlfhNlQ{PjZ4NkW=
G7 NVXSR49ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTNwMzDuUS=> M1rVTFI1OjB2N{Oz
G166 NIDvSm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTdwMDDuUS=> MVeyOFIxPDd|Mx?=
CB660 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XvW2lEPTB;Nj60JI5O MUCyOFIxPDd|Mx?=
CB1117 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\ObWlEPTB;MUWuOkBvVQ>? NXLle|NwOjR{MES3N|M>
KB-3-1 NXn0W2RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jlbmlEPTB;MT60PEDDuSByLkWzJI5O M1r2XFI{QTZ{NES1
KB-8-5-11 MkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTVwMEGgxtEhOi5yMTDuUS=> M4i1XFI{QTZ{NES1
KB-C-1 Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHoTWM2OD1zNj63OkDDuSB2LkWxJI5O M4e1UFI{QTZ{NES1
KB-V-1 NYH2RpVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJ6MT6yOEDDuSB|MT61O{BvVQ>? NV[5OFY4OjN7NkK0OFU>
OVCAR-8 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\3UmtyUUN3ME23MlE6KMLzIEOuOlAhdk1? MmTJNlM6PjJ2NEW=
NCI-ADR-RES MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\ubG9KSzVyPUGyO|MvOzBiwsGgNVkyNjJyIH7N NGTUfWUzOzl4MkS0OS=>
MCF7 NI\FWJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPjTWM2OD13LkGxJOKyKDFwNEegcm0> M3PwTVI{QTZ{NES1
MCF7-FLV1000 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrwWXd6UUN3ME2zPVMvOThiwsGgO|QvQDNibl2= NVnTS3J1OjN7NkK0OFU>
S1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPabJBKSzVyPUK0MlMxKMLzIESuO|Uhdk1? NF3ZOI0zOzl4MkS0OS=>
S1-M1-80 NHLMfWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoiwTWM2OD1{NkGuNFYhyrFiNEiuNlUhdk1? NGnNTGwzOzl4MkS0OS=>
CORL-23/P MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrqfI9KSzVyPUSuN|ghyrFiMT6yOUBvVQ>? NHq1cGszOzl4MkS0OS=>
CORL-23/R M3Hac2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnLTWM2OD13LkG2JOKyKDFwOEOgcm0> NVvhNoRsOjN7NkK0OFU>
NIH3T3 M{\5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTRyLk[wJOKyKDRwOUegcm0> M3y1TFI{QTZ{NES1
NIH3T3-G185 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[zZ5JSUUN3ME2yOFE{NjRyINMxJFQzOy54NjDuUS=> MV:yN|k3OjR2NR?=
pcDNA-HEK293 NVXIfHp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJwN{WgxtEhOC54NzDuUS=> NFTqVJEzOzl4MkS0OS=>
MDR19-HEK293 NVvIT2dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M36ybGlEPTB;OEWuOVAhyrFiMUOuOlchdk1? MnnzNlM6PjJ2NEW=
R482-HEK293 M1\JSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfWTWM2OD1{NT65O{DDuSB2Lkm1JI5O M1PneVI{QTZ{NES1
MRP1-HEK293 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEWwcphKSzVyPUKuPVkhyrFiMT60PUBvVQ>? MXuyN|k3OjR2NR?=
SF188 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X3UlExNTFyMDDuUS=> M3m3[|I1NTl4IHi= NEXZ[FhFVVOR NUjHeo5xcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lMUBidmRiY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy NXyx[3hxOjN6OEe2OFU>
T98G MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXqxNE0yODBibl2= M1nlbVI1NTl4IHi= NH3l[GZFVVOR NEex[I5qdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDjc45k\W62cnH0bY9vNSCmZYDl[IVvfCCvYX7u[ZI> NE\Zb4QzOzh6N{[0OS=>
DU145 NH;BPFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HtRWROW09? MnGyTWM2OOLKvE[wJI5O NIjueXUzOzh6NESyPC=>
LNCaP  NF;4TotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHEUXNQ M17rW2lEPTEkiMy3OUBvVQ>? MljJNlM5QDR2Mki=
PC3 M1zEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXhRoVnTE2VTx?= NFS2W4tKSzVy4pk8NVc2KG6P MWSyN|g5PDR{OB?=
RT4 MkLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU[w[Wt1UUN3ME2yO{4zOSCwTR?= NGLt[WczOzd7Mk[zPS=>
5637 NX;zN5ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTR3LkS3JI5O NH\YR4czOzd7Mk[zPS=>
T24 NH7KTWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjuTWM2OD15OT6xNkBvVQ>? M3[0T|I{Pzl{NkO5
MCF7  MUjGeY5kfGmxbjDBd5NigQ>? Moq0NVAxKG6P NX;DeIpSOSCq NIO0cnpFVVOR NUX1dGZZemWmdXPld{B1cGViaX7keYN1cW:wIH;mxsBIemWkMT|CpHNoczFuwrDQd|ItyqCVZYLwbY5iOyxiYX7kxsBYcXOyMh?= MmjwNlM4PzB{NES=
KB-V1  M1LxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHqTWM2OD1|LkmyJO69VQ>? NUHQfnNNOjN3OUOxPVY>
Hec50co M1ThRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPNfYxKSzVyPUWgcm0> M2D0ZlI{OTR4Nki3
MDA-MB-468 NHno[o9CeG:ydH;zbZMhSXO|YYm= M{e2dVEwPS9zMDDuUS=> NXr6dG9oOjRxNEivO|IhcA>? NW\CWmlHTE2VTx?= M2LTXolv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MX[yN|E1PDJ7NB?=
MCF10A NELrZ5NCeG:ydH;zbZMhSXO|YYm= M{TNUFEwPS9zMDDuUS=> M2[yOVI1NzR6L{eyJIg> MofuSG1UVw>? MXHpcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M3jETlI{OTR2Mkm0
Huh-7 NG\mNVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT3ZpVzOS9zMD:xNFAwOTByMDDuUS=> MVS0PEBp MX3k[YNz\WG|ZYOgeIhmKGOnbHygeoli[mmuaYT5JIRwe2VvZHXw[Y5l\W62bIm= MVSyNlc1PTV6Nx?=
Daoy  MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fr[FEvQDd3LUK0NEBvVQ>? M33QbFczKGh? NVj3R|lPTE2VTx?= M4PpV2lEPTB;NTDuUS=> MmGxNlI{QTB{N{m=
ONS-76 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVexMlg4PS1{NECgcm0> MYK3NkBp MXXEUXNQ NY\vc3BkUUN3ME23MlUhdk1? NFK2ZpozOjN7MEK3PS=>
SUM 149 NGW3[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ewWVAuOTByIH7N NWLhOXh4PzJiaB?= MX\pcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= NH7XZ2YzOjNyOUmzPS=>
MDA-MB-231 NHzvV45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrwd4hMOC1zMECgcm0> MXq3NkBp NWn5NXBEcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz M1iyS|IzOzB7OUO5
HR5 M3OycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7kPYVwOC1zMECgcm0> MVy3NkBp Ml\IbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy M2LFXFIzOzB7OUO5
BT-474-M1 NYfXNYNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXewMVExOCCwTR?= Mke1O|IhcA>? NGPafGlqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> MY[yNlMxQTl|OR?=
AU565 NEn1V|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jDVFAuOTByIH7N M3zQfVczKGh? NXnsSJpkcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz MWKyNlMxQTl|OR?=
T47D MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfkdow4OC1zMECgcm0> NVPMOIhxPzJiaB?= NInrdG9qdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> M1jFPFIzOzB7OUO5
MCF7 MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PFO|AuOTByIH7N NHT5d2c4OiCq NVzHZoVLcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz MWSyNlMxQTl|OR?=
HCT116p53(+/+) NUnkVpNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPSNHlzOTBvMUCwNEBvVQ>? MYKyOE81QCCq MnT0bY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJINwdXCuZYTlcJkh[XRiMkWgcm0> NIHtfGQzOjJ4MkG3NS=>
HCT116p53(-/-) M4jIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPlUHZqOTBvMUCwNEBvVQ>? NUW4[JFFOjRxNEigbC=> MlqxbY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJINwdXCuZYTlcJkh[XRiMkWgcm0> NGLMZ5ozOjJ4MkG3NS=>
HeLa  M3j5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXKV20yOC1zMECgcm0> MmPIOFghcA>? NV2zPI92TE2VTx?= NVKwW|JGUUN3ME21Nk46KG6P MX6yNlA5ODJ|NR?=
HeLa  NHnsdGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzWUYcyOC1zMECgcm0> NF7uXVY4OiCq NXL2RmJ4TE2VTx?= MnzZTWM2OD13MD61JI5O NGmxT5AzOjB6MEKzOS=>
GBC MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[3NkBp MYHJR|UxRTF2Lke4JI5O M3;rdVIyQTZ3N{O5
GB-CL-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjYO|IhcA>? NX7WNlJ{UUN3ME21MlIzKG6P NVHVXnhYOjF7NkW3N|k>
Mz-ChA-2 MkfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVK3NkBp M1nFbmlEPTB;Mz6zNUBvVQ>? MoGxNlE6PjV5M{m=
TGBC1-TKB Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTzNVQ1KGh? NUfpSZhiUUN3ME22MlczKG6P MXKyNVk3PTd|OR?=
Wittier NXfKZYZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT0Zm1ZPzJiaB?= M3HuXWlEPTB;Mz6yOkBvVQ>? M4[3V|IyQTZ3N{O5
H-1 NXHSXYhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjER|VLPzJiaB?= MV\JR|UxRTlwNUSgcm0> Mo[wNlE6PjV5M{m=
HuH-28 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X4XFczKGh? NUPCOWdkUUN3ME2xNU4yQSCwTR?= MnT1NlE6PjV5M{m=
NEC NFvv[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWC3NkBp NFr5SmZKSzVyPUmuPVghdk1? MV:yNVk3PTd|OR?=
REB NXTnW2p5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfKTXNKPzJiaB?= M1joNmlEPTB;MUOuOVEhdk1? MkPMNlE6PjV5M{m=
CC-LP-1 NIPrclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K5UlczKGh? MV;JR|UxRTVwOESgcm0> NUPDcWtPOjF7NkW3N|k>
CC-SW-1 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjxZm04OiCq M1HiNGlEPTB;OT61OUBvVQ>? NYHPXJVVOjF7NkW3N|k>
EGI-1 M4LHNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfrRXlFPzJiaB?= MmPXTWM2OD1zMD63NkBvVQ>? M2TiWFIyQTZ3N{O5
Sk-ChA-1 MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HWc|czKGh? MVrJR|UxRTF5LkKgcm0> NEDC[o4zOTl4NUezPS=>
TFK-1 MoHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUe3NkBp MWjJR|UxRTF|LkS1JI5O NVyxWXlvOjF7NkW3N|k>
786-O NYjFSWxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:2fmQ2NThyIH7N MlzHPVYhcA>? MVrIR4w> M1e2fpN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= NVrHSoM2OjF4NEKzO|Q>
A498 M1rV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrG[Hg2NThyIH7N NHrI[oo6PiCq MVvIR4w> Ml7zd5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P M4DaNVIyPjR{M{e0
ACHN MnTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPEOU05OCCwTR?= NY\aWYNoQTZiaB?= NInmSItJS2x? M1rxZZN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= MYmyNVY1OjN5NB?=
Caki-1 M{m3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWezR2Q{PS16MDDuUS=> NFTKd4g6PiCq MXXIR4w> MYLzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? MViyNVY1OjN5NB?=
SN12C MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTNUVg2NThyIH7N NFW5T|U6PiCq MXTIR4w> M1XoVpN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= NWfRe3ZZOjF4NEKzO|Q>
HMC-1.1 NG\SSI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGH3RXUyNTFyMECgcm0> NWP5SFk1PzJiaB?= NFfhcm5qdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? M1:1VlIyOjR{MUi5
HMC-1.2 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\3NU0yODByIH7N MV63NkBp NXrjcJk4cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n NIPWbXczOTJ2MkG4PS=>
C2 MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX2xMVExODBibl2= MWq3NkBp MYLpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> NXLWVWRLOjF{NEKxPFk>
CHP-212 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXmxMVEzPSCwTR?= MXKyOE0yOjBiaB?= MmK2bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MlnDNlEyPjl{NEK=
IMR-32 MoXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LGTlEuOTJ3IH7N MV:yOE0yOjBiaB?= NFHacJJqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MYGyNVE3QTJ2Mh?=
Kelly MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoeyNU0yOjVibl2= M1XObVI1NTF{MDDo NUK2Vo5ycW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NFS4R5YzOTF4OUK0Ni=>
SH-EP NHrJeFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjNeldyOS1zMkWgcm0> MoDWNlQuOTJyIHi= NHzmUYxqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l M1;CWVIyOTZ7MkSy
SH-SY5Y NX\CV5hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXFNU0yOjVibl2= MoHNNlQuOTJyIHi= NU\reJVYcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NHjFWHkzOTF4OUK0Ni=>
SK-N-AS MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe4WXgyNTF{NTDuUS=> M1nqN|I1NTF{MDDo MX3pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MlnnNlEyPjl{NEK=
SK-N-BE MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;SeVEuOTJ3IH7N M1P4VlI1NTF{MDDo MYjpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n Mm\sNlEyPjl{NEK=
KG1 MnPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rXdVEwOTBxMUCwJI5O MnLDO|IhcA>? MmXaSG1UVw>? NIP1NJlqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NEX2W5oyQTR3OEO1PC=>
U937 M2CyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnEdHpTOS9zMD:xNFAhdk1? M3vEb|czKGh? Mli4SG1UVw>? MWXpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MYixPVQ2QDN3OB?=
CAL62 NV71XmVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nPelAvOS1zMECgcm0> MUG3NkBp MoG4SG1UVw>? MnTNSWM2OD1zLkSgcm0> NVK3W5BTOTl{MkO1OVM>
OCUT-1 NYm1XoNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCwTVNROC5zLUGwNEBvVQ>? NWrWTYVzPzJiaB?= MXfEUXNQ NUT1OoxITUN3ME2yMlMhdk1? NEjrWYUyQTJ{M{W1Ny=>
8505C M2LyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYmwMlEuOTByIH7N MVu3NkBp M364VmROW09? MXLFR|UxRTNwMjDuUS=> NITySngyQTJ{M{W1Ny=>
ACT-1 MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX3Wm9kOC5zLUGwNEBvVQ>? MWK3NkBp MnHlSG1UVw>? NFLtUYFGSzVyPUWuOEBvVQ>? M1e3WFE6OjJ|NUWz
SW1736 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH4OlcxNjFvMUCwJI5O Mo\yO|IhcA>? M176VWROW09? MoLsSWM2OD13Lk[gcm0> M2PYSlE6OjJ|NUWz

... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 21 mg/mL (40.25 mM)
エタノール 100 mg/mL (191.69 mM)
<1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

カスタマーフィードバック (10)


Click to enlarge
Rating
Source Cancer Cell , 2010, 18, 641–654. BI 2536 purchased from Selleck
Method Immunohistochemical analysis
Cell Lines SCID mice
Concentrations
Incubation Time
Results Control tumors grow exponentially, whereas genetic ablation of Cdc20 results in complete tumor regression in about 10 days. In comparison, treatment with taxol, vincristine, and BI2536 only induces partial responses ( Figure C). In agreement with the data observed in vitro, immunohistochemical analysis of samples taken 3 days after the first treatment indicates lack of proliferation (as measured by BrdU incorporation) and massive apoptosis in Cdc20 null cells, whereas all other samples maintain significant levels of proliferation and reduced apoptotic markers ( Figure D)

Click to enlarge
Rating
Source Nat Cell Biol, 2011, 13, 1265-71. BI 2536 purchased from Selleck
Method cold-stable assay, Immunological methods
Cell Lines RPE1 cells
Concentrations 40 nM
Incubation Time 45 min
Results To examine whether B56-PP2A attenuates the signalling of kinetochore kinases other than Aurora B, we examined Plk1. Remarkably, wash-in of the Plk1 inhibitor BI2536 also restored K-fibres in B56-PP2A-siRNA cells.

Click to enlarge
Rating
Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Western blot
Cell Lines NB TICs
Concentrations 10-100 nM
Incubation Time 16/24 h
Results The cyclin-dependent kinase inhibitor p21, a newly identified substrate of PLK1, also accumulated in BI 2536-treated NB TICs (Fig. C). Finally, PLK1 kinase activity was inhibited following treatment of NB TICs with BI 2536, as demonstrated by anti-PLK1 immunoprecipitiation followed by in vitro PLK1 kinase assay ( Fig. D)

Click to enlarge
Rating
Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Trypan blue exclusion, Western blot
Cell Lines NB TICs
Concentrations 10/30/100 nmol/L
Incubation Time 24/48/72 h
Results We observed a significant difference in viable cell numbers in BI2536-treated samples, as compared with DMSO (vehicle)-treated cells, at 24 hours posttreatment. The difference became more pronounced with time, such that at 72 hours there were only approximately 20% viable cells following treatment with 10 nmol/L BI 2536 and approximately 2% to 5% viable cells following treatment with 30 and 100 nmol/L as compared with DMSO-treated cells(Fig. A). At 24 hours, BI 2536-treated cells gradually accumulated cleaved PARP, in contrast to DMSO-treated cells, suggesting induction of apoptosis ( Fig. B).

Click to enlarge
Rating
Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5-25 mg/kg
Incubation Time 0-24 d
Results As shown in Figure A,tumor growth was significantly inhibited following administration of the third cycle of BI 2536 therapy. When mice were administered 25 mg/ kg weekly on 2 consecutive days for a total of only 2 cycles, tumor growth was inhibited after the second cycle ( Fig. B)

Click to enlarge
Rating
Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5 mg/kg
Incubation Time 0-60 d
Results We examined a combination of a low dose of BI 2536 (12.5 mg/kg) with a low dose of irinotecan (10 mg/kg), a topoisomerase inhibitor with demonstrated activity in phase II clinical trials in relapsed NB. Single-agent treatment with low-dose of either BI 2536 or irinotecan was comparably efficacious, resulting in significant growth inhibition, as compared with vehicle-treated animals.

Click to enlarge
Rating
Source J Invest Dermatol, 2011, 131, 1886–1895. BI 2536 purchased from Selleck
Method MTT assay
Cell Lines M14 cell lines, WM-115 cell lines
Concentrations 1-20 nM
Incubation Time
Results Specific inhibition of Plk-1 using the commercially available inhibitor BI 2536 led to a dose- and time-dependent decrease in human melanoma cell viability.

Click to enlarge
Rating
Source J Biol Chem, 2012, 287(21), 17088-99. BI 2536 purchased from Selleck
Method Cell death assay
Cell Lines HeLa cells
Concentrations 0 -120 nM
Incubation Time 72 h
Results In HeLa cells lacking GRK5, there was an~4.5-fold decrease in the EC50 of BI 2536-mediated cell death (control shRNA, 18.9 ?.2 nM; GRK5 shRNA, 4.1?.1 nM, n = 6, p < 0.05) (Fig. A). Similar to BI 2536, cells lacking GRK5 were ~4.5-fold more sensitive to GSK461364 compared with control cells (EC50 for control shRNA cells, 17.0 ?4.4 nM;EC50 for GRK5-shRNA cells, 3.8 ?0.7 nM, n = 4, p < 0.05).

Click to enlarge
Rating
Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 0-10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

Click to enlarge
Rating
Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

文献中の引用 (50)

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related PLK 阻害剤

  • SBE 13 HCl

    SBE 13 HCl is a potent and selective PLK1 inhibitor with IC50 of 200 pM, >4000-fold selectivity over Aurora A kinase, Plk2 and Plk3.

  • Ro-3306

    RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with Ki of 20 nM, >15-fold selectivity against a diverse panel of human kinases.

  • CCG-1423

    CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.

  • ML141

    ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.

  • Rigosertib (ON-01910)

    Rigosertib (ON-01910)はどんな作用にPoloキナーゼ(PLK1)の非ATP競争性阻害剤、IC50が9nMになる。

  • HMN-214

    HMN-214はポロのようなキナーゼ(Plk)1への経口で強力な阻害剤で、IC50が118 nMになる。

  • GSK461364

    GSK461364はチオフェンアミド、PLK1酵素の阻害で、Kiが2 nM。[1]

    Features:Demonstrates >390-fold selectivity for Plk1 relative to Plk2 and Plk3.

  • Volasertib (BI 6727)

    Volasertib (BI 6727)は、0.87nMのIC50による非常に強力なポロのようなキナーゼ1(Plk1)阻害剤です。

    Features:A high volume of distribution, indicating good tissue penetration, and a long terminal half-life.

  • MLN0905

    MLN0905は有効的なPLK1阻害剤で、IC50が2 nMです。

最近チェックしたアイテム

Tags: BI 2536を買う | BI 2536供給者 | BI 2536を購入する | BI 2536費用 | BI 2536生産者 | オーダーBI 2536 | BI 2536代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ