BI 2536 化学構造
分子量: 521.66

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製品説明

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  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 NH\rO2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz5U3I5UUN3ME2wMlAxPzd4IN88US=> M4SzZXNCVkeHUh?=
ACN NFXzXWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELnXndKSzVyPUCuNFA5PDNizszN NFTaWY9USU6JRWK=
TE-8 NVu1UIxXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWKxUGZ6UUN3ME2wMlAxQTRzIN88US=> M1y4fHNCVkeHUh?=
LC-2-ad NVPVZVJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPFTWM2OD1yLkCxNFk{KM7:TR?= MkTWV2FPT0WU
ALL-PO NWPmeldvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\JTWM2OD1yLkCxN{DPxE1? NEnvcFBUSU6JRWK=
EW-16 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEGzN|Yh|ryP M1HyfnNCVkeHUh?=
KM12 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXFTWM2OD1yLkCxN|Q5KM7:TR?= NH3WeXZUSU6JRWK=
GI-1 NIPoXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3vPGlKSzVyPUCuNFE{QDNizszN NFywcoJUSU6JRWK=
LS-411N NET1ZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XpWmlEPTB;MD6wNVQxPyEQvF2= MV\TRW5ITVJ?
ES8 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEG0PVQh|ryP MXHTRW5ITVJ?
SNU-C2B M2D4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEG1NlYh|ryP NVroZmZHW0GQR1XS
CESS M2PpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEG2NFIh|ryP MY\TRW5ITVJ?
697 MnS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLyTWM2OD1yLkCxOlY5KM7:TR?= MXnTRW5ITVJ?
NCI-H1963 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf1TnJPUUN3ME2wMlAyPjd|IN88US=> MWnTRW5ITVJ?
IA-LM NIXt[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEG2PFgh|ryP NWjkNm92W0GQR1XS
SW954 MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1iwTGlEPTB;MD6wNVcxPSEQvF2= MVrTRW5ITVJ?
RL95-2 NI\pboxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vR[2lEPTB;MD6wNVc{QCEQvF2= NVyxeVZMW0GQR1XS
LXF-289 M3HHW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i3UGlEPTB;MD6wNVc4KM7:TR?= M{O1XXNCVkeHUh?=
OCUB-M MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;4NGlEPTB;MD6wNVgzPiEQvF2= NV3TOppbW0GQR1XS
RKO M3zXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\LepZJUUN3ME2wMlAyQTh5IN88US=> NG[weWZUSU6JRWK=
LOUCY MlfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rXN2lEPTB;MD6wNlA2KM7:TR?= M2HVOXNCVkeHUh?=
NOS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTJ[ZdKSzVyPUCuNFIxQTNizszN MkPMV2FPT0WU
A4-Fuk NILhPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jwNWlEPTB;MD6wNlIyQCEQvF2= M1HxRnNCVkeHUh?=
A388 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMEKyNlch|ryP M1zt[nNCVkeHUh?=
TE-9 M4XN[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEKyOlEh|ryP M4rsfXNCVkeHUh?=
KURAMOCHI M2q0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnnSXNKSzVyPUCuNFIzQDVizszN NUXHdXNXW0GQR1XS
KALS-1 MmrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPhTWM2OD1yLkCyN|M5KM7:TR?= MkjIV2FPT0WU
HOP-62 NX7TVWc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK2TWM2OD1yLkCyOFIh|ryP MlHyV2FPT0WU
RPMI-8402 Mle1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LHcGlEPTB;MD6wNlUxQCEQvF2= NXX6PGg4W0GQR1XS
TE-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjZdotwUUN3ME2wMlAzPTF{IN88US=> M2OxNHNCVkeHUh?=
CCRF-CEM NXfrdJBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEK1OFMh|ryP MmDWV2FPT0WU
HUTU-80 NHjveJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mni1TWM2OD1yLkCyOlI1KM7:TR?= MUTTRW5ITVJ?
NCI-H1648 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPUVoNKSzVyPUCuNFI3PDdizszN MVLTRW5ITVJ?
HCE-4 MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzGSZRKSzVyPUCuNFI3QDJizszN M1r3[XNCVkeHUh?=
ETK-1 MnS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDGeYNKSzVyPUCuNFI4OzZizszN MnLCV2FPT0WU
TE-15 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnhTWM2OD1yLkCyO|M5KM7:TR?= MlLvV2FPT0WU
BE-13 Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUC4N4tMUUN3ME2wMlAzPzRizszN M3n5NXNCVkeHUh?=
KE-37 MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS1TWM2OD1yLkCyO|QyKM7:TR?= MnjsV2FPT0WU
NCI-H1355 Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEKyUZBKSzVyPUCuNFI4QDNizszN NFXOc3RUSU6JRWK=
TE-11 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUSwV|lbUUN3ME2wMlAzQDB7IN88US=> NVW0dHd4W0GQR1XS
BL-70 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv4TWM2OD1yLkCyPFU4KM7:TR?= MljHV2FPT0WU
ES6 M{Tld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMEK4PFEh|ryP Ml\5V2FPT0WU
GT3TKB MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW2TWM2OD1yLkCyPVU{KM7:TR?= M3PjS3NCVkeHUh?=
LB647-SCLC NIDWcYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMEOxPVUh|ryP MlzrV2FPT0WU
NB13 NIjMfGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPROJQzUUN3ME2wMlA{OzF4IN88US=> NIj5d4dUSU6JRWK=
ST486 MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHWNnZYUUN3ME2wMlA{OzN5IN88US=> NEDxNVBUSU6JRWK=
NCI-H82 NVHkW3pvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TsRWlEPTB;MD6wN|M1OyEQvF2= MoC0V2FPT0WU
NTERA-S-cl-D1 NGe4NHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP5[GVKSzVyPUCuNFM{QTlizszN MWjTRW5ITVJ?
ES4 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEO0OlMh|ryP NHfZeWRUSU6JRWK=
SK-NEP-1 NGfPRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEO0PVkh|ryP MYXTRW5ITVJ?
Becker MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEO1OVUh|ryP MoCxV2FPT0WU
A101D NVPjXXdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMEO3OFgh|ryP NGXVbopUSU6JRWK=
SK-UT-1 NIH2WIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEO3O|Qh|ryP MkO0V2FPT0WU
SW982 NHr4WI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTjT29sUUN3ME2wMlA{PzlizszN M13qeHNCVkeHUh?=
TE-10 M1PDRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnZR2FKSzVyPUCuNFQxPDZizszN M4XCfnNCVkeHUh?=
OVCAR-4 MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;OUJNKSzVyPUCuNFQxPTlizszN NXn1VVFyW0GQR1XS
KP-N-YS M2Tsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfUTWM2OD1yLkC0NFg2KM7:TR?= M3mw[3NCVkeHUh?=
BL-41 M4X6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm5TWM2OD1yLkC0NVI2KM7:TR?= MnLvV2FPT0WU
MZ1-PC MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDscG9KSzVyPUCuNFQyOjdizszN MknVV2FPT0WU
PF-382 NIm5Z5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMESxPVgh|ryP NYXOPIxPW0GQR1XS
MOLT-13 M3nIRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1uyN2lEPTB;MD6wOFI{QCEQvF2= NU\vO4Z1W0GQR1XS
HCC1599 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\HSo1mUUN3ME2wMlA1OjV6IN88US=> NXj2c3ZnW0GQR1XS
IST-MEL1 M4DIOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMES0OFIh|ryP NF33VpZUSU6JRWK=
LU-139 NEHQU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLxTWM2OD1yLkC0OFQzKM7:TR?= MXzTRW5ITVJ?
MS-1 M{Padmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXwfndLUUN3ME2wMlA1PzBzIN88US=> NYfDUoY2W0GQR1XS
MFH-ino NU[yc3J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;uPWlEPTB;MD6wOVAxOyEQvF2= MXHTRW5ITVJ?
IMR-5 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEWwNlEh|ryP NULLOlU6W0GQR1XS
TE-5 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHuwSpFKSzVyPUCuNFUxPjNizszN MoSzV2FPT0WU
DJM-1 NIfqU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInWSmhKSzVyPUCuNFUyPDJizszN NGnmR4tUSU6JRWK=
NB17 M3fVT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M360ZmlEPTB;MD6wOVIxPyEQvF2= M{\IR3NCVkeHUh?=
KARPAS-45 NXu2bmtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vrd2lEPTB;MD6wOVM2QCEQvF2= NGP3T3JUSU6JRWK=
TGBC1TKB MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEW0NFUh|ryP MonJV2FPT0WU
ML-2 NF7kTo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDadVRKSzVyPUCuNFU1OTRizszN MVLTRW5ITVJ?
no-10 NYDJOWI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jNdmlEPTB;MD6wOVQ4PCEQvF2= M1;KdHNCVkeHUh?=
CTV-1 NX20eWlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzzPIs2UUN3ME2wMlA2PTB{IN88US=> M{jaXnNCVkeHUh?=
SJSA-1 M3HLfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEW1NkDPxE1? M4TEbXNCVkeHUh?=
HC-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fVeGlEPTB;MD6wOVU6PyEQvF2= MWjTRW5ITVJ?
TE-12 M1PYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEK4enFKSzVyPUCuNFU3OTNizszN MYDTRW5ITVJ?
KY821 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPUTWM2OD1yLkC1OlMzKM7:TR?= NWnZTY84W0GQR1XS
TALL-1 NH;ZSVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3xbopKUUN3ME2wMlA2PzB6IN88US=> NFXhR4ZUSU6JRWK=
DEL MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEW3NFkh|ryP NWPKU5BGW0GQR1XS
TE-6 M{LCbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEW3NlIh|ryP MV;TRW5ITVJ?
SK-LMS-1 M4iwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG1TWM2OD1yLkC1PFA2KM7:TR?= M4XtcnNCVkeHUh?=
EW-1 MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfkdY9KSzVyPUCuNFU5OzdizszN NIjSXmFUSU6JRWK=
8-MG-BA NEHHOWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTKbG5KUUN3ME2wMlA2QDVzIN88US=> NF20b|ZUSU6JRWK=
NALM-6 M{DNOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\sZ2lEPTB;MD6wOVk4OyEQvF2= NGHxZZhUSU6JRWK=
LB771-HNC NFHMUm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfkN|FKSzVyPUCuNFU6PzlizszN M3jwc3NCVkeHUh?=
HT-144 NIq3cplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrZZ3ZKSzVyPUCuNFYyOyEQvF2= NIDNfZhUSU6JRWK=
KM-H2 NFPt[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT4TWM2OD1yLkC2NlIyKM7:TR?= MXrTRW5ITVJ?
SF268 NYD1SoNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvYTWM2OD1yLkC2Nlg3KM7:TR?= NFHufoFUSU6JRWK=
RS4-11 NUO5SHR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXVPFdKSzVyPUCuNFY{ODRizszN NWiyPZJJW0GQR1XS
MHH-PREB-1 M3HiZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwME[zNVkh|ryP NHPoW3JUSU6JRWK=
ATN-1 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vRVWlEPTB;MD6wOlM1PSEQvF2= M4HkTXNCVkeHUh?=
BB30-HNC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3LPZdXUUN3ME2wMlA3PDN4IN88US=> M{jkd3NCVkeHUh?=
CPC-N MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP3SI5KSzVyPUCuNFY2OjRizszN Mn3yV2FPT0WU
NB1 NUDYTIc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwME[2NVMh|ryP Mo\oV2FPT0WU
KS-1 MljNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvtSIlKSzVyPUCuNFY4PDhizszN NV\qe2Y4W0GQR1XS
RXF393 M4DTbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwME[3OlQh|ryP MlPMV2FPT0WU
IST-SL2 NEThNllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTqTWM2OD1yLkC3NFA1KM7:TR?= NGiyU5pUSU6JRWK=
GI-ME-N NF3XfGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXFTWM2OD1yLkC3Nlg3KM7:TR?= NF3BVm9USU6JRWK=
VA-ES-BJ MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHCTWM2OD1yLkC3OFc2KM7:TR?= MnnjV2FPT0WU
NCI-H1581 NHnmVpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPoVpJKSzVyPUCuNFc1PzhizszN NIrvW|JUSU6JRWK=
U-266 MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37GTWlEPTB;MD6wO|Q6PyEQvF2= MkjZV2FPT0WU
DMS-114 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMEe1Nlgh|ryP M3HFV3NCVkeHUh?=
NCI-H187 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSwNWFwUUN3ME2wMlA4PzJ4IN88US=> NFqze|lUSU6JRWK=
SW962 M4XYR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknrTWM2OD1yLkC3PFM6KM7:TR?= MorBV2FPT0WU
MONO-MAC-6 NYPRUFR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;vTWM2OD1yLkC3PVg3KM7:TR?= M4Lp[nNCVkeHUh?=
MOLT-16 MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEixNlEh|ryP MXvTRW5ITVJ?
KNS-42 M3\qRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfY[ZJKUUN3ME2wMlA5OTZzIN88US=> NUXmSXVCW0GQR1XS
CMK NXXIWYpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULzXVJnUUN3ME2wMlA5OjJ3IN88US=> MnroV2FPT0WU
Ramos-2G6-4C10 M1j0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEiyNlUh|ryP MUfTRW5ITVJ?
Daudi M{H6W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjUPVRKSzVyPUCuNFgzPTZizszN NWD4RYE4W0GQR1XS
NCI-H510A MkXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknhTWM2OD1yLkC4N|M3KM7:TR?= NIjB[4ZUSU6JRWK=
LB831-BLC Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLjfVBKSzVyPUCuNFg2PjFizszN NYHifIhNW0GQR1XS
HEL MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\QcWlEPTB;MD6wPFY3QCEQvF2= MUfTRW5ITVJ?
LU-134-A NITGWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Ht[WlEPTB;MD6wPFcxQCEQvF2= MWTTRW5ITVJ?
NCI-H1694 M3;EOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojZTWM2OD1yLkC4O|Q1KM7:TR?= M3\oN3NCVkeHUh?=
KGN MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEi3OVkh|ryP NI[yfYhUSU6JRWK=
A253 NGDCNYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;ZTWM2OD1yLkC4PFIzKM7:TR?= NHvucI9USU6JRWK=
DG-75 MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q1PGlEPTB;MD6wPFkzOiEQvF2= MnvLV2FPT0WU
MOLT-4 M37t[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\nNWlEPTB;MD6wPFk5OyEQvF2= NVvxV5lRW0GQR1XS
NCI-SNU-5 M3nPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEmyOVgh|ryP MmfKV2FPT0WU
ONS-76 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;abnJbUUN3ME2wMlA6Ojd4IN88US=> MXfTRW5ITVJ?
NCI-H446 NV30b5ZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XFdmlEPTB;MD6wPVQ3OiEQvF2= MV;TRW5ITVJ?
COR-L279 NGDLV|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnYUnNQUUN3ME2wMlA6PTV4IN88US=> NH3NNmRUSU6JRWK=
Calu-6 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6zXZlKSzVyPUCuNFk2QThizszN M2T4fXNCVkeHUh?=
BC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMEm2OlIh|ryP NGDVOFlUSU6JRWK=
NCI-H2126 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVezcZBsUUN3ME2wMlA6PzlzIN88US=> NGHkZ5dUSU6JRWK=
NCI-H1882 Ml3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm4bFNKSzVyPUCuNFk5ODlizszN M4LvdHNCVkeHUh?=
BB65-RCC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMUCyPVQh|ryP NFPOcWlUSU6JRWK=
DU-4475 Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvnc2hDUUN3ME2wMlExPDB5IN88US=> NXXFVIVuW0GQR1XS
NCI-H526 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMUC0OEDPxE1? MVnTRW5ITVJ?
NEC8 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMUC1NlUh|ryP MWPTRW5ITVJ?
NCI-H1304 NHz4TWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUC4SWVYUUN3ME2wMlExPTl2IN88US=> NGiwWVVUSU6JRWK=
L-540 MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr6TWM2OD1yLkGwO|A5KM7:TR?= NYDDT3hpW0GQR1XS
NCI-SNU-16 NVvzSo94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LON2lEPTB;MD6xNFc1OiEQvF2= Mn7wV2FPT0WU
HD-MY-Z M1rZTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMUC4OVYh|ryP NWG1U5dbW0GQR1XS
K-562 NFHZS25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorlTWM2OD1yLkGwPFU5KM7:TR?= NVHnV|JQW0GQR1XS
JAR M2DZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMUC5NlUh|ryP MnvqV2FPT0WU
MZ2-MEL MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMUGwOUDPxE1? MVHTRW5ITVJ?
L-363 MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHEeVZHUUN3ME2wMlEyODd7IN88US=> NG\HWppUSU6JRWK=
BV-173 NEXIZ2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nGWmlEPTB;MD6xNVI1OyEQvF2= MYPTRW5ITVJ?
NCI-H524 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMUGyO|Qh|ryP NYPjXZdoW0GQR1XS
EoL-1-cell MmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Da[2lEPTB;MD6xNVY4OiEQvF2= NEDDU4tUSU6JRWK=
K052 NF3uNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVm0RYdTUUN3ME2wMlEyPzF{IN88US=> M2D2ZnNCVkeHUh?=
TK10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rufGlEPTB;MD6xNVczQCEQvF2= NHLnU3ZUSU6JRWK=
KU812 NYfPUJJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XRS2lEPTB;MD6xNlA1PCEQvF2= MnTBV2FPT0WU
RPMI-8226 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPqTWM2OD1yLkGyNFUzKM7:TR?= NFLUW|JUSU6JRWK=
MZ7-mel MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fsdGlEPTB;MD6xNlI{PyEQvF2= MoLMV2FPT0WU
SK-PN-DW M3vmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3ITWM2OD1yLkGyNlg4KM7:TR?= NFTk[WpUSU6JRWK=
SR NEjmbFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4mxTmlEPTB;MD6xNlQ1OSEQvF2= MnTsV2FPT0WU
RPMI-6666 NUHNdnlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTXRoNKSzVyPUCuNVI4PDNizszN MnLKV2FPT0WU
no-11 NVHwboVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnhT4pKSzVyPUCuNVI5PjlizszN M3znOHNCVkeHUh?=
EW-3 NI[wVm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fwcWlEPTB;MD6xNlg6OyEQvF2= M{\ENXNCVkeHUh?=
LAMA-84 MmDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:5Z2lEPTB;MD6xN|E5PyEQvF2= MWTTRW5ITVJ?
HT Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMUO1O|Qh|ryP MYXTRW5ITVJ?
KP-N-RT-BM-1 MmjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMUO2NVIh|ryP NEDIXFFUSU6JRWK=
NCI-H747 M4LDbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvocllMUUN3ME2wMlE{PyEQvF2= Mo\3V2FPT0WU
NCCIT NWOyeolHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXqe45KSzVyPUCuNVM6OzlizszN NEXMS3VUSU6JRWK=
MLMA MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnUVIJKSzVyPUCuNVQyPjdizszN MnLPV2FPT0WU
LP-1 NH\qfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET5eIlKSzVyPUCuNVQzPCEQvF2= NVS0S|VRW0GQR1XS
CAL-148 M1m5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHlXW03UUN3ME2wMlE1PDh|IN88US=> MYLTRW5ITVJ?
GB-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMUS1NlYh|ryP NIrTOVlUSU6JRWK=
COR-L88 NF7p[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHudZhKSzVyPUCuNVQ5ODJizszN MWHTRW5ITVJ?
NKM-1 NH72Z5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrYTWM2OD1yLkG0PVA3KM7:TR?= M3HaSnNCVkeHUh?=
NB5 NEjkbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzrWFM{UUN3ME2wMlE2PDZ{IN88US=> M3fad3NCVkeHUh?=
SH-4 M3nIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Kyd2lEPTB;MD6xOVQ3PiEQvF2= M3fLUHNCVkeHUh?=
EM-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHHTWM2OD1yLkG1OFY4KM7:TR?= M3TQNXNCVkeHUh?=
TGBC24TKB MkLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnr[XdKSzVyPUCuNVU3PTlizszN NXTRc|RiW0GQR1XS
SCLC-21H MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHER5NKSzVyPUCuNVU4ODJizszN NHKxb41USU6JRWK=
COLO-684 Mmn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDROlgxUUN3ME2wMlE2PzJzIN88US=> NH;kfpBUSU6JRWK=
KINGS-1 NGXLR2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS0WXhKSzVyPUCuNVU6OSEQvF2= Mnm0V2FPT0WU
LS-123 NFPYdZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTYUJlwUUN3ME2wMlE2QTF5IN88US=> MlnwV2FPT0WU
MC116 M2DlTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMU[xOVgh|ryP M2PIe3NCVkeHUh?=
SU-DHL-1 MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S1XmlEPTB;MD6xOlIxPiEQvF2= M1LFO3NCVkeHUh?=
NCI-H64 NVXSTnJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMU[zOFch|ryP M1\KOnNCVkeHUh?=
HCE-T MmPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\G[XJHUUN3ME2wMlE3PTB2IN88US=> NFjJVXZUSU6JRWK=
LOXIMVI MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMU[5OFkh|ryP MnLhV2FPT0WU
ARH-77 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TjU2lEPTB;MD6xO|M4QSEQvF2= NHTLSpFUSU6JRWK=
DOHH-2 NYfFZldLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\hTWM2OD1yLkG3OlczKM7:TR?= MYfTRW5ITVJ?
COLO-320-HSR MmfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLm[o9KUUN3ME2wMlE5OTV2IN88US=> NGDFb4JUSU6JRWK=
NB6 M4PGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nHOWlEPTB;MD6xPFU3PiEQvF2= MmX4V2FPT0WU
L-428 NF3Bb5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMUi4NVMh|ryP NVHJWYdTW0GQR1XS
SNB75 M1\0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfL[nM{UUN3ME2wMlE5QDJ2IN88US=> NGDyOYtUSU6JRWK=
NCI-H2141 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTtTWM2OD1yLkG5NFEyKM7:TR?= MnjKV2FPT0WU
KARPAS-299 M2OwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGG4[WRKSzVyPUCuNVkzPDFizszN NGSxeYVUSU6JRWK=
LC4-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnpTWM2OD1yLkG5OVAzKM7:TR?= MWTTRW5ITVJ?
UACC-257 Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrTOI1KSzVyPUCuNVk6PDdizszN NEfsNGpUSU6JRWK=
EVSA-T M4XXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HvRWlEPTB;MD6yNFMyOiEQvF2= M37rXXNCVkeHUh?=
JiyoyeP-2003 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjTN5dKSzVyPUCuNlA1PzdizszN MluwV2FPT0WU
NCI-H720 M3P1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMkC1NlUh|ryP MWTTRW5ITVJ?
GAK M2H5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2CwNGlEPTB;MD6yNVE5QSEQvF2= NWjTbJB3W0GQR1XS
HH MnnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzGTWM2OD1yLkKxOFA2KM7:TR?= MV;TRW5ITVJ?
NCI-H1436 NYfIcXBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnMNlFKSzVyPUCuNlE1PjRizszN MV3TRW5ITVJ?
GR-ST MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTFTWM2OD1yLkKxOFg5KM7:TR?= NYPFOolLW0GQR1XS
BC-1 NECydoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPjTWM2OD1yLkKyOlE3KM7:TR?= NX:1ZXNPW0GQR1XS
SIG-M5 NFfJOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm3TWM2OD1yLkKyO|I4KM7:TR?= MmK0V2FPT0WU
NCI-H345 NU[0Sm8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Lm[2lEPTB;MD6yN|gxPSEQvF2= NGLsOpNUSU6JRWK=
OPM-2 MmDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3JeXRKSzVyPUCuNlM5QDJizszN MYnTRW5ITVJ?
LB1047-RCC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvTTWM2OD1yLkK0OFEh|ryP NVG0RYd6W0GQR1XS
CTB-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMkS0PVMh|ryP NXnkVYx1W0GQR1XS
A3-KAW MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W4[WlEPTB;MD6yOVM1OSEQvF2= MWXTRW5ITVJ?
SF126 MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfKN4plUUN3ME2wMlI2Ozh|IN88US=> MkPlV2FPT0WU
KARPAS-422 NFzLU5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMkW0N|Uh|ryP MonDV2FPT0WU
MEG-01 M1jPfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\QNWlEPTB;MD6yOVY4OyEQvF2= NFzEem1USU6JRWK=
NCI-H209 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPSWppKSzVyPUCuNlY{PzRizszN NIT6NVBUSU6JRWK=
SBC-1 NUnrcohXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMk[1JO69VQ>? NV2wOIJNW0GQR1XS
K5 NYDG[3V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomzTWM2OD1yLkK2PVg1KM7:TR?= NGW1eFRUSU6JRWK=
QIMR-WIL M{nuXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnvOXpKSzVyPUCuNlcyPTVizszN MkWyV2FPT0WU
NMC-G1 NFjTUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXId5dKSzVyPUCuNlgzOTdizszN MVrTRW5ITVJ?
IST-MES1 NY[yfXFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnDbnBKSzVyPUCuNlkzOzhizszN MoroV2FPT0WU
SW684 NIj3NGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrGVYhKSzVyPUCuN|AxPDdizszN NVTNboJuW0GQR1XS
MV-4-11 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofnTWM2OD1yLkOwO|g5KM7:TR?= M2LCV3NCVkeHUh?=
LAN-6 NGPTO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXThR5piUUN3ME2wMlMyPTd{IN88US=> NG\HeoJUSU6JRWK=
RH-1 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHnTWM2OD1yLkOxPFcyKM7:TR?= M1v5UHNCVkeHUh?=
CP66-MEL NXrDb5R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jVdWlEPTB;MD6zNVg4QCEQvF2= NX2xcJZQW0GQR1XS
EC-GI-10 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnYWmgzUUN3ME2wMlMzQTh5IN88US=> NEG2e3JUSU6JRWK=
GDM-1 NV6zOoI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwM{OwOVkh|ryP MX;TRW5ITVJ?
IST-SL1 M4DnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3G5[WlEPTB;MD6zOFkyPCEQvF2= M3y3THNCVkeHUh?=
KMOE-2 NW\IUlF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX4TlQ4UUN3ME2wMlM2OTd3IN88US=> MoTXV2FPT0WU
OS-RC-2 NG\ybnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPMSmRKSzVyPUCuN|U2PDRizszN MYfTRW5ITVJ?
HDLM-2 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zhN2lEPTB;MD6zO|gyPCEQvF2= NIf6VYZUSU6JRWK=
DSH1 NHLMTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;iOHVKSzVyPUCuN|g3OzFizszN NV70U2ZsW0GQR1XS
LS-1034 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInJdlFKSzVyPUCuN|g6PTRizszN NHrxfJVUSU6JRWK=
LB373-MEL-D M3K1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrjVlRbUUN3ME2wMlM6OTl5IN88US=> NELL[oRUSU6JRWK=
GOTO M3j6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwNEKxNVgh|ryP Mn[xV2FPT0WU
MRK-nu-1 MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLKT|NxUUN3ME2wMlQzOjB3IN88US=> NVnjVGM1W0GQR1XS
SK-MM-2 NHflRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlu5TWM2OD1yLkSzOFQzKM7:TR?= NHrvbZVUSU6JRWK=
BOKU MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwNEO3PVIh|ryP M1jrfnNCVkeHUh?=
NOMO-1 NGG3NW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP2TWM2OD1yLkSzPFYh|ryP MkLqV2FPT0WU
J-RT3-T3-5 M3;Fd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNES4O|gh|ryP MWfTRW5ITVJ?
COLO-668 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rSfWlEPTB;MD60OVY3QCEQvF2= MlqxV2FPT0WU
SF539 MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlL0TWM2OD1yLkS4Olg1KM7:TR?= NELpe4dUSU6JRWK=
LB2518-MEL Mn;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDmTWM2OD1yLkS5O|A{KM7:TR?= M3LRd3NCVkeHUh?=
TE-441-T NGPtRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXhOZdKSzVyPUCuOVAyOiEQvF2= NY\ue4x7W0GQR1XS
MDA-MB-134-VI MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v1SmlEPTB;MD61NFkzOSEQvF2= MV;TRW5ITVJ?
SCC-3 M4rBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzUR2pzUUN3ME2wMlUyQDd|IN88US=> M1[xbXNCVkeHUh?=
KLE NUXkOJVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\OXnNJUUN3ME2wMlUzOTdzIN88US=> M4XtOnNCVkeHUh?=
LB2241-RCC NU[3XXVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi3TWM2OD1yLkWyOVI2KM7:TR?= M3\tUXNCVkeHUh?=
NCI-H1417 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITNUnNKSzVyPUCuOVM1OzVizszN NXnDUFlYW0GQR1XS
NCI-H2081 M{LtVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Dj[WlEPTB;MD61PFYyOSEQvF2= NXSzZ5dsW0GQR1XS
NCI-H1522 NGHPOIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwNUmzPFMh|ryP NV\1S3dvW0GQR1XS
NCI-H889 NXXG[mlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwNUm4OFQh|ryP MmTTV2FPT0WU
CGTH-W-1 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\Ob|BOUUN3ME2wMlYxPzV3IN88US=> MX;TRW5ITVJ?
EB-3 MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fZU2lEPTB;MD62NVE2OyEQvF2= NF3ERZNUSU6JRWK=
D-336MG NHzQVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwNkG3PVEh|ryP NX:0PYlRW0GQR1XS
LC-1F MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHFTpR4UUN3ME2wMlYzPTl{IN88US=> MWHTRW5ITVJ?
MHH-NB-11 M4\6O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXGxeFBUUUN3ME2wMlY{QDBzIN88US=> M3;lb3NCVkeHUh?=
SK-N-FI NUfLTYZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7CWo9KSzVyPUCuOlM6OSEQvF2= Ml;DV2FPT0WU
NCI-H69 M3uzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES2cW1KSzVyPUCuOlQ5PzlizszN M1HMXXNCVkeHUh?=
SCH NWjBTmpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TMUmlEPTB;MD62OlAzOyEQvF2= M1n1XXNCVkeHUh?=
LS-513 M4P5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP0TWM2OD1yLk[3NlU6KM7:TR?= MWLTRW5ITVJ?
CP67-MEL MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwNke1PVYh|ryP MV\TRW5ITVJ?
GCIY NVnWSlNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTSNItKSzVyPUCuO|A{PjNizszN NIP4O2FUSU6JRWK=
SHP-77 Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwN{C3N|Qh|ryP NUfCTmZmW0GQR1XS
EHEB NECyT5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwN{G4OVQh|ryP MUDTRW5ITVJ?
D-247MG NXu4TVVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfXTWM2OD1yLkezNlMzKM7:TR?= NF7td4tUSU6JRWK=
Raji MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwN{S5PFkh|ryP NYnUe2F1W0GQR1XS
MPP-89 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPBfo5KSzVyPUCuO|U6PzhizszN Ml\zV2FPT0WU
EKVX MlruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfFTWM2OD1yLke5NFc{KM7:TR?= MYPTRW5ITVJ?
HCC2218 MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwN{mxN|Eh|ryP NIfhV25USU6JRWK=
KNS-81-FD NY\VbVJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HFbWlEPTB;MD64NVAyOSEQvF2= MWXTRW5ITVJ?
HCC2157 NGG4VmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXreZVKSzVyPUCuPFQ6PTFizszN NHHqTYhUSU6JRWK=
BT-474 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG1bohKSzVyPUCuPFg5PTRizszN MkHkV2FPT0WU
NCI-H748 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXMc2xKSzVyPUCuPVEzKM7:TR?= NVi3VpBVW0GQR1XS
EW-24 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknTTWM2OD1yLkmyNFAzKM7:TR?= M2j5RnNCVkeHUh?=
D-263MG NIKwVFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTJTWM2OD1yLkm0OVEzKM7:TR?= MkjCV2FPT0WU
OMC-1 NXjj[YJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX2TWM2OD1yLkm2N|c{KM7:TR?= MX;TRW5ITVJ?
NCI-H2196 NGfVXHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwOUe3O|ch|ryP M{nmW3NCVkeHUh?=
HAL-01 NGLYTnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:1TWM2OD1yLkm5PFczKM7:TR?= MkXYV2FPT0WU
NCI-H2107 Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X4[mlEPTB;MT6wNVg2PCEQvF2= NGPGdoJUSU6JRWK=
LB996-RCC NUPxZVU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;NdYxKSzVyPUGuNFgxPTFizszN NXXWRo15W0GQR1XS
NCI-H1395 MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rn[2lEPTB;MT6xNFY4KM7:TR?= NHe4[JVUSU6JRWK=
CHP-126 NU\JdYNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XJWmlEPTB;MT6xOlE6QSEQvF2= M3P5XHNCVkeHUh?=
NB69 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTFwMk[xOFgh|ryP MmHvV2FPT0WU
CAS-1 NHrwTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjFfHVKSzVyPUGuN|QzOzFizszN M2TSWnNCVkeHUh?=
JVM-3 NVnSXoFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXlTWM2OD1zLkS3PFU2KM7:TR?= MoP1V2FPT0WU
DMS-153 NH3ySZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;RbGlEPTB;MT61O|Y4PCEQvF2= MX;TRW5ITVJ?
SK-MEL-2 M13jdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnzd25KSzVyPUGuO|E4QDlizszN MYPTRW5ITVJ?
NCI-H1155 NUPmOpp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTFwN{O2O|Yh|ryP NHjFV3dUSU6JRWK=
NCI-H1092 NIXEZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PiZmlEPTB;MT63OlE5OiEQvF2= MoGzV2FPT0WU
LU-165 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjHeHlCUUN3ME2xMlg3PDd4IN88US=> NWTjOW1IW0GQR1XS
HL-60 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXsTWM2OD1zLkm5PVA5KM7:TR?= MkTLV2FPT0WU
REH M4TQXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJwMEC1PFIh|ryP Mk\vV2FPT0WU
JVM-2 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnMTWM2OD1{LkC2NVM2KM7:TR?= NWLyNlNlW0GQR1XS
MN-60 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvuTWM2OD1{LkG3N|A5KM7:TR?= MYXTRW5ITVJ?
SCC-15 MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj1ZoI3UUN3ME2yMlIxOjdizszN MXTTRW5ITVJ?
SNU-C1 NUXJUXN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTJUXlKSzVyPUKuNlE{PDNizszN NG[0cWpUSU6JRWK=
SK-MEL-1 NWX1XoJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzJTWM2OD1{LkOyNFQ4KM7:TR?= M13KN3NCVkeHUh?=
TGW MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\wbVBrUUN3ME2yMlM2ODJ5IN88US=> MoC1V2FPT0WU
CA46 NWCxW5Y1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz6NHFKSzVyPUKuO|U6PjdizszN MVnTRW5ITVJ?
NCI-H23 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rROGlEPTB;Mj64NFc6OSEQvF2= MYjTRW5ITVJ?
MMAC-SF NWiyVZRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJwOE[2Nlgh|ryP M33BbnNCVkeHUh?=
NCI-H2171 NWKyUVc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTNwMEO0OFgh|ryP MVLTRW5ITVJ?
A704 NFmxV4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTNwMUSxPVQh|ryP MX\TRW5ITVJ?
DB MoD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTNwMkW1O|Yh|ryP MU\TRW5ITVJ?
NCI-H719 NVW5c3Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi1VnByUUN3ME2zMlMxOzh2IN88US=> MmDiV2FPT0WU
MC-CAR MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTNwNUS4NVch|ryP M4\XUnNCVkeHUh?=
SIMA NWnSTW02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[0O2pKSzVyPUOuOVg1OTZizszN NIX1[YFUSU6JRWK=
SW872 NYnreIVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\LTWM2OD1|Lke4NVAyKM7:TR?= M4SxcXNCVkeHUh?=
HCC1187 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfNRWlKSzVyPUOuO|g{OTVizszN Mle0V2FPT0WU
EW-13 NILhcHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG4PXhQUUN3ME2zMlg{PDF5IN88US=> NWLHUlFMW0GQR1XS
NCI-SNU-1 NIXyW3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvZfW5KSzVyPUSuNlE6QTlizszN NUe1VoE1W0GQR1XS
NCI-H226 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnxOHpKSzVyPUSuN|M3ODZizszN MkXaV2FPT0WU
RPMI-8866 NH;jRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1SxWmlEPTB;ND6zOlAzQSEQvF2= NYnEZWNoW0GQR1XS
OCI-AML2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jXSWlEPTB;ND61OVI{KM7:TR?= Mlr0V2FPT0WU
LU-65 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDtTWM2OD12LkmzNFM{KM7:TR?= M3\SWXNCVkeHUh?=
SK-N-DZ NUXrbZN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S2PWlEPTB;NT62N|Q3PSEQvF2= MlvYV2FPT0WU
NB14 MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XOfGlEPTB;NT65O|E{PSEQvF2= M4XafnNCVkeHUh?=
COLO-829 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYmyUWo{UUN3ME22MlM{OzV7IN88US=> NHPJUHBUSU6JRWK=
MHH-CALL-2 NFPjR45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHWXYdoUUN3ME22MlUyPTB6IN88US=> NIi4fmVUSU6JRWK=
NCI-H1770 M2TjSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K3dWlEPTB;Nj62OlkxPCEQvF2= MVXTRW5ITVJ?
ECC4 NGDNdmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTZwOEKxO|kh|ryP MX3TRW5ITVJ?
A498 MnrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nncWlEPTB;Nj64O|E6OiEQvF2= MkXPV2FPT0WU
DMS-79 NIrKN3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTdwMES1NVIh|ryP NXi5TnBKW0GQR1XS
P30-OHK NVjrRpFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MleyTWM2OD15LkKxPVA3KM7:TR?= MVPTRW5ITVJ?
D-502MG NHrxNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[w[VlTUUN3ME23Mlk5OzZizszN M4TjbXNCVkeHUh?=
RCC10RGB NWG4cXpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LkSWlEPTB;OD6wOlI5KM7:TR?= Mkj0V2FPT0WU
U-698-M MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLKNnpKSzVyPUiuNlkzOjZizszN NV3uVpJuW0GQR1XS
BB49-HNC MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHZTWM2OD17LkSyNlY2KM7:TR?= NHfRV5pUSU6JRWK=
ES1 NYLSN2hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXlOXdKSzVyPUmuOlg6PTZizszN Mm\FV2FPT0WU
MFM-223 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PnbGlEPTB;MUCuPVkzPyEQvF2= MYrTRW5ITVJ?
C2BBe1 MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHDTWM2OD1zMT6zOVI{KM7:TR?= NEDiNmxUSU6JRWK=
EB2 NWXUXYtnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M175SmlEPTB;MUKuOlg5OSEQvF2= MXLTRW5ITVJ?
C8166 NEHrO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfBeXE2UUN3ME2xN{45OzB|IN88US=> MoPxV2FPT0WU
ES3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTF|Lkm5O|ch|ryP MU\TRW5ITVJ?
NCI-H1650 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XiVmlEPTB;MU[uN|c3PSEQvF2= MoHZV2FPT0WU
Mo-T NVPjUph6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPLTWM2OD1zNz60NFI6KM7:TR?= NYr1b4VXW0GQR1XS
NB7 M{DWdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHWzbotKSzVyPUG3Mlc1PjdizszN MWPTRW5ITVJ?
ES7 NH;uRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDDO49KSzVyPUG5MlU2ODdizszN Mmn2V2FPT0WU
ES5 NYrFcG0xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTVe3I2UUN3ME2yNU44PjdzIN88US=> NH\POmRUSU6JRWK=
MSTO-211H M2L4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJzLki4OVgh|ryP NGrF[G5USU6JRWK=
U-87-MG M2TYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYn0bG1vUUN3ME2yOU4yQTZ4IN88US=> MofBV2FPT0WU
THP-1 M3Ln[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjhTWM2OD1{OT63NlAyKM7:TR?= MWXTRW5ITVJ?
NB10 Ml\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;2U404UUN3ME2zNE4zPjl2IN88US=> NYGwSoNQW0GQR1XS
NH-12 NEXQeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HGOGlEPTB;M{OuNlAyPyEQvF2= NYnaR5RRW0GQR1XS
COLO-824 MoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvtdFlQUUN3ME2zOE4yODB4IN88US=> NXL0bIRWW0GQR1XS
SKM-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrBZo9KSzVyPUO3Mlg1OjJizszN NIXVO4RUSU6JRWK=
NCI-H1838 NF;4emRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTsXHpUUUN3ME2zPE4{Pzl5IN88US=> MnvkV2FPT0WU
RL NVLHWYZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fDemlEPTB;M{muNlQ4PyEQvF2= NU\JcVJJW0GQR1XS
COLO-800 MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPNWWdKSzVyPUSwMlA4PzNizszN MYDTRW5ITVJ?
KG-1 M4fzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXOXnRKSzVyPUSwMlg6PTVizszN NGDWenZUSU6JRWK=
TUR MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LSOmlEPTB;NEGuOlM6QSEQvF2= NFLLVJZUSU6JRWK=
LNCaP-Clone-FGC Mkj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n6V2lEPTB;NEGuPVAyPyEQvF2= MoHpV2FPT0WU
NCI-H322M MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTEV|JPUUN3ME20Nk42QTh2IN88US=> MmrmV2FPT0WU
LNCaP  NXLpNHAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjJSYVoUUN3ME25NU4{KG6P MlryNlU2ODVzN{S=
C4-2 MoDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfoW3NKSzVyPUigcm0> NFjpR|kzPTVyNUG3OC=>
JURKAT M4fUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnaNIx3OjRiaB?= NV[3bWVXUUN3ME20NVYvPjZibl2= MUmyOFUyQTl7NR?=
MOLT-4 M{m3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\4T|I1KGh? MlzDTWM2OD1{OEWzMlUhdk1? MYKyOFUyQTl7NR?=
REH M3LFfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDkOYIzPCCq MXrJR|UxRTJ6Nz62PEBvVQ>? Mo\GNlQ2OTl7OUW=
NALM-6 MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPSNlQhcA>? NIjsfFFKSzVyPUO0N|MxKG6P MVmyOFUyQTl7NR?=
RS 4;11 MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXKcGczPCCq NVz5Z3RjUUN3ME21NVkvODVibl2= NGTuXWEzPDVzOUm5OS=>
697 NXKxbHYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TZSFI1KGh? NFfMfXpKSzVyPUKxNFcvOSCwTR?= MkfhNlQ2OTl7OUW=
SIL-ALL NIjtT|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3W[JgzPCCq M170N2lEPTB;MUm5Mlc4KG6P MWWyOFUyQTl7NR?=
CEM NFTkbWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPGTnF3OjRiaB?= M4X6NGlEPTB;NUKuNVghdk1? MYeyOFUyQTl7NR?=
P12 NWHZb5NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWqyOEBp Mk\ITWM2OD1|OT6yO{BvVQ>? M3XWfFI1PTF7OUm1
NALM-16 MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPpNlQhcA>? NUDCU3hyUUN3ME25Ok4zQCCwTR?= MkLlNlQ2OTl7OUW=
JURKAT NHTsUXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\GcYMyPDhiaB?= M4naTmlEPTB;MUSuPFQhdk1? MX:yOFUyQTl7NR?=
MOLT-4 M3fjN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITRfHA1QCCq MXfJR|UxRTJ4Lk[gcm0> NW\WdJJIOjR3MUm5PVU>
REH MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\XOFghcA>? M{DsV2lEPTB;NESuO|Ehdk1? MVOyOFUyQTl7NR?=
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... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

文献中の引用 (53)

Frequently Asked Questions

  • Question 1
    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

    Answer: For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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