BI 2536 化学構造
分子量: 521.66

高品質保証

文献中の引用(51)

カスタマーフィードバック(10)

Quality Control & MSDS

製品説明

  • Compare PLK Inhibitors
    PLK製品生物活性の比較
  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjNfpdKSzVyPUCuNFA4PzZizszN M3\NXXNCVkeHUh?=
ACN NXjIOHFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf1XYRKSzVyPUCuNFA5PDNizszN Mn3aV2FPT0WU
TE-8 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLFTWM2OD1yLkCwPVQyKM7:TR?= MYDTRW5ITVJ?
LC-2-ad MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMEGwPVMh|ryP MoTGV2FPT0WU
ALL-PO MonMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3i5PGlEPTB;MD6wNVMh|ryP MXnTRW5ITVJ?
EW-16 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEGzN|Yh|ryP MWHTRW5ITVJ?
KM12 NWD2ZmZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfTR4tKSzVyPUCuNFE{PDhizszN NVjP[IlFW0GQR1XS
GI-1 MknyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H0NGlEPTB;MD6wNVM5OyEQvF2= Mkn6V2FPT0WU
LS-411N MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfFUHZCUUN3ME2wMlAyPDB5IN88US=> MV7TRW5ITVJ?
ES8 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEG0PVQh|ryP M{i3bXNCVkeHUh?=
SNU-C2B M3LSTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEG1NlYh|ryP NI\Y[nZUSU6JRWK=
CESS NIXmUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mni3TWM2OD1yLkCxOlAzKM7:TR?= NXHNd5pHW0GQR1XS
697 M2f4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7tTWM2OD1yLkCxOlY5KM7:TR?= NIPEco1USU6JRWK=
NCI-H1963 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\lV|BRUUN3ME2wMlAyPjd|IN88US=> NXr1S|Z1W0GQR1XS
IA-LM NXHydVJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS0NmdKSzVyPUCuNFE3QDhizszN NXK1Xm9LW0GQR1XS
SW954 MlfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon3TWM2OD1yLkCxO|A2KM7:TR?= NHfGfYZUSU6JRWK=
RL95-2 M2fMcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXpTWM2OD1yLkCxO|M5KM7:TR?= NYfQfHFuW0GQR1XS
LXF-289 NEnHUItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEG3O{DPxE1? MXTTRW5ITVJ?
OCUB-M M2jNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEG4NlYh|ryP NHqwVolUSU6JRWK=
RKO M1zCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEG5PFch|ryP MmTLV2FPT0WU
LOUCY NXLSNFdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoCyTWM2OD1yLkCyNFUh|ryP Mlj0V2FPT0WU
NOS-1 NHjoTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DZV2lEPTB;MD6wNlA6OyEQvF2= NFzJdHFUSU6JRWK=
A4-Fuk NYTnV2RuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrScVVKSzVyPUCuNFIzOThizszN M4HQdXNCVkeHUh?=
A388 NYLiVGN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zvcWlEPTB;MD6wNlIzPyEQvF2= NX7iV2lRW0GQR1XS
TE-9 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEKyOlEh|ryP MnnFV2FPT0WU
KURAMOCHI MoPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnKTHl7UUN3ME2wMlAzOjh3IN88US=> MVzTRW5ITVJ?
KALS-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfwTWM2OD1yLkCyN|M5KM7:TR?= M{O3XXNCVkeHUh?=
HOP-62 M1f6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm0fGFjUUN3ME2wMlAzPDJizszN MkjiV2FPT0WU
RPMI-8402 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMEK1NFgh|ryP MmKwV2FPT0WU
TE-1 MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEK1NVIh|ryP NULyTm5qW0GQR1XS
CCRF-CEM M2n0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEK1OFMh|ryP NXLwfIFyW0GQR1XS
HUTU-80 NGC5[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TReWlEPTB;MD6wNlYzPCEQvF2= MX7TRW5ITVJ?
NCI-H1648 NXzEbHhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGwR|dKSzVyPUCuNFI3PDdizszN Ml7JV2FPT0WU
HCE-4 NXTsVm5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEK2PFIh|ryP M3f6S3NCVkeHUh?=
ETK-1 M{PMWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEK3N|Yh|ryP Mn7jV2FPT0WU
TE-15 NGTmR5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzsbVhKSzVyPUCuNFI4OzhizszN NEju[21USU6JRWK=
BE-13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTSfJAxUUN3ME2wMlAzPzRizszN NFH4W5ZUSU6JRWK=
KE-37 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3THcWlEPTB;MD6wNlc1OSEQvF2= Mm[xV2FPT0WU
NCI-H1355 MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjpOJlKSzVyPUCuNFI4QDNizszN M4\BSXNCVkeHUh?=
TE-11 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEK4NFkh|ryP MYDTRW5ITVJ?
BL-70 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXTWINKSzVyPUCuNFI5PTdizszN MXfTRW5ITVJ?
ES6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TTbGlEPTB;MD6wNlg5OSEQvF2= MUPTRW5ITVJ?
GT3TKB NVHJeGlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj4TFlNUUN3ME2wMlAzQTV|IN88US=> MlfoV2FPT0WU
LB647-SCLC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMEOxPVUh|ryP NF23SI1USU6JRWK=
NB13 NIX3ZVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMEOzNVYh|ryP NXn5TlVSW0GQR1XS
ST486 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnJeoZ2UUN3ME2wMlA{OzN5IN88US=> MYDTRW5ITVJ?
NCI-H82 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEOzOFMh|ryP M4rxNXNCVkeHUh?=
NTERA-S-cl-D1 NIXQN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHSNXdKSzVyPUCuNFM{QTlizszN MlLOV2FPT0WU
ES4 M2Pub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjIS29NUUN3ME2wMlA{PDZ|IN88US=> M1:xTnNCVkeHUh?=
SK-NEP-1 MlnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMEO0PVkh|ryP NFOwWYRUSU6JRWK=
Becker NYmx[odTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjzNoNKSzVyPUCuNFM2PTVizszN MWjTRW5ITVJ?
A101D M2XVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4ewVWlEPTB;MD6wN|c1QCEQvF2= M4rlcnNCVkeHUh?=
SK-UT-1 NF7XVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEO3O|Qh|ryP MX\TRW5ITVJ?
SW982 NXfRdo1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkO1TWM2OD1yLkCzO|kh|ryP MmPhV2FPT0WU
TE-10 MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL3UlJFUUN3ME2wMlA1ODR4IN88US=> MnLEV2FPT0WU
OVCAR-4 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfTb5FGUUN3ME2wMlA1ODV7IN88US=> NXi0S4RsW0GQR1XS
KP-N-YS NHK3TnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e4W2lEPTB;MD6wOFA5PSEQvF2= NFfLOnhUSU6JRWK=
BL-41 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LJcGlEPTB;MD6wOFEzPSEQvF2= MXXTRW5ITVJ?
MZ1-PC NF;FO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMESxNlch|ryP MkjpV2FPT0WU
PF-382 NWHYWm5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnBTWM2OD1yLkC0NVk5KM7:TR?= M2TzPHNCVkeHUh?=
MOLT-13 M3;Rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LZPGlEPTB;MD6wOFI{QCEQvF2= MVHTRW5ITVJ?
HCC1599 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvmTWM2OD1yLkC0NlU5KM7:TR?= M2nYSnNCVkeHUh?=
IST-MEL1 NGXhUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnmZ2Q3UUN3ME2wMlA1PDR{IN88US=> MWfTRW5ITVJ?
LU-139 NVTlcVJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvNeINJUUN3ME2wMlA1PDR{IN88US=> M2nJdnNCVkeHUh?=
MS-1 NXXrO4t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\4TZVGUUN3ME2wMlA1PzBzIN88US=> MmCxV2FPT0WU
MFH-ino NVW1WHlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X5cmlEPTB;MD6wOVAxOyEQvF2= NVPRcGN{W0GQR1XS
IMR-5 M2fjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjsTWM2OD1yLkC1NFIyKM7:TR?= M3ji[XNCVkeHUh?=
TE-5 MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnGe3BkUUN3ME2wMlA2ODZ|IN88US=> MXvTRW5ITVJ?
DJM-1 Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTiPG9KSzVyPUCuNFUyPDJizszN NIHtOoJUSU6JRWK=
NB17 NWTpPFFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMEWyNFch|ryP NGToZYZUSU6JRWK=
KARPAS-45 M2O2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\BWWlEPTB;MD6wOVM2QCEQvF2= MXfTRW5ITVJ?
TGBC1TKB MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEW0NFUh|ryP NF;zXppUSU6JRWK=
ML-2 Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHsc2gzUUN3ME2wMlA2PDF2IN88US=> NEnqRYNUSU6JRWK=
no-10 NHHXS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\zXWlEPTB;MD6wOVQ4PCEQvF2= MmTnV2FPT0WU
CTV-1 NVLNdJNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S2N2lEPTB;MD6wOVUxOiEQvF2= NYLqd3gyW0GQR1XS
SJSA-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP5SmVKSzVyPUCuNFU2OiEQvF2= MknwV2FPT0WU
HC-1 M2LuRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEW1PVch|ryP M4LsTnNCVkeHUh?=
TE-12 MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofuTWM2OD1yLkC1OlE{KM7:TR?= MXrTRW5ITVJ?
KY821 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEmyRZdKSzVyPUCuNFU3OzJizszN M1v2TnNCVkeHUh?=
TALL-1 NYjBfoh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrrTWM2OD1yLkC1O|A5KM7:TR?= MmGxV2FPT0WU
DEL M1z0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrNOFVKSzVyPUCuNFU4ODlizszN NXTifHVnW0GQR1XS
TE-6 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPuTGNKSzVyPUCuNFU4OjJizszN MXfTRW5ITVJ?
SK-LMS-1 M{ntNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEW4NFUh|ryP NFTHb|BUSU6JRWK=
EW-1 MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof4TWM2OD1yLkC1PFM4KM7:TR?= NHXNSYpUSU6JRWK=
8-MG-BA MkPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEW4OVEh|ryP NWSzV3NqW0GQR1XS
NALM-6 MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fZWGlEPTB;MD6wOVk4OyEQvF2= MlXMV2FPT0WU
LB771-HNC M{H2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fFVGlEPTB;MD6wOVk4QSEQvF2= NFH4dWhUSU6JRWK=
HT-144 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;qPGlEPTB;MD6wOlE{KM7:TR?= NVrsXYVQW0GQR1XS
KM-H2 NVH0fJBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwME[yNlEh|ryP MUjTRW5ITVJ?
SF268 NIPDZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLDOHhCUUN3ME2wMlA3Ojh4IN88US=> MoTzV2FPT0WU
RS4-11 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rGT2lEPTB;MD6wOlMxPCEQvF2= NVe0Rm5LW0GQR1XS
MHH-PREB-1 NIqxR|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3IeG52UUN3ME2wMlA3OzF7IN88US=> MknTV2FPT0WU
ATN-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj2W4NKSzVyPUCuNFY{PDVizszN NYSxSlNtW0GQR1XS
BB30-HNC MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rxdWlEPTB;MD6wOlQ{PiEQvF2= MWHTRW5ITVJ?
CPC-N NWi4[|VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFOwXYxKSzVyPUCuNFY2OjRizszN NWLmWXl4W0GQR1XS
NB1 NYPafHdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwME[2NVMh|ryP MUDTRW5ITVJ?
KS-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwME[3OFgh|ryP M4\Yb3NCVkeHUh?=
RXF393 M{TuT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwME[3OlQh|ryP NYL4TJg5W0GQR1XS
IST-SL2 NX\UN2p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fNSGlEPTB;MD6wO|AxPCEQvF2= MlXmV2FPT0WU
GI-ME-N NULTb3EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMEeyPFYh|ryP MVLTRW5ITVJ?
VA-ES-BJ NX;XXoliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[3TWM2OD1yLkC3OFc2KM7:TR?= NXSy[2tTW0GQR1XS
NCI-H1581 MmnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPLTWM2OD1yLkC3OFc5KM7:TR?= NGHQNmNUSU6JRWK=
U-266 M1fORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zSXGlEPTB;MD6wO|Q6PyEQvF2= M1\p[3NCVkeHUh?=
DMS-114 M1POOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEe1Nlgh|ryP NHPK[HJUSU6JRWK=
NCI-H187 NEDPcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXTTWM2OD1yLkC3O|I3KM7:TR?= NW\yNm9vW0GQR1XS
SW962 NV72S3FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrjV2pKSzVyPUCuNFc5OzlizszN MW\TRW5ITVJ?
MONO-MAC-6 M1i3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzHTWM2OD1yLkC3PVg3KM7:TR?= NUTWWZlFW0GQR1XS
MOLT-16 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjIWXJKSzVyPUCuNFgyOjFizszN MknJV2FPT0WU
KNS-42 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLETWM2OD1yLkC4NVYyKM7:TR?= M2CzcHNCVkeHUh?=
CMK M{\aPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jUS2lEPTB;MD6wPFIzPSEQvF2= MkLIV2FPT0WU
Ramos-2G6-4C10 NYP2PIJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\VeWlEPTB;MD6wPFIzPSEQvF2= NVLPdpFEW0GQR1XS
Daudi NFewelBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTjTWM2OD1yLkC4NlU3KM7:TR?= MkXMV2FPT0WU
NCI-H510A MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvWWG1ZUUN3ME2wMlA5OzN4IN88US=> NGXkPVJUSU6JRWK=
LB831-BLC NUnaZXg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33sW2lEPTB;MD6wPFU3OSEQvF2= NUW3dVBuW0GQR1XS
HEL NVPQS3UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDCRYNKSzVyPUCuNFg3PjhizszN NV3KOXdLW0GQR1XS
LU-134-A MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEi3NFgh|ryP NGn5SlVUSU6JRWK=
NCI-H1694 M1HpN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkixTWM2OD1yLkC4O|Q1KM7:TR?= MmfYV2FPT0WU
KGN MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHIVnRKSzVyPUCuNFg4PTlizszN M3LzTXNCVkeHUh?=
A253 NE\tTJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEi4NlIh|ryP M2HMOnNCVkeHUh?=
DG-75 NGCxWotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NViyPZlVUUN3ME2wMlA5QTJ{IN88US=> NHfYR2ZUSU6JRWK=
MOLT-4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HIOmlEPTB;MD6wPFk5OyEQvF2= NETzSHpUSU6JRWK=
NCI-SNU-5 NWrlTmdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{WzNmlEPTB;MD6wPVI2QCEQvF2= NHjRSmxUSU6JRWK=
ONS-76 NHzaR3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL4S4RKSzVyPUCuNFkzPzZizszN M2PQRnNCVkeHUh?=
NCI-H446 MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPoTWM2OD1yLkC5OFYzKM7:TR?= NFzqWm1USU6JRWK=
COR-L279 NEDuTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjHZZVKSzVyPUCuNFk2PTZizszN Mnj0V2FPT0WU
Calu-6 NUjBUY5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nzUmlEPTB;MD6wPVU6QCEQvF2= Mnn6V2FPT0WU
BC-3 NFz4RXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{W2cGlEPTB;MD6wPVY3OiEQvF2= M3vVUHNCVkeHUh?=
NCI-H2126 M4DGdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK1cVBsUUN3ME2wMlA6PzlzIN88US=> M4S3[3NCVkeHUh?=
NCI-H1882 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTMfWhrUUN3ME2wMlA6QDB7IN88US=> NH;hcW5USU6JRWK=
BB65-RCC M13L[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XOeWlEPTB;MD6xNFI6PCEQvF2= MnzwV2FPT0WU
DU-4475 NXPQVmg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HUVGlEPTB;MD6xNFQxPyEQvF2= M2G0dHNCVkeHUh?=
NCI-H526 M3\NcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1izVWlEPTB;MD6xNFQ1KM7:TR?= NU\QbotxW0GQR1XS
NEC8 NH7tWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3WcplKSzVyPUCuNVA2OjVizszN NXz2[YhxW0GQR1XS
NCI-H1304 Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMUC1PVQh|ryP MlzDV2FPT0WU
L-540 M{n1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGwOJNKSzVyPUCuNVA4ODhizszN MXTTRW5ITVJ?
NCI-SNU-16 MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMUC3OFIh|ryP NVe3dHN7W0GQR1XS
HD-MY-Z NXPZVnliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLRTWM2OD1yLkGwPFU3KM7:TR?= NIr4d|RUSU6JRWK=
K-562 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMUC4OVgh|ryP NFSxV2FUSU6JRWK=
JAR NHXrbIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T6TGlEPTB;MD6xNFkzPSEQvF2= MWrTRW5ITVJ?
MZ2-MEL Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMUGwOUDPxE1? NYH0TolKW0GQR1XS
L-363 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rGc2lEPTB;MD6xNVA4QSEQvF2= MljnV2FPT0WU
BV-173 NHjGfmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHWbGRHUUN3ME2wMlEyOjR|IN88US=> MXzTRW5ITVJ?
NCI-H524 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvRTWM2OD1yLkGxNlc1KM7:TR?= NHfBTWxUSU6JRWK=
EoL-1-cell M4DlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLQV3RKSzVyPUCuNVE3PzJizszN MUHTRW5ITVJ?
K052 NWm2NlNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHGdYZKSzVyPUCuNVE4OTJizszN NIL4S5RUSU6JRWK=
TK10 NE[1doJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHCdY1KSzVyPUCuNVE4OjhizszN NELPWIxUSU6JRWK=
KU812 MoDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO5TWM2OD1yLkGyNFQ1KM7:TR?= M{\YWHNCVkeHUh?=
RPMI-8226 MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMUKwOVIh|ryP NIr4WlJUSU6JRWK=
MZ7-mel MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7SfI5[UUN3ME2wMlEzOjN5IN88US=> MnrzV2FPT0WU
SK-PN-DW MmDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLjTWM2OD1yLkGyNlg4KM7:TR?= NG\qN5dUSU6JRWK=
SR NHu2XItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fLeGlEPTB;MD6xNlQ1OSEQvF2= NXPDS3g2W0GQR1XS
RPMI-6666 NWDDe2Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHJWlJTUUN3ME2wMlEzPzR|IN88US=> Mm[5V2FPT0WU
no-11 M1HubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELJbZdKSzVyPUCuNVI5PjlizszN NEXPdGdUSU6JRWK=
EW-3 M{Xa[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIj6dG1KSzVyPUCuNVI5QTNizszN Ml3uV2FPT0WU
LAMA-84 NYrUNJBnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnEXpBGUUN3ME2wMlE{OTh5IN88US=> NV3ZOoxbW0GQR1XS
HT M2PDbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMUO1O|Qh|ryP NF3RWXNUSU6JRWK=
KP-N-RT-BM-1 MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMUO2NVIh|ryP NGrnS4xUSU6JRWK=
NCI-H747 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTQWGtsUUN3ME2wMlE{PyEQvF2= NUDjVII2W0GQR1XS
NCCIT M2fYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPCNVdUUUN3ME2wMlE{QTN7IN88US=> M4f1[HNCVkeHUh?=
MLMA M3H6O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPt[|VKSzVyPUCuNVQyPjdizszN M1G1cHNCVkeHUh?=
LP-1 NVnJSFVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMUSyOEDPxE1? NETY[oJUSU6JRWK=
CAL-148 MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMUS0PFMh|ryP NVOyUlM6W0GQR1XS
GB-1 NWe5[HlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\wdpBKSzVyPUCuNVQ2OjZizszN MmPvV2FPT0WU
COR-L88 NVftZpR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ftXGlEPTB;MD6xOFgxOiEQvF2= MY\TRW5ITVJ?
NKM-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHmdmc5UUN3ME2wMlE1QTB4IN88US=> M1m2[HNCVkeHUh?=
NB5 NYL2eZplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfSTWM2OD1yLkG1OFYzKM7:TR?= Ml;jV2FPT0WU
SH-4 NXzLNZRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjiTWM2OD1yLkG1OFY3KM7:TR?= MmfrV2FPT0WU
EM-2 NH7JZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HOWWlEPTB;MD6xOVQ3PyEQvF2= NI[3SYhUSU6JRWK=
TGBC24TKB NGeyeGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\JfGlEPTB;MD6xOVY2QSEQvF2= M{nhXHNCVkeHUh?=
SCLC-21H NFfEbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XUXGlEPTB;MD6xOVcxOiEQvF2= NGXDNnlUSU6JRWK=
COLO-684 MnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rycGlEPTB;MD6xOVczOSEQvF2= M13RT3NCVkeHUh?=
KINGS-1 NEH5SIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMUW5NUDPxE1? MX7TRW5ITVJ?
LS-123 MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXUc|BKSzVyPUCuNVU6OTdizszN M1\ueXNCVkeHUh?=
MC116 NEHkNHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnjTWM2OD1yLkG2NVU5KM7:TR?= MXTTRW5ITVJ?
SU-DHL-1 NFXlOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjPfoVKSzVyPUCuNVYzODZizszN NX;jbZlyW0GQR1XS
NCI-H64 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PLPWlEPTB;MD6xOlM1PyEQvF2= M2PuNXNCVkeHUh?=
HCE-T NX;Nc41FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rkW2lEPTB;MD6xOlUxPCEQvF2= MXLTRW5ITVJ?
LOXIMVI NXy2dHdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzVTWM2OD1yLkG2PVQ6KM7:TR?= M2[xXXNCVkeHUh?=
ARH-77 NFvldHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfkXo9KSzVyPUCuNVc{PzlizszN MVzTRW5ITVJ?
DOHH-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjGW3RKSzVyPUCuNVc3PzJizszN NY\ZVI0yW0GQR1XS
COLO-320-HSR Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInvfWNKSzVyPUCuNVgyPTRizszN Mlz5V2FPT0WU
NB6 M4j3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17ZZ2lEPTB;MD6xPFU3PiEQvF2= NUXofZJPW0GQR1XS
L-428 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPXTWM2OD1yLkG4PFE{KM7:TR?= NV3VXXFQW0GQR1XS
SNB75 NHe0fHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMUi4NlQh|ryP MnXrV2FPT0WU
NCI-H2141 NUDV[Il2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuzfm5YUUN3ME2wMlE6ODFzIN88US=> M2m4ZnNCVkeHUh?=
KARPAS-299 NVjEV4VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nBXGlEPTB;MD6xPVI1OSEQvF2= MonlV2FPT0WU
LC4-1 NF7oU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PtemlEPTB;MD6xPVUxOiEQvF2= MYfTRW5ITVJ?
UACC-257 M4n5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzBT5VKSzVyPUCuNVk6PDdizszN NF;OW2NUSU6JRWK=
EVSA-T MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMkCzNVIh|ryP MUTTRW5ITVJ?
JiyoyeP-2003 NVvWNmxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHtUIFiUUN3ME2wMlIxPDd5IN88US=> NGnhZnFUSU6JRWK=
NCI-H720 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXrVGdSUUN3ME2wMlIxPTJ3IN88US=> MUfTRW5ITVJ?
GAK MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13VfmlEPTB;MD6yNVE5QSEQvF2= MXPTRW5ITVJ?
HH NGf2dpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP0TWM2OD1yLkKxOFA2KM7:TR?= MnPDV2FPT0WU
NCI-H1436 NFjWXWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHkTWM2OD1yLkKxOFY1KM7:TR?= MUXTRW5ITVJ?
GR-ST NUW4SotST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrTOFNKSzVyPUCuNlE1QDhizszN Mn36V2FPT0WU
BC-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrCS3lGUUN3ME2wMlIzPjF4IN88US=> NH\GSWJUSU6JRWK=
SIG-M5 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHnTWM2OD1yLkKyO|I4KM7:TR?= MUfTRW5ITVJ?
NCI-H345 NGDwSmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMkO4NFUh|ryP M{nob3NCVkeHUh?=
OPM-2 NXX2eJM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMkO4PFIh|ryP M{[1cnNCVkeHUh?=
LB1047-RCC Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHflT3lKSzVyPUCuNlQ1OSEQvF2= M4HROXNCVkeHUh?=
CTB-1 NEDpfXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\FenZKSzVyPUCuNlQ1QTNizszN NWrSdodDW0GQR1XS
A3-KAW MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PPNGlEPTB;MD6yOVM1OSEQvF2= NGO3XmlUSU6JRWK=
SF126 MmHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfRUXVKSzVyPUCuNlU{QDNizszN Mn2yV2FPT0WU
KARPAS-422 NHLaOHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[1WmpKSzVyPUCuNlU1OzVizszN Ml\DV2FPT0WU
MEG-01 NXPjclVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn72TWM2OD1yLkK1Olc{KM7:TR?= MUPTRW5ITVJ?
NCI-H209 NGi3UG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvvRYNKSzVyPUCuNlY{PzRizszN MUTTRW5ITVJ?
SBC-1 NHzsd3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHlVIZQUUN3ME2wMlI3PSEQvF2= M3;WU3NCVkeHUh?=
K5 M{HifWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMk[5PFQh|ryP MkTsV2FPT0WU
QIMR-WIL M2LJNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMkexOVUh|ryP NWHBSoVUW0GQR1XS
NMC-G1 NWPRcINLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jUUWlEPTB;MD6yPFIyPyEQvF2= MkXJV2FPT0WU
IST-MES1 M4LDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzBc5RJUUN3ME2wMlI6OjN6IN88US=> MmnmV2FPT0WU
SW684 Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zVVGlEPTB;MD6zNFA1PyEQvF2= NHu1elhUSU6JRWK=
MV-4-11 NE\FdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwM{C3PFgh|ryP MojVV2FPT0WU
LAN-6 MnXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\ETWM2OD1yLkOxOVczKM7:TR?= NVXXRWVxW0GQR1XS
RH-1 NX7WNHJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwM{G4O|Eh|ryP NHTSVlhUSU6JRWK=
CP66-MEL NHPFZ|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrKS4s5UUN3ME2wMlMyQDd6IN88US=> NV7ZbVM3W0GQR1XS
EC-GI-10 NEHNeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3BN25{UUN3ME2wMlMzQTh5IN88US=> NG\TN3NUSU6JRWK=
GDM-1 NVzFbGs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPmfJhKSzVyPUCuN|MxPTlizszN MmjRV2FPT0WU
IST-SL1 NYX3XG9IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[3eW5yUUN3ME2wMlM1QTF2IN88US=> NY\LS|QyW0GQR1XS
KMOE-2 NEDsW|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYH1WHdwUUN3ME2wMlM2OTd3IN88US=> NW\pZmlVW0GQR1XS
OS-RC-2 MoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHCTWM2OD1yLkO1OVQ1KM7:TR?= MXvTRW5ITVJ?
HDLM-2 M124emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz1ZmM3UUN3ME2wMlM4QDF2IN88US=> NXPUVYhqW0GQR1XS
DSH1 MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T3NWlEPTB;MD6zPFY{OSEQvF2= NYftVYJKW0GQR1XS
LS-1034 NHzvT4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInoWFJKSzVyPUCuN|g6PTRizszN NXfLdG03W0GQR1XS
LB373-MEL-D M1zHSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDiVmhKSzVyPUCuN|kyQTdizszN M4nYenNCVkeHUh?=
GOTO MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHe3ZlhKSzVyPUCuOFIyOThizszN NV\HXZN3W0GQR1XS
MRK-nu-1 NVP0e2xmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj5NmJKSzVyPUCuOFIzODVizszN MnHXV2FPT0WU
SK-MM-2 NVPHe2lzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnDWIpGUUN3ME2wMlQ{PDR{IN88US=> M32xR3NCVkeHUh?=
BOKU NWHE[FRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvkTWM2OD1yLkSzO|kzKM7:TR?= M{T2d3NCVkeHUh?=
NOMO-1 MkHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTOTWM2OD1yLkSzPFYh|ryP MUHTRW5ITVJ?
J-RT3-T3-5 NVrxUJFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnexTWM2OD1yLkS0PFc5KM7:TR?= MoK0V2FPT0WU
COLO-668 NYn6cGJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DLWmlEPTB;MD60OVY3QCEQvF2= NU\JR2JjW0GQR1XS
SF539 NXfqO2VnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlOzTWM2OD1yLkS4Olg1KM7:TR?= M{jySXNCVkeHUh?=
LB2518-MEL NEDtU4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwNEm3NFMh|ryP MY\TRW5ITVJ?
TE-441-T M1TqUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHlTWM2OD1yLkWwNVIh|ryP NEHiN5NUSU6JRWK=
MDA-MB-134-VI MnvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTrTFJKSzVyPUCuOVA6OjFizszN MmfFV2FPT0WU
SCC-3 Mn\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLucmpIUUN3ME2wMlUyQDd|IN88US=> NVPjTXZ3W0GQR1XS
KLE M1;XZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXud3V5UUN3ME2wMlUzOTdzIN88US=> NUjUZoEyW0GQR1XS
LB2241-RCC NX7KS3ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPXcpFjUUN3ME2wMlUzPTJ3IN88US=> NHfxVWZUSU6JRWK=
NCI-H1417 NVrsRZh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;6XGw4UUN3ME2wMlU{PDN3IN88US=> MWfTRW5ITVJ?
NCI-H2081 M4fXV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi2[GhKSzVyPUCuOVg3OTFizszN NEPtbm9USU6JRWK=
NCI-H1522 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rHc2lEPTB;MD61PVM5OyEQvF2= MWPTRW5ITVJ?
NCI-H889 MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTJT4tKSzVyPUCuOVk5PDRizszN NGLvSHhUSU6JRWK=
CGTH-W-1 MlnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDETWM2OD1yLk[wO|U2KM7:TR?= MnH3V2FPT0WU
EB-3 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjhfFVHUUN3ME2wMlYyOTV|IN88US=> NIjPUYRUSU6JRWK=
D-336MG M2TmSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PoSWlEPTB;MD62NVc6OSEQvF2= MkPYV2FPT0WU
LC-1F MnHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v2VGlEPTB;MD62NlU6OiEQvF2= MWrTRW5ITVJ?
MHH-NB-11 M2PNeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\WTWM2OD1yLk[zPFAyKM7:TR?= NEXwTWhUSU6JRWK=
SK-N-FI NXXGOnF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwNkO5NUDPxE1? MnTpV2FPT0WU
NCI-H69 NX7EPZdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwNkS4O|kh|ryP MVnTRW5ITVJ?
SCH NFKzPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwNk[wNlMh|ryP NV\lSZp3W0GQR1XS
LS-513 NYqyUXB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\mWmlEPTB;MD62O|I2QSEQvF2= NVzz[oxyW0GQR1XS
CP67-MEL MnryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX35b4ZLUUN3ME2wMlY4PTl4IN88US=> MkXyV2FPT0WU
GCIY NFPtbodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1X4XWlEPTB;MD63NFM3OyEQvF2= NYS2SFJsW0GQR1XS
SHP-77 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwN{C3N|Qh|ryP Mnj1V2FPT0WU
EHEB MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G3XGlEPTB;MD63NVg2PCEQvF2= MUHTRW5ITVJ?
D-247MG NYPnSoF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwN{OyN|Ih|ryP MXXTRW5ITVJ?
Raji MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\tUWlEPTB;MD63OFk5QSEQvF2= MkLsV2FPT0WU
MPP-89 M4nUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwN{W5O|gh|ryP Ml3PV2FPT0WU
EKVX MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwN{mwO|Mh|ryP MlTxV2FPT0WU
HCC2218 M3LCPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HScmlEPTB;MD63PVE{OSEQvF2= MUTTRW5ITVJ?
KNS-81-FD Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwOEGwNVEh|ryP NH\5T5JUSU6JRWK=
HCC2157 M33IRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljSTWM2OD1yLki0PVUyKM7:TR?= M1v2S3NCVkeHUh?=
BT-474 M4f0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3uxV2lEPTB;MD64PFg2PCEQvF2= NXrJbFR5W0GQR1XS
NCI-H748 M3LCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwOUGyJO69VQ>? MoTxV2FPT0WU
EW-24 Mm\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLTS|VmUUN3ME2wMlkzODB{IN88US=> MWTTRW5ITVJ?
D-263MG NWHvZYc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\uXolHUUN3ME2wMlk1PTF{IN88US=> NW\3V4dVW0GQR1XS
OMC-1 MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkKxTWM2OD1yLkm2N|c{KM7:TR?= MknTV2FPT0WU
NCI-H2196 M{K3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTtXIRDUUN3ME2wMlk4Pzd5IN88US=> NHvofG9USU6JRWK=
HAL-01 M33yU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnXUWNKSzVyPUCuPVk5PzJizszN NVrEbI5WW0GQR1XS
NCI-H2107 M1juc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHWd3NKSzVyPUGuNFE5PTRizszN Mk\yV2FPT0WU
LB996-RCC NWXUTFFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTFwMEiwOVEh|ryP MUfTRW5ITVJ?
NCI-H1395 NUj3WVU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;Fd2VwUUN3ME2xMlExPjdizszN M3v4bnNCVkeHUh?=
CHP-126 NUmzZm5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFwMU[xPVkh|ryP MlLrV2FPT0WU
NB69 NFHne4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLUdmpxUUN3ME2xMlI3OTR6IN88US=> M3TndHNCVkeHUh?=
CAS-1 NWLhc4tvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDETWM2OD1zLkO0NlMyKM7:TR?= NF[1fo5USU6JRWK=
JVM-3 NELCe3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHMbmg4UUN3ME2xMlQ4QDV3IN88US=> Ml3nV2FPT0WU
DMS-153 NU\Vd|lyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D0bWlEPTB;MT61O|Y4PCEQvF2= M1HlVnNCVkeHUh?=
SK-MEL-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTFwN{G3PFkh|ryP NF3ydVBUSU6JRWK=
NCI-H1155 NEXZUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonBTWM2OD1zLkezOlc3KM7:TR?= NFmwOIlUSU6JRWK=
NCI-H1092 M2PJcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\TTGlEPTB;MT63OlE5OiEQvF2= M1fEUXNCVkeHUh?=
LU-165 NGLGV2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPzdFZKSzVyPUGuPFY1PzZizszN NGTtWZVUSU6JRWK=
HL-60 M3GzTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XzcmlEPTB;MT65PVkxQCEQvF2= MX;TRW5ITVJ?
REH NVjGc4N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\GdnZ2UUN3ME2yMlAxPTh{IN88US=> M4TiUnNCVkeHUh?=
JVM-2 NGr4XIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzNTJBKSzVyPUKuNFYyOzVizszN MnvoV2FPT0WU
MN-60 NYP1SllDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPSTWM2OD1{LkG3N|A5KM7:TR?= NHXh[IpUSU6JRWK=
SCC-15 NUn0NZFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJwMkCyO{DPxE1? NUTO[GFTW0GQR1XS
SNU-C1 M122Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJwMkGzOFMh|ryP MWLTRW5ITVJ?
SK-MEL-1 Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;OOWlEPTB;Mj6zNlA1PyEQvF2= MW\TRW5ITVJ?
TGW Mn3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn63TWM2OD1{LkO1NFI4KM7:TR?= NX7ScopvW0GQR1XS
CA46 NEH1ZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJwN{W5Olch|ryP M4[5R3NCVkeHUh?=
NCI-H23 NXTwfYt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTtTWM2OD1{LkiwO|kyKM7:TR?= M1u3VHNCVkeHUh?=
MMAC-SF M3vxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwOE[2Nlgh|ryP MYXTRW5ITVJ?
NCI-H2171 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XoemlEPTB;Mz6wN|Q1QCEQvF2= NHnFNmZUSU6JRWK=
A704 NVjhO2dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrKXYZDUUN3ME2zMlE1OTl2IN88US=> MULTRW5ITVJ?
DB Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7ZRYNKSzVyPUOuNlU2PzZizszN M4DDdXNCVkeHUh?=
NCI-H719 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrVfGt{UUN3ME2zMlMxOzh2IN88US=> NIPlOW9USU6JRWK=
MC-CAR M2P1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ewbGlEPTB;Mz61OFgyPyEQvF2= Mo\VV2FPT0WU
SIMA Moj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[yPWlEPTB;Mz61PFQyPiEQvF2= M3[xXHNCVkeHUh?=
SW872 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj0S|FSUUN3ME2zMlc5OTBzIN88US=> NUT0eG1jW0GQR1XS
HCC1187 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnETWM2OD1|Lke4N|E2KM7:TR?= MmLGV2FPT0WU
EW-13 NIHwUmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPMNGNKSzVyPUOuPFM1OTdizszN MorHV2FPT0WU
NCI-SNU-1 NVXZeXpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDlOmZKSzVyPUSuNlE6QTlizszN MkP0V2FPT0WU
NCI-H226 MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HHSGlEPTB;ND6zN|YxPiEQvF2= M3vHb3NCVkeHUh?=
RPMI-8866 M3rvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\sTWM2OD12LkO2NFI6KM7:TR?= M4LLXXNCVkeHUh?=
OCI-AML2 MnT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH5eGdKSzVyPUSuOVUzOyEQvF2= MU\TRW5ITVJ?
LU-65 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTRwOUOwN|Mh|ryP NEG2UXVUSU6JRWK=
SK-N-DZ MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvRW5g5UUN3ME21MlY{PDZ3IN88US=> NFPlUYtUSU6JRWK=
NB14 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rhbGlEPTB;NT65O|E{PSEQvF2= MX7TRW5ITVJ?
COLO-829 NILCTnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfFSpNmUUN3ME22MlM{OzV7IN88US=> MmD1V2FPT0WU
MHH-CALL-2 MmmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnSNlhKSzVyPU[uOVE2ODhizszN M3i1VXNCVkeHUh?=
NCI-H1770 M3\QWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HlfGlEPTB;Nj62OlkxPCEQvF2= NFzKRY5USU6JRWK=
ECC4 NY\ITlBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDwTWM2OD14LkiyNVc6KM7:TR?= M1jVWXNCVkeHUh?=
A498 MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInQXlVKSzVyPU[uPFcyQTJizszN MlfEV2FPT0WU
DMS-79 M2Lw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHnTWM2OD15LkC0OVEzKM7:TR?= NID1Z5dUSU6JRWK=
P30-OHK Ml\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTdwMkG5NFYh|ryP MV7TRW5ITVJ?
D-502MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO4TWM2OD15Lkm4N|Yh|ryP MoXNV2FPT0WU
RCC10RGB M13sTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHHPVJIUUN3ME24MlA3OjhizszN NFjzclRUSU6JRWK=
U-698-M NI[3W5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS2[lZkUUN3ME24MlI6OjJ4IN88US=> NX7UOI1jW0GQR1XS
BB49-HNC M1S5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHvfVBKSzVyPUmuOFIzPjVizszN NYDVRVR7W0GQR1XS
ES1 MofmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLmZZBKUUN3ME25MlY5QTV4IN88US=> NXr0cnhUW0GQR1XS
MFM-223 NWLlW4Z1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r5SWlEPTB;MUCuPVkzPyEQvF2= M2T1OHNCVkeHUh?=
C2BBe1 Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q2[WlEPTB;MUGuN|UzOyEQvF2= Mk[zV2FPT0WU
EB2 M2P6W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPQTWM2OD1zMj62PFgyKM7:TR?= NI\LV4JUSU6JRWK=
C8166 NH\sRpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnroTWM2OD1zMz64N|A{KM7:TR?= NWO5fm1CW0GQR1XS
ES3 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPGTItKSzVyPUGzMlk6PzdizszN MX3TRW5ITVJ?
NCI-H1650 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jmXWlEPTB;MU[uN|c3PSEQvF2= MmLNV2FPT0WU
Mo-T NU\jZ5ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXsXJlKSzVyPUG3MlQxOjlizszN M1TQVHNCVkeHUh?=
NB7 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjncVdKSzVyPUG3Mlc1PjdizszN NXK5OXY6W0GQR1XS
ES7 NGXYVIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTF7LkW1NFch|ryP MVrTRW5ITVJ?
ES5 NFS4SlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJzLke2O|Eh|ryP NGntVohUSU6JRWK=
MSTO-211H Mo\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof6TWM2OD1{MT64PFU5KM7:TR?= MlXFV2FPT0WU
U-87-MG MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fjVGlEPTB;MkWuNVk3PiEQvF2= NV7lNnNTW0GQR1XS
THP-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnGS2RKSzVyPUK5MlczODFizszN MYTTRW5ITVJ?
NB10 M17Ydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGKwb4ZKSzVyPUOwMlI3QTRizszN MnrlV2FPT0WU
NH-12 NYLsbZdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3EW4RIUUN3ME2zN{4zODF5IN88US=> NYrmWXp5W0GQR1XS
COLO-824 NID6PVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTN2LkGwNFYh|ryP MXjTRW5ITVJ?
SKM-1 M3rNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC3TWM2OD1|Nz64OFIzKM7:TR?= Ml\CV2FPT0WU
NCI-H1838 M1PqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y4emlEPTB;M{iuN|c6PyEQvF2= NFz6ToNUSU6JRWK=
RL NVv2OWh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTN7LkK0O|ch|ryP M1XlSHNCVkeHUh?=
COLO-800 M1P0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i1dWlEPTB;NECuNFc4OyEQvF2= M1H1NnNCVkeHUh?=
KG-1 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH4emJKSzVyPUSwMlg6PTVizszN NHvuWmtUSU6JRWK=
TUR MnP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\mfo5uUUN3ME20NU43Ozl7IN88US=> M1\5U3NCVkeHUh?=
LNCaP-Clone-FGC Ml;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\MTVNKSzVyPUSxMlkxOTdizszN NIrFWFdUSU6JRWK=
NCI-H322M MoD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTR{LkW5PFQh|ryP NFfrS29USU6JRWK=
LNCaP  NWrXWG9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjrN|VHUUN3ME25NU4{KG6P NVTIWotOOjV3MEWxO|Q>
C4-2 M{DIbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRThibl2= MlHPNlU2ODVzN{S=
JURKAT NVjzdVVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSxNlQhcA>? MXnJR|UxRTRzNj62OkBvVQ>? NIXKPVkzPDVzOUm5OS=>
MOLT-4 NUDENIR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[2NlQhcA>? MmHUTWM2OD1{OEWzMlUhdk1? NH\EVGozPDVzOUm5OS=>
REH MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;MZVF6OjRiaB?= MWHJR|UxRTJ6Nz62PEBvVQ>? M3HKXVI1PTF7OUm1
NALM-6 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\ydlI1KGh? MkTFTWM2OD1|NEOzNEBvVQ>? M{CxZVI1PTF7OUm1
RS 4;11 M2i1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTURmMzPCCq MojjTWM2OD13MUmuNFUhdk1? MljJNlQ2OTl7OUW=
697 MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\3eY55OjRiaB?= NWe5UFZpUUN3ME2yNVA4NjFibl2= M4nHSVI1PTF7OUm1
SIL-ALL MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELoN|AzPCCq NGKzOnhKSzVyPUG5PU44PyCwTR?= MlSwNlQ2OTl7OUW=
CEM Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLrNlQhcA>? M374PWlEPTB;NUKuNVghdk1? M4mxfVI1PTF7OUm1
P12 M4P4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\vSVI1KGh? MUHJR|UxRTN7LkK3JI5O NHiy[ZEzPDVzOUm5OS=>
NALM-16 NF6ybIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrvcoI1OjRiaB?= NEXNT4pKSzVyPUm2MlI5KG6P NU\ye2ZFOjR3MUm5PVU>
JURKAT NFS2d2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU[0PEBp NFG4VWxKSzVyPUG0Mlg1KG6P NGTEWG4zPDVzOUm5OS=>
MOLT-4 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTFOFghcA>? MWHJR|UxRTJ4Lk[gcm0> NH7YWY8zPDVzOUm5OS=>
REH MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[5[|FnPDhiaB?= NWfkS3pZUUN3ME20OE44OSCwTR?= NHXTSoUzPDVzOUm5OS=>
NALM-6 M{izVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjLOFghcA>? M2m4fWlEPTB;MkOuNlYhdk1? NYLQTXFSOjR3MUm5PVU>
RS 4;11 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzxOFghcA>? M{XzS2lEPTB;MU[0MlI5KG6P MVqyOFUyQTl7NR?=
697 NIXlVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\ZTIxSPDhiaB?= NIXJZmVKSzVyPUOwOU4{KG6P Mn\UNlQ2OTl7OUW=
SIL-ALL Mln5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUm0PEBp MUHJR|UxRTd2Lk[yJI5O NGPXNGMzPDVzOUm5OS=>
CEM NGfkVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTu[3dFPDhiaB?= NVfvUG1EUUN3ME2yOE42PSCwTR?= NFj2bXQzPDVzOUm5OS=>
P12 NX75[45qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr1fnZ4PDhiaB?= MV;JR|UxRTF6LkS2JI5O NG\CNpMzPDVzOUm5OS=>
NALM-16 NHniV2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Ly[lQ5KGh? NGe3N3pKSzVyPU[zMlI1KG6P M{nNRVI1PTF7OUm1
JURKAT Mo\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYC3NkBp NHu2SVBKSzVyPUOuOlUhdk1? NFPqdlAzPDVzOUm5OS=>
MOLT-4 NETpO3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HFTFczKGh? M3nVe2lEPTB;Nz6zPUBvVQ>? M4DF[FI1PTF7OUm1
REH M{K1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXixT3BYPzJiaB?= MUDJR|UxRTF4LkCxJI5O M4\ZblI1PTF7OUm1
NALM-6 MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vacFczKGh? NVm0cYRJUUN3ME2xMlc5KG6P MnjhNlQ2OTl7OUW=
RS 4;11 M1fG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnqeVc4OiCq NIHWXZhKSzVyPUSuN|ghdk1? MnzlNlQ2OTl7OUW=
697 M2\Cc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fmTFczKGh? NXGwUmFuUUN3ME23OE4zQCCwTR?= Mm\uNlQ2OTl7OUW=
SIL-ALL M3LsTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVK3NkBp NF7aU3JKSzVyPUeuNkBvVQ>? MlPGNlQ2OTl7OUW=
CEM M1zoU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH6O|IhcA>? NWTtToJ2UUN3ME21MlQzKG6P M4[2R|I1PTF7OUm1
P12 M{fjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDxcnFVPzJiaB?= MmDITWM2OD14LkO3JI5O NITJOY8zPDVzOUm5OS=>
NALM-16 NVvqeJoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHpO|IhcA>? MmG1TWM2OD15Nz63N{BvVQ>? NU\LUYxYOjR3MUm5PVU>
Y79 NHTZWVVCeG:ydH;zbZMhSXO|YYm= NFnydIkyNTVyIH7N M3Tz[VEzNzJ2IHi= M176e2ROW09? M{TlV4lv\HWlZXSgZZBweHSxc3nzJJdpcWOqIHPhckBj\SCnbnjhcoNm\CCkeTDIWC=> NHWxVokzPDN4Nk[2OS=>
WER-Rb-1 NEPtVYRCeG:ydH;zbZMhSXO|YYm= NHrvfW8yNTVyIH7N MkDyNVIwOjRiaB?= MnW2SG1UVw>? NGTJcYpqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ> MVKyOFM3PjZ4NR?=
G7 NG\5S3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonETWM2OD1|LkOgcm0> MUeyOFIxPDd|Mx?=
G166 NEjuSWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTdwMDDuUS=> NIG5TngzPDJyNEezNy=>
CB660 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LLVmlEPTB;Nj60JI5O NF\wfYkzPDJyNEezNy=>
CB1117 NGHqVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT5TWM2OD1zNT62JI5O M4PtPFI1OjB2N{Oz
KB-3-1 M37VSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHzfHlJUUN3ME2xMlQ5KMLzIECuOVMhdk1? MXKyN|k3OjR2NR?=
KB-8-5-11 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTVwMEGgxtEhOi5yMTDuUS=> M4rselI{QTZ{NES1
KB-C-1 NFTPdVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XudWlEPTB;MU[uO|YhyrFiND61NUBvVQ>? M2LtXVI{QTZ{NES1
KB-V-1 MnTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zLcmlEPTB;MkixMlI1KMLzIEOxMlU4KG6P MVmyN|k3OjR2NR?=
OVCAR-8 NXi2OoE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHV[IpKSzVyPUeuNVkhyrFiMz62NEBvVQ>? NGnzTVIzOzl4MkS0OS=>
NCI-ADR-RES NEHZeFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPJc|BKSzVyPUGyO|MvOzBiwsGgNVkyNjJyIH7N NUXUPJJYOjN7NkK0OFU>
MCF7 M4DMV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInadmZKSzVyPUWuNVEhyrFiMT60O{BvVQ>? NViybnZLOjN7NkK0OFU>
MCF7-FLV1000 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTN7Mz6xPEDDuSB5ND64N{BvVQ>? NUKzbFk6OjN7NkK0OFU>
S1 NVHXfWZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\rTWM2OD1{ND6zNEDDuSB2Lke1JI5O MUWyN|k3OjR2NR?=
S1-M1-80 MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLUdXJ6UUN3ME2yOlEvODZiwsGgOFgvOjVibl2= M2P1WFI{QTZ{NES1
CORL-23/P MljvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmzc|hKSzVyPUSuN|ghyrFiMT6yOUBvVQ>? NXTqTFJHOjN7NkK0OFU>
CORL-23/R MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\lUWlEPTB;NT6xOkDDuSBzLkizJI5O NX\ucnhbOjN7NkK0OFU>
NIH3T3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHYeok4UUN3ME20NE43OCEEsTC0Mlk4KG6P NGHqUYozOzl4MkS0OS=>
NIH3T3-G185 NWHnW5gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HVWmlEPTB;MkSxN{41OCEEsTC0NlMvPjZibl2= NInlRYgzOzl4MkS0OS=>
pcDNA-HEK293 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLFTWM2OD1{Lke1JOKyKDBwNkegcm0> M2K4eFI{QTZ{NES1
MDR19-HEK293 MmLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnhTZZlUUN3ME24OU42OCEEsTCxN{43PyCwTR?= MnftNlM6PjJ2NEW=
R482-HEK293 NUPSVG5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfyTWM2OD1{NT65O{DDuSB2Lkm1JI5O MV6yN|k3OjR2NR?=
MRP1-HEK293 NVTiUVV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJwOUmgxtEhOS52OTDuUS=> NUHXR5pIOjN7NkK0OFU>
SF188 NX;ucXJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH4XVVjOTBvMUCwJI5O MkT0NlQuQTZiaB?= NWHGc4R6TE2VTx?= NH3Y[ZJqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWtJIFv\CClb37j[Y51emG2aX;uMUBl\XCnZHXueEBu[W6wZYK= NFH4XWwzOzh6N{[0OS=>
T98G NFnNcolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfhR44yOC1zMECgcm0> M2ry[lI1NTl4IHi= NILlUlRFVVOR M3O4RYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHPvcoNmdnS{YYTpc44uKGSncHXk[Y51KG2jbn7ldi=> MmnnNlM5QDd4NEW=
DU145 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjQ[3VFVVOR MkOwTWM2OOLKvE[wJI5O MXiyN|g5PDR{OB?=
LNCaP  NF2zc2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlKxSG1UVw>? MX\JR|Ux6oj:N{Wgcm0> NWH2[Fd6OjN6OES0Nlg>
PC3 NF7NUnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DTWWROW09? MlPzTWM2OOLKvEG3OUBvVQ>? MXqyN|g5PDR{OB?=
RT4 M3LzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\DRpk6UUN3ME2yO{4zOSCwTR?= M3\2flI{Pzl{NkO5
5637 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLwTWM2OD12NT60O{BvVQ>? NUP1WIZ{OjN5OUK2N|k>
T24 NH\VfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTd7LkGyJI5O NWDMfZlnOjN5OUK2N|k>
MCF7  MYjGeY5kfGmxbjDBd5NigQ>? NHfr[mQyODBibl2= NHHxOWMyKGh? MXnEUXNQ M2nRTpJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZtMgS5Jm[jFuwrDT[4syNMLiUIOyMOKhW2W{cHnuZVMtKGGwZNMgW4l{eDJ? Mo\UNlM4PzB{NES=
KB-V1  MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELu[GdKSzVyPUOuPVIh|ryP MlG5NlM2QTNzOU[=
Hec50co NXyzW5FjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLkTWM2OD13IH7N MVmyN|E1PjZ6Nx?=
MDA-MB-468 NU\CcFlGSXCxcITvd4l{KEG|c3H5 NX7HUXRLOS93L{GwJI5O NXrIZnVTOjRxNEivO|IhcA>? NV\m[YhnTE2VTx?= NGD6Rm9qdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NWHheIN[OjNzNESyPVQ>
MCF10A MoTFRZBweHSxc3nzJGF{e2G7 NYPxcJpCOS93L{GwJI5O M37HXFI1NzR6L{eyJIg> MnPHSG1UVw>? M1XCeolv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M33KeVI{OTR2Mkm0
Huh-7 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O2NlEwOTBxMUCwM|ExODBibl2= MU[0PEBp NUThXlRD\GWlcnXhd4V{KHSqZTDj[YxtKH[rYXLpcIl1gSCmb4PlMYRmeGWwZHXueIx6 M{HtelIzPzR3NUi3
Daoy  NHeyVnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LmZVEvQDd3LUK0NEBvVQ>? NF\TW|Q4OiCq MUPEUXNQ MnPQTWM2OD13IH7N NEe3T2YzOjN7MEK3PS=>
ONS-76 NFvy[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPlbItIOS56N{WtNlQxKG6P NGO0cXM4OiCq NWnmWZJiTE2VTx?= NYPncolnUUN3ME23MlUhdk1? MW[yNlM6ODJ5OR?=
SUM 149 NE[5NZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLJZ5cxNTFyMDDuUS=> NXPqUZlkPzJiaB?= M3jRNIlvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> M2\ZdVIzOzB7OUO5
MDA-MB-231 NXLPVYlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7JNE0yODBibl2= NVTSTIZ7PzJiaB?= MnHmbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy NULFUHdkOjJ|MEm5N|k>
HR5 MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWSwMVExOCCwTR?= MXq3NkBp NV3ZUGducW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz MlXSNlI{ODl7M{m=
BT-474-M1 NX3hNlFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGiwOY4xNTFyMDDuUS=> NF\X[lU4OiCq M3XyU4lvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> Ml20NlI{ODl7M{m=
AU565 NVG5[oM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO3NE0yODBibl2= MmO4O|IhcA>? MX\pcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= NV\BNHFKOjJ|MEm5N|k>
T47D MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWKwMVExOCCwTR?= MnnoO|IhcA>? NHm4bZdqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> MnLYNlI{ODl7M{m=
MCF7 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m2PVAuOTByIH7N NWGyblVTPzJiaB?= MUDpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= NUPTbWc6OjJ|MEm5N|k>
HCT116p53(+/+) M3rs[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e0S|ExNTFyMECgcm0> M33XSVI1NzR6IHi= NFW2[5VqdmirYnn0d{Bk\WyuIIDyc4xq\mW{YYTpc44h[2:vcHzleIVtgSCjdDCyOUBvVQ>? MUKyNlI3OjF5MR?=
HCT116p53(-/-) MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LzSVExNTFyMECgcm0> NF;lUoIzPC92ODDo M2n2b4lvcGmkaYTzJINmdGxicILvcIln\XKjdHnvckBkd22ybHX0[Yx6KGG2IEK1JI5O M4P1OVIzOjZ{MUex
HeLa  M2TzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvnNVAuOTByIH7N MVW0PEBp NX3nNVJiTE2VTx?= NGrrdG5KSzVyPUWyMlkhdk1? M3HoRlIzODhyMkO1
HeLa  NGrpcm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHWRVcyOC1zMECgcm0> MVK3NkBp MYjEUXNQ M2nQVWlEPTB;NUCuOUBvVQ>? NFrlR4wzOjB6MEKzOS=>
GBC M1LNfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYT0OXdMPzJiaB?= M3j2eWlEPTB;MUSuO|ghdk1? NITC[lkzOTl4NUezPS=>
GB-CL-1 NILRcVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nOTVczKGh? MkfuTWM2OD13LkKyJI5O M13pT|IyQTZ3N{O5
Mz-ChA-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jYXlczKGh? MkS4TWM2OD1|LkOxJI5O MkHNNlE6PjV5M{m=
TGBC1-TKB M{KzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPvU4JYOTR2IHi= MkjzTWM2OD14LkeyJI5O MlnSNlE6PjV5M{m=
Wittier M3\Ic2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4KyUFczKGh? NVT4Vph2UUN3ME2zMlI3KG6P NXHifFM2OjF7NkW3N|k>
H-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX23NkBp NIWyVlFKSzVyPUmuOVQhdk1? M3HpSVIyQTZ3N{O5
HuH-28 NVjRTpdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPEUpViPzJiaB?= MULJR|UxRTFzLkG5JI5O NWjXfZVbOjF7NkW3N|k>
NEC M3K2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\3fGc4OiCq MYTJR|UxRTlwOUigcm0> MV2yNVk3PTd|OR?=
REB NUfGeYVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe3W5V1PzJiaB?= MkPpTWM2OD1zMz61NUBvVQ>? NH7RU|IzOTl4NUezPS=>
CC-LP-1 NXHsXXJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH6Olc4OiCq M3XWbWlEPTB;NT64OEBvVQ>? NXS2[4hMOjF7NkW3N|k>
CC-SW-1 Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17DTFczKGh? NEXDUXlKSzVyPUmuOVUhdk1? MYWyNVk3PTd|OR?=
EGI-1 MmT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofqO|IhcA>? M{i2NGlEPTB;MUCuO|Ihdk1? MWGyNVk3PTd|OR?=
Sk-ChA-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7IO|IhcA>? M3XNSGlEPTB;MUeuNkBvVQ>? NGrtNJAzOTl4NUezPS=>
TFK-1 NHXvfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzV[o53PzJiaB?= M1f4OWlEPTB;MUOuOFUhdk1? NYjsSVdkOjF7NkW3N|k>
786-O NEjtZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmO3OU05OCCwTR?= MYK5OkBp NGnLdY9JS2x? M4\nfZN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= NIn2ZnAzOTZ2MkO3OC=>
A498 NHfDZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUK1MVgxKG6P MXW5OkBp NVvWSYxPUEOu NX3yVHpbe3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N NFrPS2szOTZ2MkO3OC=>
ACHN M4XtZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGC3SFg2NThyIH7N MWq5OkBp M{X2VGhEdA>? NILF[pN{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= MVKyNVY1OjN5NB?=
Caki-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknrOU05OCCwTR?= NF;SS3I6PiCq M1\GPWhEdA>? NYXLUog3e3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N NF3TRnEzOTZ2MkO3OC=>
SN12C NWHnTZlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX21MVgxKG6P M3rodlk3KGh? NUnTRVdYUEOu MUXzeZBxemW|c3XzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXyJJdqfGhiSVO1NOKhfmGudXXzJI9nKDJidH:gNlAhdk1? NETENZMzOTZ2MkO3OC=>
HMC-1.1 MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGxMVExODBibl2= M4\yN|czKGh? NUTuWlU4cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n M2OybVIyOjR{MUi5
HMC-1.2 NFPRTpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHTNIEyNTFyMECgcm0> MYe3NkBp Mn71bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m MlviNlEzPDJzOEm=
C2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HFcFEuOTByMDDuUS=> NVnV[olJPzJiaB?= M3zSPYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\Q>? NXfmNVRLOjF{NEKxPFk>
CHP-212 NEm4WZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;peJJ6OS1zMkWgcm0> M1frZ|I1NTF{MDDo NG\NNVlqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NHr1SmUzOTF4OUK0Ni=>
IMR-32 M4jPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\QeJcyNTF{NTDuUS=> MVGyOE0yOjBiaB?= MlfobY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MXeyNVE3QTJ2Mh?=
Kelly M2LmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfmeWVnOS1zMkWgcm0> NHyyOmozPC1zMkCgbC=> MkTpbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NFjDcnYzOTF4OUK0Ni=>
SH-EP MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTaNU0yOjVibl2= NX\MW5pxOjRvMUKwJIg> NWXjdVVMcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NGXVZlYzOTF4OUK0Ni=>
SH-SY5Y M2\We2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS3NU0yOjVibl2= NWXwTnlWOjRvMUKwJIg> NG\mTZFqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NYnnfXBzOjFzNkmyOFI>
SK-N-AS NGrIcWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV6xMVEzPSCwTR?= NF;pdWQzPC1zMkCgbC=> M2DIO4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MVSyNVE3QTJ2Mh?=
SK-N-BE NVf2VY1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnDOWwyNTF{NTDuUS=> NF3iWY0zPC1zMkCgbC=> NITmWVZqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NUTJfm5YOjFzNkmyOFI>
KG1 NXmzO4dLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq1RVlUOS9zMD:xNFAhdk1? MWS3NkBp M4rOTGROW09? NGTqNplqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l M3L2ZlE6PDV6M{W4
U937 M4PYV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X0U|EwOTBxMUCwJI5O NF:1bnU4OiCq MVTEUXNQ MWTpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NGrqbm8yQTR3OEO1PC=>
CAL62 NYTzWndZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L5VlAvOS1zMECgcm0> MVq3NkBp MWDEUXNQ NH3wWo5GSzVyPUGuOEBvVQ>? NUGyZmFXOTl{MkO1OVM>
OCUT-1 NGLkNW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfTNIQxNjFvMUCwJI5O NFjUfWc4OiCq MWLEUXNQ M{nTdGVEPTB;Mj6zJI5O NU\HRlRYOTl{MkO1OVM>
8505C Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXmbmtpOC5zLUGwNEBvVQ>? MWK3NkBp MX\EUXNQ NWnpeIN3TUN3ME2zMlIhdk1? NIP4[YoyQTJ{M{W1Ny=>
ACT-1 NYn3enJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXXVlNYOC5zLUGwNEBvVQ>? NWWy[nRNPzJiaB?= NELpfHJFVVOR MkHoSWM2OD13LkSgcm0> M17FRVE6OjJ|NUWz
SW1736 NIL6eYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXiNE4yNTFyMDDuUS=> M17vOFczKGh? NGDHZ3hFVVOR MV7FR|UxRTVwNjDuUS=> NGHtU|IyQTJ{M{W1Ny=>

... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 21 mg/mL (40.25 mM)
エタノール 100 mg/mL (191.69 mM)
<1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

文献中の引用 (51)

Frequently Asked Questions

  • Question 1
    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

    Answer: For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related PLK 阻害剤

  • SBE 13 HCl

    SBE 13 HCl is a potent and selective PLK1 inhibitor with IC50 of 200 pM, >4000-fold selectivity over Aurora A kinase, Plk2 and Plk3.

  • Ro-3306

    RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with Ki of 20 nM, >15-fold selectivity against a diverse panel of human kinases.

  • CCG-1423

    CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.

  • ML141

    ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.

  • Rigosertib (ON-01910)

    Rigosertib (ON-01910)はどんな作用にPoloキナーゼ(PLK1)の非ATP競争性阻害剤、IC50が9nMになる。

  • HMN-214

    HMN-214はポロのようなキナーゼ(Plk)1への経口で強力な阻害剤で、IC50が118 nMになる。

  • GSK461364

    GSK461364はチオフェンアミド、PLK1酵素の阻害で、Kiが2 nM。[1]

    Features:Demonstrates >390-fold selectivity for Plk1 relative to Plk2 and Plk3.

  • Volasertib (BI 6727)

    Volasertib (BI 6727)は、0.87nMのIC50による非常に強力なポロのようなキナーゼ1(Plk1)阻害剤です。

    Features:A high volume of distribution, indicating good tissue penetration, and a long terminal half-life.

  • MLN0905

    MLN0905は有効的なPLK1阻害剤で、IC50が2 nMです。

最近チェックしたアイテム

Tags: BI 2536を買う | BI 2536供給者 | BI 2536を購入する | BI 2536費用 | BI 2536生産者 | オーダーBI 2536 | BI 2536代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ