BI 2536 化学構造
分子量: 521.66

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Quality Control & MSDS

製品説明

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  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 M{DIZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEC3O|Yh|ryP M3LTUHNCVkeHUh?=
ACN NF34R29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfROnBKSzVyPUCuNFA5PDNizszN MXfTRW5ITVJ?
TE-8 NF3Pc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEC5OFEh|ryP NFf0cpVUSU6JRWK=
LC-2-ad NHq4N49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnwTWM2OD1yLkCxNFk{KM7:TR?= M13WcXNCVkeHUh?=
ALL-PO M1fwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\jTWM2OD1yLkCxN{DPxE1? NF;oOGRUSU6JRWK=
EW-16 MkO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7ENYtyUUN3ME2wMlAyOzN4IN88US=> NUTVSItmW0GQR1XS
KM12 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PuPWlEPTB;MD6wNVM1QCEQvF2= NEPKNnFUSU6JRWK=
GI-1 NITESnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEGzPFMh|ryP NXLOOlk1W0GQR1XS
LS-411N NVPUcplIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXyTWM2OD1yLkCxOFA4KM7:TR?= MX;TRW5ITVJ?
ES8 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV2we2UyUUN3ME2wMlAyPDl2IN88US=> NXi1UG5mW0GQR1XS
SNU-C2B M{PIbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DpemlEPTB;MD6wNVUzPiEQvF2= MXXTRW5ITVJ?
CESS M1LpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfib3VFUUN3ME2wMlAyPjB{IN88US=> NFXPR2NUSU6JRWK=
697 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;EN2l4UUN3ME2wMlAyPjZ6IN88US=> MXXTRW5ITVJ?
NCI-H1963 NYmw[nhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfIR5dKSzVyPUCuNFE3PzNizszN NF\6TYJUSU6JRWK=
IA-LM NY[2W3hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7GXFJtUUN3ME2wMlAyPjh6IN88US=> M{\peXNCVkeHUh?=
SW954 NF\Jd2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle5TWM2OD1yLkCxO|A2KM7:TR?= M1\xT3NCVkeHUh?=
RL95-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnqTWM2OD1yLkCxO|M5KM7:TR?= M3S2O3NCVkeHUh?=
LXF-289 M3vMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LEe2lEPTB;MD6wNVc4KM7:TR?= MXHTRW5ITVJ?
OCUB-M NHPMemVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrOTWM2OD1yLkCxPFI3KM7:TR?= Mn6zV2FPT0WU
RKO MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli2TWM2OD1yLkCxPVg4KM7:TR?= NHrwZlhUSU6JRWK=
LOUCY M33nVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\iSohuUUN3ME2wMlAzODVizszN M2CxUnNCVkeHUh?=
NOS-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\2RWlEPTB;MD6wNlA6OyEQvF2= NX3BPXFjW0GQR1XS
A4-Fuk MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrPeoNKSzVyPUCuNFIzOThizszN M4fLTXNCVkeHUh?=
A388 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PUOWlEPTB;MD6wNlIzPyEQvF2= MUHTRW5ITVJ?
TE-9 NXL1Z25sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMEKyOlEh|ryP NYnKfWt3W0GQR1XS
KURAMOCHI NF\LSHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYi0cJFMUUN3ME2wMlAzOjh3IN88US=> MknSV2FPT0WU
KALS-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzjTWM2OD1yLkCyN|M5KM7:TR?= NETqcHJUSU6JRWK=
HOP-62 NX3HPYNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\zcFdKSzVyPUCuNFI1OiEQvF2= M1jLVXNCVkeHUh?=
RPMI-8402 NHzySoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn0WmtpUUN3ME2wMlAzPTB6IN88US=> NInxco9USU6JRWK=
TE-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP0ZpdNUUN3ME2wMlAzPTF{IN88US=> M3v1bHNCVkeHUh?=
CCRF-CEM M1;OXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;DWXVOUUN3ME2wMlAzPTR|IN88US=> MnL5V2FPT0WU
HUTU-80 Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\CTWM2OD1yLkCyOlI1KM7:TR?= NEP6cFdUSU6JRWK=
NCI-H1648 NYLldm1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfpTWM2OD1yLkCyOlQ4KM7:TR?= NED2R25USU6JRWK=
HCE-4 M{jGNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e4d2lEPTB;MD6wNlY5OiEQvF2= MXfTRW5ITVJ?
ETK-1 NG\0VmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjWbGhlUUN3ME2wMlAzPzN4IN88US=> M17zNXNCVkeHUh?=
TE-15 NFfQWGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:4Z|ZKSzVyPUCuNFI4OzhizszN MmfJV2FPT0WU
BE-13 NH7QOXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEK3OEDPxE1? NXnR[JE5W0GQR1XS
KE-37 NWjRfoxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEK3OFEh|ryP MWHTRW5ITVJ?
NCI-H1355 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT2TWM2OD1yLkCyO|g{KM7:TR?= MlHpV2FPT0WU
TE-11 NXf1UFRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDFTI5OUUN3ME2wMlAzQDB7IN88US=> NH3mSHVUSU6JRWK=
BL-70 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDTeVZKSzVyPUCuNFI5PTdizszN NX\PNXl6W0GQR1XS
ES6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEK4PFEh|ryP M1HPb3NCVkeHUh?=
GT3TKB MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rt[GlEPTB;MD6wNlk2OyEQvF2= MnvLV2FPT0WU
LB647-SCLC M1Hzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEOxPVUh|ryP NI\NPJFUSU6JRWK=
NB13 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r6W2lEPTB;MD6wN|MyPiEQvF2= NYDDPZFzW0GQR1XS
ST486 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi3[5Y6UUN3ME2wMlA{OzN5IN88US=> NHv1VnpUSU6JRWK=
NCI-H82 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn4dGgxUUN3ME2wMlA{OzR|IN88US=> MorlV2FPT0WU
NTERA-S-cl-D1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rLe2lEPTB;MD6wN|M6QSEQvF2= NEOyb3JUSU6JRWK=
ES4 M1XXS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEO0OlMh|ryP NFjLbZdUSU6JRWK=
SK-NEP-1 M3\2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEO0PVkh|ryP M{nEN3NCVkeHUh?=
Becker NEn6NVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1iyRWlEPTB;MD6wN|U2PSEQvF2= MWLTRW5ITVJ?
A101D MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz1TG9{UUN3ME2wMlA{PzR6IN88US=> M4DCR3NCVkeHUh?=
SK-UT-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXu1[lVvUUN3ME2wMlA{Pzd2IN88US=> M2nsUnNCVkeHUh?=
SW982 MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEO3PUDPxE1? NXvWOWF{W0GQR1XS
TE-10 NITOflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3XRmV3UUN3ME2wMlA1ODR4IN88US=> NYPh[INFW0GQR1XS
OVCAR-4 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMESwOVkh|ryP NH3EToFUSU6JRWK=
KP-N-YS MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzQTJk{UUN3ME2wMlA1ODh3IN88US=> M2\BdnNCVkeHUh?=
BL-41 NXWzWI1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjRTWM2OD1yLkC0NVI2KM7:TR?= NEfVfmZUSU6JRWK=
MZ1-PC NVi4NoFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2OzfGlEPTB;MD6wOFEzPyEQvF2= MXHTRW5ITVJ?
PF-382 NU\hUWZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMESxPVgh|ryP M13mXHNCVkeHUh?=
MOLT-13 NWXES2FUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe5cYxqUUN3ME2wMlA1OjN6IN88US=> MX\TRW5ITVJ?
HCC1599 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP3emNKSzVyPUCuNFQzPThizszN M4LrVnNCVkeHUh?=
IST-MEL1 M4\1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHNXWxKSzVyPUCuNFQ1PDJizszN MnzBV2FPT0WU
LU-139 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMES0OFIh|ryP M3XRfHNCVkeHUh?=
MS-1 MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4j5W2lEPTB;MD6wOFcxOSEQvF2= NYmyfo9HW0GQR1XS
MFH-ino M1LPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPsOWFKSzVyPUCuNFUxODNizszN MY\TRW5ITVJ?
IMR-5 NIfSc5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnITWM2OD1yLkC1NFIyKM7:TR?= MVHTRW5ITVJ?
TE-5 NYXJV2ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13KV2lEPTB;MD6wOVA3OyEQvF2= M{\WSXNCVkeHUh?=
DJM-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEWxOFIh|ryP NVnQZ|h4W0GQR1XS
NB17 Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMEWyNFch|ryP MXvTRW5ITVJ?
KARPAS-45 NIK5XmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHL[JRKSzVyPUCuNFU{PThizszN NF;kPFNUSU6JRWK=
TGBC1TKB MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXudm5KSzVyPUCuNFU1ODVizszN NUToUpN1W0GQR1XS
ML-2 Ml35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEW0NVQh|ryP M2CxOXNCVkeHUh?=
no-10 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPKTWM2OD1yLkC1OFc1KM7:TR?= NVTH[lhnW0GQR1XS
CTV-1 M2fRU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf1[HFKSzVyPUCuNFU2ODJizszN M4fG[nNCVkeHUh?=
SJSA-1 M1rJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTVSmd{UUN3ME2wMlA2PTJizszN NFW3W5hUSU6JRWK=
HC-1 NVLs[GJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTpTWM2OD1yLkC1OVk4KM7:TR?= NF\BSHFUSU6JRWK=
TE-12 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj3TWM2OD1yLkC1OlE{KM7:TR?= NU\wOYtkW0GQR1XS
KY821 MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX1XFhVUUN3ME2wMlA2PjN{IN88US=> M3;jZnNCVkeHUh?=
TALL-1 NYP5U|c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHoTXZKSzVyPUCuNFU4ODhizszN MmHKV2FPT0WU
DEL NWrJTlA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4T0d2lEPTB;MD6wOVcxQSEQvF2= MULTRW5ITVJ?
TE-6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfHZ5dKSzVyPUCuNFU4OjJizszN MVHTRW5ITVJ?
SK-LMS-1 MmfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnUbnFKSzVyPUCuNFU5ODVizszN NHjRWnRUSU6JRWK=
EW-1 NFrsUFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrCPVh4UUN3ME2wMlA2QDN5IN88US=> M4LLR3NCVkeHUh?=
8-MG-BA M3;qSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly2TWM2OD1yLkC1PFUyKM7:TR?= MlnoV2FPT0WU
NALM-6 NY\1O|JlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\C[JFKSzVyPUCuNFU6PzNizszN NEK2WXBUSU6JRWK=
LB771-HNC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHjTpZKSzVyPUCuNFU6PzlizszN NXfWRnRkW0GQR1XS
HT-144 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwME[xN{DPxE1? MlviV2FPT0WU
KM-H2 Mk\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\sUJZKSzVyPUCuNFYzOjFizszN NWPNc4p1W0GQR1XS
SF268 M4D6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjZU5h6UUN3ME2wMlA3Ojh4IN88US=> NIH5[XVUSU6JRWK=
RS4-11 Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW5WGxsUUN3ME2wMlA3OzB2IN88US=> NGn3N4dUSU6JRWK=
MHH-PREB-1 Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwME[zNVkh|ryP MWHTRW5ITVJ?
ATN-1 NV7wZ5pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwME[zOFUh|ryP NXTkOodIW0GQR1XS
BB30-HNC NXzLflhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIThXlBKSzVyPUCuNFY1OzZizszN MWHTRW5ITVJ?
CPC-N MmrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXJXVRKSzVyPUCuNFY2OjRizszN MV;TRW5ITVJ?
NB1 Mli1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DoU2lEPTB;MD6wOlYyOyEQvF2= NEHLUZpUSU6JRWK=
KS-1 NHzNNGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33mOWlEPTB;MD6wOlc1QCEQvF2= MlSwV2FPT0WU
RXF393 M2Tv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTscm9KSzVyPUCuNFY4PjRizszN Mly0V2FPT0WU
IST-SL2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4flNmlEPTB;MD6wO|AxPCEQvF2= MYXTRW5ITVJ?
GI-ME-N MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEeyPFYh|ryP MUnTRW5ITVJ?
VA-ES-BJ M1XoZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzxc4tkUUN3ME2wMlA4PDd3IN88US=> M1:0Z3NCVkeHUh?=
NCI-H1581 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEe0O|gh|ryP M4PCR3NCVkeHUh?=
U-266 NYHoWY9{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTXR5lKSzVyPUCuNFc1QTdizszN NHizZpVUSU6JRWK=
DMS-114 NGTOc21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjKUpJOUUN3ME2wMlA4PTJ6IN88US=> MU\TRW5ITVJ?
NCI-H187 NH7KfotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHoTWM2OD1yLkC3O|I3KM7:TR?= M{X1dHNCVkeHUh?=
SW962 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4C5UGlEPTB;MD6wO|g{QSEQvF2= M3\F[HNCVkeHUh?=
MONO-MAC-6 MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\GU|FYUUN3ME2wMlA4QTh4IN88US=> MV;TRW5ITVJ?
MOLT-16 NFryT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVyxV3BWUUN3ME2wMlA5OTJzIN88US=> MlPpV2FPT0WU
KNS-42 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEixOlEh|ryP NV\qOWZLW0GQR1XS
CMK M1LCNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7DTWM2OD1yLkC4NlI2KM7:TR?= MXHTRW5ITVJ?
Ramos-2G6-4C10 NEDDVVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLoTWM2OD1yLkC4NlI2KM7:TR?= MYfTRW5ITVJ?
Daudi NVjRWZBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHZTWM2OD1yLkC4NlU3KM7:TR?= NGmxSnJUSU6JRWK=
NCI-H510A NGjFZmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7zPHJmUUN3ME2wMlA5OzN4IN88US=> Ml\TV2FPT0WU
LB831-BLC M1K0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPU[nZVUUN3ME2wMlA5PTZzIN88US=> MlnSV2FPT0WU
HEL M{DMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfWdoZKSzVyPUCuNFg3PjhizszN M3uwd3NCVkeHUh?=
LU-134-A M1:xXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEi3NFgh|ryP NF[xWINUSU6JRWK=
NCI-H1694 M1jRfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPoRYpCUUN3ME2wMlA5PzR2IN88US=> M3;LTXNCVkeHUh?=
KGN M1PUbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEi3OVkh|ryP MYLTRW5ITVJ?
A253 NV63N2xUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrm[VVKSzVyPUCuNFg5OjJizszN M33oSXNCVkeHUh?=
DG-75 NYfDXW96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLzT|huUUN3ME2wMlA5QTJ{IN88US=> MY\TRW5ITVJ?
MOLT-4 M1\zS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfndpd2UUN3ME2wMlA5QTh|IN88US=> NFzjWZFUSU6JRWK=
NCI-SNU-5 Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvoRolHUUN3ME2wMlA6OjV6IN88US=> MXTTRW5ITVJ?
ONS-76 MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEmyO|Yh|ryP MmnTV2FPT0WU
NCI-H446 MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj1TWM2OD1yLkC5OFYzKM7:TR?= NYKxdVA4W0GQR1XS
COR-L279 M1\nO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnhTYU1UUN3ME2wMlA6PTV4IN88US=> NVT0R|R[W0GQR1XS
Calu-6 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV64dWI4UUN3ME2wMlA6PTl6IN88US=> NWT4VlRPW0GQR1XS
BC-3 NHrZcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M174[WlEPTB;MD6wPVY3OiEQvF2= NYK1Wm5SW0GQR1XS
NCI-H2126 NHLWTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi3T|F2UUN3ME2wMlA6PzlzIN88US=> NVvzeXdkW0GQR1XS
NCI-H1882 M334NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnJN5RNUUN3ME2wMlA6QDB7IN88US=> NGO5OHJUSU6JRWK=
BB65-RCC NH;jRVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF2xSYRKSzVyPUCuNVAzQTRizszN NGXCVHRUSU6JRWK=
DU-4475 NVrPdJBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMUC0NFch|ryP MmKyV2FPT0WU
NCI-H526 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvvTWM2OD1yLkGwOFQh|ryP M1\Bc3NCVkeHUh?=
NEC8 NEDRd3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvHOGF[UUN3ME2wMlExPTJ3IN88US=> M4Xm[nNCVkeHUh?=
NCI-H1304 NVf2SW1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHzT4k5UUN3ME2wMlExPTl2IN88US=> M3HBW3NCVkeHUh?=
L-540 NYrQRlRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zJbGlEPTB;MD6xNFcxQCEQvF2= MVvTRW5ITVJ?
NCI-SNU-16 NGHOfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zlOGlEPTB;MD6xNFc1OiEQvF2= MX\TRW5ITVJ?
HD-MY-Z NIrac5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETRfodKSzVyPUCuNVA5PTZizszN NH;iZpFUSU6JRWK=
K-562 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf5N4RnUUN3ME2wMlExQDV6IN88US=> NXPmSmZqW0GQR1XS
JAR M3fHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC2SmRKSzVyPUCuNVA6OjVizszN NXPCRpRsW0GQR1XS
MZ2-MEL NGfI[nhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HpR2lEPTB;MD6xNVA2KM7:TR?= NH[5XmpUSU6JRWK=
L-363 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPGNW9tUUN3ME2wMlEyODd7IN88US=> M1X1THNCVkeHUh?=
BV-173 NFn0OJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIKyTnpKSzVyPUCuNVEzPDNizszN M2nzZnNCVkeHUh?=
NCI-H524 NGTwUGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnruTWM2OD1yLkGxNlc1KM7:TR?= NELVOmpUSU6JRWK=
EoL-1-cell MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMUG2O|Ih|ryP Ml;PV2FPT0WU
K052 NIDrT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fYNWlEPTB;MD6xNVcyOiEQvF2= NEXYWVhUSU6JRWK=
TK10 Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH2PIJCUUN3ME2wMlEyPzJ6IN88US=> M2GyenNCVkeHUh?=
KU812 NGfQfpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\kTWlEPTB;MD6xNlA1PCEQvF2= NWHB[|JbW0GQR1XS
RPMI-8226 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3PcoRKSzVyPUCuNVIxPTJizszN MWLTRW5ITVJ?
MZ7-mel NHPRVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zte2lEPTB;MD6xNlI{PyEQvF2= MUPTRW5ITVJ?
SK-PN-DW M2O4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\3TWM2OD1yLkGyNlg4KM7:TR?= NUH1d2ZvW0GQR1XS
SR NXrldJEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnEW4JHUUN3ME2wMlEzPDRzIN88US=> MV7TRW5ITVJ?
RPMI-6666 NF;zZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;VTWM2OD1yLkGyO|Q{KM7:TR?= NIDG[WFUSU6JRWK=
no-11 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMUK4Olkh|ryP NV;ibVRWW0GQR1XS
EW-3 M4Hrdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMUK4PVMh|ryP NHPLPHVUSU6JRWK=
LAMA-84 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnVSnZZUUN3ME2wMlE{OTh5IN88US=> NYn0VIhzW0GQR1XS
HT MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMUO1O|Qh|ryP MX3TRW5ITVJ?
KP-N-RT-BM-1 NWDKd|dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMUO2NVIh|ryP MUPTRW5ITVJ?
NCI-H747 NYD4[FdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMUO3JO69VQ>? NVXR[mZVW0GQR1XS
NCCIT M4XDbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHBTWM2OD1yLkGzPVM6KM7:TR?= Ml\DV2FPT0WU
MLMA M{fPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\TTWM2OD1yLkG0NVY4KM7:TR?= NWLncnN4W0GQR1XS
LP-1 NEXX[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHGxR4pKSzVyPUCuNVQzPCEQvF2= MUfTRW5ITVJ?
CAL-148 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXOdHlzUUN3ME2wMlE1PDh|IN88US=> MlLCV2FPT0WU
GB-1 M4rVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWCwUGZ3UUN3ME2wMlE1PTJ4IN88US=> NGrSTmNUSU6JRWK=
COR-L88 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXwTWM2OD1yLkG0PFAzKM7:TR?= Mm\uV2FPT0WU
NKM-1 NHv5ZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\2TFBKSzVyPUCuNVQ6ODZizszN NGf5bHpUSU6JRWK=
NB5 MnjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMUW0OlIh|ryP MV\TRW5ITVJ?
SH-4 M3foSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHrUohrUUN3ME2wMlE2PDZ4IN88US=> MorNV2FPT0WU
EM-2 NYrVZldsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPGNmFVUUN3ME2wMlE2PDZ5IN88US=> NHW3TJJUSU6JRWK=
TGBC24TKB NVnhVpZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfNTGJKSzVyPUCuNVU3PTlizszN MnvHV2FPT0WU
SCLC-21H NH7FNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rrdWlEPTB;MD6xOVcxOiEQvF2= MXrTRW5ITVJ?
COLO-684 MlXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrPV4JKSzVyPUCuNVU4OjFizszN MWTTRW5ITVJ?
KINGS-1 MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvKT|BDUUN3ME2wMlE2QTFizszN MlrlV2FPT0WU
LS-123 NHvYPGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLOWpFKSzVyPUCuNVU6OTdizszN M1PzWXNCVkeHUh?=
MC116 MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\MT2RtUUN3ME2wMlE3OTV6IN88US=> MljCV2FPT0WU
SU-DHL-1 NFf1THhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrYZVlFUUN3ME2wMlE3OjB4IN88US=> MXTTRW5ITVJ?
NCI-H64 M2LWWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13oeGlEPTB;MD6xOlM1PyEQvF2= M2jW[HNCVkeHUh?=
HCE-T NFf1cWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvuNVVKSzVyPUCuNVY2ODRizszN M1j5T3NCVkeHUh?=
LOXIMVI NVHFUZQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMU[5OFkh|ryP M1rrXXNCVkeHUh?=
ARH-77 NUfjUZFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLYNI1pUUN3ME2wMlE4Ozd7IN88US=> NGXydnpUSU6JRWK=
DOHH-2 M2TX[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPUeVJKSzVyPUCuNVc3PzJizszN NHr5Z21USU6JRWK=
COLO-320-HSR NIf3[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jneGlEPTB;MD6xPFE2PCEQvF2= NHr1XVNUSU6JRWK=
NB6 NWj3dHdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\VTWM2OD1yLkG4OVY3KM7:TR?= NXHmPIkzW0GQR1XS
L-428 M1\5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLwTWM2OD1yLkG4PFE{KM7:TR?= MnXWV2FPT0WU
SNB75 NIX5b4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMUi4NlQh|ryP NHrXVpBUSU6JRWK=
NCI-H2141 Mn;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmewTWM2OD1yLkG5NFEyKM7:TR?= M4my[nNCVkeHUh?=
KARPAS-299 NVfwU5J7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vxbmlEPTB;MD6xPVI1OSEQvF2= MlrFV2FPT0WU
LC4-1 MnXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSwTWM2OD1yLkG5OVAzKM7:TR?= Ml3SV2FPT0WU
UACC-257 NXPmWmNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMUm5OFch|ryP MXHTRW5ITVJ?
EVSA-T M1HVfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TLNWlEPTB;MD6yNFMyOiEQvF2= M1jQVnNCVkeHUh?=
JiyoyeP-2003 M{fZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3yzc2lEPTB;MD6yNFQ4PyEQvF2= MUXTRW5ITVJ?
NCI-H720 NIPNOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMkC1NlUh|ryP MUnTRW5ITVJ?
GAK NUHPRo1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PuN2lEPTB;MD6yNVE5QSEQvF2= M1XvdnNCVkeHUh?=
HH NHz5ToVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;YPVFpUUN3ME2wMlIyPDB3IN88US=> M4LYOnNCVkeHUh?=
NCI-H1436 M{XQcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvqXJlKSzVyPUCuNlE1PjRizszN NUXvfGhlW0GQR1XS
GR-ST MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX4TWM2OD1yLkKxOFg5KM7:TR?= MX\TRW5ITVJ?
BC-1 MnXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTScphKSzVyPUCuNlI3OTZizszN MXTTRW5ITVJ?
SIG-M5 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnP2TWM2OD1yLkKyO|I4KM7:TR?= NXTiV5VWW0GQR1XS
NCI-H345 NFvOcllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmftTWM2OD1yLkKzPFA2KM7:TR?= NGHY[5NUSU6JRWK=
OPM-2 NGP4SpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7iVZg1UUN3ME2wMlI{QDh{IN88US=> MmK3V2FPT0WU
LB1047-RCC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:xTWM2OD1yLkK0OFEh|ryP NH76WlZUSU6JRWK=
CTB-1 MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTrTJY3UUN3ME2wMlI1PDl|IN88US=> Ml\RV2FPT0WU
A3-KAW M2HBcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXYTWM2OD1yLkK1N|QyKM7:TR?= M3rBW3NCVkeHUh?=
SF126 MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\Od5RKSzVyPUCuNlU{QDNizszN MmTyV2FPT0WU
KARPAS-422 NIrEXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMkW0N|Uh|ryP NHHkTIdUSU6JRWK=
MEG-01 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMkW2O|Mh|ryP M4XXPXNCVkeHUh?=
NCI-H209 NYPpSlFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzhS4VKSzVyPUCuNlY{PzRizszN NEPYWnRUSU6JRWK=
SBC-1 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrU[HZsUUN3ME2wMlI3PSEQvF2= MnT0V2FPT0WU
K5 Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXXboFKSzVyPUCuNlY6QDRizszN NVfnNlk6W0GQR1XS
QIMR-WIL MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLxdWZ6UUN3ME2wMlI4OTV3IN88US=> MlHsV2FPT0WU
NMC-G1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlywTWM2OD1yLkK4NlE4KM7:TR?= MnrOV2FPT0WU
IST-MES1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT5TWM2OD1yLkK5NlM5KM7:TR?= NXr5OncyW0GQR1XS
SW684 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTKTWM2OD1yLkOwNFQ4KM7:TR?= NGnoc45USU6JRWK=
MV-4-11 M4HHUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLKTWM2OD1yLkOwO|g5KM7:TR?= NFzqWphUSU6JRWK=
LAN-6 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml75TWM2OD1yLkOxOVczKM7:TR?= M2\0fHNCVkeHUh?=
RH-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NICwWYtKSzVyPUCuN|E5PzFizszN M1XmWHNCVkeHUh?=
CP66-MEL NGHle3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2npe2lEPTB;MD6zNVg4QCEQvF2= MljUV2FPT0WU
EC-GI-10 NXj5e3FtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXVTWM2OD1yLkOyPVg4KM7:TR?= MkKyV2FPT0WU
GDM-1 MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXqTWM2OD1yLkOzNFU6KM7:TR?= MoT3V2FPT0WU
IST-SL1 M3O5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPXbWltUUN3ME2wMlM1QTF2IN88US=> M4mzW3NCVkeHUh?=
KMOE-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi0TWM2OD1yLkO1NVc2KM7:TR?= MnfBV2FPT0WU
OS-RC-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\EU2lEPTB;MD6zOVU1PCEQvF2= MWLTRW5ITVJ?
HDLM-2 NYrGVHFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr2Z|FKSzVyPUCuN|c5OTRizszN M4X4bnNCVkeHUh?=
DSH1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwM{i2N|Eh|ryP MWLTRW5ITVJ?
LS-1034 NYXlSHV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwM{i5OVQh|ryP Ml;FV2FPT0WU
LB373-MEL-D MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XuemlEPTB;MD6zPVE6PyEQvF2= NGTvV5ZUSU6JRWK=
GOTO NIXkUY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\PemlEPTB;MD60NlEyQCEQvF2= NHjHeYZUSU6JRWK=
MRK-nu-1 NHPiXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;ROYdKSzVyPUCuOFIzODVizszN MWXTRW5ITVJ?
SK-MM-2 NHLRfoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[5eWlEPTB;MD60N|Q1OiEQvF2= NFHBSIFUSU6JRWK=
BOKU MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVraW3d2UUN3ME2wMlQ{Pzl{IN88US=> NXL4THZ1W0GQR1XS
NOMO-1 NWHxTIlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\afZRKSzVyPUCuOFM5PiEQvF2= NVPzU49nW0GQR1XS
J-RT3-T3-5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz5TWM2OD1yLkS0PFc5KM7:TR?= NGHTTXBUSU6JRWK=
COLO-668 MlHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwNEW2Olgh|ryP Mm\KV2FPT0WU
SF539 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX6TWM2OD1yLkS4Olg1KM7:TR?= NUPKTZJZW0GQR1XS
LB2518-MEL NGDtWJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTkRpRKSzVyPUCuOFk4ODNizszN Mk[wV2FPT0WU
TE-441-T M3L4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPjSllCUUN3ME2wMlUxOTJizszN NYDUeYJWW0GQR1XS
MDA-MB-134-VI M320NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPDPYZwUUN3ME2wMlUxQTJzIN88US=> NH\GSGFUSU6JRWK=
SCC-3 NYLWS2k3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHWSWFKSzVyPUCuOVE5PzNizszN NEPrb2hUSU6JRWK=
KLE NV7VbVd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwNUKxO|Eh|ryP MWjTRW5ITVJ?
LB2241-RCC M{O2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXieGFKSzVyPUCuOVI2OjVizszN MnHJV2FPT0WU
NCI-H1417 M4rsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\DTWM2OD1yLkWzOFM2KM7:TR?= MXfTRW5ITVJ?
NCI-H2081 NHvkPYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zkbWlEPTB;MD61PFYyOSEQvF2= MnfRV2FPT0WU
NCI-H1522 M4eySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnziTWM2OD1yLkW5N|g{KM7:TR?= M{DadXNCVkeHUh?=
NCI-H889 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwNUm4OFQh|ryP M1r0VXNCVkeHUh?=
CGTH-W-1 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nye2lEPTB;MD62NFc2PSEQvF2= M2jOWXNCVkeHUh?=
EB-3 M2[5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3NcFRoUUN3ME2wMlYyOTV|IN88US=> M{jnSHNCVkeHUh?=
D-336MG M{ThfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzYNmN[UUN3ME2wMlYyPzlzIN88US=> NUj5XZJEW0GQR1XS
LC-1F MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrZTWM2OD1yLk[yOVkzKM7:TR?= M4O5RXNCVkeHUh?=
MHH-NB-11 NUDBRVJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwNkO4NFEh|ryP NIPJb3VUSU6JRWK=
SK-N-FI NIDuOZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W4b2lEPTB;MD62N|kyKM7:TR?= MX7TRW5ITVJ?
NCI-H69 M2nHUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjUWYJJUUN3ME2wMlY1QDd7IN88US=> MkfWV2FPT0WU
SCH NXXCcpc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmwTWM2OD1yLk[2NFI{KM7:TR?= NEKzNJBUSU6JRWK=
LS-513 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwNkeyOVkh|ryP MYfTRW5ITVJ?
CP67-MEL NYTLSFZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLQXIdPUUN3ME2wMlY4PTl4IN88US=> M3rIc3NCVkeHUh?=
GCIY NH;lOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHvTWM2OD1yLkewN|Y{KM7:TR?= MlPHV2FPT0WU
SHP-77 NYfRWIU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK5TWM2OD1yLkewO|M1KM7:TR?= MoHzV2FPT0WU
EHEB MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjZb2ZKSzVyPUCuO|E5PTRizszN NGjZXY1USU6JRWK=
D-247MG M3rN[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILuNFhKSzVyPUCuO|MzOzJizszN MVXTRW5ITVJ?
Raji M4jmTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwN{S5PFkh|ryP NWLHS5BLW0GQR1XS
MPP-89 M4PVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXyXWl{UUN3ME2wMlc2QTd6IN88US=> MoDXV2FPT0WU
EKVX NFzqVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\uc2lEPTB;MD63PVA4OyEQvF2= Mn7rV2FPT0WU
HCC2218 NIDxb2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LxVmlEPTB;MD63PVE{OSEQvF2= MlXsV2FPT0WU
KNS-81-FD Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoroTWM2OD1yLkixNFEyKM7:TR?= M{TYT3NCVkeHUh?=
HCC2157 MoTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fRWWlEPTB;MD64OFk2OSEQvF2= NHzhVVhUSU6JRWK=
BT-474 MofUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPOeoNKSzVyPUCuPFg5PTRizszN M2G3O3NCVkeHUh?=
NCI-H748 M1nkV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fQNWlEPTB;MD65NVIh|ryP NXPjNWpIW0GQR1XS
EW-24 NWG1ZWh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwOUKwNFIh|ryP M1f2d3NCVkeHUh?=
D-263MG NUTnV2dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zPRWlEPTB;MD65OFUyOiEQvF2= M1zrXHNCVkeHUh?=
OMC-1 Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[5TWM2OD1yLkm2N|c{KM7:TR?= NF7KZ4ZUSU6JRWK=
NCI-H2196 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFr6SJNKSzVyPUCuPVc4PzdizszN MlK3V2FPT0WU
HAL-01 NUjOTWNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwOUm4O|Ih|ryP NWHEfFFtW0GQR1XS
NCI-H2107 NGK3c4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PEOmlEPTB;MT6wNVg2PCEQvF2= Moj4V2FPT0WU
LB996-RCC NHzDW3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCzSVJJUUN3ME2xMlA5ODVzIN88US=> M2XxdnNCVkeHUh?=
NCI-H1395 M2LnbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\EUGN2UUN3ME2xMlExPjdizszN NHW3OoNUSU6JRWK=
CHP-126 Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XBbGlEPTB;MT6xOlE6QSEQvF2= NXjVdnZHW0GQR1XS
NB69 NHzRR2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki0TWM2OD1zLkK2NVQ5KM7:TR?= Mke1V2FPT0WU
CAS-1 M3vrfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoKwTWM2OD1zLkO0NlMyKM7:TR?= MX3TRW5ITVJ?
JVM-3 NYjoVI9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfsUphFUUN3ME2xMlQ4QDV3IN88US=> Ml3TV2FPT0WU
DMS-153 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DUZ2lEPTB;MT61O|Y4PCEQvF2= MlzEV2FPT0WU
SK-MEL-2 M33DWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTFwN{G3PFkh|ryP M3npOnNCVkeHUh?=
NCI-H1155 M1jYU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITQd4NKSzVyPUGuO|M3PzZizszN NFLQ[25USU6JRWK=
NCI-H1092 NVHMZ414T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXGy[mlyUUN3ME2xMlc3OTh{IN88US=> MYfTRW5ITVJ?
LU-165 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTFwOE[0O|Yh|ryP M4TP[3NCVkeHUh?=
HL-60 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnK4TWM2OD1zLkm5PVA5KM7:TR?= MYHTRW5ITVJ?
REH NFv1UY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\NTWM2OD1{LkCwOVgzKM7:TR?= NFrP[YNUSU6JRWK=
JVM-2 M1\KPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13rNmlEPTB;Mj6wOlE{PSEQvF2= M{HqSXNCVkeHUh?=
MN-60 MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojyTWM2OD1{LkG3N|A5KM7:TR?= NIfa[XJUSU6JRWK=
SCC-15 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:ySXhKSzVyPUKuNlAzPyEQvF2= MlXQV2FPT0WU
SNU-C1 MnjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW2UIZ5UUN3ME2yMlIyOzR|IN88US=> MUHTRW5ITVJ?
SK-MEL-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnycWVFUUN3ME2yMlMzODR5IN88US=> MWXTRW5ITVJ?
TGW MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVm0cIRbUUN3ME2yMlM2ODJ5IN88US=> M3\FSHNCVkeHUh?=
CA46 NYn3TGV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LlZmlEPTB;Mj63OVk3PyEQvF2= MVXTRW5ITVJ?
NCI-H23 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLVTWM2OD1{LkiwO|kyKM7:TR?= MYDTRW5ITVJ?
MMAC-SF M1;6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF21d5RKSzVyPUKuPFY3OjhizszN NI\XTHlUSU6JRWK=
NCI-H2171 M1fHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DMe2lEPTB;Mz6wN|Q1QCEQvF2= NVPhclJSW0GQR1XS
A704 NFu2Z3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvuZ3NKSzVyPUOuNVQyQTRizszN NInZbVBUSU6JRWK=
DB M1LFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTNwMkW1O|Yh|ryP MlLuV2FPT0WU
NCI-H719 M4XkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS1doRKSzVyPUOuN|A{QDRizszN NIfyW3VUSU6JRWK=
MC-CAR MnPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPGTWM2OD1|LkW0PFE4KM7:TR?= MWLTRW5ITVJ?
SIMA MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNwNUi0NVYh|ryP NXzi[4d[W0GQR1XS
SW872 MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HRUmlEPTB;Mz63PFExOSEQvF2= MWTTRW5ITVJ?
HCC1187 NUDwR5BFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTNwN{izNVUh|ryP Mm\mV2FPT0WU
EW-13 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TlU2lEPTB;Mz64N|QyPyEQvF2= MXPTRW5ITVJ?
NCI-SNU-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHKTWM2OD12LkKxPVk6KM7:TR?= MmHXV2FPT0WU
NCI-H226 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVm5eJkxUUN3ME20MlM{PjB4IN88US=> NVzNN|JtW0GQR1XS
RPMI-8866 MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zjdGlEPTB;ND6zOlAzQSEQvF2= NY\wZnhwW0GQR1XS
OCI-AML2 NXLwUIFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\HeVVKSzVyPUSuOVUzOyEQvF2= MkHEV2FPT0WU
LU-65 M{TxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTRwOUOwN|Mh|ryP NXPTbGVVW0GQR1XS
SK-N-DZ NXfxTlZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M125NmlEPTB;NT62N|Q3PSEQvF2= MlLsV2FPT0WU
NB14 NXrtbo9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzobGpKSzVyPUWuPVcyOzVizszN NFKyNIFUSU6JRWK=
COLO-829 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfvfVBPUUN3ME22MlM{OzV7IN88US=> M4rLdXNCVkeHUh?=
MHH-CALL-2 NYrWdXY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\VO2lEPTB;Nj61NVUxQCEQvF2= M2TjS3NCVkeHUh?=
NCI-H1770 NYjxV|M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fDS2lEPTB;Nj62OlkxPCEQvF2= Ml[0V2FPT0WU
ECC4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvZTWM2OD14LkiyNVc6KM7:TR?= NHXxO5FUSU6JRWK=
A498 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTWTWM2OD14Lki3NVkzKM7:TR?= NEP1T2NUSU6JRWK=
DMS-79 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTdwMES1NVIh|ryP NHj5SZVUSU6JRWK=
P30-OHK MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTdwMkG5NFYh|ryP NXnEVmszW0GQR1XS
D-502MG MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TPcGlEPTB;Nz65PFM3KM7:TR?= MYrTRW5ITVJ?
RCC10RGB MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXrTWM2OD16LkC2Nlgh|ryP MkTHV2FPT0WU
U-698-M NFPae21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzLb5NKSzVyPUiuNlkzOjZizszN MWDTRW5ITVJ?
BB49-HNC NWPMdYg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\rcGpKSzVyPUmuOFIzPjVizszN MWHTRW5ITVJ?
ES1 NVHINXVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTlwNki5OVYh|ryP MUjTRW5ITVJ?
MFM-223 NITESo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjuOGd5UUN3ME2xNE46QTJ5IN88US=> MXrTRW5ITVJ?
C2BBe1 NWTURZlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\FZllKSzVyPUGxMlM2OjNizszN MojzV2FPT0WU
EB2 NVnITmtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\w[mlEPTB;MUKuOlg5OSEQvF2= MlnqV2FPT0WU
C8166 NE\oU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;RflZMUUN3ME2xN{45OzB|IN88US=> M4[wenNCVkeHUh?=
ES3 NY\Xc2pvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nUSWlEPTB;MUOuPVk4PyEQvF2= M2frNnNCVkeHUh?=
NCI-H1650 NI\QOIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnQPG5KSzVyPUG2MlM4PjVizszN M{W5RXNCVkeHUh?=
Mo-T MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDMNmpKSzVyPUG3MlQxOjlizszN M3;PXHNCVkeHUh?=
NB7 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:yTWM2OD1zNz63OFY4KM7:TR?= M1;QZnNCVkeHUh?=
ES7 MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTqZll4UUN3ME2xPU42PTB5IN88US=> NUDRbo1FW0GQR1XS
ES5 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXBUY1jUUN3ME2yNU44PjdzIN88US=> M1G2WHNCVkeHUh?=
MSTO-211H NIPlbIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJzLki4OVgh|ryP MlXzV2FPT0WU
U-87-MG NF;ldJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjUTWM2OD1{NT6xPVY3KM7:TR?= MXjTRW5ITVJ?
THP-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHuXllKSzVyPUK5MlczODFizszN NVvuSmxmW0GQR1XS
NB10 NFX1THNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HOT2lEPTB;M{CuNlY6PCEQvF2= NI\SXmRUSU6JRWK=
NH-12 NFi3Z49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTN|LkKwNVch|ryP NFrvSWhUSU6JRWK=
COLO-824 NXX4[|NQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3sUlVKSzVyPUO0MlExODZizszN M1TXT3NCVkeHUh?=
SKM-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PjZmlEPTB;M{euPFQzOiEQvF2= MU\TRW5ITVJ?
NCI-H1838 NHXmPFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljQTWM2OD1|OD6zO|k4KM7:TR?= NVXMPWE3W0GQR1XS
RL MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGKzVWVKSzVyPUO5MlI1PzdizszN MnTjV2FPT0WU
COLO-800 M3nqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOy[pRMUUN3ME20NE4xPzd|IN88US=> NIjx[YJUSU6JRWK=
KG-1 M4S0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTMc5hKSzVyPUSwMlg6PTVizszN MYnTRW5ITVJ?
TUR NWm5[GRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHP[IZKSzVyPUSxMlY{QTlizszN MkToV2FPT0WU
LNCaP-Clone-FGC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fMeWlEPTB;NEGuPVAyPyEQvF2= MUfTRW5ITVJ?
NCI-H322M NWH1V3QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\5TWM2OD12Mj61PVg1KM7:TR?= M1fKfnNCVkeHUh?=
LNCaP  MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NImwUYhKSzVyPUmxMlMhdk1? NULZVJhxOjV3MEWxO|Q>
C4-2 M4P1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRThibl2= NF2ySm4zPTVyNUG3OC=>
JURKAT MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnkSHZuOjRiaB?= M{fK[mlEPTB;NEG2MlY3KG6P M2rlNFI1PTF7OUm1
MOLT-4 M{DuUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjMb2J2OjRiaB?= M17wTWlEPTB;Mki1N{42KG6P M1voWVI1PTF7OUm1
REH Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLtNlQhcA>? NFTkTZRKSzVyPUK4O{43QCCwTR?= NHy1bY0zPDVzOUm5OS=>
NALM-6 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVKyOEBp NFjBO3hKSzVyPUO0N|MxKG6P NVLJd3NkOjR3MUm5PVU>
RS 4;11 NYPqTopHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1KwOFI1KGh? NFLjPVVKSzVyPUWxPU4xPSCwTR?= MWiyOFUyQTl7NR?=
697 NEXtT49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe5emUzPCCq NWjYNoM6UUN3ME2yNVA4NjFibl2= MljBNlQ2OTl7OUW=
SIL-ALL M1n5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz5NlQhcA>? M3nxPWlEPTB;MUm5Mlc4KG6P MmTDNlQ2OTl7OUW=
CEM MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWOwcIlSOjRiaB?= MoqzTWM2OD13Mj6xPEBvVQ>? MmfONlQ2OTl7OUW=
P12 Mly1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHIdGkzPCCq MmXuTWM2OD1|OT6yO{BvVQ>? NF7XUpMzPDVzOUm5OS=>
NALM-16 NH\6NlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUGyOEBp NICxcpVKSzVyPUm2MlI5KG6P MU[yOFUyQTl7NR?=
JURKAT NYfkZ4wzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWK0PEBp MXHJR|UxRTF2Lki0JI5O MnvsNlQ2OTl7OUW=
MOLT-4 MojES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq3PGNCPDhiaB?= M{DLWGlEPTB;Mk[uOkBvVQ>? Mk\UNlQ2OTl7OUW=
REH MoH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XBSVQ5KGh? NEDHdW5KSzVyPUS0MlcyKG6P NYTPSnlkOjR3MUm5PVU>
NALM-6 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfjbXg1QCCq MUnJR|UxRTJ|LkK2JI5O NXL1dWVlOjR3MUm5PVU>
RS 4;11 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXG1c5h3PDhiaB?= M2XtT2lEPTB;MU[0MlI5KG6P MkT5NlQ2OTl7OUW=
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SIL-ALL MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXu0PEBp NXvDb5hqUUN3ME23OE43OiCwTR?= NVPWOolYOjR3MUm5PVU>
CEM MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXW0PEBp MWDJR|UxRTJ2LkW1JI5O NY\kZ3FwOjR3MUm5PVU>
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NALM-6 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjOSVE4OiCq MkXhTWM2OD1zLke4JI5O MV6yOFUyQTl7NR?=
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SIL-ALL MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;QRXlxPzJiaB?= NUjT[4JZUUN3ME23MlIhdk1? NX3ub5BqOjR3MUm5PVU>
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G166 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TwSmlEPTB;Nz6wJI5O NXTwNGxIOjR{MES3N|M>
CB660 M33QU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHYWGxKSzVyPU[uOEBvVQ>? MYeyOFIxPDd|Mx?=
CB1117 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjkTWM2OD1zNT62JI5O NYrzSGI{OjR{MES3N|M>
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KB-8-5-11 M4GxVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36xS2lEPTB;NT6wNUDDuSB{LkCxJI5O NHHTWWQzOzl4MkS0OS=>
KB-C-1 MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHtN|lKSzVyPUG2Mlc3KMLzIESuOVEhdk1? M2XxdlI{QTZ{NES1
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OVCAR-8 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTdwMUmgxtEhOy54MDDuUS=> NYnlb5pYOjN7NkK0OFU>
NCI-ADR-RES NYDUOFNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nZTWlEPTB;MUK3N{4{OCEEsTCxPVEvOjBibl2= MofsNlM6PjJ2NEW=
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MCF7-FLV1000 NXfS[VZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGCzeHpKSzVyPUO5N{4yQCEEsTC3OE45OyCwTR?= NFfLPWkzOzl4MkS0OS=>
S1 NEn5[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TDb2lEPTB;MkSuN|AhyrFiND63OUBvVQ>? NGfxS2EzOzl4MkS0OS=>
S1-M1-80 Mn\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHFcXlrUUN3ME2yOlEvODZiwsGgOFgvOjVibl2= MlHnNlM6PjJ2NEW=
CORL-23/P MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHOfWp1UUN3ME20MlM5KMLzIEGuNlUhdk1? NW[3TXhwOjN7NkK0OFU>
CORL-23/R NF\4[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\xUWlEPTB;NT6xOkDDuSBzLkizJI5O MoPvNlM6PjJ2NEW=
NIH3T3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDlTWM2OD12MD62NEDDuSB2Lkm3JI5O MmXCNlM6PjJ2NEW=
NIH3T3-G185 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPkdpRKSzVyPUK0NVMvPDBiwsGgOFI{NjZ4IH7N NEXsSVQzOzl4MkS0OS=>
pcDNA-HEK293 Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoraTWM2OD1{Lke1JOKyKDBwNkegcm0> NV;5VYtpOjN7NkK0OFU>
MDR19-HEK293 NFn2PWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPDTWM2OD16NT61NEDDuSBzMz62O{BvVQ>? MnmxNlM6PjJ2NEW=
R482-HEK293 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjMTWM2OD1{NT65O{DDuSB2Lkm1JI5O MX:yN|k3OjR2NR?=
MRP1-HEK293 MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jKTmlEPTB;Mj65PUDDuSBzLkS5JI5O M2jVWVI{QTZ{NES1
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DU145 M3HVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGG5UZpFVVOR MknLTWM2OOLKvE[wJI5O MUmyN|g5PDR{OB?=
LNCaP  NEf1PW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrQSG1UVw>? NFzkNo5KSzVy4pk8O|Uhdk1? NH;mW|IzOzh6NESyPC=>
PC3 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTFSG1UVw>? NXfzfoptUUN3MPMIwFE4PSCwTR?= MXWyN|g5PDR{OB?=
RT4 NUixe3VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrTbWNKSzVyPUK3MlIyKG6P M376NlI{Pzl{NkO5
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MCF7  MnL5SpVv[3Srb36gRZN{[Xl? NXzrZ2NKOTByIH7N Mo\0NUBp NYDpSYUxTE2VTx?= Mn6wdoVlfWOnczD0bIUhcW6mdXP0bY9vKG:owrDHdoVjOS{EoGPnb|EtyqCSc{KsxsBU\XKyaX7hN{wh[W6mwrDXbZNxOg>? NWfSVVlzOjN5N{CyOFQ>
KB-V1  MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTNwOUKg{txO MmDiNlM2QTNzOU[=
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Daoy  Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjHb2oyNjh5NT2yOFAhdk1? NWfGe2lWPzJiaB?= MnH0SG1UVw>? M4\rOmlEPTB;NTDuUS=> MkXSNlI{QTB{N{m=
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MCF7 M3jLc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfVNE0yODBibl2= MUm3NkBp MkXjbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy NIjhN4szOjNyOUmzPS=>
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786-O MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvYO4lvPS16MDDuUS=> MXi5OkBp M3nyUmhEdA>? NGXkWFh{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= MlTFNlE3PDJ|N{S=
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Caki-1 M1\hZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj3OU05OCCwTR?= MWC5OkBp NULTR4UyUEOu M{DLS5N2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= NGrad4QzOTZ2MkO3OC=>
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HMC-1.1 NFzwRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{frNlEuOTByMDDuUS=> MUO3NkBp MUHpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> M1f1elIyOjR{MUi5
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C2 NILyN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYGxMVExODBibl2= NVq4XIRHPzJiaB?= NX;mNIJjcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n NEnyNpkzOTJ2MkG4PS=>
CHP-212 NVHzdGpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\mNU0yOjVibl2= MV6yOE0yOjBiaB?= MmmybY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NG\OcJczOTF4OUK0Ni=>
IMR-32 MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGG0OJkyNTF{NTDuUS=> MUOyOE0yOjBiaB?= MmfTbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MUKyNVE3QTJ2Mh?=
Kelly NXXrdVd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTQ[WUyNTF{NTDuUS=> MX6yOE0yOjBiaB?= NX;2b4tocW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> M4LlWlIyOTZ7MkSy
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... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 21 mg/mL (40.25 mM)
エタノール 100 mg/mL (191.69 mM)
<1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

カスタマーフィードバック (10)


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Source Cancer Cell , 2010, 18, 641–654. BI 2536 purchased from Selleck
Method Immunohistochemical analysis
Cell Lines SCID mice
Concentrations
Incubation Time
Results Control tumors grow exponentially, whereas genetic ablation of Cdc20 results in complete tumor regression in about 10 days. In comparison, treatment with taxol, vincristine, and BI2536 only induces partial responses ( Figure C). In agreement with the data observed in vitro, immunohistochemical analysis of samples taken 3 days after the first treatment indicates lack of proliferation (as measured by BrdU incorporation) and massive apoptosis in Cdc20 null cells, whereas all other samples maintain significant levels of proliferation and reduced apoptotic markers ( Figure D)

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Source Nat Cell Biol, 2011, 13, 1265-71. BI 2536 purchased from Selleck
Method cold-stable assay, Immunological methods
Cell Lines RPE1 cells
Concentrations 40 nM
Incubation Time 45 min
Results To examine whether B56-PP2A attenuates the signalling of kinetochore kinases other than Aurora B, we examined Plk1. Remarkably, wash-in of the Plk1 inhibitor BI2536 also restored K-fibres in B56-PP2A-siRNA cells.

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Western blot
Cell Lines NB TICs
Concentrations 10-100 nM
Incubation Time 16/24 h
Results The cyclin-dependent kinase inhibitor p21, a newly identified substrate of PLK1, also accumulated in BI 2536-treated NB TICs (Fig. C). Finally, PLK1 kinase activity was inhibited following treatment of NB TICs with BI 2536, as demonstrated by anti-PLK1 immunoprecipitiation followed by in vitro PLK1 kinase assay ( Fig. D)

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Trypan blue exclusion, Western blot
Cell Lines NB TICs
Concentrations 10/30/100 nmol/L
Incubation Time 24/48/72 h
Results We observed a significant difference in viable cell numbers in BI2536-treated samples, as compared with DMSO (vehicle)-treated cells, at 24 hours posttreatment. The difference became more pronounced with time, such that at 72 hours there were only approximately 20% viable cells following treatment with 10 nmol/L BI 2536 and approximately 2% to 5% viable cells following treatment with 30 and 100 nmol/L as compared with DMSO-treated cells(Fig. A). At 24 hours, BI 2536-treated cells gradually accumulated cleaved PARP, in contrast to DMSO-treated cells, suggesting induction of apoptosis ( Fig. B).

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5-25 mg/kg
Incubation Time 0-24 d
Results As shown in Figure A,tumor growth was significantly inhibited following administration of the third cycle of BI 2536 therapy. When mice were administered 25 mg/ kg weekly on 2 consecutive days for a total of only 2 cycles, tumor growth was inhibited after the second cycle ( Fig. B)

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5 mg/kg
Incubation Time 0-60 d
Results We examined a combination of a low dose of BI 2536 (12.5 mg/kg) with a low dose of irinotecan (10 mg/kg), a topoisomerase inhibitor with demonstrated activity in phase II clinical trials in relapsed NB. Single-agent treatment with low-dose of either BI 2536 or irinotecan was comparably efficacious, resulting in significant growth inhibition, as compared with vehicle-treated animals.

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Source J Invest Dermatol, 2011, 131, 1886–1895. BI 2536 purchased from Selleck
Method MTT assay
Cell Lines M14 cell lines, WM-115 cell lines
Concentrations 1-20 nM
Incubation Time
Results Specific inhibition of Plk-1 using the commercially available inhibitor BI 2536 led to a dose- and time-dependent decrease in human melanoma cell viability.

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Source J Biol Chem, 2012, 287(21), 17088-99. BI 2536 purchased from Selleck
Method Cell death assay
Cell Lines HeLa cells
Concentrations 0 -120 nM
Incubation Time 72 h
Results In HeLa cells lacking GRK5, there was an~4.5-fold decrease in the EC50 of BI 2536-mediated cell death (control shRNA, 18.9 ?.2 nM; GRK5 shRNA, 4.1?.1 nM, n = 6, p < 0.05) (Fig. A). Similar to BI 2536, cells lacking GRK5 were ~4.5-fold more sensitive to GSK461364 compared with control cells (EC50 for control shRNA cells, 17.0 ?4.4 nM;EC50 for GRK5-shRNA cells, 3.8 ?0.7 nM, n = 4, p < 0.05).

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Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 0-10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

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Rating
Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

文献中の引用 (50)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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