BI 2536

製品コードS1109

BI 2536化学構造

分子量(MW):521.66

BI2536は一種の有効なPlk1阻害剤で、無細胞試験でIC50値が0.83nMですが、Plk1に作用する選択性はPlk2とPlk3に作用する選択性より4倍と11倍がそれぞれ高くなります、臨床2期。

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文献中の引用(53)

カスタマーフィードバック(11)

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

製品安全説明書

PLK阻害剤の選択性比較

生物活性

製品説明 BI2536は一種の有効なPlk1阻害剤で、無細胞試験でIC50値が0.83nMですが、Plk1に作用する選択性はPlk2とPlk3に作用する選択性より4倍と11倍がそれぞれ高くなります、臨床2期。
特性 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
靶点
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
PI3Kα [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 2.407 μM 4.754 μM
In vitro試験

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 M1rFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3mXWdKSzVyPUCuNFA4PzZizszN MXTTRW5ITVJ?
ACN M2jSTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[wWmlEPTB;MD6wNFg1OyEQvF2= NEnlR2dUSU6JRWK=
TE-8 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjpTpRmUUN3ME2wMlAxQTRzIN88US=> M{ThRnNCVkeHUh?=
LC-2-ad NHzLVHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S1RmlEPTB;MD6wNVA6OyEQvF2= MnvwV2FPT0WU
ALL-PO NWXjeJRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ric2lEPTB;MD6wNVMh|ryP NWrZTIt{W0GQR1XS
EW-16 NHP0TFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLaTWM2OD1yLkCxN|M3KM7:TR?= M{DoR3NCVkeHUh?=
KM12 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\tRWc2UUN3ME2wMlAyOzR6IN88US=> MniwV2FPT0WU
GI-1 Mlz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEGzPFMh|ryP NF;TWINUSU6JRWK=
LS-411N NV;SfWxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFiwcXVKSzVyPUCuNFE1ODdizszN MkP5V2FPT0WU
ES8 M3nuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEG0PVQh|ryP M3vkVXNCVkeHUh?=
SNU-C2B M1e3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXzNHRUUUN3ME2wMlAyPTJ4IN88US=> NFTORo5USU6JRWK=
CESS NFrhR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEG2NFIh|ryP MnHaV2FPT0WU
697 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG0dG9KSzVyPUCuNFE3PjhizszN MWPTRW5ITVJ?
NCI-H1963 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH2OlhTUUN3ME2wMlAyPjd|IN88US=> MX7TRW5ITVJ?
IA-LM MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXyO2FKSzVyPUCuNFE3QDhizszN NGHWR2tUSU6JRWK=
SW954 NHHISWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTiZ|JDUUN3ME2wMlAyPzB3IN88US=> Mm\RV2FPT0WU
RL95-2 NFHFcXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ftVGlEPTB;MD6wNVc{QCEQvF2= M1\ZOHNCVkeHUh?=
LXF-289 M1HjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEG3O{DPxE1? MVjTRW5ITVJ?
OCUB-M MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXJTWM2OD1yLkCxPFI3KM7:TR?= M3LuXnNCVkeHUh?=
RKO MmjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\oTodUUUN3ME2wMlAyQTh5IN88US=> MkfoV2FPT0WU
LOUCY MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET6SIxKSzVyPUCuNFIxPSEQvF2= MXLTRW5ITVJ?
NOS-1 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEKwPVMh|ryP M3fKVnNCVkeHUh?=
A4-Fuk NFPCVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEKyNVgh|ryP NXzYeZVXW0GQR1XS
A388 M2P2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEKyNlch|ryP M1XZRXNCVkeHUh?=
TE-9 NGDGcIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEKyOlEh|ryP NWS2[IFsW0GQR1XS
KURAMOCHI Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\IOWlEPTB;MD6wNlI5PSEQvF2= NX3pe3lTW0GQR1XS
KALS-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O5PGlEPTB;MD6wNlM{QCEQvF2= M{exT3NCVkeHUh?=
HOP-62 M1TPNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEK0NkDPxE1? M1L5dnNCVkeHUh?=
RPMI-8402 NG\zVnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rpbWlEPTB;MD6wNlUxQCEQvF2= MoW5V2FPT0WU
TE-1 Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Twe2lEPTB;MD6wNlUyOiEQvF2= NVO0Z5VtW0GQR1XS
CCRF-CEM NVL6WFZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDlTWM2OD1yLkCyOVQ{KM7:TR?= M2rp[nNCVkeHUh?=
HUTU-80 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3jfo1KSzVyPUCuNFI3OjRizszN NV3Bd4t1W0GQR1XS
NCI-H1648 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n2TmlEPTB;MD6wNlY1PyEQvF2= M3\jfnNCVkeHUh?=
HCE-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT4VpJKSzVyPUCuNFI3QDJizszN M1jURnNCVkeHUh?=
ETK-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13NPGlEPTB;MD6wNlc{PiEQvF2= NX7DelRoW0GQR1XS
TE-15 Ml;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fWfGlEPTB;MD6wNlc{QCEQvF2= Mm\QV2FPT0WU
BE-13 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T2cGlEPTB;MD6wNlc1KM7:TR?= NV;oSpA5W0GQR1XS
KE-37 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\BNYZKSzVyPUCuNFI4PDFizszN Ml;BV2FPT0WU
NCI-H1355 M2TEVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEK3PFMh|ryP MV7TRW5ITVJ?
TE-11 NF7lVFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEK4NFkh|ryP NVzTTIJQW0GQR1XS
BL-70 M2qxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEK4OVch|ryP NYP4WFRyW0GQR1XS
ES6 MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z4[WlEPTB;MD6wNlg5OSEQvF2= Mmn2V2FPT0WU
GT3TKB MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEK5OVMh|ryP MVPTRW5ITVJ?
LB647-SCLC MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HwdGlEPTB;MD6wN|E6PSEQvF2= NVHrWI5tW0GQR1XS
NB13 Ml\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XHOmlEPTB;MD6wN|MyPiEQvF2= NVfobWtzW0GQR1XS
ST486 M1j0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjIO3VKSzVyPUCuNFM{OzdizszN Mo\BV2FPT0WU
NCI-H82 M3LMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEOzOFMh|ryP NFK2TG1USU6JRWK=
NTERA-S-cl-D1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fBO2lEPTB;MD6wN|M6QSEQvF2= NXHCZm8zW0GQR1XS
ES4 Mn21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEO0OlMh|ryP NYDibFVvW0GQR1XS
SK-NEP-1 NE[0TG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW1UIJKSzVyPUCuNFM1QTlizszN NXiydnQxW0GQR1XS
Becker NIXFNmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEO1OVUh|ryP NV3afpJGW0GQR1XS
A101D MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;IVGlEPTB;MD6wN|c1QCEQvF2= NGnIU4ZUSU6JRWK=
SK-UT-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDtdldKSzVyPUCuNFM4PzRizszN NW\OdpBwW0GQR1XS
SW982 NGP4UJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jsbWlEPTB;MD6wN|c6KM7:TR?= M3W0RnNCVkeHUh?=
TE-10 MkHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHPSlRKSzVyPUCuNFQxPDZizszN MXfTRW5ITVJ?
OVCAR-4 NIDHclVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknDTWM2OD1yLkC0NFU6KM7:TR?= NFH0V|NUSU6JRWK=
KP-N-YS MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj1fnBKSzVyPUCuNFQxQDVizszN M{DDeXNCVkeHUh?=
BL-41 NFO4WJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnqT5JpUUN3ME2wMlA1OTJ3IN88US=> M4rveXNCVkeHUh?=
MZ1-PC Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLsTWM2OD1yLkC0NVI4KM7:TR?= M{\vdXNCVkeHUh?=
PF-382 NGrq[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2SwO2lEPTB;MD6wOFE6QCEQvF2= M2CzNnNCVkeHUh?=
MOLT-13 NEm3U4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjwOmhKSzVyPUCuNFQzOzhizszN NGG4RYtUSU6JRWK=
HCC1599 MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMESyOVgh|ryP MonoV2FPT0WU
IST-MEL1 M2XXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7QfmJKSzVyPUCuNFQ1PDJizszN NHvtcJdUSU6JRWK=
LU-139 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7QTWM2OD1yLkC0OFQzKM7:TR?= NHfD[25USU6JRWK=
MS-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvhTWM2OD1yLkC0O|AyKM7:TR?= NWLafnBXW0GQR1XS
MFH-ino M{L1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[5XotKSzVyPUCuNFUxODNizszN MXfTRW5ITVJ?
IMR-5 NX\JZ2JoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XNOGlEPTB;MD6wOVAzOSEQvF2= NGHzSI1USU6JRWK=
TE-5 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn75TWM2OD1yLkC1NFY{KM7:TR?= NXvNTnV1W0GQR1XS
DJM-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEWxOFIh|ryP NWn3SppmW0GQR1XS
NB17 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEWyNFch|ryP MXzTRW5ITVJ?
KARPAS-45 NFvtRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEWzOVgh|ryP NFfrUHZUSU6JRWK=
TGBC1TKB M1H1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEW0NFUh|ryP MWTTRW5ITVJ?
ML-2 NF\ue3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3sblBkUUN3ME2wMlA2PDF2IN88US=> NW\wV|liW0GQR1XS
no-10 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMEW0O|Qh|ryP NE\aV|RUSU6JRWK=
CTV-1 NX;3TmtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEW1NFIh|ryP MoDWV2FPT0WU
SJSA-1 M37kRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXaTldKSzVyPUCuNFU2OiEQvF2= NWfNUGd4W0GQR1XS
HC-1 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTHNWxKSzVyPUCuNFU2QTdizszN MWPTRW5ITVJ?
TE-12 M4nuTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MluxTWM2OD1yLkC1OlE{KM7:TR?= MXvTRW5ITVJ?
KY821 M3X2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3joVGlEPTB;MD6wOVY{OiEQvF2= NFjkS3NUSU6JRWK=
TALL-1 NVL4WXdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELhToZKSzVyPUCuNFU4ODhizszN NEj6[|JUSU6JRWK=
DEL Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoewTWM2OD1yLkC1O|A6KM7:TR?= NXno[lhRW0GQR1XS
TE-6 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEW3NlIh|ryP NV3C[ohbW0GQR1XS
SK-LMS-1 NEjT[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnZ[XlTUUN3ME2wMlA2QDB3IN88US=> NETJN2dUSU6JRWK=
EW-1 NH\le49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnSRlBzUUN3ME2wMlA2QDN5IN88US=> NVi1VXJ[W0GQR1XS
8-MG-BA NYTFWpBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPycnFRUUN3ME2wMlA2QDVzIN88US=> MW\TRW5ITVJ?
NALM-6 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\rPGlEPTB;MD6wOVk4OyEQvF2= NXu2NGZ3W0GQR1XS
LB771-HNC NY[4[ox6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHiNVBKSzVyPUCuNFU6PzlizszN MnfqV2FPT0WU
HT-144 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmS2TWM2OD1yLkC2NVMh|ryP M2fpUnNCVkeHUh?=
KM-H2 NX3GeW54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHVTWM2OD1yLkC2NlIyKM7:TR?= NH34[oZUSU6JRWK=
SF268 MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLPSol[UUN3ME2wMlA3Ojh4IN88US=> NHqy[ppUSU6JRWK=
RS4-11 MnvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwME[zNFQh|ryP NFvF[FZUSU6JRWK=
MHH-PREB-1 NYi4ZY5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nSWGlEPTB;MD6wOlMyQSEQvF2= M3XJdnNCVkeHUh?=
ATN-1 NYP6OohRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwME[zOFUh|ryP NHvJXnhUSU6JRWK=
BB30-HNC NGrKUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGntNI9KSzVyPUCuNFY1OzZizszN NYnpUmh6W0GQR1XS
CPC-N NX6yeJlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwME[1NlQh|ryP M4HiVXNCVkeHUh?=
NB1 M2PEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz2O4pKSzVyPUCuNFY3OTNizszN MUHTRW5ITVJ?
KS-1 M4LPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwME[3OFgh|ryP M1zBXXNCVkeHUh?=
RXF393 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHZfXJUUUN3ME2wMlA3PzZ2IN88US=> M{HNfXNCVkeHUh?=
IST-SL2 NEfVb2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEewNFQh|ryP NUfubmF[W0GQR1XS
GI-ME-N MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;QTnR7UUN3ME2wMlA4Ojh4IN88US=> MmrzV2FPT0WU
VA-ES-BJ M130NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jhNmlEPTB;MD6wO|Q4PSEQvF2= NVf4TnpYW0GQR1XS
NCI-H1581 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qweGlEPTB;MD6wO|Q4QCEQvF2= Mn\xV2FPT0WU
U-266 NYTneVNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\6TWlEPTB;MD6wO|Q6PyEQvF2= Mk[5V2FPT0WU
DMS-114 NUP6TVJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEe1Nlgh|ryP Mkn5V2FPT0WU
NCI-H187 NHLDW5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq2c5p6UUN3ME2wMlA4PzJ4IN88US=> M3HaOnNCVkeHUh?=
SW962 MoGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTY[GlKSzVyPUCuNFc5OzlizszN Mm\jV2FPT0WU
MONO-MAC-6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrzSWJKSzVyPUCuNFc6QDZizszN MmrvV2FPT0WU
MOLT-16 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37qSmlEPTB;MD6wPFEzOSEQvF2= MXjTRW5ITVJ?
KNS-42 M2\BdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInLVlZKSzVyPUCuNFgyPjFizszN M{\MV3NCVkeHUh?=
CMK M1nqeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvWTWM2OD1yLkC4NlI2KM7:TR?= M2LFWnNCVkeHUh?=
Ramos-2G6-4C10 NWXpeIpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEiyNlUh|ryP NYnlS452W0GQR1XS
Daudi NITxSGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\OUnQzUUN3ME2wMlA5OjV4IN88US=> NFPhfpdUSU6JRWK=
NCI-H510A MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPoTWM2OD1yLkC4N|M3KM7:TR?= NXjSPXRTW0GQR1XS
LB831-BLC NGHvc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrFTWM2OD1yLkC4OVYyKM7:TR?= MX3TRW5ITVJ?
HEL MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVe0fIg5UUN3ME2wMlA5PjZ6IN88US=> M4TQXHNCVkeHUh?=
LU-134-A NXrHbGp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvXb3hKSzVyPUCuNFg4ODhizszN MXXTRW5ITVJ?
NCI-H1694 M{P0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;k[|l7UUN3ME2wMlA5PzR2IN88US=> NI\NUnpUSU6JRWK=
KGN MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEi3OVkh|ryP M2PR[nNCVkeHUh?=
A253 NYTHZXhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHBTWM2OD1yLkC4PFIzKM7:TR?= M1rmfHNCVkeHUh?=
DG-75 NICyfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i5cGlEPTB;MD6wPFkzOiEQvF2= NVjBSYdtW0GQR1XS
MOLT-4 MmXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm1TWM2OD1yLkC4PVg{KM7:TR?= NXzOR25nW0GQR1XS
NCI-SNU-5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;6UY5{UUN3ME2wMlA6OjV6IN88US=> NFzR[3BUSU6JRWK=
ONS-76 NWjoWFdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP6TWM2OD1yLkC5Nlc3KM7:TR?= NFLjVHFUSU6JRWK=
NCI-H446 M3q0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TLWmlEPTB;MD6wPVQ3OiEQvF2= NVfxb|k6W0GQR1XS
COR-L279 NH;IeFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH1d|cyUUN3ME2wMlA6PTV4IN88US=> MXTTRW5ITVJ?
Calu-6 NEnlN4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rqfGlEPTB;MD6wPVU6QCEQvF2= Ml\YV2FPT0WU
BC-3 M3rqSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknXTWM2OD1yLkC5OlYzKM7:TR?= NX\r[Ww{W0GQR1XS
NCI-H2126 NE\FW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDOTWM2OD1yLkC5O|kyKM7:TR?= M{LrWHNCVkeHUh?=
NCI-H1882 MoGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3GVZV5UUN3ME2wMlA6QDB7IN88US=> MVfTRW5ITVJ?
BB65-RCC NFi3Z|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTqN4ZOUUN3ME2wMlExOjl2IN88US=> M4nQOHNCVkeHUh?=
DU-4475 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PHZWlEPTB;MD6xNFQxPyEQvF2= MUTTRW5ITVJ?
NCI-H526 NYD3VVFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDHb|dXUUN3ME2wMlExPDRizszN NIDQPWpUSU6JRWK=
NEC8 NIX2bGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jKcGlEPTB;MD6xNFUzPSEQvF2= M1vNe3NCVkeHUh?=
NCI-H1304 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzNTWM2OD1yLkGwOVk1KM7:TR?= MVLTRW5ITVJ?
L-540 NFfpSVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMUC3NFgh|ryP MYHTRW5ITVJ?
NCI-SNU-16 NV7hbHUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7GcHhFUUN3ME2wMlExPzR{IN88US=> NHL1cZdUSU6JRWK=
HD-MY-Z NFX6OJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zRNmlEPTB;MD6xNFg2PiEQvF2= NGHCUHhUSU6JRWK=
K-562 M3PXPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1KxVmlEPTB;MD6xNFg2QCEQvF2= M1PtbHNCVkeHUh?=
JAR NHrJN|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nRTGlEPTB;MD6xNFkzPSEQvF2= MoXSV2FPT0WU
MZ2-MEL M4LSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3aTWM2OD1yLkGxNFUh|ryP MmXoV2FPT0WU
L-363 M{P0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMUGwO|kh|ryP M4jnenNCVkeHUh?=
BV-173 MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK2TWM2OD1yLkGxNlQ{KM7:TR?= NELVPGVUSU6JRWK=
NCI-H524 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTaZVJJUUN3ME2wMlEyOjd2IN88US=> NHy5PWVUSU6JRWK=
EoL-1-cell MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHaTWM2OD1yLkGxOlczKM7:TR?= MY\TRW5ITVJ?
K052 M{HFPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXyeJE{UUN3ME2wMlEyPzF{IN88US=> Ml7KV2FPT0WU
TK10 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PkfWlEPTB;MD6xNVczQCEQvF2= MWLTRW5ITVJ?
KU812 Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfDTWM2OD1yLkGyNFQ1KM7:TR?= MVTTRW5ITVJ?
RPMI-8226 NGDUV2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMUKwOVIh|ryP Mk\BV2FPT0WU
MZ7-mel MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMUKyN|ch|ryP NHqxVVJUSU6JRWK=
SK-PN-DW MnXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rnNGlEPTB;MD6xNlI5PyEQvF2= Mon0V2FPT0WU
SR NELnfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVqzT2lPUUN3ME2wMlEzPDRzIN88US=> M1vseXNCVkeHUh?=
RPMI-6666 M{n5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LhVmlEPTB;MD6xNlc1OyEQvF2= M4\mTXNCVkeHUh?=
no-11 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7VTWM2OD1yLkGyPFY6KM7:TR?= MVjTRW5ITVJ?
EW-3 M1XHdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMUK4PVMh|ryP MnP2V2FPT0WU
LAMA-84 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMUOxPFch|ryP Mn3qV2FPT0WU
HT NY\yW5BnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfETGlKSzVyPUCuNVM2PzRizszN Mk\qV2FPT0WU
KP-N-RT-BM-1 Mn6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr0[mRKUUN3ME2wMlE{PjF{IN88US=> MVXTRW5ITVJ?
NCI-H747 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnJ[|l6UUN3ME2wMlE{PyEQvF2= NYDGdpZlW0GQR1XS
NCCIT MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX1RlFLUUN3ME2wMlE{QTN7IN88US=> MVfTRW5ITVJ?
MLMA M1HtW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMUSxOlch|ryP M2XWTHNCVkeHUh?=
LP-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXFbHFKSzVyPUCuNVQzPCEQvF2= NISyVY9USU6JRWK=
CAL-148 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMUS0PFMh|ryP NIX5ZWRUSU6JRWK=
GB-1 M4fnb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HZemlEPTB;MD6xOFUzPiEQvF2= MnX1V2FPT0WU
COR-L88 NY\vOJhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr1TWM2OD1yLkG0PFAzKM7:TR?= NUjyXWlzW0GQR1XS
NKM-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTRcm1KSzVyPUCuNVQ6ODZizszN MX7TRW5ITVJ?
NB5 NVW1VIFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X3NGlEPTB;MD6xOVQ3OiEQvF2= MVLTRW5ITVJ?
SH-4 NEX3R2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn5TWM2OD1yLkG1OFY3KM7:TR?= Ml:wV2FPT0WU
EM-2 NFKyVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFe2UJFKSzVyPUCuNVU1PjdizszN MVvTRW5ITVJ?
TGBC24TKB NHLGcJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMUW2OVkh|ryP NHTGTnNUSU6JRWK=
SCLC-21H M4\t[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHpO4RWUUN3ME2wMlE2PzB{IN88US=> NVjKXmFGW0GQR1XS
COLO-684 NUXOV3h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMUW3NlEh|ryP NFiwfYZUSU6JRWK=
KINGS-1 NWTNXYV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMUW5NUDPxE1? MUfTRW5ITVJ?
LS-123 MoizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm5WlhKSzVyPUCuNVU6OTdizszN NXuwb242W0GQR1XS
MC116 M2jOfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUOw[Fl4UUN3ME2wMlE3OTV6IN88US=> M37GPXNCVkeHUh?=
SU-DHL-1 NGWwZYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMU[yNFYh|ryP M4jYfnNCVkeHUh?=
NCI-H64 NIDmOmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMU[zOFch|ryP MkWxV2FPT0WU
HCE-T NE\VfpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGOyc4ZKSzVyPUCuNVY2ODRizszN M{P5WnNCVkeHUh?=
LOXIMVI NIq1WHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rEcWlEPTB;MD6xOlk1QSEQvF2= MVzTRW5ITVJ?
ARH-77 M1jLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXCUI1KSzVyPUCuNVc{PzlizszN NWHRcYR{W0GQR1XS
DOHH-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fEUWlEPTB;MD6xO|Y4OiEQvF2= NXXiS4c{W0GQR1XS
COLO-320-HSR NWjwN2FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\2V5lHUUN3ME2wMlE5OTV2IN88US=> NULhenRuW0GQR1XS
NB6 NVTRboVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1e4[WlEPTB;MD6xPFU3PiEQvF2= NH\UOmxUSU6JRWK=
L-428 MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXSOpByUUN3ME2wMlE5QDF|IN88US=> MVPTRW5ITVJ?
SNB75 NU\JXppLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPqTWM2OD1yLkG4PFI1KM7:TR?= MYTTRW5ITVJ?
NCI-H2141 NEKzeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMUmwNVEh|ryP MXPTRW5ITVJ?
KARPAS-299 NX35WmtlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojhTWM2OD1yLkG5NlQyKM7:TR?= MmDCV2FPT0WU
LC4-1 M{fP[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[1VmlEPTB;MD6xPVUxOiEQvF2= MnnWV2FPT0WU
UACC-257 Mn3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXoTWM2OD1yLkG5PVQ4KM7:TR?= Mo\KV2FPT0WU
EVSA-T M3HOZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGiySYJKSzVyPUCuNlA{OTJizszN NVTF[4dyW0GQR1XS
JiyoyeP-2003 MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HlXWlEPTB;MD6yNFQ4PyEQvF2= MYHTRW5ITVJ?
NCI-H720 MlL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXITWM2OD1yLkKwOVI2KM7:TR?= MVvTRW5ITVJ?
GAK MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3oTWM2OD1yLkKxNVg6KM7:TR?= NGXuUFdUSU6JRWK=
HH NFzrS3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMkG0NFUh|ryP NIDiTGRUSU6JRWK=
NCI-H1436 M1nJO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMkG0OlQh|ryP MYTTRW5ITVJ?
GR-ST NF\ofZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzPTWM2OD1yLkKxOFg5KM7:TR?= NVi5ZnF2W0GQR1XS
BC-1 M2my[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPDTWM2OD1yLkKyOlE3KM7:TR?= NUDIb4tuW0GQR1XS
SIG-M5 NIHKUoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMkK3Nlch|ryP NXPnOoFYW0GQR1XS
NCI-H345 MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zlemlEPTB;MD6yN|gxPSEQvF2= MXnTRW5ITVJ?
OPM-2 MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q0cWlEPTB;MD6yN|g5OiEQvF2= MnnTV2FPT0WU
LB1047-RCC NFjhR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nl[mlEPTB;MD6yOFQyKM7:TR?= NE[5[o1USU6JRWK=
CTB-1 M1mycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i0WGlEPTB;MD6yOFQ6OyEQvF2= NIX4UZVUSU6JRWK=
A3-KAW MnLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXvSFdTUUN3ME2wMlI2OzRzIN88US=> NHzvZWZUSU6JRWK=
SF126 NXjKV5VbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofXTWM2OD1yLkK1N|g{KM7:TR?= MoDTV2FPT0WU
KARPAS-422 M1;OZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz3eXlKSzVyPUCuNlU1OzVizszN M2rYN3NCVkeHUh?=
MEG-01 NFS5WXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\mfGlEPTB;MD6yOVY4OyEQvF2= M17UenNCVkeHUh?=
NCI-H209 NHfKSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMk[zO|Qh|ryP M3;vS3NCVkeHUh?=
SBC-1 MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrkfXZEUUN3ME2wMlI3PSEQvF2= MUjTRW5ITVJ?
K5 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHOPGNkUUN3ME2wMlI3QTh2IN88US=> MorPV2FPT0WU
QIMR-WIL MkHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMkexOVUh|ryP M2TaW3NCVkeHUh?=
NMC-G1 NHqy[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjYTWM2OD1yLkK4NlE4KM7:TR?= NH7RO5ZUSU6JRWK=
IST-MES1 NVvpWnJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\3WWlEPTB;MD6yPVI{QCEQvF2= MnXNV2FPT0WU
SW684 M123cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;COnRKSzVyPUCuN|AxPDdizszN MXfTRW5ITVJ?
MV-4-11 MoLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD2SXlKSzVyPUCuN|A4QDhizszN MXrTRW5ITVJ?
LAN-6 NYXrdFZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvVTWM2OD1yLkOxOVczKM7:TR?= NX;sd|QxW0GQR1XS
RH-1 NWLVT4d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwM{G4O|Eh|ryP MX\TRW5ITVJ?
CP66-MEL M1\Scmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3nVmlKSzVyPUCuN|E5PzhizszN NIPRdYhUSU6JRWK=
EC-GI-10 NGPXe4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDlNlJKSzVyPUCuN|I6QDdizszN M4HBOHNCVkeHUh?=
GDM-1 NGjrWndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\5WFRKSzVyPUCuN|MxPTlizszN MnG4V2FPT0WU
IST-SL1 NU[5O|lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj6WIFuUUN3ME2wMlM1QTF2IN88US=> MknnV2FPT0WU
KMOE-2 M4D2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjNTWM2OD1yLkO1NVc2KM7:TR?= M2XW[3NCVkeHUh?=
OS-RC-2 NIXifW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPlb4RKSzVyPUCuN|U2PDRizszN MljsV2FPT0WU
HDLM-2 NULSNXFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEKxPJNKSzVyPUCuN|c5OTRizszN M4PFSnNCVkeHUh?=
DSH1 MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILPW21KSzVyPUCuN|g3OzFizszN NF\wc5VUSU6JRWK=
LS-1034 MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PqeGlEPTB;MD6zPFk2PCEQvF2= MVHTRW5ITVJ?
LB373-MEL-D NVPGWnlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH1U|NzUUN3ME2wMlM6OTl5IN88US=> NWTUd2dsW0GQR1XS
GOTO NIDPcVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwNEKxNVgh|ryP MkHSV2FPT0WU
MRK-nu-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwNEKyNFUh|ryP NVi0O25tW0GQR1XS
SK-MM-2 NFXweppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4iwOWlEPTB;MD60N|Q1OiEQvF2= NFfCOmxUSU6JRWK=
BOKU NE\CUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTs[lJrUUN3ME2wMlQ{Pzl{IN88US=> NUDNV3BwW0GQR1XS
NOMO-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2GxU2lEPTB;MD60N|g3KM7:TR?= MXfTRW5ITVJ?
J-RT3-T3-5 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[4OVZKSzVyPUCuOFQ5PzhizszN NGnDZ3BUSU6JRWK=
COLO-668 M1qwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr4XphKSzVyPUCuOFU3PjhizszN MVnTRW5ITVJ?
SF539 MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PzVWlEPTB;MD60PFY5PCEQvF2= Moi2V2FPT0WU
LB2518-MEL NHPJ[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXlTWM2OD1yLkS5O|A{KM7:TR?= NHHiPVhUSU6JRWK=
TE-441-T MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH2TWM2OD1yLkWwNVIh|ryP MWLTRW5ITVJ?
MDA-MB-134-VI NUH6O4NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInTbZpKSzVyPUCuOVA6OjFizszN MYTTRW5ITVJ?
SCC-3 MlG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHQUolCUUN3ME2wMlUyQDd|IN88US=> MYTTRW5ITVJ?
KLE MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPqOWFKSzVyPUCuOVIyPzFizszN NYTHUJA6W0GQR1XS
LB2241-RCC M1zv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwNUK1NlUh|ryP NVzqepdCW0GQR1XS
NCI-H1417 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWSzdnV7UUN3ME2wMlU{PDN3IN88US=> NVPvXVZLW0GQR1XS
NCI-H2081 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3lTWM2OD1yLkW4OlEyKM7:TR?= MX\TRW5ITVJ?
NCI-H1522 MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwNUmzPFMh|ryP M3PWVHNCVkeHUh?=
NCI-H889 NFjhRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1znVWlEPTB;MD61PVg1PCEQvF2= NEWzPYZUSU6JRWK=
CGTH-W-1 NInjdpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwNkC3OVUh|ryP MlXjV2FPT0WU
EB-3 MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LadWlEPTB;MD62NVE2OyEQvF2= MWfTRW5ITVJ?
D-336MG MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwNkG3PVEh|ryP MVjTRW5ITVJ?
LC-1F M4\xSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3z5UmlEPTB;MD62NlU6OiEQvF2= NVGxPXBXW0GQR1XS
MHH-NB-11 NVjQZXcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwNkO4NFEh|ryP MojVV2FPT0WU
SK-N-FI M3TiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonZTWM2OD1yLk[zPVEh|ryP NX22XJp4W0GQR1XS
NCI-H69 NH;iSVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3HenhKSzVyPUCuOlQ5PzlizszN NW\hR5JSW0GQR1XS
SCH NVLa[GI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i0WWlEPTB;MD62OlAzOyEQvF2= NFHPbmFUSU6JRWK=
LS-513 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwNkeyOVkh|ryP NETIenZUSU6JRWK=
CP67-MEL MmLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17xdWlEPTB;MD62O|U6PiEQvF2= MmqyV2FPT0WU
GCIY NUPROlFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\UPGlEPTB;MD63NFM3OyEQvF2= M3PSR3NCVkeHUh?=
SHP-77 NWDRXY1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwN{C3N|Qh|ryP NXPqbGhrW0GQR1XS
EHEB NFrD[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH2TWM2OD1yLkexPFU1KM7:TR?= MoDSV2FPT0WU
D-247MG Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILZUZBKSzVyPUCuO|MzOzJizszN NHXhWVNUSU6JRWK=
Raji NIe1WVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTocmJKSzVyPUCuO|Q6QDlizszN MUXTRW5ITVJ?
MPP-89 M4nUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jTdGlEPTB;MD63OVk4QCEQvF2= NXHJdppKW0GQR1XS
EKVX NYm5S5ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[4TWM2OD1yLke5NFc{KM7:TR?= M2q5XHNCVkeHUh?=
HCC2218 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnKepl{UUN3ME2wMlc6OTNzIN88US=> NFHCWYlUSU6JRWK=
KNS-81-FD M3HEWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DMcGlEPTB;MD64NVAyOSEQvF2= NHXGeZpUSU6JRWK=
HCC2157 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq0OpJKSzVyPUCuPFQ6PTFizszN MmH6V2FPT0WU
BT-474 MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXEVlRKSzVyPUCuPFg5PTRizszN NXvYOINzW0GQR1XS
NCI-H748 NXnXb2xkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrrfYpnUUN3ME2wMlkyOiEQvF2= MnLxV2FPT0WU
EW-24 Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDRRmhKSzVyPUCuPVIxODJizszN NUT2Z406W0GQR1XS
D-263MG NWH4ZZNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjaTWM2OD1yLkm0OVEzKM7:TR?= MkLqV2FPT0WU
OMC-1 M4SwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjFb3RKSzVyPUCuPVY{PzNizszN MVfTRW5ITVJ?
NCI-H2196 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYqydY9ZUUN3ME2wMlk4Pzd5IN88US=> NVzoTHBLW0GQR1XS
HAL-01 M{K2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzMTWM2OD1yLkm5PFczKM7:TR?= M{TO[nNCVkeHUh?=
NCI-H2107 MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFwMEG4OVQh|ryP NELs[JBUSU6JRWK=
LB996-RCC M3L3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHOXWFVUUN3ME2xMlA5ODVzIN88US=> M{nzdXNCVkeHUh?=
NCI-H1395 M{HCTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;TOmlEPTB;MT6xNFY4KM7:TR?= NFmxdHBUSU6JRWK=
CHP-126 NYTZ[mNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;6TWM2OD1zLkG2NVk6KM7:TR?= NXnmV4hjW0GQR1XS
NB69 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\qXW5UUUN3ME2xMlI3OTR6IN88US=> M2DmTnNCVkeHUh?=
CAS-1 NYLDU|ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vRVGlEPTB;MT6zOFI{OSEQvF2= MYHTRW5ITVJ?
JVM-3 Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDkbIhOUUN3ME2xMlQ4QDV3IN88US=> M2C2OnNCVkeHUh?=
DMS-153 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HW[WlEPTB;MT61O|Y4PCEQvF2= MVrTRW5ITVJ?
SK-MEL-2 M2e2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF74dGlKSzVyPUGuO|E4QDlizszN NUHudnN3W0GQR1XS
NCI-H1155 NE\6PGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPwNG1UUUN3ME2xMlc{Pjd4IN88US=> M3zObXNCVkeHUh?=
NCI-H1092 NHrNbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLCTWM2OD1zLke2NVgzKM7:TR?= NHPGSXJUSU6JRWK=
LU-165 M1HBZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fHdmlEPTB;MT64OlQ4PiEQvF2= NGTnOmNUSU6JRWK=
HL-60 M1yw[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW1ZY9KSzVyPUGuPVk6ODhizszN M2fnZnNCVkeHUh?=
REH NYXFcZVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Tx[mlEPTB;Mj6wNFU5OiEQvF2= M1nRXHNCVkeHUh?=
JVM-2 NGTBZ2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjGN4FKSzVyPUKuNFYyOzVizszN NUjHc2k4W0GQR1XS
MN-60 M1jKXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJwMUezNFgh|ryP NFTJVYNUSU6JRWK=
SCC-15 NU[zWFh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLBTWM2OD1{LkKwNlch|ryP MYHTRW5ITVJ?
SNU-C1 NH;3T4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmThTWM2OD1{LkKxN|Q{KM7:TR?= MUfTRW5ITVJ?
SK-MEL-1 MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\aTWM2OD1{LkOyNFQ4KM7:TR?= NFnT[mVUSU6JRWK=
TGW NGXneXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXkfW12UUN3ME2yMlM2ODJ5IN88US=> M3fYNXNCVkeHUh?=
CA46 NXHreIFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJwN{W5Olch|ryP MYPTRW5ITVJ?
NCI-H23 NHrQVI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJwOEC3PVEh|ryP MnnIV2FPT0WU
MMAC-SF NYf6dIRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvqTWM2OD1{Lki2OlI5KM7:TR?= M2LSb3NCVkeHUh?=
NCI-H2171 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTNwMEO0OFgh|ryP MnTIV2FPT0WU
A704 M2fM[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nQd2lEPTB;Mz6xOFE6PCEQvF2= MUjTRW5ITVJ?
DB M1vY[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIe3U5hKSzVyPUOuNlU2PzZizszN NELoOnVUSU6JRWK=
NCI-H719 M{H4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPMTWM2OD1|LkOwN|g1KM7:TR?= MoLFV2FPT0WU
MC-CAR NGHqTotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jiWWlEPTB;Mz61OFgyPyEQvF2= MlO4V2FPT0WU
SIMA MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn0WllbUUN3ME2zMlU5PDF4IN88US=> NH\XZ3hUSU6JRWK=
SW872 NF;OUmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PJWmlEPTB;Mz63PFExOSEQvF2= MmfvV2FPT0WU
HCC1187 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHCTWM2OD1|Lke4N|E2KM7:TR?= NUXSVndzW0GQR1XS
EW-13 M3P6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;vRXVEUUN3ME2zMlg{PDF5IN88US=> M{\2TnNCVkeHUh?=
NCI-SNU-1 NWDKblF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTU[lhKSzVyPUSuNlE6QTlizszN NHPMN3ZUSU6JRWK=
NCI-H226 NXfnV29vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLHT5BHUUN3ME20MlM{PjB4IN88US=> MXfTRW5ITVJ?
RPMI-8866 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTRwM{[wNlkh|ryP Mn7FV2FPT0WU
OCI-AML2 MmrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYSyfHJGUUN3ME20MlU2OjNizszN NF\NUpNUSU6JRWK=
LU-65 M3\3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPrWlMzUUN3ME20Mlk{ODN|IN88US=> NFKye4VUSU6JRWK=
SK-N-DZ NFPOfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3WxbGlEPTB;NT62N|Q3PSEQvF2= MVjTRW5ITVJ?
NB14 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLSTWM2OD13Lkm3NVM2KM7:TR?= MXXTRW5ITVJ?
COLO-829 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLSd413UUN3ME22MlM{OzV7IN88US=> NV\W[pg5W0GQR1XS
MHH-CALL-2 M2juVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL4TWM2OD14LkWxOVA5KM7:TR?= M12wNHNCVkeHUh?=
NCI-H1770 MmX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzifoJKSzVyPU[uOlY6ODRizszN NIfJe4JUSU6JRWK=
ECC4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTZwOEKxO|kh|ryP NUTO[XFyW0GQR1XS
A498 M{Gwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTZwOEexPVIh|ryP NGPsS4xUSU6JRWK=
DMS-79 M4Pnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1L2dWlEPTB;Nz6wOFUyOiEQvF2= MXzTRW5ITVJ?
P30-OHK M4OzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDPOY1IUUN3ME23MlIyQTB4IN88US=> NVT4SHhKW0GQR1XS
D-502MG M{PDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHIZ45bUUN3ME23Mlk5OzZizszN NXP1WHhbW0GQR1XS
RCC10RGB NH31UY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRThwME[yPEDPxE1? M3POVXNCVkeHUh?=
U-698-M MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRThwMkmyNlYh|ryP MWPTRW5ITVJ?
BB49-HNC NYS5OY9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofzTWM2OD17LkSyNlY2KM7:TR?= NHTUVJhUSU6JRWK=
ES1 NV7weGxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTlwNki5OVYh|ryP MYPTRW5ITVJ?
MFM-223 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTzOplKSzVyPUGwMlk6OjdizszN MVTTRW5ITVJ?
C2BBe1 NGXae2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\EXWlEPTB;MUGuN|UzOyEQvF2= NHXUNFRUSU6JRWK=
EB2 Mnu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF{Lk[4PFEh|ryP NH[w[IpUSU6JRWK=
C8166 NVX0SYY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYS1VnB4UUN3ME2xN{45OzB|IN88US=> M3jrNHNCVkeHUh?=
ES3 MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zHTmlEPTB;MUOuPVk4PyEQvF2= NGLndYVUSU6JRWK=
NCI-H1650 Mk\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X2OGlEPTB;MU[uN|c3PSEQvF2= NV3kfXZxW0GQR1XS
Mo-T M{DUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjIbWxJUUN3ME2xO{41ODJ7IN88US=> MUPTRW5ITVJ?
NB7 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;1d2lEPTB;MUeuO|Q3PyEQvF2= M4fHOnNCVkeHUh?=
ES7 M3\wd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnMWYpYUUN3ME2xPU42PTB5IN88US=> Mn;iV2FPT0WU
ES5 MmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLuSFVtUUN3ME2yNU44PjdzIN88US=> NFrRVIFUSU6JRWK=
MSTO-211H NH\ab4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT5TWM2OD1{MT64PFU5KM7:TR?= MUXTRW5ITVJ?
U-87-MG MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHjTWM2OD1{NT6xPVY3KM7:TR?= MX\TRW5ITVJ?
THP-1 M{XQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\iclhKSzVyPUK5MlczODFizszN NV76VXFWW0GQR1XS
NB10 MlP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPYenFKSzVyPUOwMlI3QTRizszN MWnTRW5ITVJ?
NH-12 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;ZbmU3UUN3ME2zN{4zODF5IN88US=> M4j1TXNCVkeHUh?=
COLO-824 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG3RlE2UUN3ME2zOE4yODB4IN88US=> M3Gzd3NCVkeHUh?=
SKM-1 M1\1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTN5Lki0NlIh|ryP NYfVT|M4W0GQR1XS
NCI-H1838 NG\IXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LU[2lEPTB;M{iuN|c6PyEQvF2= NYrTdnduW0GQR1XS
RL MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTN7LkK0O|ch|ryP NHSxNHBUSU6JRWK=
COLO-800 MlPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPjb3k2UUN3ME20NE4xPzd|IN88US=> MXPTRW5ITVJ?
KG-1 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PieGlEPTB;NECuPFk2PSEQvF2= M{e0SnNCVkeHUh?=
TUR M{TlfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrTTHBNUUN3ME20NU43Ozl7IN88US=> NYDGc|lsW0GQR1XS
LNCaP-Clone-FGC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7oSIJKSzVyPUSxMlkxOTdizszN NYHmUnpzW0GQR1XS
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LNCaP  MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DZfWlEPTB;OUGuN{BvVQ>? NU\iTY9FOjV3MEWxO|Q>
C4-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTmTWM2OD16IH7N NEn6U2szPTVyNUG3OC=>
JURKAT MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXWyOEBp MVrJR|UxRTRzNj62OkBvVQ>? NFW3WlEzPDVzOUm5OS=>
MOLT-4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULzNmFrOjRiaB?= NHz2flBKSzVyPUK4OVMvPSCwTR?= Mmi4NlQ2OTl7OUW=
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NALM-6 NF61ZWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWSyOEBp NWXLbIFbUUN3ME2zOFM{OCCwTR?= M4DGbFI1PTF7OUm1
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SIL-ALL MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrQdHdpOjRiaB?= MV;JR|UxRTF7OT63O{BvVQ>? NUTBb5B6OjR3MUm5PVU>
CEM M{K2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTqNlQhcA>? MWjJR|UxRTV{LkG4JI5O M4LwS|I1PTF7OUm1
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NALM-16 MlX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn6SHIzPCCq NWnYTFlpUUN3ME25Ok4zQCCwTR?= MYKyOFUyQTl7NR?=
JURKAT M1O0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H2TlQ5KGh? NYPUcJBTUUN3ME2xOE45PCCwTR?= NUfzSHRlOjR3MUm5PVU>
MOLT-4 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWGxTVFPPDhiaB?= NXfnZ2VqUUN3ME2yOk43KG6P NWLFNFl2OjR3MUm5PVU>
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NALM-6 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj4OFghcA>? MYrJR|UxRTJ|LkK2JI5O NULsWG06OjR3MUm5PVU>
RS 4;11 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoexOFghcA>? M2r3bWlEPTB;MU[0MlI5KG6P M{POXlI1PTF7OUm1
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SIL-ALL MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWS0PEBp MojSTWM2OD15ND62NkBvVQ>? NFXpO4szPDVzOUm5OS=>
CEM NUT1fJROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfSVXZPPDhiaB?= NVq2Xmk1UUN3ME2yOE42PSCwTR?= NVjQWWVzOjR3MUm5PVU>
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NALM-16 M3P0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ixT|Q5KGh? MnXzTWM2OD14Mz6yOEBvVQ>? MmK4NlQ2OTl7OUW=
JURKAT M2nBRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi5PXc1PzJiaB?= MXrJR|UxRTNwNkWgcm0> Ml:2NlQ2OTl7OUW=
MOLT-4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HYZ|czKGh? M4PVWmlEPTB;Nz6zPUBvVQ>? MlG5NlQ2OTl7OUW=
REH MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3wbZYzPzJiaB?= MmG4TWM2OD1zNj6wNUBvVQ>? NXq3UIVuOjR3MUm5PVU>
NALM-6 NFX3[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO5R5U4OiCq MVPJR|UxRTFwN{igcm0> Moi5NlQ2OTl7OUW=
RS 4;11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjkVZE4OiCq NWnmXJFHUUN3ME20MlM5KG6P MmDoNlQ2OTl7OUW=
697 M3LPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjoO|IhcA>? MXHJR|UxRTd2LkK4JI5O M1vk[lI1PTF7OUm1
SIL-ALL MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYm3NkBp NYC1PGhvUUN3ME23MlIhdk1? MVeyOFUyQTl7NR?=
CEM MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWOzVopGPzJiaB?= NIT5UHZKSzVyPUWuOFIhdk1? M4K3XVI1PTF7OUm1
P12 NVfMeVVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrnfXA4OiCq NFvvTHhKSzVyPU[uN|chdk1? NVXQe4EyOjR3MUm5PVU>
NALM-16 NV\OVW45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfXdYQ4OiCq MUXJR|UxRTd5LkezJI5O NXzwZmU1OjR3MUm5PVU>
Y79 M2LwOGFxd3C2b4Ppd{BCe3OjeR?= MUKxMVUxKG6P NISybIYyOi9{NDDo MnfzSG1UVw>? NEe1e5VqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ> NVv1SJpbOjR|Nk[2OlU>
WER-Rb-1 NUPMOoJoSXCxcITvd4l{KEG|c3H5 NYjYd5lyOS13MDDuUS=> M1jiRVEzNzJ2IHi= NVfZW2RGTE2VTx?= NWrLWlBlcW6mdXPl[EBieG:ydH;zbZMhf2irY3igZ4FvKGKnIHXubIFv[2WmIHL5JGhV M3TDVlI1OzZ4Nk[1
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G166 NUXhfIhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTdwMDDuUS=> NGXIfGEzPDJyNEezNy=>
CB660 NHL3eJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rrcGlEPTB;Nj60JI5O M1\rb|I1OjB2N{Oz
CB1117 Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XvU2lEPTB;MUWuOkBvVQ>? MUWyOFIxPDd|Mx?=
KB-3-1 NVrLWmxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[zTWM2OD1zLkS4JOKyKDBwNUOgcm0> MX[yN|k3OjR2NR?=
KB-8-5-11 NInUR4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[wRWR6UUN3ME21MlAyKMLzIEKuNFEhdk1? M4nTflI{QTZ{NES1
KB-C-1 MoW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF4Lke2JOKyKDRwNUGgcm0> M3XNTFI{QTZ{NES1
KB-V-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTlTnlUUUN3ME2yPFEvOjRiwsGgN|EvPTdibl2= M323OFI{QTZ{NES1
OVCAR-8 M33NNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjFV3BKSzVyPUeuNVkhyrFiMz62NEBvVQ>? NU\GcYt{OjN7NkK0OFU>
NCI-ADR-RES NWj5fINNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLibVlKSzVyPUGyO|MvOzBiwsGgNVkyNjJyIH7N MUGyN|k3OjR2NR?=
MCF7 M2\2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTVwMUGgxtEhOS52NzDuUS=> MYKyN|k3OjR2NR?=
MCF7-FLV1000 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vyXWlEPTB;M{mzMlE5KMLzIEe0Mlg{KG6P MlvVNlM6PjJ2NEW=
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S1-M1-80 NHq0RppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJ4MT6wOkDDuSB2OD6yOUBvVQ>? M3j5U|I{QTZ{NES1
CORL-23/P M{j6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTRwM{igxtEhOS5{NTDuUS=> NYPZVYNqOjN7NkK0OFU>
CORL-23/R M3fYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXiwR243UUN3ME21MlE3KMLzIEGuPFMhdk1? NHm4c5IzOzl4MkS0OS=>
NIH3T3 NYHYZ4ppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTRyLk[wJOKyKDRwOUegcm0> MlfsNlM6PjJ2NEW=
NIH3T3-G185 MmfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTzWY9IUUN3ME2yOFE{NjRyINMxJFQzOy54NjDuUS=> NWnYPGNpOjN7NkK0OFU>
pcDNA-HEK293 M4H5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPXeottUUN3ME2yMlc2KMLzIECuOlchdk1? NIP3cWUzOzl4MkS0OS=>
MDR19-HEK293 M3vpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XaXGlEPTB;OEWuOVAhyrFiMUOuOlchdk1? MWCyN|k3OjR2NR?=
R482-HEK293 NIfGT2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;ENItLUUN3ME2yOU46PyEEsTC0Mlk2KG6P NVe3SpU1OjN7NkK0OFU>
MRP1-HEK293 NWS0R48yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYewTWJGUUN3ME2yMlk6KMLzIEGuOFkhdk1? MkDUNlM6PjJ2NEW=
SF188 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYOxNE0yODBibl2= MoCxNlQuQTZiaB?= NXS4N4tbTE2VTx?= MVXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWVvIHHu[EBkd26lZX70doF1cW:wLTDk[ZBm\GWwdDDtZY5v\XJ? NHOycnMzOzh6N{[0OS=>
T98G Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPRRo4yOC1zMECgcm0> MUGyOE06PiCq NXrUVY41TE2VTx?= MmrDbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy NYPrdJFNOjN6OEe2OFU>
DU145 NIX0Vo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPHW3VETE2VTx?= NH7kSpFKSzVy4pk8OlAhdk1? NXn4emFYOjN6OES0Nlg>
LNCaP  M4HhWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\JR2ROW09? MWfJR|Ux6oj:N{Wgcm0> M2rORVI{QDh2NEK4
PC3 NFexXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H0d2ROW09? MXHJR|Ux6oj:MUe1JI5O M4HHSFI{QDh2NEK4
RT4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS0TXNKSzVyPUK3MlIyKG6P MoHtNlM4QTJ4M{m=
5637 NHn1VpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TNfmlEPTB;NEWuOFchdk1? Mlf3NlM4QTJ4M{m=
T24 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzneXVQUUN3ME23PU4yOiCwTR?= MoS2NlM4QTJ4M{m=
MCF7  M2XXRWZ2dmO2aX;uJGF{e2G7 NWXZeZl7OTByIH7N NF7OVnkyKGh? MX7EUXNQ NVXNeXhNemWmdXPld{B1cGViaX7keYN1cW:wIH;mxsBIemWkMT|CpHNoczFuwrDQd|ItyqCVZYLwbY5iOyxiYX7kxsBYcXOyMh?= NH7zNJozOzd5MEK0OC=>
KB-V1  MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTNwOUKg{txO MY[yN|U6OzF7Nh?=
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MDA-MB-468 NH7ab2lCeG:ydH;zbZMhSXO|YYm= MmjINU82NzFyIH7N NIPjXFQzPC92OD:3NkBp MXTEUXNQ NG\tbVRqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MXqyN|E1PDJ7NB?=
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ONS-76 NV7FWHlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX2xMlg4PS1{NECgcm0> NXHBWpRzPzJiaB?= NWDkTZFxTE2VTx?= MV\JR|UxRTdwNTDuUS=> NVjtSVkxOjJ|OUCyO|k>
SUM 149 M2fpN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPwR3kxNTFyMDDuUS=> MofCO|IhcA>? NUDTO|BFcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz NX7JcZFoOjJ|MEm5N|k>
MDA-MB-231 NVu0TlR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS2NE0yODBibl2= MmfDO|IhcA>? NYHobHh5cW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz NUf3S3hZOjJ|MEm5N|k>
HR5 MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPZ[nh4OC1zMECgcm0> NX71dFFQPzJiaB?= NHrFR3lqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> MXeyNlMxQTl|OR?=
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Wittier NX7TRmhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonJO|IhcA>? MY\JR|UxRTNwMk[gcm0> MY[yNVk3PTd|OR?=
H-1 NYDrSIIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLRO|IhcA>? NXnZOIo2UUN3ME25MlU1KG6P NViycnFLOjF7NkW3N|k>
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EGI-1 M2PaRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV63NkBp NY\mdWlrUUN3ME2xNE44OiCwTR?= NH3DcJYzOTl4NUezPS=>
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TFK-1 Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDGO|IhcA>? M1TSUmlEPTB;MUOuOFUhdk1? MYCyNVk3PTd|OR?=
786-O MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTkUZZRPS16MDDuUS=> M1jMfFk3KGh? MnXNTGNt NGfUd|F{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= MmHUNlE3PDJ|N{S=
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ACHN MmLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;Vc|UuQDBibl2= M3Lk[lk3KGh? M1;XTWhEdA>? NG\GdVV{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= NUj2Z2hpOjF4NEKzO|Q>
Caki-1 M3TiUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7vOU05OCCwTR?= MkW3PVYhcA>? NXnOfoNmUEOu NHHZe3J{fXCycnXzd4V{KHSqZTDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVzKHerdHigTWM2OMLidnHseYV{KG:oIEKgeI8hOjBibl2= NU\sSI15OjF4NEKzO|Q>
SN12C MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX2ycVZVPS16MDDuUS=> MUG5OkBp M4rIbWhEdA>? M1PQd5N2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= M33rbFIyPjR{M{e0
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C2 M4r4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXKxMVExODBibl2= MmK1O|IhcA>? MnP0bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m NX7mZW03OjF{NEKxPFk>
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SW1736 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfY[XoxNjFvMUCwJI5O MmCxO|IhcA>? NFTjVIVFVVOR M4HIc2VEPTB;NT62JI5O MXqxPVIzOzV3Mx?=

... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

プロトコル(参考用のみ)

キナーゼアッセイ:[1]
+ 展開

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
細胞アッセイ: [1]
+ 展開
  • 細胞株: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • 濃度: Dissolved in DMSO, final concentrations ~1 μM
  • 反応時間: 24 and 72 hours
  • 実験の流れ: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (参考用のみ)
動物実験:[1]
+ 展開
  • 動物モデル: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • 製剤: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • 投薬量: ~50 mg/kg
  • 投与方法: Injection i.v. once or twice per week
    (参考用のみ)

溶解度 (25°C)

体外 Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL
体内 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL

* <1 mg/mlは製品が微弱に溶解する或いは溶解しないことを示します。
* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK信号経路図

PLK Inhibitors with Unique Features

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Tags: BI 2536を買う | BI 2536 ic50 | BI 2536供給者 | BI 2536を購入する | BI 2536費用 | BI 2536生産者 | オーダーBI 2536 | BI 2536化学構造 | BI 2536分子量 | BI 2536代理店
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID