BI 2536 化学構造
分子量: 521.66

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製品説明

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  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS1UFJyUUN3ME2wMlAxPzd4IN88US=> NIjJTIZUSU6JRWK=
ACN MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPETWM2OD1yLkCwPFQ{KM7:TR?= M4O0OHNCVkeHUh?=
TE-8 M1:3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEC5OFEh|ryP M2[1c3NCVkeHUh?=
LC-2-ad MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXu2clJTUUN3ME2wMlAyODl|IN88US=> Ml;xV2FPT0WU
ALL-PO M2nIS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TndmlEPTB;MD6wNVMh|ryP Ml;EV2FPT0WU
EW-16 M1P5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjsfohKSzVyPUCuNFE{OzZizszN NF7LS25USU6JRWK=
KM12 M1KwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Pvb2lEPTB;MD6wNVM1QCEQvF2= MnHIV2FPT0WU
GI-1 NEPvbGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3jRm1mUUN3ME2wMlAyOzh|IN88US=> NVHNdWlpW0GQR1XS
LS-411N NF25NnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DrWmlEPTB;MD6wNVQxPyEQvF2= M3K3e3NCVkeHUh?=
ES8 NYOzV3VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPS[pN{UUN3ME2wMlAyPDl2IN88US=> M4jncHNCVkeHUh?=
SNU-C2B M2m3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWzTIFjUUN3ME2wMlAyPTJ4IN88US=> MlThV2FPT0WU
CESS Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEG2NFIh|ryP NWPHbJFPW0GQR1XS
697 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfDdXFKSzVyPUCuNFE3PjhizszN MlfNV2FPT0WU
NCI-H1963 NHjMPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHU[YlqUUN3ME2wMlAyPjd|IN88US=> NV3OOGNnW0GQR1XS
IA-LM NGXUWo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M362cWlEPTB;MD6wNVY5QCEQvF2= NHzSV2lUSU6JRWK=
SW954 Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Ly[mlEPTB;MD6wNVcxPSEQvF2= M4C1eXNCVkeHUh?=
RL95-2 MlTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEG3N|gh|ryP NXHi[oNvW0GQR1XS
LXF-289 NXPV[WtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDUXmZ7UUN3ME2wMlAyPzdizszN MWLTRW5ITVJ?
OCUB-M NYG2U4t{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi2TWM2OD1yLkCxPFI3KM7:TR?= MoLDV2FPT0WU
RKO NV;MVIdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3KTWM2OD1yLkCxPVg4KM7:TR?= NXzDfXBxW0GQR1XS
LOUCY NUiySpc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moq0TWM2OD1yLkCyNFUh|ryP MVnTRW5ITVJ?
NOS-1 NH35cINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrvTWM2OD1yLkCyNFk{KM7:TR?= Mn;3V2FPT0WU
A4-Fuk NUPTZ3l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMEKyNVgh|ryP NVrheok6W0GQR1XS
A388 M3;SPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEKyNlch|ryP Mn;pV2FPT0WU
TE-9 M4rPXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrhTWM2OD1yLkCyNlYyKM7:TR?= MYDTRW5ITVJ?
KURAMOCHI Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTGTWM2OD1yLkCyNlg2KM7:TR?= NFf5To9USU6JRWK=
KALS-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K1ZmlEPTB;MD6wNlM{QCEQvF2= MlL3V2FPT0WU
HOP-62 NWPDeIV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXJd4JKSzVyPUCuNFI1OiEQvF2= NV7wR5pPW0GQR1XS
RPMI-8402 M{ewOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHCTWM2OD1yLkCyOVA5KM7:TR?= M1zDdXNCVkeHUh?=
TE-1 M2LnOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n0d2lEPTB;MD6wNlUyOiEQvF2= MXrTRW5ITVJ?
CCRF-CEM NYXoe49HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH6eIRKSzVyPUCuNFI2PDNizszN Ml;QV2FPT0WU
HUTU-80 NHj0VmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\Gd2IxUUN3ME2wMlAzPjJ2IN88US=> MV\TRW5ITVJ?
NCI-H1648 M1vCPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu2fJhKSzVyPUCuNFI3PDdizszN NHHOZ|lUSU6JRWK=
HCE-4 NWC2VGJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPDTWM2OD1yLkCyOlgzKM7:TR?= MYjTRW5ITVJ?
ETK-1 MoD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLJTWM2OD1yLkCyO|M3KM7:TR?= NEXtfJhUSU6JRWK=
TE-15 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO2bYkyUUN3ME2wMlAzPzN6IN88US=> Mo\nV2FPT0WU
BE-13 NGHXTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m5NGlEPTB;MD6wNlc1KM7:TR?= MYLTRW5ITVJ?
KE-37 NWjLVoM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjsc|ZJUUN3ME2wMlAzPzRzIN88US=> NIPOVVlUSU6JRWK=
NCI-H1355 NFj4WZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPvTWM2OD1yLkCyO|g{KM7:TR?= NFjZXHhUSU6JRWK=
TE-11 NVG0dHdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMEK4NFkh|ryP NXHVVHNFW0GQR1XS
BL-70 NWjQN|BxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Sw[GlEPTB;MD6wNlg2PyEQvF2= NGH4N2FUSU6JRWK=
ES6 NXrj[nZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfhVmZKSzVyPUCuNFI5QDFizszN M{ThbnNCVkeHUh?=
GT3TKB NVnYT|g6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPmdWFOUUN3ME2wMlAzQTV|IN88US=> MVzTRW5ITVJ?
LB647-SCLC M2q4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEOxPVUh|ryP M{H1WnNCVkeHUh?=
NB13 M3\6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M121c2lEPTB;MD6wN|MyPiEQvF2= MmCyV2FPT0WU
ST486 MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHrTWM2OD1yLkCzN|M4KM7:TR?= M16yWXNCVkeHUh?=
NCI-H82 NUixb4MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEOzOFMh|ryP MYPTRW5ITVJ?
NTERA-S-cl-D1 M3nQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTsTWM2OD1yLkCzN|k6KM7:TR?= MnP1V2FPT0WU
ES4 MoT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;G[GZuUUN3ME2wMlA{PDZ|IN88US=> MnroV2FPT0WU
SK-NEP-1 NH;PTlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDQOo9KSzVyPUCuNFM1QTlizszN MVTTRW5ITVJ?
Becker MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HoWWlEPTB;MD6wN|U2PSEQvF2= NW\xWnNWW0GQR1XS
A101D M4fTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SxRWlEPTB;MD6wN|c1QCEQvF2= NUnMe49RW0GQR1XS
SK-UT-1 MlfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEO3O|Qh|ryP MlXpV2FPT0WU
SW982 NWPV[2tQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\lbGtrUUN3ME2wMlA{PzlizszN MW\TRW5ITVJ?
TE-10 NF:3SVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMESwOFYh|ryP MVPTRW5ITVJ?
OVCAR-4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TZWWlEPTB;MD6wOFA2QSEQvF2= M3OwW3NCVkeHUh?=
KP-N-YS MlPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMESwPFUh|ryP MXXTRW5ITVJ?
BL-41 NXjiS486T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HXPWlEPTB;MD6wOFEzPSEQvF2= MX7TRW5ITVJ?
MZ1-PC NIL3cohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTZTWM2OD1yLkC0NVI4KM7:TR?= NWLBe3NmW0GQR1XS
PF-382 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMESxPVgh|ryP NVflbZppW0GQR1XS
MOLT-13 NVnH[Zg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV76bHE1UUN3ME2wMlA1OjN6IN88US=> MUjTRW5ITVJ?
HCC1599 NIS1UIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPY[5hoUUN3ME2wMlA1OjV6IN88US=> M33yWXNCVkeHUh?=
IST-MEL1 M{jIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMES0OFIh|ryP M33JfnNCVkeHUh?=
LU-139 M4PIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP6TWM2OD1yLkC0OFQzKM7:TR?= MVfTRW5ITVJ?
MS-1 NFPtb41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG2UZZKSzVyPUCuNFQ4ODFizszN MnTwV2FPT0WU
MFH-ino M2Ht[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr6O2FKSzVyPUCuNFUxODNizszN MkjsV2FPT0WU
IMR-5 NHS5Xm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvJZ2JpUUN3ME2wMlA2ODJzIN88US=> MkXQV2FPT0WU
TE-5 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEWwOlMh|ryP NIfuXHNUSU6JRWK=
DJM-1 NE\oZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzMXXNKSzVyPUCuNFUyPDJizszN MorrV2FPT0WU
NB17 M1\JcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfxZZNKSzVyPUCuNFUzODdizszN M3LFSnNCVkeHUh?=
KARPAS-45 MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:xTWM2OD1yLkC1N|U5KM7:TR?= MVLTRW5ITVJ?
TGBC1TKB MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP0WVMxUUN3ME2wMlA2PDB3IN88US=> NEDKcotUSU6JRWK=
ML-2 M2Pl[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\IbZBKSzVyPUCuNFU1OTRizszN M3nvPXNCVkeHUh?=
no-10 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMEW0O|Qh|ryP NHz0UWxUSU6JRWK=
CTV-1 MnflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf1dZBKSzVyPUCuNFU2ODJizszN NFq0Z3lUSU6JRWK=
SJSA-1 M4LGNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTsb2J6UUN3ME2wMlA2PTJizszN M4\ieHNCVkeHUh?=
HC-1 NG\UPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfzTWM2OD1yLkC1OVk4KM7:TR?= MYHTRW5ITVJ?
TE-12 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL1TWM2OD1yLkC1OlE{KM7:TR?= M3f2bHNCVkeHUh?=
KY821 NX73TFNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfySJhKSzVyPUCuNFU3OzJizszN MmPKV2FPT0WU
TALL-1 NU\OZVN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEW3NFgh|ryP NEjnd4pUSU6JRWK=
DEL Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\WVGlEPTB;MD6wOVcxQSEQvF2= NXrIfmcxW0GQR1XS
TE-6 NWPEN2NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEW3NlIh|ryP NVXXb5doW0GQR1XS
SK-LMS-1 NEDG[4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HrdWlEPTB;MD6wOVgxPSEQvF2= MoTjV2FPT0WU
EW-1 MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEW4N|ch|ryP M13NTHNCVkeHUh?=
8-MG-BA NU[2cWdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjwOVZKSzVyPUCuNFU5PTFizszN MkfIV2FPT0WU
NALM-6 NXPSOYwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m3T2lEPTB;MD6wOVk4OyEQvF2= NGnx[29USU6JRWK=
LB771-HNC NVK2WmZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEW5O|kh|ryP Mm[yV2FPT0WU
HT-144 NYrNZY06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni0TWM2OD1yLkC2NVMh|ryP MnLuV2FPT0WU
KM-H2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vSUmlEPTB;MD6wOlIzOSEQvF2= MUnTRW5ITVJ?
SF268 NWLMR2ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j5XmlEPTB;MD6wOlI5PiEQvF2= MlLIV2FPT0WU
RS4-11 MoXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqxTWM2OD1yLkC2N|A1KM7:TR?= NF[3dG1USU6JRWK=
MHH-PREB-1 NWqzcnkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPRS2xXUUN3ME2wMlA3OzF7IN88US=> NWHWe|BLW0GQR1XS
ATN-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlf6TWM2OD1yLkC2N|Q2KM7:TR?= NImxWHJUSU6JRWK=
BB30-HNC NEL2eGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrWRW1KSzVyPUCuNFY1OzZizszN MWDTRW5ITVJ?
CPC-N NGnBc5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwME[1NlQh|ryP NX3YPZJuW0GQR1XS
NB1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwME[2NVMh|ryP M4[0WnNCVkeHUh?=
KS-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\mRm1nUUN3ME2wMlA3PzR6IN88US=> M1vGenNCVkeHUh?=
RXF393 NHvKZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TrbmlEPTB;MD6wOlc3PCEQvF2= M1m4NnNCVkeHUh?=
IST-SL2 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XQUWlEPTB;MD6wO|AxPCEQvF2= MknRV2FPT0WU
GI-ME-N MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfVTWM2OD1yLkC3Nlg3KM7:TR?= NG\jcYpUSU6JRWK=
VA-ES-BJ M{XSdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PFN2lEPTB;MD6wO|Q4PSEQvF2= NEKzPWdUSU6JRWK=
NCI-H1581 M4\5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEe0O|gh|ryP MV;TRW5ITVJ?
U-266 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PvTmlEPTB;MD6wO|Q6PyEQvF2= NID5WVBUSU6JRWK=
DMS-114 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrITWM2OD1yLkC3OVI5KM7:TR?= NF\oTG1USU6JRWK=
NCI-H187 NVPjT5VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnFNWVKSzVyPUCuNFc4OjZizszN NEW5[VhUSU6JRWK=
SW962 M3fxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMEe4N|kh|ryP NYXL[Gg2W0GQR1XS
MONO-MAC-6 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPjTWM2OD1yLkC3PVg3KM7:TR?= NGjoUHJUSU6JRWK=
MOLT-16 MnPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f1c2lEPTB;MD6wPFEzOSEQvF2= NXn4bYFDW0GQR1XS
KNS-42 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEixOlEh|ryP MYDTRW5ITVJ?
CMK NVnrdJBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEiyNlUh|ryP NYP3dmE2W0GQR1XS
Ramos-2G6-4C10 M2fMSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\lNmlwUUN3ME2wMlA5OjJ3IN88US=> M1vVenNCVkeHUh?=
Daudi MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLIW2xVUUN3ME2wMlA5OjV4IN88US=> NHrac21USU6JRWK=
NCI-H510A M4P4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjlTWM2OD1yLkC4N|M3KM7:TR?= Mk\iV2FPT0WU
LB831-BLC NYTZdFVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMEi1OlEh|ryP MVjTRW5ITVJ?
HEL M{TlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TjNmlEPTB;MD6wPFY3QCEQvF2= M3PVdXNCVkeHUh?=
LU-134-A MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O1e2lEPTB;MD6wPFcxQCEQvF2= MXPTRW5ITVJ?
NCI-H1694 NFja[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEi3OFQh|ryP M{jlbnNCVkeHUh?=
KGN MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH1NmhPUUN3ME2wMlA5PzV7IN88US=> MX7TRW5ITVJ?
A253 NIPZ[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTuSY9KSzVyPUCuNFg5OjJizszN NHPMclNUSU6JRWK=
DG-75 NWDUTpZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULVXVJnUUN3ME2wMlA5QTJ{IN88US=> M1TsXHNCVkeHUh?=
MOLT-4 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEi5PFMh|ryP MmfKV2FPT0WU
NCI-SNU-5 NEnYUYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDWTWM2OD1yLkC5NlU5KM7:TR?= NVrYN25iW0GQR1XS
ONS-76 M13a[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEmyO|Yh|ryP Mn7kV2FPT0WU
NCI-H446 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli5TWM2OD1yLkC5OFYzKM7:TR?= NE\He3FUSU6JRWK=
COR-L279 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYq2cWFKUUN3ME2wMlA6PTV4IN88US=> MXvTRW5ITVJ?
Calu-6 NWCyVWp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrRTWM2OD1yLkC5OVk5KM7:TR?= MWrTRW5ITVJ?
BC-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\xXmlEPTB;MD6wPVY3OiEQvF2= M1LYSHNCVkeHUh?=
NCI-H2126 NGDIcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEm3PVEh|ryP M3\hdnNCVkeHUh?=
NCI-H1882 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDBcnJxUUN3ME2wMlA6QDB7IN88US=> MVzTRW5ITVJ?
BB65-RCC M3LSV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTOTWM2OD1yLkGwNlk1KM7:TR?= MWjTRW5ITVJ?
DU-4475 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\hTWM2OD1yLkGwOFA4KM7:TR?= M1TBTXNCVkeHUh?=
NCI-H526 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7RcVBKSzVyPUCuNVA1PCEQvF2= MWPTRW5ITVJ?
NEC8 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LkOmlEPTB;MD6xNFUzPSEQvF2= NWTSbWRMW0GQR1XS
NCI-H1304 M4\pWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMUC1PVQh|ryP M2Tmd3NCVkeHUh?=
L-540 M4fxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv1N2VEUUN3ME2wMlExPzB6IN88US=> NIjrUnZUSU6JRWK=
NCI-SNU-16 MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\nb4FKSzVyPUCuNVA4PDJizszN NUDjWnRnW0GQR1XS
HD-MY-Z M3TaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMUC4OVYh|ryP NWnZeWwzW0GQR1XS
K-562 MnH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\DTWM2OD1yLkGwPFU5KM7:TR?= MoPoV2FPT0WU
JAR NHTkcYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHkTWM2OD1yLkGwPVI2KM7:TR?= NH[4N3dUSU6JRWK=
MZ2-MEL MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rVTWlEPTB;MD6xNVA2KM7:TR?= M3vL[nNCVkeHUh?=
L-363 M{W0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfzd5hzUUN3ME2wMlEyODd7IN88US=> NGnpVItUSU6JRWK=
BV-173 MlfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrPVFlvUUN3ME2wMlEyOjR|IN88US=> Ml7OV2FPT0WU
NCI-H524 NF;MRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzlfpJjUUN3ME2wMlEyOjd2IN88US=> NVnxZllFW0GQR1XS
EoL-1-cell NGfJXpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XJZmlEPTB;MD6xNVY4OiEQvF2= MWfTRW5ITVJ?
K052 M1KwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMUG3NVIh|ryP NG\Bb|VUSU6JRWK=
TK10 MoTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPDWHZpUUN3ME2wMlEyPzJ6IN88US=> MVHTRW5ITVJ?
KU812 NHPGbJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f1SGlEPTB;MD6xNlA1PCEQvF2= M1u4c3NCVkeHUh?=
RPMI-8226 M3PMcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMUKwOVIh|ryP M37mTHNCVkeHUh?=
MZ7-mel NWXpcFBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fKRmlEPTB;MD6xNlI{PyEQvF2= MVHTRW5ITVJ?
SK-PN-DW Mk\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[2V2Q6UUN3ME2wMlEzOjh5IN88US=> NVrne4kzW0GQR1XS
SR M1W3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DVdGlEPTB;MD6xNlQ1OSEQvF2= NYL0emNrW0GQR1XS
RPMI-6666 NVe1eI5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMUK3OFMh|ryP NXfaW2FPW0GQR1XS
no-11 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXv3O3F{UUN3ME2wMlEzQDZ7IN88US=> NFP1c4pUSU6JRWK=
EW-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fYO2lEPTB;MD6xNlg6OyEQvF2= NU[wZZRsW0GQR1XS
LAMA-84 NXf0TZdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMUOxPFch|ryP MXLTRW5ITVJ?
HT MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMUO1O|Qh|ryP M3HJUnNCVkeHUh?=
KP-N-RT-BM-1 NVnFVXRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMUO2NVIh|ryP M3\0WXNCVkeHUh?=
NCI-H747 NXTXV5dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;NTWM2OD1yLkGzO{DPxE1? NGfUcohUSU6JRWK=
NCCIT NEWwd3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\QOmlEPTB;MD6xN|k{QSEQvF2= NIDvWpNUSU6JRWK=
MLMA Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{POdmlEPTB;MD6xOFE3PyEQvF2= NX;p[2MxW0GQR1XS
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CAL-148 MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMUS0PFMh|ryP NED6OWdUSU6JRWK=
GB-1 NX[4bmt3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L0UmlEPTB;MD6xOFUzPiEQvF2= NEXxRpdUSU6JRWK=
COR-L88 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP1dXVKSzVyPUCuNVQ5ODJizszN NUXF[W11W0GQR1XS
NKM-1 M3frc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXLPXJKSzVyPUCuNVQ6ODZizszN MmDvV2FPT0WU
NB5 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[5[mlEPTB;MD6xOVQ3OiEQvF2= MXPTRW5ITVJ?
SH-4 NGq1b2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjYOI5KSzVyPUCuNVU1PjZizszN MlXwV2FPT0WU
EM-2 NHHlWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHPblVVUUN3ME2wMlE2PDZ5IN88US=> MWHTRW5ITVJ?
TGBC24TKB NVLid2dVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n6RmlEPTB;MD6xOVY2QSEQvF2= NH;QPGJUSU6JRWK=
SCLC-21H NV\WelZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3XTWlKSzVyPUCuNVU4ODJizszN MWDTRW5ITVJ?
COLO-684 NGfZVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\mNmlEPTB;MD6xOVczOSEQvF2= M{XCT3NCVkeHUh?=
KINGS-1 NYP3fGM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XtUWlEPTB;MD6xOVkyKM7:TR?= Mlr4V2FPT0WU
LS-123 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjGTWM2OD1yLkG1PVE4KM7:TR?= NWTjVWtWW0GQR1XS
MC116 NWLMOYdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\ycWlEPTB;MD6xOlE2QCEQvF2= NGTrV3RUSU6JRWK=
SU-DHL-1 MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMU[yNFYh|ryP M1[4OXNCVkeHUh?=
NCI-H64 MkHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jDdWlEPTB;MD6xOlM1PyEQvF2= NUTBT4ZRW0GQR1XS
HCE-T NHLt[mJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[yTWM2OD1yLkG2OVA1KM7:TR?= MVzTRW5ITVJ?
LOXIMVI NYfqSXlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3OfXJbUUN3ME2wMlE3QTR7IN88US=> NET4dZlUSU6JRWK=
ARH-77 MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jUN2lEPTB;MD6xO|M4QSEQvF2= MUHTRW5ITVJ?
DOHH-2 NVniWI5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnrTWM2OD1yLkG3OlczKM7:TR?= NYf0enFpW0GQR1XS
COLO-320-HSR MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHicHBKSzVyPUCuNVgyPTRizszN NYfwOVF3W0GQR1XS
NB6 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PSfGlEPTB;MD6xPFU3PiEQvF2= MonQV2FPT0WU
L-428 M4jZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\ZUmlEPTB;MD6xPFgyOyEQvF2= NEXDVYtUSU6JRWK=
SNB75 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMUi4NlQh|ryP M{HiSXNCVkeHUh?=
NCI-H2141 NELLPYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHsdIhKSzVyPUCuNVkxOTFizszN NF\0TZpUSU6JRWK=
KARPAS-299 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:1dGh5UUN3ME2wMlE6OjRzIN88US=> M1:2T3NCVkeHUh?=
LC4-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHrTWM2OD1yLkG5OVAzKM7:TR?= NW\IfIpiW0GQR1XS
UACC-257 MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vVd2lEPTB;MD6xPVk1PyEQvF2= MYHTRW5ITVJ?
EVSA-T M4rGOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMkCzNVIh|ryP Mkm3V2FPT0WU
JiyoyeP-2003 MkT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuxPZNKSzVyPUCuNlA1PzdizszN MXfTRW5ITVJ?
NCI-H720 NFz3ZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S5U2lEPTB;MD6yNFUzPSEQvF2= NGrHd2FUSU6JRWK=
GAK NIruTmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O5fGlEPTB;MD6yNVE5QSEQvF2= NXzEVJBtW0GQR1XS
HH MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW0TWM2OD1yLkKxOFA2KM7:TR?= NYfFPWpNW0GQR1XS
NCI-H1436 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fqS2lEPTB;MD6yNVQ3PCEQvF2= Mn3MV2FPT0WU
GR-ST NInJRWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMkG0PFgh|ryP MVvTRW5ITVJ?
BC-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfPcldKSzVyPUCuNlI3OTZizszN M2fGdXNCVkeHUh?=
SIG-M5 M4PPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7DOIRKSzVyPUCuNlI4OjdizszN Ml7TV2FPT0WU
NCI-H345 NWHGd|l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHLTWM2OD1yLkKzPFA2KM7:TR?= NIPJd2tUSU6JRWK=
OPM-2 NFjE[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn1TWM2OD1yLkKzPFgzKM7:TR?= MU\TRW5ITVJ?
LB1047-RCC Mlv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny5TWM2OD1yLkK0OFEh|ryP MkDQV2FPT0WU
CTB-1 M2K1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMkS0PVMh|ryP MmXuV2FPT0WU
A3-KAW MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXpVVBmUUN3ME2wMlI2OzRzIN88US=> MVXTRW5ITVJ?
SF126 MmDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjPbY9KSzVyPUCuNlU{QDNizszN MV7TRW5ITVJ?
KARPAS-422 NIjKXnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrHfXRRUUN3ME2wMlI2PDN3IN88US=> NF7sPWVUSU6JRWK=
MEG-01 M3THSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\LVXFKSzVyPUCuNlU3PzNizszN NXrxc2JMW0GQR1XS
NCI-H209 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrOfHVJUUN3ME2wMlI3Ozd2IN88US=> M1XD[nNCVkeHUh?=
SBC-1 MoDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzZTWM2OD1yLkK2OUDPxE1? M{XodHNCVkeHUh?=
K5 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIO5OohKSzVyPUCuNlY6QDRizszN MXLTRW5ITVJ?
QIMR-WIL NGDJZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLNTWM2OD1yLkK3NVU2KM7:TR?= NIHTdJRUSU6JRWK=
NMC-G1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jnN2lEPTB;MD6yPFIyPyEQvF2= MVnTRW5ITVJ?
IST-MES1 NULRfYJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\hUZhKSzVyPUCuNlkzOzhizszN NHi5bGJUSU6JRWK=
SW684 NGrS[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTxZ|BKSzVyPUCuN|AxPDdizszN NWjCd3VDW0GQR1XS
MV-4-11 MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELTdZFKSzVyPUCuN|A4QDhizszN NYTP[lAxW0GQR1XS
LAN-6 NGHVPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\TTWM2OD1yLkOxOVczKM7:TR?= NEnBSndUSU6JRWK=
RH-1 NXrGfXBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwM{G4O|Eh|ryP NGCyN25USU6JRWK=
CP66-MEL NW\Rc49wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwM{G4O|gh|ryP MVXTRW5ITVJ?
EC-GI-10 M1HocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLqfXNKUUN3ME2wMlMzQTh5IN88US=> MoXVV2FPT0WU
GDM-1 NYTDdlk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwM{OwOVkh|ryP MVrTRW5ITVJ?
IST-SL1 Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL3b|N7UUN3ME2wMlM1QTF2IN88US=> NEX0WW1USU6JRWK=
KMOE-2 MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\Z[WlEPTB;MD6zOVE4PSEQvF2= MUPTRW5ITVJ?
OS-RC-2 M2Pa[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTQdmMzUUN3ME2wMlM2PTR2IN88US=> NXPodFl1W0GQR1XS
HDLM-2 Mnr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nuRWlEPTB;MD6zO|gyPCEQvF2= M2WzNnNCVkeHUh?=
DSH1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX2VHVKSzVyPUCuN|g3OzFizszN NULKT5JlW0GQR1XS
LS-1034 M1LPNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPUTWM2OD1yLkO4PVU1KM7:TR?= Mo\4V2FPT0WU
LB373-MEL-D MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nXPGlEPTB;MD6zPVE6PyEQvF2= NEPDV4xUSU6JRWK=
GOTO M4G0cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIraZW9KSzVyPUCuOFIyOThizszN M{HxWnNCVkeHUh?=
MRK-nu-1 NH\UV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwNEKyNFUh|ryP NH24bmFUSU6JRWK=
SK-MM-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;GTWM2OD1yLkSzOFQzKM7:TR?= MWnTRW5ITVJ?
BOKU MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrMT2ZpUUN3ME2wMlQ{Pzl{IN88US=> NVjRc3poW0GQR1XS
NOMO-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{K5T2lEPTB;MD60N|g3KM7:TR?= M3e4U3NCVkeHUh?=
J-RT3-T3-5 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3rU3Z6UUN3ME2wMlQ1QDd6IN88US=> MVTTRW5ITVJ?
COLO-668 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DPUmlEPTB;MD60OVY3QCEQvF2= NFfMcJdUSU6JRWK=
SF539 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vJN2lEPTB;MD60PFY5PCEQvF2= MoLQV2FPT0WU
LB2518-MEL MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm4dVFkUUN3ME2wMlQ6PzB|IN88US=> NYnQeIo4W0GQR1XS
TE-441-T MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rzOmlEPTB;MD61NFEzKM7:TR?= NWfHR|BEW0GQR1XS
MDA-MB-134-VI NFPVfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCwTWM2OD1yLkWwPVIyKM7:TR?= M3fCVnNCVkeHUh?=
SCC-3 NVLYOY9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHCc2lKSzVyPUCuOVE5PzNizszN M1TaNnNCVkeHUh?=
KLE M33GbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTKTWM2OD1yLkWyNVcyKM7:TR?= NH;VdodUSU6JRWK=
LB2241-RCC Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;XVWNDUUN3ME2wMlUzPTJ3IN88US=> MkjUV2FPT0WU
NCI-H1417 NXvnOpRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwNUO0N|Uh|ryP NHTWPVRUSU6JRWK=
NCI-H2081 M1rySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm3V41KSzVyPUCuOVg3OTFizszN NGfveIhUSU6JRWK=
NCI-H1522 NELSPYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLxc5lKSzVyPUCuOVk{QDNizszN MluzV2FPT0WU
NCI-H889 M1vBZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3MUmVKSzVyPUCuOVk5PDRizszN M1jqNXNCVkeHUh?=
CGTH-W-1 NH;3e45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwNkC3OVUh|ryP Ml;rV2FPT0WU
EB-3 M{K4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnvXZpyUUN3ME2wMlYyOTV|IN88US=> M{DwZ3NCVkeHUh?=
D-336MG MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwNkG3PVEh|ryP NGm2fVRUSU6JRWK=
LC-1F NYC1T|RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGexZmdKSzVyPUCuOlI2QTJizszN MUXTRW5ITVJ?
MHH-NB-11 M4jMfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf0TWM2OD1yLk[zPFAyKM7:TR?= M1[5NHNCVkeHUh?=
SK-N-FI NEO2WW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTSTWM2OD1yLk[zPVEh|ryP M3npWXNCVkeHUh?=
NCI-H69 NX[0SHgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DUSWlEPTB;MD62OFg4QSEQvF2= NWrhOo9zW0GQR1XS
SCH MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LremlEPTB;MD62OlAzOyEQvF2= NFnHUYlUSU6JRWK=
LS-513 NG[yVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\wSFNKSzVyPUCuOlczPTlizszN NYr2[WhXW0GQR1XS
CP67-MEL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwNke1PVYh|ryP NF;NfmRUSU6JRWK=
GCIY NWHTXZljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TKTGlEPTB;MD63NFM3OyEQvF2= M2\1b3NCVkeHUh?=
SHP-77 MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITpPXdKSzVyPUCuO|A4OzRizszN NXLUbIY5W0GQR1XS
EHEB M4DxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTKTWM2OD1yLkexPFU1KM7:TR?= NUWwdYJMW0GQR1XS
D-247MG M4\OeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq1XIEyUUN3ME2wMlc{OjN{IN88US=> NYjFOo1WW0GQR1XS
Raji NF;FUWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfkVYJxUUN3ME2wMlc1QTh7IN88US=> NWCxTXUyW0GQR1XS
MPP-89 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLsTWM2OD1yLke1PVc5KM7:TR?= NFG5fWZUSU6JRWK=
EKVX NYL0UlNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7IcVNKSzVyPUCuO|kxPzNizszN NGPidHlUSU6JRWK=
HCC2218 M3v6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwN{mxN|Eh|ryP NGTubnJUSU6JRWK=
KNS-81-FD NGLEbY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz0[lRHUUN3ME2wMlgyODFzIN88US=> MnjxV2FPT0WU
HCC2157 NUn0WZM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\OTo9KSzVyPUCuPFQ6PTFizszN NIHtdotUSU6JRWK=
BT-474 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLkTWM2OD1yLki4PFU1KM7:TR?= M3PxWHNCVkeHUh?=
NCI-H748 M2LqXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;ETWM2OD1yLkmxNkDPxE1? MUjTRW5ITVJ?
EW-24 MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL6TWM2OD1yLkmyNFAzKM7:TR?= MYTTRW5ITVJ?
D-263MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D0cGlEPTB;MD65OFUyOiEQvF2= MWjTRW5ITVJ?
OMC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwOU[zO|Mh|ryP Mn3zV2FPT0WU
NCI-H2196 Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwOUe3O|ch|ryP NX\P[lh7W0GQR1XS
HAL-01 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXZTWM2OD1yLkm5PFczKM7:TR?= MVLTRW5ITVJ?
NCI-H2107 M3nlN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vFPWlEPTB;MT6wNVg2PCEQvF2= MUjTRW5ITVJ?
LB996-RCC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXiTWM2OD1zLkC4NFUyKM7:TR?= MXfTRW5ITVJ?
NCI-H1395 NIrrR41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP6TYlFUUN3ME2xMlExPjdizszN MVzTRW5ITVJ?
CHP-126 NYLaR|JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonBTWM2OD1zLkG2NVk6KM7:TR?= NF\xbnJUSU6JRWK=
NB69 NGq4NZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfGTWM2OD1zLkK2NVQ5KM7:TR?= MluwV2FPT0WU
CAS-1 M3KxU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwM{SyN|Eh|ryP NH\hSYJUSU6JRWK=
JVM-3 NEjiZ45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTFwNEe4OVUh|ryP MX3TRW5ITVJ?
DMS-153 M3[ycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTFwNUe2O|Qh|ryP M3nXWnNCVkeHUh?=
SK-MEL-2 MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTMTWM2OD1zLkexO|g6KM7:TR?= MoHpV2FPT0WU
NCI-H1155 NILiO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LxcWlEPTB;MT63N|Y4PiEQvF2= MYjTRW5ITVJ?
NCI-H1092 M4PrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[3bGlEPTB;MT63OlE5OiEQvF2= MmfPV2FPT0WU
LU-165 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\afGRKSzVyPUGuPFY1PzZizszN NWrNSYt[W0GQR1XS
HL-60 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnt[3dKSzVyPUGuPVk6ODhizszN NFLaPW1USU6JRWK=
REH NY[1WoxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPMfJd4UUN3ME2yMlAxPTh{IN88US=> MkDkV2FPT0WU
JVM-2 Ml7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nxeWlEPTB;Mj6wOlE{PSEQvF2= MX;TRW5ITVJ?
MN-60 NHvlNHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnEe3pRUUN3ME2yMlE4OzB6IN88US=> Mk\iV2FPT0WU
SCC-15 NYHEW2tsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJwMkCyO{DPxE1? M2\TWnNCVkeHUh?=
SNU-C1 NXXQbHhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDOcZdHUUN3ME2yMlIyOzR|IN88US=> MkLhV2FPT0WU
SK-MEL-1 NUH4Z5hST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJwM{KwOFch|ryP NF;5NIxUSU6JRWK=
TGW NV;JPFAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LsVWlEPTB;Mj6zOVAzPyEQvF2= NX3TdlBOW0GQR1XS
CA46 NWTwOZNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYS4bWJ2UUN3ME2yMlc2QTZ5IN88US=> MlXzV2FPT0WU
NCI-H23 MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJwOEC3PVEh|ryP NV3odZU1W0GQR1XS
MMAC-SF NG[ybI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH3NnRoUUN3ME2yMlg3PjJ6IN88US=> NXyyUYg3W0GQR1XS
NCI-H2171 M4qwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPtcmFKSzVyPUOuNFM1PDhizszN MXnTRW5ITVJ?
A704 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\qTWM2OD1|LkG0NVk1KM7:TR?= M1r1NXNCVkeHUh?=
DB NEH6T2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTNwMkW1O|Yh|ryP NVywcXdpW0GQR1XS
NCI-H719 NWP3Z2ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoeyTWM2OD1|LkOwN|g1KM7:TR?= MljaV2FPT0WU
MC-CAR M3OxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNwNUS4NVch|ryP NY\2dWpZW0GQR1XS
SIMA MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPNTWM2OD1|LkW4OFE3KM7:TR?= MV3TRW5ITVJ?
SW872 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnRS3FKSzVyPUOuO|gyODFizszN M3PtXHNCVkeHUh?=
HCC1187 NFXWepNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvQco83UUN3ME2zMlc5OzF3IN88US=> MWPTRW5ITVJ?
EW-13 NIjq[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTNwOEO0NVch|ryP NHzjSINUSU6JRWK=
NCI-SNU-1 M3\zNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTRwMkG5PVkh|ryP MYrTRW5ITVJ?
NCI-H226 NHXaZnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W3TWlEPTB;ND6zN|YxPiEQvF2= NHjHO2JUSU6JRWK=
RPMI-8866 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnoUIZ1UUN3ME20MlM3ODJ7IN88US=> NHraNVhUSU6JRWK=
OCI-AML2 NGPoTZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TSV2lEPTB;ND61OVI{KM7:TR?= NWK5NI5UW0GQR1XS
LU-65 NGDXfXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTRwOUOwN|Mh|ryP NHTwV3hUSU6JRWK=
SK-N-DZ NXHyfWZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\ofopUUUN3ME21MlY{PDZ3IN88US=> MWTTRW5ITVJ?
NB14 NGjwcVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\DTWM2OD13Lkm3NVM2KM7:TR?= NFTLVZpUSU6JRWK=
COLO-829 NFzZZVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXRZm1KSzVyPU[uN|M{PTlizszN NHq5W4dUSU6JRWK=
MHH-CALL-2 NHP2UGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPB[4FKSzVyPU[uOVE2ODhizszN NYnCO41QW0GQR1XS
NCI-H1770 Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[zTWM2OD14Lk[2PVA1KM7:TR?= MmTqV2FPT0WU
ECC4 NUHjNZllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET4Z|VKSzVyPU[uPFIyPzlizszN NG\P[3dUSU6JRWK=
A498 NF3U[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\meWlEPTB;Nj64O|E6OiEQvF2= MknPV2FPT0WU
DMS-79 NIWyPHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzFS4xKSzVyPUeuNFQ2OTJizszN MnWxV2FPT0WU
P30-OHK NEnXOnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVm1fVdxUUN3ME23MlIyQTB4IN88US=> NHvv[ZhUSU6JRWK=
D-502MG NFTpWYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILoUopKSzVyPUeuPVg{PiEQvF2= NVvSdmtzW0GQR1XS
RCC10RGB M3TTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRThwME[yPEDPxE1? NUfPUpBsW0GQR1XS
U-698-M MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRThwMkmyNlYh|ryP MXLTRW5ITVJ?
BB49-HNC M3vVfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\NOHo1UUN3ME25MlQzOjZ3IN88US=> MmixV2FPT0WU
ES1 M3\iPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\sbmg6UUN3ME25MlY5QTV4IN88US=> NE\B[2tUSU6JRWK=
MFM-223 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfDVGVWUUN3ME2xNE46QTJ5IN88US=> NH;JSo1USU6JRWK=
C2BBe1 M2jQXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XwT2lEPTB;MUGuN|UzOyEQvF2= NVHSfIZpW0GQR1XS
EB2 M{\wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHYVW84UUN3ME2xNk43QDhzIN88US=> MYDTRW5ITVJ?
C8166 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrHTWM2OD1zMz64N|A{KM7:TR?= Mmj3V2FPT0WU
ES3 M{LO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M12yTmlEPTB;MUOuPVk4PyEQvF2= MVfTRW5ITVJ?
NCI-H1650 M3:2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DFNWlEPTB;MU[uN|c3PSEQvF2= NV7ad5RbW0GQR1XS
Mo-T MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzPRo52UUN3ME2xO{41ODJ7IN88US=> NXuwRXN3W0GQR1XS
NB7 NYmwPJN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;yTYRKSzVyPUG3Mlc1PjdizszN MkHEV2FPT0WU
ES7 NEfpc29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3FTZV4UUN3ME2xPU42PTB5IN88US=> M3;3[HNCVkeHUh?=
ES5 NUDQNnlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TWUmlEPTB;MkGuO|Y4OSEQvF2= NVP5T3M1W0GQR1XS
MSTO-211H NU\kWoNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvnVHhDUUN3ME2yNU45QDV6IN88US=> M{HHUHNCVkeHUh?=
U-87-MG NIjZVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfVTphEUUN3ME2yOU4yQTZ4IN88US=> NXW4fHpVW0GQR1XS
THP-1 NILreo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3DSFRKSzVyPUK5MlczODFizszN NX3YXVhwW0GQR1XS
NB10 NIrHV45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPvVIxEUUN3ME2zNE4zPjl2IN88US=> NV3xclhNW0GQR1XS
NH-12 NVW0OZJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTN|LkKwNVch|ryP M4PSO3NCVkeHUh?=
COLO-824 NVfTXXBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTN2LkGwNFYh|ryP NVr3OI1GW0GQR1XS
SKM-1 M{fFZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ntS2lEPTB;M{euPFQzOiEQvF2= NWTrSY84W0GQR1XS
NCI-H1838 NFfSWpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\oTWM2OD1|OD6zO|k4KM7:TR?= MWLTRW5ITVJ?
RL NYDh[IhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT2eIRxUUN3ME2zPU4zPDd5IN88US=> MVnTRW5ITVJ?
COLO-800 NVm0fXlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTRyLkC3O|Mh|ryP NHu5PJFUSU6JRWK=
KG-1 M4jPd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P5d2lEPTB;NECuPFk2PSEQvF2= NYC3fm4xW0GQR1XS
TUR M4H3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTRzLk[zPVkh|ryP MYTTRW5ITVJ?
LNCaP-Clone-FGC M3T0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTRzLkmwNVch|ryP MX7TRW5ITVJ?
NCI-H322M M3K0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vicmlEPTB;NEKuOVk5PCEQvF2= MUXTRW5ITVJ?
LNCaP  MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zufGlEPTB;OUGuN{BvVQ>? NXqyem03OjV3MEWxO|Q>
C4-2 M4nUUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRThibl2= MnvKNlU2ODVzN{S=
JURKAT NXzJe2hPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYeyOEBp M4DrUGlEPTB;NEG2MlY3KG6P NGCwWoozPDVzOUm5OS=>
MOLT-4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYCyOEBp MV\JR|UxRTJ6NUOuOUBvVQ>? MnTYNlQ2OTl7OUW=
REH MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVqyOEBp MljYTWM2OD1{OEeuOlghdk1? NYPibIlmOjR3MUm5PVU>
NALM-6 NIfneoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUOyOEBp NVTjUGNlUUN3ME2zOFM{OCCwTR?= MUOyOFUyQTl7NR?=
RS 4;11 M3vqbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\RTXIzPCCq NULwbWoyUUN3ME21NVkvODVibl2= M{DnPVI1PTF7OUm1
697 M4\Ifmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vKTVI1KGh? NI\MfnZKSzVyPUKxNFcvOSCwTR?= NFizSWIzPDVzOUm5OS=>
SIL-ALL NU\KVJZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L1ZlI1KGh? MoXVTWM2OD1zOUmuO|chdk1? M4noXlI1PTF7OUm1
CEM MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHxNlQhcA>? MUDJR|UxRTV{LkG4JI5O Mn7MNlQ2OTl7OUW=
P12 M2\QTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVWyOEBp MmDnTWM2OD1|OT6yO{BvVQ>? M3i5R|I1PTF7OUm1
NALM-16 NEHE[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzTNlQhcA>? M3vxemlEPTB;OU[uNlghdk1? MmqxNlQ2OTl7OUW=
JURKAT MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[2OFghcA>? MWXJR|UxRTF2Lki0JI5O M4\ZbFI1PTF7OUm1
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... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

文献中の引用 (52)

Frequently Asked Questions

  • Question 1
    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

    Answer: For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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* 必須

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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