BI 2536 化学構造
分子量: 521.66

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Quality Control & MSDS

製品説明

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    PLK製品生物活性の比較
  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 NXzDdFF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEC3O|Yh|ryP NYTYdI4zW0GQR1XS
ACN NF3HSWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnrbZFKSzVyPUCuNFA5PDNizszN M2fJ[nNCVkeHUh?=
TE-8 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHS0[VJKSzVyPUCuNFA6PDFizszN MnPmV2FPT0WU
LC-2-ad M{K4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPNTWM2OD1yLkCxNFk{KM7:TR?= MYPTRW5ITVJ?
ALL-PO MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnVSWhqUUN3ME2wMlAyOyEQvF2= MUPTRW5ITVJ?
EW-16 NYPMOGZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X1ZWlEPTB;MD6wNVM{PiEQvF2= M2fiU3NCVkeHUh?=
KM12 M2jENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\lNmlEPTB;MD6wNVM1QCEQvF2= MYjTRW5ITVJ?
GI-1 NVXjbXZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PZ[2lEPTB;MD6wNVM5OyEQvF2= NU[4V5RMW0GQR1XS
LS-411N NIDMOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC5UItKSzVyPUCuNFE1ODdizszN MXjTRW5ITVJ?
ES8 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:2TWM2OD1yLkCxOFk1KM7:TR?= NYLZWoxXW0GQR1XS
SNU-C2B MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi5OI9KSzVyPUCuNFE2OjZizszN M3T2V3NCVkeHUh?=
CESS M2XLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;UepNlUUN3ME2wMlAyPjB{IN88US=> MVzTRW5ITVJ?
697 NWHY[oFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK5TWM2OD1yLkCxOlY5KM7:TR?= Mn3WV2FPT0WU
NCI-H1963 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEG2O|Mh|ryP NEXwNppUSU6JRWK=
IA-LM NXLLV29sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULIPJVEUUN3ME2wMlAyPjh6IN88US=> M1foWXNCVkeHUh?=
SW954 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEG3NFUh|ryP MlnsV2FPT0WU
RL95-2 NXiyXZB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPod45KSzVyPUCuNFE4OzhizszN NHvCS29USU6JRWK=
LXF-289 NX3PXlVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXL[plKSzVyPUCuNFE4PyEQvF2= NXjDTXVRW0GQR1XS
OCUB-M M3PGSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDyTWM2OD1yLkCxPFI3KM7:TR?= MWfTRW5ITVJ?
RKO NGXmXVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEG5PFch|ryP M{PMSHNCVkeHUh?=
LOUCY M1rhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO3c3FKSzVyPUCuNFIxPSEQvF2= NF\ScJFUSU6JRWK=
NOS-1 M{fwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r1OWlEPTB;MD6wNlA6OyEQvF2= M{DVXnNCVkeHUh?=
A4-Fuk M2PiTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[4TWM2OD1yLkCyNlE5KM7:TR?= MnnFV2FPT0WU
A388 MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnqSlR6UUN3ME2wMlAzOjJ5IN88US=> MWnTRW5ITVJ?
TE-9 NF3uO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvZcWNKSzVyPUCuNFIzPjFizszN MV7TRW5ITVJ?
KURAMOCHI MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTq[HQzUUN3ME2wMlAzOjh3IN88US=> MV3TRW5ITVJ?
KALS-1 NHrofpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHtTWM2OD1yLkCyN|M5KM7:TR?= NXr6TpFvW0GQR1XS
HOP-62 MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFqxd5pKSzVyPUCuNFI1OiEQvF2= NULVVpFpW0GQR1XS
RPMI-8402 NYr2U|Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEK1NFgh|ryP NGTyUI5USU6JRWK=
TE-1 NX3BUWhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEK1NVIh|ryP M{PkWnNCVkeHUh?=
CCRF-CEM NXLQdmZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEK1OFMh|ryP MnjyV2FPT0WU
HUTU-80 NILDTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\uV2lEPTB;MD6wNlYzPCEQvF2= NFfoTYxUSU6JRWK=
NCI-H1648 MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\yeJF1UUN3ME2wMlAzPjR5IN88US=> MYLTRW5ITVJ?
HCE-4 NVHafYlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:4TWM2OD1yLkCyOlgzKM7:TR?= MofZV2FPT0WU
ETK-1 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEK3N|Yh|ryP M2DK[3NCVkeHUh?=
TE-15 NXXa[W9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEK3N|gh|ryP M4LJ[HNCVkeHUh?=
BE-13 M1LvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXyTWM2OD1yLkCyO|Qh|ryP Mn\0V2FPT0WU
KE-37 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[2RotKSzVyPUCuNFI4PDFizszN MoPGV2FPT0WU
NCI-H1355 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPlTWM2OD1yLkCyO|g{KM7:TR?= NVLM[2JWW0GQR1XS
TE-11 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEK4NFkh|ryP MXrTRW5ITVJ?
BL-70 M12zNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PXVmlEPTB;MD6wNlg2PyEQvF2= M3XDRnNCVkeHUh?=
ES6 M1K2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEL1[Y1KSzVyPUCuNFI5QDFizszN NYfM[3NIW0GQR1XS
GT3TKB NEOxXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP2TWM2OD1yLkCyPVU{KM7:TR?= NUHlO4RqW0GQR1XS
LB647-SCLC MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X5bWlEPTB;MD6wN|E6PSEQvF2= MlztV2FPT0WU
NB13 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEOzNVYh|ryP NHf0UINUSU6JRWK=
ST486 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3SdGlKSzVyPUCuNFM{OzdizszN MniwV2FPT0WU
NCI-H82 NHfMSnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljNTWM2OD1yLkCzN|Q{KM7:TR?= MnXoV2FPT0WU
NTERA-S-cl-D1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXq5WFZwUUN3ME2wMlA{Ozl7IN88US=> Mke2V2FPT0WU
ES4 NGrZdnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfacGFKSzVyPUCuNFM1PjNizszN MmXoV2FPT0WU
SK-NEP-1 Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTlfFA4UUN3ME2wMlA{PDl7IN88US=> MmLOV2FPT0WU
Becker MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjHTWM2OD1yLkCzOVU2KM7:TR?= NUW2UoNXW0GQR1XS
A101D NVfkV|lTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz3NYFKSzVyPUCuNFM4PDhizszN MYLTRW5ITVJ?
SK-UT-1 NYHIZVBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEO3O|Qh|ryP NGPuWJJUSU6JRWK=
SW982 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDFNo16UUN3ME2wMlA{PzlizszN MnrMV2FPT0WU
TE-10 NYLCUWlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMESwOFYh|ryP MXHTRW5ITVJ?
OVCAR-4 M2DHRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzqSW1KSzVyPUCuNFQxPTlizszN M2nNZXNCVkeHUh?=
KP-N-YS NXTpb5l7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLiTWM2OD1yLkC0NFg2KM7:TR?= Ml;hV2FPT0WU
BL-41 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHf1R2ZKSzVyPUCuNFQyOjVizszN MWjTRW5ITVJ?
MZ1-PC MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3vbXlKSzVyPUCuNFQyOjdizszN MXfTRW5ITVJ?
PF-382 NITOe4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMESxPVgh|ryP NWHKWoVuW0GQR1XS
MOLT-13 NFLmSmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDGeZNKSzVyPUCuNFQzOzhizszN NX7ZRppYW0GQR1XS
HCC1599 NYXhS3dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;ZOVhKSzVyPUCuNFQzPThizszN NVi1[4ppW0GQR1XS
IST-MEL1 NXvtT3NiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnlVHBKSzVyPUCuNFQ1PDJizszN MULTRW5ITVJ?
LU-139 MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHofJBKSzVyPUCuNFQ1PDJizszN M3\TenNCVkeHUh?=
MS-1 MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMES3NFEh|ryP MmfxV2FPT0WU
MFH-ino M{HJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEWwNFMh|ryP NIDWXVBUSU6JRWK=
IMR-5 NFv4SVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEWwNlEh|ryP NW\TfXZkW0GQR1XS
TE-5 NHyzZphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEWwOlMh|ryP MmfSV2FPT0WU
DJM-1 NEjaPZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnJVpJuUUN3ME2wMlA2OTR{IN88US=> NXrGfZlFW0GQR1XS
NB17 M{WwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEWyNFch|ryP MmCyV2FPT0WU
KARPAS-45 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEWzOVgh|ryP NFfrfVFUSU6JRWK=
TGBC1TKB NWHRS2RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjJdJQyUUN3ME2wMlA2PDB3IN88US=> NVLYe3FXW0GQR1XS
ML-2 MnjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3OTWM2OD1yLkC1OFE1KM7:TR?= NV;aNoYzW0GQR1XS
no-10 MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDpXlRKSzVyPUCuNFU1PzRizszN NXflO49bW0GQR1XS
CTV-1 M3Lxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L2OWlEPTB;MD6wOVUxOiEQvF2= MUXTRW5ITVJ?
SJSA-1 NHHRS2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPiS|B4UUN3ME2wMlA2PTJizszN M4qxT3NCVkeHUh?=
HC-1 NH\tdIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LRSmlEPTB;MD6wOVU6PyEQvF2= M2ezXHNCVkeHUh?=
TE-12 NY\UWJVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGzR3pKSzVyPUCuNFU3OTNizszN MmDCV2FPT0WU
KY821 NVnXTJY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEW2N|Ih|ryP NUX4TYJNW0GQR1XS
TALL-1 M1TZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;jTWM2OD1yLkC1O|A5KM7:TR?= MYTTRW5ITVJ?
DEL NVPCeG9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEW3NFkh|ryP NH64N4dUSU6JRWK=
TE-6 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fTVWlEPTB;MD6wOVczOiEQvF2= NX23[49UW0GQR1XS
SK-LMS-1 M1H5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\NU3R{UUN3ME2wMlA2QDB3IN88US=> MoiyV2FPT0WU
EW-1 NXm5d|ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3FcZZGUUN3ME2wMlA2QDN5IN88US=> MlOyV2FPT0WU
8-MG-BA MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMEW4OVEh|ryP M{PUN3NCVkeHUh?=
NALM-6 NIKyOlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vu[2lEPTB;MD6wOVk4OyEQvF2= M2XVTHNCVkeHUh?=
LB771-HNC MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LHN2lEPTB;MD6wOVk4QSEQvF2= NEnNb4xUSU6JRWK=
HT-144 M2nv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwME[xN{DPxE1? NWTieIhpW0GQR1XS
KM-H2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnue4ZKSzVyPUCuNFYzOjFizszN MVrTRW5ITVJ?
SF268 M2qyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTFd5VjUUN3ME2wMlA3Ojh4IN88US=> NIrSO5JUSU6JRWK=
RS4-11 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwME[zNFQh|ryP MmXlV2FPT0WU
MHH-PREB-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\sXWlEPTB;MD6wOlMyQSEQvF2= NUe0NJJ[W0GQR1XS
ATN-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fnZmlEPTB;MD6wOlM1PSEQvF2= MVLTRW5ITVJ?
BB30-HNC M1fHNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuwTWM2OD1yLkC2OFM3KM7:TR?= NHXoVZJUSU6JRWK=
CPC-N MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE[5R|RKSzVyPUCuNFY2OjRizszN NVTFb3JLW0GQR1XS
NB1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnSTlFyUUN3ME2wMlA3PjF|IN88US=> MUDTRW5ITVJ?
KS-1 NEnjTYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwME[3OFgh|ryP Ml:zV2FPT0WU
RXF393 NHGxcmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj3TWM2OD1yLkC2O|Y1KM7:TR?= M1PiTXNCVkeHUh?=
IST-SL2 NGHpUlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEewNFQh|ryP NGrCOIhUSU6JRWK=
GI-ME-N MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInBNWtKSzVyPUCuNFczQDZizszN M{m4bXNCVkeHUh?=
VA-ES-BJ MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV61XGFFUUN3ME2wMlA4PDd3IN88US=> NV\IO|ZtW0GQR1XS
NCI-H1581 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M172c2lEPTB;MD6wO|Q4QCEQvF2= NYLncFFXW0GQR1XS
U-266 NHu3[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3Jb4VEUUN3ME2wMlA4PDl5IN88US=> NHy1RYZUSU6JRWK=
DMS-114 NV\wcppLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\ZcmlzUUN3ME2wMlA4PTJ6IN88US=> Mo[1V2FPT0WU
NCI-H187 NYLofFQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu4SpZWUUN3ME2wMlA4PzJ4IN88US=> MVPTRW5ITVJ?
SW962 NXH3flRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17jd2lEPTB;MD6wO|g{QSEQvF2= MXfTRW5ITVJ?
MONO-MAC-6 MmXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMEe5PFYh|ryP NHPqXmxUSU6JRWK=
MOLT-16 NILLS|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEixNlEh|ryP MljCV2FPT0WU
KNS-42 M2fPZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjCT4RbUUN3ME2wMlA5OTZzIN88US=> NIG2WVJUSU6JRWK=
CMK NWj4[5V6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XCc2lEPTB;MD6wPFIzPSEQvF2= NWnROYlKW0GQR1XS
Ramos-2G6-4C10 NXjYNZNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHkdVJKSzVyPUCuNFgzOjVizszN NWHYXZRJW0GQR1XS
Daudi NFTwXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH4cYpTUUN3ME2wMlA5OjV4IN88US=> NGrJNXNUSU6JRWK=
NCI-H510A NVHMSXc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTrTWM2OD1yLkC4N|M3KM7:TR?= NX;NOm5rW0GQR1XS
LB831-BLC M3;Vdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEi1OlEh|ryP Mlz6V2FPT0WU
HEL NULZOmE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmToTWM2OD1yLkC4OlY5KM7:TR?= MVHTRW5ITVJ?
LU-134-A MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHVUIlKSzVyPUCuNFg4ODhizszN NH3kSndUSU6JRWK=
NCI-H1694 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEi3OFQh|ryP MUnTRW5ITVJ?
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KLE NG\MZ4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HGW2lEPTB;MD61NlE4OSEQvF2= Mn\tV2FPT0WU
LB2241-RCC M2\pfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnQTWM2OD1yLkWyOVI2KM7:TR?= NILTOWFUSU6JRWK=
NCI-H1417 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u1VWlEPTB;MD61N|Q{PSEQvF2= NIXrZ3NUSU6JRWK=
NCI-H2081 NXT3WZJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwNUi2NVEh|ryP MX\TRW5ITVJ?
NCI-H1522 NGXiO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2T6TWlEPTB;MD61PVM5OyEQvF2= MoTHV2FPT0WU
NCI-H889 Mn3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LpXGlEPTB;MD61PVg1PCEQvF2= NITaWIVUSU6JRWK=
CGTH-W-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwNkC3OVUh|ryP MkHOV2FPT0WU
EB-3 MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;KZVRkUUN3ME2wMlYyOTV|IN88US=> MWfTRW5ITVJ?
D-336MG NGrqXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITxe2tKSzVyPUCuOlE4QTFizszN NG\kb|FUSU6JRWK=
LC-1F MnyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fFTWlEPTB;MD62NlU6OiEQvF2= Mn3SV2FPT0WU
MHH-NB-11 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPPTWM2OD1yLk[zPFAyKM7:TR?= NFfY[pRUSU6JRWK=
SK-N-FI MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;1PGNKSzVyPUCuOlM6OSEQvF2= M1\XUXNCVkeHUh?=
NCI-H69 M3TFbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TS[WlEPTB;MD62OFg4QSEQvF2= MX3TRW5ITVJ?
SCH M1LMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwNk[wNlMh|ryP MXnTRW5ITVJ?
LS-513 M1zuVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonpTWM2OD1yLk[3NlU6KM7:TR?= NVPxdVNYW0GQR1XS
CP67-MEL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37R[GlEPTB;MD62O|U6PiEQvF2= M{PrdHNCVkeHUh?=
GCIY NVTvcmZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3GbINKSzVyPUCuO|A{PjNizszN MV7TRW5ITVJ?
SHP-77 NVfYVmpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvYWoVKSzVyPUCuO|A4OzRizszN NUTRbWV4W0GQR1XS
EHEB NFLQNYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7LdIx4UUN3ME2wMlcyQDV2IN88US=> M4Pad3NCVkeHUh?=
D-247MG Mnv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwN{OyN|Ih|ryP M325XXNCVkeHUh?=
Raji NUf0eG51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfUR441UUN3ME2wMlc1QTh7IN88US=> NWGyc2RSW0GQR1XS
MPP-89 NImxOINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrHPZhKSzVyPUCuO|U6PzhizszN NYfDW3BYW0GQR1XS
EKVX NYGxeXlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfoU3ZKSzVyPUCuO|kxPzNizszN MWDTRW5ITVJ?
HCC2218 NUTQUnBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW1XmdIUUN3ME2wMlc6OTNzIN88US=> NFXIO2hUSU6JRWK=
KNS-81-FD MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy1O|VrUUN3ME2wMlgyODFzIN88US=> NWjWS21bW0GQR1XS
HCC2157 MnL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vwVGlEPTB;MD64OFk2OSEQvF2= NUPpT2JrW0GQR1XS
BT-474 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfuOpFKSzVyPUCuPFg5PTRizszN NHvuSWhUSU6JRWK=
NCI-H748 NGnWdlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPXWpBKSzVyPUCuPVEzKM7:TR?= M1n5SnNCVkeHUh?=
EW-24 M3WzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT1TWM2OD1yLkmyNFAzKM7:TR?= M4[yeHNCVkeHUh?=
D-263MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LWO2lEPTB;MD65OFUyOiEQvF2= M3jvXHNCVkeHUh?=
OMC-1 NXjNTFFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17B[WlEPTB;MD65OlM4OyEQvF2= M2TuZXNCVkeHUh?=
NCI-H2196 NETtcXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLGTWM2OD1yLkm3O|c4KM7:TR?= NWfKRnNbW0GQR1XS
HAL-01 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwOUm4O|Ih|ryP M4LhSHNCVkeHUh?=
NCI-H2107 NVi4XW0xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFwMEG4OVQh|ryP NYGxVWRRW0GQR1XS
LB996-RCC Mn73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPJeHdKSzVyPUGuNFgxPTFizszN NX3j[FhWW0GQR1XS
NCI-H1395 NWLD[2I3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFwMUC2O{DPxE1? MXHTRW5ITVJ?
CHP-126 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17HOmlEPTB;MT6xOlE6QSEQvF2= NUK0XIF1W0GQR1XS
NB69 M1;Tdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3GxdGlEPTB;MT6yOlE1QCEQvF2= MV3TRW5ITVJ?
CAS-1 MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f0NWlEPTB;MT6zOFI{OSEQvF2= M3T4bXNCVkeHUh?=
JVM-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XIcGlEPTB;MT60O|g2PSEQvF2= M3PzfXNCVkeHUh?=
DMS-153 M4[3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj1VGFKSzVyPUGuOVc3PzRizszN NV\MT5NxW0GQR1XS
SK-MEL-2 NEOybnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTFwN{G3PFkh|ryP NVG5c4lMW0GQR1XS
NCI-H1155 NGfN[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnDbollUUN3ME2xMlc{Pjd4IN88US=> MlLyV2FPT0WU
NCI-H1092 NXTRV45UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\6OYNzUUN3ME2xMlc3OTh{IN88US=> Ml\UV2FPT0WU
LU-165 MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XVXmlEPTB;MT64OlQ4PiEQvF2= MUXTRW5ITVJ?
HL-60 M3XWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF73VJdKSzVyPUGuPVk6ODhizszN MXrTRW5ITVJ?
REH M2O5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q1e2lEPTB;Mj6wNFU5OiEQvF2= MmTWV2FPT0WU
JVM-2 NIK5eHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3BRVNKSzVyPUKuNFYyOzVizszN M2TTNHNCVkeHUh?=
MN-60 M2TafWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwMUezNFgh|ryP MoDuV2FPT0WU
SCC-15 NWjSNlgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXSWVFKSzVyPUKuNlAzPyEQvF2= NUjSbnpmW0GQR1XS
SNU-C1 NX3XS291T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n4RmlEPTB;Mj6yNVM1OyEQvF2= MUjTRW5ITVJ?
SK-MEL-1 MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJwM{KwOFch|ryP MWDTRW5ITVJ?
TGW MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzaSHVKSzVyPUKuN|UxOjdizszN NIfiPWRUSU6JRWK=
CA46 NXfEVJh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwN{W5Olch|ryP M1nZbXNCVkeHUh?=
NCI-H23 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJwOEC3PVEh|ryP NGSxXnJUSU6JRWK=
MMAC-SF NXm1W|BnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v5[mlEPTB;Mj64OlYzQCEQvF2= M1vueXNCVkeHUh?=
NCI-H2171 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[3WWlEPTB;Mz6wN|Q1QCEQvF2= NUflWWJmW0GQR1XS
A704 Mm\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS3VGpFUUN3ME2zMlE1OTl2IN88US=> MWTTRW5ITVJ?
DB NWjJXoJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjVNW4zUUN3ME2zMlI2PTd4IN88US=> NVHCS|FWW0GQR1XS
NCI-H719 MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfvTWM2OD1|LkOwN|g1KM7:TR?= MU\TRW5ITVJ?
MC-CAR MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYO4SIxoUUN3ME2zMlU1QDF5IN88US=> M2HWWHNCVkeHUh?=
SIMA NHnnUlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwNUi0NVYh|ryP MVzTRW5ITVJ?
SW872 NUDJXpBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVqyWGc5UUN3ME2zMlc5OTBzIN88US=> MXnTRW5ITVJ?
HCC1187 MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTNwN{izNVUh|ryP MlvMV2FPT0WU
EW-13 NYL6bYp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf6TWM2OD1|LkizOFE4KM7:TR?= NW\HWmFSW0GQR1XS
NCI-SNU-1 MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGGwPZRKSzVyPUSuNlE6QTlizszN M1;xdHNCVkeHUh?=
NCI-H226 NEnLNYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT3NpdKSzVyPUSuN|M3ODZizszN MUDTRW5ITVJ?
RPMI-8866 MoDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTRwM{[wNlkh|ryP Ml;VV2FPT0WU
OCI-AML2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTRwNUWyN{DPxE1? MVPTRW5ITVJ?
LU-65 MoHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvzVmlKSzVyPUSuPVMxOzNizszN M{\HWXNCVkeHUh?=
SK-N-DZ MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml6yTWM2OD13Lk[zOFY2KM7:TR?= MXzTRW5ITVJ?
NB14 M2fwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLKcVhKSzVyPUWuPVcyOzVizszN NF7xeGpUSU6JRWK=
COLO-829 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXmNlBKSzVyPU[uN|M{PTlizszN MVvTRW5ITVJ?
MHH-CALL-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjoV3I3UUN3ME22MlUyPTB6IN88US=> MWDTRW5ITVJ?
NCI-H1770 NELGfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTZwNk[5NFQh|ryP MV\TRW5ITVJ?
ECC4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHHOG1KSzVyPU[uPFIyPzlizszN MUHTRW5ITVJ?
A498 M3HaU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonGTWM2OD14Lki3NVkzKM7:TR?= M3uzTnNCVkeHUh?=
DMS-79 M3vSSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL5TWM2OD15LkC0OVEzKM7:TR?= NHrWbFRUSU6JRWK=
P30-OHK NVvHSI5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPafI5KSzVyPUeuNlE6ODZizszN MlLFV2FPT0WU
D-502MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPp[YZ6UUN3ME23Mlk5OzZizszN NYnBPG13W0GQR1XS
RCC10RGB NXXKPFNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2GxfWlEPTB;OD6wOlI5KM7:TR?= MofxV2FPT0WU
U-698-M MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n1U2lEPTB;OD6yPVIzPiEQvF2= MYHTRW5ITVJ?
BB49-HNC NGS3fHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTlwNEKyOlUh|ryP MlezV2FPT0WU
ES1 NXHnOotlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEWybpBKSzVyPUmuOlg6PTZizszN MnvhV2FPT0WU
MFM-223 NGizd5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrI[ZRKSzVyPUGwMlk6OjdizszN NX3tbJRIW0GQR1XS
C2BBe1 M4fCe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFzLkO1NlMh|ryP M3LLSnNCVkeHUh?=
EB2 Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLiTWM2OD1zMj62PFgyKM7:TR?= MmPRV2FPT0WU
C8166 NG\OSINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HPe2lEPTB;MUOuPFMxOyEQvF2= M2HncnNCVkeHUh?=
ES3 NF[wbHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlj2TWM2OD1zMz65PVc4KM7:TR?= MX\TRW5ITVJ?
NCI-H1650 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NImxb3JKSzVyPUG2MlM4PjVizszN M{i3NXNCVkeHUh?=
Mo-T NWnRNYdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDOTWM2OD1zNz60NFI6KM7:TR?= NHrwdGRUSU6JRWK=
NB7 NXj0cJFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTi[XVFUUN3ME2xO{44PDZ5IN88US=> Mmn5V2FPT0WU
ES7 NYfDeFJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LydmlEPTB;MUmuOVUxPyEQvF2= M120PXNCVkeHUh?=
ES5 Mm\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrWXpRKSzVyPUKxMlc3PzFizszN NFLN[pdUSU6JRWK=
MSTO-211H NG\IfohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJzLki4OVgh|ryP M2fhSnNCVkeHUh?=
U-87-MG NIHpT5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK2b5dKSzVyPUK1MlE6PjZizszN MkTVV2FPT0WU
THP-1 NVSzUGoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIqxWXJKSzVyPUK5MlczODFizszN MU\TRW5ITVJ?
NB10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfYboxKSzVyPUOwMlI3QTRizszN NV7tTmZsW0GQR1XS
NH-12 NIXKRWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7RTWM2OD1|Mz6yNFE4KM7:TR?= MX3TRW5ITVJ?
COLO-824 NXzwXo9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTN2LkGwNFYh|ryP Mlf5V2FPT0WU
SKM-1 M{Dz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTN5Lki0NlIh|ryP NGOz[pRUSU6JRWK=
NCI-H1838 NWPZ[IFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTN6LkO3PVch|ryP MVvTRW5ITVJ?
RL NYD4Tm9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELtb3NKSzVyPUO5MlI1PzdizszN NEn1UG1USU6JRWK=
COLO-800 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DPPWlEPTB;NECuNFc4OyEQvF2= NF\P[4tUSU6JRWK=
KG-1 NFzrVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ToWWlEPTB;NECuPFk2PSEQvF2= NWn4bG5rW0GQR1XS
TUR M{DvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j0cmlEPTB;NEGuOlM6QSEQvF2= NEjV[lJUSU6JRWK=
LNCaP-Clone-FGC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[5NGlEPTB;NEGuPVAyPyEQvF2= M2K2OnNCVkeHUh?=
NCI-H322M NIrU[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rxT2lEPTB;NEKuOVk5PCEQvF2= MUfTRW5ITVJ?
LNCaP  NGrsNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPJTWM2OD17MT6zJI5O MUGyOVUxPTF5NB?=
C4-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHMWXYzUUN3ME24JI5O NGnrZ3IzPTVyNUG3OC=>
JURKAT M3HDVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17jRVI1KGh? Moi0TWM2OD12MU[uOlYhdk1? NYDJdY9GOjR3MUm5PVU>
MOLT-4 NHTneGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HqWVI1KGh? M3fkcGlEPTB;Mki1N{42KG6P MVyyOFUyQTl7NR?=
REH MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHkNlQhcA>? MVTJR|UxRTJ6Nz62PEBvVQ>? M{TM[VI1PTF7OUm1
NALM-6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrxWFEzPCCq MmL0TWM2OD1|NEOzNEBvVQ>? NY\3ZnZTOjR3MUm5PVU>
RS 4;11 MorZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LIXVI1KGh? NGfyTYFKSzVyPUWxPU4xPSCwTR?= M4jVeVI1PTF7OUm1
697 MoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUiyOEBp MnzFTWM2OD1{MUC3MlEhdk1? M2KzPFI1PTF7OUm1
SIL-ALL NG\wUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfuemRzOjRiaB?= MoDaTWM2OD1zOUmuO|chdk1? NI\2cWgzPDVzOUm5OS=>
CEM MkHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXUeo0zPCCq MmfVTWM2OD13Mj6xPEBvVQ>? Mnf4NlQ2OTl7OUW=
P12 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ThWlI1KGh? M374bWlEPTB;M{muNlchdk1? MnSxNlQ2OTl7OUW=
NALM-16 NHjDTFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUOyOEBp M1XKfGlEPTB;OU[uNlghdk1? NX3wXnFGOjR3MUm5PVU>
JURKAT MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX60PEBp NX7wNGE1UUN3ME2xOE45PCCwTR?= NFHBUHUzPDVzOUm5OS=>
MOLT-4 M2Tsemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nmSlQ5KGh? MVfJR|UxRTJ4Lk[gcm0> NXG2dHhMOjR3MUm5PVU>
REH MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XZdVQ5KGh? M2PYZ2lEPTB;NESuO|Ehdk1? M37nOFI1PTF7OUm1
NALM-6 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrCW201QCCq MlLzTWM2OD1{Mz6yOkBvVQ>? MUeyOFUyQTl7NR?=
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C2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlftNU0yODByIH7N MlzxO|IhcA>? NX3rOI1wcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n NHfUeIMzOTJ2MkG4PS=>
CHP-212 MmXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\JVHVmOS1zMkWgcm0> NG\jNVQzPC1zMkCgbC=> MlvobY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= M37hSlIyOTZ7MkSy
IMR-32 MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXmxMVEzPSCwTR?= MWqyOE0yOjBiaB?= NVfWcI9XcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> M4GyO|IyOTZ7MkSy
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SH-SY5Y NXzZTo1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[5ZYcyNTF{NTDuUS=> MoTUNlQuOTJyIHi= MlTGbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MnznNlEyPjl{NEK=
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... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 21 mg/mL (40.25 mM)
エタノール 100 mg/mL (191.69 mM)
<1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

カスタマーフィードバック (10)


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Source Cancer Cell , 2010, 18, 641–654. BI 2536 purchased from Selleck
Method Immunohistochemical analysis
Cell Lines SCID mice
Concentrations
Incubation Time
Results Control tumors grow exponentially, whereas genetic ablation of Cdc20 results in complete tumor regression in about 10 days. In comparison, treatment with taxol, vincristine, and BI2536 only induces partial responses ( Figure C). In agreement with the data observed in vitro, immunohistochemical analysis of samples taken 3 days after the first treatment indicates lack of proliferation (as measured by BrdU incorporation) and massive apoptosis in Cdc20 null cells, whereas all other samples maintain significant levels of proliferation and reduced apoptotic markers ( Figure D)

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Source Nat Cell Biol, 2011, 13, 1265-71. BI 2536 purchased from Selleck
Method cold-stable assay, Immunological methods
Cell Lines RPE1 cells
Concentrations 40 nM
Incubation Time 45 min
Results To examine whether B56-PP2A attenuates the signalling of kinetochore kinases other than Aurora B, we examined Plk1. Remarkably, wash-in of the Plk1 inhibitor BI2536 also restored K-fibres in B56-PP2A-siRNA cells.

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Western blot
Cell Lines NB TICs
Concentrations 10-100 nM
Incubation Time 16/24 h
Results The cyclin-dependent kinase inhibitor p21, a newly identified substrate of PLK1, also accumulated in BI 2536-treated NB TICs (Fig. C). Finally, PLK1 kinase activity was inhibited following treatment of NB TICs with BI 2536, as demonstrated by anti-PLK1 immunoprecipitiation followed by in vitro PLK1 kinase assay ( Fig. D)

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Trypan blue exclusion, Western blot
Cell Lines NB TICs
Concentrations 10/30/100 nmol/L
Incubation Time 24/48/72 h
Results We observed a significant difference in viable cell numbers in BI2536-treated samples, as compared with DMSO (vehicle)-treated cells, at 24 hours posttreatment. The difference became more pronounced with time, such that at 72 hours there were only approximately 20% viable cells following treatment with 10 nmol/L BI 2536 and approximately 2% to 5% viable cells following treatment with 30 and 100 nmol/L as compared with DMSO-treated cells(Fig. A). At 24 hours, BI 2536-treated cells gradually accumulated cleaved PARP, in contrast to DMSO-treated cells, suggesting induction of apoptosis ( Fig. B).

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5-25 mg/kg
Incubation Time 0-24 d
Results As shown in Figure A,tumor growth was significantly inhibited following administration of the third cycle of BI 2536 therapy. When mice were administered 25 mg/ kg weekly on 2 consecutive days for a total of only 2 cycles, tumor growth was inhibited after the second cycle ( Fig. B)

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5 mg/kg
Incubation Time 0-60 d
Results We examined a combination of a low dose of BI 2536 (12.5 mg/kg) with a low dose of irinotecan (10 mg/kg), a topoisomerase inhibitor with demonstrated activity in phase II clinical trials in relapsed NB. Single-agent treatment with low-dose of either BI 2536 or irinotecan was comparably efficacious, resulting in significant growth inhibition, as compared with vehicle-treated animals.

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Source J Invest Dermatol, 2011, 131, 1886–1895. BI 2536 purchased from Selleck
Method MTT assay
Cell Lines M14 cell lines, WM-115 cell lines
Concentrations 1-20 nM
Incubation Time
Results Specific inhibition of Plk-1 using the commercially available inhibitor BI 2536 led to a dose- and time-dependent decrease in human melanoma cell viability.

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Source J Biol Chem, 2012, 287(21), 17088-99. BI 2536 purchased from Selleck
Method Cell death assay
Cell Lines HeLa cells
Concentrations 0 -120 nM
Incubation Time 72 h
Results In HeLa cells lacking GRK5, there was an~4.5-fold decrease in the EC50 of BI 2536-mediated cell death (control shRNA, 18.9 ?.2 nM; GRK5 shRNA, 4.1?.1 nM, n = 6, p < 0.05) (Fig. A). Similar to BI 2536, cells lacking GRK5 were ~4.5-fold more sensitive to GSK461364 compared with control cells (EC50 for control shRNA cells, 17.0 ?4.4 nM;EC50 for GRK5-shRNA cells, 3.8 ?0.7 nM, n = 4, p < 0.05).

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Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 0-10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

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Rating
Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

文献中の引用 (50)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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