BI 2536 化学構造
分子量: 521.66

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Quality Control & MSDS

製品説明

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    PLK製品生物活性の比較
  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjne3JjUUN3ME2wMlAxPzd4IN88US=> MY\TRW5ITVJ?
ACN MnH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HxXWlEPTB;MD6wNFg1OyEQvF2= MnrEV2FPT0WU
TE-8 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7SeYZKSzVyPUCuNFA6PDFizszN Ml\KV2FPT0WU
LC-2-ad MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYOzb2dxUUN3ME2wMlAyODl|IN88US=> NVTPUVJXW0GQR1XS
ALL-PO M4TFdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoexTWM2OD1yLkCxN{DPxE1? M3zLenNCVkeHUh?=
EW-16 NGHDbItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HvT2lEPTB;MD6wNVM{PiEQvF2= M1n2WXNCVkeHUh?=
KM12 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTpTWM2OD1yLkCxN|Q5KM7:TR?= M4PQ[HNCVkeHUh?=
GI-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[3SGlEPTB;MD6wNVM5OyEQvF2= MnLkV2FPT0WU
LS-411N MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHWe3FJUUN3ME2wMlAyPDB5IN88US=> NXvlNmtUW0GQR1XS
ES8 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMEG0PVQh|ryP MmC4V2FPT0WU
SNU-C2B NIH1VmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEG1NlYh|ryP MYXTRW5ITVJ?
CESS NFnXO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEG2NFIh|ryP M{PERXNCVkeHUh?=
697 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoryTWM2OD1yLkCxOlY5KM7:TR?= MlfWV2FPT0WU
NCI-H1963 NX35dYNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvKfoxCUUN3ME2wMlAyPjd|IN88US=> NGW4ZWhUSU6JRWK=
IA-LM NYjnc5BST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X2[mlEPTB;MD6wNVY5QCEQvF2= MYPTRW5ITVJ?
SW954 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7oNYlOUUN3ME2wMlAyPzB3IN88US=> MmfUV2FPT0WU
RL95-2 NFzvRlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEG3N|gh|ryP Ml\xV2FPT0WU
LXF-289 M2HzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i5dGlEPTB;MD6wNVc4KM7:TR?= MoXDV2FPT0WU
OCUB-M NULzT4g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEG4NlYh|ryP NIrEZmpUSU6JRWK=
RKO NEfzOnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M12zXGlEPTB;MD6wNVk5PyEQvF2= M4jhbHNCVkeHUh?=
LOUCY MmnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUKzSmY{UUN3ME2wMlAzODVizszN MV;TRW5ITVJ?
NOS-1 MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfyVZBKSzVyPUCuNFIxQTNizszN MlPQV2FPT0WU
A4-Fuk NVTX[29XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{CxUWlEPTB;MD6wNlIyQCEQvF2= NXrme29xW0GQR1XS
A388 NYjP[2toT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULBeI43UUN3ME2wMlAzOjJ5IN88US=> M{H4ZXNCVkeHUh?=
TE-9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TPVGlEPTB;MD6wNlI3OSEQvF2= M{HTTnNCVkeHUh?=
KURAMOCHI M3vrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DjPGlEPTB;MD6wNlI5PSEQvF2= M13ETXNCVkeHUh?=
KALS-1 M17GV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEKzN|gh|ryP MlfxV2FPT0WU
HOP-62 NIj2RmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLETWM2OD1yLkCyOFIh|ryP NYDmU4NiW0GQR1XS
RPMI-8402 NHO3NYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LjV2lEPTB;MD6wNlUxQCEQvF2= MV7TRW5ITVJ?
TE-1 NE\JeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEK1NVIh|ryP NXG4d4YzW0GQR1XS
CCRF-CEM MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoSzTWM2OD1yLkCyOVQ{KM7:TR?= NFPkNIJUSU6JRWK=
HUTU-80 NUHvXY1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLNTWM2OD1yLkCyOlI1KM7:TR?= NWS0SG0xW0GQR1XS
NCI-H1648 NXzPfZJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrwTWM2OD1yLkCyOlQ4KM7:TR?= MkS5V2FPT0WU
HCE-4 NWPqTVZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkToTWM2OD1yLkCyOlgzKM7:TR?= NEXnbmFUSU6JRWK=
ETK-1 M13ZW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1exe2lEPTB;MD6wNlc{PiEQvF2= Mlz6V2FPT0WU
TE-15 NF62NYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TneWlEPTB;MD6wNlc{QCEQvF2= MlfwV2FPT0WU
BE-13 NFizeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vCV2lEPTB;MD6wNlc1KM7:TR?= MmHtV2FPT0WU
KE-37 M2O0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDTTWM2OD1yLkCyO|QyKM7:TR?= MnP2V2FPT0WU
NCI-H1355 NVvoeHJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTDUYVXUUN3ME2wMlAzPzh|IN88US=> MVLTRW5ITVJ?
TE-11 NXjxTpJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13KPWlEPTB;MD6wNlgxQSEQvF2= M1znW3NCVkeHUh?=
BL-70 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH4TWM2OD1yLkCyPFU4KM7:TR?= MkP1V2FPT0WU
ES6 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnFXYpKSzVyPUCuNFI5QDFizszN Mn6xV2FPT0WU
GT3TKB M2\HTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DHbmlEPTB;MD6wNlk2OyEQvF2= M4n3cnNCVkeHUh?=
LB647-SCLC M4DKXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\G[mI4UUN3ME2wMlA{OTl3IN88US=> NVT0Z5BMW0GQR1XS
NB13 M323VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEOzNVYh|ryP MlXsV2FPT0WU
ST486 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLoR49KSzVyPUCuNFM{OzdizszN MXTTRW5ITVJ?
NCI-H82 M{H1S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT4bHduUUN3ME2wMlA{OzR|IN88US=> MXXTRW5ITVJ?
NTERA-S-cl-D1 M2TZcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLMPG9UUUN3ME2wMlA{Ozl7IN88US=> MXHTRW5ITVJ?
ES4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjIZVNKUUN3ME2wMlA{PDZ|IN88US=> MmHNV2FPT0WU
SK-NEP-1 M3vhdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml6yTWM2OD1yLkCzOFk6KM7:TR?= MWrTRW5ITVJ?
Becker NUKyV|JvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr4N2JKSzVyPUCuNFM2PTVizszN NVXCS5F1W0GQR1XS
A101D MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXoTWM2OD1yLkCzO|Q5KM7:TR?= MWjTRW5ITVJ?
SK-UT-1 Mk\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nTVWlEPTB;MD6wN|c4PCEQvF2= M1izUXNCVkeHUh?=
SW982 NFq1V|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnUU5BKSzVyPUCuNFM4QSEQvF2= NWHOZZdbW0GQR1XS
TE-10 NVLrZXZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PrRWlEPTB;MD6wOFA1PiEQvF2= Mn31V2FPT0WU
OVCAR-4 M2DEbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzrRm84UUN3ME2wMlA1ODV7IN88US=> NX;yXmpTW0GQR1XS
KP-N-YS MnzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XGR2lEPTB;MD6wOFA5PSEQvF2= NFTu[3RUSU6JRWK=
BL-41 M3O1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPpRWVKSzVyPUCuNFQyOjVizszN NF:wS5FUSU6JRWK=
MZ1-PC NH3vN4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrPXmZKSzVyPUCuNFQyOjdizszN MlrWV2FPT0WU
PF-382 MofES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELhSmFKSzVyPUCuNFQyQThizszN NF3M[XJUSU6JRWK=
MOLT-13 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFeyeVJKSzVyPUCuNFQzOzhizszN MV3TRW5ITVJ?
HCC1599 NHHNe4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf6TWM2OD1yLkC0NlU5KM7:TR?= NGLSdXlUSU6JRWK=
IST-MEL1 M2XZOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTYNGpKSzVyPUCuNFQ1PDJizszN NH7BOZFUSU6JRWK=
LU-139 MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMES0OFIh|ryP NHG2XWFUSU6JRWK=
MS-1 NETyV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\JeGlEPTB;MD6wOFcxOSEQvF2= MnTBV2FPT0WU
MFH-ino NH20SFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TPWWlEPTB;MD6wOVAxOyEQvF2= MmTaV2FPT0WU
IMR-5 M4OxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLxbIgyUUN3ME2wMlA2ODJzIN88US=> MmjYV2FPT0WU
TE-5 M1HZXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMEWwOlMh|ryP NHjLU2pUSU6JRWK=
DJM-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDxTWM2OD1yLkC1NVQzKM7:TR?= MV3TRW5ITVJ?
NB17 NXK3b4NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnMTWM2OD1yLkC1NlA4KM7:TR?= M33VUnNCVkeHUh?=
KARPAS-45 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\2TWM2OD1yLkC1N|U5KM7:TR?= NFrhTGtUSU6JRWK=
TGBC1TKB MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEW0NFUh|ryP MnTDV2FPT0WU
ML-2 MoS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEW0NVQh|ryP NVfCRXNSW0GQR1XS
no-10 M2fseWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XrR2lEPTB;MD6wOVQ4PCEQvF2= MkjCV2FPT0WU
CTV-1 M{j4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LKZ2lEPTB;MD6wOVUxOiEQvF2= Mo\GV2FPT0WU
SJSA-1 MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;mWmlEPTB;MD6wOVUzKM7:TR?= NFTQeZRUSU6JRWK=
HC-1 NVriUINLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEW1PVch|ryP M4f4enNCVkeHUh?=
TE-12 M4ntdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2S2SGlEPTB;MD6wOVYyOyEQvF2= NXHKZm5wW0GQR1XS
KY821 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\SPVlKSzVyPUCuNFU3OzJizszN MmjQV2FPT0WU
TALL-1 M4fwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TmOWlEPTB;MD6wOVcxQCEQvF2= MnLlV2FPT0WU
DEL NFL6cWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[zWWlEPTB;MD6wOVcxQSEQvF2= NELXZpBUSU6JRWK=
TE-6 M1TveWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEW3NlIh|ryP MlH6V2FPT0WU
SK-LMS-1 NFu0bGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnKOHdCUUN3ME2wMlA2QDB3IN88US=> M3zYfnNCVkeHUh?=
EW-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HlVmlEPTB;MD6wOVg{PyEQvF2= NWi5NVdCW0GQR1XS
8-MG-BA MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrqTWM2OD1yLkC1PFUyKM7:TR?= MYXTRW5ITVJ?
NALM-6 M1jp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\4OGlEPTB;MD6wOVk4OyEQvF2= M3LmTXNCVkeHUh?=
LB771-HNC NE\UU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\DNIJPUUN3ME2wMlA2QTd7IN88US=> M3zkVXNCVkeHUh?=
HT-144 NVL4[Y5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv3SVI2UUN3ME2wMlA3OTNizszN M3nwN3NCVkeHUh?=
KM-H2 MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvSbohKSzVyPUCuNFYzOjFizszN NETpZllUSU6JRWK=
SF268 NXjaUXVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwME[yPFYh|ryP NEjkcmtUSU6JRWK=
RS4-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwME[zNFQh|ryP MVfTRW5ITVJ?
MHH-PREB-1 M4\HV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XvO2lEPTB;MD6wOlMyQSEQvF2= NWL6cIY6W0GQR1XS
ATN-1 MorwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwME[zOFUh|ryP M2XuPHNCVkeHUh?=
BB30-HNC MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwME[0N|Yh|ryP MXrTRW5ITVJ?
CPC-N NVfhb4puT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInJ[41KSzVyPUCuNFY2OjRizszN NH[0TnRUSU6JRWK=
NB1 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLMNVFMUUN3ME2wMlA3PjF|IN88US=> M4LufnNCVkeHUh?=
KS-1 NF[1SGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGGybm1KSzVyPUCuNFY4PDhizszN M{T0[nNCVkeHUh?=
RXF393 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwME[3OlQh|ryP MYnTRW5ITVJ?
IST-SL2 M4nq[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjVTWM2OD1yLkC3NFA1KM7:TR?= NGTTdYdUSU6JRWK=
GI-ME-N NIfjfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrFVZRKSzVyPUCuNFczQDZizszN M2XFfHNCVkeHUh?=
VA-ES-BJ MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHmyS|VKSzVyPUCuNFc1PzVizszN MWjTRW5ITVJ?
NCI-H1581 NWfJc5NiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEe0O|gh|ryP MVfTRW5ITVJ?
U-266 NF\5TFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEe0PVch|ryP MlHrV2FPT0WU
DMS-114 MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDj[FJKSzVyPUCuNFc2OjhizszN NFvV[2lUSU6JRWK=
NCI-H187 M17NPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L4bWlEPTB;MD6wO|czPiEQvF2= NXPaZmJVW0GQR1XS
SW962 MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnCTWM2OD1yLkC3PFM6KM7:TR?= M2rpfXNCVkeHUh?=
MONO-MAC-6 MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoO3TWM2OD1yLkC3PVg3KM7:TR?= M1jPS3NCVkeHUh?=
MOLT-16 NWHBWoFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfHTWM2OD1yLkC4NVIyKM7:TR?= NGPQW|RUSU6JRWK=
KNS-42 M2HWOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorTTWM2OD1yLkC4NVYyKM7:TR?= Mnn0V2FPT0WU
CMK NGDqPYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEiyNlUh|ryP MXTTRW5ITVJ?
Ramos-2G6-4C10 NH3EO5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfsbnN3UUN3ME2wMlA5OjJ3IN88US=> M2eyNHNCVkeHUh?=
Daudi MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrhTWM2OD1yLkC4NlU3KM7:TR?= NED0V4xUSU6JRWK=
NCI-H510A MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nId2lEPTB;MD6wPFM{PiEQvF2= NUjscokxW0GQR1XS
LB831-BLC Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEi1OlEh|ryP NVrOcWFCW0GQR1XS
HEL NXXK[pI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMEi2Olgh|ryP NHXWclhUSU6JRWK=
LU-134-A NI\TbZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L6b2lEPTB;MD6wPFcxQCEQvF2= MoLpV2FPT0WU
NCI-H1694 MnO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LxWWlEPTB;MD6wPFc1PCEQvF2= NXfvWJBmW0GQR1XS
KGN M13ab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEi3OVkh|ryP M1riNnNCVkeHUh?=
A253 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEi4NlIh|ryP M17sbnNCVkeHUh?=
DG-75 NWfHWo9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3hTWM2OD1yLkC4PVIzKM7:TR?= NFPMfFRUSU6JRWK=
MOLT-4 M1\GRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEi5PFMh|ryP M2PQRnNCVkeHUh?=
NCI-SNU-5 MnfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEmyOVgh|ryP MVzTRW5ITVJ?
ONS-76 NX\KSYdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlflTWM2OD1yLkC5Nlc3KM7:TR?= M{X0OXNCVkeHUh?=
NCI-H446 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEm0OlIh|ryP NIT2V2JUSU6JRWK=
COR-L279 NXj4SXU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH3TWM2OD1yLkC5OVU3KM7:TR?= M{n5fnNCVkeHUh?=
Calu-6 NVvkSo4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEm1PVgh|ryP MV\TRW5ITVJ?
BC-3 Mmm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEm2OlIh|ryP MXfTRW5ITVJ?
NCI-H2126 MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nzZWlEPTB;MD6wPVc6OSEQvF2= M13OTXNCVkeHUh?=
NCI-H1882 M2XxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGO1eldKSzVyPUCuNFk5ODlizszN M4[wZnNCVkeHUh?=
BB65-RCC MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMUCyPVQh|ryP NH7ZTIVUSU6JRWK=
DU-4475 M4L5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnBS3NKSzVyPUCuNVA1ODdizszN NG\VcZlUSU6JRWK=
NCI-H526 MkC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL2Z3pKSzVyPUCuNVA1PCEQvF2= MYnTRW5ITVJ?
NEC8 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMUC1NlUh|ryP MlHIV2FPT0WU
NCI-H1304 M{DRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHJSpVKSzVyPUCuNVA2QTRizszN M{[5O3NCVkeHUh?=
L-540 MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\VTmtKSzVyPUCuNVA4ODhizszN MVvTRW5ITVJ?
NCI-SNU-16 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\KOWlEPTB;MD6xNFc1OiEQvF2= M3fMSXNCVkeHUh?=
HD-MY-Z NFLrTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMUC4OVYh|ryP NYD6b4NPW0GQR1XS
K-562 NFWw[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjKUpFKSzVyPUCuNVA5PThizszN NELGWVlUSU6JRWK=
JAR MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[0ZWlEPTB;MD6xNFkzPSEQvF2= MXjTRW5ITVJ?
MZ2-MEL MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMUGwOUDPxE1? NHjHe2xUSU6JRWK=
L-363 M4rFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjiTWM2OD1yLkGxNFc6KM7:TR?= NHXFcHBUSU6JRWK=
BV-173 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvZWZZKSzVyPUCuNVEzPDNizszN MlrPV2FPT0WU
NCI-H524 NYjRcFRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPBcFlZUUN3ME2wMlEyOjd2IN88US=> NYPEbFZbW0GQR1XS
EoL-1-cell MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMUG2O|Ih|ryP MVLTRW5ITVJ?
K052 MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHRTWM2OD1yLkGxO|EzKM7:TR?= MmrlV2FPT0WU
TK10 M{SwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HQSWlEPTB;MD6xNVczQCEQvF2= NFPkZY9USU6JRWK=
KU812 NILwNmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlqzTWM2OD1yLkGyNFQ1KM7:TR?= NHHz[mpUSU6JRWK=
RPMI-8226 M1K0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\jTWM2OD1yLkGyNFUzKM7:TR?= MUXTRW5ITVJ?
MZ7-mel MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDGTWM2OD1yLkGyNlM4KM7:TR?= MUTTRW5ITVJ?
SK-PN-DW M2LZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[wTWM2OD1yLkGyNlg4KM7:TR?= NHzrd|VUSU6JRWK=
SR NV\MdlVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHqTWM2OD1yLkGyOFQyKM7:TR?= M2T4SnNCVkeHUh?=
RPMI-6666 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvtO3h6UUN3ME2wMlEzPzR|IN88US=> NXrS[4txW0GQR1XS
no-11 MnLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7TVFBKSzVyPUCuNVI5PjlizszN NIHIdnpUSU6JRWK=
EW-3 NVfoNJZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXQUWdUUUN3ME2wMlEzQDl|IN88US=> MnPyV2FPT0WU
LAMA-84 NXXCPZNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMUOxPFch|ryP NVLDPI02W0GQR1XS
HT NVHiNlhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH4XI5bUUN3ME2wMlE{PTd2IN88US=> MYjTRW5ITVJ?
KP-N-RT-BM-1 NEPjU|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMUO2NVIh|ryP NYS4cWxWW0GQR1XS
NCI-H747 Mmf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG3TWM2OD1yLkGzO{DPxE1? M3\TfnNCVkeHUh?=
NCCIT NX30ZXgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPke4Z[UUN3ME2wMlE{QTN7IN88US=> MmPVV2FPT0WU
MLMA NUPrOI1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LRRWlEPTB;MD6xOFE3PyEQvF2= NFqxdFhUSU6JRWK=
LP-1 M4jFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoOwTWM2OD1yLkG0NlQh|ryP MkfOV2FPT0WU
CAL-148 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnyTWM2OD1yLkG0OFg{KM7:TR?= M2mzVXNCVkeHUh?=
GB-1 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMUS1NlYh|ryP NFe2cWFUSU6JRWK=
COR-L88 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LKbWlEPTB;MD6xOFgxOiEQvF2= MYXTRW5ITVJ?
NKM-1 NX7yeml{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\JcmVKSzVyPUCuNVQ6ODZizszN NWLXRnc1W0GQR1XS
NB5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrm[olKSzVyPUCuNVU1PjJizszN NVO2V3NiW0GQR1XS
SH-4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMUW0OlYh|ryP NIjNPJpUSU6JRWK=
EM-2 M1nBcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXGPIxKSzVyPUCuNVU1PjdizszN NISzd2VUSU6JRWK=
TGBC24TKB NIm0[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMUW2OVkh|ryP NV3TWW1IW0GQR1XS
SCLC-21H MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zGSGlEPTB;MD6xOVcxOiEQvF2= M2K5XnNCVkeHUh?=
COLO-684 NFjDTVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O0XWlEPTB;MD6xOVczOSEQvF2= Mlv6V2FPT0WU
KINGS-1 NHnLbWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnxN2dFUUN3ME2wMlE2QTFizszN M4HBWXNCVkeHUh?=
LS-123 NYno[|VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMUW5NVch|ryP MoHIV2FPT0WU
MC116 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;BTWM2OD1yLkG2NVU5KM7:TR?= MVHTRW5ITVJ?
SU-DHL-1 NV3nWVRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP6XVIzUUN3ME2wMlE3OjB4IN88US=> MknYV2FPT0WU
NCI-H64 NIflSmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnryTWM2OD1yLkG2N|Q4KM7:TR?= M1XLdnNCVkeHUh?=
HCE-T MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTyTWM2OD1yLkG2OVA1KM7:TR?= MXXTRW5ITVJ?
LOXIMVI MlnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMU[5OFkh|ryP NGe5W3BUSU6JRWK=
ARH-77 M1nCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz0XHZKSzVyPUCuNVc{PzlizszN NHrtSIJUSU6JRWK=
DOHH-2 NXe1SZNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMUe2O|Ih|ryP M1;uSXNCVkeHUh?=
COLO-320-HSR NHS2SJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMUixOVQh|ryP MWHTRW5ITVJ?
NB6 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPLTWM2OD1yLkG4OVY3KM7:TR?= M3G0[XNCVkeHUh?=
L-428 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i0VmlEPTB;MD6xPFgyOyEQvF2= NUXWfFFsW0GQR1XS
SNB75 NGTic|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrjO29KSzVyPUCuNVg5OjRizszN NXWwUJZoW0GQR1XS
NCI-H2141 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7jTWM2OD1yLkG5NFEyKM7:TR?= Mk\PV2FPT0WU
KARPAS-299 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMUmyOFEh|ryP NV\ZWlJsW0GQR1XS
LC4-1 MnLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj4[ZBKSzVyPUCuNVk2ODJizszN NFXKOG5USU6JRWK=
UACC-257 MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3Ce4N7UUN3ME2wMlE6QTR5IN88US=> NUnE[HE5W0GQR1XS
EVSA-T MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnm[VBKSzVyPUCuNlA{OTJizszN MlSxV2FPT0WU
JiyoyeP-2003 MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMkC0O|ch|ryP NV3ORVB{W0GQR1XS
NCI-H720 M2jifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LlUWlEPTB;MD6yNFUzPSEQvF2= MkDEV2FPT0WU
GAK M1v0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnWbmw2UUN3ME2wMlIyOTh7IN88US=> NEDpWVdUSU6JRWK=
HH NED4ellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfTTWM2OD1yLkKxOFA2KM7:TR?= NWfzTWJFW0GQR1XS
NCI-H1436 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjUZWxVUUN3ME2wMlIyPDZ2IN88US=> NHvVUmJUSU6JRWK=
GR-ST NILjSG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHFTWM2OD1yLkKxOFg5KM7:TR?= NH25PXlUSU6JRWK=
BC-1 M{m5UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTQXlRKSzVyPUCuNlI3OTZizszN MYDTRW5ITVJ?
SIG-M5 MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37acGlEPTB;MD6yNlczPyEQvF2= Ml3HV2FPT0WU
NCI-H345 NIracIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMkO4NFUh|ryP NFjYRXhUSU6JRWK=
OPM-2 NEfGepNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jGVmlEPTB;MD6yN|g5OiEQvF2= Mmr2V2FPT0WU
LB1047-RCC MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMkS0NUDPxE1? NEX3fYVUSU6JRWK=
CTB-1 NILi[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDnTWM2OD1yLkK0OFk{KM7:TR?= M3jreHNCVkeHUh?=
A3-KAW NGTBTZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMkWzOFEh|ryP MYHTRW5ITVJ?
SF126 NHTxZYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX33TmZWUUN3ME2wMlI2Ozh|IN88US=> NIXweWtUSU6JRWK=
KARPAS-422 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX25RZhEUUN3ME2wMlI2PDN3IN88US=> NELibGZUSU6JRWK=
MEG-01 M{XVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMkW2O|Mh|ryP NHfnW3RUSU6JRWK=
NCI-H209 NHvqSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TqV2lEPTB;MD6yOlM4PCEQvF2= NIPkT3RUSU6JRWK=
SBC-1 NVqzOHNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDmTJU5UUN3ME2wMlI3PSEQvF2= MVnTRW5ITVJ?
K5 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrnd3VKSzVyPUCuNlY6QDRizszN MkniV2FPT0WU
QIMR-WIL M2nadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMkexOVUh|ryP NV7KNXpLW0GQR1XS
NMC-G1 MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\1b2lEPTB;MD6yPFIyPyEQvF2= NFLQSVhUSU6JRWK=
IST-MES1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnuO2xKSzVyPUCuNlkzOzhizszN NXTFXnI3W0GQR1XS
SW684 NYrT[lFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvqeINbUUN3ME2wMlMxODR5IN88US=> NHO4TGJUSU6JRWK=
MV-4-11 NE\wR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELqbnJKSzVyPUCuN|A4QDhizszN NV3IS|J6W0GQR1XS
LAN-6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nvZ2lEPTB;MD6zNVU4OiEQvF2= MkexV2FPT0WU
RH-1 M1S2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LtWGlEPTB;MD6zNVg4OSEQvF2= NF3u[3dUSU6JRWK=
CP66-MEL NXv6U4UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwM{G4O|gh|ryP NF6wOHhUSU6JRWK=
EC-GI-10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwM{K5PFch|ryP NHPIdphUSU6JRWK=
GDM-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\JVoFKSzVyPUCuN|MxPTlizszN NVXpTY9iW0GQR1XS
IST-SL1 M4O5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvMSoJKSzVyPUCuN|Q6OTRizszN NYqw[XlIW0GQR1XS
KMOE-2 M3LYXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrV[opKSzVyPUCuN|UyPzVizszN NXTEPFI1W0GQR1XS
OS-RC-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\VZ|FKSzVyPUCuN|U2PDRizszN MWjTRW5ITVJ?
HDLM-2 M4j5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy0WoRNUUN3ME2wMlM4QDF2IN88US=> MWnTRW5ITVJ?
DSH1 MkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLITWM2OD1yLkO4OlMyKM7:TR?= MUPTRW5ITVJ?
LS-1034 NXLaeHdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHyUWRxUUN3ME2wMlM5QTV2IN88US=> MkTDV2FPT0WU
LB373-MEL-D MoniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwM{mxPVch|ryP NX;oNnBMW0GQR1XS
GOTO M4XLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjWe5BiUUN3ME2wMlQzOTF6IN88US=> M1zPSXNCVkeHUh?=
MRK-nu-1 MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;sUWlEPTB;MD60NlIxPSEQvF2= NFq3c4ZUSU6JRWK=
SK-MM-2 MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnxNYg{UUN3ME2wMlQ{PDR{IN88US=> NVnOXVV{W0GQR1XS
BOKU Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\vTWM2OD1yLkSzO|kzKM7:TR?= NUD1V4tUW0GQR1XS
NOMO-1 NGjo[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHiSHpPUUN3ME2wMlQ{QDZizszN M2SzcnNCVkeHUh?=
J-RT3-T3-5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrnbm9yUUN3ME2wMlQ1QDd6IN88US=> MWPTRW5ITVJ?
COLO-668 NIfmOYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPCT|NoUUN3ME2wMlQ2PjZ6IN88US=> NFXuUpZUSU6JRWK=
SF539 NWTXeo5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj6Z5ZFUUN3ME2wMlQ5Pjh2IN88US=> NIrnRpRUSU6JRWK=
LB2518-MEL NXXmWlNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXtO3ZDUUN3ME2wMlQ6PzB|IN88US=> NH3YXYxUSU6JRWK=
TE-441-T Mn2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPrN21JUUN3ME2wMlUxOTJizszN M4XufXNCVkeHUh?=
MDA-MB-134-VI NEfrT41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfyTWM2OD1yLkWwPVIyKM7:TR?= M3PGcXNCVkeHUh?=
SCC-3 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLNfI5KSzVyPUCuOVE5PzNizszN MYLTRW5ITVJ?
KLE MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHLVplOUUN3ME2wMlUzOTdzIN88US=> MUjTRW5ITVJ?
LB2241-RCC M3P2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITCPWNKSzVyPUCuOVI2OjVizszN NHT2VYZUSU6JRWK=
NCI-H1417 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrjV3BKSzVyPUCuOVM1OzVizszN MnP0V2FPT0WU
NCI-H2081 M1TJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlThTWM2OD1yLkW4OlEyKM7:TR?= NGPZ[IVUSU6JRWK=
NCI-H1522 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzyN|VKSzVyPUCuOVk{QDNizszN NGrhdolUSU6JRWK=
NCI-H889 M13nZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjKOm1KSzVyPUCuOVk5PDRizszN M2\sbnNCVkeHUh?=
CGTH-W-1 M1zGS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwNkC3OVUh|ryP MoDMV2FPT0WU
EB-3 NITEToZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHUe2NKSzVyPUCuOlEyPTNizszN M2S1NnNCVkeHUh?=
D-336MG NF;JVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTuNFhNUUN3ME2wMlYyPzlzIN88US=> NVy2NYhFW0GQR1XS
LC-1F NFrQ[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXsTWM2OD1yLk[yOVkzKM7:TR?= M4fJUHNCVkeHUh?=
MHH-NB-11 Mn7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHkN5FKSzVyPUCuOlM5ODFizszN MXXTRW5ITVJ?
SK-N-FI MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTiTopUUUN3ME2wMlY{QTFizszN MnXvV2FPT0WU
NCI-H69 MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETuUItKSzVyPUCuOlQ5PzlizszN M1PoUHNCVkeHUh?=
SCH M2HO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv4TWM2OD1yLk[2NFI{KM7:TR?= NEjLT3lUSU6JRWK=
LS-513 NY\KO4tuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;QR2RKSzVyPUCuOlczPTlizszN NXyx[olXW0GQR1XS
CP67-MEL M1rKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwNke1PVYh|ryP MVrTRW5ITVJ?
GCIY M2jzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL4TWM2OD1yLkewN|Y{KM7:TR?= Ml7MV2FPT0WU
SHP-77 NEHxUXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwN{C3N|Qh|ryP NX3vOG9KW0GQR1XS
EHEB NGSyT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LUU2lEPTB;MD63NVg2PCEQvF2= MkDXV2FPT0WU
D-247MG NEP6boJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\ObWlEPTB;MD63N|I{OiEQvF2= NEfkbZVUSU6JRWK=
Raji M{XLe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D5[mlEPTB;MD63OFk5QSEQvF2= M{LnT3NCVkeHUh?=
MPP-89 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XCdmlEPTB;MD63OVk4QCEQvF2= MV3TRW5ITVJ?
EKVX NHvMVm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HqZmlEPTB;MD63PVA4OyEQvF2= MUPTRW5ITVJ?
HCC2218 M174VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwN{mxN|Eh|ryP MlWzV2FPT0WU
KNS-81-FD MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{SzcGlEPTB;MD64NVAyOSEQvF2= NXuzU4NEW0GQR1XS
HCC2157 Mnf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3senhWUUN3ME2wMlg1QTVzIN88US=> MoX6V2FPT0WU
BT-474 MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MluyTWM2OD1yLki4PFU1KM7:TR?= NXHvXY5WW0GQR1XS
NCI-H748 MoXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjmXoFKSzVyPUCuPVEzKM7:TR?= NYnjOGhQW0GQR1XS
EW-24 NGXh[|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwOUKwNFIh|ryP MXvTRW5ITVJ?
D-263MG M{nZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\rdY9KSzVyPUCuPVQ2OTJizszN MXzTRW5ITVJ?
OMC-1 NUHPU2xZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjSNpNrUUN3ME2wMlk3Ozd|IN88US=> NHnjdJBUSU6JRWK=
NCI-H2196 M33LTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnmU5pKSzVyPUCuPVc4PzdizszN NIjaNpVUSU6JRWK=
HAL-01 NX3UVmNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwOUm4O|Ih|ryP Ml74V2FPT0WU
NCI-H2107 NGfORpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTMVmNKSzVyPUGuNFE5PTRizszN NUfpfWNbW0GQR1XS
LB996-RCC NGPwNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\ENnBEUUN3ME2xMlA5ODVzIN88US=> MnTKV2FPT0WU
NCI-H1395 NHrRT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILqbZZKSzVyPUGuNVA3PyEQvF2= NETVW2pUSU6JRWK=
CHP-126 NFyxbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonrTWM2OD1zLkG2NVk6KM7:TR?= M13Fd3NCVkeHUh?=
NB69 M1;3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P1XWlEPTB;MT6yOlE1QCEQvF2= MlHjV2FPT0WU
CAS-1 MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPDTWM2OD1zLkO0NlMyKM7:TR?= NY\6fINOW0GQR1XS
JVM-3 NGTUc5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki3TWM2OD1zLkS3PFU2KM7:TR?= MV7TRW5ITVJ?
DMS-153 MkTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTaeXVlUUN3ME2xMlU4Pjd2IN88US=> NVy5XFNUW0GQR1XS
SK-MEL-2 NGPqbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfBTWM2OD1zLkexO|g6KM7:TR?= MXTTRW5ITVJ?
NCI-H1155 M{PvOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3UTWM2OD1zLkezOlc3KM7:TR?= M1HG[nNCVkeHUh?=
NCI-H1092 NIfJXWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXP[HNqUUN3ME2xMlc3OTh{IN88US=> NFvEXJpUSU6JRWK=
LU-165 MoDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvnVnFKSzVyPUGuPFY1PzZizszN MVXTRW5ITVJ?
HL-60 MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C5dWlEPTB;MT65PVkxQCEQvF2= NVr4eZJPW0GQR1XS
REH M3Wwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7U[WFKSzVyPUKuNFA2QDJizszN M2G3dnNCVkeHUh?=
JVM-2 NILwU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJwME[xN|Uh|ryP NUTiSWl6W0GQR1XS
MN-60 MoPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvVTWM2OD1{LkG3N|A5KM7:TR?= MVXTRW5ITVJ?
SCC-15 M1zBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJwMkCyO{DPxE1? MmjQV2FPT0WU
SNU-C1 MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXGTWM2OD1{LkKxN|Q{KM7:TR?= MnzXV2FPT0WU
SK-MEL-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;sNWlEPTB;Mj6zNlA1PyEQvF2= M4P6U3NCVkeHUh?=
TGW NEPmZ2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz1TWM2OD1{LkO1NFI4KM7:TR?= MVnTRW5ITVJ?
CA46 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrwRZpKSzVyPUKuO|U6PjdizszN MWLTRW5ITVJ?
NCI-H23 M{KzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fLfGlEPTB;Mj64NFc6OSEQvF2= NX3SXGZTW0GQR1XS
MMAC-SF MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDkNnZrUUN3ME2yMlg3PjJ6IN88US=> MoHsV2FPT0WU
NCI-H2171 M2myRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\VTWM2OD1|LkCzOFQ5KM7:TR?= M1HhWXNCVkeHUh?=
A704 M33kemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLzb|hKSzVyPUOuNVQyQTRizszN MmLiV2FPT0WU
DB NYWyWnJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrl[FNKSzVyPUOuNlU2PzZizszN NXjPSIhzW0GQR1XS
NCI-H719 MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTNwM{CzPFQh|ryP M{jEdnNCVkeHUh?=
MC-CAR MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3XeY5VUUN3ME2zMlU1QDF5IN88US=> MY\TRW5ITVJ?
SIMA M2iyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLxTWM2OD1|LkW4OFE3KM7:TR?= MYHTRW5ITVJ?
SW872 M2LB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjhT4tqUUN3ME2zMlc5OTBzIN88US=> NGHP[nhUSU6JRWK=
HCC1187 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjSTWM2OD1|Lke4N|E2KM7:TR?= MYrTRW5ITVJ?
EW-13 NGr5SnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\ybWhmUUN3ME2zMlg{PDF5IN88US=> NV;Sbo1kW0GQR1XS
NCI-SNU-1 NVj2XplVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XCVWlEPTB;ND6yNVk6QSEQvF2= NVHhfHdSW0GQR1XS
NCI-H226 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTRwM{O2NFYh|ryP MVzTRW5ITVJ?
RPMI-8866 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTRwM{[wNlkh|ryP NULZeY9sW0GQR1XS
OCI-AML2 NYraNYF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTxTWM2OD12LkW1NlMh|ryP MYnTRW5ITVJ?
LU-65 NHfqblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTRwOUOwN|Mh|ryP M3rPfHNCVkeHUh?=
SK-N-DZ MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fV[mlEPTB;NT62N|Q3PSEQvF2= MlfmV2FPT0WU
NB14 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnwbpdFUUN3ME21Mlk4OTN3IN88US=> MlrhV2FPT0WU
COLO-829 M{\RR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u1cmlEPTB;Nj6zN|M2QSEQvF2= MkKyV2FPT0WU
MHH-CALL-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\6ZmtKSzVyPU[uOVE2ODhizszN NHXUOFVUSU6JRWK=
NCI-H1770 NUHt[pVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTZwNk[5NFQh|ryP NV;nUHA6W0GQR1XS
ECC4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TZWGlEPTB;Nj64NlE4QSEQvF2= M4\EWHNCVkeHUh?=
A498 MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLy[5ZFUUN3ME22Mlg4OTl{IN88US=> NWT4TIhNW0GQR1XS
DMS-79 NEDMRZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4mw[WlEPTB;Nz6wOFUyOiEQvF2= MnfSV2FPT0WU
P30-OHK MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\mTVlMUUN3ME23MlIyQTB4IN88US=> MXXTRW5ITVJ?
D-502MG NIjze|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;MWGlEPTB;Nz65PFM3KM7:TR?= MkeyV2FPT0WU
RCC10RGB M4P2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDBTWM2OD16LkC2Nlgh|ryP MmjoV2FPT0WU
U-698-M NWLx[YExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRThwMkmyNlYh|ryP M3q0[nNCVkeHUh?=
BB49-HNC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTlwNEKyOlUh|ryP NUflUZpRW0GQR1XS
ES1 MmTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHaTWM2OD17Lk[4PVU3KM7:TR?= MnrSV2FPT0WU
MFM-223 Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjkXIVyUUN3ME2xNE46QTJ5IN88US=> MV\TRW5ITVJ?
C2BBe1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjhNoVKSzVyPUGxMlM2OjNizszN MnzvV2FPT0WU
EB2 M3HHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTF{Lk[4PFEh|ryP MUnTRW5ITVJ?
C8166 NUnDboxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnWSmJCUUN3ME2xN{45OzB|IN88US=> NEXneGFUSU6JRWK=
ES3 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nENWlEPTB;MUOuPVk4PyEQvF2= MUXTRW5ITVJ?
NCI-H1650 MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG4SnhKSzVyPUG2MlM4PjVizszN M{PMUHNCVkeHUh?=
Mo-T M37lNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTF5LkSwNlkh|ryP MoiwV2FPT0WU
NB7 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf2TWM2OD1zNz63OFY4KM7:TR?= MnnnV2FPT0WU
ES7 NXfSVWZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;XbZRbUUN3ME2xPU42PTB5IN88US=> MmWwV2FPT0WU
ES5 NELJSnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojnTWM2OD1{MT63OlcyKM7:TR?= NWTncYlpW0GQR1XS
MSTO-211H MoniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HiemlEPTB;MkGuPFg2QCEQvF2= NIHWboxUSU6JRWK=
U-87-MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj1TWM2OD1{NT6xPVY3KM7:TR?= M2TL[XNCVkeHUh?=
THP-1 NV;M[Yh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TvWmlEPTB;MkmuO|IxOSEQvF2= NEnCc|lUSU6JRWK=
NB10 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD2WplKSzVyPUOwMlI3QTRizszN NIT2TVFUSU6JRWK=
NH-12 NIPFOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rSeWlEPTB;M{OuNlAyPyEQvF2= NFjkfJpUSU6JRWK=
COLO-824 NE\3UY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XneWlEPTB;M{SuNVAxPiEQvF2= NGLtRWhUSU6JRWK=
SKM-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HmTWlEPTB;M{euPFQzOiEQvF2= MofEV2FPT0WU
NCI-H1838 MlLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr0TWM2OD1|OD6zO|k4KM7:TR?= MVLTRW5ITVJ?
RL MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITHdIFKSzVyPUO5MlI1PzdizszN MmO2V2FPT0WU
COLO-800 MlXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTRyLkC3O|Mh|ryP M2\ObnNCVkeHUh?=
KG-1 M3fkXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTRyLki5OVUh|ryP NUfy[Gl[W0GQR1XS
TUR NXfuXotrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTpbG5{UUN3ME20NU43Ozl7IN88US=> MWfTRW5ITVJ?
LNCaP-Clone-FGC NE[wSXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[zTmtKSzVyPUSxMlkxOTdizszN NHPPNZFUSU6JRWK=
NCI-H322M M4HHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;5No1KSzVyPUSyMlU6QDRizszN NVS3e4FMW0GQR1XS
LNCaP  Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\tOmlEPTB;OUGuN{BvVQ>? NVO2ZXVxOjV3MEWxO|Q>
C4-2 MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRThibl2= NHywRZEzPTVyNUG3OC=>
JURKAT MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPMfIQzPCCq MWHJR|UxRTRzNj62OkBvVQ>? M1;tblI1PTF7OUm1
MOLT-4 NHLzXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWCyOEBp MoXMTWM2OD1{OEWzMlUhdk1? MnruNlQ2OTl7OUW=
REH MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUiyOEBp MYHJR|UxRTJ6Nz62PEBvVQ>? NInlR5YzPDVzOUm5OS=>
NALM-6 NUiyOYdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX[yOEBp NGf0RpFKSzVyPUO0N|MxKG6P NG\ZPY4zPDVzOUm5OS=>
RS 4;11 M1HZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP0[44zPCCq NEHGfXhKSzVyPUWxPU4xPSCwTR?= MlywNlQ2OTl7OUW=
697 Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u5O|I1KGh? MoCxTWM2OD1{MUC3MlEhdk1? MVWyOFUyQTl7NR?=
SIL-ALL M2XoVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTSNlQhcA>? M4PQWGlEPTB;MUm5Mlc4KG6P MVqyOFUyQTl7NR?=
CEM NHXnO|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfPT4YzPCCq Mn\jTWM2OD13Mj6xPEBvVQ>? MX2yOFUyQTl7NR?=
P12 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV:yOEBp NHfYd5pKSzVyPUO5MlI4KG6P MnzqNlQ2OTl7OUW=
NALM-16 M4\MV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;BeGwxOjRiaB?= NIT2SnBKSzVyPUm2MlI5KG6P M3LVcVI1PTF7OUm1
JURKAT MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPmOFghcA>? M4Lu[mlEPTB;MUSuPFQhdk1? M3Wxd|I1PTF7OUm1
MOLT-4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnFWmV4PDhiaB?= MULJR|UxRTJ4Lk[gcm0> M3n6cFI1PTF7OUm1
REH M1vWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPIRmQ1QCCq MUfJR|UxRTR2LkexJI5O MVyyOFUyQTl7NR?=
NALM-6 NXfDO4hMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYC0PEBp M1nSOWlEPTB;MkOuNlYhdk1? MmqxNlQ2OTl7OUW=
RS 4;11 NYDOVpFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHkOFghcA>? M1jNc2lEPTB;MU[0MlI5KG6P NWK1S4I4OjR3MUm5PVU>
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LNCaP  Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXuc3dFVVOR MVjJR|Ux6oj:N{Wgcm0> MmLCNlM5QDR2Mki=
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CHP-212 MorUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrNOnkyNTF{NTDuUS=> MmPSNlQuOTJyIHi= NIL1bGxqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NYXZWnJSOjFzNkmyOFI>
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SH-EP M1PvWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvoNU0yOjVibl2= M4f2VFI1NTF{MDDo M{XvUIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NWq3[GhmOjFzNkmyOFI>
SH-SY5Y NFT3fnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfpS3MyNTF{NTDuUS=> MYWyOE0yOjBiaB?= M4\CSYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NH7FSlAzOTF4OUK0Ni=>
SK-N-AS NIiwR3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT4NU0yOjVibl2= M1Kw[FI1NTF{MDDo MlvmbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MV:yNVE3QTJ2Mh?=
SK-N-BE NVzWVldJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLsPJAyNTF{NTDuUS=> NIPuVJIzPC1zMkCgbC=> Mk\XbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NILQNG0zOTF4OUK0Ni=>
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CAL62 NWnXe|hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXmTYZKOC5zLUGwNEBvVQ>? MUG3NkBp Ml7LSG1UVw>? M2i5bWVEPTB;MT60JI5O MX6xPVIzOzV3Mx?=
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... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 21 mg/mL (40.25 mM)
エタノール 100 mg/mL (191.69 mM)
<1 mg/mL (<1 mM)
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

文献中の引用 (52)

Frequently Asked Questions

  • Question 1
    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

    Answer: For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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