BI 2536

BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。

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電話番号: + 81 3-5632-9610mail@cosmobio.co.jp

BI 2536 化学構造
分子量: 521.66

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製品説明

  • Compare PLK Inhibitors
    PLK製品生物活性の比較
  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 M3Hlcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrNPHpKSzVyPUCuNFA4PzZizszN MkLGV2FPT0WU
ACN NXTmO5hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGm5Z|lKSzVyPUCuNFA5PDNizszN NYGyeHl2W0GQR1XS
TE-8 NHXKUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfTTodKSzVyPUCuNFA6PDFizszN NHzBRm5USU6JRWK=
LC-2-ad NHL4WmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzFNJlbUUN3ME2wMlAyODl|IN88US=> MmDFV2FPT0WU
ALL-PO MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEGzJO69VQ>? MWfTRW5ITVJ?
EW-16 M3HBSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17ocGlEPTB;MD6wNVM{PiEQvF2= MVHTRW5ITVJ?
KM12 M{XhO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf2OmhKSzVyPUCuNFE{PDhizszN Ml7HV2FPT0WU
GI-1 NXfaW3h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMEGzPFMh|ryP MXjTRW5ITVJ?
LS-411N MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGntNHNKSzVyPUCuNFE1ODdizszN M3;IcHNCVkeHUh?=
ES8 M3j5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEG0PVQh|ryP NVv6WFlYW0GQR1XS
SNU-C2B NVXrdY5pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzlTWM2OD1yLkCxOVI3KM7:TR?= MkG4V2FPT0WU
CESS M2PIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEG2NFIh|ryP NWrzZWNmW0GQR1XS
697 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTaTWM2OD1yLkCxOlY5KM7:TR?= M13BXnNCVkeHUh?=
NCI-H1963 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPtZYhKSzVyPUCuNFE3PzNizszN M2L5bHNCVkeHUh?=
IA-LM MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjET4x4UUN3ME2wMlAyPjh6IN88US=> NXS0VGVrW0GQR1XS
SW954 M4LPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\NRW5XUUN3ME2wMlAyPzB3IN88US=> MWnTRW5ITVJ?
RL95-2 MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDnc4xKSzVyPUCuNFE4OzhizszN NY\wU3pMW0GQR1XS
LXF-289 NV:1PHdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDxTWM2OD1yLkCxO|ch|ryP MXXTRW5ITVJ?
OCUB-M NGLMS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX62cIp1UUN3ME2wMlAyQDJ4IN88US=> NYXLU41bW0GQR1XS
RKO MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7PTWM2OD1yLkCxPVg4KM7:TR?= NUDGbZNsW0GQR1XS
LOUCY MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjyTWM2OD1yLkCyNFUh|ryP MYHTRW5ITVJ?
NOS-1 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTzTWM2OD1yLkCyNFk{KM7:TR?= MVnTRW5ITVJ?
A4-Fuk Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3oWVhKSzVyPUCuNFIzOThizszN NGDIRlRUSU6JRWK=
A388 M{fvWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2H5N2lEPTB;MD6wNlIzPyEQvF2= MWTTRW5ITVJ?
TE-9 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX75fpcyUUN3ME2wMlAzOjZzIN88US=> NHn3R5ZUSU6JRWK=
KURAMOCHI M3frfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLYTWM2OD1yLkCyNlg2KM7:TR?= MWrTRW5ITVJ?
KALS-1 MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7UfZE4UUN3ME2wMlAzOzN6IN88US=> MYnTRW5ITVJ?
HOP-62 Ml34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET0NWZKSzVyPUCuNFI1OiEQvF2= Ml\RV2FPT0WU
RPMI-8402 MmfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\RTWM2OD1yLkCyOVA5KM7:TR?= NFvnRnJUSU6JRWK=
TE-1 NXLweVJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljlTWM2OD1yLkCyOVEzKM7:TR?= M2DleXNCVkeHUh?=
CCRF-CEM MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXETWM2OD1yLkCyOVQ{KM7:TR?= MnzDV2FPT0WU
HUTU-80 NFrxWHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[zOGlEPTB;MD6wNlYzPCEQvF2= M3;re3NCVkeHUh?=
NCI-H1648 MorYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HLbmlEPTB;MD6wNlY1PyEQvF2= Mnr0V2FPT0WU
HCE-4 MlnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq5TWM2OD1yLkCyOlgzKM7:TR?= NITiZmtUSU6JRWK=
ETK-1 M2r4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEK3N|Yh|ryP NUfKTFFUW0GQR1XS
TE-15 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33yXGlEPTB;MD6wNlc{QCEQvF2= MYTTRW5ITVJ?
BE-13 M4Lu[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\1cWlSUUN3ME2wMlAzPzRizszN NEDrbmlUSU6JRWK=
KE-37 M2HkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LxWGlEPTB;MD6wNlc1OSEQvF2= NYTYPIVWW0GQR1XS
NCI-H1355 MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;Hb25jUUN3ME2wMlAzPzh|IN88US=> MonwV2FPT0WU
TE-11 NWTJS3ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7zTWM2OD1yLkCyPFA6KM7:TR?= MkH6V2FPT0WU
BL-70 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEK4OVch|ryP NV7RUVFEW0GQR1XS
ES6 M{T6Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jibGlEPTB;MD6wNlg5OSEQvF2= MnXYV2FPT0WU
GT3TKB NFXnN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHhPJR3UUN3ME2wMlAzQTV|IN88US=> MnPpV2FPT0WU
LB647-SCLC MkDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvXTVZKSzVyPUCuNFMyQTVizszN MlHBV2FPT0WU
NB13 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHy5S4ZKSzVyPUCuNFM{OTZizszN NV3QVlhzW0GQR1XS
ST486 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33xeWlEPTB;MD6wN|M{PyEQvF2= Ml76V2FPT0WU
NCI-H82 M1vNZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELKXVZKSzVyPUCuNFM{PDNizszN M1zPW3NCVkeHUh?=
NTERA-S-cl-D1 NIf4c|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnDUHZHUUN3ME2wMlA{Ozl7IN88US=> NEe1UIZUSU6JRWK=
ES4 Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEO0OlMh|ryP NXn3SpNPW0GQR1XS
SK-NEP-1 M4Tp[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn3N2tKSzVyPUCuNFM1QTlizszN NIrUcG9USU6JRWK=
Becker NV\zNmNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrm[VV6UUN3ME2wMlA{PTV3IN88US=> M2PiSHNCVkeHUh?=
A101D NUG0[YJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vsV2lEPTB;MD6wN|c1QCEQvF2= M1K5RXNCVkeHUh?=
SK-UT-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu3XZR{UUN3ME2wMlA{Pzd2IN88US=> M2LCU3NCVkeHUh?=
SW982 M2Gwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEO3PUDPxE1? MmLDV2FPT0WU
TE-10 MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPvepZXUUN3ME2wMlA1ODR4IN88US=> NVPYWIJiW0GQR1XS
OVCAR-4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfoTWM2OD1yLkC0NFU6KM7:TR?= NEfDS49USU6JRWK=
KP-N-YS NICwOI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu1[mRKSzVyPUCuNFQxQDVizszN MYHTRW5ITVJ?
BL-41 NH7GZVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r6emlEPTB;MD6wOFEzPSEQvF2= NWTNSXVvW0GQR1XS
MZ1-PC NIXWSopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfQcndKSzVyPUCuNFQyOjdizszN MXTTRW5ITVJ?
PF-382 NYHTVHpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrnTWM2OD1yLkC0NVk5KM7:TR?= M{\lfnNCVkeHUh?=
MOLT-13 NHXkN2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjKdopZUUN3ME2wMlA1OjN6IN88US=> MWrTRW5ITVJ?
HCC1599 NYP3eYhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrob|lKSzVyPUCuNFQzPThizszN MX;TRW5ITVJ?
IST-MEL1 M1K2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMES0OFIh|ryP NFLaOpRUSU6JRWK=
LU-139 M17iTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfJOmJKSzVyPUCuNFQ1PDJizszN NEHmXINUSU6JRWK=
MS-1 NGSyU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jwfmlEPTB;MD6wOFcxOSEQvF2= NV\MfFZMW0GQR1XS
MFH-ino NF[5SmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEWwNFMh|ryP NIq0TFRUSU6JRWK=
IMR-5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;WTGJKSzVyPUCuNFUxOjFizszN NXi2[FA2W0GQR1XS
TE-5 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjqTWM2OD1yLkC1NFY{KM7:TR?= MlTEV2FPT0WU
DJM-1 NID6VnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDR[3JKSzVyPUCuNFUyPDJizszN MWDTRW5ITVJ?
NB17 NYPT[XZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;Gc3RwUUN3ME2wMlA2OjB5IN88US=> MYDTRW5ITVJ?
KARPAS-45 M1vWUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHOTWM2OD1yLkC1N|U5KM7:TR?= M1vFNnNCVkeHUh?=
TGBC1TKB NH;JS3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\H[WRKSzVyPUCuNFU1ODVizszN NH;He2tUSU6JRWK=
ML-2 MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LaPWlEPTB;MD6wOVQyPCEQvF2= NH3JZXBUSU6JRWK=
no-10 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnBU2FuUUN3ME2wMlA2PDd2IN88US=> NUnIV3AzW0GQR1XS
CTV-1 NYj2UVVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHjXIlyUUN3ME2wMlA2PTB{IN88US=> M2nZ[3NCVkeHUh?=
SJSA-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnLOYZKSzVyPUCuNFU2OiEQvF2= NEHo[YlUSU6JRWK=
HC-1 NHHqd3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvYTWM2OD1yLkC1OVk4KM7:TR?= NIfNfnRUSU6JRWK=
TE-12 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfCbnJKSzVyPUCuNFU3OTNizszN MXjTRW5ITVJ?
KY821 NXrpPWRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnhTWM2OD1yLkC1OlMzKM7:TR?= MXvTRW5ITVJ?
TALL-1 NUX0WJpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrjZmtKSzVyPUCuNFU4ODhizszN MYLTRW5ITVJ?
DEL NX7ycVJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fTPGlEPTB;MD6wOVcxQSEQvF2= M{TlU3NCVkeHUh?=
TE-6 M{HQSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXywUI4{UUN3ME2wMlA2PzJ{IN88US=> MmDxV2FPT0WU
SK-LMS-1 NUTqdlJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPKTWM2OD1yLkC1PFA2KM7:TR?= NGDqRZhUSU6JRWK=
EW-1 NFTmcJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;0TWM2OD1yLkC1PFM4KM7:TR?= M{XSdnNCVkeHUh?=
8-MG-BA M2DnXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInxbZZKSzVyPUCuNFU5PTFizszN MlrtV2FPT0WU
NALM-6 Ml\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEW5O|Mh|ryP MlrUV2FPT0WU
LB771-HNC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn6d5RpUUN3ME2wMlA2QTd7IN88US=> M2fkS3NCVkeHUh?=
HT-144 M2TmOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnuOJJTUUN3ME2wMlA3OTNizszN MnrqV2FPT0WU
KM-H2 NIjGTIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDwTWM2OD1yLkC2NlIyKM7:TR?= NIGweFNUSU6JRWK=
SF268 NEm5b3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwME[yPFYh|ryP MV\TRW5ITVJ?
RS4-11 M3jrUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PXZWlEPTB;MD6wOlMxPCEQvF2= MXjTRW5ITVJ?
MHH-PREB-1 NUHt[HJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj0TWM2OD1yLkC2N|E6KM7:TR?= MlnKV2FPT0WU
ATN-1 NV33XnRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fucmlEPTB;MD6wOlM1PSEQvF2= MUDTRW5ITVJ?
BB30-HNC NVrtfGhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnZbG1VUUN3ME2wMlA3PDN4IN88US=> M2PGeXNCVkeHUh?=
CPC-N MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S0TGlEPTB;MD6wOlUzPCEQvF2= M1jsd3NCVkeHUh?=
NB1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH6OIZKSzVyPUCuNFY3OTNizszN MVnTRW5ITVJ?
KS-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jabWlEPTB;MD6wOlc1QCEQvF2= NXn1Nmw5W0GQR1XS
RXF393 NVO0cVlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{naeWlEPTB;MD6wOlc3PCEQvF2= MmrhV2FPT0WU
IST-SL2 NUPsUmc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj4R3R5UUN3ME2wMlA4ODB2IN88US=> MlHaV2FPT0WU
GI-ME-N MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEeyPFYh|ryP MXfTRW5ITVJ?
VA-ES-BJ NHOweY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmeyTWM2OD1yLkC3OFc2KM7:TR?= NUXOZpNjW0GQR1XS
NCI-H1581 MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLZZlZKSzVyPUCuNFc1PzhizszN NHfLcpBUSU6JRWK=
U-266 NX3HW3dJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEe0PVch|ryP MWDTRW5ITVJ?
DMS-114 M2fLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW2TWM2OD1yLkC3OVI5KM7:TR?= NXzMXHpIW0GQR1XS
NCI-H187 Mn71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[4TWJKSzVyPUCuNFc4OjZizszN MlrwV2FPT0WU
SW962 M{XYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jtbGlEPTB;MD6wO|g{QSEQvF2= NYr6dYFSW0GQR1XS
MONO-MAC-6 NWjRTYI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\3TWM2OD1yLkC3PVg3KM7:TR?= NIPnfYpUSU6JRWK=
MOLT-16 NF:4d5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjJT45HUUN3ME2wMlA5OTJzIN88US=> NHLPZmtUSU6JRWK=
KNS-42 NVflR2w4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfjfWZqUUN3ME2wMlA5OTZzIN88US=> M4DoVnNCVkeHUh?=
CMK MmXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq3bIJPUUN3ME2wMlA5OjJ3IN88US=> NXG1ZlcyW0GQR1XS
Ramos-2G6-4C10 M{HqfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\YTnB2UUN3ME2wMlA5OjJ3IN88US=> NFTXOJpUSU6JRWK=
Daudi M1XlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPtb3FwUUN3ME2wMlA5OjV4IN88US=> MU\TRW5ITVJ?
NCI-H510A MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEizN|Yh|ryP NVrLSYV7W0GQR1XS
LB831-BLC NVjaNpFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljsTWM2OD1yLkC4OVYyKM7:TR?= M1:1WHNCVkeHUh?=
HEL M33nPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTCUYk2UUN3ME2wMlA5PjZ6IN88US=> NXr0NnNnW0GQR1XS
LU-134-A MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEi3NFgh|ryP NILIVG9USU6JRWK=
NCI-H1694 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm3TWM2OD1yLkC4O|Q1KM7:TR?= NYCwOpZGW0GQR1XS
KGN MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XRcWlEPTB;MD6wPFc2QSEQvF2= NGnMWnNUSU6JRWK=
A253 NGr2cFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3y2SWlEPTB;MD6wPFgzOiEQvF2= NGP4N5lUSU6JRWK=
DG-75 NID0dlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEi5NlIh|ryP NFHtS4ZUSU6JRWK=
MOLT-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE[5UGdKSzVyPUCuNFg6QDNizszN NXzlcmdOW0GQR1XS
NCI-SNU-5 MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPDW2dLUUN3ME2wMlA6OjV6IN88US=> NVnaSGpyW0GQR1XS
ONS-76 NH2wcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljBTWM2OD1yLkC5Nlc3KM7:TR?= M1XCUHNCVkeHUh?=
NCI-H446 NYfY[oIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMEm0OlIh|ryP NV32dYRJW0GQR1XS
COR-L279 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEm1OVYh|ryP Mly3V2FPT0WU
Calu-6 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEm1PVgh|ryP Ml7mV2FPT0WU
BC-3 M3P3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX74cnBZUUN3ME2wMlA6PjZ{IN88US=> MYLTRW5ITVJ?
NCI-H2126 M{nWWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;pem0zUUN3ME2wMlA6PzlzIN88US=> MX7TRW5ITVJ?
NCI-H1882 M1L6eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEm4NFkh|ryP NF33Ro1USU6JRWK=
BB65-RCC NYS5fmFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nPVmlEPTB;MD6xNFI6PCEQvF2= MVjTRW5ITVJ?
DU-4475 NXr4c4d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXricWhPUUN3ME2wMlExPDB5IN88US=> MXHTRW5ITVJ?
NCI-H526 NWCx[296T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXaTWM2OD1yLkGwOFQh|ryP NFPze4VUSU6JRWK=
NEC8 NF;h[VVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfETWM2OD1yLkGwOVI2KM7:TR?= NWey[Yl6W0GQR1XS
NCI-H1304 Ml2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC5TWM2OD1yLkGwOVk1KM7:TR?= MXzTRW5ITVJ?
L-540 NX\wWGRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTDPIFuUUN3ME2wMlExPzB6IN88US=> MnG5V2FPT0WU
NCI-SNU-16 NX3OS21ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrpbpNMUUN3ME2wMlExPzR{IN88US=> NY\sO2dZW0GQR1XS
HD-MY-Z M4G2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDyfYxKSzVyPUCuNVA5PTZizszN MmfFV2FPT0WU
K-562 NVzFT3Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXSRpFKSzVyPUCuNVA5PThizszN MYnTRW5ITVJ?
JAR NUjneWV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMUC5NlUh|ryP NUG2dnBWW0GQR1XS
MZ2-MEL NW\3TG4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\STWM2OD1yLkGxNFUh|ryP Mn7KV2FPT0WU
L-363 NUjmVWFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMUGwO|kh|ryP MmLwV2FPT0WU
BV-173 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrhbIFSUUN3ME2wMlEyOjR|IN88US=> NHu3TYdUSU6JRWK=
NCI-H524 NXPuVodCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMUGyO|Qh|ryP NFH1VYxUSU6JRWK=
EoL-1-cell M3rKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3LWJVzUUN3ME2wMlEyPjd{IN88US=> NIfPZnZUSU6JRWK=
K052 NVvkXlR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP6TWM2OD1yLkGxO|EzKM7:TR?= NHX4eFBUSU6JRWK=
TK10 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDNTWM2OD1yLkGxO|I5KM7:TR?= NF74e|dUSU6JRWK=
KU812 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDXTJZKSzVyPUCuNVIxPDRizszN NXrLO5h1W0GQR1XS
RPMI-8226 M1HGW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMUKwOVIh|ryP M13CSXNCVkeHUh?=
MZ7-mel NVLZ[4o4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\LbpBKSzVyPUCuNVIzOzdizszN M{jXOHNCVkeHUh?=
SK-PN-DW MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHIcoVpUUN3ME2wMlEzOjh5IN88US=> MnPUV2FPT0WU
SR MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\NPIpKSzVyPUCuNVI1PDFizszN M2r2[3NCVkeHUh?=
RPMI-6666 NIW1OJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvRUWZKSzVyPUCuNVI4PDNizszN MmnrV2FPT0WU
no-11 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPZTWM2OD1yLkGyPFY6KM7:TR?= NWnCZ|BzW0GQR1XS
EW-3 NH\Y[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMUK4PVMh|ryP NVHhPHJkW0GQR1XS
LAMA-84 M13vUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnYTWM2OD1yLkGzNVg4KM7:TR?= NXHUfJVOW0GQR1XS
HT MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDaXotKSzVyPUCuNVM2PzRizszN NUDSd3hDW0GQR1XS
KP-N-RT-BM-1 M3v2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TZcWlEPTB;MD6xN|YyOiEQvF2= M175bXNCVkeHUh?=
NCI-H747 NH;FVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHFTWM2OD1yLkGzO{DPxE1? M3:4[3NCVkeHUh?=
NCCIT NGTufoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXDTWM2OD1yLkGzPVM6KM7:TR?= MX3TRW5ITVJ?
MLMA NUXEc45UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmwTWM2OD1yLkG0NVY4KM7:TR?= M4KyZXNCVkeHUh?=
LP-1 MoXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTmTXlIUUN3ME2wMlE1OjRizszN MWHTRW5ITVJ?
CAL-148 NWDHd3RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrJdZVsUUN3ME2wMlE1PDh|IN88US=> M2LIXXNCVkeHUh?=
GB-1 M4HVV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMUS1NlYh|ryP NUXYUIQyW0GQR1XS
COR-L88 M3\1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMUS4NFIh|ryP MoDTV2FPT0WU
NKM-1 M3iyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLScY5KSzVyPUCuNVQ6ODZizszN NF3U[5lUSU6JRWK=
NB5 M{XFTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrITWM2OD1yLkG1OFYzKM7:TR?= Ml;CV2FPT0WU
SH-4 NUXpfGJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjyXmlKSzVyPUCuNVU1PjZizszN MY\TRW5ITVJ?
EM-2 NFPoXGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDSdWJmUUN3ME2wMlE2PDZ5IN88US=> NIjGRVdUSU6JRWK=
TGBC24TKB MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LDRmlEPTB;MD6xOVY2QSEQvF2= NU[yWFhRW0GQR1XS
SCLC-21H NGSxRldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjEeIhOUUN3ME2wMlE2PzB{IN88US=> NITmNXJUSU6JRWK=
COLO-684 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInuUGxKSzVyPUCuNVU4OjFizszN MmLkV2FPT0WU
KINGS-1 NGXYdoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS1[pVJUUN3ME2wMlE2QTFizszN NYfqTXVZW0GQR1XS
LS-123 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMUW5NVch|ryP MXnTRW5ITVJ?
MC116 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrSd2tqUUN3ME2wMlE3OTV6IN88US=> MU\TRW5ITVJ?
SU-DHL-1 MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\UVpd[UUN3ME2wMlE3OjB4IN88US=> MYDTRW5ITVJ?
NCI-H64 MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMU[zOFch|ryP NVHrfmlvW0GQR1XS
HCE-T M3HSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\iVI9KSzVyPUCuNVY2ODRizszN MlP0V2FPT0WU
LOXIMVI M4\Lc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe5doFKSzVyPUCuNVY6PDlizszN NX7NNI57W0GQR1XS
ARH-77 NH;mUlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;K[oNKSzVyPUCuNVc{PzlizszN MYfTRW5ITVJ?
DOHH-2 M{jOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXV[5hWUUN3ME2wMlE4Pjd{IN88US=> NH3FZo5USU6JRWK=
COLO-320-HSR M2nSWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M134UGlEPTB;MD6xPFE2PCEQvF2= M{TXSHNCVkeHUh?=
NB6 NXroWY1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\xZnZKSzVyPUCuNVg2PjZizszN MlvGV2FPT0WU
L-428 M4nNV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\lUGlEPTB;MD6xPFgyOyEQvF2= M1PxTHNCVkeHUh?=
SNB75 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLiTWM2OD1yLkG4PFI1KM7:TR?= NV\veVRDW0GQR1XS
NCI-H2141 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMUmwNVEh|ryP MlrnV2FPT0WU
KARPAS-299 M2fPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\0TWM2OD1yLkG5NlQyKM7:TR?= Mk\YV2FPT0WU
LC4-1 M3\OPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoGxTWM2OD1yLkG5OVAzKM7:TR?= NFeweYxUSU6JRWK=
UACC-257 M1zGbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ZTWM2OD1yLkG5PVQ4KM7:TR?= MlHMV2FPT0WU
EVSA-T MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fpUmlEPTB;MD6yNFMyOiEQvF2= M{XOOXNCVkeHUh?=
JiyoyeP-2003 NFHtdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH0R|NKSzVyPUCuNlA1PzdizszN MVLTRW5ITVJ?
NCI-H720 MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLrTWM2OD1yLkKwOVI2KM7:TR?= MWPTRW5ITVJ?
GAK NWqwNIM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPWfFR[UUN3ME2wMlIyOTh7IN88US=> NV;K[pZrW0GQR1XS
HH MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofOTWM2OD1yLkKxOFA2KM7:TR?= M3\F[XNCVkeHUh?=
NCI-H1436 MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\STWM2OD1yLkKxOFY1KM7:TR?= M1jkS3NCVkeHUh?=
GR-ST NHS0[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:4NFNKSzVyPUCuNlE1QDhizszN NGnJdJNUSU6JRWK=
BC-1 NILpTFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfQcJNpUUN3ME2wMlIzPjF4IN88US=> MkXCV2FPT0WU
SIG-M5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnjbGRWUUN3ME2wMlIzPzJ5IN88US=> NGnnbnZUSU6JRWK=
NCI-H345 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPhdItoUUN3ME2wMlI{QDB3IN88US=> NE\OfodUSU6JRWK=
OPM-2 NX;NcWtyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\1TWM2OD1yLkKzPFgzKM7:TR?= NYq0PVduW0GQR1XS
LB1047-RCC NWTDW3VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTXcmtKSzVyPUCuNlQ1OSEQvF2= NHnCNmJUSU6JRWK=
CTB-1 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrFbHBXUUN3ME2wMlI1PDl|IN88US=> MVjTRW5ITVJ?
A3-KAW MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ryXGlEPTB;MD6yOVM1OSEQvF2= Mnz0V2FPT0WU
SF126 NFLGPIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{m0U2lEPTB;MD6yOVM5OyEQvF2= M2XSdXNCVkeHUh?=
KARPAS-422 NIHtdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf4TWM2OD1yLkK1OFM2KM7:TR?= MkntV2FPT0WU
MEG-01 NH\seWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjETWM2OD1yLkK1Olc{KM7:TR?= MnTSV2FPT0WU
NCI-H209 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nqXWlEPTB;MD6yOlM4PCEQvF2= NFL5OnVUSU6JRWK=
SBC-1 MkTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMk[1JO69VQ>? MYDTRW5ITVJ?
K5 NVzOXpZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHsVo5KSzVyPUCuNlY6QDRizszN NXHEfVU{W0GQR1XS
QIMR-WIL M33INGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PE[GlEPTB;MD6yO|E2PSEQvF2= NVj6e5dJW0GQR1XS
NMC-G1 MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X6WmlEPTB;MD6yPFIyPyEQvF2= M17JfXNCVkeHUh?=
IST-MES1 NUXUeZNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\iSGdKSzVyPUCuNlkzOzhizszN M3P0WHNCVkeHUh?=
SW684 NX;tUXZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TtXmlEPTB;MD6zNFA1PyEQvF2= NEDOUIRUSU6JRWK=
MV-4-11 NEjjbZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DTRWlEPTB;MD6zNFc5QCEQvF2= M{DLc3NCVkeHUh?=
LAN-6 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7zTWM2OD1yLkOxOVczKM7:TR?= NIrCWI5USU6JRWK=
RH-1 NHHJeYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrPTWM2OD1yLkOxPFcyKM7:TR?= MoThV2FPT0WU
CP66-MEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XZOGlEPTB;MD6zNVg4QCEQvF2= NYjiU4dPW0GQR1XS
EC-GI-10 NXnXPXFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj1OYxMUUN3ME2wMlMzQTh5IN88US=> M17oenNCVkeHUh?=
GDM-1 M4ftTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33ibWlEPTB;MD6zN|A2QSEQvF2= NFXBVG9USU6JRWK=
IST-SL1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorYTWM2OD1yLkO0PVE1KM7:TR?= NFTOT5NUSU6JRWK=
KMOE-2 M3npcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;NOoZKSzVyPUCuN|UyPzVizszN NIDl[lFUSU6JRWK=
OS-RC-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwM{W1OFQh|ryP MXnTRW5ITVJ?
HDLM-2 MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwM{e4NVQh|ryP MkXTV2FPT0WU
DSH1 NYDZfIJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwM{i2N|Eh|ryP MXXTRW5ITVJ?
LS-1034 NUm0R2ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwM{i5OVQh|ryP MkDlV2FPT0WU
LB373-MEL-D MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXntVJhiUUN3ME2wMlM6OTl5IN88US=> NFqyO3JUSU6JRWK=
GOTO NH;kVGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;OTWM2OD1yLkSyNVE5KM7:TR?= NV;zT3lyW0GQR1XS
MRK-nu-1 M{jGVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwNEKyNFUh|ryP NFz5blJUSU6JRWK=
SK-MM-2 NVz0Wo5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPne|JCUUN3ME2wMlQ{PDR{IN88US=> M3;udHNCVkeHUh?=
BOKU MkPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDETWM2OD1yLkSzO|kzKM7:TR?= MkGxV2FPT0WU
NOMO-1 NWW5WodrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXSXYlQUUN3ME2wMlQ{QDZizszN NUTrVYR{W0GQR1XS
J-RT3-T3-5 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPJTWM2OD1yLkS0PFc5KM7:TR?= NWXWPXB1W0GQR1XS
COLO-668 NFG5eopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwNEW2Olgh|ryP MkLUV2FPT0WU
SF539 NV7o[4RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHNR49KSzVyPUCuOFg3QDRizszN MkTiV2FPT0WU
LB2518-MEL NVTiNYNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4C5RmlEPTB;MD60PVcxOyEQvF2= NXPtVGNXW0GQR1XS
TE-441-T NUjUc|VFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrzbHRMUUN3ME2wMlUxOTJizszN MYrTRW5ITVJ?
MDA-MB-134-VI NIXY[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\rVGFKSzVyPUCuOVA6OjFizszN NVXnepJuW0GQR1XS
SCC-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK3NnV2UUN3ME2wMlUyQDd|IN88US=> M1LSVHNCVkeHUh?=
KLE Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwNUKxO|Eh|ryP NY\qOWppW0GQR1XS
LB2241-RCC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInKRW1KSzVyPUCuOVI2OjVizszN NX7ET3VMW0GQR1XS
NCI-H1417 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwNUO0N|Uh|ryP MWfTRW5ITVJ?
NCI-H2081 M{\qNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jYd2lEPTB;MD61PFYyOSEQvF2= MWDTRW5ITVJ?
NCI-H1522 NF3BOXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPVd4tKSzVyPUCuOVk{QDNizszN MX;TRW5ITVJ?
NCI-H889 NH\uU4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor0TWM2OD1yLkW5PFQ1KM7:TR?= MUTTRW5ITVJ?
CGTH-W-1 M3fOU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrIVFBKSzVyPUCuOlA4PTVizszN MmDMV2FPT0WU
EB-3 NYnv[5M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmCyTWM2OD1yLk[xNVU{KM7:TR?= NX7Fd4hrW0GQR1XS
D-336MG Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{WxfGlEPTB;MD62NVc6OSEQvF2= NGDkWYhUSU6JRWK=
LC-1F NH;RU2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPlS2dYUUN3ME2wMlYzPTl{IN88US=> NI\jUplUSU6JRWK=
MHH-NB-11 M2XHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M362c2lEPTB;MD62N|gxOSEQvF2= MWjTRW5ITVJ?
SK-N-FI NEj0fFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jyRWlEPTB;MD62N|kyKM7:TR?= MmDQV2FPT0WU
NCI-H69 NXX1SXVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rhSWlEPTB;MD62OFg4QSEQvF2= MXvTRW5ITVJ?
SCH NIfxeY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP3TWM2OD1yLk[2NFI{KM7:TR?= Mm\RV2FPT0WU
LS-513 M4TrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X3XGlEPTB;MD62O|I2QSEQvF2= NUfWV2QzW0GQR1XS
CP67-MEL M2qwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\CfmtKSzVyPUCuOlc2QTZizszN NH3FVFFUSU6JRWK=
GCIY MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zON2lEPTB;MD63NFM3OyEQvF2= NXLTZWVwW0GQR1XS
SHP-77 NWjnTY1tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[4XGlEPTB;MD63NFc{PCEQvF2= NWLIb5Q4W0GQR1XS
EHEB NIfSOZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jIUWlEPTB;MD63NVg2PCEQvF2= MlfSV2FPT0WU
D-247MG NVS2c|VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvXZYxKSzVyPUCuO|MzOzJizszN NEPBNnhUSU6JRWK=
Raji M3PtVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLETWM2OD1yLke0PVg6KM7:TR?= M{nVfXNCVkeHUh?=
MPP-89 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTjTWM2OD1yLke1PVc5KM7:TR?= NXniXYdDW0GQR1XS
EKVX M2jCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXrcmw2UUN3ME2wMlc6ODd|IN88US=> MnO1V2FPT0WU
HCC2218 NWe5e3l7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwN{mxN|Eh|ryP MoXkV2FPT0WU
KNS-81-FD Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;KfnFKSzVyPUCuPFExOTFizszN MnrEV2FPT0WU
HCC2157 M3XKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\OTWM2OD1yLki0PVUyKM7:TR?= NHTa[W1USU6JRWK=
BT-474 M2jhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DGNmlEPTB;MD64PFg2PCEQvF2= M2m3d3NCVkeHUh?=
NCI-H748 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1G0NmlEPTB;MD65NVIh|ryP M4fUenNCVkeHUh?=
EW-24 M1TFVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfUPJpKSzVyPUCuPVIxODJizszN NUXVO2hWW0GQR1XS
D-263MG NYe3T4FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rvVmlEPTB;MD65OFUyOiEQvF2= NGSzRWRUSU6JRWK=
OMC-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXDN2NKSzVyPUCuPVY{PzNizszN MVLTRW5ITVJ?
NCI-H2196 M3P0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnLT2wzUUN3ME2wMlk4Pzd5IN88US=> MWjTRW5ITVJ?
HAL-01 MlnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXN[5U1UUN3ME2wMlk6QDd{IN88US=> MlvjV2FPT0WU
NCI-H2107 M3vDXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjQZWZKSzVyPUGuNFE5PTRizszN M1nBfHNCVkeHUh?=
LB996-RCC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\iSXdpUUN3ME2xMlA5ODVzIN88US=> MUDTRW5ITVJ?
NCI-H1395 NGG1dWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPtTWM2OD1zLkGwOlch|ryP NGn4Zo5USU6JRWK=
CHP-126 MkHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwMU[xPVkh|ryP MYjTRW5ITVJ?
NB69 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S1[WlEPTB;MT6yOlE1QCEQvF2= M1S4VnNCVkeHUh?=
CAS-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFwM{SyN|Eh|ryP NWL0NZR1W0GQR1XS
JVM-3 NEm0VIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj0[XU{UUN3ME2xMlQ4QDV3IN88US=> NGq0UZdUSU6JRWK=
DMS-153 M2LMU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jOPGlEPTB;MT61O|Y4PCEQvF2= NGG2bGtUSU6JRWK=
SK-MEL-2 M{\GZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TBUGlEPTB;MT63NVc5QSEQvF2= MnzFV2FPT0WU
NCI-H1155 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nZOmlEPTB;MT63N|Y4PiEQvF2= NGrJZYxUSU6JRWK=
NCI-H1092 NWTMNYlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTFwN{[xPFIh|ryP MYDTRW5ITVJ?
LU-165 NFjPVGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnwWXJoUUN3ME2xMlg3PDd4IN88US=> M{ixSHNCVkeHUh?=
HL-60 M4TDVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TwTGlEPTB;MT65PVkxQCEQvF2= NHnQO4ZUSU6JRWK=
REH MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXVOmxiUUN3ME2yMlAxPTh{IN88US=> MWHTRW5ITVJ?
JVM-2 NVnaZ485T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP5b5p2UUN3ME2yMlA3OTN3IN88US=> NHTkeYNUSU6JRWK=
MN-60 NXHNbFFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\TTWM2OD1{LkG3N|A5KM7:TR?= M1PISnNCVkeHUh?=
SCC-15 NEPqeJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvCfZFDUUN3ME2yMlIxOjdizszN NFmweWpUSU6JRWK=
SNU-C1 NH;a[o9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW0cphKSzVyPUKuNlE{PDNizszN M3f0e3NCVkeHUh?=
SK-MEL-1 NWTYRpE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzLdW1KSzVyPUKuN|IxPDdizszN MknJV2FPT0WU
TGW NYexZoRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjnV|ZKSzVyPUKuN|UxOjdizszN MkLNV2FPT0WU
CA46 NGnWdIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJwN{W5Olch|ryP NX\y[3NZW0GQR1XS
NCI-H23 M3G4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;YT|ZKSzVyPUKuPFA4QTFizszN M4PjVHNCVkeHUh?=
MMAC-SF NXOzZ4tvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPNdWxKSzVyPUKuPFY3OjhizszN NG\mTXNUSU6JRWK=
NCI-H2171 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy4b4xRUUN3ME2zMlA{PDR6IN88US=> MoTqV2FPT0WU
A704 NYTtW|lOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG0b4xKSzVyPUOuNVQyQTRizszN MlO4V2FPT0WU
DB NXzhSYpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjBXnFnUUN3ME2zMlI2PTd4IN88US=> NFjD[IFUSU6JRWK=
NCI-H719 NWHGcGY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;iZXFKSzVyPUOuN|A{QDRizszN Mo\PV2FPT0WU
MC-CAR M2rR[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M163cGlEPTB;Mz61OFgyPyEQvF2= MYLTRW5ITVJ?
SIMA M2j2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\EXVJUUUN3ME2zMlU5PDF4IN88US=> NH3MTmJUSU6JRWK=
SW872 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LQPWlEPTB;Mz63PFExOSEQvF2= MV7TRW5ITVJ?
HCC1187 MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jS[WlEPTB;Mz63PFMyPSEQvF2= NWKybnNHW0GQR1XS
EW-13 MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPzTWM2OD1|LkizOFE4KM7:TR?= M37KUnNCVkeHUh?=
NCI-SNU-1 NVm3ZpdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjFTWM2OD12LkKxPVk6KM7:TR?= NInoW2NUSU6JRWK=
NCI-H226 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj1TWM2OD12LkOzOlA3KM7:TR?= Mn3IV2FPT0WU
RPMI-8866 MmXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn2c2VKSzVyPUSuN|YxOjlizszN NUHaUIhxW0GQR1XS
OCI-AML2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HLR2lEPTB;ND61OVI{KM7:TR?= Mly2V2FPT0WU
LU-65 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\mVmVKSzVyPUSuPVMxOzNizszN Ml:yV2FPT0WU
SK-N-DZ NHrYXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTVwNkO0OlUh|ryP NWnTb2pmW0GQR1XS
NB14 NFW0[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzpbIZKSzVyPUWuPVcyOzVizszN MmHlV2FPT0WU
COLO-829 M3rVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrYTWM2OD14LkOzN|U6KM7:TR?= MUPTRW5ITVJ?
MHH-CALL-2 NIGxZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjBc21mUUN3ME22MlUyPTB6IN88US=> M3jMWXNCVkeHUh?=
NCI-H1770 NGC1WZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPUSYpuUUN3ME22MlY3QTB2IN88US=> NXfXN2g3W0GQR1XS
ECC4 NYL0W5J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[0cYN4UUN3ME22MlgzOTd7IN88US=> NHOzUXBUSU6JRWK=
A498 NECz[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDzTWM2OD14Lki3NVkzKM7:TR?= M1exVXNCVkeHUh?=
DMS-79 M2j1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmwXlA6UUN3ME23MlA1PTF{IN88US=> MmfEV2FPT0WU
P30-OHK NW\hc5FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfMTWM2OD15LkKxPVA3KM7:TR?= MV;TRW5ITVJ?
D-502MG NFuyNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;ZeldKSzVyPUeuPVg{PiEQvF2= MWnTRW5ITVJ?
RCC10RGB NWGyXJlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f1U2lEPTB;OD6wOlI5KM7:TR?= MlHkV2FPT0WU
U-698-M M{jvPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nEOWlEPTB;OD6yPVIzPiEQvF2= NGjrblBUSU6JRWK=
BB49-HNC M4TkfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO5SmhKSzVyPUmuOFIzPjVizszN NYjjbFhFW0GQR1XS
ES1 NXXhW5J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX6w[VR1UUN3ME25MlY5QTV4IN88US=> M37mNXNCVkeHUh?=
MFM-223 M3HFPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofqTWM2OD1zMD65PVI4KM7:TR?= Mo\FV2FPT0WU
C2BBe1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHQfHRKSzVyPUGxMlM2OjNizszN MYHTRW5ITVJ?
EB2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTHR5RYUUN3ME2xNk43QDhzIN88US=> NEfFTJpUSU6JRWK=
C8166 NWPaNFRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF|LkizNFMh|ryP M1LSSnNCVkeHUh?=
ES3 NFzhTW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPaTWM2OD1zMz65PVc4KM7:TR?= MVnTRW5ITVJ?
NCI-H1650 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7iTWM2OD1zNj6zO|Y2KM7:TR?= M4T3NXNCVkeHUh?=
Mo-T NGe0eFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rCb2lEPTB;MUeuOFAzQSEQvF2= MUTTRW5ITVJ?
NB7 M4HlOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF5Lke0Olch|ryP M1S3TnNCVkeHUh?=
ES7 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTF7LkW1NFch|ryP MmjaV2FPT0WU
ES5 M2Wye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJzLke2O|Eh|ryP NFTKfJdUSU6JRWK=
MSTO-211H M4jRS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmroTWM2OD1{MT64PFU5KM7:TR?= MnvvV2FPT0WU
U-87-MG NGTLSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XlU2lEPTB;MkWuNVk3PiEQvF2= MlfJV2FPT0WU
THP-1 M4HKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnQXo1KSzVyPUK5MlczODFizszN MnvRV2FPT0WU
NB10 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\VWm1HUUN3ME2zNE4zPjl2IN88US=> NIPTXIRUSU6JRWK=
NH-12 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTN|LkKwNVch|ryP M2fRNXNCVkeHUh?=
COLO-824 NGfxS2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LWTmlEPTB;M{SuNVAxPiEQvF2= NEHNVJZUSU6JRWK=
SKM-1 NIq2fmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILBOJhKSzVyPUO3Mlg1OjJizszN M4jHeXNCVkeHUh?=
NCI-H1838 NV;LToh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTFTWM2OD1|OD6zO|k4KM7:TR?= MWrTRW5ITVJ?
RL NWLKb2t2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3Nem5IUUN3ME2zPU4zPDd5IN88US=> M2XMdXNCVkeHUh?=
COLO-800 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTRTWM2OD12MD6wO|c{KM7:TR?= MUHTRW5ITVJ?
KG-1 M1i3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;0RmlEPTB;NECuPFk2PSEQvF2= NW[xPZJjW0GQR1XS
TUR MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj4PGpKSzVyPUSxMlY{QTlizszN MYHTRW5ITVJ?
LNCaP-Clone-FGC MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUmxXWRRUUN3ME20NU46ODF5IN88US=> NUPXeY1HW0GQR1XS
NCI-H322M MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S2T2lEPTB;NEKuOVk5PCEQvF2= NXK3UGI3W0GQR1XS
LNCaP  MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP1TWM2OD17MT6zJI5O MUWyOVUxPTF5NB?=
C4-2 MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfGfXdiUUN3ME24JI5O M17mSlI2PTB3MUe0
JURKAT NVjzSpJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[yOEBp NGe3VZpKSzVyPUSxOk43PiCwTR?= NFjpc2kzPDVzOUm5OS=>
MOLT-4 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPsVWZzOjRiaB?= MoHtTWM2OD1{OEWzMlUhdk1? NXXCRmVHOjR3MUm5PVU>
REH MoXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHThV4UzPCCq NXrnXFM{UUN3ME2yPFcvPjhibl2= M3TieVI1PTF7OUm1
NALM-6 MmrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV2yOEBp MUfJR|UxRTN2M{OwJI5O NYTPV5RDOjR3MUm5PVU>
RS 4;11 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrhR2IzPCCq NX7yemxDUUN3ME21NVkvODVibl2= NUPhe5RIOjR3MUm5PVU>
697 MmPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PFNVI1KGh? MWrJR|UxRTJzMEeuNUBvVQ>? NVrqcohFOjR3MUm5PVU>
SIL-ALL MkHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DTXFI1KGh? NWfGcIdpUUN3ME2xPVkvPzdibl2= NG\Ne2QzPDVzOUm5OS=>
CEM MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rqOlI1KGh? NETmbWdKSzVyPUWyMlE5KG6P MoDDNlQ2OTl7OUW=
P12 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrDcVMzPCCq M2D4N2lEPTB;M{muNlchdk1? M2fsT|I1PTF7OUm1
NALM-16 M1PYZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi2NlQhcA>? MmnJTWM2OD17Nj6yPEBvVQ>? NF7wO|czPDVzOUm5OS=>
JURKAT M4LlXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWG0PEBp NH\6dWlKSzVyPUG0Mlg1KG6P NHnsO|czPDVzOUm5OS=>
MOLT-4 NIrTPXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVq0PEBp M1r0VGlEPTB;Mk[uOkBvVQ>? M3TTTFI1PTF7OUm1
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NALM-6 NYPVSmpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HFflQ5KGh? MYTJR|UxRTJ|LkK2JI5O MY[yOFUyQTl7NR?=
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SIL-ALL NX;lbY0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLjOFghcA>? M3P4V2lEPTB;N{SuOlIhdk1? Mn;WNlQ2OTl7OUW=
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NALM-6 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDqNlA4OiCq MUTJR|UxRTFwN{igcm0> M16wfVI1PTF7OUm1
RS 4;11 MnL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUO3NkBp M3;kVGlEPTB;ND6zPEBvVQ>? MXiyOFUyQTl7NR?=
697 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzJO|IhcA>? MkfvTWM2OD15ND6yPEBvVQ>? MnjuNlQ2OTl7OUW=
SIL-ALL M4nQTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnQU4ljPzJiaB?= NVnxT|hTUUN3ME23MlIhdk1? MnyzNlQ2OTl7OUW=
CEM M3z6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW4VIh7PzJiaB?= MnjjTWM2OD13LkSyJI5O MY[yOFUyQTl7NR?=
P12 NEPzfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXWeYh2PzJiaB?= M3vXVWlEPTB;Nj6zO{BvVQ>? NX;SWlBEOjR3MUm5PVU>
NALM-16 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLIO|IhcA>? MnHXTWM2OD15Nz63N{BvVQ>? M1L1OFI1PTF7OUm1
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WER-Rb-1 NGf0SodCeG:ydH;zbZMhSXO|YYm= MVexMVUxKG6P MW[xNk8zPCCq M{n3[WROW09? NFzxbW9qdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ> M1XyWVI1OzZ4Nk[1
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G166 Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2KwVmlEPTB;Nz6wJI5O NHzLdGEzPDJyNEezNy=>
CB660 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTZwNDDuUS=> NXz1UoJFOjR{MES3N|M>
CB1117 NFPNU3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn3TWM2OD1zNT62JI5O M4\0RVI1OjB2N{Oz
KB-3-1 NEO2Z2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjz[W1[UUN3ME2xMlQ5KMLzIECuOVMhdk1? M3jsOVI{QTZ{NES1
KB-8-5-11 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTVwMEGgxtEhOi5yMTDuUS=> MXGyN|k3OjR2NR?=
KB-C-1 M{LKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnWTWM2OD1zNj63OkDDuSB2LkWxJI5O MoHCNlM6PjJ2NEW=
KB-V-1 NH3ITllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjVNm1KSzVyPUK4NU4zPCEEsTCzNU42PyCwTR?= M3TQXFI{QTZ{NES1
OVCAR-8 NIPtZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4f0SWlEPTB;Nz6xPUDDuSB|Lk[wJI5O NUnxd3pSOjN7NkK0OFU>
NCI-ADR-RES MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXhVoJQUUN3ME2xNlc{NjNyINMxJFE6OS5{MDDuUS=> NVP5Z3VFOjN7NkK0OFU>
MCF7 M4LUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn30TWM2OD13LkGxJOKyKDFwNEegcm0> M2Lv[lI{QTZ{NES1
MCF7-FLV1000 NFnyVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTN7Mz6xPEDDuSB5ND64N{BvVQ>? Ml;SNlM6PjJ2NEW=
S1 NGS5NWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJ2LkOwJOKyKDRwN{Wgcm0> MWmyN|k3OjR2NR?=
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CORL-23/P M13Femdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmzO4lKSzVyPUSuN|ghyrFiMT6yOUBvVQ>? MkHyNlM6PjJ2NEW=
CORL-23/R NU[0SFFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PUdGlEPTB;NT6xOkDDuSBzLkizJI5O MVGyN|k3OjR2NR?=
NIH3T3 M2PifWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO5VmNKSzVyPUSwMlYxKMLzIESuPVchdk1? NVvWb|ZsOjN7NkK0OFU>
NIH3T3-G185 M4jMVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn6cIdpUUN3ME2yOFE{NjRyINMxJFQzOy54NjDuUS=> M1;mVlI{QTZ{NES1
pcDNA-HEK293 NILlO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO4b3F7UUN3ME2yMlc2KMLzIECuOlchdk1? MVmyN|k3OjR2NR?=
MDR19-HEK293 M{PTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTh3LkWwJOKyKDF|Lk[3JI5O M1KxUFI{QTZ{NES1
R482-HEK293 M2PPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DyOmlEPTB;MkWuPVchyrFiND65OUBvVQ>? M3TKV|I{QTZ{NES1
MRP1-HEK293 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwOUmgxtEhOS52OTDuUS=> MnjGNlM6PjJ2NEW=
SF188 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVyzd3FGOTBvMUCwJI5O NI\INY8zPC17NjDo NULCTWNQTE2VTx?= MYXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWVvIHHu[EBkd26lZX70doF1cW:wLTDk[ZBm\GWwdDDtZY5v\XJ? MYWyN|g5PzZ2NR?=
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DU145 NIHNWoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzvWFRFVVOR NH\nbVlKSzVy4pk8OlAhdk1? MXqyN|g5PDR{OB?=
LNCaP  MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;CZXNFVVOR MojjTWM2OOLKvEe1JI5O MYWyN|g5PDR{OB?=
PC3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzEcG16TE2VTx?= MkjLTWM2OOLKvEG3OUBvVQ>? MXqyN|g5PDR{OB?=
RT4 NIewcIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\MTmlEPTB;MkeuNlEhdk1? NXPoVHB7OjN5OUK2N|k>
5637 NFm3RWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jHXGlEPTB;NEWuOFchdk1? MWeyN|c6OjZ|OR?=
T24 NF20dGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTd7LkGyJI5O NIi5bnYzOzd7Mk[zPS=>
MCF7  NEHhRZpHfW6ldHnvckBCe3OjeR?= NWDMOWRNOTByIH7N NHPzfmEyKGh? MYnEUXNQ NUHnXHhEemWmdXPld{B1cGViaX7keYN1cW:wIH;mxsBIemWkMT|CpHNoczFuwrDQd|ItyqCVZYLwbY5iOyxiYX7kxsBYcXOyMh?= NI\w[nczOzd5MEK0OC=>
KB-V1  MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTTTWM2OD1|LkmyJO69VQ>? M3;CS|I{PTl|MUm2
Hec50co NEn5[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDB[IlKSzVyPUWgcm0> M2jNcVI{OTR4Nki3
MDA-MB-468 NGXVSY5CeG:ydH;zbZMhSXO|YYm= MlzxNU82NzFyIH7N NYPCcGwxOjRxNEivO|IhcA>? MnfxSG1UVw>? MW\pcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NGXyOW0zOzF2NEK5OC=>
MCF10A MoXMRZBweHSxc3nzJGF{e2G7 MWKxM|UwOTBibl2= Mmi0NlQwPDhxN{KgbC=> NELEO3pFVVOR MlzTbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MnzINlMyPDR{OUS=
Huh-7 NYTjXXk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L4SVEwOTBxMUCwM|ExODBibl2= NE\EXGo1QCCq NHLUbXZl\WO{ZXHz[ZMhfGinIHPlcIwhfmmjYnnsbZR6KGSxc3Wt[IVx\W6mZX70cJk> MXGyNlc1PTV6Nx?=
Daoy  M1vDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;XSFEvQDd3LUK0NEBvVQ>? NXyzSVlmPzJiaB?= M{DjSGROW09? MlPUTWM2OD13IH7N NGnJWnozOjN7MEK3PS=>
ONS-76 M1\ZPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjiSJAyNjh5NT2yOFAhdk1? MoPtO|IhcA>? MnjUSG1UVw>? MVLJR|UxRTdwNTDuUS=> NX3XeZVTOjJ|OUCyO|k>
SUM 149 M{\KNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXieGoxNTFyMDDuUS=> M17DUFczKGh? M3mzRolvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> MnnINlI{ODl7M{m=
MDA-MB-231 NGHmeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfaNE0yODBibl2= NFH3N5E4OiCq M1Xl[olvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> MXGyNlMxQTl|OR?=
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BT-474-M1 Mn7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDrcnQxNTFyMDDuUS=> NUjhUFFbPzJiaB?= NF6zcItqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> NH;yR2ozOjNyOUmzPS=>
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T47D MkewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfPNIQxNTFyMDDuUS=> NYXJVmZpPzJiaB?= NYHT[YJLcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz MmTSNlI{ODl7M{m=
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Mz-ChA-2 NH3PU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXVR2t5PzJiaB?= MkiyTWM2OD1|LkOxJI5O MnHaNlE6PjV5M{m=
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... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

文献中の引用 (52)

Frequently Asked Questions

  • Question 1
    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

    Answer: For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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