BI 2536 化学構造
分子量: 521.66

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Quality Control & MSDS

製品説明

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    PLK製品生物活性の比較
  • 研究分野
  • BI 2536のメカニズム

製品の説明

生物活性

製品説明 BI2536は、0.83nMのIC50による強力なポロのようなキナーゼ1(Plk1)阻害剤です。
ターゲット Plk1
IC50 0.83 nM [1]
In vitro試験 BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
PSN1 MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMEC3O|Yh|ryP MV7TRW5ITVJ?
ACN NHfCcnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEC4OFMh|ryP NVz6WGZoW0GQR1XS
TE-8 NFXERmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3mzUmlEPTB;MD6wNFk1OSEQvF2= M2TjbHNCVkeHUh?=
LC-2-ad NVqxNIE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TUdGlEPTB;MD6wNVA6OyEQvF2= MlTwV2FPT0WU
ALL-PO NXWyUlJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli3TWM2OD1yLkCxN{DPxE1? NUG3fnZYW0GQR1XS
EW-16 M3K4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLJeGFGUUN3ME2wMlAyOzN4IN88US=> MWXTRW5ITVJ?
KM12 NWDnWlZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEGzOFgh|ryP NGfJSndUSU6JRWK=
GI-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DTWWlEPTB;MD6wNVM5OyEQvF2= NI[wbWxUSU6JRWK=
LS-411N NWnpO5U6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEG0NFch|ryP NEHaZ|NUSU6JRWK=
ES8 M3v4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH1SHR7UUN3ME2wMlAyPDl2IN88US=> MX3TRW5ITVJ?
SNU-C2B NEK2T5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfjW3VKSzVyPUCuNFE2OjZizszN NEfTUFlUSU6JRWK=
CESS NUTBeI9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PHUWlEPTB;MD6wNVYxOiEQvF2= NHzad5RUSU6JRWK=
697 NIi5U3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPCOGgzUUN3ME2wMlAyPjZ6IN88US=> MYfTRW5ITVJ?
NCI-H1963 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLIW|FKSzVyPUCuNFE3PzNizszN NV3TTodnW0GQR1XS
IA-LM M2LIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfpV3UyUUN3ME2wMlAyPjh6IN88US=> MXLTRW5ITVJ?
SW954 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXJTWM2OD1yLkCxO|A2KM7:TR?= MmPZV2FPT0WU
RL95-2 NXyyeI52T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\6TWM2OD1yLkCxO|M5KM7:TR?= MXTTRW5ITVJ?
LXF-289 M37CcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFji[|BKSzVyPUCuNFE4PyEQvF2= NE\QOZhUSU6JRWK=
OCUB-M M1\PXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEG4NlYh|ryP NYThepNYW0GQR1XS
RKO Mo\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEG5PFch|ryP M3TRe3NCVkeHUh?=
LOUCY NH[z[GVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PIUGlEPTB;MD6wNlA2KM7:TR?= M1\YTnNCVkeHUh?=
NOS-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLrOpg6UUN3ME2wMlAzODl|IN88US=> MkL4V2FPT0WU
A4-Fuk MonNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEKyNVgh|ryP MY\TRW5ITVJ?
A388 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\WPHFjUUN3ME2wMlAzOjJ5IN88US=> NYXj[FN1W0GQR1XS
TE-9 NHrYe2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j4dWlEPTB;MD6wNlI3OSEQvF2= NULwPYpWW0GQR1XS
KURAMOCHI NHrlOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorpTWM2OD1yLkCyNlg2KM7:TR?= M3y1OnNCVkeHUh?=
KALS-1 MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHxVGpKSzVyPUCuNFI{OzhizszN NGDVcJpUSU6JRWK=
HOP-62 MoHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHiTJJKSzVyPUCuNFI1OiEQvF2= MVLTRW5ITVJ?
RPMI-8402 MorqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEK1NFgh|ryP MoT0V2FPT0WU
TE-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;qZ|dKSzVyPUCuNFI2OTJizszN NWLqTlB2W0GQR1XS
CCRF-CEM M3;zT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEK1OFMh|ryP NUnVPZdmW0GQR1XS
HUTU-80 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHwSFJKSzVyPUCuNFI3OjRizszN NVX6SJlDW0GQR1XS
NCI-H1648 MnnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jL[mlEPTB;MD6wNlY1PyEQvF2= NVv6THR[W0GQR1XS
HCE-4 NGDDO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLxNFB3UUN3ME2wMlAzPjh{IN88US=> NHzRUIVUSU6JRWK=
ETK-1 MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nIVGlEPTB;MD6wNlc{PiEQvF2= NUX3NlBkW0GQR1XS
TE-15 NEHoPXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3GwW2lEPTB;MD6wNlc{QCEQvF2= NVTrXGQ1W0GQR1XS
BE-13 NF35SXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LvNmlEPTB;MD6wNlc1KM7:TR?= NVr0S4oyW0GQR1XS
KE-37 NFLtflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[zbWZKSzVyPUCuNFI4PDFizszN NWKxWGY6W0GQR1XS
NCI-H1355 NWK2RnF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfSZ4xmUUN3ME2wMlAzPzh|IN88US=> M4XNSnNCVkeHUh?=
TE-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTBTWM2OD1yLkCyPFA6KM7:TR?= NYXpTGoyW0GQR1XS
BL-70 NHf6VlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q2VGlEPTB;MD6wNlg2PyEQvF2= M1zCRnNCVkeHUh?=
ES6 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4GzZ2lEPTB;MD6wNlg5OSEQvF2= M1;afnNCVkeHUh?=
GT3TKB MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\iNXl1UUN3ME2wMlAzQTV|IN88US=> M4PoN3NCVkeHUh?=
LB647-SCLC Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXOUHhuUUN3ME2wMlA{OTl3IN88US=> M1;te3NCVkeHUh?=
NB13 NVfk[JNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITqZYZKSzVyPUCuNFM{OTZizszN MkfOV2FPT0WU
ST486 NVz6N4UxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XaSGlEPTB;MD6wN|M{PyEQvF2= NHnRUoVUSU6JRWK=
NCI-H82 M1LvWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEOzOFMh|ryP M1\hTXNCVkeHUh?=
NTERA-S-cl-D1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEOzPVkh|ryP M2\heXNCVkeHUh?=
ES4 M{DXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmC5TWM2OD1yLkCzOFY{KM7:TR?= M2fhb3NCVkeHUh?=
SK-NEP-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEO0PVkh|ryP MmjpV2FPT0WU
Becker NY\MTGhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHWT4ZKSzVyPUCuNFM2PTVizszN M1ruVHNCVkeHUh?=
A101D M1PP[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEO3OFgh|ryP M13GOHNCVkeHUh?=
SK-UT-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\jTWM2OD1yLkCzO|c1KM7:TR?= NWDK[FkzW0GQR1XS
SW982 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\GR5RKSzVyPUCuNFM4QSEQvF2= NGTqeI9USU6JRWK=
TE-10 NUCyfI5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HUS2lEPTB;MD6wOFA1PiEQvF2= NUHwR3ZYW0GQR1XS
OVCAR-4 NWrCW2QzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG3TWM2OD1yLkC0NFU6KM7:TR?= MVHTRW5ITVJ?
KP-N-YS NG\MNGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnCb5FKSzVyPUCuNFQxQDVizszN NIi2UFJUSU6JRWK=
BL-41 Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMESxNlUh|ryP M1i5RnNCVkeHUh?=
MZ1-PC NVzOdJV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfMdW9ZUUN3ME2wMlA1OTJ5IN88US=> MW\TRW5ITVJ?
PF-382 MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXGfVllUUN3ME2wMlA1OTl6IN88US=> M3fJ[XNCVkeHUh?=
MOLT-13 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\0b|hKSzVyPUCuNFQzOzhizszN M2rYfnNCVkeHUh?=
HCC1599 NF\KXZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfrTWM2OD1yLkC0NlU5KM7:TR?= MlnkV2FPT0WU
IST-MEL1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPVe25RUUN3ME2wMlA1PDR{IN88US=> NXTHOZFtW0GQR1XS
LU-139 NW\ucoZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\KTJRtUUN3ME2wMlA1PDR{IN88US=> Mo\1V2FPT0WU
MS-1 NELhc4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmqwTWM2OD1yLkC0O|AyKM7:TR?= NF[y[GJUSU6JRWK=
MFH-ino NWPIcFNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7BTWM2OD1yLkC1NFA{KM7:TR?= M1j3ZXNCVkeHUh?=
IMR-5 NVTRTWxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUL6fWtxUUN3ME2wMlA2ODJzIN88US=> MXLTRW5ITVJ?
TE-5 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnxNVNKSzVyPUCuNFUxPjNizszN M{CxXnNCVkeHUh?=
DJM-1 NGPWd2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;ZemlEPTB;MD6wOVE1OiEQvF2= MkPGV2FPT0WU
NB17 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TE[WlEPTB;MD6wOVIxPyEQvF2= MXTTRW5ITVJ?
KARPAS-45 NVXaUJpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn73TWM2OD1yLkC1N|U5KM7:TR?= MYLTRW5ITVJ?
TGBC1TKB Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LYRWlEPTB;MD6wOVQxPSEQvF2= M3TBfXNCVkeHUh?=
ML-2 NWfnZpd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3pTWM2OD1yLkC1OFE1KM7:TR?= NVLGVoFZW0GQR1XS
no-10 M1rRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEW0O|Qh|ryP MVrTRW5ITVJ?
CTV-1 NYTSXGxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XjRWlEPTB;MD6wOVUxOiEQvF2= MnLSV2FPT0WU
SJSA-1 MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[0TWM2OD1yLkC1OVIh|ryP NEDSWVdUSU6JRWK=
HC-1 MlnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrFTWM2OD1yLkC1OVk4KM7:TR?= NFPVW5lUSU6JRWK=
TE-12 NF;qdHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn0WJlKSzVyPUCuNFU3OTNizszN M1XqOXNCVkeHUh?=
KY821 M4j0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLVSGZKSzVyPUCuNFU3OzJizszN M2TVXXNCVkeHUh?=
TALL-1 MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmSzTWM2OD1yLkC1O|A5KM7:TR?= MU\TRW5ITVJ?
DEL M2XZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVixN|c1UUN3ME2wMlA2PzB7IN88US=> NFO5cGRUSU6JRWK=
TE-6 M3qzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XHXWlEPTB;MD6wOVczOiEQvF2= MlzNV2FPT0WU
SK-LMS-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITKRY1KSzVyPUCuNFU5ODVizszN NFz0cGZUSU6JRWK=
EW-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnexTWM2OD1yLkC1PFM4KM7:TR?= M2\DPHNCVkeHUh?=
8-MG-BA M1jhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXwOnNLUUN3ME2wMlA2QDVzIN88US=> Mon6V2FPT0WU
NALM-6 M13DNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEW5O|Mh|ryP M1\SUXNCVkeHUh?=
LB771-HNC MlnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfDbINKSzVyPUCuNFU6PzlizszN M{HzWHNCVkeHUh?=
HT-144 M1ewWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlroTWM2OD1yLkC2NVMh|ryP NEfZZ4RUSU6JRWK=
KM-H2 NXrYN|E4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwME[yNlEh|ryP NGnsT|hUSU6JRWK=
SF268 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnlbXNUUUN3ME2wMlA3Ojh4IN88US=> MoS5V2FPT0WU
RS4-11 NHGyco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zubWlEPTB;MD6wOlMxPCEQvF2= M4XaTnNCVkeHUh?=
MHH-PREB-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF36VXpKSzVyPUCuNFY{OTlizszN Mn\rV2FPT0WU
ATN-1 NITkOIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwME[zOFUh|ryP M37HbnNCVkeHUh?=
BB30-HNC NG\4Rm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfxcVRwUUN3ME2wMlA3PDN4IN88US=> NGfDeGVUSU6JRWK=
CPC-N NH\XflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwME[1NlQh|ryP NI\qRmtUSU6JRWK=
NB1 NVPxOIhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDB[|dKSzVyPUCuNFY3OTNizszN NFW5W49USU6JRWK=
KS-1 NXjUZZZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC1fZNvUUN3ME2wMlA3PzR6IN88US=> NVXIRWZHW0GQR1XS
RXF393 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvtU3BIUUN3ME2wMlA3PzZ2IN88US=> NWq4R4I6W0GQR1XS
IST-SL2 M1zHcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTRTWM2OD1yLkC3NFA1KM7:TR?= MU\TRW5ITVJ?
GI-ME-N NVzWSGpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLNTWM2OD1yLkC3Nlg3KM7:TR?= NX\uSXJbW0GQR1XS
VA-ES-BJ M1G2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\iUYVZUUN3ME2wMlA4PDd3IN88US=> M3PGcHNCVkeHUh?=
NCI-H1581 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMEe0O|gh|ryP M{nxdXNCVkeHUh?=
U-266 NELSNWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vhWGlEPTB;MD6wO|Q6PyEQvF2= NU\Yb4pqW0GQR1XS
DMS-114 NGXpW4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPQ[|ZKSzVyPUCuNFc2OjhizszN Ml\EV2FPT0WU
NCI-H187 NVrKWIg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnw[VhKSzVyPUCuNFc4OjZizszN NHfIR2lUSU6JRWK=
SW962 NXG5R2NJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfG[llKSzVyPUCuNFc5OzlizszN Mm\5V2FPT0WU
MONO-MAC-6 Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrtTWM2OD1yLkC3PVg3KM7:TR?= M3jOW3NCVkeHUh?=
MOLT-16 M1jzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvpeYZKSzVyPUCuNFgyOjFizszN NGTVToFUSU6JRWK=
KNS-42 MoHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\JTWM2OD1yLkC4NVYyKM7:TR?= M1\0c3NCVkeHUh?=
CMK Mo\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn0U25KSzVyPUCuNFgzOjVizszN NYT2XnVRW0GQR1XS
Ramos-2G6-4C10 M{XFVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLsTWM2OD1yLkC4NlI2KM7:TR?= MVjTRW5ITVJ?
Daudi M4j6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP3W3BKSzVyPUCuNFgzPTZizszN MXjTRW5ITVJ?
NCI-H510A M1nNXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PYdmlEPTB;MD6wPFM{PiEQvF2= NXzNcIkzW0GQR1XS
LB831-BLC NXLMeHJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jydGlEPTB;MD6wPFU3OSEQvF2= MnjXV2FPT0WU
HEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK2NW9KSzVyPUCuNFg3PjhizszN NV;TOWdzW0GQR1XS
LU-134-A MonnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXPTWM2OD1yLkC4O|A5KM7:TR?= NFL1U3hUSU6JRWK=
NCI-H1694 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\zO5dRUUN3ME2wMlA5PzR2IN88US=> NGL0dnFUSU6JRWK=
KGN NIDiXIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnhUoRKSzVyPUCuNFg4PTlizszN NX23d4drW0GQR1XS
A253 NHjCT|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H3RWlEPTB;MD6wPFgzOiEQvF2= NGC5SWNUSU6JRWK=
DG-75 MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXqzd|ExUUN3ME2wMlA5QTJ{IN88US=> NHfCN2ZUSU6JRWK=
MOLT-4 NHnQXWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfnSY41UUN3ME2wMlA5QTh|IN88US=> NGW3UIhUSU6JRWK=
NCI-SNU-5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPISodKSzVyPUCuNFkzPThizszN MX;TRW5ITVJ?
ONS-76 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmC2TWM2OD1yLkC5Nlc3KM7:TR?= MlX1V2FPT0WU
NCI-H446 MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEm0OlIh|ryP NV70OnJ{W0GQR1XS
COR-L279 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEm1OVYh|ryP MWrTRW5ITVJ?
Calu-6 M1nLOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3TTWM2OD1yLkC5OVk5KM7:TR?= NFzlZ|RUSU6JRWK=
BC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X4Z2lEPTB;MD6wPVY3OiEQvF2= NF3Nb4lUSU6JRWK=
NCI-H2126 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;zTWM2OD1yLkC5O|kyKM7:TR?= NWXpdJB6W0GQR1XS
NCI-H1882 NVLB[3ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fkPWlEPTB;MD6wPVgxQSEQvF2= NGjXVFNUSU6JRWK=
BB65-RCC M{LydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fRZWlEPTB;MD6xNFI6PCEQvF2= NFLQVVJUSU6JRWK=
DU-4475 NFf1VohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj2NY5KSzVyPUCuNVA1ODdizszN NWHSdFR2W0GQR1XS
NCI-H526 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfab3E3UUN3ME2wMlExPDRizszN M1HCb3NCVkeHUh?=
NEC8 NGjlWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT6R2FKUUN3ME2wMlExPTJ3IN88US=> NV7IW49HW0GQR1XS
NCI-H1304 NUnWXZZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMUC1PVQh|ryP NVTTdXU1W0GQR1XS
L-540 MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NICxTGtKSzVyPUCuNVA4ODhizszN NIfX[WFUSU6JRWK=
NCI-SNU-16 NXv4bI1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMUC3OFIh|ryP NYH0O2FzW0GQR1XS
HD-MY-Z M3rYfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfWT|lKSzVyPUCuNVA5PTZizszN NYX4VFkxW0GQR1XS
K-562 NV[5eVVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMUC4OVgh|ryP MWPTRW5ITVJ?
JAR NHr1UJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfLTWM2OD1yLkGwPVI2KM7:TR?= NEe5dndUSU6JRWK=
MZ2-MEL NWTkemVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\2PGlEPTB;MD6xNVA2KM7:TR?= MXvTRW5ITVJ?
L-363 M4LMfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmzOHpKSzVyPUCuNVExPzlizszN MYrTRW5ITVJ?
BV-173 NYCyVYR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMUGyOFMh|ryP NX[ycVJyW0GQR1XS
NCI-H524 NGr6S4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPsbG9KUUN3ME2wMlEyOjd2IN88US=> NFe2SYhUSU6JRWK=
EoL-1-cell M4X3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMUG2O|Ih|ryP NXfwVWxnW0GQR1XS
K052 NUPycmluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDEO|lKSzVyPUCuNVE4OTJizszN M4fFR3NCVkeHUh?=
TK10 NWTTNGJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37mbmlEPTB;MD6xNVczQCEQvF2= MlP0V2FPT0WU
KU812 NUnXW5A6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XRd2lEPTB;MD6xNlA1PCEQvF2= NVLkN|FlW0GQR1XS
RPMI-8226 NWPCOYpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknxTWM2OD1yLkGyNFUzKM7:TR?= NIPWZ4RUSU6JRWK=
MZ7-mel M{mwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMUKyN|ch|ryP MUjTRW5ITVJ?
SK-PN-DW MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMUKyPFch|ryP M4fG[3NCVkeHUh?=
SR NF\Dc|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDGdm9KSzVyPUCuNVI1PDFizszN Mle3V2FPT0WU
RPMI-6666 MoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMUK3OFMh|ryP MVnTRW5ITVJ?
no-11 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[3UGlEPTB;MD6xNlg3QSEQvF2= MonzV2FPT0WU
EW-3 NGXDUYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P5VmlEPTB;MD6xNlg6OyEQvF2= MoTtV2FPT0WU
LAMA-84 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELaWFZKSzVyPUCuNVMyQDdizszN MoLDV2FPT0WU
HT NH7HOnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXIWFBkUUN3ME2wMlE{PTd2IN88US=> M4TYSHNCVkeHUh?=
KP-N-RT-BM-1 NV31WIYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\LcGNYUUN3ME2wMlE{PjF{IN88US=> M1X6[3NCVkeHUh?=
NCI-H747 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj4RY9KSzVyPUCuNVM4KM7:TR?= MlrzV2FPT0WU
NCCIT MkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDmTWM2OD1yLkGzPVM6KM7:TR?= MV3TRW5ITVJ?
MLMA Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnUTWM2OD1yLkG0NVY4KM7:TR?= MlfWV2FPT0WU
LP-1 NG\3RW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nzXmlEPTB;MD6xOFI1KM7:TR?= MnewV2FPT0WU
CAL-148 Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMUS0PFMh|ryP M{f2S3NCVkeHUh?=
GB-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHwe|lLUUN3ME2wMlE1PTJ4IN88US=> M2LSeHNCVkeHUh?=
COR-L88 M{nTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHBWpdVUUN3ME2wMlE1QDB{IN88US=> MY\TRW5ITVJ?
NKM-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\wS2lEPTB;MD6xOFkxPiEQvF2= M3HYVXNCVkeHUh?=
NB5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjrTWM2OD1yLkG1OFYzKM7:TR?= NEXVdJJUSU6JRWK=
SH-4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PoWGlEPTB;MD6xOVQ3PiEQvF2= M4DlNnNCVkeHUh?=
EM-2 NXHiRmV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[xfG9iUUN3ME2wMlE2PDZ5IN88US=> NFPrNWJUSU6JRWK=
TGBC24TKB NELUOmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn2c3NKSzVyPUCuNVU3PTlizszN M4fifHNCVkeHUh?=
SCLC-21H NXf6SmlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDJVlF5UUN3ME2wMlE2PzB{IN88US=> MV7TRW5ITVJ?
COLO-684 Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSyTWM2OD1yLkG1O|IyKM7:TR?= Mnv6V2FPT0WU
KINGS-1 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvJUJJKSzVyPUCuNVU6OSEQvF2= Mk\tV2FPT0WU
LS-123 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHT[mN3UUN3ME2wMlE2QTF5IN88US=> NEmxepFUSU6JRWK=
MC116 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;6XpVTUUN3ME2wMlE3OTV6IN88US=> NH\zPJlUSU6JRWK=
SU-DHL-1 MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq4NmpKSzVyPUCuNVYzODZizszN Mmq3V2FPT0WU
NCI-H64 MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;DemlEPTB;MD6xOlM1PyEQvF2= M1exRXNCVkeHUh?=
HCE-T MoXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:1NWlEPTB;MD6xOlUxPCEQvF2= MkjmV2FPT0WU
LOXIMVI NHTqRlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2m2OWlEPTB;MD6xOlk1QSEQvF2= MoTqV2FPT0WU
ARH-77 Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\JTnh6UUN3ME2wMlE4Ozd7IN88US=> MmXiV2FPT0WU
DOHH-2 MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfUcnFKSzVyPUCuNVc3PzJizszN NH3xO5lUSU6JRWK=
COLO-320-HSR NGf5UIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13SdmlEPTB;MD6xPFE2PCEQvF2= NGHnNIVUSU6JRWK=
NB6 M2XnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDON415UUN3ME2wMlE5PTZ4IN88US=> MWrTRW5ITVJ?
L-428 NXXjbmN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMUi4NVMh|ryP NIjkNG9USU6JRWK=
SNB75 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLITWM2OD1yLkG4PFI1KM7:TR?= MXrTRW5ITVJ?
NCI-H2141 NGjKW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMUmwNVEh|ryP M1ewbHNCVkeHUh?=
KARPAS-299 MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD2PWZVUUN3ME2wMlE6OjRzIN88US=> MoW3V2FPT0WU
LC4-1 NX7GNXdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW2cmxKSzVyPUCuNVk2ODJizszN M1:2N3NCVkeHUh?=
UACC-257 M2q2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEi3Z2VKSzVyPUCuNVk6PDdizszN NXWwOHNSW0GQR1XS
EVSA-T MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfTdJBDUUN3ME2wMlIxOzF{IN88US=> MknBV2FPT0WU
JiyoyeP-2003 MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K4UmlEPTB;MD6yNFQ4PyEQvF2= NU\NWXUzW0GQR1XS
NCI-H720 NYLZ[Ix7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rnXWlEPTB;MD6yNFUzPSEQvF2= NYTRXlhQW0GQR1XS
GAK NX\1Z5dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHETWM2OD1yLkKxNVg6KM7:TR?= MYPTRW5ITVJ?
HH M3LiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHtd4JKSzVyPUCuNlE1ODVizszN M2KyOHNCVkeHUh?=
NCI-H1436 NGT6WmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXNPY1KSzVyPUCuNlE1PjRizszN MmfpV2FPT0WU
GR-ST MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPYblJPUUN3ME2wMlIyPDh6IN88US=> NIHpNHlUSU6JRWK=
BC-1 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMkK2NVYh|ryP NXnvfGhlW0GQR1XS
SIG-M5 NVzQVVlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXhW2JFUUN3ME2wMlIzPzJ5IN88US=> NIjGW|BUSU6JRWK=
NCI-H345 NHK1TG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMkO4NFUh|ryP NYXFRZZVW0GQR1XS
OPM-2 NF:5U|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnexTWM2OD1yLkKzPFgzKM7:TR?= MU\TRW5ITVJ?
LB1047-RCC NVXvR2NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMkS0NUDPxE1? MXzTRW5ITVJ?
CTB-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDqTWM2OD1yLkK0OFk{KM7:TR?= M3i0T3NCVkeHUh?=
A3-KAW NXXqOVhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjVTWM2OD1yLkK1N|QyKM7:TR?= NH3ZcWJUSU6JRWK=
SF126 NHyz[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTKRVhKSzVyPUCuNlU{QDNizszN MoHOV2FPT0WU
KARPAS-422 NEnZcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqycnpKSzVyPUCuNlU1OzVizszN MWfTRW5ITVJ?
MEG-01 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm4TWM2OD1yLkK1Olc{KM7:TR?= M2jVV3NCVkeHUh?=
NCI-H209 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvuTWM2OD1yLkK2N|c1KM7:TR?= MV3TRW5ITVJ?
SBC-1 M3nzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDr[mRzUUN3ME2wMlI3PSEQvF2= NH7NWZlUSU6JRWK=
K5 NH;3WldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT1TWM2OD1yLkK2PVg1KM7:TR?= Ml;MV2FPT0WU
QIMR-WIL MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMkexOVUh|ryP NHTlOWFUSU6JRWK=
NMC-G1 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3wTWM2OD1yLkK4NlE4KM7:TR?= M3L5c3NCVkeHUh?=
IST-MES1 NVe3cIt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMkmyN|gh|ryP M374T3NCVkeHUh?=
SW684 MmjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4npNWlEPTB;MD6zNFA1PyEQvF2= MYXTRW5ITVJ?
MV-4-11 NYW1bFZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XWe2lEPTB;MD6zNFc5QCEQvF2= MXzTRW5ITVJ?
LAN-6 NIrBNZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13YOmlEPTB;MD6zNVU4OiEQvF2= M3\lN3NCVkeHUh?=
RH-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwM{G4O|Eh|ryP M17WenNCVkeHUh?=
CP66-MEL MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXOd3BGUUN3ME2wMlMyQDd6IN88US=> MlLRV2FPT0WU
EC-GI-10 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3rU3lKSzVyPUCuN|I6QDdizszN NHrhcGFUSU6JRWK=
GDM-1 MnHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFi4XFJKSzVyPUCuN|MxPTlizszN M4K2c3NCVkeHUh?=
IST-SL1 NEK0XmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwM{S5NVQh|ryP MVnTRW5ITVJ?
KMOE-2 NUXzbm9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfxTWM2OD1yLkO1NVc2KM7:TR?= M3vQTXNCVkeHUh?=
OS-RC-2 NIn5ZWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G1UmlEPTB;MD6zOVU1PCEQvF2= MXPTRW5ITVJ?
HDLM-2 M1S0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvVTlVKSzVyPUCuN|c5OTRizszN NH;JVYJUSU6JRWK=
DSH1 NYrnd3I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLxTWM2OD1yLkO4OlMyKM7:TR?= NXGyXXpRW0GQR1XS
LS-1034 NV3pcGVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrTR25CUUN3ME2wMlM5QTV2IN88US=> NFjKeo1USU6JRWK=
LB373-MEL-D Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj3VZZGUUN3ME2wMlM6OTl5IN88US=> M{HLcnNCVkeHUh?=
GOTO MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfkTWM2OD1yLkSyNVE5KM7:TR?= MkjXV2FPT0WU
MRK-nu-1 M1r6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe2e2d7UUN3ME2wMlQzOjB3IN88US=> MnPpV2FPT0WU
SK-MM-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\2XplKSzVyPUCuOFM1PDJizszN NH3PcHlUSU6JRWK=
BOKU MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7lXmc6UUN3ME2wMlQ{Pzl{IN88US=> MYjTRW5ITVJ?
NOMO-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fNSmlEPTB;MD60N|g3KM7:TR?= MmPvV2FPT0WU
J-RT3-T3-5 NIPzVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTLS5FKSzVyPUCuOFQ5PzhizszN NF7TWnBUSU6JRWK=
COLO-668 NYPR[YxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jieWlEPTB;MD60OVY3QCEQvF2= NUH4dGg3W0GQR1XS
SF539 NHrlelZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLUTnVLUUN3ME2wMlQ5Pjh2IN88US=> MY\TRW5ITVJ?
LB2518-MEL MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPldVIzUUN3ME2wMlQ6PzB|IN88US=> M2jGZnNCVkeHUh?=
TE-441-T NFjFVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTxTWM2OD1yLkWwNVIh|ryP MnHNV2FPT0WU
MDA-MB-134-VI MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXscY9KSzVyPUCuOVA6OjFizszN MY\TRW5ITVJ?
SCC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIGwRYdKSzVyPUCuOVE5PzNizszN NFntZYtUSU6JRWK=
KLE M1X2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXrTWM2OD1yLkWyNVcyKM7:TR?= M4jUR3NCVkeHUh?=
LB2241-RCC NWLR[3FwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLsZVAxUUN3ME2wMlUzPTJ3IN88US=> M{W2NXNCVkeHUh?=
NCI-H1417 NUHPfFFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXKV3FHUUN3ME2wMlU{PDN3IN88US=> MXHTRW5ITVJ?
NCI-H2081 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjwd3RKSzVyPUCuOVg3OTFizszN M3G3fXNCVkeHUh?=
NCI-H1522 M1LLRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnEbYFUUUN3ME2wMlU6Ozh|IN88US=> MV3TRW5ITVJ?
NCI-H889 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLmTWM2OD1yLkW5PFQ1KM7:TR?= Ml7LV2FPT0WU
CGTH-W-1 NV\yVHFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwNkC3OVUh|ryP NIj5eVZUSU6JRWK=
EB-3 MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwNkGxOVMh|ryP MkHXV2FPT0WU
D-336MG M2\EWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;0SJRKSzVyPUCuOlE4QTFizszN NWnx[GxlW0GQR1XS
LC-1F NX7NflNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLPTWM2OD1yLk[yOVkzKM7:TR?= MnTQV2FPT0WU
MHH-NB-11 NEXjU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz4WZdDUUN3ME2wMlY{QDBzIN88US=> M4\6PHNCVkeHUh?=
SK-N-FI NUPoeXJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;mOmlEPTB;MD62N|kyKM7:TR?= NUnzXnFiW0GQR1XS
NCI-H69 NVLCeVBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPnTWM2OD1yLk[0PFc6KM7:TR?= MYjTRW5ITVJ?
SCH NHW0VlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\LZmlEPTB;MD62OlAzOyEQvF2= MoH6V2FPT0WU
LS-513 MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETNXnlKSzVyPUCuOlczPTlizszN NU\tdo9IW0GQR1XS
CP67-MEL M2LUPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojFTWM2OD1yLk[3OVk3KM7:TR?= NYjBVGp7W0GQR1XS
GCIY MlfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z5fmlEPTB;MD63NFM3OyEQvF2= MnzsV2FPT0WU
SHP-77 NGLjRnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPLfmNMUUN3ME2wMlcxPzN2IN88US=> NYr4fIltW0GQR1XS
EHEB MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLTfoQ1UUN3ME2wMlcyQDV2IN88US=> MUHTRW5ITVJ?
D-247MG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf6RpFMUUN3ME2wMlc{OjN{IN88US=> MVrTRW5ITVJ?
Raji NWi1O4toT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDjTWM2OD1yLke0PVg6KM7:TR?= MXXTRW5ITVJ?
MPP-89 NFrpXXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnDWpcxUUN3ME2wMlc2QTd6IN88US=> NV3Dd4VnW0GQR1XS
EKVX M2nYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DDeWlEPTB;MD63PVA4OyEQvF2= MYjTRW5ITVJ?
HCC2218 MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP1V4NFUUN3ME2wMlc6OTNzIN88US=> M{XjUHNCVkeHUh?=
KNS-81-FD NGHzblhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrWRoV[UUN3ME2wMlgyODFzIN88US=> NFfNd4pUSU6JRWK=
HCC2157 M{HVemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\hPGpKSzVyPUCuPFQ6PTFizszN NWG4O5JHW0GQR1XS
BT-474 NV3RS3JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwOEi4OVQh|ryP Mk\3V2FPT0WU
NCI-H748 M{frR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwOUGyJO69VQ>? MlHsV2FPT0WU
EW-24 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX6Z3RKSzVyPUCuPVIxODJizszN M{jXXnNCVkeHUh?=
D-263MG NITZW4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zyXWlEPTB;MD65OFUyOiEQvF2= NFXLc|hUSU6JRWK=
OMC-1 NEfjU45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkewTWM2OD1yLkm2N|c{KM7:TR?= NEHBV5ZUSU6JRWK=
NCI-H2196 NWjZdYZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LlRmlEPTB;MD65O|c4PyEQvF2= MXXTRW5ITVJ?
HAL-01 M1nYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zGRmlEPTB;MD65PVg4OiEQvF2= NETV[4hUSU6JRWK=
NCI-H2107 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnSTWM2OD1zLkCxPFU1KM7:TR?= NVTLdldyW0GQR1XS
LB996-RCC NVnDXZNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDUTWM2OD1zLkC4NFUyKM7:TR?= M2r2XXNCVkeHUh?=
NCI-H1395 MnriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzvc4RJUUN3ME2xMlExPjdizszN NUP5[JpoW0GQR1XS
CHP-126 NFzocXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnu5TWM2OD1zLkG2NVk6KM7:TR?= M2XDV3NCVkeHUh?=
NB69 M33sOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLrTWM2OD1zLkK2NVQ5KM7:TR?= NYXMcZQ{W0GQR1XS
CAS-1 M1LHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTuTWM2OD1zLkO0NlMyKM7:TR?= NV\USoU4W0GQR1XS
JVM-3 NV3Femx7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTFwNEe4OVUh|ryP Ml3CV2FPT0WU
DMS-153 NYLWbZpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFwNUe2O|Qh|ryP MmrKV2FPT0WU
SK-MEL-2 M4Lu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3B[plRUUN3ME2xMlcyPzh7IN88US=> M4fLe3NCVkeHUh?=
NCI-H1155 NXXZO3BiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnj6TWM2OD1zLkezOlc3KM7:TR?= MXjTRW5ITVJ?
NCI-H1092 MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFwN{[xPFIh|ryP NXmwPVNRW0GQR1XS
LU-165 NWPPRZJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFwOE[0O|Yh|ryP MVLTRW5ITVJ?
HL-60 NW\4U5FvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[0c|VLUUN3ME2xMlk6QTB6IN88US=> MXzTRW5ITVJ?
REH MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlOzTWM2OD1{LkCwOVgzKM7:TR?= Ml;LV2FPT0WU
JVM-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfpWXVjUUN3ME2yMlA3OTN3IN88US=> NYWxUYxjW0GQR1XS
MN-60 MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq1SItHUUN3ME2yMlE4OzB6IN88US=> MYfTRW5ITVJ?
SCC-15 NGnQW4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJwMkCyO{DPxE1? MYTTRW5ITVJ?
SNU-C1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHuSGdKSzVyPUKuNlE{PDNizszN MY\TRW5ITVJ?
SK-MEL-1 NGT5RXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XqUmlEPTB;Mj6zNlA1PyEQvF2= NWfibGVnW0GQR1XS
TGW NW\mRVh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X4R2lEPTB;Mj6zOVAzPyEQvF2= NXWxT5oyW0GQR1XS
CA46 NF76NXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q1emlEPTB;Mj63OVk3PyEQvF2= MWXTRW5ITVJ?
NCI-H23 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJwOEC3PVEh|ryP M3i5RnNCVkeHUh?=
MMAC-SF NXL4WWtnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:0OmxKSzVyPUKuPFY3OjhizszN MWTTRW5ITVJ?
NCI-H2171 NVLhdGNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTNwMEO0OFgh|ryP NVjYW4VmW0GQR1XS
A704 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoCxTWM2OD1|LkG0NVk1KM7:TR?= MXvTRW5ITVJ?
DB NIr6OnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fZN2lEPTB;Mz6yOVU4PiEQvF2= NXHEfYhFW0GQR1XS
NCI-H719 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTNwM{CzPFQh|ryP NWjnWHhHW0GQR1XS
MC-CAR MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfPSZFKSzVyPUOuOVQ5OTdizszN NUDBc4JQW0GQR1XS
SIMA NYr5TW01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPE[XRDUUN3ME2zMlU5PDF4IN88US=> MnfoV2FPT0WU
SW872 NUL0cWtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDQOVRvUUN3ME2zMlc5OTBzIN88US=> NVX3VZRNW0GQR1XS
HCC1187 M{\jW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXVcZZKSzVyPUOuO|g{OTVizszN Mme4V2FPT0WU
EW-13 Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTNwOEO0NVch|ryP MXrTRW5ITVJ?
NCI-SNU-1 M1r2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW4bJU4UUN3ME20MlIyQTl7IN88US=> NITVR|RUSU6JRWK=
NCI-H226 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTRwM{O2NFYh|ryP MWHTRW5ITVJ?
RPMI-8866 MkDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXRUpRKSzVyPUSuN|YxOjlizszN NIHHV3RUSU6JRWK=
OCI-AML2 M2W5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInib3dKSzVyPUSuOVUzOyEQvF2= MYHTRW5ITVJ?
LU-65 NF3GXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTRwOUOwN|Mh|ryP NG\nNnBUSU6JRWK=
SK-N-DZ Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:wNVZKSzVyPUWuOlM1PjVizszN NH;BWoJUSU6JRWK=
NB14 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;wdVY{UUN3ME21Mlk4OTN3IN88US=> NVvhSZBTW0GQR1XS
COLO-829 NWrNWWlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnLPIhKUUN3ME22MlM{OzV7IN88US=> NYjGTopIW0GQR1XS
MHH-CALL-2 NVjUPHZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XLXGlEPTB;Nj61NVUxQCEQvF2= MVXTRW5ITVJ?
NCI-H1770 NY[wOHJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTZwNk[5NFQh|ryP MWTTRW5ITVJ?
ECC4 NX;oOphrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTZwOEKxO|kh|ryP NFK0OWdUSU6JRWK=
A498 NHnsXG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrjTWM2OD14Lki3NVkzKM7:TR?= MmLUV2FPT0WU
DMS-79 M{fMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrsSHVKSzVyPUeuNFQ2OTJizszN MWrTRW5ITVJ?
P30-OHK MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf1TWM2OD15LkKxPVA3KM7:TR?= M{fDdXNCVkeHUh?=
D-502MG NHexU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nvdWlEPTB;Nz65PFM3KM7:TR?= M1vPdHNCVkeHUh?=
RCC10RGB NETBc4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRThwME[yPEDPxE1? MX7TRW5ITVJ?
U-698-M NFfkb2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\jTWM2OD16LkK5NlI3KM7:TR?= M1jU[3NCVkeHUh?=
BB49-HNC NIDCeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDZUVhXUUN3ME25MlQzOjZ3IN88US=> NY\FSGJCW0GQR1XS
ES1 M2T2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTlwNki5OVYh|ryP NULNdpBoW0GQR1XS
MFM-223 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;Te5lFUUN3ME2xNE46QTJ5IN88US=> NGDGd5VUSU6JRWK=
C2BBe1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHSfIdKSzVyPUGxMlM2OjNizszN MWDTRW5ITVJ?
EB2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTF{Lk[4PFEh|ryP M{PmXnNCVkeHUh?=
C8166 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfIcnVvUUN3ME2xN{45OzB|IN88US=> NU[zOIlDW0GQR1XS
ES3 M2HqNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK0R5N2UUN3ME2xN{46QTd5IN88US=> Ml7jV2FPT0WU
NCI-H1650 M{Hh[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULQZVBqUUN3ME2xOk4{PzZ3IN88US=> NEP3[XRUSU6JRWK=
Mo-T M4C0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF5LkSwNlkh|ryP MkXPV2FPT0WU
NB7 MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2G2ZWlEPTB;MUeuO|Q3PyEQvF2= M4HUOXNCVkeHUh?=
ES7 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTMTWM2OD1zOT61OVA4KM7:TR?= NILNWYRUSU6JRWK=
ES5 M2L4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJzLke2O|Eh|ryP NFnQOItUSU6JRWK=
MSTO-211H NWfZcJY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJzLki4OVgh|ryP M17ubnNCVkeHUh?=
U-87-MG NI\KbHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjZ[XRwUUN3ME2yOU4yQTZ4IN88US=> MVLTRW5ITVJ?
THP-1 Mn71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17yOWlEPTB;MkmuO|IxOSEQvF2= NHjFeoRUSU6JRWK=
NB10 NFjxb|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfyVoxEUUN3ME2zNE4zPjl2IN88US=> MormV2FPT0WU
NH-12 NGHzc5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfSPFZwUUN3ME2zN{4zODF5IN88US=> MVPTRW5ITVJ?
COLO-824 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3aUHZKSzVyPUO0MlExODZizszN NYDGTXRmW0GQR1XS
SKM-1 NGXaOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUm1TVJQUUN3ME2zO{45PDJ{IN88US=> Ml3uV2FPT0WU
NCI-H1838 NGW4TYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTN6LkO3PVch|ryP MVjTRW5ITVJ?
RL MnvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Dqe2lEPTB;M{muNlQ4PyEQvF2= NYHFVnZVW0GQR1XS
COLO-800 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV36VZFIUUN3ME20NE4xPzd|IN88US=> NIfKWIpUSU6JRWK=
KG-1 MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7oRW1KSzVyPUSwMlg6PTVizszN M3jNWHNCVkeHUh?=
TUR MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrsTWM2OD12MT62N|k6KM7:TR?= MlPpV2FPT0WU
LNCaP-Clone-FGC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTXTWM2OD12MT65NFE4KM7:TR?= M4HkWHNCVkeHUh?=
NCI-H322M MkK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfESYNmUUN3ME20Nk42QTh2IN88US=> NXHFNo41W0GQR1XS
LNCaP  NYPwboczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[2[WlEPTB;OUGuN{BvVQ>? MnrVNlU2ODVzN{S=
C4-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fINmlEPTB;ODDuUS=> MVqyOVUxPTF5NB?=
JURKAT MlTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTKfZZ[OjRiaB?= NY\lcndmUUN3ME20NVYvPjZibl2= NF3RcHozPDVzOUm5OS=>
MOLT-4 MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LEVlI1KGh? NHHKV3lKSzVyPUK4OVMvPSCwTR?= NHnnZXQzPDVzOUm5OS=>
REH NEDDfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HMWVI1KGh? MX3JR|UxRTJ6Nz62PEBvVQ>? Ml\4NlQ2OTl7OUW=
NALM-6 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\iVJAzPCCq M3vNemlEPTB;M{SzN|Ahdk1? MoH5NlQ2OTl7OUW=
RS 4;11 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLiNlQhcA>? NUDDNlBSUUN3ME21NVkvODVibl2= MXOyOFUyQTl7NR?=
697 NV[2fHZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV6yOEBp M2XzUGlEPTB;MkGwO{4yKG6P M{LjfVI1PTF7OUm1
SIL-ALL M1LFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTVNlQhcA>? M{XLd2lEPTB;MUm5Mlc4KG6P NEfhRZkzPDVzOUm5OS=>
CEM NELafJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG3cnMzPCCq NVzzTVN4UUN3ME21Nk4yQCCwTR?= MYCyOFUyQTl7NR?=
P12 NHjpdmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfFdmwzPCCq NVL4Rpp5UUN3ME2zPU4zPyCwTR?= NW\3dFBsOjR3MUm5PVU>
NALM-16 MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknSNlQhcA>? NHPQUJpKSzVyPUm2MlI5KG6P NVqzV4gxOjR3MUm5PVU>
JURKAT MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYq0PEBp NFzWSppKSzVyPUG0Mlg1KG6P NFHhSYYzPDVzOUm5OS=>
MOLT-4 NGexflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nP[|Q5KGh? M{DtdGlEPTB;Mk[uOkBvVQ>? M{\TU|I1PTF7OUm1
REH NHjuNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfBfoFyPDhiaB?= MWXJR|UxRTR2LkexJI5O M4ezXlI1PTF7OUm1
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SIL-ALL M4f3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7OOFghcA>? NG\sUI9KSzVyPUe0MlYzKG6P M3PYfFI1PTF7OUm1
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JURKAT NFfPSm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO3NkBp MX3JR|UxRTNwNkWgcm0> NFewVpIzPDVzOUm5OS=>
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NALM-6 M{\FTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUS3NkBp M{HZOWlEPTB;MT63PEBvVQ>? NGX6XmszPDVzOUm5OS=>
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SIL-ALL MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzTb2g4OiCq MVfJR|UxRTdwMjDuUS=> MlHFNlQ2OTl7OUW=
CEM MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIKz[Fc4OiCq NFXuNINKSzVyPUWuOFIhdk1? NWexZZNCOjR3MUm5PVU>
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NALM-16 NFHYfY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYC3NkBp NULSN3dZUUN3ME23O{44OyCwTR?= NXvubph7OjR3MUm5PVU>
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WER-Rb-1 MX3BdI9xfG:|aYOgRZN{[Xl? MkPaNU02OCCwTR?= MVixNk8zPCCq NF;t[45FVVOR MmnKbY5lfWOnZDDhdI9xfG:|aYOge4hq[2hiY3HuJIJmKGWwaHHuZ4VlKGK7IFjU NF7tc4czPDN4Nk[2OS=>
G7 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LPO2lEPTB;Mz6zJI5O M3j4OVI1OjB2N{Oz
G166 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTdwMDDuUS=> MWqyOFIxPDd|Mx?=
CB660 NV36[Wx[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{i1[mlEPTB;Nj60JI5O NIL6[IMzPDJyNEezNy=>
CB1117 NGjnb|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe2b49KSzVyPUG1MlYhdk1? NVPxSlU6OjR{MES3N|M>
KB-3-1 NGL4NmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXSxPVk3UUN3ME2xMlQ5KMLzIECuOVMhdk1? MX6yN|k3OjR2NR?=
KB-8-5-11 Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrTU4I5UUN3ME21MlAyKMLzIEKuNFEhdk1? MlXoNlM6PjJ2NEW=
KB-C-1 NXvFOXIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTF4Lke2JOKyKDRwNUGgcm0> NEjNV4wzOzl4MkS0OS=>
KB-V-1 M4PV[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJ6MT6yOEDDuSB|MT61O{BvVQ>? NXHRSYVqOjN7NkK0OFU>
OVCAR-8 MofES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHOwb|JKSzVyPUeuNVkhyrFiMz62NEBvVQ>? NVPDXm5FOjN7NkK0OFU>
NCI-ADR-RES MlfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDXTWM2OD1zMkezMlMxKMLzIEG5NU4zOCCwTR?= M17ycVI{QTZ{NES1
MCF7 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7OUWpmUUN3ME21MlEyKMLzIEGuOFchdk1? MX[yN|k3OjR2NR?=
MCF7-FLV1000 Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzJeWRKSzVyPUO5N{4yQCEEsTC3OE45OyCwTR?= M4\jb|I{QTZ{NES1
S1 NVm3ZXJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LQW2lEPTB;MkSuN|AhyrFiND63OUBvVQ>? NETDWpIzOzl4MkS0OS=>
S1-M1-80 NEjnbnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofaTWM2OD1{NkGuNFYhyrFiNEiuNlUhdk1? NUXQcGlPOjN7NkK0OFU>
CORL-23/P MlfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorBTWM2OD12LkO4JOKyKDFwMkWgcm0> MmrqNlM6PjJ2NEW=
CORL-23/R MoXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XUVWlEPTB;NT6xOkDDuSBzLkizJI5O MmT5NlM6PjJ2NEW=
NIH3T3 NH;RR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT0VIFJUUN3ME20NE43OCEEsTC0Mlk4KG6P NVi4ZZlMOjN7NkK0OFU>
NIH3T3-G185 NYPjbVhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LPN2lEPTB;MkSxN{41OCEEsTC0NlMvPjZibl2= NEjv[oYzOzl4MkS0OS=>
pcDNA-HEK293 NIPISmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL2OJpSUUN3ME2yMlc2KMLzIECuOlchdk1? M{TpXVI{QTZ{NES1
MDR19-HEK293 NFLZRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHhV2dKSzVyPUi1MlUxKMLzIEGzMlY4KG6P MmXZNlM6PjJ2NEW=
R482-HEK293 NV7pd4NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nsVmlEPTB;MkWuPVchyrFiND65OUBvVQ>? MmjGNlM6PjJ2NEW=
MRP1-HEK293 NYr4bld1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHLNI5KSzVyPUKuPVkhyrFiMT60PUBvVQ>? NXKxUo02OjN7NkK0OFU>
SF188 NH7ZcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfpNVAuOTByIH7N MXeyOE06PiCq NInCfWhFVVOR M3POcolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZT2gZY5lKGOxbnPlcpRz[XSrb36tJIRmeGWmZX70JI1idm6nch?= Mme5NlM5QDd4NEW=
T98G MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrxPXEyOC1zMECgcm0> NWfVO|gzOjRvOU[gbC=> NFXpTWZFVVOR NHnxUFRqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDjc45k\W62cnH0bY9vNSCmZYDl[IVvfCCvYX7u[ZI> MVGyN|g5PzZ2NR?=
DU145 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vtUmROW09? MnTlTWM2OOLKvE[wJI5O Mn7RNlM5QDR2Mki=
LNCaP  M{DX[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7tc5FJTE2VTx?= MX3JR|Ux6oj:N{Wgcm0> M1vYbVI{QDh2NEK4
PC3 NF3NeVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPEUXNQ MWTJR|Ux6oj:MUe1JI5O M2S5[VI{QDh2NEK4
RT4 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTWTWM2OD1{Nz6yNUBvVQ>? NHzwNmYzOzd7Mk[zPS=>
5637 M3f5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf2SWZ[UUN3ME20OU41PyCwTR?= MWKyN|c6OjZ|OR?=
T24 MmLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHlTWM2OD15OT6xNkBvVQ>? Mn\pNlM4QTJ4M{m=
MCF7  M33SZmZ2dmO2aX;uJGF{e2G7 NUXiT2NpOTByIH7N MYKxJIg> MlSySG1UVw>? MUTy[YR2[2W|IITo[UBqdmS3Y4Tpc44hd2cEoFfy[YIyNMLiU3frNUzDqFC|Mj|CpHNmenCrbnGzMEBidmUEoGfpd5Az MWiyN|c4ODJ2NB?=
KB-V1  NGLkR|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj4R2xKSzVyPUOuPVIh|ryP NYSxZ3BZOjN3OUOxPVY>
Hec50co NEnqVG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XCdWlEPTB;NTDuUS=> MV:yN|E1PjZ6Nx?=
MDA-MB-468 NGHXbVdCeG:ydH;zbZMhSXO|YYm= NXvZbFlXOS93L{GwJI5O NFnVWHEzPC92OD:3NkBp MmnXSG1UVw>? MYfpcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M372WlI{OTR2Mkm0
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MDA-MB-231 NFLZXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK4NE0yODBibl2= MVK3NkBp MX\pcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= MYiyNlMxQTl|OR?=
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BT-474-M1 MlPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;adnpXOC1zMECgcm0> M1HRdVczKGh? NHLUfHVqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> Mor6NlI{ODl7M{m=
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TGBC1-TKB MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2K2[|E1PCCq MXzJR|UxRTZwN{Kgcm0> MWWyNVk3PTd|OR?=
Wittier NUnwe3VFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHiPYRnPzJiaB?= MW\JR|UxRTNwMk[gcm0> Mk[2NlE6PjV5M{m=
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EGI-1 NVPub3hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7SVGs3PzJiaB?= NH;CS5JKSzVyPUGwMlczKG6P MVyyNVk3PTd|OR?=
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HMC-1.2 NXrmPJprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7wTWpWOS1zMECwJI5O NInZZ3M4OiCq NGT0OW9qdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? NV\nNIpEOjF{NEKxPFk>
C2 M2m3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWGxMVExODBibl2= Ml25O|IhcA>? M2q5W4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\Q>? NYLWR|VoOjF{NEKxPFk>
CHP-212 NVjLe5VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLBNU0yOjVibl2= M1LN[VI1NTF{MDDo MmTjbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= MWSyNVE3QTJ2Mh?=
IMR-32 NWjLToJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjHSI5mOS1zMkWgcm0> MUmyOE0yOjBiaB?= M2\u[4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= M1HGXFIyOTZ7MkSy
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... Click to View More Cell Line Experimental Data

In vivo試験 BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]
臨床試験 A Phase II study of BI 2536 infusional treatment in patients over 60 years of age with refractory or relapsed acute myeloid leukaemia has been completed.
特集 The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Plk1 in vitro kinase assay Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.

細胞アッセイ: [1]

細胞株 HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
濃度 Dissolved in DMSO, final concentrations ~1 μM
反応時間 24 and 72 hours
実験の流れ Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.

動物実験: [1]

動物モデル Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
製剤 Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
投薬量 ~50 mg/kg
投与方法 Injection i.v. once or twice per week

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BI 2536 SDF
分子量 521.66
化学式

C28H39N7O3

CAS No. 755038-02-9
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 21 mg/mL (40.25 mM)
エタノール 100 mg/mL (191.69 mM)
<1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

カスタマーフィードバック (10)


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Source Cancer Cell , 2010, 18, 641–654. BI 2536 purchased from Selleck
Method Immunohistochemical analysis
Cell Lines SCID mice
Concentrations
Incubation Time
Results Control tumors grow exponentially, whereas genetic ablation of Cdc20 results in complete tumor regression in about 10 days. In comparison, treatment with taxol, vincristine, and BI2536 only induces partial responses ( Figure C). In agreement with the data observed in vitro, immunohistochemical analysis of samples taken 3 days after the first treatment indicates lack of proliferation (as measured by BrdU incorporation) and massive apoptosis in Cdc20 null cells, whereas all other samples maintain significant levels of proliferation and reduced apoptotic markers ( Figure D)

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Source Nat Cell Biol, 2011, 13, 1265-71. BI 2536 purchased from Selleck
Method cold-stable assay, Immunological methods
Cell Lines RPE1 cells
Concentrations 40 nM
Incubation Time 45 min
Results To examine whether B56-PP2A attenuates the signalling of kinetochore kinases other than Aurora B, we examined Plk1. Remarkably, wash-in of the Plk1 inhibitor BI2536 also restored K-fibres in B56-PP2A-siRNA cells.

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Western blot
Cell Lines NB TICs
Concentrations 10-100 nM
Incubation Time 16/24 h
Results The cyclin-dependent kinase inhibitor p21, a newly identified substrate of PLK1, also accumulated in BI 2536-treated NB TICs (Fig. C). Finally, PLK1 kinase activity was inhibited following treatment of NB TICs with BI 2536, as demonstrated by anti-PLK1 immunoprecipitiation followed by in vitro PLK1 kinase assay ( Fig. D)

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Trypan blue exclusion, Western blot
Cell Lines NB TICs
Concentrations 10/30/100 nmol/L
Incubation Time 24/48/72 h
Results We observed a significant difference in viable cell numbers in BI2536-treated samples, as compared with DMSO (vehicle)-treated cells, at 24 hours posttreatment. The difference became more pronounced with time, such that at 72 hours there were only approximately 20% viable cells following treatment with 10 nmol/L BI 2536 and approximately 2% to 5% viable cells following treatment with 30 and 100 nmol/L as compared with DMSO-treated cells(Fig. A). At 24 hours, BI 2536-treated cells gradually accumulated cleaved PARP, in contrast to DMSO-treated cells, suggesting induction of apoptosis ( Fig. B).

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5-25 mg/kg
Incubation Time 0-24 d
Results As shown in Figure A,tumor growth was significantly inhibited following administration of the third cycle of BI 2536 therapy. When mice were administered 25 mg/ kg weekly on 2 consecutive days for a total of only 2 cycles, tumor growth was inhibited after the second cycle ( Fig. B)

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Source Cancer Res, 2011, 71, 1385-1395. BI 2536 purchased from Selleck
Method Tumor growth assay
Cell Lines NOD/SCID mice
Concentrations 12.5 mg/kg
Incubation Time 0-60 d
Results We examined a combination of a low dose of BI 2536 (12.5 mg/kg) with a low dose of irinotecan (10 mg/kg), a topoisomerase inhibitor with demonstrated activity in phase II clinical trials in relapsed NB. Single-agent treatment with low-dose of either BI 2536 or irinotecan was comparably efficacious, resulting in significant growth inhibition, as compared with vehicle-treated animals.

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Source J Invest Dermatol, 2011, 131, 1886–1895. BI 2536 purchased from Selleck
Method MTT assay
Cell Lines M14 cell lines, WM-115 cell lines
Concentrations 1-20 nM
Incubation Time
Results Specific inhibition of Plk-1 using the commercially available inhibitor BI 2536 led to a dose- and time-dependent decrease in human melanoma cell viability.

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Source J Biol Chem, 2012, 287(21), 17088-99. BI 2536 purchased from Selleck
Method Cell death assay
Cell Lines HeLa cells
Concentrations 0 -120 nM
Incubation Time 72 h
Results In HeLa cells lacking GRK5, there was an~4.5-fold decrease in the EC50 of BI 2536-mediated cell death (control shRNA, 18.9 ?.2 nM; GRK5 shRNA, 4.1?.1 nM, n = 6, p < 0.05) (Fig. A). Similar to BI 2536, cells lacking GRK5 were ~4.5-fold more sensitive to GSK461364 compared with control cells (EC50 for control shRNA cells, 17.0 ?4.4 nM;EC50 for GRK5-shRNA cells, 3.8 ?0.7 nM, n = 4, p < 0.05).

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Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 0-10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

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Rating
Source J Biomol Screen, 2013, 18(1), 54-66. BI 2536 purchased from Selleck
Method 3D Tumor Growth Assay
Cell Lines PC-3M cells
Concentrations 10uM
Incubation Time 7 d
Results Reduction of colony size was observed for a number of established anticancer drugs, and IC 50 values for those reference compounds were determined based on the average area size of the cluster. IC 50 values were determined in two independent experiments and were quite reproducible.

文献中の引用 (51)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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