BEZ235 (NVP-BEZ235, Dactolisib) 化学構造
分子量: 469.55

高品質保証

文献中の引用(80)

カスタマーフィードバック(8)

Quality Control & MSDS

製品説明

  • Compare PI3K Inhibitors
    PI3K製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 BEZ235 (NVP-BEZ235, Dactolisib)は競争性的なPI3K、mTOR 阻害剤、 p110α, p110γ, p110δ と p110β を作用すると、 IC50 がぞれぞれ 4 nM, 5 nM, 7 nM と 75 nMになる.
ターゲット

p110α

p110γ

p110δ

p110β

ATR

IC50

4 nM

5 nM

7 nM

75 nM [1]

21 nM [8]

In vitro試験 BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
Trypanosoma brucei brucei NEXuZmJCdnSrbXnjdo9jcWGuIFHzd4F6 NXS1WVR7OThiaB?= NH:1bZdFVVOR MUnBcpRqfHK7cHHuc5NwdWGuIHHjeIl3cXS7IIfpeIghTUN3MDDv[kAxNjByMkWg{txO NYHmTXU3OjR6MEW5OFY>
MCF7 NIXIVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PkTVAvODFvMUCwJO69VQ>? M3PC[lQ5KGh? NVTtU2hiTE2VTx?= MmLkTWM2OD1yLkezJO69VQ>? Mmf5NlM5PzF7MES=
HCT116 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUKwMlAyNTFyMDFOwG0> NFPYUZY1QCCq MVLEUXNQ MoTLTWM2OD1zLkG2JO69VQ>? NWr3S2M2OjN6N{G5NFQ>
U87MG Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DLeFAvODFvMUCwJO69VQ>? M1Xq[FQ5KGh? MkG4SG1UVw>? MYTJR|UxRTFwM{Kg{txO MmPSNlM5PzF7MES=
HBC4 NGC0VVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzIU3dYOC5yMT2xNFAh|ryP MXG0PEBp M3frTmxw\yCJSUWwQU05NjZzIF2= MYOyNlM{PjJ2Nh?=
BSY1 NF7MU2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzOZlB1OC5yMT2xNFAh|ryP NVnCcGViPDhiaB?= MWPMc4chT0l3ME2tPE41QCCP M2TrXVIzOzN4MkS2
HBC5 Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLvNE4xOS1zMECg{txO M3;6e|Q5KGh? MWDMc4chT0l3ME2tO{45PyCP MlPQNlI{OzZ{NE[=
MCF7 M2rHWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M331c|AvODFvMUCwJO69VQ>? M{jtNFQ5KGh? MlLMUI9oKEeLNUC9MVgvOTZiTR?= MXuyNlM{PjJ2Nh?=
MDA-MB-231 M2n0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\qNE4xOS1zMECg{txO NUjVfHlHPDhiaB?= NV:3c294VG:pIFfJOVA:NThwMEmgUS=> M4\ac|IzOzN4MkS2
U251 NVjrV5ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYiwMlAyNTFyMDFOwG0> M1jjZ|Q5KGh? MX3Mc4chT0l3ME2tO{43PiCP NHzoflEzOjN|NkK0Oi=>
SF268 M2SyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVmwMlAyNTFyMDFOwG0> MUe0PEBp MkTwUI9oKEeLNUC9MVcvQTJiTR?= MmrXNlI{OzZ{NE[=
SF295 NUD3bZpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TyVlAvODFvMUCwJO69VQ>? NYLCeopbPDhiaB?= NFHGXoVNd2diR1m1NF0uQC5|MTDN M3fUVlIzOzN4MkS2
SF539 NHTJcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWwNE4xOS1zMECg{txO MkDUOFghcA>? MkL2UI9oKEeLNUC9MVgvPTliTR?= M1nxTVIzOzN4MkS2
SNB75 NIjHVHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\WTnJyOC5yMT2xNFAh|ryP NYnGTYJMPDhiaB?= NFiwfVJNd2diR1m1NF0uQC53ODDN NH3UO5IzOjN|NkK0Oi=>
SNB78 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jyWlAvODFvMUCwJO69VQ>? NFXIfWE1QCCq M4ry[mxw\yCJSUWwQU05NjZ3IF2= NF;uVnQzOjN|NkK0Oi=>
HCC2998 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzJbGExNjBzLUGwNEDPxE1? NEDwflI1QCCq M1TJV2xw\yCJSUWwQU05NjB3IF2= NFH5b|IzOjN|NkK0Oi=>
KM12 NVfPe4lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTYNHF3OC5yMT2xNFAh|ryP MWG0PEBp MULMc4chT0l3ME2tO{42PCCP M37Xd|IzOzN4MkS2
HT-29 NGW0ZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHOSXVYOC5yMT2xNFAh|ryP NWXYO3RRPDhiaB?= NWfJ[Zc{VG:pIFfJOVA:NTdwN{WgUS=> MXqyNlM{PjJ2Nh?=
HCT15 NXfNWpRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zkSFAvODFvMUCwJO69VQ>? NYDibGNYPDhiaB?= MU\Mc4chT0l3ME2tPE4xOyCP M2\UPFIzOzN4MkS2
HCT116 M2C0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:5boExNjBzLUGwNEDPxE1? MUC0PEBp NYrYPFE6VG:pIFfJOVA:NTdwNkGgUS=> NFzPc|czOjN|NkK0Oi=>
NCI-H23 MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\0clAvODFvMUCwJO69VQ>? MYW0PEBp NFW3NpRNd2diR1m1NF0uPy54NDDN NUmzU4JYOjJ|M{[yOFY>
NCI-H226 NHfFT|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfORlNPOC5yMT2xNFAh|ryP NVuycmZ4PDhiaB?= NXvqb|RVVG:pIFfJOVA:NThwNESgUS=> MmLENlI{OzZ{NE[=
NCI-H522 M3K3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG1dZYxNjBzLUGwNEDPxE1? MU[0PEBp NFu1NpNNd2diR1m1NF0uQC52NTDN MkHmNlI{OzZ{NE[=
NCI-H438 NH;m[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTyTVRtOC5yMT2xNFAh|ryP MnH2OFghcA>? MlvJUI9oKEeLNUC9MVgvOTFiTR?= M{nGdlIzOzN4MkS2
A549 NH60VYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzLfHcxNjBzLUGwNEDPxE1? M{\mOVQ5KGh? M13lXWxw\yCJSUWwQU05NjB5IF2= NFPMdHUzOjN|NkK0Oi=>
DMS273 MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K5TVAvODFvMUCwJO69VQ>? NYP3S25HPDhiaB?= MUXMc4chT0l3ME2tO{45OCCP MlHZNlI{OzZ{NE[=
DMS114 NH\RO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LpXVAvODFvMUCwJO69VQ>? NXXEU|B5PDhiaB?= M3LONGxw\yCJSUWwQU05NjN7IF2= NV7veodWOjJ|M{[yOFY>
LOXIMVI M2XFUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHQbIR[OC5yMT2xNFAh|ryP NGnPWI41QCCq MUnMc4chT0l3ME2tPE43PiCP M{Pyd|IzOzN4MkS2
OVCAR3 NFLBTI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDBNE4xOS1zMECg{txO M4\velQ5KGh? NXfNOJRyVG:pIFfJOVA:NThwMUegUS=> NFXVco0zOjN|NkK0Oi=>
OVCAR4 M1nJ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnUOHFrOC5yMT2xNFAh|ryP M{CwUVQ5KGh? M1PGcWxw\yCJSUWwQU05NjV6IF2= NUCzWG1ROjJ|M{[yOFY>
OVCAR5 NHnIb4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zQOFAvODFvMUCwJO69VQ>? NFO3fFE1QCCq MWLMc4chT0l3ME2tO{42PyCP NFTTeJczOjN|NkK0Oi=>
OVCAR8 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nyRVAvODFvMUCwJO69VQ>? M{XnVVQ5KGh? MXPMc4chT0l3ME2tO{45PCCP NXXCO|JROjJ|M{[yOFY>
SKOV3 NYTCXoxET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:wMlAyNTFyMDFOwG0> NV7SRWh7PDhiaB?= M1TEcWxw\yCJSUWwQU05NjRzIF2= MlX1NlI{OzZ{NE[=
RXF631L MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PxclAvODFvMUCwJO69VQ>? NEjOTYE1QCCq MlHTUI9oKEeLNUC9MVgvOjFiTR?= NIDk[FUzOjN|NkK0Oi=>
ACHN M1n1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\oNE4xOS1zMECg{txO M3z5UFQ5KGh? NGnjWGxNd2diR1m1NF0uPy57NTDN NHLmR5EzOjN|NkK0Oi=>
St-4 NF\ZbVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\EelAvODFvMUCwJO69VQ>? NHHFb4U1QCCq NXXZXI9zVG:pIFfJOVA:NTdwNEegUS=> NYTRNFg2OjJ|M{[yOFY>
MKN1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\SbGdQOC5yMT2xNFAh|ryP NEDWXYk1QCCq Ml\CUI9oKEeLNUC9MVgvPDFiTR?= NVzCUmlCOjJ|M{[yOFY>
MKN7 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV2wMlAyNTFyMDFOwG0> NH;4b5k1QCCq NIjZ[GNNd2diR1m1NF0uPy54ODDN MlnhNlI{OzZ{NE[=
MKN28 NHnERWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfEVVFIOC5yMT2xNFAh|ryP MVW0PEBp M2[xO2xw\yCJSUWwQU04NjB5IF2= NWKzSWJ3OjJ|M{[yOFY>
MKN45 NEDqRVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\sbFAvODFvMUCwJO69VQ>? NFi1Tm01QCCq NV3RUmRIVG:pIFfJOVA:NThwM{SgUS=> MX[yNlM{PjJ2Nh?=
MKN74 M4\QeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fNV|AvODFvMUCwJO69VQ>? MX[0PEBp NWDMT5JmVG:pIFfJOVA:NTdwNEKgUS=> NX2wRXB3OjJ|M{[yOFY>
DU145 NILufGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfwZ5IxNjBzLUGwNEDPxE1? NFPUTVU1QCCq NFHtOYFNd2diR1m1NF0uQC5zNjDN NYLFV5hCOjJ|M{[yOFY>
PC3 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HFOFAvODFvMUCwJO69VQ>? MXK0PEBp MonpUI9oKEeLNUC9MVgvPjZiTR?= MYGyNlM{PjJ2Nh?=
Trypanosoma brucei brucei NGTkeHNHfW6ldHnvckBCe3OjeR?= NYDZOmxHOjByIH7N MUCxNkBp NYj0[o5TTE2VTx?= M4TZ[2Rm[3KnYYPlJIlvKHCqb4PwbI91cWS7bDDpco9{cXSxbDDwbI9{eGijdHWgcIV3\Wx? MY[yOFgxPTl2Nh?=
Trypanosoma brucei brucei M1mzWGZ2dmO2aX;uJGF{e2G7 NVzLZndbOThiaB?= NGXmU|lFVVOR MXfJcohq[mm2aX;uJI9nKHKnY3XweI9zNW2nZHnheIVlKGWwZH;jfZRwe2m|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHS{YX7z[oVzemmwIIXweIFs\Q>? NWfoRVBGOjR6MEW5OFY>
Trypanosoma brucei brucei MX;GeY5kfGmxbjDBd5NigQ>? NYPudmppOjByIH7N NIK3T2oyOiCq MYjEUXNQ MofnSYZn\WO2IH;uJJNxcGmwZ3;tfYxmcW5ibHX2[Yw> NFTKe5AzPDhyNUm0Oi=>
Trypanosoma brucei brucei MYLGeY5kfGmxbjDBd5NigQ>? MnrqNlAxKG6P NVKzVGJQOTJiaB?= MlzQSG1UVw>? MVfF[oZm[3Rib36gdIhwe3CqYYTp[Jlt[2ixbHnu[UBt\X[nbB?= M{HtVVI1QDB3OUS2
UM-UC-3 NH7nSFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTlTWM2OD1|MUWgdG0> MVHTRW5ITVJ?
SBC-1 M{j4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjJO|NNUUN3ME23OFIheE1? NUXCZmxVW0GQR1XS
MKN1 NFrudllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\vSWdKSzVyPUKuPEBvVQ>? NGf6[JZUSU6JRWK=
NCI-H720 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTNwNUegcm0> MmTyV2FPT0WU
BFTC-909 M1PKc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETvTmtKSzVyPUOuO|Ehdk1? NIDEdnlUSU6JRWK=
BPH-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTRwN{[gcm0> M2XDRnNCVkeHUh?=
PC-3 NWnzdHdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HtSmlEPTB;NT6wPUBvVQ>? NH3UWHBUSU6JRWK=
AN3-CA M4rxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjITWM2OD13LkW2JI5O MnfEV2FPT0WU
HN M{fxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTVwOU[gcm0> NEDyWGJUSU6JRWK=
HCC2218 M2rvSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWO1[IN[UUN3ME22MlYyKG6P M2PGfHNCVkeHUh?=
KP-4 M4jxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr2TWM2OD15IH7N M3fEO3NCVkeHUh?=
LU-139 MoizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTdwN{egcm0> NWT0UJJbW0GQR1XS
ETK-1 MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrVUGhUUUN3ME23Mlg5KG6P Ml;mV2FPT0WU
Ramos-2G6-4C10 M3flWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn23TWM2OD16LkS5JI5O M2X4OnNCVkeHUh?=
MHH-PREB-1 MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTlwMUKgcm0> M4G1RXNCVkeHUh?=
DU-4475 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYiyNYlsUUN3ME25MlQ1KG6P NHzGVoNUSU6JRWK=
NCI-H1666 M{\TdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTlwN{Ggcm0> NV7v[VdKW0GQR1XS
CAMA-1 NHnkTWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzmWIZKSzVyPUmuPEBvVQ>? MXTTRW5ITVJ?
TYK-nu MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn0N2FKSzVyPUmuPVQhdk1? MWnTRW5ITVJ?
MFE-280 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Pl[mlEPTB;OT65PUBvVQ>? MoXVV2FPT0WU
A549 NVHudGhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fjSGlEPTB;MUCuNVQhdk1? Mlm5V2FPT0WU
769-P NFzmcVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoWwTWM2OD1zMD60OEBvVQ>? NI\pUJZUSU6JRWK=
L-363 M2fkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTFyLk[5JI5O MV3TRW5ITVJ?
ES8 MmKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTUT|hKSzVyPUGwMlkhdk1? MlW3V2FPT0WU
PA-1 NGD3T4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzKTWM2OD1zMT64NkBvVQ>? NGXwSGlUSU6JRWK=
Mewo MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDSVnJKSzVyPUGxMlk6KG6P NXPpVHFlW0GQR1XS
HSC-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTF{LkKxJI5O NITRWlVUSU6JRWK=
H4 M3HaO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTF{Lk[3JI5O NHHNOVNUSU6JRWK=
BB65-RCC NXTC[JdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPpRm1KSzVyPUGyMlczKG6P MVnTRW5ITVJ?
NCI-H1793 M3PnWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O1UGlEPTB;MUKuPFIhdk1? MYHTRW5ITVJ?
KARPAS-45 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K4ZWlEPTB;MUOuOVEhdk1? M3TEcnNCVkeHUh?=
GCT MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M372d2lEPTB;MUOuOlghdk1? MkiyV2FPT0WU
EoL-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLQTWM2OD1zMz65N{BvVQ>? MYnTRW5ITVJ?
LB2241-RCC M2jIZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPWTWM2OD1zND6wNUBvVQ>? NW\wWnFLW0GQR1XS
ES5 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjTboZkUUN3ME2xOE44PCCwTR?= MWPTRW5ITVJ?
LOXIMVI NYnsZ|lTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHYTWM2OD1zND65PUBvVQ>? MneyV2FPT0WU
COR-L105 NEfwR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF3LkC0JI5O Mlj6V2FPT0WU
P12-ICHIKAWA Mmi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnBNmlKSzVyPUG1MlEhdk1? NX;sOJZEW0GQR1XS
CHL-1 M17BSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTF3LkS1JI5O Ml\FV2FPT0WU
VMRC-RCZ MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTF3Lk[zJI5O MYXTRW5ITVJ?
HH MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTuZoN{UUN3ME2xOU44KG6P Ml\qV2FPT0WU
NUGC-3 M4\Sfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHoOHpKSzVyPUG2MlM1KG6P M4\sNXNCVkeHUh?=
EGI-1 NG\JfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XFTGlEPTB;MU[uOFMhdk1? NFTKWI9USU6JRWK=
OS-RC-2 MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHyxSJRKSzVyPUG2MlQ4KG6P NFKwO|BUSU6JRWK=
MOLT-16 NVvVRZZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTF5LkG1JI5O MlryV2FPT0WU
NCI-H209 MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF5LkK5JI5O MnLHV2FPT0WU
697 NYWxPJM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zuTWlEPTB;MUeuOFMhdk1? NFfaOXhUSU6JRWK=
D-56MG M3f6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3yxPWlEPTB;MUeuOlkhdk1? NUjjNHREW0GQR1XS
VA-ES-BJ MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf4cHVsUUN3ME2xO{45OyCwTR?= NIrMfVNUSU6JRWK=
EW-16 MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF6LkC0JI5O NUS0fVdVW0GQR1XS
HGC-27 NFPyN29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXLTWM2OD1zOD6wOkBvVQ>? NXjae5hIW0GQR1XS
ES7 NX[2Z2ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fubmlEPTB;MUiuNFkhdk1? MXjTRW5ITVJ?
HuH-7 Mke3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTF6LkSgcm0> NXX1OldiW0GQR1XS
BCPAP NW\ZblhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS2W4M4UUN3ME2xPE43PSCwTR?= M{TjcXNCVkeHUh?=
SW1710 M3XmU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPEdWtKSzVyPUG4MlczKG6P MYjTRW5ITVJ?
IST-MEL1 Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vJc2lEPTB;MUiuO|chdk1? NXTCeHBJW0GQR1XS
SF295 NXnBNmJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2G1[2lEPTB;MUiuPVMhdk1? M1exTXNCVkeHUh?=
RPMI-7951 NGS4OlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXiXnU6UUN3ME2xPU4zQCCwTR?= NFfZUWxUSU6JRWK=
SF126 NFfCZnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrJ[JNxUUN3ME2xPU41OSCwTR?= Mo\uV2FPT0WU
GAMG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrPTWM2OD1zOT60PEBvVQ>? M3zLUnNCVkeHUh?=
KNS-81-FD NUXUNo9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTF7LkW0JI5O NFTVTVJUSU6JRWK=
RT-112 MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\K[XYxUUN3ME2xPU43PiCwTR?= M1\xV3NCVkeHUh?=
DEL NFjGc29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXkTWM2OD1{MD60PUBvVQ>? MYXTRW5ITVJ?
CGTH-W-1 NHO3VZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHvTWM2OD1{MD62N{BvVQ>? M3fn[XNCVkeHUh?=
HOS NVPkc29XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETtb5VKSzVyPUKxMlA3KG6P MUDTRW5ITVJ?
ES4 NIPS[2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTsOlFKSzVyPUKxMlA5KG6P MoLDV2FPT0WU
RXF393 NHfPdGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHf2T4ZKSzVyPUKxMlQ2KG6P NFv3eIFUSU6JRWK=
NCI-H2030 NHLVdWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJzLkWyJI5O M{XFW3NCVkeHUh?=
YH-13 NWfpU5hZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHqTWM2OD1{MT64PEBvVQ>? M2Hxd3NCVkeHUh?=
HT-1080 M4jTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrI[20zUUN3ME2yNU46OyCwTR?= NEnUZlRUSU6JRWK=
NCI-SNU-1 NWm1fmJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJzLkm1JI5O M2LuTnNCVkeHUh?=
G-402 M4D6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vJV2lEPTB;MkKuNVYhdk1? NXK5SotoW0GQR1XS
786-0 NWT3bo9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXBU|FmUUN3ME2yNk4zQSCwTR?= M{LWfHNCVkeHUh?=
ME-180 M1m3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHQTWM2OD1{Mj60N{BvVQ>? M1TOXHNCVkeHUh?=
NB69 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DIZWlEPTB;MkKuOVMhdk1? MnfkV2FPT0WU
J-RT3-T3-5 M37Pfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M32wVmlEPTB;MkKuPVYhdk1? M4\4SHNCVkeHUh?=
TGBC1TKB MmrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETxeVFKSzVyPUKzMlA2KG6P MUHTRW5ITVJ?
SW780 NXXZWZl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJ|LkGzJI5O MVPTRW5ITVJ?
MG-63 MnPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJ|LkS1JI5O NWXMNnVlW0GQR1XS
BV-173 M3TSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LQWGlEPTB;MkOuPFchdk1? NWLRbZl[W0GQR1XS
CAL-51 M4jHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH2ycoxKSzVyPUKzMlg6KG6P M4DiVnNCVkeHUh?=
A375 M1njOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom3TWM2OD1{Mz65N{BvVQ>? NX3uZ|ZtW0GQR1XS
MEL-HO MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ2LkC0JI5O MmT1V2FPT0WU
EFO-27 NIDZOVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf1OnFIUUN3ME2yOE4{OyCwTR?= NXnTO|Q1W0GQR1XS
Hs-578-T M{LKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjPXWVHUUN3ME2yOE42QCCwTR?= MXfTRW5ITVJ?
NBsusSR Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XEV2lEPTB;MkSuOkBvVQ>? NWLYSotwW0GQR1XS
CTB-1 NWfad4NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTJ2Lk[3JI5O NX35c486W0GQR1XS
FTC-133 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzsPHpjUUN3ME2yOU4yKG6P M{LhXXNCVkeHUh?=
MOLT-4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y1XmlEPTB;MkWuNVIhdk1? M3\D[HNCVkeHUh?=
HO-1-N-1 M{LQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7ZTWM2OD1{NT6xOUBvVQ>? M1vaSXNCVkeHUh?=
ES3 M4\ydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1faOmlEPTB;MkWuNlIhdk1? NFXzbIJUSU6JRWK=
TI-73 NIizbWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LWOGlEPTB;MkWuNlghdk1? NHnoOIpUSU6JRWK=
MPP-89 NV;pZoxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS1eIFCUUN3ME2yOU4{OiCwTR?= M2ThNHNCVkeHUh?=
KYSE-150 NUjjRZV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfBRYFKSzVyPUK1Mlg6KG6P MoDiV2FPT0WU
LXF-289 MkP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrvNHpKSzVyPUK2MlA1KG6P NGXJeHFUSU6JRWK=
SK-LU-1 MlrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjXTWM2OD1{Nj6xO{BvVQ>? NGPKUXNUSU6JRWK=
HOP-92 M2GwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJ4LkS4JI5O MkftV2FPT0WU
HuO9 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj0TWM2OD1{Nj63OkBvVQ>? MWrTRW5ITVJ?
SW962 NVHjXJM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLNS2R{UUN3ME2yOk44PiCwTR?= Ml3BV2FPT0WU
RS4-11 NWDuXoV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q4TmlEPTB;Mk[uPVEhdk1? NXXzOpM3W0GQR1XS
NCI-H292 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELVNIpKSzVyPUK3JI5O MUjTRW5ITVJ?
DB MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\rdWtKSzVyPUK3MlM3KG6P MV;TRW5ITVJ?
SW1088 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILxe21KSzVyPUK4MlI6KG6P NH;BPWdUSU6JRWK=
A204 NVjwe5ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLDTWM2OD1{OD60O{BvVQ>? NVyxVVE1W0GQR1XS
A3-KAW MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrKUpNmUUN3ME2yPE43PCCwTR?= NVnaXpNnW0GQR1XS
MV-4-11 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ6Lkegcm0> MXzTRW5ITVJ?
ES1 M{L0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i4R2lEPTB;MkiuPFQhdk1? M2S5SXNCVkeHUh?=
ONS-76 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfSdG1KSzVyPUK5MlA2KG6P M3XZdnNCVkeHUh?=
D-263MG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLCd3dKSzVyPUK5MlM2KG6P NE\FSnVUSU6JRWK=
U-2-OS NGD6c4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\zRVJKSzVyPUK5MlUhdk1? MUfTRW5ITVJ?
T98G MlfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJ7Lki4JI5O M3;qUXNCVkeHUh?=
GI-ME-N MkHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrRVmRGUUN3ME2yPU46OSCwTR?= MnjpV2FPT0WU
BHT-101 NYXjNVJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKzW4pKSzVyPUOwMlA2KG6P M3HkR3NCVkeHUh?=
NOS-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\QTWM2OD1|MD6xNkBvVQ>? NWjad5lSW0GQR1XS
AsPC-1 MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jDT2lEPTB;M{CuNkBvVQ>? MXzTRW5ITVJ?
QIMR-WIL MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnafW91UUN3ME2zNE43KG6P M3;ZNXNCVkeHUh?=
JVM-3 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW0WHFrUUN3ME2zNE45OyCwTR?= NGXz[5ZUSU6JRWK=
KU-19-19 MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1H0TmlEPTB;M{GuNVMhdk1? NV7xW243W0GQR1XS
OVCAR-8 Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTNzLkK2JI5O MX3TRW5ITVJ?
BEN NFPzfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn1TWM2OD1|MT62N{BvVQ>? MY\TRW5ITVJ?
BE-13 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvhTWM2OD1|MT64NkBvVQ>? NVjKNXUzW0GQR1XS
EW-18 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNzLki2JI5O NITwbJVUSU6JRWK=
ECC10 NWnXWJF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYT6cnlKUUN3ME2zNU46PSCwTR?= NF\0cXhUSU6JRWK=
CTV-1 M1zMVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzpTWM2OD1|Mj64NkBvVQ>? MmjlV2FPT0WU
COLO-800 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPLS4xKSzVyPUOyMlkzKG6P NF\yW3FUSU6JRWK=
A2058 M4XCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLwTWM2OD1|Mz6yOUBvVQ>? NWHvNnVrW0GQR1XS
VM-CUB-1 M1[wUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEL1W4FKSzVyPUOzMlQ{KG6P MUnTRW5ITVJ?
Ca9-22 NWXjS5FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXKTWM2OD1|Mz61OUBvVQ>? NYf4ZlRtW0GQR1XS
COLO-684 NEXaeHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\HXlhMUUN3ME2zN{42QCCwTR?= MlP3V2FPT0WU
RPMI-8226 NGPnPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH0TWM2OD1|Mz64NkBvVQ>? Ml7xV2FPT0WU
SK-NEP-1 NFvuU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDXTWM2OD1|ND6xOUBvVQ>? M2S4NHNCVkeHUh?=
Becker NGG2S3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlyxTWM2OD1|ND6yNUBvVQ>? NFTsfnJUSU6JRWK=
NCI-H28 NXrmXYdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vjcGlEPTB;M{SuOFQhdk1? MUDTRW5ITVJ?
CAL-120 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fMe2lEPTB;M{SuO|Ihdk1? MnGxV2FPT0WU
MDA-MB-157 NF6zeZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TiemlEPTB;M{WuOFEhdk1? NUL5fm9NW0GQR1XS
OVCAR-5 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnMZXk4UUN3ME2zOU41PyCwTR?= NXnLSoxyW0GQR1XS
LAMA-84 M4LF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1u5e2lEPTB;M{WuPFchdk1? M{jjdHNCVkeHUh?=
CAKI-1 M4n6PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X1cGlEPTB;M{[uOFMhdk1? M3y5O3NCVkeHUh?=
Daoy NWT3V2ZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfUOVJTUUN3ME2zOk44KG6P M{fr[3NCVkeHUh?=
CAL-62 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXPTWM2OD1|Nj64OkBvVQ>? M4jmWXNCVkeHUh?=
8-MG-BA MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXWwTXBjUUN3ME2zO{4zPSCwTR?= MV;TRW5ITVJ?
8505C MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\DcpdKSzVyPUO3MlUyKG6P NYrpS29ZW0GQR1XS
LNCaP-Clone-FGC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTN5LkW5JI5O M33SNHNCVkeHUh?=
CAL-39 NV\HU2dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLjenJKSzVyPUO3Mlkhdk1? NWC3PXVUW0GQR1XS
MN-60 NW\ObFdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTN5Lkm2JI5O MUTTRW5ITVJ?
RKO NGLnb4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPGTHB2UUN3ME2zPE4{OyCwTR?= MlHHV2FPT0WU
U251 NEHGS2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nKN2lEPTB;M{iuOFMhdk1? MVnTRW5ITVJ?
SJSA-1 NFzkcHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP2TWM2OD1|OD61OEBvVQ>? MnX2V2FPT0WU
CAL-12T MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTN6Lk[gcm0> MnLSV2FPT0WU
HCC1419 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWm4NWdWUUN3ME2zPE44OSCwTR?= NWj3Vm5PW0GQR1XS
CO-314 NITPNJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH4PIRKSzVyPUO4Mlc1KG6P MmnEV2FPT0WU
LB1047-RCC M1;wUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTje4VvUUN3ME2zPE45OSCwTR?= Mmm2V2FPT0WU
A101D NELyNI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DTZmlEPTB;M{iuPVchdk1? MoTPV2FPT0WU
MDA-MB-175-VII NHy0c5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfkbGtKSzVyPUO5MlUyKG6P MUXTRW5ITVJ?
MZ2-MEL Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTN7Lk[2JI5O NWj6N2FDW0GQR1XS
NB5 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnBTWM2OD12MD62OEBvVQ>? MnTBV2FPT0WU
G-401 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrpU29nUUN3ME20NE45OiCwTR?= MWLTRW5ITVJ?
HT NWf4TnMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDQNoZKSzVyPUSxMlAzKG6P MlvZV2FPT0WU
8305C MnPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXuyOmFMUUN3ME20NU45PyCwTR?= MUTTRW5ITVJ?
BHY NFrXTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH6yZ2pKSzVyPUSyMlczKG6P M4fPUnNCVkeHUh?=
NTERA-S-cl-D1 MoTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTR|IH7N NFrsb|ZUSU6JRWK=
T-24 NUnTSoxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTR|LkizJI5O M{jJbHNCVkeHUh?=
EPLC-272H NGi0O4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[zSJJ6UUN3ME20OE4{QSCwTR?= MXfTRW5ITVJ?
PSN1 M3fHe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXlWI5qUUN3ME20OE41KG6P NG\WbGdUSU6JRWK=
NCI-H2452 M1jWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrXflZKSzVyPUS0MlU5KG6P NVfm[XN7W0GQR1XS
KS-1 Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTR2Lk[2JI5O M2P4fXNCVkeHUh?=
HD-MY-Z MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7keGhmUUN3ME20OE46OiCwTR?= MlK0V2FPT0WU
KNS-62 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq5cZJ4UUN3ME20OU4{QCCwTR?= NH7iUXFUSU6JRWK=
NOMO-1 M1q4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTR3Lki3JI5O NEDaTZZUSU6JRWK=
SK-HEP-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTR4LkC0JI5O NUPIO5VOW0GQR1XS
IGR-1 NFzLUHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq4UYtKSzVyPUS2MlE{KG6P M4i5SnNCVkeHUh?=
KYSE-180 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L1bWlEPTB;NE[uNVchdk1? NILJb45USU6JRWK=
EW-22 NETWSnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nOeGlEPTB;NE[uNkBvVQ>? M4DpSXNCVkeHUh?=
NCI-H1355 Ml;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPjTWdQUUN3ME20Ok4{PCCwTR?= M3WzbHNCVkeHUh?=
DOHH-2 NVvuOoZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrLUGY5UUN3ME20Ok4{PyCwTR?= M2TieXNCVkeHUh?=
A4-Fuk M3LHemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj3bGJKSzVyPUS2MlUzKG6P NETBXpRUSU6JRWK=
PC-14 M4jnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PSU2lEPTB;NE[uOVchdk1? NITXeJVUSU6JRWK=
TE-5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTR4Lki0JI5O MVTTRW5ITVJ?
LB996-RCC M{XkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2roRWlEPTB;NEeuNVkhdk1? NFXiRnNUSU6JRWK=
NCI-H1623 Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDQWXNlUUN3ME20O{44PiCwTR?= NHvQUlVUSU6JRWK=
NCI-H1155 M2W0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPE[GM4UUN3ME20PE4{OiCwTR?= M1j2WXNCVkeHUh?=
LoVo NGfrdI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qyN2lEPTB;NEiuOEBvVQ>? NX\reZZVW0GQR1XS
MCF7 M1T2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7ITWM2OD12OD61PEBvVQ>? MVnTRW5ITVJ?
AGS NV\GR|RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17HeWlEPTB;NEiuO|chdk1? M3q2bHNCVkeHUh?=
PFSK-1 NYLlXYJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfxR2xwUUN3ME20PU4xPiCwTR?= MV7TRW5ITVJ?
22RV1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfDeG9QUUN3ME20PU4xQSCwTR?= MojxV2FPT0WU
COR-L23 MkTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrheHhKSzVyPUS5MlE3KG6P M1T0fHNCVkeHUh?=
D-283MED NWH6eY85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG0TWM2OD12OT62NUBvVQ>? MWjTRW5ITVJ?
SW982 NXHvPG5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\xTWM2OD12OT65NUBvVQ>? NFzFNW1USU6JRWK=
SW620 MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnniTWM2OD13MD6zOkBvVQ>? NWjEcXI1W0GQR1XS
KYSE-140 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XwTGlEPTB;NUCuOVUhdk1? M3vzTnNCVkeHUh?=
GCIY Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLteWxKSzVyPUWwMlY4KG6P NW\YemplW0GQR1XS
MHH-ESS-1 NYjYUW5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn3UmVkUUN3ME21NU46PSCwTR?= NXznbHI1W0GQR1XS
D-423MG MmDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H4XGlEPTB;NUKuNFghdk1? M3nmfXNCVkeHUh?=
SF539 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfZNYJKSzVyPUWyMlM2KG6P MkHaV2FPT0WU
RPMI-2650 NF3XNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHkWnNKSzVyPUWyMlY6KG6P NHroe45USU6JRWK=
GR-ST NF3oTlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDBTWM2OD13Mj64O{BvVQ>? Mke5V2FPT0WU
YKG-1 MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTNVllYUUN3ME21N{BvVQ>? NFjsTmxUSU6JRWK=
SK-MES-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjQe5VXUUN3ME21N{4zPiCwTR?= NG\qb|FUSU6JRWK=
HLE NVnFVXk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInhdoZKSzVyPUWzMlQ4KG6P MnLKV2FPT0WU
RVH-421 NUTGTpNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H3cmlEPTB;NUOuOlchdk1? NXjpO|VUW0GQR1XS
C32 NIPFRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTV|LkizJI5O M{TET3NCVkeHUh?=
GB-1 M1HDbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:3TWM2OD13ND6yJI5O NVzweHFlW0GQR1XS
SNB75 M2\xZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHuUmlPUUN3ME21OE4zPiCwTR?= NHO5TY1USU6JRWK=
EM-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjrT3BKSzVyPUW0MlQhdk1? MVTTRW5ITVJ?
RH-1 MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nvbmlEPTB;NUSuO{BvVQ>? MoTzV2FPT0WU
NKM-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTV2LkixJI5O NF74[nlUSU6JRWK=
NCI-H2405 NVvBNnY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;uTWM2OD13ND64PEBvVQ>? MVPTRW5ITVJ?
KYSE-450 MmnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL4RXlPUUN3ME21OU4yPiCwTR?= NG[4R3pUSU6JRWK=
A704 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYKyWYhlUUN3ME21OU42QSCwTR?= MmLxV2FPT0WU
HAL-01 NGDEWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLOPWpKSzVyPUW1Mlg{KG6P MU\TRW5ITVJ?
TE-11 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTV3Lkm5JI5O M1\YZXNCVkeHUh?=
DOK M{nx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTV4LkCyJI5O NF[xRmtUSU6JRWK=
KY821 NYriTopyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX1RnZPUUN3ME21Ok4zKG6P NH3rTGlUSU6JRWK=
KGN MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj3WWxKSzVyPUW2MlMzKG6P MWDTRW5ITVJ?
MC116 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\rSINKSzVyPUW3Mlghdk1? M{GzUXNCVkeHUh?=
PANC-08-13 NFuzRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\KZWx7UUN3ME21PE4xOSCwTR?= NXzBXndMW0GQR1XS
KE-37 NHWxS5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrFU5VKSzVyPUW4Mlc4KG6P NWfHdW5xW0GQR1XS
KYSE-410 NWLpcVU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjzNoFmUUN3ME21PU41PyCwTR?= MnrZV2FPT0WU
RO82-W-1 NVrJWpVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW4TWM2OD13OT65JI5O MoPYV2FPT0WU
M14 NFnYbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13ndGlEPTB;NkCuNFQhdk1? MkKyV2FPT0WU
GI-1 MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT1PJVLUUN3ME22NE4{KG6P NGr6ToRUSU6JRWK=
ML-2 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrCflRKSzVyPU[wMlYzKG6P MWTTRW5ITVJ?
BFTC-905 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i4RmlEPTB;NkCuOlUhdk1? NGDC[nhUSU6JRWK=
DMS-273 M1LnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LzVmlEPTB;NkCuPFchdk1? NFHMOZNUSU6JRWK=
MDA-MB-361 MkDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTZzIH7N NXqxXZI5W0GQR1XS
MSTO-211H NYrMbFhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrXTWM2OD14Mz61NUBvVQ>? MYDTRW5ITVJ?
MEG-01 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTLTWM2OD14Mz61NkBvVQ>? NHfoPG1USU6JRWK=
M059J MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL4TWM2OD14Mz61PEBvVQ>? M4jJR3NCVkeHUh?=
LN-405 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[zUIdWUUN3ME22N{45PSCwTR?= MY\TRW5ITVJ?
NCI-H1581 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXNRlBlUUN3ME22OE4xOyCwTR?= M3HyXHNCVkeHUh?=
TCCSUP NHrwNFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTZ2LkWzJI5O MX7TRW5ITVJ?
SW872 NUPpOmh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjaTWM2OD14ND61O{BvVQ>? MV7TRW5ITVJ?
KYSE-510 Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHzRohKSzVyPU[1Mlc2KG6P Mn[wV2FPT0WU
NCI-H1792 Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDFUZdKSzVyPU[2MlE2KG6P NW\iUlJrW0GQR1XS
SW13 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\6WWlEPTB;Nk[uOUBvVQ>? M3uyPXNCVkeHUh?=
TE-8 NVPDWVdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnIOlFKSzVyPU[2MlUzKG6P NIn4ZZpUSU6JRWK=
SCH MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInLU5NKSzVyPU[3MlEhdk1? MWTTRW5ITVJ?
NEC8 Mn;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTZ5LkK0JI5O NUDZ[lZlW0GQR1XS
HuO-3N1 NHK5cGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTZ5LkOxJI5O M3PZSnNCVkeHUh?=
EFM-19 NHrwNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jpZ2lEPTB;NkeuOUBvVQ>? NEnYbYRUSU6JRWK=
HEC-1 NXewN2RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3qW2dKSzVyPU[3MlUzKG6P MWTTRW5ITVJ?
T47D NFfmXVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTZ5Lki3JI5O NWDqW5BuW0GQR1XS
SNU-423 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTZ5Lkm4JI5O Mkm0V2FPT0WU
WM-115 NIGzeFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTZ6LkG0JI5O M3PkR3NCVkeHUh?=
CaR-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHxdYk5UUN3ME22PE4zPSCwTR?= MWnTRW5ITVJ?
KU812 Mlm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfFUnlKSzVyPU[4MlY6KG6P NEXjeJZUSU6JRWK=
AM-38 M{LieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvKTWM2OD14OT6zNUBvVQ>? M{\1WXNCVkeHUh?=
KOSC-2 NI\VenJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTZ7Lkm3JI5O M2TR[3NCVkeHUh?=
MC-IXC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXyZpk2UUN3ME23NE4xQCCwTR?= NVTSc3JzW0GQR1XS
SCC-4 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i4NWlEPTB;N{GuN|ghdk1? MlTwV2FPT0WU
Calu-3 M4Xte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrHRoVKSzVyPUexMlk5KG6P M2nkZXNCVkeHUh?=
RPMI-8866 Mn;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDU[GVKSzVyPUeyMlgzKG6P Moj5V2FPT0WU
OVCAR-4 MoDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PqZmlEPTB;N{OuN|Yhdk1? M2TqbXNCVkeHUh?=
OAW-42 NFXaSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTd|LkO5JI5O M3T4OXNCVkeHUh?=
ATN-1 NITtO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXXZYtKSzVyPUezMlg4KG6P NGrTUnRUSU6JRWK=
CHP-212 M1;GeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXyTWM2OD15ND65OUBvVQ>? MX;TRW5ITVJ?
C2BBe1 NFj0[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTd3LkCzJI5O MnfhV2FPT0WU
A498 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTlTmN[UUN3ME23OU4yPSCwTR?= M2\kdHNCVkeHUh?=
SH-4 NEDDNXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfW[XVWUUN3ME23OU4zOSCwTR?= NHfxVFdUSU6JRWK=
SNU-449 NX\2U3l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTd3Lke5JI5O Ml:zV2FPT0WU
RD MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTd3Lki2JI5O MWfTRW5ITVJ?
PANC-03-27 NHLJNmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\ITWM2OD15Nj6yOUBvVQ>? NGHKU3lUSU6JRWK=
S-117 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTd4LkK3JI5O NYW2[nQ3W0GQR1XS
SK-MEL-2 M4HSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTd4Lke1JI5O NILid29USU6JRWK=
LK-2 NUnzZYl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzRTWM2OD15Nz6wOUBvVQ>? MUTTRW5ITVJ?
CP50-MEL-B NVvxT|ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3SyWmlEPTB;N{euOEBvVQ>? Mn7HV2FPT0WU
647-V NFmyPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPIXXpKSzVyPUe4MlA4KG6P M3XDVXNCVkeHUh?=
LU-134-A NE\DbIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe3OWpNUUN3ME23PU4xOyCwTR?= MYjTRW5ITVJ?
5637 NFXEWYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HjNWlEPTB;N{muNlMhdk1? NYHMbnoxW0GQR1XS
NCI-H1437 M2W5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDuTWM2OD16MD61JI5O M13iUXNCVkeHUh?=
NCI-H460 NF\HNmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\DfZV4UUN3ME24NU4zOyCwTR?= NXXRenhkW0GQR1XS
BxPC-3 MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf5PFJKSzVyPUixMlQ3KG6P M4flS3NCVkeHUh?=
CAN Mn7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nEXGlEPTB;OEGuPFQhdk1? M3TKV3NCVkeHUh?=
KINGS-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTh{LkOyJI5O NI\JS3RUSU6JRWK=
OCUB-M MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHKNFNKSzVyPUiyMlQyKG6P NGHn[ItUSU6JRWK=
KALS-1 MlvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zFSWlEPTB;OEKuOVQhdk1? M1;STHNCVkeHUh?=
OCI-AML2 NV2xW45oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHzTWM2OD16Mj62NUBvVQ>? NGHzRm1USU6JRWK=
A253 NYjJXZVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrJUVFHUUN3ME24Nk43PSCwTR?= NGTvT45USU6JRWK=
LCLC-97TM1 M3r6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTh{Lki2JI5O MXPTRW5ITVJ?
NCI-H520 NIOzXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTh|LkC2JI5O MXzTRW5ITVJ?
P30-OHK NYjF[FdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi4[pZKSzVyPUizMlUhdk1? M4fM[3NCVkeHUh?=
SBC-5 NF\KNXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTh|LkWyJI5O M{DTRXNCVkeHUh?=
HCE-T MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\6TWM2OD16Mz63OEBvVQ>? M4nv[XNCVkeHUh?=
JEG-3 M33CT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17UfGlEPTB;OESuNUBvVQ>? M3TvXnNCVkeHUh?=
KG-1 NFjvd|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTvVHBKSzVyPUi0MlI1KG6P NGjXVWFUSU6JRWK=
MIA-PaCa-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLwXnZiUUN3ME24OE42PCCwTR?= M{jmT3NCVkeHUh?=
CAL-33 M1rN[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\wOWlEPTB;OEWuNFghdk1? MWHTRW5ITVJ?
639-V M4PSRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTh3LkSyJI5O MXLTRW5ITVJ?
NCI-H1048 NIP0UW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH2xN29KSzVyPUi2MlMyKG6P M3PsN3NCVkeHUh?=
NCI-H1573 M1jHXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHLTWM2OD16Nz60PEBvVQ>? NWfxUJU1W0GQR1XS
NCI-H2228 NUXYZlVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjEXnpKSzVyPUi4MlI3KG6P NFzD[|JUSU6JRWK=
NB14 NGnZPIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHycoRsUUN3ME24PE4{KG6P Mki1V2FPT0WU
SCC-25 NFXJVpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTjTWM2OD16OT64NkBvVQ>? M{nuO3NCVkeHUh?=
A431 M{\ueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVeyVlNkUUN3ME24PU46PyCwTR?= M2XuWXNCVkeHUh?=
SN12C NXSwPFhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7oNnpGUUN3ME25NE43OiCwTR?= NX\qT3g{W0GQR1XS
HuCCT1 M1S3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrTSnNKSzVyPUmwMlc3KG6P MXXTRW5ITVJ?
LS-123 NVrFepYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4C5bmlEPTB;OUKuNVghdk1? M3viXHNCVkeHUh?=
CAL-85-1 NHriUJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP2OXdkUUN3ME25Nk41QCCwTR?= MWTTRW5ITVJ?
ES6 M{PlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLtR5Y2UUN3ME25Nk45OyCwTR?= NV7wR|MyW0GQR1XS
NCI-H650 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\Pb|dKSzVyPUm0MlA6KG6P NVXnV453W0GQR1XS
NCI-H446 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTl3LkGyJI5O Ml\mV2FPT0WU
EW-13 M3P2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf5NohKSzVyPUm1Mlc2KG6P NIDnNZhUSU6JRWK=
HSC-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG2ZlNKSzVyPUm1Mlg6KG6P M3PxNHNCVkeHUh?=
U031 NH3MZ2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS2OllKSzVyPUm2Mlc{KG6P MYDTRW5ITVJ?
EW-11 NWLhZmdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT2TWM2OD17Nj64PEBvVQ>? NEm3VodUSU6JRWK=
GAK M4e2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq5TWM2OD17OD65N{BvVQ>? NF72SIZUSU6JRWK=
SK-OV-3 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HsfGlEPTB;MUCwMlA4KG6P MlruV2FPT0WU
OMC-1 NFHWOpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r2NGlEPTB;MUCwMlE5KG6P NH;pZ2RUSU6JRWK=
TK10 NWPPUXVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjncZZrUUN3ME2xNFAvOjFibl2= M1rSTXNCVkeHUh?=
EKVX MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnWfXhKSzVyPUGwNE43KG6P Mmi5V2FPT0WU
Detroit562 NX7rV2lUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLqbmg4UUN3ME2xNFIvOTdibl2= M4rHVHNCVkeHUh?=
SF268 M13SbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXGWWVKSzVyPUGwNk4{PCCwTR?= MUjTRW5ITVJ?
SNU-387 Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7hTWM2OD1zMESuNVchdk1? Mlu3V2FPT0WU
MDA-MB-231 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfrTWM2OD1zMEWuNFYhdk1? M3;y[nNCVkeHUh?=
NCI-H1563 NGDmUodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4f5SWlEPTB;MUC1MlE5KG6P M{H2N3NCVkeHUh?=
D-502MG NF;LPZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTFyNT63JI5O MmXEV2FPT0WU
A2780 NEPOcJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rrZmlEPTB;MUC2MlQ4KG6P Ml34V2FPT0WU
IA-LM MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTHV3JlUUN3ME2xNFcvPTFibl2= NYDscG5OW0GQR1XS
D-392MG NF2yRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXqW2xLUUN3ME2xNFcvPTRibl2= MWjTRW5ITVJ?
MS-1 NFPLfGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfqO3hKSzVyPUGwO{44OSCwTR?= MYDTRW5ITVJ?
SW1990 NVTaT5Z1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTFyOD61OEBvVQ>? NFTtVldUSU6JRWK=
HEL MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPWTWM2OD1zMEmuNlkhdk1? MnPGV2FPT0WU
SW1573 NWPKc2trT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTFyOT6zNUBvVQ>? NXi2Tlh1W0GQR1XS
SW1783 M{LjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPGTWM2OD1zMUCuNlIhdk1? MljTV2FPT0WU
COLO-680N MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LKdWlEPTB;MUGwMlc3KG6P MoKxV2FPT0WU
NCI-N87 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\lb4lKSzVyPUGxNU4xPCCwTR?= NH;QVm9USU6JRWK=
SK-MEL-28 NGW2RXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFThc4pKSzVyPUGxNU42PSCwTR?= MljaV2FPT0WU
BT-20 Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFzMj6wNUBvVQ>? MmHIV2FPT0WU
NCI-H1648 NFLzV5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXocVJHUUN3ME2xNVMhdk1? NV3COpZFW0GQR1XS
no-11 NVLlcWE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFzMz6yPEBvVQ>? Mk\KV2FPT0WU
MOLT-13 NUOwdIx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TwSGlEPTB;MUGzMlQ1KG6P Mo[wV2FPT0WU
NCI-H2170 NE\MOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTFzND61NUBvVQ>? M2DI[3NCVkeHUh?=
HTC-C3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T2ZmlEPTB;MUG2Mlg2KG6P MWHTRW5ITVJ?
LU-99A Mn;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;TTWM2OD1zMUeuNlEhdk1? M1TwS3NCVkeHUh?=
HCC2998 Ml32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnzPJhKUUN3ME2xNVcvQTJibl2= NUD1THRIW0GQR1XS
NB13 NX\RblRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3P0WmlEPTB;MUG3Mlk6KG6P M4\vc3NCVkeHUh?=
GT3TKB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjmNpBSUUN3ME2xNVgvODhibl2= NUHT[5pHW0GQR1XS
BT-549 M{H0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml62TWM2OD1zMUiuPVUhdk1? NUGzd|N{W0GQR1XS
NCI-H747 M2rx[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmwXIVKSzVyPUGxPU4{PCCwTR?= M4L2c3NCVkeHUh?=
EW-1 NH7WbIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NICxemFKSzVyPUGyNE4zKG6P NITYdI1USU6JRWK=
LB831-BLC M1q1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPETWM2OD1zMkCuOlMhdk1? MVXTRW5ITVJ?
NMC-G1 MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXFTWM2OD1zMkGuNVEhdk1? NYDlbmw5W0GQR1XS
COLO-679 NYjHU3lVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHlfYdKSzVyPUGyNk4yPSCwTR?= NVvuXHJZW0GQR1XS
HL-60 M1r6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVG4ZmhTUUN3ME2xNlMvOSCwTR?= NVXQVY8{W0GQR1XS
MKN7 NGnyelRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEmwb4hKSzVyPUGyN{45OyCwTR?= MVPTRW5ITVJ?
RERF-LC-MS Ml:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37EW2lEPTB;MUK0MlMyKG6P NH3EbI5USU6JRWK=
DMS-114 NFLCZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTF{NT6wPUBvVQ>? NV;keJZCW0GQR1XS
HuP-T4 NF63U4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[zXodrUUN3ME2xNlYvQTdibl2= MmrjV2FPT0WU
HCC2157 MmTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH2TWM2OD1zMkeuOUBvVQ>? NULZTpBQW0GQR1XS
SKG-IIIa NICy[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fBNGlEPTB;MUK4Mlghdk1? NGDyTW9USU6JRWK=
HCT-116 MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nWfmlEPTB;MUOwMlY1KG6P MWrTRW5ITVJ?
BB30-HNC NX31S3A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmGzTWM2OD1zM{CuO|ghdk1? M2DXfnNCVkeHUh?=
KYSE-270 MkjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;GTWM2OD1zM{CuPFghdk1? NVXJbpRxW0GQR1XS
MFM-223 NF;mdIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr6[lRUUUN3ME2xN|EvPTFibl2= MkfvV2FPT0WU
NH-12 M3nJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXxTWM2OD1zM{KuPVkhdk1? NXLmWlF7W0GQR1XS
U-118-MG M{\YPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF|Mz62NkBvVQ>? NIrPdHBUSU6JRWK=
ESS-1 NFXyWYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnBZ|dKSzVyPUGzOU4yQCCwTR?= MXHTRW5ITVJ?
D-247MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmToTWM2OD1zM{WuNlEhdk1? NGn6fY9USU6JRWK=
IGROV-1 NEmzfGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf4SGtNUUN3ME2xN|UvPzZibl2= NYDJSJFyW0GQR1XS
C-33-A MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTsTWM2OD1zM{WuPVchdk1? M4fWSHNCVkeHUh?=
NCI-H1693 MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TTWmlEPTB;MUO2MlEzKG6P M{W1bHNCVkeHUh?=
MLMA M2DCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnRTWM2OD1zM{[uOVghdk1? MojNV2FPT0WU
SK-N-AS NFnZOmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX1V41yUUN3ME2xN|cvOTdibl2= NEK2OXJUSU6JRWK=
NCI-H1755 NYHs[lVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnXTlZKSzVyPUGzPE45PSCwTR?= MWfTRW5ITVJ?
CHP-134 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfZWIFKSzVyPUGzPU42PSCwTR?= NIDyU4NUSU6JRWK=
LS-513 NWC1SpM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjOTWM2OD1zNECuPVEheE1? NH;odotUSU6JRWK=
TE-12 NGf1dJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnObIVKSzVyPUG0NE46OyCwTR?= MYjTRW5ITVJ?
KNS-42 NHPwd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDjTlFKSzVyPUG0OE4{KG6P M4S4U3NCVkeHUh?=
SJRH30 NILpeIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn3TWM2OD1zNESuOFQhdk1? MV\TRW5ITVJ?
NCI-H1092 NHKwN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF2ND61NkBvVQ>? MoraV2FPT0WU
H-EMC-SS M2DrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLOZVR4UUN3ME2xOFYvQDFibl2= NWfVUXg4W0GQR1XS
SK-MEL-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLzempKSzVyPUG0O{42PSCwTR?= MmfwV2FPT0WU
SK-N-FI NVfYPWlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLFTWM2OD1zNEeuOVkhdk1? MlL4V2FPT0WU
NCI-H2126 M4qzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Pqb2lEPTB;MUS4MlE2KG6P M1rIRnNCVkeHUh?=
NCI-H1299 NEW3U5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknhTWM2OD1zNUCuNlIhdk1? MoLRV2FPT0WU
CFPAC-1 MlfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f5fWlEPTB;MUWwMlY3KG6P M3PEWnNCVkeHUh?=
NCI-H661 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j2c2lEPTB;MUWxMlI3KG6P NWPzRYFSW0GQR1XS
KYSE-70 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3TV|VYUUN3ME2xOVEvPzlibl2= MUXTRW5ITVJ?
SW900 NEXyS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XEcWlEPTB;MUW0MlY2KG6P NXvab5gxW0GQR1XS
Ca-Ski NG[1XnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF3Nj6zPUBvVQ>? NUHZSWZRW0GQR1XS
HPAF-II MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnQOHZKSzVyPUG1Ok41PyCwTR?= NFOz[IJUSU6JRWK=
LB2518-MEL NH[4eVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjxemxKSzVyPUG1O{4yKG6P MnfTV2FPT0WU
LC-2-ad MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL0TWM2OD1zNUiuOlIhdk1? MXvTRW5ITVJ?
HCC1806 M2DyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofSTWM2OD1zNkeuPFghdk1? NGL3XZlUSU6JRWK=
UACC-62 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPQTWM2OD1zNkiuNFkhdk1? NHrVeIVUSU6JRWK=
KM-H2 MojhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX0V4xKSzVyPUG3NE42QCCwTR?= NVrNPI1OW0GQR1XS
NCI-H2347 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzJTWM2OD1zN{KuO|Ihdk1? MVfTRW5ITVJ?
SCC-15 M1ntZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCwVpJCUUN3ME2xO|MvPjZibl2= M3rReXNCVkeHUh?=
BB49-HNC MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi0V4tKUUN3ME2xO|MvQDFibl2= MlLMV2FPT0WU
GMS-10 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTF5Mz65OEBvVQ>? MXvTRW5ITVJ?
NCI-H2052 NEDzd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvDfWdKSzVyPUG3OE46KG6P M1ewfXNCVkeHUh?=
SW626 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PLN2lEPTB;MUe2MlA3KG6P MWDTRW5ITVJ?
MDA-MB-415 NH7uWodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTF5Nj62NUBvVQ>? MoTzV2FPT0WU
Saos-2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLwXnBuUUN3ME2xO|kvOzVibl2= NGLwOZpUSU6JRWK=
DK-MG MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTF6MD6zJI5O NX3HTIRsW0GQR1XS
SNU-C2B NVP5XoJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTF6MD63N{BvVQ>? NITXTIVUSU6JRWK=
A427 M2XCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF6Mj61O{BvVQ>? M3LrTHNCVkeHUh?=
KP-N-YS NHXEOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvWZ2M6UUN3ME2xPFUhdk1? NH\JSYZUSU6JRWK=
J82 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYexe2pVUUN3ME2xPFUvOThibl2= M1z1dXNCVkeHUh?=
LS-411N MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[zVoJLUUN3ME2xPFcvOjhibl2= NUHicW5WW0GQR1XS
HCC1937 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\2TVBKSzVyPUG4O{41QSCwTR?= MmfQV2FPT0WU
OE33 M174RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfmTWM2OD1zOEiuPVchdk1? M3vPZXNCVkeHUh?=
NB7 NIP6d|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j3eGlEPTB;MUi5Mlg6KG6P MoPEV2FPT0WU
SW684 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTITWM2OD1zOU[uNVMhdk1? NIDsOVRUSU6JRWK=
HT-144 NELwfFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13sfWlEPTB;MUm2MlE2KG6P MY\TRW5ITVJ?
SK-MEL-30 NYfWc|Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LJeWlEPTB;MUm2MlIhdk1? MnH2V2FPT0WU
DBTRG-05MG NFnG[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTF7OD60O{BvVQ>? NVLqTW1{W0GQR1XS
NCI-H1395 MkH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLJO4pWUUN3ME2xPVgvQDVibl2= MV7TRW5ITVJ?
NCI-H2122 NVywbG1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qzcGlEPTB;MkCwMlU6KG6P M1\qVnNCVkeHUh?=
no-10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJyMT6wOEBvVQ>? MlXWV2FPT0WU
SW48 M17GZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT6XYdWUUN3ME2yNFEvOzFibl2= M4ezR3NCVkeHUh?=
NCI-H1650 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLmTWM2OD1{MESuNFEhdk1? MYHTRW5ITVJ?
MZ1-PC NEfnT5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\4TWM2OD1{MEWuOVghdk1? MmXQV2FPT0WU
U-266 M2LRdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jxd2lEPTB;MkC1Mlc6KG6P M1LiUnNCVkeHUh?=
CAS-1 NEnWVWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEL0OXdKSzVyPUKwO{41PCCwTR?= MkiwV2FPT0WU
AU565 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJzMj64NkBvVQ>? NVnRNIR[W0GQR1XS
UACC-257 Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJzMz65PUBvVQ>? NVP2R5kzW0GQR1XS
CAL-27 NVfMfXpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfRTWM2OD1{MUeuNFUhdk1? NWX3XWEyW0GQR1XS
NCI-H23 M1\s[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorQTWM2OD1{MUmuN|Mhdk1? Mk\FV2FPT0WU
TE-6 M4XxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPTTWM2OD1{MUmuOlghdk1? NIWySndUSU6JRWK=
TGBC24TKB M1LEe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;tTWM2OD1{MkKuNVchdk1? MYLTRW5ITVJ?
TE-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmWxTWM2OD1{MkKuPFghdk1? MX7TRW5ITVJ?
RCC10RGB NHzN[WhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJ{ND6xPUBvVQ>? MmfwV2FPT0WU
NCI-H596 NXWwSmZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj4TWM2OD1{MkiuNlIhdk1? MXzTRW5ITVJ?
SW954 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3voeGlEPTB;MkOzMlg{KG6P NG\ZeXRUSU6JRWK=
NCI-H2087 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz0TWM2OD1{M{SuOVEhdk1? NXr5blRZW0GQR1XS
SK-PN-DW NEjwPGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D1OmlEPTB;MkO1MlE6KG6P NEnQWmVUSU6JRWK=
KM12 NIiwdo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTXSVBKSzVyPUKzOU44KG6P NFHoNVZUSU6JRWK=
BT-474 NIrlTVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXoTWM2OD1{M{WuO|Mhdk1? Mo\MV2FPT0WU
IST-MES1 Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3qx[WlEPTB;MkO2MlU4KG6P MWjTRW5ITVJ?
HT-1197 NFTvUlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHZTWM2OD1{M{iuNFkhdk1? MoDkV2FPT0WU
CAL-54 NFPiVGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fIWGlEPTB;MkO4MlQ6KG6P NGnkOJhUSU6JRWK=
NB10 NV\Oc|ByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33qemlEPTB;MkSwMlA3KG6P MUHTRW5ITVJ?
PANC-10-05 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDtfmViUUN3ME2yOFUvPTZibl2= Mn\YV2FPT0WU
NCI-H522 M2PZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnSSpZbUUN3ME2yOFgvOzFibl2= Mom3V2FPT0WU
A388 NFr0VotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfmPJdKSzVyPUK0PU45OiCwTR?= Ml7uV2FPT0WU
GOTO NXnrV|lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHITWM2OD1{NUCuNlkhdk1? NHXZZYxUSU6JRWK=
KLE Mnr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X0b2lEPTB;MkWxMlg4KG6P NUPQUlhFW0GQR1XS
KYSE-520 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJ3Mj64OkBvVQ>? MVjTRW5ITVJ?
HCE-4 NV\tU253T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TyVWlEPTB;Mk[yMlUhdk1? MVPTRW5ITVJ?
KURAMOCHI NF\GU|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXjPYpKSzVyPUK2OU46KG6P NFnu[oRUSU6JRWK=
HCC38 M2PnSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\tcGlEPTB;Mk[2MlQ5KG6P NIfi[HJUSU6JRWK=
FADU NIrJXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJ4Nj62N{BvVQ>? M2TMTXNCVkeHUh?=
CW-2 MnfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLLTWM2OD1{NkmuPVYhdk1? MUnTRW5ITVJ?
L-428 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTJ5NT6xOUBvVQ>? NX;rVXp{W0GQR1XS
HCC1569 NWHuOWpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7SZZNsUUN3ME2yO|UvQDRibl2= NVW2[ml3W0GQR1XS
NCI-H810 MnnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LEe2lEPTB;Mke4MlMyKG6P MXPTRW5ITVJ?
LB771-HNC NY\RbWNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLhU2t5UUN3ME2yPFUvQDRibl2= NXvKWWMyW0GQR1XS
LCLC-103H MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnwbZFVUUN3ME2yPFUvQTlibl2= NFXVdWZUSU6JRWK=
EFO-21 NYjhV|lXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJ6Nz62PEBvVQ>? MYrTRW5ITVJ?
CAL-72 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL1bXkzUUN3ME2yPVMvOTlibl2= MXXTRW5ITVJ?
SCC-9 NUTEV3lHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLtTWM2OD1{OUOuNlIhdk1? NIrWRYNUSU6JRWK=
COLO-829 MlfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrSTHRwUUN3ME2yPVYvPSCwTR?= NH:0XHpUSU6JRWK=
U-87-MG NF\ufFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF32SpZKSzVyPUOwNE44OyCwTR?= NHziUJhUSU6JRWK=
MZ7-mel NEjsU5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfiTWM2OD1|MkOuO|Yhdk1? Mlf5V2FPT0WU
NCI-H1770 NXGzWHBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjVT3RrUUN3ME2zNlYvPzRibl2= NYfuTIlqW0GQR1XS
ChaGo-K-1 NHzx[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnroTWM2OD1|MkiuNUBvVQ>? M1TI[HNCVkeHUh?=
SiHa NEe2WIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;TdGlEPTB;M{K5MlI1KG6P NHy4TYJUSU6JRWK=
NCI-SNU-5 NEDBUodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGH4V|NKSzVyPUOzOk44PyCwTR?= MkjiV2FPT0WU
DJM-1 M1nsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlSwTWM2OD1|NECuN|Mhdk1? MXjTRW5ITVJ?
OE19 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzYeZRYUUN3ME2zOFAvPTNibl2= NFnHOmVUSU6JRWK=
NCI-H1651 NEDVTlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTN2ND6xPEBvVQ>? MkniV2FPT0WU
COLO-792 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLC[ndpUUN3ME2zOVQvPDJibl2= NXjGVGJXW0GQR1XS
ACHN NWLmcHpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3iyb2lEPTB;M{W2MlcyKG6P MUTTRW5ITVJ?
TH-3 MmrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTN5OT65OUBvVQ>? MV3TRW5ITVJ?
HT-1376 NIfCfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT6TWM2OD1|OESuPFghdk1? NUnCT456W0GQR1XS
RH-18 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP3XFhSUUN3ME2zPVQvPzRibl2= MkTDV2FPT0WU
NB6 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTpV4VKSzVyPUO5Ok43PiCwTR?= Ml6wV2FPT0WU
COLO-320-HSR NFLhPWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTRyMz6zO{BvVQ>? MWHTRW5ITVJ?
UACC-893 NYjWSmJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfSTWM2OD12ME[uOFchdk1? NFnWbXZUSU6JRWK=
DSH1 MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLxTWM2OD12ME[uPVEhdk1? NHnGTndUSU6JRWK=
TE-10 NWH5VIszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3jNXVnUUN3ME20NFcvODFibl2= MYrTRW5ITVJ?
HCC70 M4HGPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYT5RVB5UUN3ME20NFkvOjFibl2= Mn[2V2FPT0WU
TGBC11TKB MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljtTWM2OD12MUCuN|Mhdk1? MYDTRW5ITVJ?
NCI-H727 M{TQe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDibm5KSzVyPUSxNk4yOSCwTR?= M4XobHNCVkeHUh?=
ALL-PO M{LoNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmToTWM2OD12MUWuOlkhdk1? NVyyTXRlW0GQR1XS
ABC-1 Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2S2WWlEPTB;NEKwMlQ2KG6P NVv1S2N4W0GQR1XS
NCI-H69 NGHwOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3DWGk1UUN3ME20NlYvPzZibl2= M{LOcXNCVkeHUh?=
GP5d NXmwWnNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFuyTI1KSzVyPUSzOE41OSCwTR?= NF2wRlJUSU6JRWK=
UMC-11 NFrnNVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS4TWM2OD12NUiuN|Yhdk1? NIq2PXZUSU6JRWK=
RMG-I MnO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW1TWM2OD12NkeuOVYhdk1? MnrRV2FPT0WU
YAPC M2HHVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnGPWdDUUN3ME20PVAvPiCwTR?= Mn3DV2FPT0WU
LS-1034 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXxfHoxUUN3ME20PVEvODZibl2= MYnTRW5ITVJ?
RCM-1 MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvtZZdKSzVyPUS5Ok43QCCwTR?= M3zaSXNCVkeHUh?=
HCC1954 M3rNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rqNmlEPTB;NUGyMlUhdk1? M4XoU3NCVkeHUh?=
SK-MEL-24 M{TMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fpZmlEPTB;NUG2MlUyKG6P NFuyPWpUSU6JRWK=
NB12 NGPDcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPhWmxKSzVyPUWyPE41OiCwTR?= NVn0S2I5W0GQR1XS
SW756 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe0eodKSzVyPUW1OE46PiCwTR?= NHzZWnBUSU6JRWK=
HCC1187 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTV5NT64N{BvVQ>? NYjCZZg{W0GQR1XS
NCI-H2342 NVTEPXlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH1epRHUUN3ME21PVAvOzlibl2= MlzLV2FPT0WU
NCI-H2291 NVT0cYVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W1SmlEPTB;NUm4MlMyKG6P M1PuZ3NCVkeHUh?=
OVCAR-3 NUjLRVMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTsbJhKSzVyPUW5PE46PiCwTR?= M4nJWXNCVkeHUh?=
MHH-NB-11 NGHWfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW4TWM2OD14MkmuNFEhdk1? MULTRW5ITVJ?
SAS MnHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO0TWM2OD14NUKuOlchdk1? MU\TRW5ITVJ?
COLO-824 NEC0bIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDWXoRKSzVyPU[4PU4{PyCwTR?= NXnGNIJQW0GQR1XS
HCC1395 MlXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v5[GlEPTB;Nkm4MlUhdk1? MWTTRW5ITVJ?
COLO-668 MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXGe|lKSzVyPUewOk4yKG6P NVfkfpBQW0GQR1XS
NCI-H226 MoDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLXblJKUUN3ME23NFcvQCCwTR?= Ml31V2FPT0WU
NB17 M4SxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3G1fWlEPTB;N{KxMlc2KG6P M4fibnNCVkeHUh?=
SW1463 NXzQWnpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rl[2lEPTB;N{O5MlE6KG6P NWrkfJhtW0GQR1XS
TGW M3jSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jXRWlEPTB;N{[wMlE2KG6P MXPTRW5ITVJ?
NCI-H526 M2DmNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrSTWM2OD16MkOuOVMhdk1? M4fYXXNCVkeHUh?=
COR-L88 M4\6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTl[IpKSzVyPUi0PE4yOiCwTR?= NGPUUlFUSU6JRWK=
NCI-H441 M1;yV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\YbGlEPTB;OEm1MlIzKG6P M{W0c3NCVkeHUh?=
NCI-H630 NYjET4R7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPtTWM2OD17MUKuPVYhdk1? MVHTRW5ITVJ?
Mo-T NHXJR4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fMUGlEPTB;OUS3Mlg5KG6P NFuw[plUSU6JRWK=
JAR MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTl3Nj6yOEBvVQ>? NYLWe4dNW0GQR1XS
NCI-H1838 NFfXUlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rxTmlEPTB;MT6wNlM5QCEQvF2= NWT5S5BTW0GQR1XS
DoTc2-4510 NXXJb25uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K3XmlEPTB;MT6wO|M4PiEQvF2= MYrTRW5ITVJ?
MKN28 M{XrZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfUTWM2OD1zLkC5NFI1KM7:TR?= MYXTRW5ITVJ?
HuP-T3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGezNXRKSzVyPUGuNVE6ODVizszN MX7TRW5ITVJ?
TE-9 MmTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDFPFBXUUN3ME2xMlEzQTd|IN88US=> MUHTRW5ITVJ?
NY NUTmfI45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwMU[3PVIh|ryP MXXTRW5ITVJ?
HT55 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXKTWM2OD1zLkOxN|Q1KM7:TR?= NIe5O4FUSU6JRWK=
SW837 MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrnOGVLUUN3ME2xMlMzQTd6IN88US=> M3v1U3NCVkeHUh?=
NCI-H2029 NY\uVml7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHflVlhKSzVyPUGuOFE4QTFizszN M1S5UnNCVkeHUh?=
IST-SL1 MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTFwNESyOEDPxE1? NXW1Wo14W0GQR1XS
COLO-741 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrreGlYUUN3ME2xMlQ6PzdzIN88US=> Mlz3V2FPT0WU
LU-65 NVja[5ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr6TWM2OD1zLk[yNlQ6KM7:TR?= Ml;tV2FPT0WU
NCI-H1304 NF\QXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7k[5BmUUN3ME2xMlY2PDl6IN88US=> NGLzR|hUSU6JRWK=
KARPAS-299 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HoV2lEPTB;MT63PVQ4QSEQvF2= MkPFV2FPT0WU
NCI-H358 NEi2OYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFwOUW1NFMh|ryP M3fDcHNCVkeHUh?=
OAW-28 M4fPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37qeGlEPTB;Mj6wOlkyQSEQvF2= MkeyV2FPT0WU
C8166 NUDN[3czT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJwNkOzPVIh|ryP MnT2V2FPT0WU
COLO-678 NGfLbY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7rVXVKSzVyPUKuPFM4PjhizszN MU\TRW5ITVJ?
SK-N-DZ NUDrcohpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJwOE[zPFEh|ryP NGLy[ZNUSU6JRWK=
NCI-H82 NFLw[IFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv3e2lqUUN3ME2yMlkxOzZ7IN88US=> MmjkV2FPT0WU
JVM-2 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTNwMEOxPFgh|ryP NHvOVXFUSU6JRWK=
SW1116 NEi2elBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ewVWlEPTB;Mz6wOVQyOSEQvF2= M2XWOXNCVkeHUh?=
MDA-MB-453 MnPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;1WmlEPTB;Mz6xNFQ{QSEQvF2= MV\TRW5ITVJ?
Calu-6 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvUSoZ6UUN3ME2zMlE6QTdizszN MU\TRW5ITVJ?
SHP-77 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrqdXpKSzVyPUOuOVI5KM7:TR?= M2TucnNCVkeHUh?=
Capan-2 M2PIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPnfGRKSzVyPUSuN|I2QDFizszN M1vwVHNCVkeHUh?=
SW948 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnThTWM2OD12Lke0O|c6KM7:TR?= NVTHRnY2W0GQR1XS
HDLM-2 NF\COIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TFb2lEPTB;NT6wO|czPSEQvF2= NETQfIRUSU6JRWK=
LAN-6 NG\aNGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTZwMkG0PVUh|ryP NXnLdHMzW0GQR1XS
LU-135 NFToTGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\FTWM2OD14LkSzNFc4KM7:TR?= MYfTRW5ITVJ?
T84 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTZwOUi2OEDPxE1? NVTQbVc6W0GQR1XS
CAPAN-1 NXrCc4dwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfpcHpPUUN3ME23MlYzOjN|IN88US=> NFLYWZNUSU6JRWK=
SW1417 M4Xh[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3MTWM2OD15LkmxO|MyKM7:TR?= Mnz1V2FPT0WU
BALL-1 MoH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHZXFI3UUN3ME24MlUxPDB7IN88US=> M4fl[nNCVkeHUh?=
HT-29 NULWXHFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvWTWM2OD17LkC3OVk6KM7:TR?= NHfrbIJUSU6JRWK=
C3A MnXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTlwOEizPVQh|ryP MWDTRW5ITVJ?
NCI-H1993 NVrNToVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7XUmZjUUN3ME2xNE42ODhzIN88US=> NH3T[WNUSU6JRWK=
SK-MEL-1 M33GWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjCTWM2OD1zMT62Nlg6KM7:TR?= MU\TRW5ITVJ?
DU-145 NWX0S4V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvVeXdKSzVyPUG0MlUxPTJizszN Mn\WV2FPT0WU
KP-N-YN MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF2LkWxNFMh|ryP NH;wW5ZUSU6JRWK=
CCRF-CEM NUeyV5B{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoD1TWM2OD1zND63PFA6KM7:TR?= MXPTRW5ITVJ?
ZR-75-30 MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG5coF3UUN3ME2xOk4{OzB|IN88US=> MoXjV2FPT0WU
A673 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjVbGNKSzVyPUKwMlU2ODdizszN NEHBV2pUSU6JRWK=
K-562 MmTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfYdGtKSzVyPUK4MlQyQDNizszN MX7TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

In vitro Protein Kinase, PI3K, and mTOR Assays PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.

細胞アッセイ:

[2]

細胞株 HCT116, DLD-1 and SW480 cells
濃度 0-1 μM
反応時間 48 hours
実験の流れ

The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.

動物実験:

[1]

動物モデル Female Harlan athymic nude mice
製剤 NMP/polyethylene glycol 300 (10/90, v/v)
投薬量 45 mg/kg
投与方法 p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BEZ235 (NVP-BEZ235, Dactolisib) SDF
分子量 469.55
化学式

C30H23N5O

CAS No. 915019-65-7
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
<1 mg/mL (<1 mM)
In vivo NMP/polyethylene glycol 300 (10/90, v/v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

カスタマーフィードバック (8)


Click to enlarge
Rating
Source Cancer Res, 2010, 70, 4982-4994. BEZ235 (NVP-BEZ235, Dactolisib) purchased from Selleck
Method Detection of lipid kinase activities of PI3K p110α mutants
Cell Lines HEK293T cells
Concentrations
Incubation Time
Results "Evaluation of relative kinase activity of these mutants revealed that mutant P449T exhibited gain of function (>2-fold) compared with wild-type PI3K α (Fig. A). With regard to two hotspot mutants (E545K and H1047R), we examined the effect of NVP-BEZ235 and other PI3K inhibitors on their enzymatic activity and found no striking difference in their efficacies compared with wild-type p110α (Fig. B).

Click to enlarge
Rating
Source Clin Cancer Res, 2010, 16, 6029-6039. BEZ235 (NVP-BEZ235, Dactolisib) purchased from Selleck
Method Synergism studies, Immunoblot assays, Clonogenic assays
Cell Lines Melanoma cell
Concentrations 0.1-100 μM
Incubation Time 1-24 h
Results One of the proposed mechanisms of resistance to PI3KIs is mutation in the Ras-Raf pathway, which are found in more than half of melanomas. By ANOVA, no association was found between the IC50 values of NVP-BEZ235 and the presence or absence of B-Raf mutations (Fig. A). The targets of NVP-BEZ235, pAkt and pP70S6K, were both decreased with exposure to the drug in a time- and dose-dependent fashion, as shown in Figure B for YUVON and YUSIK cell lines. Clonogenicity was studied in YUVON and YUSIK cells with exposure to the dual PI3K/mTOR inhibitor. As shown in Figure C, NVP-BEZ235 effectively inhibits clonogenicity at low nanomolar concentrations.

Click to enlarge
Rating
Source Breast Cancer Res , 2011, 13, R52. BEZ235 (NVP-BEZ235, Dactolisib) purchased from Selleck
Method Immunofluorescence staining
Cell Lines MCF7 cells, IGF1R cells
Concentrations
Incubation Time
Results We investigated the effect of IGF-1 stimulation on MCF7/IGF-1R 4-OH-TAM resistance in a structurally and physiologically relevant context by use of a modified 3D culture. Both parental MCF7 (Figure a) and MCF7/IGF-1R cells (Figure b) were responsive to E2 or IGF-1 by forming acini on Matrigel, but the response was significantly larger in MCF7/IGF-1R cells with altered a cinar morphogenesis. inhibition of IGF -1R/ERK/Akt signaling by respective kinase inhibitors restored 4-OH-TAM sensitivity of MCF7/IGF-1R cells in 3D culture (Figure c).

Click to enlarge
Rating
Source Breast Cancer Res, 2011, 13:R52. BEZ235 (NVP-BEZ235, Dactolisib) purchased from Selleck
Method Western blot, A sulforhodamine B ( SRB) colorimetric assay
Cell Lines MCF7 cells, GF-1R cells
Concentrations 0.01-10 μM
Incubation Time
Results IGF-1-stimulated proliferation was drastically restrained by BEZ235 at either 1 or 10 μM (Figure a).While IGF-1R and ERK signaling remained unaffected in response to IGF-1, the phosphorylation level of Akt was diminished with an increase in the dose of BEZ235, largely at 0.1 μM and entirely at 0.5 μM (Figure b). Likewise, the cell proliferation rate decreased correspondingly to Akt phosphorylation levels, significantly dropping at 0.1μM BEZ235 (Figure c)

Click to enlarge
Rating
Source Eur J Cancer, 2010, 46, 1111-1121. BEZ235 (NVP-BEZ235, Dactolisib) purchased from Selleck
Method LanthaScreen assay
Cell Lines JFCR39 cell lines
Concentrations 0.016 μM
Incubation Time
Results As shown in Fig. A, NVP-BEZ235 and other inhibitors all inhibited mTOR in a dose-dependent manner. The IC50 values were calculated and are shown in Fig. B. NVP-BEZ235 inhibited mTOR potently, with IC50 value of 0.002 μM. In contrast, ZSTK474, GDC-0941 and LY294002 weakly inhibited mTOR, with IC50 values of 0.377, 0.413 and 3.86μM, respectively. To further demonstrate their selectivity for class I PI3K, the IC50 values of these inhibitors for mTOR were divided by their corresponding IC50s for class I PI3Ka, and the resulting ratios were plotted in Fig. C. Clearly, ZSTK474 and GDC-0941 revealed much higher selectivity for inhibiting class I PI3K than the other two inhibitors. In contrast, NVP-BEZ235 more potently inhibited the activity of mTOR than that of class I PI3K

Click to enlarge
Rating
Source Dr. Zhang of Tianjin Medical University. BEZ235 (NVP-BEZ235, Dactolisib) purchased from Selleck
Method Western blot
Cell Lines breast cancer cells
Concentrations 0-10 nM
Incubation Time 3 h
Results

Click to enlarge
Rating
Source Dr. Zhang of Tianjin Medical University. BEZ235 (NVP-BEZ235, Dactolisib) purchased from Selleck
Method Western blot
Cell Lines breast cancer cells
Concentrations 0-50 nM
Incubation Time 3 h
Results

Click to enlarge
Rating
Source BEZ235 (NVP-BEZ235, Dactolisib) purchased from Selleck
Method Western Blotting
Cell Lines xenografts
Concentrations
Incubation Time
Results Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts.

文献中の引用 (80)

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related PI3K 阻害剤

  • GDC-0032

    GDC-0032 is a potent, next-generation PI3K inhibitor targeting PI3K alpha.

    Features:A beta isoform-sparing PI3K inhibitor.

  • Pilaralisib (XL147)

    Pilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2.

  • GNE-317

    GNE-317 is a potent, brain-penetrant PI3K inhibitor.

  • PI-3065

    PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, >70-fold selectivity over other PI3K family members.

  • LY294002

    LY294002は、p110α、p110δとp110βのPI3K阻害剤で、IC50 がそれぞれ 0.5 μM、0.57 μM、0.97 μMです。

  • 3-Methyladenine (3-MA)

    3-Methyladenine (3-MA) は選択の自噬とリン酸イノシトール3キナーゼ(キナーゼ)阻害剤、Vps34 と PI3Kγ に作用する時、 IC50 がそれぞれ 25 nM と 60 nM になる。自動食物胞の形成を妨害すること。

  • CAL-101 (Idelalisib, GS-1101)

    CAL-101 (Idelalisib, GS-1101)は、2.5nMのIC50によるp110δの選択的なPI3KクラスI阻害剤です。

  • Wortmannin

    ワートマニンはミオシン軽鎖キナーゼ(MLCK)のマルチターゲットの阻害剤、IC50がぞれぞれ0.17μMと3nMになる。自動食物胞の形成を妨害すること。

  • BKM120 (NVP-BKM120, Buparlisib)

    BKM120 (NVP-BKM120, Buparlisib)は、p110α、p110β、p110δとp110γの選択的なPI3K阻害剤で、IC50 がそれぞれ 52-99 nM、166 nM、 116 nM、 262 nMです。

最近チェックしたアイテム

Tags: BEZ235 (NVP-BEZ235, Dactolisib)を買う | BEZ235 (NVP-BEZ235, Dactolisib)供給者 | BEZ235 (NVP-BEZ235, Dactolisib)を購入する | BEZ235 (NVP-BEZ235, Dactolisib)費用 | BEZ235 (NVP-BEZ235, Dactolisib)生産者 | オーダーBEZ235 (NVP-BEZ235, Dactolisib) | BEZ235 (NVP-BEZ235, Dactolisib)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ