BEZ235 (NVP-BEZ235, Dactolisib) 化学構造
分子量: 469.55

高品質保証

文献中の引用(81)

カスタマーフィードバック(8)

Quality Control & MSDS

製品説明

  • Compare PI3K Inhibitors
    PI3K製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 BEZ235 (NVP-BEZ235, Dactolisib)は競争性的なPI3K、mTOR 阻害剤、 p110α, p110γ, p110δ と p110β を作用すると、 IC50 がぞれぞれ 4 nM, 5 nM, 7 nM と 75 nMになる.
ターゲット

p110α

p110γ

p110δ

p110β

ATR

IC50

4 nM

5 nM

7 nM

75 nM [1]

21 nM [8]

In vitro試験 BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
Trypanosoma brucei brucei NEfi[WdCdnSrbXnjdo9jcWGuIFHzd4F6 M3rLTlE5KGh? MVTEUXNQ MWTBcpRqfHK7cHHuc5NwdWGuIHHjeIl3cXS7IIfpeIghTUN3MDDv[kAxNjByMkWg{txO MmPrNlQ5ODV7NE[=
MCF7 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O0blAvODFvMUCwJO69VQ>? NUn3So9DPDhiaB?= MUXEUXNQ NXOxV5FIUUN3ME2wMlc{KM7:TR?= M3e2WlI{QDdzOUC0
HCT116 NXXvUIhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLteGhLOC5yMT2xNFAh|ryP NF\yXYg1QCCq M2juXmROW09? NWXXTHBRUUN3ME2xMlE3KM7:TR?= M1K0RVI{QDdzOUC0
U87MG NFS0c2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTIOHhYOC5yMT2xNFAh|ryP NV\5c5A6PDhiaB?= M2DDWWROW09? MWnJR|UxRTFwM{Kg{txO M4XVSlI{QDdzOUC0
HBC4 M3SxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXq1S4hzOC5yMT2xNFAh|ryP M4OySVQ5KGh? NF[5NmxNd2diR1m1NF0uQC54MTDN MXGyNlM{PjJ2Nh?=
BSY1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;BNVQxNjBzLUGwNEDPxE1? NIjzR441QCCq M3jxWWxw\yCJSUWwQU05NjR6IF2= MXOyNlM{PjJ2Nh?=
HBC5 NH3nU4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPYXWkxNjBzLUGwNEDPxE1? M1HUd|Q5KGh? NWDiU3cxVG:pIFfJOVA:NTdwOEegUS=> Mn;2NlI{OzZ{NE[=
MCF7 NG\OeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnGNE4xOS1zMECg{txO NIPjfWE1QCCq NWfsV|dLVG:pIFfJOVA:NThwMU[gUS=> Mm\TNlI{OzZ{NE[=
MDA-MB-231 NH;pXmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP5fFExNjBzLUGwNEDPxE1? MXq0PEBp MmTOUI9oKEeLNUC9MVgvODliTR?= NVToXmdZOjJ|M{[yOFY>
U251 MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvxU2gxNjBzLUGwNEDPxE1? MYS0PEBp MXfMc4chT0l3ME2tO{43PiCP NFqwWnMzOjN|NkK0Oi=>
SF268 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjhNE4xOS1zMECg{txO MnTJOFghcA>? MULMc4chT0l3ME2tO{46OiCP NFrqNoEzOjN|NkK0Oi=>
SF295 NFfKdnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUOwMlAyNTFyMDFOwG0> NH\0NFY1QCCq NH3KWmtNd2diR1m1NF0uQC5|MTDN MmDMNlI{OzZ{NE[=
SF539 M2rMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUWwMlAyNTFyMDFOwG0> NEPrWWQ1QCCq Mm\tUI9oKEeLNUC9MVgvPTliTR?= MkfnNlI{OzZ{NE[=
SNB75 Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zsfVAvODFvMUCwJO69VQ>? NFPJXZA1QCCq M3j2XGxw\yCJSUWwQU05NjV6IF2= MWmyNlM{PjJ2Nh?=
SNB78 NH7XdI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XNdlAvODFvMUCwJO69VQ>? NVvmXJViPDhiaB?= MV7Mc4chT0l3ME2tPE43PSCP MVyyNlM{PjJ2Nh?=
HCC2998 NI\5VFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV:wMlAyNTFyMDFOwG0> MX:0PEBp MoTpUI9oKEeLNUC9MVgvODViTR?= NILWcXUzOjN|NkK0Oi=>
KM12 NYnMXlFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\jbVAvODFvMUCwJO69VQ>? MU[0PEBp MWjMc4chT0l3ME2tO{42PCCP NFHQOGozOjN|NkK0Oi=>
HT-29 M1fM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT6W4Y1OC5yMT2xNFAh|ryP MUe0PEBp NYGwbFk1VG:pIFfJOVA:NTdwN{WgUS=> M{XXbFIzOzN4MkS2
HCT15 M1jkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuzNE4xOS1zMECg{txO MYG0PEBp MX\Mc4chT0l3ME2tPE4xOyCP MmLDNlI{OzZ{NE[=
HCT116 MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjtc5g3OC5yMT2xNFAh|ryP MVK0PEBp MYLMc4chT0l3ME2tO{43OSCP NVLwNoUxOjJ|M{[yOFY>
NCI-H23 NV\MbFVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;mS20xNjBzLUGwNEDPxE1? Ml63OFghcA>? MWXMc4chT0l3ME2tO{43PCCP NW\wWGVUOjJ|M{[yOFY>
NCI-H226 M3LrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\uSVAvODFvMUCwJO69VQ>? NIG3PWQ1QCCq NWLpUXJ[VG:pIFfJOVA:NThwNESgUS=> MkfiNlI{OzZ{NE[=
NCI-H522 M1PVPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXh[lByOC5yMT2xNFAh|ryP NILKOXc1QCCq M4iwZ2xw\yCJSUWwQU05NjR3IF2= MV2yNlM{PjJ2Nh?=
NCI-H438 NGXyfVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml60NE4xOS1zMECg{txO MYC0PEBp NUj2[WRKVG:pIFfJOVA:NThwMUGgUS=> NGTJUmIzOjN|NkK0Oi=>
A549 NGjje3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDTfWUxNjBzLUGwNEDPxE1? M{TCU|Q5KGh? MkP5UI9oKEeLNUC9MVgvODdiTR?= NID2bpozOjN|NkK0Oi=>
DMS273 MoXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\FbYgxNjBzLUGwNEDPxE1? MlS1OFghcA>? Mk\tUI9oKEeLNUC9MVcvQDBiTR?= MorJNlI{OzZ{NE[=
DMS114 M3znW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVewMlAyNTFyMDFOwG0> NYXyPZlbPDhiaB?= NHnTVVhNd2diR1m1NF0uQC5|OTDN NEfXVoUzOjN|NkK0Oi=>
LOXIMVI MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD3NE4xOS1zMECg{txO MXu0PEBp M3XhfGxw\yCJSUWwQU05NjZ4IF2= MWKyNlM{PjJ2Nh?=
OVCAR3 NIj6T|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVKxPGJ6OC5yMT2xNFAh|ryP NULqd4Y{PDhiaB?= MWHMc4chT0l3ME2tPE4yPyCP NUDRdGV4OjJ|M{[yOFY>
OVCAR4 NUHh[GJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHHbG0xNjBzLUGwNEDPxE1? NEizO|E1QCCq NG[5OXNNd2diR1m1NF0uQC53ODDN NYfOOIVLOjJ|M{[yOFY>
OVCAR5 NHP1VlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z5UFAvODFvMUCwJO69VQ>? NGrWZ5E1QCCq MkLkUI9oKEeLNUC9MVcvPTdiTR?= M1mxUFIzOzN4MkS2
OVCAR8 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTSNE4xOS1zMECg{txO NEK0TFY1QCCq NIDYPGFNd2diR1m1NF0uPy56NDDN M3vFSFIzOzN4MkS2
SKOV3 M3L6PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjoc5g3OC5yMT2xNFAh|ryP M1LPPVQ5KGh? MWHMc4chT0l3ME2tPE41OSCP NV\a[HhLOjJ|M{[yOFY>
RXF631L NWnNbm1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7sfWVvOC5yMT2xNFAh|ryP Ml\HOFghcA>? MY\Mc4chT0l3ME2tPE4zOSCP NILBblEzOjN|NkK0Oi=>
ACHN NVfPdIJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDyWXhQOC5yMT2xNFAh|ryP MVW0PEBp NGfO[YlNd2diR1m1NF0uPy57NTDN MYOyNlM{PjJ2Nh?=
St-4 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXWwMlAyNTFyMDFOwG0> M2PxOVQ5KGh? M4PXPGxw\yCJSUWwQU04NjR5IF2= NVzsVI5[OjJ|M{[yOFY>
MKN1 NF;SbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn25NE4xOS1zMECg{txO NG\oUno1QCCq M4nlUmxw\yCJSUWwQU05NjRzIF2= MnfENlI{OzZ{NE[=
MKN7 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLENE4xOS1zMECg{txO MlnMOFghcA>? NV;6c2xyVG:pIFfJOVA:NTdwNkigUS=> NUTCRZFuOjJ|M{[yOFY>
MKN28 M{fqR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFy3UpYxNjBzLUGwNEDPxE1? NXmwS3Y3PDhiaB?= MoDYUI9oKEeLNUC9MVcvODdiTR?= MoryNlI{OzZ{NE[=
MKN45 NHvhVYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm4ZnMxNjBzLUGwNEDPxE1? MXO0PEBp NUfuVVRSVG:pIFfJOVA:NThwM{SgUS=> MnexNlI{OzZ{NE[=
MKN74 NHHVRVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH6NE4xOS1zMECg{txO NHn2T2s1QCCq MnviUI9oKEeLNUC9MVcvPDJiTR?= MX6yNlM{PjJ2Nh?=
DU145 NYPYNJduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjtRYoxNjBzLUGwNEDPxE1? MUW0PEBp MXXMc4chT0l3ME2tPE4yPiCP M{e3ZVIzOzN4MkS2
PC3 NWrLNnI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHSNE4xOS1zMECg{txO M{DafVQ5KGh? M2[5Zmxw\yCJSUWwQU05NjZ4IF2= MXKyNlM{PjJ2Nh?=
Trypanosoma brucei brucei M2TqTGZ2dmO2aX;uJGF{e2G7 MWqyNFAhdk1? M{jXc|EzKGh? MkjjSG1UVw>? MlLlSIVkemWjc3WgbY4heGixc4Doc5Rq\HmuIHnuc5NqfG:uIIDoc5NxcGG2ZTDs[ZZmdA>? M2jqfFI1QDB3OUS2
Trypanosoma brucei brucei NIW3ZZhHfW6ldHnvckBCe3OjeR?= MnfKNVghcA>? NFHXNXVFVVOR M1;PeGlvcGmkaYTpc44hd2ZicnXj[ZB1d3JvbXXkbYF1\WRiZX7kc4N6fG:|aYOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5idILhcpNn\XK{aX6geZB1[Wun M3rZfFI1QDB3OUS2
Trypanosoma brucei brucei NUPLVJh6TnWwY4Tpc44hSXO|YYm= NWm5U2VXOjByIH7N M3HhWVEzKGh? M{Tme2ROW09? NVHKWm5iTW[oZXP0JI9vKHOyaHnu[49ugWynaX6gcIV3\Wx? NF3C[YwzPDhyNUm0Oi=>
Trypanosoma brucei brucei NFvkfIhHfW6ldHnvckBCe3OjeR?= MX6yNFAhdk1? NF3D[WUyOiCq NH\uWWJFVVOR MV7F[oZm[3Rib36gdIhwe3CqYYTp[Jlt[2ixbHnu[UBt\X[nbB?= M1jj[lI1QDB3OUS2
UM-UC-3 M3jxeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXFTWM2OD1|MUWgdG0> NVrld4Z[W0GQR1XS
SBC-1 M2L1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjWTWM2OD15NEKgdG0> NVTEXYlRW0GQR1XS
MKN1 MnryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJwODDuUS=> NXrONGJWW0GQR1XS
NCI-H720 NVu5dYE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3e3TmlEPTB;Mz61O{BvVQ>? NYHGV3gxW0GQR1XS
BFTC-909 NFfHbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTNwN{Ggcm0> Ml\EV2FPT0WU
BPH-1 M3viXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTRwN{[gcm0> M4fXWXNCVkeHUh?=
PC-3 M3O1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofsTWM2OD13LkC5JI5O NHHvZmxUSU6JRWK=
AN3-CA NETwU2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DFcWlEPTB;NT61OkBvVQ>? M4e1RXNCVkeHUh?=
HN MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe5Nmg5UUN3ME21Mlk3KG6P MXPTRW5ITVJ?
HCC2218 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;PWWlEPTB;Nj62NUBvVQ>? MUXTRW5ITVJ?
KP-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvSTWM2OD15IH7N M3jCNXNCVkeHUh?=
LU-139 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTZNIZFUUN3ME23Mlc4KG6P MYHTRW5ITVJ?
ETK-1 NYD6[Y06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTdwOEigcm0> MlfqV2FPT0WU
Ramos-2G6-4C10 NITyO4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn2bWNKSzVyPUiuOFkhdk1? Ml;iV2FPT0WU
MHH-PREB-1 NF3idnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSzTWM2OD17LkGyJI5O MmnrV2FPT0WU
DU-4475 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[4ZpZHUUN3ME25MlQ1KG6P NIXrOVNUSU6JRWK=
NCI-H1666 NHfhNIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTlwN{Ggcm0> MnzOV2FPT0WU
CAMA-1 NVKxVFgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTlwODDuUS=> MoezV2FPT0WU
TYK-nu NIPDO2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[1S5lKSzVyPUmuPVQhdk1? Mo\LV2FPT0WU
MFE-280 MmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLZdYRKSzVyPUmuPVkhdk1? NHHBPYhUSU6JRWK=
A549 NGWxTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXPeI9iUUN3ME2xNE4yPCCwTR?= MmjMV2FPT0WU
769-P NUXzU2dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELLb5FKSzVyPUGwMlQ1KG6P MnHJV2FPT0WU
L-363 NVn6XXh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3uTWM2OD1zMD62PUBvVQ>? NIX6O2RUSU6JRWK=
ES8 NIXZSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\FTWM2OD1zMD65JI5O M2XQbXNCVkeHUh?=
PA-1 Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDpZ3RKSzVyPUGxMlgzKG6P MlPyV2FPT0WU
Mewo MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFzLkm5JI5O NXqzOWZmW0GQR1XS
HSC-3 MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF{LkKxJI5O MmHDV2FPT0WU
H4 NYjCS5hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7BTnRKSzVyPUGyMlY4KG6P MYnTRW5ITVJ?
BB65-RCC NXjSO4JoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLme|JFUUN3ME2xNk44OiCwTR?= NFHROIhUSU6JRWK=
NCI-H1793 M4HncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTZTWM2OD1zMj64NkBvVQ>? M4PRdnNCVkeHUh?=
KARPAS-45 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF|LkWxJI5O MWHTRW5ITVJ?
GCT MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTrTWM2OD1zMz62PEBvVQ>? NID3dFFUSU6JRWK=
EoL-1 NGfkTWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH6xNoRKSzVyPUGzMlk{KG6P NX\wUlFDW0GQR1XS
LB2241-RCC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXsTWM2OD1zND6wNUBvVQ>? MlP1V2FPT0WU
ES5 NV;kSHByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEmyeIRKSzVyPUG0Mlc1KG6P NImzTXlUSU6JRWK=
LOXIMVI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfjfmVKSzVyPUG0Mlk6KG6P Mli0V2FPT0WU
COR-L105 NXnPR4ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYKwOG5lUUN3ME2xOU4xPCCwTR?= M3:4SXNCVkeHUh?=
P12-ICHIKAWA MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrL[XJKSzVyPUG1MlEhdk1? MoDMV2FPT0WU
CHL-1 M1TIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYn2dIx3UUN3ME2xOU41PSCwTR?= NGDVOHRUSU6JRWK=
VMRC-RCZ NH3HXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXSzcWN[UUN3ME2xOU43OyCwTR?= M{i3cXNCVkeHUh?=
HH NEXjdGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF3Lkegcm0> MkDuV2FPT0WU
NUGC-3 NV\RTldIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\kPWlEPTB;MU[uN|Qhdk1? NXv2WYh{W0GQR1XS
EGI-1 Mn3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXlTWM2OD1zNj60N{BvVQ>? NV\JcGJNW0GQR1XS
OS-RC-2 NHziXIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF4LkS3JI5O NF3aO4RUSU6JRWK=
MOLT-16 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF5LkG1JI5O MonkV2FPT0WU
NCI-H209 MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3nd4FMUUN3ME2xO{4zQSCwTR?= NWHLcFlJW0GQR1XS
697 M3nTbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXwTWM2OD1zNz60N{BvVQ>? M4P3dXNCVkeHUh?=
D-56MG MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPUZoVpUUN3ME2xO{43QSCwTR?= NXO0enZ2W0GQR1XS
VA-ES-BJ M{fnRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnJTWM2OD1zNz64N{BvVQ>? M1zVfHNCVkeHUh?=
EW-16 NUfkNohDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHDNJJKSzVyPUG4MlA1KG6P M4TJZnNCVkeHUh?=
HGC-27 NYDuSWVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz2N4ZuUUN3ME2xPE4xPiCwTR?= NHzxdZNUSU6JRWK=
ES7 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPDNmpKSzVyPUG4MlA6KG6P NHLGfJdUSU6JRWK=
HuH-7 M1LSdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DkemlEPTB;MUiuOEBvVQ>? M1fpWnNCVkeHUh?=
BCPAP MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTzTHRKSzVyPUG4MlY2KG6P M{HvS3NCVkeHUh?=
SW1710 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojITWM2OD1zOD63NkBvVQ>? NUPPeFV7W0GQR1XS
IST-MEL1 NYHuZ3ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3GwSmlEPTB;MUiuO|chdk1? NXfYO2ZwW0GQR1XS
SF295 M{G4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rGfGlEPTB;MUiuPVMhdk1? MU\TRW5ITVJ?
RPMI-7951 NIfEOYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i3SWlEPTB;MUmuNlghdk1? NX7PXnB1W0GQR1XS
SF126 M1T0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTF7LkSxJI5O NWHRWFh2W0GQR1XS
GAMG NUXHVZBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvSRnFpUUN3ME2xPU41QCCwTR?= MYHTRW5ITVJ?
KNS-81-FD NYDaO4NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX75coNLUUN3ME2xPU42PCCwTR?= MVvTRW5ITVJ?
RT-112 MkP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmT0TWM2OD1zOT62OkBvVQ>? M2\3WnNCVkeHUh?=
DEL MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X3cGlEPTB;MkCuOFkhdk1? M3;FZXNCVkeHUh?=
CGTH-W-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXpT|ZKSzVyPUKwMlY{KG6P M4DQXXNCVkeHUh?=
HOS NF\3Xm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXyzfXlrUUN3ME2yNU4xPiCwTR?= NWLUdIFmW0GQR1XS
ES4 NWXMNHY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH2bo5iUUN3ME2yNU4xQCCwTR?= NXnTbm03W0GQR1XS
RXF393 M3\lcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJzLkS1JI5O NGS5XHBUSU6JRWK=
NCI-H2030 M3PDXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTJzLkWyJI5O M{W1Z3NCVkeHUh?=
YH-13 Mn7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXGTWM2OD1{MT64PEBvVQ>? MXjTRW5ITVJ?
HT-1080 NIftNGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK0TWM2OD1{MT65N{BvVQ>? NWXIW|dpW0GQR1XS
NCI-SNU-1 M1zs[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlroTWM2OD1{MT65OUBvVQ>? NHzzUmxUSU6JRWK=
G-402 NVi1W3VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\jeWlEPTB;MkKuNVYhdk1? MmmwV2FPT0WU
786-0 NUHZXFc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvGUHVKSzVyPUKyMlI6KG6P NIX3SFNUSU6JRWK=
ME-180 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJ{LkSzJI5O NFXhVFJUSU6JRWK=
NB69 MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ{LkWzJI5O M1rvb3NCVkeHUh?=
J-RT3-T3-5 M{DlfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTWbYZiUUN3ME2yNk46PiCwTR?= MnjKV2FPT0WU
TGBC1TKB MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TZN2lEPTB;MkOuNFUhdk1? NGXOeGRUSU6JRWK=
SW780 NFTjbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3WzSGlEPTB;MkOuNVMhdk1? NX\UZ2RCW0GQR1XS
MG-63 Mo\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3THUGlEPTB;MkOuOFUhdk1? M2H0bHNCVkeHUh?=
BV-173 NVLEXGRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\LTWM2OD1{Mz64O{BvVQ>? NFvkN2lUSU6JRWK=
CAL-51 NULkTnJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfwXYpKSzVyPUKzMlg6KG6P M2LXVXNCVkeHUh?=
A375 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nhemlEPTB;MkOuPVMhdk1? NYDic3ZCW0GQR1XS
MEL-HO NWflWJJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HWd2lEPTB;MkSuNFQhdk1? MXvTRW5ITVJ?
EFO-27 M1[2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV70fmZGUUN3ME2yOE4{OyCwTR?= NF7OeHFUSU6JRWK=
Hs-578-T Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJ2LkW4JI5O NFjuRVdUSU6JRWK=
NBsusSR NGfCWG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqyZ4VKSzVyPUK0MlYhdk1? MX\TRW5ITVJ?
CTB-1 Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;VTWM2OD1{ND62O{BvVQ>? MWrTRW5ITVJ?
FTC-133 M3ntXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrtTWM2OD1{NT6xJI5O M2mxT3NCVkeHUh?=
MOLT-4 Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFr1fIVKSzVyPUK1MlEzKG6P MYTTRW5ITVJ?
HO-1-N-1 NXmzeHhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\LPHhyUUN3ME2yOU4yPSCwTR?= M3X3UXNCVkeHUh?=
ES3 NFL6eHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3v5TGlEPTB;MkWuNlIhdk1? MVTTRW5ITVJ?
TI-73 Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVflTJNzUUN3ME2yOU4zQCCwTR?= MonPV2FPT0WU
MPP-89 NIXzeXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PxNmlEPTB;MkWuN|Ihdk1? NUDtd2o4W0GQR1XS
KYSE-150 NETlPHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XZbWlEPTB;MkWuPFkhdk1? NGSyNoRUSU6JRWK=
LXF-289 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\6VGlEPTB;Mk[uNFQhdk1? NEjlOY1USU6JRWK=
SK-LU-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\LTWM2OD1{Nj6xO{BvVQ>? MUnTRW5ITVJ?
HOP-92 NW[wOnVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jkb2lEPTB;Mk[uOFghdk1? M1jzc3NCVkeHUh?=
HuO9 MonmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLtOXRUUUN3ME2yOk44PiCwTR?= MX7TRW5ITVJ?
SW962 MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTKTWM2OD1{Nj63OkBvVQ>? MoPHV2FPT0WU
RS4-11 NIPBW2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDhTIlKSzVyPUK2MlkyKG6P NF;jR4hUSU6JRWK=
NCI-H292 NGPH[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPyOodHUUN3ME2yO{BvVQ>? MoX6V2FPT0WU
DB NFG1R2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmO5TWM2OD1{Nz6zOkBvVQ>? MYnTRW5ITVJ?
SW1088 MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPZTWM2OD1{OD6yPUBvVQ>? NWjsTlNYW0GQR1XS
A204 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFmzVWVKSzVyPUK4MlQ4KG6P NWjKS4pOW0GQR1XS
A3-KAW MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NID4b5dKSzVyPUK4MlY1KG6P M1PKcHNCVkeHUh?=
MV-4-11 M2nI[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJ6Lkegcm0> NI[w[mdUSU6JRWK=
ES1 NEfENY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFO5N29KSzVyPUK4Mlg1KG6P M{PqfXNCVkeHUh?=
ONS-76 M{ToeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJ7LkC1JI5O M2XVV3NCVkeHUh?=
D-263MG M3XhVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHoZXRKSzVyPUK5MlM2KG6P Mo[2V2FPT0WU
U-2-OS NVv5WpJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTnXGVKSzVyPUK5MlUhdk1? MYjTRW5ITVJ?
T98G NWLsWnM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nySWlEPTB;MkmuPFghdk1? NIjkXIZUSU6JRWK=
GI-ME-N Mo\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nF[mlEPTB;MkmuPVEhdk1? MUHTRW5ITVJ?
BHT-101 NWDGR4xzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O1SWlEPTB;M{CuNFUhdk1? MXXTRW5ITVJ?
NOS-1 M{S4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLOTWM2OD1|MD6xNkBvVQ>? MX7TRW5ITVJ?
AsPC-1 NUXKbGhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTNyLkKgcm0> MXLTRW5ITVJ?
QIMR-WIL MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W3V2lEPTB;M{CuOkBvVQ>? NWHmOW5WW0GQR1XS
JVM-3 NV;oNVB{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjsVIc3UUN3ME2zNE45OyCwTR?= NXztOYY2W0GQR1XS
KU-19-19 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfo[Xk5UUN3ME2zNU4yOyCwTR?= M4ry[nNCVkeHUh?=
OVCAR-8 NV;HNlVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTNzLkK2JI5O MYfTRW5ITVJ?
BEN NGfvN|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7lNFJKSzVyPUOxMlY{KG6P MkjUV2FPT0WU
BE-13 NYrpZ4VoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\1UFczUUN3ME2zNU45OiCwTR?= NFjFT2NUSU6JRWK=
EW-18 NUnD[Jg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW2e2hKSzVyPUOxMlg3KG6P M4\HVHNCVkeHUh?=
ECC10 MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H4d2lEPTB;M{GuPVUhdk1? MoXGV2FPT0WU
CTV-1 NGPoc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTN{LkiyJI5O M1nNR3NCVkeHUh?=
COLO-800 MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\HVolLUUN3ME2zNk46OiCwTR?= MmT1V2FPT0WU
A2058 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO5VXVEUUN3ME2zN{4zPSCwTR?= NUfueppnW0GQR1XS
VM-CUB-1 M2HIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PwbGlEPTB;M{OuOFMhdk1? M1\PPXNCVkeHUh?=
Ca9-22 NEPqeoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTN|LkW1JI5O MXLTRW5ITVJ?
COLO-684 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX3TWM2OD1|Mz61PEBvVQ>? M13HUXNCVkeHUh?=
RPMI-8226 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zCc2lEPTB;M{OuPFIhdk1? MoS2V2FPT0WU
SK-NEP-1 MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTN2LkG1JI5O NGP5VZpUSU6JRWK=
Becker MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2m3WmlEPTB;M{SuNlEhdk1? MUHTRW5ITVJ?
NCI-H28 M1LBdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrFTWM2OD1|ND60OEBvVQ>? NX;z[nFWW0GQR1XS
CAL-120 NHLxe3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O0OGlEPTB;M{SuO|Ihdk1? NV31SnliW0GQR1XS
MDA-MB-157 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTN3LkSxJI5O M4GyUnNCVkeHUh?=
OVCAR-5 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi1bHJkUUN3ME2zOU41PyCwTR?= NIjWNGJUSU6JRWK=
LAMA-84 Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnoTWM2OD1|NT64O{BvVQ>? M3K0VXNCVkeHUh?=
CAKI-1 MmHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTtfmJKSzVyPUO2MlQ{KG6P NWj6Voc{W0GQR1XS
Daoy NWf2N2M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTN4Lkegcm0> M37mZnNCVkeHUh?=
CAL-62 MlWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\ye2lEPTB;M{[uPFYhdk1? M2jLVHNCVkeHUh?=
8-MG-BA Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXjOINDUUN3ME2zO{4zPSCwTR?= NIDzbIZUSU6JRWK=
8505C M12zZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NICzZ2pKSzVyPUO3MlUyKG6P Mn\uV2FPT0WU
LNCaP-Clone-FGC NWfuenlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLLTWM2OD1|Nz61PUBvVQ>? MnfqV2FPT0WU
CAL-39 NHrDUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnhTWM2OD1|Nz65JI5O M1q2ZXNCVkeHUh?=
MN-60 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HFRWlEPTB;M{euPVYhdk1? Mn7NV2FPT0WU
RKO MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTN6LkOzJI5O NH25T29USU6JRWK=
U251 M1zQUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjPXVZ7UUN3ME2zPE41OyCwTR?= NE\vbVNUSU6JRWK=
SJSA-1 MlnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXLUplKSzVyPUO4MlU1KG6P MVnTRW5ITVJ?
CAL-12T NX;LToE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTN6Lk[gcm0> Mlm0V2FPT0WU
HCC1419 NW[xdHZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTN6LkexJI5O NYPaTJZkW0GQR1XS
CO-314 M1q1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rDdGlEPTB;M{iuO|Qhdk1? NHLM[2xUSU6JRWK=
LB1047-RCC M3fRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7ITWM2OD1|OD64NUBvVQ>? NInBe2ZUSU6JRWK=
A101D NUHKdY1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3iw[WlEPTB;M{iuPVchdk1? Mmi1V2FPT0WU
MDA-MB-175-VII Mlz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T0OWlEPTB;M{muOVEhdk1? NH7GW41USU6JRWK=
MZ2-MEL NIj4fWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3ye|Z6UUN3ME2zPU43PiCwTR?= MU\TRW5ITVJ?
NB5 MkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTRyLk[0JI5O NUfYcGx5W0GQR1XS
G-401 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\sdGlEPTB;NECuPFIhdk1? M4j4UnNCVkeHUh?=
HT NHThfHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTRzLkCyJI5O MYnTRW5ITVJ?
8305C M2KwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTRzLki3JI5O M1;xXHNCVkeHUh?=
BHY MmXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvR[Zc4UUN3ME20Nk44OiCwTR?= M{HnOnNCVkeHUh?=
NTERA-S-cl-D1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3oTWM2OD12MzDuUS=> M1XrUHNCVkeHUh?=
T-24 MlL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvjTWM2OD12Mz64N{BvVQ>? Ml2yV2FPT0WU
EPLC-272H MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR2LkO5JI5O NIT1RXFUSU6JRWK=
PSN1 M2L1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFThcZpKSzVyPUS0MlQhdk1? M2Dl[HNCVkeHUh?=
NCI-H2452 MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTR2LkW4JI5O MmDtV2FPT0WU
KS-1 M{Psd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TRd2lEPTB;NESuOlYhdk1? M2LSdHNCVkeHUh?=
HD-MY-Z NWHmbJZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTR2LkmyJI5O MmrUV2FPT0WU
KNS-62 MlqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG3OI5KSzVyPUS1MlM5KG6P MkT4V2FPT0WU
NOMO-1 MnTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTR3Lki3JI5O Mkf6V2FPT0WU
SK-HEP-1 NYrm[IprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHVTWM2OD12Nj6wOEBvVQ>? NYqyZ4F[W0GQR1XS
IGR-1 MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTR4LkGzJI5O MXPTRW5ITVJ?
KYSE-180 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTR4LkG3JI5O NW\n[FQ6W0GQR1XS
EW-22 NGnxNGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonSTWM2OD12Nj6yJI5O NVvDPVBEW0GQR1XS
NCI-H1355 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzDTWM2OD12Nj6zOEBvVQ>? NVPW[4tnW0GQR1XS
DOHH-2 NEPvO|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTR4LkO3JI5O MY\TRW5ITVJ?
A4-Fuk MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTR4LkWyJI5O MoTRV2FPT0WU
PC-14 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37HUmlEPTB;NE[uOVchdk1? MX;TRW5ITVJ?
TE-5 NHHVbJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHFTWM2OD12Nj64OEBvVQ>? M2TuWXNCVkeHUh?=
LB996-RCC MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTR5LkG5JI5O M4\LS3NCVkeHUh?=
NCI-H1623 NILN[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTR5Lke2JI5O NH7BOZVUSU6JRWK=
NCI-H1155 M1HwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfFSpV{UUN3ME20PE4{OiCwTR?= M{jZWXNCVkeHUh?=
LoVo NW\2XmNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom0TWM2OD12OD60JI5O NH7vN2JUSU6JRWK=
MCF7 NXvo[442T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXJNYpKSzVyPUS4MlU5KG6P NEHXZpJUSU6JRWK=
AGS NF;lZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXBTWM2OD12OD63O{BvVQ>? MWPTRW5ITVJ?
PFSK-1 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL1[Yp1UUN3ME20PU4xPiCwTR?= MXfTRW5ITVJ?
22RV1 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTR7LkC5JI5O NY\jVFN1W0GQR1XS
COR-L23 MlXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPw[lNKSzVyPUS5MlE3KG6P NHfsWYlUSU6JRWK=
D-283MED NX;VTolsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rwNmlEPTB;NEmuOlEhdk1? MXzTRW5ITVJ?
SW982 NV74Z5o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknFTWM2OD12OT65NUBvVQ>? NIPIO5ZUSU6JRWK=
SW620 NFrqV|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW1TWM2OD13MD6zOkBvVQ>? NFrEOJRUSU6JRWK=
KYSE-140 M4XJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjDdIxrUUN3ME21NE42PSCwTR?= MmnXV2FPT0WU
GCIY M1\TUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\xd|BKSzVyPUWwMlY4KG6P NUDqeXRoW0GQR1XS
MHH-ESS-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nW[2lEPTB;NUGuPVUhdk1? MVfTRW5ITVJ?
D-423MG NFvhe4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTV{LkC4JI5O MVrTRW5ITVJ?
SF539 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHiVJhKSzVyPUWyMlM2KG6P NYe0O3FWW0GQR1XS
RPMI-2650 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3sSnBKSzVyPUWyMlY6KG6P MorIV2FPT0WU
GR-ST Mmf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP0TWM2OD13Mj64O{BvVQ>? NVrDeHV5W0GQR1XS
YKG-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjHUFd[UUN3ME21N{BvVQ>? MofkV2FPT0WU
SK-MES-1 MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3WTWM2OD13Mz6yOkBvVQ>? M{i3fHNCVkeHUh?=
HLE MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTV|LkS3JI5O Mmi3V2FPT0WU
RVH-421 M2OyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PKOmlEPTB;NUOuOlchdk1? MmLmV2FPT0WU
C32 MoHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLYbIV4UUN3ME21N{45OyCwTR?= NUPuO3ZsW0GQR1XS
GB-1 MnzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFziV4NKSzVyPUW0MlIhdk1? NW[4bIFYW0GQR1XS
SNB75 M37Jd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPyTWM2OD13ND6yOkBvVQ>? NIrQfmtUSU6JRWK=
EM-2 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLmd5ZKSzVyPUW0MlQhdk1? MXnTRW5ITVJ?
RH-1 MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTV2Lkegcm0> M{K3ZXNCVkeHUh?=
NKM-1 NGfJVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjXeo5KSzVyPUW0MlgyKG6P NELBTJlUSU6JRWK=
NCI-H2405 M2S1S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rWdGlEPTB;NUSuPFghdk1? MV;TRW5ITVJ?
KYSE-450 M37iV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTV3LkG2JI5O M{L2ZXNCVkeHUh?=
A704 NX\hfXl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HpUWlEPTB;NUWuOVkhdk1? NVmyfIc3W0GQR1XS
HAL-01 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHSeWE5UUN3ME21OU45OyCwTR?= NFP0b3BUSU6JRWK=
TE-11 NXTXO4p6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T2TGlEPTB;NUWuPVkhdk1? MU\TRW5ITVJ?
DOK M4DofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTV4LkCyJI5O Mn;qV2FPT0WU
KY821 NXXHR3pzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvmZ|RKSzVyPUW2MlIhdk1? MX3TRW5ITVJ?
KGN MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LTNWlEPTB;NU[uN|Ihdk1? MnrQV2FPT0WU
MC116 NY[1NHQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj2SJZKSzVyPUW3Mlghdk1? NH3SeW9USU6JRWK=
PANC-08-13 M2Tte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnsVIhKSzVyPUW4MlAyKG6P NX2xNohQW0GQR1XS
KE-37 M4DG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrLXoRKSzVyPUW4Mlc4KG6P NETCXnFUSU6JRWK=
KYSE-410 Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\TeWlEPTB;NUmuOFchdk1? Ml\BV2FPT0WU
RO82-W-1 M3PXNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnJSFdKSzVyPUW5Mlkhdk1? NWjaUWtmW0GQR1XS
M14 NGLlO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTZyLkC0JI5O MYnTRW5ITVJ?
GI-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnryTWM2OD14MD6zJI5O NFnUcXVUSU6JRWK=
ML-2 M4nLemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXWTWM2OD14MD62NkBvVQ>? M3zqb3NCVkeHUh?=
BFTC-905 Mlr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq4TWM2OD14MD62OUBvVQ>? Mn7XV2FPT0WU
DMS-273 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[5TWM2OD14MD64O{BvVQ>? MWPTRW5ITVJ?
MDA-MB-361 MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj0RpJKSzVyPU[xJI5O NWPMU29iW0GQR1XS
MSTO-211H NHTQOWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fuXGlEPTB;NkOuOVEhdk1? NIDIZYJUSU6JRWK=
MEG-01 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHQS4liUUN3ME22N{42OiCwTR?= NVq0ZVREW0GQR1XS
M059J NE\CS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[5TWM2OD14Mz61PEBvVQ>? NXruVGxbW0GQR1XS
LN-405 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHyzbZVKSzVyPU[zMlg2KG6P M2HkdHNCVkeHUh?=
NCI-H1581 NFG4VpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPycJRxUUN3ME22OE4xOyCwTR?= MXLTRW5ITVJ?
TCCSUP MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fBeWlEPTB;NkSuOVMhdk1? MmDQV2FPT0WU
SW872 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzCTpNPUUN3ME22OE42PyCwTR?= Mo[zV2FPT0WU
KYSE-510 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;GXG9KSzVyPU[1Mlc2KG6P MmDYV2FPT0WU
NCI-H1792 M2HEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDxTWM2OD14Nj6xOUBvVQ>? M4T3W3NCVkeHUh?=
SW13 NXuxOpFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTTTWM2OD14Nj61JI5O M{\qT3NCVkeHUh?=
TE-8 MkO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;zTGlEPTB;Nk[uOVIhdk1? Mm\pV2FPT0WU
SCH NFnBWINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XHb2lEPTB;NkeuNUBvVQ>? MYXTRW5ITVJ?
NEC8 NWrEfnR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoW3TWM2OD14Nz6yOEBvVQ>? M1L3NXNCVkeHUh?=
HuO-3N1 M3u2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjVSHBKSzVyPU[3MlMyKG6P MW\TRW5ITVJ?
EFM-19 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnKSIRKSzVyPU[3MlUhdk1? MYPTRW5ITVJ?
HEC-1 NXX4WVJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS4TWM2OD14Nz61NkBvVQ>? M1PPRXNCVkeHUh?=
T47D NUHYOGtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTZ5Lki3JI5O NF\KepdUSU6JRWK=
SNU-423 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXQWoxOUUN3ME22O{46QCCwTR?= NF7QOHdUSU6JRWK=
WM-115 M2TKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTZ6LkG0JI5O NY\zN5VtW0GQR1XS
CaR-1 MnjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTZ6LkK1JI5O MWjTRW5ITVJ?
KU812 NGfmNZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TNTGlEPTB;NkiuOlkhdk1? MWPTRW5ITVJ?
AM-38 NWXiNZlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nrSmlEPTB;NkmuN|Ehdk1? NHn6UoFUSU6JRWK=
KOSC-2 NUOy[4JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrM[oRbUUN3ME22PU46PyCwTR?= NFLzcXRUSU6JRWK=
MC-IXC NUfQSZhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTdyLkC4JI5O MUjTRW5ITVJ?
SCC-4 NIS1TWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHQTWM2OD15MT6zPEBvVQ>? M3T6WHNCVkeHUh?=
Calu-3 M1vQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe1WIFHUUN3ME23NU46QCCwTR?= MoLnV2FPT0WU
RPMI-8866 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jVSGlEPTB;N{KuPFIhdk1? MVPTRW5ITVJ?
OVCAR-4 M4Sxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj1TWM2OD15Mz6zOkBvVQ>? MUTTRW5ITVJ?
OAW-42 NH\GS5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljNTWM2OD15Mz6zPUBvVQ>? MkXMV2FPT0WU
ATN-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTd|Lki3JI5O NH7w[GlUSU6JRWK=
CHP-212 NVXpR29ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTd2Lkm1JI5O Ml\YV2FPT0WU
C2BBe1 NXfXcnJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;iTWM2OD15NT6wN{BvVQ>? NV\tSoE6W0GQR1XS
A498 NYr0RnRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fwR2lEPTB;N{WuNVUhdk1? M2\NW3NCVkeHUh?=
SH-4 NX;2RXZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;hbmlEPTB;N{WuNlEhdk1? MVTTRW5ITVJ?
SNU-449 NUXvT2RyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTGXnNtUUN3ME23OU44QSCwTR?= NEDPR2RUSU6JRWK=
RD M4fNc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXLc5hIUUN3ME23OU45PiCwTR?= NULEcZIzW0GQR1XS
PANC-03-27 M33hOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorITWM2OD15Nj6yOUBvVQ>? NYDifIlwW0GQR1XS
S-117 M121bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorqTWM2OD15Nj6yO{BvVQ>? Mn3UV2FPT0WU
SK-MEL-2 M17vdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnjZ|FjUUN3ME23Ok44PSCwTR?= NWXkeHdSW0GQR1XS
LK-2 NFzpflZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTd5LkC1JI5O MV3TRW5ITVJ?
CP50-MEL-B MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTd5LkSgcm0> MlLoV2FPT0WU
647-V MonhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\URmlEPTB;N{iuNFchdk1? MnPlV2FPT0WU
LU-134-A MmHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLZbItJUUN3ME23PU4xOyCwTR?= MlnvV2FPT0WU
5637 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHvTXlKSzVyPUe5MlI{KG6P Mn;DV2FPT0WU
NCI-H1437 NFLxRmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGyUYtNUUN3ME24NE42KG6P MmDGV2FPT0WU
NCI-H460 M4XDeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPxO2NrUUN3ME24NU4zOyCwTR?= Mlr5V2FPT0WU
BxPC-3 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHX1cFdKSzVyPUixMlQ3KG6P NXXqXHBzW0GQR1XS
CAN MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLUTWRKSzVyPUixMlg1KG6P M3zJUnNCVkeHUh?=
KINGS-1 NYnGd2E{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LPdWlEPTB;OEKuN|Ihdk1? NUjvRoFQW0GQR1XS
OCUB-M MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHMTWM2OD16Mj60NUBvVQ>? NHe3XJlUSU6JRWK=
KALS-1 MnLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2e0V2lEPTB;OEKuOVQhdk1? M1HNUnNCVkeHUh?=
OCI-AML2 M{PnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTh{Lk[xJI5O M1PuSHNCVkeHUh?=
A253 NYm3R2xiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj6TWM2OD16Mj62OUBvVQ>? NGTFXZNUSU6JRWK=
LCLC-97TM1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1uzWGlEPTB;OEKuPFYhdk1? MX\TRW5ITVJ?
NCI-H520 M2ThbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTh|LkC2JI5O MVXTRW5ITVJ?
P30-OHK NIjE[XBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTh|LkWgcm0> NFnkOIlUSU6JRWK=
SBC-5 M4jEb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTh|LkWyJI5O MVnTRW5ITVJ?
HCE-T M{XK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUewXZpWUUN3ME24N{44PCCwTR?= Mk\pV2FPT0WU
JEG-3 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H5bWlEPTB;OESuNUBvVQ>? NVLZOolkW0GQR1XS
KG-1 NUK5WYNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;3NWlEPTB;OESuNlQhdk1? Ml3vV2FPT0WU
MIA-PaCa-2 M363N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;jTWM2OD16ND61OEBvVQ>? M1\JcXNCVkeHUh?=
CAL-33 NFW3NVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTSTWM2OD16NT6wPEBvVQ>? MWjTRW5ITVJ?
639-V MoTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HHcWlEPTB;OEWuOFIhdk1? NUfDdIVGW0GQR1XS
NCI-H1048 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;RcXFHUUN3ME24Ok4{OSCwTR?= MVLTRW5ITVJ?
NCI-H1573 NYLUPGJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MliwTWM2OD16Nz60PEBvVQ>? M1LH[3NCVkeHUh?=
NCI-H2228 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofSTWM2OD16OD6yOkBvVQ>? M3m3UHNCVkeHUh?=
NB14 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTtV3hzUUN3ME24PE4{KG6P NFPKfJdUSU6JRWK=
SCC-25 M2fFO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjzfpFKSzVyPUi5MlgzKG6P M1zPVnNCVkeHUh?=
A431 Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTnS3FqUUN3ME24PU46PyCwTR?= Mn[1V2FPT0WU
SN12C MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\2XGlEPTB;OUCuOlIhdk1? MVXTRW5ITVJ?
HuCCT1 Ml\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XNVWlEPTB;OUCuO|Yhdk1? M2XtTHNCVkeHUh?=
LS-123 M3LWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\Qd2hKSzVyPUmyMlE5KG6P NFXjfm9USU6JRWK=
CAL-85-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTl{LkS4JI5O NH\5enBUSU6JRWK=
ES6 NWrsZpRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r4NmlEPTB;OUKuPFMhdk1? MVPTRW5ITVJ?
NCI-H650 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nPV2lEPTB;OUSuNFkhdk1? MVzTRW5ITVJ?
NCI-H446 M3vG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PPcWlEPTB;OUWuNVIhdk1? NUn0T3VMW0GQR1XS
EW-13 NEXMVIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTMTWM2OD17NT63OUBvVQ>? M1vXenNCVkeHUh?=
HSC-2 NY\ZN4ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTl3Lki5JI5O MWDTRW5ITVJ?
U031 MknMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXyT5VKSzVyPUm2Mlc{KG6P NYfrPXZsW0GQR1XS
EW-11 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13p[mlEPTB;OU[uPFghdk1? NYPoSZU1W0GQR1XS
GAK Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;vSWlEPTB;OUiuPVMhdk1? NX74RXdiW0GQR1XS
SK-OV-3 MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\weWlEPTB;MUCwMlA4KG6P MYXTRW5ITVJ?
OMC-1 NH72XoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjNUFhlUUN3ME2xNFAvOThibl2= M1\SZ3NCVkeHUh?=
TK10 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTFyMD6yNUBvVQ>? MXPTRW5ITVJ?
EKVX MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTiTWM2OD1zMECuOkBvVQ>? NWnyW21WW0GQR1XS
Detroit562 M{n3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTDTWM2OD1zMEKuNVchdk1? MorHV2FPT0WU
SF268 NYX0SnlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1niTWlEPTB;MUCyMlM1KG6P M3vyS3NCVkeHUh?=
SNU-387 M2nTSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHEeIdjUUN3ME2xNFQvOTdibl2= NXTRe2F3W0GQR1XS
MDA-MB-231 M1fw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\4TWM2OD1zMEWuNFYhdk1? MX3TRW5ITVJ?
NCI-H1563 NGO1OY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXQdolKSzVyPUGwOU4yQCCwTR?= MX;TRW5ITVJ?
D-502MG NU\nN3FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTaVmJwUUN3ME2xNFUvPyCwTR?= NF\RUJJUSU6JRWK=
A2780 NID3SZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvMOVNUUUN3ME2xNFYvPDdibl2= MV7TRW5ITVJ?
IA-LM NXHx[o1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLiNWpKSzVyPUGwO{42OSCwTR?= NVzmWHlDW0GQR1XS
D-392MG Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDjV3dKSzVyPUGwO{42PCCwTR?= M{Dhe3NCVkeHUh?=
MS-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;mTWM2OD1zMEeuO|Ehdk1? M3rifHNCVkeHUh?=
SW1990 NG\TTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:5TWM2OD1zMEiuOVQhdk1? NUS2Xm1SW0GQR1XS
HEL NXz4eIdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjIN21KSzVyPUGwPU4zQSCwTR?= MVvTRW5ITVJ?
SW1573 NF\4TWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFyOT6zNUBvVQ>? NYTKfXJjW0GQR1XS
SW1783 NFzlOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFzMD6yNkBvVQ>? NH3ae5lUSU6JRWK=
COLO-680N Moj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPCRmsxUUN3ME2xNVAvPzZibl2= NH;XNmNUSU6JRWK=
NCI-N87 Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH0OmhKSzVyPUGxNU4xPCCwTR?= MWDTRW5ITVJ?
SK-MEL-28 NXvCT3dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TCT2lEPTB;MUGxMlU2KG6P Mn32V2FPT0WU
BT-20 MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvueoxvUUN3ME2xNVIvODFibl2= NVrCbZo1W0GQR1XS
NCI-H1648 NHy4cXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTFzMzDuUS=> MnTFV2FPT0WU
no-11 NHLDe2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\3RoY3UUN3ME2xNVMvOjhibl2= NETSWYpUSU6JRWK=
MOLT-13 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzYTWM2OD1zMUOuOFQhdk1? M3nm[nNCVkeHUh?=
NCI-H2170 NHn2cmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnV[XdqUUN3ME2xNVQvPTFibl2= MUTTRW5ITVJ?
HTC-C3 M3XtOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFzNj64OUBvVQ>? NHLNOZBUSU6JRWK=
LU-99A MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfkTWM2OD1zMUeuNlEhdk1? NGC5OXhUSU6JRWK=
HCC2998 NX2wZ5lHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jFfGlEPTB;MUG3MlkzKG6P M3KyTXNCVkeHUh?=
NB13 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPvUHFxUUN3ME2xNVcvQTlibl2= MlnjV2FPT0WU
GT3TKB NV71VoNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfBT29KSzVyPUGxPE4xQCCwTR?= NVTPUHQyW0GQR1XS
BT-549 NHvubVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTDOXJsUUN3ME2xNVgvQTVibl2= Mly3V2FPT0WU
NCI-H747 NWrOXIJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17TdmlEPTB;MUG5MlM1KG6P NXHh[4t[W0GQR1XS
EW-1 M175Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTF{MD6yJI5O MWTTRW5ITVJ?
LB831-BLC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrLUY1KSzVyPUGyNE43OyCwTR?= NWn6fJhRW0GQR1XS
NMC-G1 NE\TXGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF{MT6xNUBvVQ>? NXzYfHJ6W0GQR1XS
COLO-679 Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrjbHBKSzVyPUGyNk4yPSCwTR?= M2W1d3NCVkeHUh?=
HL-60 NFzyVXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTF{Mz6xJI5O NGTjSW1USU6JRWK=
MKN7 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn5XoVKSzVyPUGyN{45OyCwTR?= MkDlV2FPT0WU
RERF-LC-MS MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33DUmlEPTB;MUK0MlMyKG6P MonGV2FPT0WU
DMS-114 MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zQWWlEPTB;MUK1MlA6KG6P NH\qcY1USU6JRWK=
HuP-T4 MoTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\iTWM2OD1zMk[uPVchdk1? NED3Z2FUSU6JRWK=
HCC2157 NVvMOIVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXqdZBKSzVyPUGyO{42KG6P MVHTRW5ITVJ?
SKG-IIIa MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjmTWM2OD1zMkiuPEBvVQ>? M3TONnNCVkeHUh?=
HCT-116 M3WxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\PcXhKUUN3ME2xN|AvPjRibl2= NWi2[5R[W0GQR1XS
BB30-HNC M4\zR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml71TWM2OD1zM{CuO|ghdk1? MVTTRW5ITVJ?
KYSE-270 NWPndoJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHsZ|hwUUN3ME2xN|AvQDhibl2= NXL1Om5QW0GQR1XS
MFM-223 NW\Y[pJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fCc2lEPTB;MUOxMlUyKG6P MmjQV2FPT0WU
NH-12 NWTs[IR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTF|Mj65PUBvVQ>? NFjaTHBUSU6JRWK=
U-118-MG M1XYU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rkeWlEPTB;MUOzMlYzKG6P MnLFV2FPT0WU
ESS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK3RpE3UUN3ME2xN|UvOThibl2= NE[ydldUSU6JRWK=
D-247MG NVLybIVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTF|NT6yNUBvVQ>? NFXGZppUSU6JRWK=
IGROV-1 M4W5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrETWM2OD1zM{WuO|Yhdk1? MUjTRW5ITVJ?
C-33-A NX[3ZXBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\M[2lEPTB;MUO1Mlk4KG6P M1H4dHNCVkeHUh?=
NCI-H1693 M4HlUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTJTWM2OD1zM{[uNVIhdk1? M1n0SXNCVkeHUh?=
MLMA NWPtfo81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[xTWM2OD1zM{[uOVghdk1? MVjTRW5ITVJ?
SK-N-AS M2D5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TOfGlEPTB;MUO3MlE4KG6P MVXTRW5ITVJ?
NCI-H1755 NVXnT3g6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\XTWM2OD1zM{iuPFUhdk1? MmDtV2FPT0WU
CHP-134 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv5WJJGUUN3ME2xN|kvPTVibl2= NVP5W2tJW0GQR1XS
LS-513 NVzZV5VWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTH[GNKSzVyPUG0NE46OSCyTR?= MUPTRW5ITVJ?
TE-12 M3\5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi1SnF[UUN3ME2xOFAvQTNibl2= M4f1OHNCVkeHUh?=
KNS-42 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF2ND6zJI5O M4fVW3NCVkeHUh?=
SJRH30 M3fSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jmWmlEPTB;MUS0MlQ1KG6P MWfTRW5ITVJ?
NCI-H1092 MnfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;zdGlEPTB;MUS0MlUzKG6P M3TucXNCVkeHUh?=
H-EMC-SS NF63[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC3WINKSzVyPUG0Ok45OSCwTR?= NETFXlRUSU6JRWK=
SK-MEL-3 NFm1V3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnToTWM2OD1zNEeuOVUhdk1? MlzRV2FPT0WU
SK-N-FI MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjCZYRHUUN3ME2xOFcvPTlibl2= NXXyemI6W0GQR1XS
NCI-H2126 NWXGXHRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfUWVNKSzVyPUG0PE4yPSCwTR?= NUHxUVA{W0GQR1XS
NCI-H1299 NH\l[mhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULqdIFIUUN3ME2xOVAvOjJibl2= MUPTRW5ITVJ?
CFPAC-1 M3TqOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF3MD62OkBvVQ>? NH;6WllUSU6JRWK=
NCI-H661 NUDwTXJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX1TG1KSzVyPUG1NU4zPiCwTR?= NUP1RXNVW0GQR1XS
KYSE-70 NXTB[ZhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHTbJBUUUN3ME2xOVEvPzlibl2= NXLZV3FpW0GQR1XS
SW900 NIPieGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjTT2RlUUN3ME2xOVQvPjVibl2= MUHTRW5ITVJ?
Ca-Ski NFzKS3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDze5lHUUN3ME2xOVYvOzlibl2= NF\vZnlUSU6JRWK=
HPAF-II M1XVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTzTWM2OD1zNU[uOFchdk1? M4TJfXNCVkeHUh?=
LB2518-MEL MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV25[5QzUUN3ME2xOVcvOSCwTR?= NILrOYVUSU6JRWK=
LC-2-ad MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGCyeohKSzVyPUG1PE43OiCwTR?= NVe5fZdtW0GQR1XS
HCC1806 NUTOfJhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF4Nz64PEBvVQ>? MUnTRW5ITVJ?
UACC-62 NEDueWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj5U|NKSzVyPUG2PE4xQSCwTR?= MlHIV2FPT0WU
KM-H2 NGrIdmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\EPIZKSzVyPUG3NE42QCCwTR?= NIHjR2VUSU6JRWK=
NCI-H2347 MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7CS3R7UUN3ME2xO|IvPzJibl2= MV3TRW5ITVJ?
SCC-15 NEXyOFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7MZZlsUUN3ME2xO|MvPjZibl2= Ml74V2FPT0WU
BB49-HNC NYPYfHFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TaXWlEPTB;MUezMlgyKG6P NFjkW3BUSU6JRWK=
GMS-10 NFHDfmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPuWIlKSzVyPUG3N{46PCCwTR?= MkizV2FPT0WU
NCI-H2052 Mnq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrNfpZKSzVyPUG3OE46KG6P MkjsV2FPT0WU
SW626 NE\KbVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rRV2lEPTB;MUe2MlA3KG6P MnrnV2FPT0WU
MDA-MB-415 M{DkRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTF5Nj62NUBvVQ>? NXnpXZM6W0GQR1XS
Saos-2 M2[zT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzJOG4zUUN3ME2xO|kvOzVibl2= MVnTRW5ITVJ?
DK-MG NVrzdmE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTF6MD6zJI5O NFXXdYFUSU6JRWK=
SNU-C2B NFjjT|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3qNIJlUUN3ME2xPFAvPzNibl2= MUfTRW5ITVJ?
A427 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnJUYRKSzVyPUG4Nk42PyCwTR?= MWLTRW5ITVJ?
KP-N-YS M3v6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nvc2lEPTB;MUi1JI5O MojVV2FPT0WU
J82 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTF6NT6xPEBvVQ>? MmDPV2FPT0WU
LS-411N NWCzUI0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\uTWM2OD1zOEeuNlghdk1? NGPSSHJUSU6JRWK=
HCC1937 M{HI[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;3VFlKSzVyPUG4O{41QSCwTR?= NU\nPINqW0GQR1XS
OE33 M3PRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPsT4pVUUN3ME2xPFgvQTdibl2= NYfWcY1tW0GQR1XS
NB7 M3LPWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[0PWlEPTB;MUi5Mlg6KG6P MkjkV2FPT0WU
SW684 M4f3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHHTWM2OD1zOU[uNVMhdk1? NX;jc2Y{W0GQR1XS
HT-144 M321[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHWwfo5KSzVyPUG5Ok4yPSCwTR?= MmjyV2FPT0WU
SK-MEL-30 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7qcmtxUUN3ME2xPVYvOiCwTR?= NE\qZ4hUSU6JRWK=
DBTRG-05MG NWLaS4t6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTF7OD60O{BvVQ>? NIjSXGJUSU6JRWK=
NCI-H1395 M1zX[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq5TWM2OD1zOUiuPFUhdk1? NFLCWnBUSU6JRWK=
NCI-H2122 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fBZ2lEPTB;MkCwMlU6KG6P MXrTRW5ITVJ?
no-10 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJyMT6wOEBvVQ>? MXHTRW5ITVJ?
SW48 NV;EPJd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnNTWM2OD1{MEGuN|Ehdk1? MnTyV2FPT0WU
NCI-H1650 NH7aT|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvyflZEUUN3ME2yNFQvODFibl2= M{T3TXNCVkeHUh?=
MZ1-PC MlXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXEOJVKSzVyPUKwOU42QCCwTR?= MmWwV2FPT0WU
U-266 NGrFN|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWflcWNiUUN3ME2yNFUvPzlibl2= M1j5fnNCVkeHUh?=
CAS-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJyNz60OEBvVQ>? NWLJNWNnW0GQR1XS
AU565 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLXOIpuUUN3ME2yNVIvQDJibl2= M2D3eHNCVkeHUh?=
UACC-257 MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXJW|FRUUN3ME2yNVMvQTlibl2= NF:3UYRUSU6JRWK=
CAL-27 NGj6TGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m3N2lEPTB;MkG3MlA2KG6P NG\CO29USU6JRWK=
NCI-H23 NX71XXhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL5XplKSzVyPUKxPU4{OyCwTR?= Mo\6V2FPT0WU
TE-6 NGLpT3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT5O2FKSzVyPUKxPU43QCCwTR?= MYnTRW5ITVJ?
TGBC24TKB NGXiRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\OTWM2OD1{MkKuNVchdk1? M4m5PHNCVkeHUh?=
TE-1 MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnRZXhJUUN3ME2yNlIvQDhibl2= NYK0bWdkW0GQR1XS
RCC10RGB M2DZ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkn5TWM2OD1{MkSuNVkhdk1? MXPTRW5ITVJ?
NCI-H596 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITlPHZKSzVyPUKyPE4zOiCwTR?= M{H0PXNCVkeHUh?=
SW954 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJ|Mz64N{BvVQ>? NHHwVo5USU6JRWK=
NCI-H2087 NF\xeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfhTWM2OD1{M{SuOVEhdk1? NY\BUVV3W0GQR1XS
SK-PN-DW NGPBeVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[4TWM2OD1{M{WuNVkhdk1? NFX3T3hUSU6JRWK=
KM12 NGXzWHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnkS|dRUUN3ME2yN|UvPyCwTR?= MkPjV2FPT0WU
BT-474 NVz0NotET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJ|NT63N{BvVQ>? M3[wc3NCVkeHUh?=
IST-MES1 NFTyOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[xW5BKSzVyPUKzOk42PyCwTR?= MYrTRW5ITVJ?
HT-1197 M{\yRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJ|OD6wPUBvVQ>? NHzEWZlUSU6JRWK=
CAL-54 NYfZV4xxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrsTWM2OD1{M{iuOFkhdk1? MkLaV2FPT0WU
NB10 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme5TWM2OD1{NECuNFYhdk1? MXXTRW5ITVJ?
PANC-10-05 NELN[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPmd|NKSzVyPUK0OU42PiCwTR?= MnrZV2FPT0WU
NCI-H522 NHvuZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjhTWM2OD1{NEiuN|Ehdk1? NU\DR2Y1W0GQR1XS
A388 NUDaclRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHvTI1KSzVyPUK0PU45OiCwTR?= MX\TRW5ITVJ?
GOTO NWHGTWJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrWXGpKSzVyPUK1NE4zQSCwTR?= MULTRW5ITVJ?
KLE NYnpRldJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PWZmlEPTB;MkWxMlg4KG6P NUDIUoNEW0GQR1XS
KYSE-520 M4PNd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJ3Mj64OkBvVQ>? M1vGbnNCVkeHUh?=
HCE-4 NXPaRmVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXNRnFRUUN3ME2yOlIvPSCwTR?= MnTUV2FPT0WU
KURAMOCHI NHHSe5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XJZ2lEPTB;Mk[1Mlkhdk1? MX;TRW5ITVJ?
HCC38 MlSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K0d2lEPTB;Mk[2MlQ5KG6P M37sfnNCVkeHUh?=
FADU NGXBWlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnHUVFKSzVyPUK2Ok43OyCwTR?= NXP6[YZuW0GQR1XS
CW-2 M3;XUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH5NIlKSzVyPUK2PU46PiCwTR?= NIrVbY5USU6JRWK=
L-428 M1riPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnKNIFFUUN3ME2yO|UvOTVibl2= NU\ZOGxpW0GQR1XS
HCC1569 MnXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\wWHlKSzVyPUK3OU45PCCwTR?= MlrQV2FPT0WU
NCI-H810 MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rWVWlEPTB;Mke4MlMyKG6P NInOS29USU6JRWK=
LB771-HNC NIrrcGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1L1fWlEPTB;Mki1Mlg1KG6P NVHJdos2W0GQR1XS
LCLC-103H NX;UN2dXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjXTWM2OD1{OEWuPVkhdk1? NITifmZUSU6JRWK=
EFO-21 M1LwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL6d|BKSzVyPUK4O{43QCCwTR?= MofXV2FPT0WU
CAL-72 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXTTWM2OD1{OUOuNVkhdk1? NHrOe5pUSU6JRWK=
SCC-9 MmjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrXNGVsUUN3ME2yPVMvOjJibl2= MXrTRW5ITVJ?
COLO-829 MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzMTWM2OD1{OU[uOUBvVQ>? NVPXW|V1W0GQR1XS
U-87-MG NFO4WZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTpTWM2OD1|MECuO|Mhdk1? NHy5eIVUSU6JRWK=
MZ7-mel MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTN{Mz63OkBvVQ>? MUHTRW5ITVJ?
NCI-H1770 M{XzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImz[2VKSzVyPUOyOk44PCCwTR?= MmDXV2FPT0WU
ChaGo-K-1 M4rjeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDHTWM2OD1|MkiuNUBvVQ>? MnPiV2FPT0WU
SiHa MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrHPXJ3UUN3ME2zNlkvOjRibl2= NGD6O3RUSU6JRWK=
NCI-SNU-5 NF\INJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3MTWM2OD1|M{[uO|chdk1? MUfTRW5ITVJ?
DJM-1 NWradlV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G3bmlEPTB;M{SwMlM{KG6P NHTCSIRUSU6JRWK=
OE19 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfWTWM2OD1|NECuOVMhdk1? NUL6cWI6W0GQR1XS
NCI-H1651 MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDvU2VKSzVyPUO0OE4yQCCwTR?= NVfUTWlWW0GQR1XS
COLO-792 NX65PVZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjCfpJKSzVyPUO1OE41OiCwTR?= NGK3WGlUSU6JRWK=
ACHN MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\GfVZKSzVyPUO1Ok44OSCwTR?= MUPTRW5ITVJ?
TH-3 NXTSNJdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nhdGlEPTB;M{e5Mlk2KG6P NUizV|ZMW0GQR1XS
HT-1376 Ml\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLWUYxKSzVyPUO4OE45QCCwTR?= M3fONXNCVkeHUh?=
RH-18 MljjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvYTpBKSzVyPUO5OE44PCCwTR?= NYHTVo5bW0GQR1XS
NB6 NELQdZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3Q[3lKSzVyPUO5Ok43PiCwTR?= NXvsbo9EW0GQR1XS
COLO-320-HSR NVPBfXQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPHTWM2OD12MEOuN|chdk1? NX7pVGY2W0GQR1XS
UACC-893 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrEe3NzUUN3ME20NFYvPDdibl2= NWHtdIVjW0GQR1XS
DSH1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LMd2lEPTB;NEC2MlkyKG6P NFfrUnpUSU6JRWK=
TE-10 MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILZSXpKSzVyPUSwO{4xOSCwTR?= MV7TRW5ITVJ?
HCC70 M17QbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHKTWM2OD12MEmuNlEhdk1? NF[5d3lUSU6JRWK=
TGBC11TKB M2PJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXBTow3UUN3ME20NVAvOzNibl2= MV3TRW5ITVJ?
NCI-H727 M3iyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfuTWM2OD12MUKuNVEhdk1? M1vmRnNCVkeHUh?=
ALL-PO M1nPZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XUcmlEPTB;NEG1MlY6KG6P NYfEUXRkW0GQR1XS
ABC-1 MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPpTWM2OD12MkCuOFUhdk1? MYTTRW5ITVJ?
NCI-H69 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrq[GNKSzVyPUSyOk44PiCwTR?= Mkf1V2FPT0WU
GP5d MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTR|ND60NUBvVQ>? NXLzVpBxW0GQR1XS
UMC-11 NYnJVHVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXQTWM2OD12NUiuN|Yhdk1? M{\mbnNCVkeHUh?=
RMG-I NGHMOlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\rTWM2OD12NkeuOVYhdk1? NH3zT3RUSU6JRWK=
YAPC NGWxbFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XTcmlEPTB;NEmwMlYhdk1? M4rXRXNCVkeHUh?=
LS-1034 NFrB[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPwS4hmUUN3ME20PVEvODZibl2= M1jsT3NCVkeHUh?=
RCM-1 NXH5b25xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz0XXlnUUN3ME20PVYvPjhibl2= NHuyOItUSU6JRWK=
HCC1954 MkL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTBRmMxUUN3ME21NVIvPSCwTR?= MWfTRW5ITVJ?
SK-MEL-24 M1Th[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7MeIVNUUN3ME21NVYvPTFibl2= M1nXeXNCVkeHUh?=
NB12 NFfnNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnrTWM2OD13MkiuOFIhdk1? M1mxS3NCVkeHUh?=
SW756 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nHRmlEPTB;NUW0Mlk3KG6P M3znVnNCVkeHUh?=
HCC1187 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXCeJZUUUN3ME21O|UvQDNibl2= M1;4V3NCVkeHUh?=
NCI-H2342 M4fVc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1z0NWlEPTB;NUmwMlM6KG6P M{fGcXNCVkeHUh?=
NCI-H2291 M4LUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3GwW2lEPTB;NUm4MlMyKG6P NXK3NmQzW0GQR1XS
OVCAR-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTV7OD65OkBvVQ>? MnrKV2FPT0WU
MHH-NB-11 M{THNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjoNlZQUUN3ME22NlkvODFibl2= MmrxV2FPT0WU
SAS M1XGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPtdIlKSzVyPU[1Nk43PyCwTR?= M1Pm[3NCVkeHUh?=
COLO-824 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjwU2hKSzVyPU[4PU4{PyCwTR?= NWT5VYE{W0GQR1XS
HCC1395 NHvjcWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DGZ2lEPTB;Nkm4MlUhdk1? NILzcFlUSU6JRWK=
COLO-668 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\UN5JKSzVyPUewOk4yKG6P M3exWXNCVkeHUh?=
NCI-H226 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTdyNz64JI5O MoXvV2FPT0WU
NB17 NUDObJU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDiNVhYUUN3ME23NlEvPzVibl2= MUHTRW5ITVJ?
SW1463 MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\1U2lEPTB;N{O5MlE6KG6P M{XwRnNCVkeHUh?=
TGW NFW1PY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELpTXFKSzVyPUe2NE4yPSCwTR?= M{\aR3NCVkeHUh?=
NCI-H526 M3rIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTh{Mz61N{BvVQ>? M{DSWHNCVkeHUh?=
COR-L88 NFHL[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTjOpd2UUN3ME24OFgvOTJibl2= MYnTRW5ITVJ?
NCI-H441 NVrJRpJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2P3NmlEPTB;OEm1MlIzKG6P NVjueHhRW0GQR1XS
NCI-H630 M13uOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXySItKSzVyPUmxNk46PiCwTR?= Mlf4V2FPT0WU
Mo-T NXrzVnlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXwTWc5UUN3ME25OFcvQDhibl2= NH;PSoRUSU6JRWK=
JAR M4O2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LBUGlEPTB;OUW2MlI1KG6P MXzTRW5ITVJ?
NCI-H1838 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvROVA1UUN3ME2xMlAzOzh6IN88US=> MnzPV2FPT0WU
DoTc2-4510 NEHkOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjUUpZ[UUN3ME2xMlA4Ozd4IN88US=> NELrfoxUSU6JRWK=
MKN28 Mn;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nUSmlEPTB;MT6wPVAzPCEQvF2= Mlv2V2FPT0WU
HuP-T3 NXzNWJc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDGTWM2OD1zLkGxPVA2KM7:TR?= MoPEV2FPT0WU
TE-9 NHqxdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFwMUK5O|Mh|ryP NGTmPHRUSU6JRWK=
NY NFK0eFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFwMU[3PVIh|ryP M1LPfnNCVkeHUh?=
HT55 MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDJeXhFUUN3ME2xMlMyOzR2IN88US=> MXXTRW5ITVJ?
SW837 M3TwTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULCW5VTUUN3ME2xMlMzQTd6IN88US=> M1nJW3NCVkeHUh?=
NCI-H2029 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TXUGlEPTB;MT60NVc6OSEQvF2= MlvyV2FPT0WU
IST-SL1 NEO3cJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\JTWM2OD1zLkS0NlQh|ryP Mln6V2FPT0WU
COLO-741 MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;sSY1KSzVyPUGuOFk4PzFizszN M2i3RXNCVkeHUh?=
LU-65 M2m3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILBSFNKSzVyPUGuOlIzPDlizszN MWfTRW5ITVJ?
NCI-H1304 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XUZ2lEPTB;MT62OVQ6QCEQvF2= MYrTRW5ITVJ?
KARPAS-299 NHvBNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LjO2lEPTB;MT63PVQ4QSEQvF2= MYrTRW5ITVJ?
NCI-H358 M2THPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Da[WlEPTB;MT65OVUxOyEQvF2= NIrSUIhUSU6JRWK=
OAW-28 M2\jNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LRUmlEPTB;Mj6wOlkyQSEQvF2= MnPJV2FPT0WU
C8166 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\lTWM2OD1{Lk[zN|kzKM7:TR?= NED6WolUSU6JRWK=
COLO-678 NUXnU5U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr6TWM2OD1{LkizO|Y5KM7:TR?= Mm\IV2FPT0WU
SK-N-DZ M3jtUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2CxcmlEPTB;Mj64OlM5OSEQvF2= MX7TRW5ITVJ?
NCI-H82 NE\hTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DFUGlEPTB;Mj65NFM3QSEQvF2= NEnMPY5USU6JRWK=
JVM-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfEeFBKSzVyPUOuNFMyQDhizszN NXe1coYyW0GQR1XS
SW1116 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPHcIxZUUN3ME2zMlA2PDFzIN88US=> Mn;HV2FPT0WU
MDA-MB-453 NGD5O3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT3TWM2OD1|LkGwOFM6KM7:TR?= MorDV2FPT0WU
Calu-6 NH\hR|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfXTWM2OD1|LkG5PVch|ryP M1fyO3NCVkeHUh?=
SHP-77 NIHPUIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\5eHdKSzVyPUOuOVI5KM7:TR?= NXLZc2s3W0GQR1XS
Capan-2 NVvlZ2VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\yUYp4UUN3ME20MlMzPThzIN88US=> NGL3fY1USU6JRWK=
SW948 M4\iRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq4XlVKSzVyPUSuO|Q4PzlizszN M1fHRXNCVkeHUh?=
HDLM-2 NGjCcHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILh[nZKSzVyPUWuNFc4OjVizszN Mn\kV2FPT0WU
LAN-6 NVL3c2R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjuXHZkUUN3ME22MlIyPDl3IN88US=> MX\TRW5ITVJ?
LU-135 MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHMUGtKSzVyPU[uOFMxPzdizszN M{[4N3NCVkeHUh?=
T84 MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XX[2lEPTB;Nj65PFY1KM7:TR?= Ml3rV2FPT0WU
CAPAN-1 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTdwNkKyN|Mh|ryP NEWyd5ZUSU6JRWK=
SW1417 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mor1TWM2OD15LkmxO|MyKM7:TR?= NWHZZZRlW0GQR1XS
BALL-1 M2\nWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e2O2lEPTB;OD61NFQxQSEQvF2= MVLTRW5ITVJ?
HT-29 Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGq2UI9KSzVyPUmuNFc2QTlizszN MX7TRW5ITVJ?
C3A MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfWTWM2OD17Lki4N|k1KM7:TR?= MlrzV2FPT0WU
NCI-H1993 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTFyLkWwPFEh|ryP MlzHV2FPT0WU
SK-MEL-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7wTWM2OD1zMT62Nlg6KM7:TR?= MYHTRW5ITVJ?
DU-145 NET3Z4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnITWM2OD1zND61NFUzKM7:TR?= M4q3TXNCVkeHUh?=
KP-N-YN MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHJTWM2OD1zND61NVA{KM7:TR?= NV3TRlNNW0GQR1XS
CCRF-CEM NWmxUXdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X3fGlEPTB;MUSuO|gxQSEQvF2= M4PVSHNCVkeHUh?=
ZR-75-30 NHPUOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7iTWM2OD1zNj6zN|A{KM7:TR?= M2PaZXNCVkeHUh?=
A673 MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJyLkW1NFch|ryP MmG5V2FPT0WU
K-562 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\B[GlEPTB;MkiuOFE5OyEQvF2= NHKyPWdUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

In vitro Protein Kinase, PI3K, and mTOR Assays PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.

細胞アッセイ:

[2]

細胞株 HCT116, DLD-1 and SW480 cells
濃度 0-1 μM
反応時間 48 hours
実験の流れ

The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.

動物実験:

[1]

動物モデル Female Harlan athymic nude mice
製剤 NMP/polyethylene glycol 300 (10/90, v/v)
投薬量 45 mg/kg
投与方法 p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BEZ235 (NVP-BEZ235, Dactolisib) SDF
分子量 469.55
化学式

C30H23N5O

CAS No. 915019-65-7
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMF 18 mg/mL warming (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
<1 mg/mL (<1 mM)
In vivo NMP+polyethylene glycol 300 (10+90, v+v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

文献中の引用 (81)

Frequently Asked Questions

  • Question 1
    With difficulties in dissolving BEZ235, How can I improve its solubility?

    Answer: For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related PI3K 阻害剤

  • GDC-0032

    GDC-0032 is a potent, next-generation PI3K inhibitor targeting PI3K alpha.

    Features:A beta isoform-sparing PI3K inhibitor.

  • Pilaralisib (XL147)

    Pilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2.

  • GNE-317

    GNE-317 is a potent, brain-penetrant PI3K inhibitor.

  • PI-3065

    PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, >70-fold selectivity over other PI3K family members.

  • LY294002

    LY294002は、p110α、p110δとp110βのPI3K阻害剤で、IC50 がそれぞれ 0.5 μM、0.57 μM、0.97 μMです。

  • 3-Methyladenine (3-MA)

    3-Methyladenine (3-MA) は選択の自噬とリン酸イノシトール3キナーゼ(キナーゼ)阻害剤、Vps34 と PI3Kγ に作用する時、 IC50 がそれぞれ 25 nM と 60 nM になる。自動食物胞の形成を妨害すること。

  • CAL-101 (Idelalisib, GS-1101)

    CAL-101 (Idelalisib, GS-1101)は、2.5nMのIC50によるp110δの選択的なPI3KクラスI阻害剤です。

  • Wortmannin

    ワートマニンはミオシン軽鎖キナーゼ(MLCK)のマルチターゲットの阻害剤、IC50がぞれぞれ0.17μMと3nMになる。自動食物胞の形成を妨害すること。

  • BKM120 (NVP-BKM120, Buparlisib)

    BKM120 (NVP-BKM120, Buparlisib)は、p110α、p110β、p110δとp110γの選択的なPI3K阻害剤で、IC50 がそれぞれ 52-99 nM、166 nM、 116 nM、 262 nMです。

最近チェックしたアイテム

Tags: BEZ235 (NVP-BEZ235, Dactolisib)を買う | BEZ235 (NVP-BEZ235, Dactolisib)供給者 | BEZ235 (NVP-BEZ235, Dactolisib)を購入する | BEZ235 (NVP-BEZ235, Dactolisib)費用 | BEZ235 (NVP-BEZ235, Dactolisib)生産者 | オーダーBEZ235 (NVP-BEZ235, Dactolisib) | BEZ235 (NVP-BEZ235, Dactolisib)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ