Dactolisib (BEZ235, NVP-BEZ235)

製品コードS1009

Dactolisib (BEZ235, NVP-BEZ235)化学構造

分子量(MW):469.55

Dactolisib (BEZ235, NVP-BEZ235)は一種の二重ATP競争性PI3KとmTOR阻害剤で、無細胞試験でp110α/γ/δ/β/mTOR(p70S6K)を抑制する時のIC50値は 4 nM /5 nM /7 nM /75 nM /6 nMそれぞれ分かれます。BEZ235 (NVP-BEZ235,Dactolisib)はT3TopBP1-ER 細胞の中でATRを抑制して、IC50 値が21 nMになって、Akt とPDK1に作用することが弱くなります。臨床2期。

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文献中の引用(81)

カスタマーフィードバック(10)

  • Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

     After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

     

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

製品安全説明書

PI3K阻害剤の選択性比較

生物活性

製品説明 Dactolisib (BEZ235, NVP-BEZ235)は一種の二重ATP競争性PI3KとmTOR阻害剤で、無細胞試験でp110α/γ/δ/β/mTOR(p70S6K)を抑制する時のIC50値は 4 nM /5 nM /7 nM /75 nM /6 nMそれぞれ分かれます。BEZ235 (NVP-BEZ235,Dactolisib)はT3TopBP1-ER 細胞の中でATRを抑制して、IC50 値が21 nMになって、Akt とPDK1に作用することが弱くなります。臨床2期。
靶点
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro試験

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MlTyRY51cW2rY4LvZolidCCDc4PhfS=> M2\mb|E5KGh? M2jPT2ROW09? NE\LdINCdnSrdIL5dIFvd3OxbXHsJIFkfGm4aYT5JJdqfGhiRVO1NEBw\iByLkCwNlUh|ryP NGf0W5EzPDhyNUm0Oi=>
MCF7 NH\hVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DvSlAvODFvMUCwJO69VQ>? MYK0PEBp NF\qT5hFVVOR NFHIVmRKSzVyPUCuO|Mh|ryP MXSyN|g4OTlyNB?=
HCT116 M4jxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ThS|AvODFvMUCwJO69VQ>? NHvSNVM1QCCq NU\zcnFSTE2VTx?= MVTJR|UxRTFwMU[g{txO NIrVXYQzOzh5MUmwOC=>
U87MG NXrwUHBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXiwMlAyNTFyMDFOwG0> NUfPOoZMPDhiaB?= MV;EUXNQ NWTuXIdDUUN3ME2xMlMzKM7:TR?= NGHLWWYzOzh5MUmwOC=>
HBC4 NFjjUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfDSpIxNjBzLUGwNEDPxE1? M{\3S|Q5KGh? NXjQPHZvVG:pIFfJOVA:NThwNkGgUS=> MkjwNlI{OzZ{NE[=
BSY1 NY\QTmg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSwMlAyNTFyMDFOwG0> MoDROFghcA>? MVTMc4chT0l3ME2tPE41QCCP NEjJVVgzOjN|NkK0Oi=>
HBC5 M{PwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\LNE4xOS1zMECg{txO NVTUVFUyPDhiaB?= NXPVXpo3VG:pIFfJOVA:NTdwOEegUS=> NXrRdJZPOjJ|M{[yOFY>
MCF7 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETCcYMxNjBzLUGwNEDPxE1? MXy0PEBp NX\RUYxOVG:pIFfJOVA:NThwMU[gUS=> M1XmeVIzOzN4MkS2
MDA-MB-231 NGLXUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWwXnV2OC5yMT2xNFAh|ryP M1;Hb|Q5KGh? NFvXflNNd2diR1m1NF0uQC5yOTDN NHv4Vm8zOjN|NkK0Oi=>
U251 NHHkVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLUSmRPOC5yMT2xNFAh|ryP MmD6OFghcA>? NFe0ZXlNd2diR1m1NF0uPy54NjDN M3rXUFIzOzN4MkS2
SF268 NHLrRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnZeHh4OC5yMT2xNFAh|ryP NEDY[lE1QCCq MV;Mc4chT0l3ME2tO{46OiCP M2HuPFIzOzN4MkS2
SF295 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\IN294OC5yMT2xNFAh|ryP NX\ONIFHPDhiaB?= M3\S[mxw\yCJSUWwQU05NjNzIF2= NXnTcpc4OjJ|M{[yOFY>
SF539 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\BNE4xOS1zMECg{txO MnvVOFghcA>? NHH2eJJNd2diR1m1NF0uQC53OTDN MnK0NlI{OzZ{NE[=
SNB75 M1P0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnpToYxNjBzLUGwNEDPxE1? MojIOFghcA>? NVrWVJVVVG:pIFfJOVA:NThwNUigUS=> MXOyNlM{PjJ2Nh?=
SNB78 NGj1TW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnh[m1VOC5yMT2xNFAh|ryP NYnVW4I1PDhiaB?= MYLMc4chT0l3ME2tPE43PSCP MnHINlI{OzZ{NE[=
HCC2998 M{HROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\jUJMxNjBzLUGwNEDPxE1? Mn\lOFghcA>? MYXMc4chT0l3ME2tPE4xPSCP NX70fXIxOjJ|M{[yOFY>
KM12 NELiZpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vHXFAvODFvMUCwJO69VQ>? MnSzOFghcA>? NHLMW5JNd2diR1m1NF0uPy53NDDN NIribZEzOjN|NkK0Oi=>
HT-29 MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\oNE4xOS1zMECg{txO NFXrZng1QCCq NIP0UYVNd2diR1m1NF0uPy55NTDN MV[yNlM{PjJ2Nh?=
HCT15 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnSPGUxNjBzLUGwNEDPxE1? M37DVVQ5KGh? NX;xZnp6VG:pIFfJOVA:NThwMEOgUS=> NGDXSpczOjN|NkK0Oi=>
HCT116 NHj5eYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTVNE4xOS1zMECg{txO M17ob|Q5KGh? NYmwXJQyVG:pIFfJOVA:NTdwNkGgUS=> MnSxNlI{OzZ{NE[=
NCI-H23 NFjKc2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPPencxNjBzLUGwNEDPxE1? Ml7MOFghcA>? NUDifXVZVG:pIFfJOVA:NTdwNkSgUS=> NXX5TFduOjJ|M{[yOFY>
NCI-H226 M{TnSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rNTVAvODFvMUCwJO69VQ>? MnvXOFghcA>? NGfkXJRNd2diR1m1NF0uQC52NDDN M1POWFIzOzN4MkS2
NCI-H522 NE\4[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHO0eGwxNjBzLUGwNEDPxE1? NV3Mc2hKPDhiaB?= NY[z[GdwVG:pIFfJOVA:NThwNEWgUS=> NWD6ZnhCOjJ|M{[yOFY>
NCI-H438 NXrBUGhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3mNE4xOS1zMECg{txO M2DCelQ5KGh? NVW4eIhYVG:pIFfJOVA:NThwMUGgUS=> MojaNlI{OzZ{NE[=
A549 MnzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljZNE4xOS1zMECg{txO NH\KWWs1QCCq NF72VGNNd2diR1m1NF0uQC5yNzDN NG\KRlQzOjN|NkK0Oi=>
DMS273 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXKSotTOC5yMT2xNFAh|ryP M3vQUFQ5KGh? NWXTWmFCVG:pIFfJOVA:NTdwOECgUS=> NYLUS2lKOjJ|M{[yOFY>
DMS114 NGjWXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUSwMlAyNTFyMDFOwG0> MlzSOFghcA>? NHnZZnVNd2diR1m1NF0uQC5|OTDN MX2yNlM{PjJ2Nh?=
LOXIMVI NH7yOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWewMlAyNTFyMDFOwG0> M4PUUVQ5KGh? MknoUI9oKEeLNUC9MVgvPjZiTR?= M4roRVIzOzN4MkS2
OVCAR3 NUHiWlVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1exXlAvODFvMUCwJO69VQ>? MYi0PEBp NGfHeY5Nd2diR1m1NF0uQC5zNzDN M2jMVVIzOzN4MkS2
OVCAR4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrMZ3IxNjBzLUGwNEDPxE1? MnfWOFghcA>? MkXNUI9oKEeLNUC9MVgvPThiTR?= NHfqTI8zOjN|NkK0Oi=>
OVCAR5 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrjRogxNjBzLUGwNEDPxE1? M1zTcVQ5KGh? M4C4OGxw\yCJSUWwQU04NjV5IF2= M{XablIzOzN4MkS2
OVCAR8 MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v0RVAvODFvMUCwJO69VQ>? M{HWTFQ5KGh? MmrsUI9oKEeLNUC9MVcvQDRiTR?= NWLvT|JPOjJ|M{[yOFY>
SKOV3 NUTJZ4NrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX[wMlAyNTFyMDFOwG0> NV23TXZjPDhiaB?= NEWweYhNd2diR1m1NF0uQC52MTDN M{H2RVIzOzN4MkS2
RXF631L M3HtWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFna[I8xNjBzLUGwNEDPxE1? MoXQOFghcA>? M3f5Xmxw\yCJSUWwQU05NjJzIF2= M3LYXlIzOzN4MkS2
ACHN NXHyRopXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKwMlAyNTFyMDFOwG0> NF:yNHM1QCCq MknhUI9oKEeLNUC9MVcvQTViTR?= NYLVRVRUOjJ|M{[yOFY>
St-4 MliyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmwMlAyNTFyMDFOwG0> M4K5U|Q5KGh? M3fzVWxw\yCJSUWwQU04NjR5IF2= NYW5eZR5OjJ|M{[yOFY>
MKN1 M1HiOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXpNE4xOS1zMECg{txO NX3lW5BHPDhiaB?= MnvyUI9oKEeLNUC9MVgvPDFiTR?= NILW[3EzOjN|NkK0Oi=>
MKN7 NE\ycIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Pod|AvODFvMUCwJO69VQ>? MYi0PEBp MoPxUI9oKEeLNUC9MVcvPjhiTR?= M4rINFIzOzN4MkS2
MKN28 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLlSGlPOC5yMT2xNFAh|ryP MXK0PEBp NXrzRZp3VG:pIFfJOVA:NTdwMEegUS=> MWWyNlM{PjJ2Nh?=
MKN45 NIjTbY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonxNE4xOS1zMECg{txO NWjaTZViPDhiaB?= NUiwfWx7VG:pIFfJOVA:NThwM{SgUS=> NF\HOXczOjN|NkK0Oi=>
MKN74 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MViwMlAyNTFyMDFOwG0> MX[0PEBp MVjMc4chT0l3ME2tO{41OiCP NUDIdHN1OjJ|M{[yOFY>
DU145 NHvoTlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVywMlAyNTFyMDFOwG0> Ml:0OFghcA>? NHrU[|ZNd2diR1m1NF0uQC5zNjDN NEHhfIczOjN|NkK0Oi=>
PC3 NXLpVoJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rReVAvODFvMUCwJO69VQ>? NYS1N2tkPDhiaB?= MlHJUI9oKEeLNUC9MVgvPjZiTR?= NF[1dGozOjN|NkK0Oi=>
Trypanosoma brucei brucei M4DOTmZ2dmO2aX;uJGF{e2G7 NGDOfWozODBibl2= NUf1RlFuOTJiaB?= MXHEUXNQ MXzE[YNz\WG|ZTDpckBxcG:|cHjveIllgWxiaX7vd4l1d2xicHjvd5Bp[XSnIHzleoVt M2TRW|I1QDB3OUS2
Trypanosoma brucei brucei MXTGeY5kfGmxbjDBd5NigQ>? Mlr6NVghcA>? NYTnUYF6TE2VTx?= M1\XTGlvcGmkaYTpc44hd2ZicnXj[ZB1d3JvbXXkbYF1\WRiZX7kc4N6fG:|aYOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5idILhcpNn\XK{aX6geZB1[Wun NH7hSI8zPDhyNUm0Oi=>
Trypanosoma brucei brucei NYC1XmdCTnWwY4Tpc44hSXO|YYm= NEfkV3UzODBibl2= NUP6fFhuOTJiaB?= MVTEUXNQ NEDm[WpG\m[nY4Sgc44he3CqaX7nc416dGWrbjDs[ZZmdA>? NIrhXFQzPDhyNUm0Oi=>
Trypanosoma brucei brucei MkPUSpVv[3Srb36gRZN{[Xl? MYqyNFAhdk1? NWLUcWs{OTJiaB?= NYP5cFFsTE2VTx?= NHn0PFBG\m[nY4Sgc44heGixc4DoZZRq\HmuY3jvcIlv\SCuZY\lcC=> NFjXcFIzPDhyNUm0Oi=>
UM-UC-3 NWjieo5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\PdWlEPTB;M{G1JJBO NGXD[49USU6JRWK=
SBC-1 M3r3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTd2MjDwUS=> NUTJVZVSW0GQR1XS
MKN1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJwODDuUS=> MXXTRW5ITVJ?
NCI-H720 MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj1ZopKSzVyPUOuOVchdk1? MVLTRW5ITVJ?
BFTC-909 Mor2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTiU2tKSzVyPUOuO|Ehdk1? MoDuV2FPT0WU
BPH-1 NFLiSZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfhTWM2OD12Lke2JI5O NFT0NZNUSU6JRWK=
PC-3 M4jnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTVwMEmgcm0> Mlz2V2FPT0WU
AN3-CA MkP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\hOHlyUUN3ME21MlU3KG6P NYTYSYV6W0GQR1XS
HN NYTsfFhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTVwOU[gcm0> NXP5eHJrW0GQR1XS
HCC2218 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHHSYZKSzVyPU[uOlEhdk1? MXfTRW5ITVJ?
KP-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvWbWpnUUN3ME23JI5O M3mwU3NCVkeHUh?=
LU-139 NV7oVVAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnkbm1JUUN3ME23Mlc4KG6P NVq5RphFW0GQR1XS
ETK-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTdwOEigcm0> NETabopUSU6JRWK=
Ramos-2G6-4C10 M1\afGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\rNIFHUUN3ME24MlQ6KG6P NIKzSItUSU6JRWK=
MHH-PREB-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnpTWM2OD17LkGyJI5O NILZ[oFUSU6JRWK=
DU-4475 NGfPW4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLyTWM2OD17LkS0JI5O NFHIR3BUSU6JRWK=
NCI-H1666 M{LhSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTlwN{Ggcm0> MlfHV2FPT0WU
CAMA-1 NGf2U|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLjTWM2OD17Lkigcm0> MV\TRW5ITVJ?
TYK-nu Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHjeZF4UUN3ME25Mlk1KG6P Mlf0V2FPT0WU
MFE-280 NHz6ZZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTlwOUmgcm0> MkLuV2FPT0WU
A549 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LobGlEPTB;MUCuNVQhdk1? MXLTRW5ITVJ?
769-P MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1izNWlEPTB;MUCuOFQhdk1? M4W4cnNCVkeHUh?=
L-363 NUTic3RyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TsUGlEPTB;MUCuOlkhdk1? MVHTRW5ITVJ?
ES8 NFztWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPCPXlKSzVyPUGwMlkhdk1? MUfTRW5ITVJ?
PA-1 Mn7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFzLkiyJI5O NE\mRVlUSU6JRWK=
Mewo MkSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFzLkm5JI5O NIjFc4NUSU6JRWK=
HSC-3 MlvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF{LkKxJI5O NXfyTI9jW0GQR1XS
H4 M{nKT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf2VHA2UUN3ME2xNk43PyCwTR?= NVrzRZV7W0GQR1XS
BB65-RCC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zpWGlEPTB;MUKuO|Ihdk1? NYPxd3dpW0GQR1XS
NCI-H1793 NF\oSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\venB{UUN3ME2xNk45OiCwTR?= NXLnPZNMW0GQR1XS
KARPAS-45 NW\WToEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XiNWlEPTB;MUOuOVEhdk1? MWXTRW5ITVJ?
GCT NX3GfYx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n3UGlEPTB;MUOuOlghdk1? NXjKR5lYW0GQR1XS
EoL-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HHdWlEPTB;MUOuPVMhdk1? MkSwV2FPT0WU
LB2241-RCC NWfJfHhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7Ob|RDUUN3ME2xOE4xOSCwTR?= NVvNS21XW0GQR1XS
ES5 NHz0fVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LSUmlEPTB;MUSuO|Qhdk1? NHrLSpdUSU6JRWK=
LOXIMVI MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfDOpJKUUN3ME2xOE46QSCwTR?= NEnlU|BUSU6JRWK=
COR-L105 NHjsNHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLGT|RDUUN3ME2xOU4xPCCwTR?= M4WwfHNCVkeHUh?=
P12-ICHIKAWA MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTF3LkGgcm0> MVLTRW5ITVJ?
CHL-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLZTWM2OD1zNT60OUBvVQ>? MlTlV2FPT0WU
VMRC-RCZ NH3UcVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPBb4dKSzVyPUG1MlY{KG6P MVXTRW5ITVJ?
HH MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Tje2lEPTB;MUWuO{BvVQ>? M3nLUHNCVkeHUh?=
NUGC-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrFWWI6UUN3ME2xOk4{PCCwTR?= MYDTRW5ITVJ?
EGI-1 MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF4LkSzJI5O NVf1cHpxW0GQR1XS
OS-RC-2 Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\qd3BKSzVyPUG2MlQ4KG6P NWHZXY1SW0GQR1XS
MOLT-16 Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnvTFVKSzVyPUG3MlE2KG6P MoXpV2FPT0WU
NCI-H209 M2fRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILzfWZKSzVyPUG3MlI6KG6P Ml\BV2FPT0WU
697 NHG1T49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzhfGVKSzVyPUG3MlQ{KG6P NYS1eIxnW0GQR1XS
D-56MG NV[0d2J4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjpWmQ5UUN3ME2xO{43QSCwTR?= NUKxPVI4W0GQR1XS
VA-ES-BJ M3L4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP0cnVKSzVyPUG3Mlg{KG6P NXHwOpdMW0GQR1XS
EW-16 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF6LkC0JI5O MWLTRW5ITVJ?
HGC-27 M{m2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PVeGlEPTB;MUiuNFYhdk1? Mn32V2FPT0WU
ES7 NYnCeHBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPZNXh6UUN3ME2xPE4xQSCwTR?= NETmeFVUSU6JRWK=
HuH-7 NEO2OYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPrR25KSzVyPUG4MlQhdk1? NF7SZZFUSU6JRWK=
BCPAP NYTtWJJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P3bmlEPTB;MUiuOlUhdk1? M{XiR3NCVkeHUh?=
SW1710 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj6TWM2OD1zOD63NkBvVQ>? MWTTRW5ITVJ?
IST-MEL1 M1;hRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF6Lke3JI5O Mm\zV2FPT0WU
SF295 M1z0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTF6LkmzJI5O M4HtfnNCVkeHUh?=
RPMI-7951 NX;0Z|RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIW3T|VKSzVyPUG5MlI5KG6P M3;6b3NCVkeHUh?=
SF126 NHmyPHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\JWGlEPTB;MUmuOFEhdk1? M4\rdnNCVkeHUh?=
GAMG MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TMeWlEPTB;MUmuOFghdk1? NEPvRnJUSU6JRWK=
KNS-81-FD M{\tfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DMcmlEPTB;MUmuOVQhdk1? NHnEeldUSU6JRWK=
RT-112 M1v3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfJNFBKSzVyPUG5MlY3KG6P NITZW2NUSU6JRWK=
DEL NYG0dmpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13OcWlEPTB;MkCuOFkhdk1? NGGyUFJUSU6JRWK=
CGTH-W-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXjNZc4UUN3ME2yNE43OyCwTR?= NI\MWJdUSU6JRWK=
HOS Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXwPHFTUUN3ME2yNU4xPiCwTR?= MXfTRW5ITVJ?
ES4 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTCSIZKSzVyPUKxMlA5KG6P MnrzV2FPT0WU
RXF393 NGPsV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDjPY1KSzVyPUKxMlQ2KG6P MmTzV2FPT0WU
NCI-H2030 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLmTWM2OD1{MT61NkBvVQ>? M3nxNnNCVkeHUh?=
YH-13 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f1N2lEPTB;MkGuPFghdk1? Mni4V2FPT0WU
HT-1080 NXm2OYZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\2TWM2OD1{MT65N{BvVQ>? NWXMZZJtW0GQR1XS
NCI-SNU-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu3dWNHUUN3ME2yNU46PSCwTR?= NIrY[5lUSU6JRWK=
G-402 NYKxdmdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGW1WWhKSzVyPUKyMlE3KG6P NUjkWmpzW0GQR1XS
786-0 NFvVR5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;0XGlEPTB;MkKuNlkhdk1? NIjFem1USU6JRWK=
ME-180 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJ{LkSzJI5O MXjTRW5ITVJ?
NB69 NFvjdJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj1XGhKSzVyPUKyMlU{KG6P NWnROmZsW0GQR1XS
J-RT3-T3-5 NUfvW4tUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJ{Lkm2JI5O M1nrO3NCVkeHUh?=
TGBC1TKB M1HDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ|LkC1JI5O MoHpV2FPT0WU
SW780 NEHY[nNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ|LkGzJI5O M1rPSnNCVkeHUh?=
MG-63 NVvhbodxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID2cFFKSzVyPUKzMlQ2KG6P Mn3nV2FPT0WU
BV-173 NIHMSodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv2WYdJUUN3ME2yN{45PyCwTR?= NFntPGlUSU6JRWK=
CAL-51 NEjXVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTve|hKSzVyPUKzMlg6KG6P NFfLO5RUSU6JRWK=
A375 NXXGNmprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\K[XdKSzVyPUKzMlk{KG6P MX7TRW5ITVJ?
MEL-HO NH7UUZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[wV5hZUUN3ME2yOE4xPCCwTR?= NWj6R4N6W0GQR1XS
EFO-27 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXyTWM2OD1{ND6zN{BvVQ>? NXX0dW9LW0GQR1XS
Hs-578-T NVXqT29FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\DUWZ4UUN3ME2yOE42QCCwTR?= Ml;tV2FPT0WU
NBsusSR NYfYPFFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHZVoJlUUN3ME2yOE43KG6P Mnv4V2FPT0WU
CTB-1 MknZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nHUmlEPTB;MkSuOlchdk1? M{Dp[3NCVkeHUh?=
FTC-133 MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jUWWlEPTB;MkWuNUBvVQ>? NITZd2lUSU6JRWK=
MOLT-4 NX;oWmpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rqc2lEPTB;MkWuNVIhdk1? NGfsbVBUSU6JRWK=
HO-1-N-1 M1nY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJ3LkG1JI5O M1XaPXNCVkeHUh?=
ES3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\0XGZDUUN3ME2yOU4zOiCwTR?= NWiz[Wp2W0GQR1XS
TI-73 M4HGVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXR[od7UUN3ME2yOU4zQCCwTR?= NWqw[IR6W0GQR1XS
MPP-89 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrWS4tKSzVyPUK1MlMzKG6P MXHTRW5ITVJ?
KYSE-150 NHL4dmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7pV3d3UUN3ME2yOU45QSCwTR?= NWXqfWtyW0GQR1XS
LXF-289 MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TaWWlEPTB;Mk[uNFQhdk1? M2Dxb3NCVkeHUh?=
SK-LU-1 NWXqcmxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\rVGlEPTB;Mk[uNVchdk1? NVXBbJVHW0GQR1XS
HOP-92 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;Wd|hkUUN3ME2yOk41QCCwTR?= MWTTRW5ITVJ?
HuO9 NWHoPXJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:3NGlEPTB;Mk[uO|Yhdk1? M{f6[3NCVkeHUh?=
SW962 MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3aRnRKSzVyPUK2Mlc3KG6P NWi0dmlnW0GQR1XS
RS4-11 NUDSR4hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzFU5V{UUN3ME2yOk46OSCwTR?= MWjTRW5ITVJ?
NCI-H292 M2TRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPETWM2OD1{NzDuUS=> NGHVN3RUSU6JRWK=
DB NH3sRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLuTWM2OD1{Nz6zOkBvVQ>? NXviNJp4W0GQR1XS
SW1088 M3Wyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HsVmlEPTB;MkiuNlkhdk1? MmDYV2FPT0WU
A204 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXtTWM2OD1{OD60O{BvVQ>? NUXCOJhPW0GQR1XS
A3-KAW NF23WGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnaTWM2OD1{OD62OEBvVQ>? MXnTRW5ITVJ?
MV-4-11 MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\nWmlEPTB;MkiuO{BvVQ>? NXyzeoY{W0GQR1XS
ES1 NIj6PYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTqTWM2OD1{OD64OEBvVQ>? NVPScHV2W0GQR1XS
ONS-76 NH7XflNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzXcmp1UUN3ME2yPU4xPSCwTR?= MoXDV2FPT0WU
D-263MG M{jIdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XUbmlEPTB;MkmuN|Uhdk1? MY\TRW5ITVJ?
U-2-OS MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDLTWM2OD1{OT61JI5O Mmn1V2FPT0WU
T98G NV[4NoR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTyTnk6UUN3ME2yPU45QCCwTR?= NX;UWmQ3W0GQR1XS
GI-ME-N MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfSXm1KSzVyPUK5MlkyKG6P NX70dWg2W0GQR1XS
BHT-101 MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTNyLkC1JI5O NFrm[G5USU6JRWK=
NOS-1 NGfGRpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPSTWM2OD1|MD6xNkBvVQ>? M3XrbHNCVkeHUh?=
AsPC-1 M4m0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPS[3dDUUN3ME2zNE4zKG6P M2rFZXNCVkeHUh?=
QIMR-WIL MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml35TWM2OD1|MD62JI5O NVG1NohbW0GQR1XS
JVM-3 MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjrNnNKSzVyPUOwMlg{KG6P NFvNWYlUSU6JRWK=
KU-19-19 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXSW2NKSzVyPUOxMlE{KG6P NFezZW5USU6JRWK=
OVCAR-8 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTNzLkK2JI5O MYjTRW5ITVJ?
BEN MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPvTWM2OD1|MT62N{BvVQ>? MWrTRW5ITVJ?
BE-13 Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PCemlEPTB;M{GuPFIhdk1? MnqwV2FPT0WU
EW-18 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTlTWM2OD1|MT64OkBvVQ>? MWLTRW5ITVJ?
ECC10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTNzLkm1JI5O MnLsV2FPT0WU
CTV-1 NGPoVVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLvWHNYUUN3ME2zNk45OiCwTR?= MkDUV2FPT0WU
COLO-800 M1G0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTN{LkmyJI5O M33CWnNCVkeHUh?=
A2058 Mo\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjoR3pKSzVyPUOzMlI2KG6P NGDOc3FUSU6JRWK=
VM-CUB-1 NX;zRYJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG2fGRZUUN3ME2zN{41OyCwTR?= NVnFcZNJW0GQR1XS
Ca9-22 M{DYN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP4TWM2OD1|Mz61OUBvVQ>? MlLVV2FPT0WU
COLO-684 M2jVcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mln5TWM2OD1|Mz61PEBvVQ>? M1XRfHNCVkeHUh?=
RPMI-8226 NFnEWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv3U|drUUN3ME2zN{45OiCwTR?= M{TJenNCVkeHUh?=
SK-NEP-1 Mo\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTN2LkG1JI5O MVrTRW5ITVJ?
Becker NXLX[5VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTN2LkKxJI5O NYDSO3Q6W0GQR1XS
NCI-H28 NGXDeW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfsTWM2OD1|ND60OEBvVQ>? MWHTRW5ITVJ?
CAL-120 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzzTWM2OD1|ND63NkBvVQ>? Mlj4V2FPT0WU
MDA-MB-157 NGSyWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTwTWM2OD1|NT60NUBvVQ>? MojSV2FPT0WU
OVCAR-5 M37Ucmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLTTWM2OD1|NT60O{BvVQ>? NGXmSWxUSU6JRWK=
LAMA-84 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny1TWM2OD1|NT64O{BvVQ>? MkfSV2FPT0WU
CAKI-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTN4LkSzJI5O M4DMWHNCVkeHUh?=
Daoy M{XmO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7oTWM2OD1|Nj63JI5O NVrsNGRoW0GQR1XS
CAL-62 M3\qXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTN4Lki2JI5O NETFWJlUSU6JRWK=
8-MG-BA NWXvcHZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX0TWM2OD1|Nz6yOUBvVQ>? MV7TRW5ITVJ?
8505C MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXadmZKSzVyPUO3MlUyKG6P MX;TRW5ITVJ?
LNCaP-Clone-FGC NYLZdWpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T6SmlEPTB;M{euOVkhdk1? NGjUbFBUSU6JRWK=
CAL-39 NWmzO3JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn25TWM2OD1|Nz65JI5O NVz1fINzW0GQR1XS
MN-60 MlnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTN5Lkm2JI5O NFTW[G5USU6JRWK=
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U251 NX20RmdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3IT2ZZUUN3ME2zPE41OyCwTR?= NHriTopUSU6JRWK=
SJSA-1 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfZ[mNKSzVyPUO4MlU1KG6P NV22SmdiW0GQR1XS
CAL-12T M3HYcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPKOolwUUN3ME2zPE43KG6P NFvSS4dUSU6JRWK=
HCC1419 NVnxeoU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;OTWM2OD1|OD63NUBvVQ>? MVjTRW5ITVJ?
CO-314 MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3JcHZqUUN3ME2zPE44PCCwTR?= M3S4eHNCVkeHUh?=
LB1047-RCC NICzUXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTN6LkixJI5O MmnlV2FPT0WU
A101D M4HLcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDoRnZ[UUN3ME2zPE46PyCwTR?= MmrDV2FPT0WU
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MZ2-MEL MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXkbWNKSzVyPUO5MlY3KG6P M2HzOHNCVkeHUh?=
NB5 MmiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXWT3c3UUN3ME20NE43PCCwTR?= NGDtOGNUSU6JRWK=
G-401 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTRyLkiyJI5O NFfIO2FUSU6JRWK=
HT MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jyUGlEPTB;NEGuNFIhdk1? M13tdnNCVkeHUh?=
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BHY NXnK[|Y4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXmwTIc{UUN3ME20Nk44OiCwTR?= NEjYVJpUSU6JRWK=
NTERA-S-cl-D1 Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnZ[VlKUUN3ME20N{BvVQ>? M2rR[HNCVkeHUh?=
T-24 M1rGb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTR|LkizJI5O M3Hkb3NCVkeHUh?=
EPLC-272H M1W2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi3dXlKSzVyPUS0MlM6KG6P NULqbY1oW0GQR1XS
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NCI-H2452 NEnQb5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTR2LkW4JI5O NGKzUlZUSU6JRWK=
KS-1 MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTR2Lk[2JI5O MYnTRW5ITVJ?
HD-MY-Z M4HoXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33BcWlEPTB;NESuPVIhdk1? MniwV2FPT0WU
KNS-62 MlT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHrPWs3UUN3ME20OU4{QCCwTR?= MVjTRW5ITVJ?
NOMO-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTR3Lki3JI5O MnrTV2FPT0WU
SK-HEP-1 NVzNcHB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LYTGlEPTB;NE[uNFQhdk1? NVTGV|NuW0GQR1XS
IGR-1 NH33V2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFSxSFFKSzVyPUS2MlE{KG6P MUXTRW5ITVJ?
KYSE-180 M4rO[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nKN2lEPTB;NE[uNVchdk1? NEnkVnlUSU6JRWK=
EW-22 NE[4bWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LN[GlEPTB;NE[uNkBvVQ>? Mn\KV2FPT0WU
NCI-H1355 NGj3XmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3hendVUUN3ME20Ok4{PCCwTR?= MXfTRW5ITVJ?
DOHH-2 MkjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELjco5KSzVyPUS2MlM4KG6P MWjTRW5ITVJ?
A4-Fuk MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;0b45KSzVyPUS2MlUzKG6P M3\OfHNCVkeHUh?=
PC-14 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPaTWM2OD12Nj61O{BvVQ>? Mk\hV2FPT0WU
TE-5 M1zRZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYn6dHIyUUN3ME20Ok45PCCwTR?= MYPTRW5ITVJ?
LB996-RCC MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGi4ephKSzVyPUS3MlE6KG6P MVrTRW5ITVJ?
NCI-H1623 NUXaOlU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7BTWM2OD12Nz63OkBvVQ>? MkCyV2FPT0WU
NCI-H1155 NGfvTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\PT2lEPTB;NEiuN|Ihdk1? MX3TRW5ITVJ?
LoVo NVnQPFA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\H[|RKSzVyPUS4MlQhdk1? M3LGbHNCVkeHUh?=
MCF7 M1Ll[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SxWGlEPTB;NEiuOVghdk1? NHjlRYlUSU6JRWK=
AGS MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nw[GlEPTB;NEiuO|chdk1? NEjLWFlUSU6JRWK=
PFSK-1 NWrFPZJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHBTWM2OD12OT6wOkBvVQ>? Mom1V2FPT0WU
22RV1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHHTGRKSzVyPUS5MlA6KG6P M4DoNHNCVkeHUh?=
COR-L23 NFO5fnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr6cmlKSzVyPUS5MlE3KG6P NFrZS2lUSU6JRWK=
D-283MED NF\TUmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\xT2lEPTB;NEmuOlEhdk1? M{TyWHNCVkeHUh?=
SW982 NVP0OXRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXYS2NHUUN3ME20PU46OSCwTR?= MUfTRW5ITVJ?
SW620 NWGxNJlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTVyLkO2JI5O Ml3yV2FPT0WU
KYSE-140 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C0N2lEPTB;NUCuOVUhdk1? MWPTRW5ITVJ?
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MHH-ESS-1 NUf6S3VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXleIdKSzVyPUWxMlk2KG6P M17PcXNCVkeHUh?=
D-423MG NIPjfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfDNYU2UUN3ME21Nk4xQCCwTR?= NV\ST2FyW0GQR1XS
SF539 MkSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe5dFlQUUN3ME21Nk4{PSCwTR?= NGPNXZlUSU6JRWK=
RPMI-2650 NEWwUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf4TWM2OD13Mj62PUBvVQ>? NV\NSIZEW0GQR1XS
GR-ST MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LaXGlEPTB;NUKuPFchdk1? M3vHeHNCVkeHUh?=
YKG-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTV|IH7N NU\1R|JyW0GQR1XS
SK-MES-1 M2jGWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDpflJ4UUN3ME21N{4zPiCwTR?= NWjmNWR[W0GQR1XS
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RVH-421 MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17PfmlEPTB;NUOuOlchdk1? NHjwWVdUSU6JRWK=
C32 NXzTSXpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\PR5BKSzVyPUWzMlg{KG6P NGLuR5BUSU6JRWK=
GB-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;QNmlEPTB;NUSuNkBvVQ>? MUfTRW5ITVJ?
SNB75 NHfMT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vySmlEPTB;NUSuNlYhdk1? MmX5V2FPT0WU
EM-2 M4fmdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfVeZhKSzVyPUW0MlQhdk1? NVjZeZA3W0GQR1XS
RH-1 M13Gdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLSW|NKSzVyPUW0Mlchdk1? MnrJV2FPT0WU
NKM-1 M4K5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjDRld2UUN3ME21OE45OSCwTR?= MV\TRW5ITVJ?
NCI-H2405 NXrnO3BqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1e3[mlEPTB;NUSuPFghdk1? MUTTRW5ITVJ?
KYSE-450 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7uTWM2OD13NT6xOkBvVQ>? NEjmRXBUSU6JRWK=
A704 NXrCdXhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTqTWM2OD13NT61PUBvVQ>? M1LV[XNCVkeHUh?=
HAL-01 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjlNJVPUUN3ME21OU45OyCwTR?= MUPTRW5ITVJ?
TE-11 Ml3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jM[2lEPTB;NUWuPVkhdk1? M{fYSXNCVkeHUh?=
DOK MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTV4LkCyJI5O M{noXHNCVkeHUh?=
KY821 M{\1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XWNWlEPTB;NU[uNkBvVQ>? NVHEOVFJW0GQR1XS
KGN M1Gx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3pPIVKSzVyPUW2MlMzKG6P MlnEV2FPT0WU
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PANC-08-13 NHnod3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP2cotKSzVyPUW4MlAyKG6P NX;YUYI4W0GQR1XS
KE-37 NYLrZZd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWGwS5FtUUN3ME21PE44PyCwTR?= MUjTRW5ITVJ?
KYSE-410 NGXWVplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrIfG5KSzVyPUW5MlQ4KG6P Mki3V2FPT0WU
RO82-W-1 NHzYfmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3nbIZKSzVyPUW5Mlkhdk1? MoewV2FPT0WU
M14 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[2UnRNUUN3ME22NE4xPCCwTR?= NYnSTHVlW0GQR1XS
GI-1 NFntTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTZyLkOgcm0> MYLTRW5ITVJ?
ML-2 NHzheIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml24TWM2OD14MD62NkBvVQ>? NHHmZVFUSU6JRWK=
BFTC-905 NV7hR2ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnHfIw5UUN3ME22NE43PSCwTR?= NFKxVJlUSU6JRWK=
DMS-273 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TTfGlEPTB;NkCuPFchdk1? MlrwV2FPT0WU
MDA-MB-361 M2[1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPB[4NCUUN3ME22NUBvVQ>? MoXJV2FPT0WU
MSTO-211H MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjWTWM2OD14Mz61NUBvVQ>? MnLSV2FPT0WU
MEG-01 M4npdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnhPIlKSzVyPU[zMlUzKG6P NXzHbo1DW0GQR1XS
M059J NYPnVW1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;ObmlEPTB;NkOuOVghdk1? NVLxWmpMW0GQR1XS
LN-405 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr3fVFKSzVyPU[zMlg2KG6P NX62bHczW0GQR1XS
NCI-H1581 NE\wTG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTZ2LkCzJI5O NWrCXXN5W0GQR1XS
TCCSUP M{HsXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DqNWlEPTB;NkSuOVMhdk1? NHn4Z4NUSU6JRWK=
SW872 NXzjc4ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTZ2LkW3JI5O NUD1UmdyW0GQR1XS
KYSE-510 Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTZ3Lke1JI5O MWPTRW5ITVJ?
NCI-H1792 NHjBbFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITCb|lKSzVyPU[2MlE2KG6P M4DsVHNCVkeHUh?=
SW13 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3kW|F3UUN3ME22Ok42KG6P NEfpO2VUSU6JRWK=
TE-8 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTyTWM2OD14Nj61NkBvVQ>? M4\iXnNCVkeHUh?=
SCH MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTZ5LkGgcm0> NXf0fJppW0GQR1XS
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HuO-3N1 M1rOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LhOWlEPTB;NkeuN|Ehdk1? M3nLd3NCVkeHUh?=
EFM-19 Mk\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTmTWM2OD14Nz61JI5O NF31OnFUSU6JRWK=
HEC-1 M1vlemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1W1emlEPTB;NkeuOVIhdk1? MkHiV2FPT0WU
T47D M16zdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn2TWM2OD14Nz64O{BvVQ>? MnPYV2FPT0WU
SNU-423 M4jxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjHWGRNUUN3ME22O{46QCCwTR?= MWfTRW5ITVJ?
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CaR-1 M4DCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLMTWM2OD14OD6yOUBvVQ>? NXP2TmlxW0GQR1XS
KU812 NVW3[HV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTZ6Lk[5JI5O NFfjZ4dUSU6JRWK=
AM-38 NGCwWnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7B[VZVUUN3ME22PU4{OSCwTR?= NV3Hc|NuW0GQR1XS
KOSC-2 NVjyS|duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlToTWM2OD14OT65O{BvVQ>? MoLLV2FPT0WU
MC-IXC MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfjRpNKSzVyPUewMlA5KG6P MUHTRW5ITVJ?
SCC-4 MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnSTWM2OD15MT6zPEBvVQ>? MnO0V2FPT0WU
Calu-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorrTWM2OD15MT65PEBvVQ>? NYjMZm5OW0GQR1XS
RPMI-8866 M4HBbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTd{LkiyJI5O M2PvbXNCVkeHUh?=
OVCAR-4 NFPES3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;kb2pKSzVyPUezMlM3KG6P MmHzV2FPT0WU
OAW-42 NHfSZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;aZ|hKSzVyPUezMlM6KG6P NGfadJhUSU6JRWK=
ATN-1 M364emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTd|Lki3JI5O MlnjV2FPT0WU
CHP-212 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPDTWM2OD15ND65OUBvVQ>? NHfadpVUSU6JRWK=
C2BBe1 NFHoSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLZVpRKSzVyPUe1MlA{KG6P NEnvcZpUSU6JRWK=
A498 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:2UYhKSzVyPUe1MlE2KG6P NVrPPGZWW0GQR1XS
SH-4 NH3nNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTd3LkKxJI5O NWjDUJNSW0GQR1XS
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PANC-03-27 Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljCTWM2OD15Nj6yOUBvVQ>? MlHGV2FPT0WU
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SK-MEL-2 MnfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{OyOWlEPTB;N{[uO|Uhdk1? M2\JWXNCVkeHUh?=
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CP50-MEL-B M1fLTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq1cI1KSzVyPUe3MlQhdk1? NH;NPGpUSU6JRWK=
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LU-134-A MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPjZ5VKSzVyPUe5MlA{KG6P NV;DO3R3W0GQR1XS
5637 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPadW9KSzVyPUe5MlI{KG6P NUDxR2djW0GQR1XS
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NCI-H358 M2XFVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXHflF[UUN3ME2xMlk2PTB|IN88US=> M1i0OnNCVkeHUh?=
OAW-28 MmXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrvTWM2OD1{LkC2PVE6KM7:TR?= Mm[1V2FPT0WU
C8166 NEnkOZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\pTnNKSzVyPUKuOlM{QTJizszN NIXOT5NUSU6JRWK=
COLO-678 NUX1[IpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\XXGlEPTB;Mj64N|c3QCEQvF2= NHXCblNUSU6JRWK=
SK-N-DZ NUHwVllET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M375[mlEPTB;Mj64OlM5OSEQvF2= NYS2c|R2W0GQR1XS
NCI-H82 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzPNldTUUN3ME2yMlkxOzZ7IN88US=> M3rIeXNCVkeHUh?=
JVM-2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTNwMEOxPFgh|ryP Mnm3V2FPT0WU
SW1116 NHPEO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTTTWM2OD1|LkC1OFEyKM7:TR?= M{i4UXNCVkeHUh?=
MDA-MB-453 NYnWbJloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof5TWM2OD1|LkGwOFM6KM7:TR?= M4r3fnNCVkeHUh?=
Calu-6 NVj4XItLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuxNZF7UUN3ME2zMlE6QTdizszN NGPRVGNUSU6JRWK=
SHP-77 NV\UNFl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTNwNUK4JO69VQ>? NF\Kd3dUSU6JRWK=
Capan-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfxSlRtUUN3ME20MlMzPThzIN88US=> MYnTRW5ITVJ?
SW948 MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP0bGlmUUN3ME20Mlc1Pzd7IN88US=> M2jQOnNCVkeHUh?=
HDLM-2 NG\GeFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mny5TWM2OD13LkC3O|I2KM7:TR?= MYLTRW5ITVJ?
LAN-6 M4CzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTZwMkG0PVUh|ryP MYHTRW5ITVJ?
LU-135 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LkUGlEPTB;Nj60N|A4PyEQvF2= M131eXNCVkeHUh?=
T84 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDRTWM2OD14Lkm4OlQh|ryP Mn;yV2FPT0WU
CAPAN-1 NVvpfHlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTdwNkKyN|Mh|ryP MWrTRW5ITVJ?
SW1417 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTdwOUG3N|Eh|ryP MVnTRW5ITVJ?
BALL-1 NVXX[mZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLrOJdyUUN3ME24MlUxPDB7IN88US=> M4fifHNCVkeHUh?=
HT-29 M1jJPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTDTWM2OD17LkC3OVk6KM7:TR?= NYLXNVVNW0GQR1XS
C3A NX7wW3JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HRZ2lEPTB;OT64PFM6PCEQvF2= MYPTRW5ITVJ?
NCI-H1993 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rGO2lEPTB;MUCuOVA5OSEQvF2= NXnuO45[W0GQR1XS
SK-MEL-1 NX7t[XpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\ZXGpKSzVyPUGxMlYzQDlizszN M{DBbHNCVkeHUh?=
DU-145 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HDZWlEPTB;MUSuOVA2OiEQvF2= NW\TXnJQW0GQR1XS
KP-N-YN NYq4W4VxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTkTWM2OD1zND61NVA{KM7:TR?= NV3ZVWZXW0GQR1XS
CCRF-CEM NWPOcoZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTF2Lke4NFkh|ryP NU\YWVBuW0GQR1XS
ZR-75-30 NEnuVIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmwUnVbUUN3ME2xOk4{OzB|IN88US=> NF\xfHZUSU6JRWK=
A673 M1Picmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnJdWpKSzVyPUKwMlU2ODdizszN MYfTRW5ITVJ?
K-562 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fXcWlEPTB;MkiuOFE5OyEQvF2= MW\TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

プロトコル(参考用のみ)

キナーゼアッセイ:

[1]

+ 展開

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
細胞アッセイ:

[2]

+ 展開
  • 細胞株: HCT116, DLD-1 and SW480 cells
  • 濃度: 0-1 μM
  • 反応時間: 48 hours
  • 実験の流れ:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (参考用のみ)
動物実験:

[1]

+ 展開
  • 動物モデル: Female Harlan athymic nude mice
  • 製剤: NMP/polyethylene glycol 300 (10/90, v/v)
  • 投薬量: 45 mg/kg
  • 投与方法: p.o.
    (参考用のみ)

溶解度 (25°C)

体外 DMF 18 mg/mL (38.33 mM) warming
DMSO 0.01 mg/mL (0.02 mM)
Water <1 mg/mL
体内 NMP+polyethylene glycol 300 (10+90, v+v) 30 mg/mL

* <1 mg/mlは製品が微弱に溶解する或いは溶解しないことを示します。
* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 469.55
化学式

C30H23N5O

CAS No. 915019-65-7
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00620594 Completed Breast Cancer|Advanced Solid Tumors|Cowden Syndrome Novartis Pharmaceuticals|Novartis December 21, 2006 Phase 1
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Patients. Charles Ryan|Novartis Pharmaceuticals|University of California, San Francisco January 2013 Phase 1|Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • 回答:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

PI3K信号経路図

PI3K Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID