BEZ235 (NVP-BEZ235, Dactolisib)

BEZ235 (NVP-BEZ235,Dactolisib)は一種の二重ATP競争性PI3KとmTOR阻害剤で、無細胞試験でp110α/γ/δ/β/mTOR(p70S6K)を抑制する時のIC50値は 4 nM /5 nM /7 nM /75 nM /6 nMそれぞれ分かれます。BEZ235 (NVP-BEZ235,Dactolisib)はT3TopBP1-ER 細胞の中でATRを抑制して、IC50 値が21 nMになって、Akt とPDK1に作用することが弱くなります。臨床2期。

価格 在庫  
USD 138 あり
USD 214 あり

BEZ235 (NVP-BEZ235, Dactolisib) 化学構造
分子量: 469.55

高品質保証

文献中の引用(78)

カスタマーフィードバック(8)

MSDS

製品説明

  • Compare PI3K Inhibitors
    PI3K製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 BEZ235 (NVP-BEZ235,Dactolisib)は一種の二重ATP競争性PI3KとmTOR阻害剤で、無細胞試験でp110α/γ/δ/β/mTOR(p70S6K)を抑制する時のIC50値は 4 nM /5 nM /7 nM /75 nM /6 nMそれぞれ分かれます。BEZ235 (NVP-BEZ235,Dactolisib)はT3TopBP1-ER 細胞の中でATRを抑制して、IC50 値が21 nMになって、Akt とPDK1に作用することが弱くなります。臨床2期。
ターゲット

p110α

p110γ

p110δ

p110β

ATR

IC50

4 nM

5 nM

7 nM

75 nM [1]

21 nM [8]

In vitro試験 BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
Trypanosoma brucei brucei Mn\VRY51cW2rY4LvZolidCCDc4PhfS=> NGHYNYEyQCCq MVLEUXNQ MULBcpRqfHK7cHHuc5NwdWGuIHHjeIl3cXS7IIfpeIghTUN3MDDv[kAxNjByMkWg{txO MWCyOFgxPTl2Nh?=
MCF7 M3TRdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHoVZdDOC5yMT2xNFAh|ryP NUX1Z3B[PDhiaB?= MVnEUXNQ MkjtTWM2OD1yLkezJO69VQ>? NGLpXHMzOzh5MUmwOC=>
HCT116 NWDsRog5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLYfGZTOC5yMT2xNFAh|ryP MYe0PEBp MYXEUXNQ NEH4N|lKSzVyPUGuNVYh|ryP NV3KOJh3OjN6N{G5NFQ>
U87MG NX\2S5RDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXywMlAyNTFyMDFOwG0> NWPub401PDhiaB?= M2PiSmROW09? MY\JR|UxRTFwM{Kg{txO NIO4d44zOzh5MUmwOC=>
HBC4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUGwMlAyNTFyMDFOwG0> MXO0PEBp NFvkNZdNd2diR1m1NF0uQC54MTDN Mn\QNlI{OzZ{NE[=
BSY1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1m4SFAvODFvMUCwJO69VQ>? M1zBSVQ5KGh? MkjyUI9oKEeLNUC9MVgvPDhiTR?= MW[yNlM{PjJ2Nh?=
HBC5 NVPabGoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfoZYVROC5yMT2xNFAh|ryP NF\PSlU1QCCq NFziTJNNd2diR1m1NF0uPy56NzDN M4P2b|IzOzN4MkS2
MCF7 M3rqOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTZNE4xOS1zMECg{txO NV3JWpBVPDhiaB?= M{DyS2xw\yCJSUWwQU05NjF4IF2= M1PWdVIzOzN4MkS2
MDA-MB-231 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYSwMlAyNTFyMDFOwG0> NWG2cGdoPDhiaB?= M3rrS2xw\yCJSUWwQU05NjB7IF2= NVz4VXJ5OjJ|M{[yOFY>
U251 MmCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4W4ZlAvODFvMUCwJO69VQ>? MkDGOFghcA>? NEP5RYRNd2diR1m1NF0uPy54NjDN MkXvNlI{OzZ{NE[=
SF268 NI\OTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDWNE4xOS1zMECg{txO NVHzdmkxPDhiaB?= NF\2[phNd2diR1m1NF0uPy57MjDN MkiwNlI{OzZ{NE[=
SF295 M1HlcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmwMlAyNTFyMDFOwG0> NF6zVXo1QCCq NH:zVVJNd2diR1m1NF0uQC5|MTDN NWnmemtROjJ|M{[yOFY>
SF539 M4\K[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfRNE4xOS1zMECg{txO NUC4b2JTPDhiaB?= Mo\DUI9oKEeLNUC9MVgvPTliTR?= MojYNlI{OzZ{NE[=
SNB75 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXOwMlAyNTFyMDFOwG0> NHzxUZo1QCCq Mk\BUI9oKEeLNUC9MVgvPThiTR?= NUfOfJFKOjJ|M{[yOFY>
SNB78 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjJdpYxNjBzLUGwNEDPxE1? MojmOFghcA>? NInPNllNd2diR1m1NF0uQC54NTDN NVfpcpo1OjJ|M{[yOFY>
HCC2998 NEHKe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fTTVAvODFvMUCwJO69VQ>? M4[1SVQ5KGh? MUfMc4chT0l3ME2tPE4xPSCP NGSxOoszOjN|NkK0Oi=>
KM12 M33qVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOwMlAyNTFyMDFOwG0> MV[0PEBp NGntW4xNd2diR1m1NF0uPy53NDDN M4P6ZlIzOzN4MkS2
HT-29 MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H1SlAvODFvMUCwJO69VQ>? M1;XOlQ5KGh? NH[xZVJNd2diR1m1NF0uPy55NTDN NWHnPXlIOjJ|M{[yOFY>
HCT15 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TJZ|AvODFvMUCwJO69VQ>? NHjaVIU1QCCq NWLpUllwVG:pIFfJOVA:NThwMEOgUS=> NIToSVAzOjN|NkK0Oi=>
HCT116 Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fxe|AvODFvMUCwJO69VQ>? MUK0PEBp M{n4TGxw\yCJSUWwQU04NjZzIF2= NF[2VGQzOjN|NkK0Oi=>
NCI-H23 M3vPNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmi3NE4xOS1zMECg{txO MXq0PEBp MYPMc4chT0l3ME2tO{43PCCP MX2yNlM{PjJ2Nh?=
NCI-H226 NXn4fFB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:wMlAyNTFyMDFOwG0> NWTMSpZZPDhiaB?= NYH3NJRqVG:pIFfJOVA:NThwNESgUS=> M2PPWVIzOzN4MkS2
NCI-H522 NVzmdGR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[wMlAyNTFyMDFOwG0> M3noO|Q5KGh? MXrMc4chT0l3ME2tPE41PSCP M3X3e|IzOzN4MkS2
NCI-H438 NFXUbZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVqwMlAyNTFyMDFOwG0> MoC3OFghcA>? NEPSSnhNd2diR1m1NF0uQC5zMTDN M1H1UFIzOzN4MkS2
A549 M4eyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDMPYNCOC5yMT2xNFAh|ryP NVnE[ZRXPDhiaB?= NFjSc45Nd2diR1m1NF0uQC5yNzDN MnHENlI{OzZ{NE[=
DMS273 M4\pZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[xNE4xOS1zMECg{txO MX[0PEBp NXnGXHJDVG:pIFfJOVA:NTdwOECgUS=> MUOyNlM{PjJ2Nh?=
DMS114 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\udWkxNjBzLUGwNEDPxE1? MVy0PEBp NV:4VWxSVG:pIFfJOVA:NThwM{mgUS=> MWCyNlM{PjJ2Nh?=
LOXIMVI NY\VcI9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV6wMlAyNTFyMDFOwG0> MnfROFghcA>? M3Hrb2xw\yCJSUWwQU05NjZ4IF2= MViyNlM{PjJ2Nh?=
OVCAR3 NYnDb41[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPMW4JyOC5yMT2xNFAh|ryP Mk[3OFghcA>? NEfnfVNNd2diR1m1NF0uQC5zNzDN M2rQeVIzOzN4MkS2
OVCAR4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWCwMlAyNTFyMDFOwG0> NXG1fXFIPDhiaB?= NYrHUI9LVG:pIFfJOVA:NThwNUigUS=> NVrFPZZFOjJ|M{[yOFY>
OVCAR5 M2DaVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjaRnMxNjBzLUGwNEDPxE1? NYjONJYyPDhiaB?= MUfMc4chT0l3ME2tO{42PyCP MlXXNlI{OzZ{NE[=
OVCAR8 MnG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTSbZNWOC5yMT2xNFAh|ryP MYi0PEBp NHnV[2dNd2diR1m1NF0uPy56NDDN NIfOWYQzOjN|NkK0Oi=>
SKOV3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYewMlAyNTFyMDFOwG0> MnrpOFghcA>? NGrOTmdNd2diR1m1NF0uQC52MTDN M3PSeVIzOzN4MkS2
RXF631L MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7teVhGOC5yMT2xNFAh|ryP NX\leVNHPDhiaB?= MkjIUI9oKEeLNUC9MVgvOjFiTR?= M2\QWFIzOzN4MkS2
ACHN M3fQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPlfYU6OC5yMT2xNFAh|ryP MofSOFghcA>? MXvMc4chT0l3ME2tO{46PSCP M3X4elIzOzN4MkS2
St-4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH5NE4xOS1zMECg{txO MWG0PEBp MUjMc4chT0l3ME2tO{41PyCP NILEeoIzOjN|NkK0Oi=>
MKN1 NHHTfmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rsOFAvODFvMUCwJO69VQ>? MnnhOFghcA>? MkP3UI9oKEeLNUC9MVgvPDFiTR?= MWKyNlM{PjJ2Nh?=
MKN7 M{fQfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mme2NE4xOS1zMECg{txO NVHTWoU2PDhiaB?= M{TL[2xw\yCJSUWwQU04NjZ6IF2= NVX6c49zOjJ|M{[yOFY>
MKN28 NGC2bZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWCwMlAyNTFyMDFOwG0> NFLNWng1QCCq M4jTOWxw\yCJSUWwQU04NjB5IF2= NXLFfIhNOjJ|M{[yOFY>
MKN45 NHL3XYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\NdogxNjBzLUGwNEDPxE1? NUHQWZdQPDhiaB?= M{S5eGxw\yCJSUWwQU05NjN2IF2= NUDpNIJOOjJ|M{[yOFY>
MKN74 NGqyfJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7Xb4wxNjBzLUGwNEDPxE1? NHqweVM1QCCq NHflRlNNd2diR1m1NF0uPy52MjDN MoO4NlI{OzZ{NE[=
DU145 NYH4SYVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nVVFAvODFvMUCwJO69VQ>? NWfsUZVLPDhiaB?= NFrxN4VNd2diR1m1NF0uQC5zNjDN MWSyNlM{PjJ2Nh?=
PC3 NV\rfo5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7GNE4xOS1zMECg{txO M2ThVFQ5KGh? MYLMc4chT0l3ME2tPE43PiCP NVjQVphlOjJ|M{[yOFY>
Trypanosoma brucei brucei NHzWOWNHfW6ldHnvckBCe3OjeR?= MmHmNlAxKG6P MYWxNkBp M1PuT2ROW09? NUTLV49iTGWlcnXhd4UhcW5icHjvd5Bpd3SrZInsJIlvd3OrdH;sJJBpd3OyaHH0[UBt\X[nbB?= NWn3VYZyOjR6MEW5OFY>
Trypanosoma brucei brucei MVfGeY5kfGmxbjDBd5NigQ>? MlflNVghcA>? Mn\BSG1UVw>? MU\Jcohq[mm2aX;uJI9nKHKnY3XweI9zNW2nZHnheIVlKGWwZH;jfZRwe2m|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHS{YX7z[oVzemmwIIXweIFs\Q>? M2jmVVI1QDB3OUS2
Trypanosoma brucei brucei NFfTfY5HfW6ldHnvckBCe3OjeR?= NITscZYzODBibl2= NHrz[2cyOiCq NULWZpRbTE2VTx?= MoDsSYZn\WO2IH;uJJNxcGmwZ3;tfYxmcW5ibHX2[Yw> M4DFXFI1QDB3OUS2
Trypanosoma brucei brucei M1S1d2Z2dmO2aX;uJGF{e2G7 NXHnSJVOOjByIH7N NHjQVFUyOiCq MU\EUXNQ MUnF[oZm[3Rib36gdIhwe3CqYYTp[Jlt[2ixbHnu[UBt\X[nbB?= M3HyNFI1QDB3OUS2
UM-UC-3 NWX0[JN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjLV|ZKSzVyPUOxOUBxVQ>? NFv5NXJUSU6JRWK=
SBC-1 NUHV[VJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTd2MjDwUS=> MWPTRW5ITVJ?
MKN1 M2nVV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzCWIRKSzVyPUKuPEBvVQ>? Mn\IV2FPT0WU
NCI-H720 NUHYN3BPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV22bVhRUUN3ME2zMlU4KG6P M3vmRXNCVkeHUh?=
BFTC-909 NV32ZWhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTNwN{Ggcm0> NVzwT41iW0GQR1XS
BPH-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXaTWM2OD12Lke2JI5O NHzVcoJUSU6JRWK=
PC-3 NX3jWodoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXnTWM2OD13LkC5JI5O NEPSRlJUSU6JRWK=
AN3-CA NEL4U5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PTVWlEPTB;NT61OkBvVQ>? NVO5d4NlW0GQR1XS
HN MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PnW2lEPTB;NT65OkBvVQ>? NGLlWmlUSU6JRWK=
HCC2218 NFXa[lJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXKTWM2OD14Lk[xJI5O NXv3W2tKW0GQR1XS
KP-4 M2\3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPqTWM2OD15IH7N NH\YbJRUSU6JRWK=
LU-139 NEOwe2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\FdWlEPTB;Nz63O{BvVQ>? NVHO[GxpW0GQR1XS
ETK-1 MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzRXWdDUUN3ME23Mlg5KG6P NX;xeHBGW0GQR1XS
Ramos-2G6-4C10 NVTRVYdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRThwNEmgcm0> NYHGOpN1W0GQR1XS
MHH-PREB-1 NFPRcmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTlwMUKgcm0> NVH2PVhnW0GQR1XS
DU-4475 NEXCWJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\DOVlRUUN3ME25MlQ1KG6P NV\6[JFkW0GQR1XS
NCI-H1666 M4LQTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rJWGlEPTB;OT63NUBvVQ>? M37NTHNCVkeHUh?=
CAMA-1 MknOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlO2TWM2OD17Lkigcm0> NGrKcI1USU6JRWK=
TYK-nu NH7MU3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTlwOUSgcm0> NHv0dZRUSU6JRWK=
MFE-280 NHz2SZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmS5TWM2OD17Lkm5JI5O MWfTRW5ITVJ?
A549 NHXEWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nRR2lEPTB;MUCuNVQhdk1? MljWV2FPT0WU
769-P MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33KcWlEPTB;MUCuOFQhdk1? M2fDV3NCVkeHUh?=
L-363 NX\G[4dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELqTG9KSzVyPUGwMlY6KG6P NHHE[lBUSU6JRWK=
ES8 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXOTWM2OD1zMD65JI5O M1TYSnNCVkeHUh?=
PA-1 NWL2boZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXO2d2JOUUN3ME2xNU45OiCwTR?= NILBZVlUSU6JRWK=
Mewo MkjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFzLkm5JI5O MlrZV2FPT0WU
HSC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF{LkKxJI5O M17qfXNCVkeHUh?=
H4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\ifWlEPTB;MUKuOlchdk1? MVrTRW5ITVJ?
BB65-RCC NXrzc|hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXzfmFrUUN3ME2xNk44OiCwTR?= M1XNVHNCVkeHUh?=
NCI-H1793 MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvxXGNKSzVyPUGyMlgzKG6P M3vofHNCVkeHUh?=
KARPAS-45 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvtbJVOUUN3ME2xN{42OSCwTR?= NInv[XVUSU6JRWK=
GCT NHP6WVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\sTWM2OD1zMz62PEBvVQ>? MV7TRW5ITVJ?
EoL-1 NGXPe4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXhTWM2OD1zMz65N{BvVQ>? NYPBOmNSW0GQR1XS
LB2241-RCC NXPXZYpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDqeoZKSzVyPUG0MlAyKG6P NVXuOHdxW0GQR1XS
ES5 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvVTWM2OD1zND63OEBvVQ>? MnH2V2FPT0WU
LOXIMVI NXjzWpBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\kWGlEPTB;MUSuPVkhdk1? M2nnO3NCVkeHUh?=
COR-L105 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn22TWM2OD1zNT6wOEBvVQ>? NWTaXoxRW0GQR1XS
P12-ICHIKAWA MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7TTWM2OD1zNT6xJI5O NXvEelB{W0GQR1XS
CHL-1 NF3neIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzETWM2OD1zNT60OUBvVQ>? NUfZdGdmW0GQR1XS
VMRC-RCZ M2\3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPFOFM4UUN3ME2xOU43OyCwTR?= Mo\ZV2FPT0WU
HH NUfKXodvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvwfXZFUUN3ME2xOU44KG6P MV;TRW5ITVJ?
NUGC-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF4LkO0JI5O M2XUS3NCVkeHUh?=
EGI-1 MkO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\EfJM1UUN3ME2xOk41OyCwTR?= NEPjTmpUSU6JRWK=
OS-RC-2 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLmTWM2OD1zNj60O{BvVQ>? M3vkNXNCVkeHUh?=
MOLT-16 NWXBWIx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS4fIFZUUN3ME2xO{4yPSCwTR?= MYDTRW5ITVJ?
NCI-H209 Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTF5LkK5JI5O MXnTRW5ITVJ?
697 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjFTWM2OD1zNz60N{BvVQ>? MU\TRW5ITVJ?
D-56MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTF5Lk[5JI5O NGTQc|ZUSU6JRWK=
VA-ES-BJ NX;ufWxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\IOlJKSzVyPUG3Mlg{KG6P NF33ZXFUSU6JRWK=
EW-16 M13ZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIK1[|dKSzVyPUG4MlA1KG6P MkPSV2FPT0WU
HGC-27 NEX2ZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPBTWM2OD1zOD6wOkBvVQ>? NU\UU453W0GQR1XS
ES7 NUXCRlVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTF6LkC5JI5O MnnQV2FPT0WU
HuH-7 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTF6LkSgcm0> MVjTRW5ITVJ?
BCPAP MoXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nOWWlEPTB;MUiuOlUhdk1? M{HreXNCVkeHUh?=
SW1710 NGTsV2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTF6LkeyJI5O NYLLWodjW0GQR1XS
IST-MEL1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUKxV3NTUUN3ME2xPE44PyCwTR?= M1T2N3NCVkeHUh?=
SF295 M1f5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTF6LkmzJI5O MULTRW5ITVJ?
RPMI-7951 NYTyT3dLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDtTWM2OD1zOT6yPEBvVQ>? NHH1WHRUSU6JRWK=
SF126 M3LDdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjhOHlKSzVyPUG5MlQyKG6P M1XaRXNCVkeHUh?=
GAMG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjRTWM2OD1zOT60PEBvVQ>? MXzTRW5ITVJ?
KNS-81-FD NWrZSXhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPZ[4lIUUN3ME2xPU42PCCwTR?= MmrFV2FPT0WU
RT-112 NXrSUJg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF7Lk[2JI5O NV7Sb3g2W0GQR1XS
DEL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP6SGZKSzVyPUKwMlQ6KG6P MUnTRW5ITVJ?
CGTH-W-1 Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJyLk[zJI5O MnHYV2FPT0WU
HOS MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\rSGlEPTB;MkGuNFYhdk1? NVPoPVBrW0GQR1XS
ES4 NFzGSFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq5TWM2OD1{MT6wPEBvVQ>? NGDCVmhUSU6JRWK=
RXF393 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrhTWM2OD1{MT60OUBvVQ>? M3nL[HNCVkeHUh?=
NCI-H2030 NWSxXJlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTCd3dCUUN3ME2yNU42OiCwTR?= MY\TRW5ITVJ?
YH-13 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;hTWM2OD1{MT64PEBvVQ>? MojoV2FPT0WU
HT-1080 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M361SmlEPTB;MkGuPVMhdk1? NVXMendVW0GQR1XS
NCI-SNU-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPCTWM2OD1{MT65OUBvVQ>? M160bXNCVkeHUh?=
G-402 NFzCOmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJ{LkG2JI5O MWnTRW5ITVJ?
786-0 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXaNHpZUUN3ME2yNk4zQSCwTR?= Mm\TV2FPT0WU
ME-180 NI\mVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj6TWM2OD1{Mj60N{BvVQ>? NHr4UZdUSU6JRWK=
NB69 NFvoNIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fiPWlEPTB;MkKuOVMhdk1? NHXYSpBUSU6JRWK=
J-RT3-T3-5 M3rwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfhTWM2OD1{Mj65OkBvVQ>? NX7xW4NtW0GQR1XS
TGBC1TKB MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS3TWM2OD1{Mz6wOUBvVQ>? MYfTRW5ITVJ?
SW780 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moe3TWM2OD1{Mz6xN{BvVQ>? MnrYV2FPT0WU
MG-63 M3rRUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:ycZNNUUN3ME2yN{41PSCwTR?= MUfTRW5ITVJ?
BV-173 MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJ|Lki3JI5O MVjTRW5ITVJ?
CAL-51 NV:xNGZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zSUWlEPTB;MkOuPFkhdk1? MoS2V2FPT0WU
A375 M1LDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJ|LkmzJI5O MoLZV2FPT0WU
MEL-HO NVfwW|hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJ2LkC0JI5O NUX5RlAyW0GQR1XS
EFO-27 M{LpSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJ2LkOzJI5O M2XjXHNCVkeHUh?=
Hs-578-T NV\U[JZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkexTWM2OD1{ND61PEBvVQ>? NXroW3BtW0GQR1XS
NBsusSR MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnCT2h6UUN3ME2yOE43KG6P MnvXV2FPT0WU
CTB-1 NVvJUGJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTsc2dKSzVyPUK0MlY4KG6P M1HjWnNCVkeHUh?=
FTC-133 M3rnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJ3LkGgcm0> NVyxe5VrW0GQR1XS
MOLT-4 NYDrN4dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfieoxKSzVyPUK1MlEzKG6P M4jhWXNCVkeHUh?=
HO-1-N-1 NXHGWlRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XxWWlEPTB;MkWuNVUhdk1? MlHJV2FPT0WU
ES3 NXKyZ5lRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJ3LkKyJI5O MVHTRW5ITVJ?
TI-73 M{jlPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rSUmlEPTB;MkWuNlghdk1? MYHTRW5ITVJ?
MPP-89 M4PKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PyeWlEPTB;MkWuN|Ihdk1? MWTTRW5ITVJ?
KYSE-150 M1u1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknJTWM2OD1{NT64PUBvVQ>? MmTTV2FPT0WU
LXF-289 NWPLR|N7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\pSWlEPTB;Mk[uNFQhdk1? M3vVPXNCVkeHUh?=
SK-LU-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LMSmlEPTB;Mk[uNVchdk1? M{C4fHNCVkeHUh?=
HOP-92 MnLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K2VWlEPTB;Mk[uOFghdk1? NXHmV2VvW0GQR1XS
HuO9 NEGzc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLMTWM2OD1{Nj63OkBvVQ>? MkD0V2FPT0WU
SW962 M{fLRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJ4Lke2JI5O Mmn4V2FPT0WU
RS4-11 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\BVVM4UUN3ME2yOk46OSCwTR?= M1[4SXNCVkeHUh?=
NCI-H292 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJ5IH7N NX3vPY5nW0GQR1XS
DB NUj2UI1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3mZVZKSzVyPUK3MlM3KG6P NHrvcnZUSU6JRWK=
SW1088 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi3[lh6UUN3ME2yPE4zQSCwTR?= MWjTRW5ITVJ?
A204 M{\ENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHXTWM2OD1{OD60O{BvVQ>? NHzlVnBUSU6JRWK=
A3-KAW Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\OTWM2OD1{OD62OEBvVQ>? MUPTRW5ITVJ?
MV-4-11 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfxRoZKSzVyPUK4Mlchdk1? NXToT|lUW0GQR1XS
ES1 NGXvV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zYTGlEPTB;MkiuPFQhdk1? NVT1cFRSW0GQR1XS
ONS-76 NEm0bVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ7LkC1JI5O MWXTRW5ITVJ?
D-263MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGftc3lKSzVyPUK5MlM2KG6P NXvmUVZDW0GQR1XS
U-2-OS NILPR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ7LkWgcm0> MUjTRW5ITVJ?
T98G M3Twc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvZV285UUN3ME2yPU45QCCwTR?= NFPxb4ZUSU6JRWK=
GI-ME-N NYPJVoE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITy[G1KSzVyPUK5MlkyKG6P NIfIO4VUSU6JRWK=
BHT-101 Mly5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fIV2lEPTB;M{CuNFUhdk1? MlS1V2FPT0WU
NOS-1 M{Htc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTNyLkGyJI5O NH7jbHhUSU6JRWK=
AsPC-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLpZYZCUUN3ME2zNE4zKG6P MYrTRW5ITVJ?
QIMR-WIL MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP2R4lKSzVyPUOwMlYhdk1? MlzEV2FPT0WU
JVM-3 NIrHSGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDLV5Q5UUN3ME2zNE45OyCwTR?= Mmm4V2FPT0WU
KU-19-19 NV3YS3l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVruNZRiUUN3ME2zNU4yOyCwTR?= NXfyUolqW0GQR1XS
OVCAR-8 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTNzLkK2JI5O Mn73V2FPT0WU
BEN NGnOZ4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vrVWlEPTB;M{GuOlMhdk1? NYPRWYF4W0GQR1XS
BE-13 NGXkSnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTNzLkiyJI5O NXHXS|U1W0GQR1XS
EW-18 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjHWm5DUUN3ME2zNU45PiCwTR?= Mn:5V2FPT0WU
ECC10 M3XjO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D3cGlEPTB;M{GuPVUhdk1? M4\6RnNCVkeHUh?=
CTV-1 M1;5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILhWHVKSzVyPUOyMlgzKG6P MkHSV2FPT0WU
COLO-800 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTN{LkmyJI5O MUjTRW5ITVJ?
A2058 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:5dmlEPTB;M{OuNlUhdk1? M4TOZ3NCVkeHUh?=
VM-CUB-1 M1zaUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXjTWM2OD1|Mz60N{BvVQ>? MV3TRW5ITVJ?
Ca9-22 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXLdVFLUUN3ME2zN{42PSCwTR?= MkXwV2FPT0WU
COLO-684 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTN|LkW4JI5O M{LLfXNCVkeHUh?=
RPMI-8226 Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;IdYJKSzVyPUOzMlgzKG6P NETVe5pUSU6JRWK=
SK-NEP-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLkTWM2OD1|ND6xOUBvVQ>? MWXTRW5ITVJ?
Becker NXvzUGVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTN2LkKxJI5O M3f2TnNCVkeHUh?=
NCI-H28 NHS0VphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;mVJZmUUN3ME2zOE41PCCwTR?= NXjafGR{W0GQR1XS
CAL-120 Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTN2LkeyJI5O MWPTRW5ITVJ?
MDA-MB-157 MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm5cpJmUUN3ME2zOU41OSCwTR?= NELzNnZUSU6JRWK=
OVCAR-5 NUn4c4ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfnTWM2OD1|NT60O{BvVQ>? M{HPfHNCVkeHUh?=
LAMA-84 Mo\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTN3Lki3JI5O M2rJN3NCVkeHUh?=
CAKI-1 M2DzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTN4LkSzJI5O MoT0V2FPT0WU
Daoy M2O5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXYTWM2OD1|Nj63JI5O M4fHVXNCVkeHUh?=
CAL-62 M3H6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfpZpZKSzVyPUO2Mlg3KG6P MkjVV2FPT0WU
8-MG-BA NUixbGh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPpTWM2OD1|Nz6yOUBvVQ>? M{ew[XNCVkeHUh?=
8505C M4mweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;scGlEPTB;M{euOVEhdk1? NGTDcpBUSU6JRWK=
LNCaP-Clone-FGC NIjGZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DlNmlEPTB;M{euOVkhdk1? MYXTRW5ITVJ?
CAL-39 M1zvOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLYZWtEUUN3ME2zO{46KG6P M3HOOXNCVkeHUh?=
MN-60 Mm\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTN5Lkm2JI5O NYXOSG53W0GQR1XS
RKO M3vwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\Uc2psUUN3ME2zPE4{OyCwTR?= MWXTRW5ITVJ?
U251 NX\yU|g5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTN6LkSzJI5O MofwV2FPT0WU
SJSA-1 M{jqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXCUVRJUUN3ME2zPE42PCCwTR?= NFXNNHNUSU6JRWK=
CAL-12T NWrmUndkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K0WWlEPTB;M{iuOkBvVQ>? NGfuU2RUSU6JRWK=
HCC1419 M1nXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTN6LkexJI5O M3KyfXNCVkeHUh?=
CO-314 M4KxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXzTWM2OD1|OD63OEBvVQ>? NILHOHRUSU6JRWK=
LB1047-RCC NFHPS5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zxSWlEPTB;M{iuPFEhdk1? MnP2V2FPT0WU
A101D NWftTW1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXm[2JKSzVyPUO4Mlk4KG6P NXLYOJFkW0GQR1XS
MDA-MB-175-VII MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHhe2J[UUN3ME2zPU42OSCwTR?= MVrTRW5ITVJ?
MZ2-MEL MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\wTWM2OD1|OT62OkBvVQ>? NF7yfJJUSU6JRWK=
NB5 M4HRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjzTWM2OD12MD62OEBvVQ>? NUe2fpJlW0GQR1XS
G-401 MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTRyLkiyJI5O NHjsTJVUSU6JRWK=
HT M2TmNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G1N2lEPTB;NEGuNFIhdk1? M2PFfHNCVkeHUh?=
8305C NH\nNJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKyTWM2OD12MT64O{BvVQ>? MXvTRW5ITVJ?
BHY MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPWTWM2OD12Mj63NkBvVQ>? NGH5bW9USU6JRWK=
NTERA-S-cl-D1 NIXYWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTR|IH7N NUHUdYtjW0GQR1XS
T-24 MnPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;ZUZFKSzVyPUSzMlg{KG6P NUjjRlhuW0GQR1XS
EPLC-272H MnfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjvWGtIUUN3ME20OE4{QSCwTR?= MlH6V2FPT0WU
PSN1 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPqfplKSzVyPUS0MlQhdk1? NWfjVodMW0GQR1XS
NCI-H2452 M3vQbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjueHJKSzVyPUS0MlU5KG6P NIezVppUSU6JRWK=
KS-1 NIOxeI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvUTWM2OD12ND62OkBvVQ>? Mmr6V2FPT0WU
HD-MY-Z MmT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGi5dW1KSzVyPUS0MlkzKG6P NFHoS4lUSU6JRWK=
KNS-62 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTR3LkO4JI5O NH;C[ZFUSU6JRWK=
NOMO-1 MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPRTWM2OD12NT64O{BvVQ>? M4XOdHNCVkeHUh?=
SK-HEP-1 M1HIemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTR4LkC0JI5O NIS2SotUSU6JRWK=
IGR-1 Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILDXlNKSzVyPUS2MlE{KG6P MWnTRW5ITVJ?
KYSE-180 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LNWmlEPTB;NE[uNVchdk1? Ml71V2FPT0WU
EW-22 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTR4LkKgcm0> NF32NmZUSU6JRWK=
NCI-H1355 Ml;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjDdHlKSzVyPUS2MlM1KG6P MXPTRW5ITVJ?
DOHH-2 M3f1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW1TWM2OD12Nj6zO{BvVQ>? Mmf0V2FPT0WU
A4-Fuk MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjjUpVKSzVyPUS2MlUzKG6P NW\y[5ZrW0GQR1XS
PC-14 NWGyZZNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnJTWM2OD12Nj61O{BvVQ>? NWroUI5nW0GQR1XS
TE-5 M1q4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7TTWM2OD12Nj64OEBvVQ>? MYHTRW5ITVJ?
LB996-RCC NHvCVZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrTTWM2OD12Nz6xPUBvVQ>? NULCZpRYW0GQR1XS
NCI-H1623 NWC4VHZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTR5Lke2JI5O MmLuV2FPT0WU
NCI-H1155 NVPObVczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYOwUnIzUUN3ME20PE4{OiCwTR?= NFXWW3ZUSU6JRWK=
LoVo M2XwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHueWt4UUN3ME20PE41KG6P MoDHV2FPT0WU
MCF7 NEfkS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTR6LkW4JI5O M1zLcHNCVkeHUh?=
AGS NGPqXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm4PXVKSzVyPUS4Mlc4KG6P NWDIcWdIW0GQR1XS
PFSK-1 NWfh[XdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fUOmlEPTB;NEmuNFYhdk1? MXzTRW5ITVJ?
22RV1 MlnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTR7LkC5JI5O MUjTRW5ITVJ?
COR-L23 NYO2PZM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXsdoo1UUN3ME20PU4yPiCwTR?= MlPkV2FPT0WU
D-283MED NEnMOVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPmTWM2OD12OT62NUBvVQ>? M4nMbnNCVkeHUh?=
SW982 M33UOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3RVmtZUUN3ME20PU46OSCwTR?= MoHRV2FPT0WU
SW620 MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTuTWM2OD13MD6zOkBvVQ>? NFWxT5NUSU6JRWK=
KYSE-140 NWKwVoRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XIW2lEPTB;NUCuOVUhdk1? Moe3V2FPT0WU
GCIY Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7TTWM2OD13MD62O{BvVQ>? Mn7pV2FPT0WU
MHH-ESS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XCZmlEPTB;NUGuPVUhdk1? MlHLV2FPT0WU
D-423MG NGXoTpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTV{LkC4JI5O NHH3UoRUSU6JRWK=
SF539 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXiydncxUUN3ME21Nk4{PSCwTR?= NYW0dGN5W0GQR1XS
RPMI-2650 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrMWI1WUUN3ME21Nk43QSCwTR?= NXLGe4h6W0GQR1XS
GR-ST NWjvc2wxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf0NYlKSzVyPUWyMlg4KG6P MnXNV2FPT0WU
YKG-1 NGfmNm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF23RlhKSzVyPUWzJI5O NG\BV5pUSU6JRWK=
SK-MES-1 NFG2bXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfqcXRKSzVyPUWzMlI3KG6P Mme0V2FPT0WU
HLE NV3ocFB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTV|LkS3JI5O MUDTRW5ITVJ?
RVH-421 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fTdGlEPTB;NUOuOlchdk1? NXjGeZRGW0GQR1XS
C32 M1PLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrSTWM2OD13Mz64N{BvVQ>? Mk\5V2FPT0WU
GB-1 NVnVclA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHXTWM2OD13ND6yJI5O MorUV2FPT0WU
SNB75 MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TRPGlEPTB;NUSuNlYhdk1? MlzoV2FPT0WU
EM-2 MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjZTWM2OD13ND60JI5O NIHDfW5USU6JRWK=
RH-1 M4DlRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[3WlhKSzVyPUW0Mlchdk1? MoiyV2FPT0WU
NKM-1 Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnhTWM2OD13ND64NUBvVQ>? M1fB[3NCVkeHUh?=
NCI-H2405 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXUR3g4UUN3ME21OE45QCCwTR?= M{P0[HNCVkeHUh?=
KYSE-450 NELGOI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XJN2lEPTB;NUWuNVYhdk1? NVTCSmNKW0GQR1XS
A704 M{nRT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorBTWM2OD13NT61PUBvVQ>? MWjTRW5ITVJ?
HAL-01 M3fhSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfCUHJKSzVyPUW1Mlg{KG6P NVfTSVM3W0GQR1XS
TE-11 NGHHdIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnQTWM2OD13NT65PUBvVQ>? NYPUXXpPW0GQR1XS
DOK MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH74XZVKSzVyPUW2MlAzKG6P MV7TRW5ITVJ?
KY821 M2rWXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTV4LkKgcm0> Mm\2V2FPT0WU
KGN NFHSfW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXoTWM2OD13Nj6zNkBvVQ>? MUDTRW5ITVJ?
MC116 NWG2TVJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33Ue2lEPTB;NUeuPEBvVQ>? NX[5SJVPW0GQR1XS
PANC-08-13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TOV2lEPTB;NUiuNFEhdk1? Mn3kV2FPT0WU
KE-37 NH2wSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7rcVdKSzVyPUW4Mlc4KG6P MXnTRW5ITVJ?
KYSE-410 NIPyfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLCTWM2OD13OT60O{BvVQ>? M2nSNHNCVkeHUh?=
RO82-W-1 M3rTXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPQTWM2OD13OT65JI5O NHzyVHhUSU6JRWK=
M14 NEDhWXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPtTWM2OD14MD6wOEBvVQ>? NVXuOYNoW0GQR1XS
GI-1 M{L5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qybGlEPTB;NkCuN{BvVQ>? MonJV2FPT0WU
ML-2 NIOzbmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnrd|JkUUN3ME22NE43OiCwTR?= NVjTRZZiW0GQR1XS
BFTC-905 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHkVlFKSzVyPU[wMlY2KG6P NGDzTIRUSU6JRWK=
DMS-273 MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPBPWpKSzVyPU[wMlg4KG6P NGflT5dUSU6JRWK=
MDA-MB-361 Mle0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTZzIH7N NHPFcoVUSU6JRWK=
MSTO-211H NELQTo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTZ|LkWxJI5O MoTkV2FPT0WU
MEG-01 NFPRRYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULlb4ZVUUN3ME22N{42OiCwTR?= NGrLcGtUSU6JRWK=
M059J NW\Rdnc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjudnA6UUN3ME22N{42QCCwTR?= MV;TRW5ITVJ?
LN-405 NYDOeVdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T3XGlEPTB;NkOuPFUhdk1? NYjB[3FLW0GQR1XS
NCI-H1581 NYrWW3h7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\jdmlEPTB;NkSuNFMhdk1? MXjTRW5ITVJ?
TCCSUP MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTZ2LkWzJI5O M3\QSHNCVkeHUh?=
SW872 MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTZ2LkW3JI5O NULLe3p4W0GQR1XS
KYSE-510 NGqyemFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH2wS4hKSzVyPU[1Mlc2KG6P MlnkV2FPT0WU
NCI-H1792 NEW4Tm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrlTWM2OD14Nj6xOUBvVQ>? NHnUbndUSU6JRWK=
SW13 NWnMPYxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDJTWM2OD14Nj61JI5O MVPTRW5ITVJ?
TE-8 MnnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\hTWM2OD14Nj61NkBvVQ>? NG\4V|FUSU6JRWK=
SCH NUH0XYU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXqTWM2OD14Nz6xJI5O MXHTRW5ITVJ?
NEC8 NHnmU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml61TWM2OD14Nz6yOEBvVQ>? NHvOV3VUSU6JRWK=
HuO-3N1 M3rudGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnpSnRHUUN3ME22O{4{OSCwTR?= NUnmSZY4W0GQR1XS
EFM-19 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCwTWM2OD14Nz61JI5O NHTQSXJUSU6JRWK=
HEC-1 M2HtV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTZ5LkWyJI5O MV3TRW5ITVJ?
T47D NHXJ[G1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTZ5Lki3JI5O MkTHV2FPT0WU
SNU-423 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:0RoJKSzVyPU[3Mlk5KG6P NEm2O4tUSU6JRWK=
WM-115 NGr2Z5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTZ6LkG0JI5O MmfVV2FPT0WU
CaR-1 M{W1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qxb2lEPTB;NkiuNlUhdk1? M1;wd3NCVkeHUh?=
KU812 MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLp[4FlUUN3ME22PE43QSCwTR?= M3\aVHNCVkeHUh?=
AM-38 M1zoOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\OTGlEPTB;NkmuN|Ehdk1? MWPTRW5ITVJ?
KOSC-2 NUDXN4c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTZ7Lkm3JI5O MkSzV2FPT0WU
MC-IXC MkfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG2WVhtUUN3ME23NE4xQCCwTR?= M4\GR3NCVkeHUh?=
SCC-4 NEj5bYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\UTWM2OD15MT6zPEBvVQ>? NVzTS5dSW0GQR1XS
Calu-3 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDuO5RKSzVyPUexMlk5KG6P NGm2PVRUSU6JRWK=
RPMI-8866 NF;Y[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq2TWM2OD15Mj64NkBvVQ>? M1vhbHNCVkeHUh?=
OVCAR-4 NY\aSplFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M162PGlEPTB;N{OuN|Yhdk1? M1PCZXNCVkeHUh?=
OAW-42 NEDN[G9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjGcYVKSzVyPUezMlM6KG6P MmnDV2FPT0WU
ATN-1 NVHo[WdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTd|Lki3JI5O M4HNPHNCVkeHUh?=
CHP-212 MoS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoT0TWM2OD15ND65OUBvVQ>? MoXwV2FPT0WU
C2BBe1 NUXSVVRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS3dnZKSzVyPUe1MlA{KG6P MkDSV2FPT0WU
A498 NXHse4R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HM[mlEPTB;N{WuNVUhdk1? NWi5XVQ1W0GQR1XS
SH-4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLUSnd4UUN3ME23OU4zOSCwTR?= NYDJNY4xW0GQR1XS
SNU-449 M{DTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTd3Lke5JI5O NX\DR4NoW0GQR1XS
RD MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X5c2lEPTB;N{WuPFYhdk1? MnPXV2FPT0WU
PANC-03-27 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jYZWlEPTB;N{[uNlUhdk1? MWHTRW5ITVJ?
S-117 NYPkXHVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHRTWM2OD15Nj6yO{BvVQ>? MX3TRW5ITVJ?
SK-MEL-2 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jVPGlEPTB;N{[uO|Uhdk1? MofOV2FPT0WU
LK-2 NWe4R403T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[yPJpKSzVyPUe3MlA2KG6P MV\TRW5ITVJ?
CP50-MEL-B NGSwdIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qwXGlEPTB;N{euOEBvVQ>? MnO2V2FPT0WU
647-V MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTd6LkC3JI5O MU\TRW5ITVJ?
LU-134-A M{XmSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[0coN2UUN3ME23PU4xOyCwTR?= M3\rU3NCVkeHUh?=
5637 M1\WNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vINmlEPTB;N{muNlMhdk1? NIX6[WdUSU6JRWK=
NCI-H1437 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWxTWM2OD16MD61JI5O NH3rVXhUSU6JRWK=
NCI-H460 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmX6TWM2OD16MT6yN{BvVQ>? MoDzV2FPT0WU
BxPC-3 NFTuXHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2T5T2lEPTB;OEGuOFYhdk1? MWHTRW5ITVJ?
CAN M3HGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17GfGlEPTB;OEGuPFQhdk1? M3PUVHNCVkeHUh?=
KINGS-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHhNY1KSzVyPUiyMlMzKG6P NHrlToRUSU6JRWK=
OCUB-M MnTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj1TWM2OD16Mj60NUBvVQ>? Mn;qV2FPT0WU
KALS-1 M1TMVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrJWYJKSzVyPUiyMlU1KG6P MljhV2FPT0WU
OCI-AML2 Mmn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTh{Lk[xJI5O MVfTRW5ITVJ?
A253 MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\ae|Z7UUN3ME24Nk43PSCwTR?= NEXlUldUSU6JRWK=
LCLC-97TM1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HneWlEPTB;OEKuPFYhdk1? NF3DNFVUSU6JRWK=
NCI-H520 NIThdW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3GNFA{UUN3ME24N{4xPiCwTR?= NFWxU49USU6JRWK=
P30-OHK MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LOfWlEPTB;OEOuOUBvVQ>? M2rBOXNCVkeHUh?=
SBC-5 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PEb2lEPTB;OEOuOVIhdk1? MWDTRW5ITVJ?
HCE-T NFrGPHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfRTWM2OD16Mz63OEBvVQ>? MnTpV2FPT0WU
JEG-3 Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nQSmlEPTB;OESuNUBvVQ>? M2qyT3NCVkeHUh?=
KG-1 MkKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\mdGlEPTB;OESuNlQhdk1? MkjrV2FPT0WU
MIA-PaCa-2 NU\TV3lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHtSXAyUUN3ME24OE42PCCwTR?= NX3w[Hl4W0GQR1XS
CAL-33 NVXqUpJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTh3LkC4JI5O NXrrb5BsW0GQR1XS
639-V M{H5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTh3LkSyJI5O NGC0dmpUSU6JRWK=
NCI-H1048 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTh4LkOxJI5O MVfTRW5ITVJ?
NCI-H1573 Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn4VnBKSzVyPUi3MlQ5KG6P NFXuU5lUSU6JRWK=
NCI-H2228 NYPpOpF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkG0TWM2OD16OD6yOkBvVQ>? NFvrVolUSU6JRWK=
NB14 MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvaTWM2OD16OD6zJI5O MnrVV2FPT0WU
SCC-25 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT0RYtrUUN3ME24PU45OiCwTR?= M2PGd3NCVkeHUh?=
A431 NInkeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DXWmlEPTB;OEmuPVchdk1? MVfTRW5ITVJ?
SN12C M1mzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\OcmlEPTB;OUCuOlIhdk1? MUfTRW5ITVJ?
HuCCT1 MlHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G3bmlEPTB;OUCuO|Yhdk1? MlPhV2FPT0WU
LS-123 MnXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X2[WlEPTB;OUKuNVghdk1? M4nGXnNCVkeHUh?=
CAL-85-1 NEiyXJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LHWWlEPTB;OUKuOFghdk1? M4rVfnNCVkeHUh?=
ES6 M2C3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYm0WnRzUUN3ME25Nk45OyCwTR?= M4XUXnNCVkeHUh?=
NCI-H650 M3rMfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorLTWM2OD17ND6wPUBvVQ>? NWr5TIhuW0GQR1XS
NCI-H446 NUTlS3I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;pW|JKSzVyPUm1MlEzKG6P NWCzRYZHW0GQR1XS
EW-13 MlXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\oOVdKSzVyPUm1Mlc2KG6P MmnqV2FPT0WU
HSC-2 NUnlTXh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M175TGlEPTB;OUWuPFkhdk1? NYnmS|AyW0GQR1XS
U031 NXTXb4syT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDFXIJKSzVyPUm2Mlc{KG6P NHz4UolUSU6JRWK=
EW-11 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTl4Lki4JI5O M{L4eHNCVkeHUh?=
GAK Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjXe3VKSzVyPUm4Mlk{KG6P MnHnV2FPT0WU
SK-OV-3 MlfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYThU45ZUUN3ME2xNFAvODdibl2= NGLOV2hUSU6JRWK=
OMC-1 M3fUbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\UdHRKSzVyPUGwNE4yQCCwTR?= NUnOfXFNW0GQR1XS
TK10 M3j6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrDPYJKSzVyPUGwNE4zOSCwTR?= M2DHcHNCVkeHUh?=
EKVX M4Xtemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;YTmlEPTB;MUCwMlYhdk1? MUnTRW5ITVJ?
Detroit562 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvBfYNKSzVyPUGwNk4yPyCwTR?= M{fxWXNCVkeHUh?=
SF268 M1LVVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPrVXhEUUN3ME2xNFIvOzRibl2= NYLTR2d5W0GQR1XS
SNU-387 NH2zS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XG[2lEPTB;MUC0MlE4KG6P NG\hUXNUSU6JRWK=
MDA-MB-231 NFLmdJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS1dnl6UUN3ME2xNFUvODZibl2= M1rpPXNCVkeHUh?=
NCI-H1563 NUjHdmlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFyNT6xPEBvVQ>? MmfnV2FPT0WU
D-502MG M{K0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS0XJlKSzVyPUGwOU44KG6P NVXqb25XW0GQR1XS
A2780 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPINmRKUUN3ME2xNFYvPDdibl2= NETWRmNUSU6JRWK=
IA-LM Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17EeWlEPTB;MUC3MlUyKG6P NY\US2VRW0GQR1XS
D-392MG M4P3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPKZ5czUUN3ME2xNFcvPTRibl2= MWHTRW5ITVJ?
MS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LUUGlEPTB;MUC3MlcyKG6P MnL5V2FPT0WU
SW1990 NIHrbnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHZSVV3UUN3ME2xNFgvPTRibl2= M3PLSHNCVkeHUh?=
HEL NVT2SlduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjobnpKSzVyPUGwPU4zQSCwTR?= MV\TRW5ITVJ?
SW1573 NGHLTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj3NoVKSzVyPUGwPU4{OSCwTR?= MlnCV2FPT0WU
SW1783 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfz[GVKSzVyPUGxNE4zOiCwTR?= NYn1fnFFW0GQR1XS
COLO-680N NG\wbGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFzMD63OkBvVQ>? NFuySYtUSU6JRWK=
NCI-N87 M3f6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u1cGlEPTB;MUGxMlA1KG6P MnjaV2FPT0WU
SK-MEL-28 M1\vO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LRRWlEPTB;MUGxMlU2KG6P M2DnU3NCVkeHUh?=
BT-20 NFX6emVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfKSI5ZUUN3ME2xNVIvODFibl2= NH;zd|FUSU6JRWK=
NCI-H1648 NIHKVZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFzMzDuUS=> NXHqfFhlW0GQR1XS
no-11 NU\MToVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTFzMz6yPEBvVQ>? NXrqd5NsW0GQR1XS
MOLT-13 NV;WPJRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFzMz60OEBvVQ>? MWrTRW5ITVJ?
NCI-H2170 NXiyfWJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTFzND61NUBvVQ>? NXmzRYdjW0GQR1XS
HTC-C3 NXXuPG1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHRR2tKSzVyPUGxOk45PSCwTR?= MnjZV2FPT0WU
LU-99A MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTFzNz6yNUBvVQ>? Mn7UV2FPT0WU
HCC2998 M{XjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;qS25KSzVyPUGxO{46OiCwTR?= M4CzcnNCVkeHUh?=
NB13 NXvsOpFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\D[4lXUUN3ME2xNVcvQTlibl2= MV7TRW5ITVJ?
GT3TKB MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvVPXJKSzVyPUGxPE4xQCCwTR?= M1LhTHNCVkeHUh?=
BT-549 NEHZd3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nX[GlEPTB;MUG4Mlk2KG6P M3PROnNCVkeHUh?=
NCI-H747 NIXVWZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDiVINKSzVyPUGxPU4{PCCwTR?= MVrTRW5ITVJ?
EW-1 NHv6UWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF{MD6yJI5O M4T6SHNCVkeHUh?=
LB831-BLC NGTT[IhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m0TmlEPTB;MUKwMlY{KG6P MkLiV2FPT0WU
NMC-G1 M173VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHrTWM2OD1zMkGuNVEhdk1? MX7TRW5ITVJ?
COLO-679 MkXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L4OWlEPTB;MUKyMlE2KG6P M2G5dnNCVkeHUh?=
HL-60 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF{Mz6xJI5O MnXjV2FPT0WU
MKN7 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF{Mz64N{BvVQ>? NWPz[YIzW0GQR1XS
RERF-LC-MS NXy0S5h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHGTWM2OD1zMkSuN|Ehdk1? MXzTRW5ITVJ?
DMS-114 MnnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInHemFKSzVyPUGyOU4xQSCwTR?= M4KwW3NCVkeHUh?=
HuP-T4 NWSwSFVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7tTpk2UUN3ME2xNlYvQTdibl2= NWS2cWFEW0GQR1XS
HCC2157 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF{Nz61JI5O NVK0VGs3W0GQR1XS
SKG-IIIa MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TVcGlEPTB;MUK4Mlghdk1? NHW5VHlUSU6JRWK=
HCT-116 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLJTWM2OD1zM{CuOlQhdk1? NUnlb3hkW0GQR1XS
BB30-HNC NIDnN4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF|MD63PEBvVQ>? M3H4VXNCVkeHUh?=
KYSE-270 M{m3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vwZmlEPTB;MUOwMlg5KG6P NUHLbm55W0GQR1XS
MFM-223 NW\nPFhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHe2VYlKSzVyPUGzNU42OSCwTR?= MX3TRW5ITVJ?
NH-12 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELtfGhKSzVyPUGzNk46QSCwTR?= MkDkV2FPT0WU
U-118-MG Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfiTWM2OD1zM{OuOlIhdk1? NEXpOHRUSU6JRWK=
ESS-1 NXmwO4J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkSzTWM2OD1zM{WuNVghdk1? NWjxeJdsW0GQR1XS
D-247MG M{m2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTF|NT6yNUBvVQ>? NUPIfHp[W0GQR1XS
IGROV-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTF|NT63OkBvVQ>? NYGwNWJ1W0GQR1XS
C-33-A M3;IeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjoPGlkUUN3ME2xN|UvQTdibl2= MoXnV2FPT0WU
NCI-H1693 NWTJenE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTvSHlKSzVyPUGzOk4yOiCwTR?= NUfqdY1zW0GQR1XS
MLMA NUCzRoFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTF|Nj61PEBvVQ>? NVTXZY84W0GQR1XS
SK-N-AS NGXjdZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfxTWM2OD1zM{euNVchdk1? MYjTRW5ITVJ?
NCI-H1755 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H2dGlEPTB;MUO4Mlg2KG6P MmHPV2FPT0WU
CHP-134 NITpcYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjxTWM2OD1zM{muOVUhdk1? MVLTRW5ITVJ?
LS-513 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mke0TWM2OD1zNECuPVEheE1? M{DUfHNCVkeHUh?=
TE-12 NVj6dVlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDnemMzUUN3ME2xOFAvQTNibl2= M1SzbXNCVkeHUh?=
KNS-42 Mnq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWntS3FSUUN3ME2xOFQvOyCwTR?= NIP6UXVUSU6JRWK=
SJRH30 MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H6U2lEPTB;MUS0MlQ1KG6P MVjTRW5ITVJ?
NCI-H1092 NYXwUHR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnm3TWM2OD1zNESuOVIhdk1? NHjOOWVUSU6JRWK=
H-EMC-SS NXnHVHhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjXTWM2OD1zNE[uPFEhdk1? NFPsOI1USU6JRWK=
SK-MEL-3 NVS1S3pwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTF2Nz61OUBvVQ>? MXjTRW5ITVJ?
SK-N-FI M2roWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDqXnRXUUN3ME2xOFcvPTlibl2= M3e5ZnNCVkeHUh?=
NCI-H2126 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLOSW5KSzVyPUG0PE4yPSCwTR?= MVLTRW5ITVJ?
NCI-H1299 NF[wVGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XEcGlEPTB;MUWwMlIzKG6P MXTTRW5ITVJ?
CFPAC-1 M2DIbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnCTWM2OD1zNUCuOlYhdk1? NFfkcXpUSU6JRWK=
NCI-H661 NX3nOWw6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXaeWpKSzVyPUG1NU4zPiCwTR?= MlzpV2FPT0WU
KYSE-70 NXvz[2FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjiTWM2OD1zNUGuO|khdk1? M2X6T3NCVkeHUh?=
SW900 M4Dib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX60[pYzUUN3ME2xOVQvPjVibl2= MnLSV2FPT0WU
Ca-Ski MoPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF3Nj6zPUBvVQ>? MnTqV2FPT0WU
HPAF-II NWXUOVNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTF3Nj60O{BvVQ>? M1vVO3NCVkeHUh?=
LB2518-MEL NH\KfGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF3Nz6xJI5O M{\oS3NCVkeHUh?=
LC-2-ad MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX63Xm5CUUN3ME2xOVgvPjJibl2= NITUSmNUSU6JRWK=
HCC1806 NGjPSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF4Nz64PEBvVQ>? NIfuNHJUSU6JRWK=
UACC-62 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjQTWM2OD1zNkiuNFkhdk1? M4rlT3NCVkeHUh?=
KM-H2 NFLy[JVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnMepFKSzVyPUG3NE42QCCwTR?= NWDLR29uW0GQR1XS
NCI-H2347 MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\vfHZKSzVyPUG3Nk44OiCwTR?= M{TH[HNCVkeHUh?=
SCC-15 M2nqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\lTWM2OD1zN{OuOlYhdk1? MoDCV2FPT0WU
BB49-HNC M1zPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7TO4xKSzVyPUG3N{45OSCwTR?= MV7TRW5ITVJ?
GMS-10 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF5Mz65OEBvVQ>? NEfTVIFUSU6JRWK=
NCI-H2052 NFq5WIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\nTWM2OD1zN{SuPUBvVQ>? MnrNV2FPT0WU
SW626 NHO3OmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrkWYR1UUN3ME2xO|YvODZibl2= MXHTRW5ITVJ?
MDA-MB-415 M3XV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTF5Nj62NUBvVQ>? MVrTRW5ITVJ?
Saos-2 MkXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHTTWM2OD1zN{muN|Uhdk1? MlX1V2FPT0WU
DK-MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGS4PFlKSzVyPUG4NE4{KG6P Mn3pV2FPT0WU
SNU-C2B Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTF6MD63N{BvVQ>? Mnv5V2FPT0WU
A427 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTaXWtIUUN3ME2xPFIvPTdibl2= MoHyV2FPT0WU
KP-N-YS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvUbmNEUUN3ME2xPFUhdk1? MlfkV2FPT0WU
J82 NHOwcIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfUd3hKSzVyPUG4OU4yQCCwTR?= MonWV2FPT0WU
LS-411N M4XuXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\6SHBKSzVyPUG4O{4zQCCwTR?= NEfrSZlUSU6JRWK=
HCC1937 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PPN2lEPTB;MUi3MlQ6KG6P M3LnRXNCVkeHUh?=
OE33 M2rvSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXETWM2OD1zOEiuPVchdk1? MlvPV2FPT0WU
NB7 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXezTWpEUUN3ME2xPFkvQDlibl2= MYXTRW5ITVJ?
SW684 NVLlPZQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\XTWlEPTB;MUm2MlE{KG6P NVuxZ45KW0GQR1XS
HT-144 NIPSflZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTF7Nj6xOUBvVQ>? NFLkSmdUSU6JRWK=
SK-MEL-30 MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;qXWlMUUN3ME2xPVYvOiCwTR?= M163fXNCVkeHUh?=
DBTRG-05MG MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e5cWlEPTB;MUm4MlQ4KG6P MnvMV2FPT0WU
NCI-H1395 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHVZlVxUUN3ME2xPVgvQDVibl2= MkflV2FPT0WU
NCI-H2122 NEPhdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfhTWM2OD1{MECuOVkhdk1? M{PFPHNCVkeHUh?=
no-10 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnqTWM2OD1{MEGuNFQhdk1? NWn2b5A1W0GQR1XS
SW48 NViyTYtUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\LbmRKSzVyPUKwNU4{OSCwTR?= M3\WSHNCVkeHUh?=
NCI-H1650 M3fJZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJyND6wNUBvVQ>? MXrTRW5ITVJ?
MZ1-PC M1zzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{izWGlEPTB;MkC1MlU5KG6P NEPUcXFUSU6JRWK=
U-266 NULmR4RJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJyNT63PUBvVQ>? MVfTRW5ITVJ?
CAS-1 NGfSXWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrvcJd4UUN3ME2yNFcvPDRibl2= NVL0XlNJW0GQR1XS
AU565 MnLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfUNFNKSzVyPUKxNk45OiCwTR?= NIrrdWRUSU6JRWK=
UACC-257 NEi2TGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4W1b2lEPTB;MkGzMlk6KG6P NFOwWItUSU6JRWK=
CAL-27 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\RTWlEPTB;MkG3MlA2KG6P NE\QRWdUSU6JRWK=
NCI-H23 M2jRRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7iOHBRUUN3ME2yNVkvOzNibl2= MUfTRW5ITVJ?
TE-6 M13EbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJzOT62PEBvVQ>? MVTTRW5ITVJ?
TGBC24TKB Mn:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYOxb204UUN3ME2yNlIvOTdibl2= MUPTRW5ITVJ?
TE-1 NIiydlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHjUWV3UUN3ME2yNlIvQDhibl2= NFTHSpRUSU6JRWK=
RCC10RGB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LLRWlEPTB;MkK0MlE6KG6P NXrHeINCW0GQR1XS
NCI-H596 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L1T2lEPTB;MkK4MlIzKG6P MkPsV2FPT0WU
SW954 NFjaNZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHpTWM2OD1{M{OuPFMhdk1? NXHpVndsW0GQR1XS
NCI-H2087 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\kVIM2UUN3ME2yN|QvPTFibl2= NWj5VG9DW0GQR1XS
SK-PN-DW Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq2PFFXUUN3ME2yN|UvOTlibl2= MorHV2FPT0WU
KM12 Mmf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnQSYNiUUN3ME2yN|UvPyCwTR?= MYXTRW5ITVJ?
BT-474 NGHl[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\WbW5DUUN3ME2yN|UvPzNibl2= MVzTRW5ITVJ?
IST-MES1 NVzIWnk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIi0UVVKSzVyPUKzOk42PyCwTR?= MULTRW5ITVJ?
HT-1197 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M160bmlEPTB;MkO4MlA6KG6P NF21bXdUSU6JRWK=
CAL-54 NHXvZVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfYXlRKSzVyPUKzPE41QSCwTR?= MlHrV2FPT0WU
NB10 NEHrNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\jdlRGUUN3ME2yOFAvODZibl2= M4DS[HNCVkeHUh?=
PANC-10-05 Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJ2NT61OkBvVQ>? M1vCbHNCVkeHUh?=
NCI-H522 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\Dc4hKSzVyPUK0PE4{OSCwTR?= NWXTfWttW0GQR1XS
A388 NXTKPG1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH1eWpKSzVyPUK0PU45OiCwTR?= NWm2OVdwW0GQR1XS
GOTO M4fsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rkdGlEPTB;MkWwMlI6KG6P MUfTRW5ITVJ?
KLE MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz4VHZKSzVyPUK1NU45PyCwTR?= MoTzV2FPT0WU
KYSE-520 MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJ3Mj64OkBvVQ>? M2fWdnNCVkeHUh?=
HCE-4 M3mxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJ4Mj61JI5O NYTINIVQW0GQR1XS
KURAMOCHI MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TTUGlEPTB;Mk[1Mlkhdk1? MVfTRW5ITVJ?
HCC38 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XaVGlEPTB;Mk[2MlQ5KG6P NV;mNIVXW0GQR1XS
FADU NEDPPFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJ4Nj62N{BvVQ>? M3;HUHNCVkeHUh?=
CW-2 NHe0V3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq0dpRKSzVyPUK2PU46PiCwTR?= MWLTRW5ITVJ?
L-428 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ5NT6xOUBvVQ>? NX7ZUYxrW0GQR1XS
HCC1569 NIPMdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn6yTWM2OD1{N{WuPFQhdk1? NULtN3JqW0GQR1XS
NCI-H810 NYfOfWRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\SbpNKSzVyPUK3PE4{OSCwTR?= NGrjc5pUSU6JRWK=
LB771-HNC NUTyWXM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2f4cGlEPTB;Mki1Mlg1KG6P M{LjTHNCVkeHUh?=
LCLC-103H NV3tWIp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvndFlKSzVyPUK4OU46QSCwTR?= MkLyV2FPT0WU
EFO-21 NV21WWdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3K0SGlEPTB;Mki3MlY5KG6P MmjsV2FPT0WU
CAL-72 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjVSplQUUN3ME2yPVMvOTlibl2= M2LxdnNCVkeHUh?=
SCC-9 NX\XVpk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJ7Mz6yNkBvVQ>? M4TyTHNCVkeHUh?=
COLO-829 M4HLTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XnWmlEPTB;Mkm2MlUhdk1? MWPTRW5ITVJ?
U-87-MG MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTNyMD63N{BvVQ>? M4fwUnNCVkeHUh?=
MZ7-mel MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTN{Mz63OkBvVQ>? NIm3Z|VUSU6JRWK=
NCI-H1770 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f1SmlEPTB;M{K2Mlc1KG6P M3TuNHNCVkeHUh?=
ChaGo-K-1 MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnj2TWM2OD1|MkiuNUBvVQ>? NU\3Vm02W0GQR1XS
SiHa M1q3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nLV2lEPTB;M{K5MlI1KG6P M2rxUnNCVkeHUh?=
NCI-SNU-5 M4r0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\2W5VWUUN3ME2zN|YvPzdibl2= MX7TRW5ITVJ?
DJM-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX2wUGNFUUN3ME2zOFAvOzNibl2= MoGzV2FPT0WU
OE19 MnXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vLS2lEPTB;M{SwMlU{KG6P NG\PPHdUSU6JRWK=
NCI-H1651 NXfyS5Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn5dmFKSzVyPUO0OE4yQCCwTR?= MVTTRW5ITVJ?
COLO-792 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzKTWM2OD1|NUSuOFIhdk1? NWjD[JRHW0GQR1XS
ACHN M4\6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTN3Nj63NUBvVQ>? MmDIV2FPT0WU
TH-3 NIfKNVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWyeWVKSzVyPUO3PU46PSCwTR?= M{j6UHNCVkeHUh?=
HT-1376 NH\uXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j3VGlEPTB;M{i0Mlg5KG6P Mn3zV2FPT0WU
RH-18 NWH5[oFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHid|VKSzVyPUO5OE44PCCwTR?= MlLHV2FPT0WU
NB6 NXL5VnFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDsTWM2OD1|OU[uOlYhdk1? MnXVV2FPT0WU
COLO-320-HSR M3jpOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTvS|lEUUN3ME20NFMvOzdibl2= NGLtR2pUSU6JRWK=
UACC-893 NGDTcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTRyNj60O{BvVQ>? MWDTRW5ITVJ?
DSH1 MlSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTRyNj65NUBvVQ>? NW\rToEzW0GQR1XS
TE-10 M{XaS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnOSWZKSzVyPUSwO{4xOSCwTR?= MYXTRW5ITVJ?
HCC70 MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTRyOT6yNUBvVQ>? Mle5V2FPT0WU
TGBC11TKB NH;qWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTRzMD6zN{BvVQ>? MYfTRW5ITVJ?
NCI-H727 M1PMTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfCem9WUUN3ME20NVIvOTFibl2= NWrSdnRXW0GQR1XS
ALL-PO NIHqUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTRzNT62PUBvVQ>? MnvaV2FPT0WU
ABC-1 NU[zPWFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Txb2lEPTB;NEKwMlQ2KG6P M1K1PXNCVkeHUh?=
NCI-H69 MnjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrWTWM2OD12Mk[uO|Yhdk1? MmLZV2FPT0WU
GP5d Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDzTWM2OD12M{SuOFEhdk1? MnPVV2FPT0WU
UMC-11 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH6Uo9TUUN3ME20OVgvOzZibl2= MojZV2FPT0WU
RMG-I MkTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXxTWM2OD12NkeuOVYhdk1? MYjTRW5ITVJ?
YAPC MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPZNY57UUN3ME20PVAvPiCwTR?= MULTRW5ITVJ?
LS-1034 M3u2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzpdZdKSzVyPUS5NU4xPiCwTR?= NHzUUpRUSU6JRWK=
RCM-1 MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\xT2lEPTB;NEm2MlY5KG6P MnLyV2FPT0WU
HCC1954 NGW5V4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDaXJNKSzVyPUWxNk42KG6P NFHHRnZUSU6JRWK=
SK-MEL-24 M4rQU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTVzNj61NUBvVQ>? NGrROG9USU6JRWK=
NB12 MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjw[5hKSzVyPUWyPE41OiCwTR?= M{DH[3NCVkeHUh?=
SW756 M1;UXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTV3ND65OkBvVQ>? Mn7NV2FPT0WU
HCC1187 NVX0fWhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHlTWM2OD13N{WuPFMhdk1? M4WxTXNCVkeHUh?=
NCI-H2342 NUD5PWIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[1fVlOUUN3ME21PVAvOzlibl2= MVvTRW5ITVJ?
NCI-H2291 NEXHXndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3XW|hYUUN3ME21PVgvOzFibl2= MmrLV2FPT0WU
OVCAR-3 NWXuOnhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHpOG9KSzVyPUW5PE46PiCwTR?= NUnyUXdqW0GQR1XS
MHH-NB-11 MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTZ{OT6wNUBvVQ>? NYriN2lHW0GQR1XS
SAS MoK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTZ3Mj62O{BvVQ>? NXXaOHdJW0GQR1XS
COLO-824 MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnXTWM2OD14OEmuN|chdk1? MoL1V2FPT0WU
HCC1395 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD0W|NUUUN3ME22PVgvPSCwTR?= M1H4[nNCVkeHUh?=
COLO-668 NU[0OHoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXlfVdKSzVyPUewOk4yKG6P MWDTRW5ITVJ?
NCI-H226 NXHDNXVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XpfWlEPTB;N{C3Mlghdk1? NFHNN21USU6JRWK=
NB17 MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTd{MT63OUBvVQ>? MV;TRW5ITVJ?
SW1463 M1f1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIqyboVKSzVyPUezPU4yQSCwTR?= M1e0TnNCVkeHUh?=
TGW M1vseWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTd4MD6xOUBvVQ>? MV7TRW5ITVJ?
NCI-H526 M3n5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LPWGlEPTB;OEKzMlU{KG6P MkfaV2FPT0WU
COR-L88 NVW1V4VsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTh2OD6xNkBvVQ>? MWLTRW5ITVJ?
NCI-H441 NWXmSGxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv0elBKSzVyPUi5OU4zOiCwTR?= MVnTRW5ITVJ?
NCI-H630 M2jKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jZXGlEPTB;OUGyMlk3KG6P NHziVY1USU6JRWK=
Mo-T MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnztTWM2OD17NEeuPFghdk1? MoPaV2FPT0WU
JAR MmPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW4dpVKSzVyPUm1Ok4zPCCwTR?= MVfTRW5ITVJ?
NCI-H1838 MnSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrjTWM2OD1zLkCyN|g5KM7:TR?= NUfTVYtIW0GQR1XS
DoTc2-4510 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P0SWlEPTB;MT6wO|M4PiEQvF2= MkPMV2FPT0WU
MKN28 Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTFwMEmwNlQh|ryP MlTtV2FPT0WU
HuP-T3 M{HhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwMUG5NFUh|ryP NInrZ5JUSU6JRWK=
TE-9 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFwMUK5O|Mh|ryP Mn74V2FPT0WU
NY NIjSPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv3bVJKSzVyPUGuNVY4QTJizszN NF\GWZhUSU6JRWK=
HT55 M3HhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LVXGlEPTB;MT6zNVM1PCEQvF2= Mk\mV2FPT0WU
SW837 NHHpU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn6UpJ3UUN3ME2xMlMzQTd6IN88US=> M2DnfXNCVkeHUh?=
NCI-H2029 MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDSe2lKSzVyPUGuOFE4QTFizszN MmD1V2FPT0WU
IST-SL1 NYnId4RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFwNESyOEDPxE1? MUXTRW5ITVJ?
COLO-741 NYH1RY1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvlbIJKSzVyPUGuOFk4PzFizszN M174cnNCVkeHUh?=
LU-65 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fvcWlEPTB;MT62NlI1QSEQvF2= NUHpXoJTW0GQR1XS
NCI-H1304 MnXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTWXZhKSzVyPUGuOlU1QThizszN M2LhSnNCVkeHUh?=
KARPAS-299 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfpTWM2OD1zLke5OFc6KM7:TR?= M3W0[3NCVkeHUh?=
NCI-H358 M4Ll[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\qPVFKSzVyPUGuPVU2ODNizszN M2\2XnNCVkeHUh?=
OAW-28 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\MWHVKSzVyPUKuNFY6OTlizszN MUXTRW5ITVJ?
C8166 NYXI[HY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJwNkOzPVIh|ryP NITT[HNUSU6JRWK=
COLO-678 NIDFZ2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXj[3JSUUN3ME2yMlg{PzZ6IN88US=> NWD3cGs5W0GQR1XS
SK-N-DZ MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3VTWM2OD1{Lki2N|gyKM7:TR?= NWXUSnBsW0GQR1XS
NCI-H82 NIjiN29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvBSIlSUUN3ME2yMlkxOzZ7IN88US=> NHL5eIJUSU6JRWK=
JVM-2 NVrRclJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTNwMEOxPFgh|ryP Moq2V2FPT0WU
SW1116 M{XKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDTUYE2UUN3ME2zMlA2PDFzIN88US=> MkXZV2FPT0WU
MDA-MB-453 NXu2cZVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXhV41KSzVyPUOuNVA1OzlizszN NHHpeFBUSU6JRWK=
Calu-6 Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTTTWM2OD1|LkG5PVch|ryP MYLTRW5ITVJ?
SHP-77 MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWewRpdDUUN3ME2zMlUzQCEQvF2= NX:zNWY6W0GQR1XS
Capan-2 MnvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTRwM{K1PFEh|ryP MoPQV2FPT0WU
SW948 M4TXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLPXmoyUUN3ME20Mlc1Pzd7IN88US=> NHfwR29USU6JRWK=
HDLM-2 NHz1PXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{joeGlEPTB;NT6wO|czPSEQvF2= M4e4bHNCVkeHUh?=
LAN-6 M4D2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LQRWlEPTB;Nj6yNVQ6PSEQvF2= NHfIN5hUSU6JRWK=
LU-135 M{K0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jiXGlEPTB;Nj60N|A4PyEQvF2= NF;6Z4hUSU6JRWK=
T84 NGThfYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTZwOUi2OEDPxE1? MVHTRW5ITVJ?
CAPAN-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M175bmlEPTB;Nz62NlI{OyEQvF2= MYPTRW5ITVJ?
SW1417 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\NTWM2OD15LkmxO|MyKM7:TR?= NULrOGNUW0GQR1XS
BALL-1 M13pe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37WU2lEPTB;OD61NFQxQSEQvF2= Ml\FV2FPT0WU
HT-29 M2XZb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTlwMEe1PVkh|ryP NUH1WYp7W0GQR1XS
C3A MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ywPWlEPTB;OT64PFM6PCEQvF2= NWnCcWZsW0GQR1XS
NCI-H1993 M2DWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\JOGlEPTB;MUCuOVA5OSEQvF2= M3\VenNCVkeHUh?=
SK-MEL-1 NWHHbm54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv6V45TUUN3ME2xNU43Ojh7IN88US=> NYfqPYRFW0GQR1XS
DU-145 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nRXGlEPTB;MUSuOVA2OiEQvF2= NEXlZ5ZUSU6JRWK=
KP-N-YN NVzKdYdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mme4TWM2OD1zND61NVA{KM7:TR?= MmXTV2FPT0WU
CCRF-CEM NHjXUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTF2Lke4NFkh|ryP M4HUR3NCVkeHUh?=
ZR-75-30 NWDobmNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jYTWlEPTB;MU[uN|MxOyEQvF2= NYXWU|Q6W0GQR1XS
A673 Mk[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jQcGlEPTB;MkCuOVUxPyEQvF2= Mn6yV2FPT0WU
K-562 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f0Z2lEPTB;MkiuOFE5OyEQvF2= NFTTVnpUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]
臨床試験
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

In vitro Protein Kinase, PI3K, and mTOR Assays PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.

細胞アッセイ:

[2]

細胞株 HCT116, DLD-1 and SW480 cells
濃度 0-1 μM
反応時間 48 hours
実験の流れ

The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.

動物実験:

[1]

動物モデル Female Harlan athymic nude mice
製剤 NMP/polyethylene glycol 300 (10/90, v/v)
投薬量 45 mg/kg
投与方法 p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download BEZ235 (NVP-BEZ235, Dactolisib) SDF
分子量 469.55
化学式

C30H23N5O

CAS No. 915019-65-7
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMF 18 mg/mL warming (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water <1 mg/mL
In vivo NMP+polyethylene glycol 300 (10+90, v+v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

文献中の引用 (78)

Frequently Asked Questions

  • Question 1
    With difficulties in dissolving BEZ235, How can I improve its solubility?

    Answer: For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related PI3K 阻害剤

  • GDC-0032

    GDC-0032は一種有効的で、次世代のβ亜型PI3K阻害剤で、PI3Kα/δ/γに作用する時のIC50値が0.29 nM/0.12 nM/0.97nMそれぞれ分かれます。GDC-0032はPI3Kα/δ/γに作用する選択性はPI3Kβに作用する選択性より10倍以上が高くなります。

    Features:A beta isoform-sparing PI3K inhibitor.

  • Pilaralisib (XL147)

    Pilaralisib (XL147)は一種の選択性的で、可逆なI型PI3K阻害剤で、無細胞試験でPI3Kα/δ/γに作用する時のIC50値が39 nM/36 nM/23 nMそれぞれに分かれて、PI3Kβに低い作用をしています。臨床1/2期。

  • GNE-317

    GNE-317は一種の有効な大脳浸透性のPI3K阻害剤です。

  • PI-3065

    PI-3065は一種の選択性p110δ阻害剤で、IC50値が15 nMです。PI-3065は選択性について、他のPI3K家族メンバーより70倍以上が高くなります。

  • LY294002

    LY294002は初めの合成で、PI3Kα/δ/βを抑制することが分かった小分子です。無細胞試験で、IC50値は0.5 μM/0.57 μM/0.97 μMそれぞれに分かれます。尚、溶液にの状況はワートマニン(Wortmannin)にの状況よりもっと安定になって、自食胞の形成も遮断できます。

  • 3-Methyladenine (3-MA)

    3-Methyladenine (3-MA)は1種の選択性PI3K阻害剤で、HeLa細胞の中で、Vps34とPI3Kγに作用する時のIC50値は25μMと60μMです。3-Methyladenine (3-MA)はI型PI3Kを永遠に抑制しますが、III型PI3Kを一時に抑制して、自食体の形成も遮断します。

  • CAL-101 (Idelalisib, GS-1101)

    CAL-101 (Idelalisib, GS-1101)は1種のセレクティブp110δ阻害剤です。無細胞試験で、IC50値は2.5 nMです。CAL-101 (Idelalisib, GS-1101)はp110δに表現する選択性はp110α/β/γに表現する選択性 より40-300倍が高くなって、C2β、hVPS34、DNA-PK とmTORに表現する選択性より400-4000倍が高くなります。

  • Wortmannin

    Wortmanninは一種、初めに命名されたPI3K阻害剂で、無細胞試験でIC50値が3 nMになって、PI3K家族に作用する選択性が弱くて、自食体の形成も抑制して、DNA-PK/ATMも有効に抑制して、無細胞試験で、このIC50値が16 nMと150 nMになります。

  • BKM120 (NVP-BKM120, Buparlisib)

    BKM120 (NVP-BKM120, Buparlisib)は1種のセレクティブPI3K阻害剤で、無細胞試験でp110α/β/δ/γに作用する時のIC50値は52 nM/166 nM/116 nM/262 nMそれぞれに分かれます。BKM120 (NVP-BKM120, Buparlisib)はVPS34、mTORとDNAPKに作用する効果が良くなくて、PI4Kβにほとんど活性を表しません。臨床2期。

最近チェックしたアイテム

Tags: BEZ235 (NVP-BEZ235, Dactolisib)を買う | BEZ235 (NVP-BEZ235, Dactolisib)供給者 | BEZ235 (NVP-BEZ235, Dactolisib)を購入する | BEZ235 (NVP-BEZ235, Dactolisib)費用 | BEZ235 (NVP-BEZ235, Dactolisib)生産者 | オーダーBEZ235 (NVP-BEZ235, Dactolisib) | BEZ235 (NVP-BEZ235, Dactolisib)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ