Doxorubicin (Adriamycin) 化学構造
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製品説明

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  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Doxorubicin (Adriamycin) は、DNAトポイソメラーゼIIを妨げて、DNAの損傷とアポトーシスを誘発する抗生エージェントです。
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IC50
In vitro試験 Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
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CCRF-CEM MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLXTWM2OD1{ND61NkBvVQ>? NWmyc2NkW0GQR1XS
SIG-M5 NH;i[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ3Lk[5JI5O NFm4bVFUSU6JRWK=
SK-PN-DW NWn4PGtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvKPHNWUUN3ME2yOU44OiCwTR?= MUjTRW5ITVJ?
SK-HEP-1 NInnWZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnjNW1KSzVyPUK1Mlg3KG6P Mo\IV2FPT0WU
SW620 NWjDTZhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXVfItKSzVyPUK2MlY{KG6P NWXLZoFXW0GQR1XS
HSC-2 NY\GcoN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\zTWM2OD1{Nj63PEBvVQ>? MXXTRW5ITVJ?
CAL-148 NFPhO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLQUVVEUUN3ME2yOk46KG6P Mk\0V2FPT0WU
COLO-205 MlLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJ4Lkm5JI5O MUjTRW5ITVJ?
EoL-1-cell MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi2c|hKSzVyPUK3Mlc5KG6P MYLTRW5ITVJ?
KYSE-150 NV\DXlRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXsTWM2OD1{Nz63PEBvVQ>? NVO3O2RyW0GQR1XS
G-361 MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;XN2F4UUN3ME2yPE45QCCwTR?= NIO3Z2lUSU6JRWK=
PANC-03-27 MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJ6LkG2JI5O MoXIV2FPT0WU
NCI-H2030 NG[yclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjpTWM2OD1{OD6yOkBvVQ>? MV7TRW5ITVJ?
NCI-H441 M2HCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPyTWM2OD1{OD60NkBvVQ>? MU\TRW5ITVJ?
A388 M4Gwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\6fXhKSzVyPUK4MlQ3KG6P MlLGV2FPT0WU
BHY NIP3bXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJ6Lki4JI5O M2XaNnNCVkeHUh?=
KALS-1 MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXaUZoyUUN3ME2yPU4{OyCwTR?= MXfTRW5ITVJ?
NKM-1 MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7SdZBKSzVyPUK5MlQ4KG6P NF7CdodUSU6JRWK=
BB30-HNC Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fmSGlEPTB;MkmuPFUhdk1? NH\xZnpUSU6JRWK=
G-401 MkL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTNyLkKgcm0> NVvOTJFKW0GQR1XS
EW-7 MmD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPITYxKSzVyPUOwMlY{KG6P NHy0SVNUSU6JRWK=
CAN MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTNzLkGyJI5O Ml;5V2FPT0WU
M059J NV\CNJRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj1TWM2OD1|MT6zO{BvVQ>? M2X1b3NCVkeHUh?=
SK-MES-1 M1\Y[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnaPGlDUUN3ME2zNU42KG6P MYXTRW5ITVJ?
5637 NVy0XZBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTNzLki3JI5O NFHjdHpUSU6JRWK=
MKN28 M4rZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjBUZl2UUN3ME2zNU46OSCwTR?= MnLQV2FPT0WU
COR-L23 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXm1fmZyUUN3ME2zNU46PiCwTR?= M{P6RXNCVkeHUh?=
CAL-27 NXXvRWZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXVTWM2OD1|Mj61O{BvVQ>? MX;TRW5ITVJ?
CAL-62 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\5TWM2OD1|Mj63PUBvVQ>? NWjjVGdoW0GQR1XS
C-33-A MlfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTN{Lki5JI5O NXTydZF6W0GQR1XS
RT-112 MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWiwVZN5UUN3ME2zNk46OiCwTR?= M33LOnNCVkeHUh?=
KU812 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PYfGlEPTB;M{OuNlQhdk1? MojLV2FPT0WU
C8166 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[xXYJmUUN3ME2zN{4{OSCwTR?= MYHTRW5ITVJ?
VA-ES-BJ M2G5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHlTWM2OD1|Mz6zOkBvVQ>? MkfNV2FPT0WU
NEC8 M1nEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjNZ3FKSzVyPUOzMlYyKG6P MYTTRW5ITVJ?
EB2 M2DFOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jD[2lEPTB;M{OuO|Mhdk1? M1G4fnNCVkeHUh?=
COLO-680N M325Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LsT2lEPTB;M{OuPFchdk1? NYP6XZRDW0GQR1XS
IGR-1 NIL3blFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTN|LkizJI5O M1\DRXNCVkeHUh?=
MZ2-MEL NEW0e5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHCWIoxUUN3ME2zN{46OiCwTR?= NXHT[VA5W0GQR1XS
MIA-PaCa-2 MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvlVXYxUUN3ME2zOE4zPCCwTR?= NXPwell6W0GQR1XS
IMR-5 M3nie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPoVJUyUUN3ME2zOE43QCCwTR?= NYjTU5BYW0GQR1XS
CHP-212 NUfQPXlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M332e2lEPTB;M{SuPVYhdk1? Mni4V2FPT0WU
CCF-STTG1 M4\zWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTN3LkWgcm0> MUHTRW5ITVJ?
SK-MEL-30 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG4S5BKSzVyPUO1MlYyKG6P MnywV2FPT0WU
HLE MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2O3NmlEPTB;M{WuPEBvVQ>? NV;5cIQ6W0GQR1XS
HOP-62 NX3JNHhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3iwT2lEPTB;M{WuPFghdk1? NIrrcHZUSU6JRWK=
LB1047-RCC Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvkdo5pUUN3ME2zOU46PyCwTR?= MlfmV2FPT0WU
DoTc2-4510 M3TH[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nF[WlEPTB;M{[uNlUhdk1? MnO3V2FPT0WU
HT-29 MmPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37URmlEPTB;M{[uOVchdk1? MoTHV2FPT0WU
HC-1 NYXuc3g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn4fI1KSzVyPUO3MlMzKG6P M2XONnNCVkeHUh?=
TE-5 NUjRXWJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzp[XpKSzVyPUO3MlQ5KG6P M4nLR3NCVkeHUh?=
NCI-H1299 M3rpSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTN5LkW5JI5O M3XrRXNCVkeHUh?=
CHL-1 NUnSfJliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfUdG5KSzVyPUO3Mlc{KG6P MnjtV2FPT0WU
NCI-H2122 NEi4TXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nLNGlEPTB;M{euPUBvVQ>? MnLsV2FPT0WU
DEL MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrITWM2OD1|OD60OEBvVQ>? NEPQdmdUSU6JRWK=
ES5 NFXVeJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7rSWlKSzVyPUO5MlIzKG6P Mkn5V2FPT0WU
CESS MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTN7LkO2JI5O MnX3V2FPT0WU
NCI-H719 NFrtZ5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XTV2lEPTB;M{muOlUhdk1? M3LafHNCVkeHUh?=
A3-KAW NHXzNotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTRyLkG0JI5O M2n4SnNCVkeHUh?=
KP-4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n6VmlEPTB;NECuO|chdk1? NEnHZ21USU6JRWK=
NCI-H358 MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;SRXJ5UUN3ME20NU4xQCCwTR?= MnXYV2FPT0WU
HCC38 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR{LkWgcm0> MXTTRW5ITVJ?
MRK-nu-1 NV3h[2loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPneFUzUUN3ME20N{43PiCwTR?= NWXmS3ZxW0GQR1XS
NCI-H292 NWHtVoVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P1XWlEPTB;NEOuO|Yhdk1? MoeyV2FPT0WU
PA-1 NInCcohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj6OVk{UUN3ME20OE41QCCwTR?= NW\JNo1lW0GQR1XS
CAL-85-1 M1TqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDqbWp1UUN3ME20OE42OiCwTR?= MWLTRW5ITVJ?
KYSE-450 M4Xp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;BTWM2OD12ND63NUBvVQ>? MkS2V2FPT0WU
IST-MEL1 MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e2OmlEPTB;NESuPFQhdk1? NVK2O4d5W0GQR1XS
Ca-Ski M{XKWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfBPFhKSzVyPUS0Mlg1KG6P MlrxV2FPT0WU
OCI-AML2 NHz6UpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGraZYtKSzVyPUS1MlA2KG6P NEjlOZFUSU6JRWK=
NUGC-3 NYXkT5RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof5TWM2OD12NT6yJI5O M1nYcHNCVkeHUh?=
HOS MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TMbmlEPTB;NEWuNlkhdk1? NWTMbmFSW0GQR1XS
NB1 NIHmc|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H6RWlEPTB;NEWuPVkhdk1? MUPTRW5ITVJ?
A253 NV;uR3BrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PHRWlEPTB;NE[uNVIhdk1? MnXQV2FPT0WU
NCI-H209 M1nJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR6LkezJI5O NHTSdXNUSU6JRWK=
MC-CAR MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j4VGlEPTB;NEiuO|Qhdk1? M3LRbHNCVkeHUh?=
NCI-H661 M2XIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DINmlEPTB;NEmuNFMhdk1? NICxdJFUSU6JRWK=
SF295 M2m4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR7LkC4JI5O M1XrcXNCVkeHUh?=
GP5d NHXoNZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z3PGlEPTB;NEmuNVIhdk1? MV7TRW5ITVJ?
P12-ICHIKAWA MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvKTWM2OD12OT6yO{BvVQ>? Mm\iV2FPT0WU
ACHN M2roXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoruTWM2OD12OT6zOEBvVQ>? MonDV2FPT0WU
NCI-H2087 M1;mV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTR7LkSyJI5O MULTRW5ITVJ?
SW48 M4frV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrTbVJKSzVyPUS5MlczKG6P MoGxV2FPT0WU
NCI-H526 NFHnc2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK2ToR{UUN3ME20PU46PiCwTR?= NHW3T3NUSU6JRWK=
Ca9-22 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nwXGlEPTB;NUCuNFchdk1? Ml\TV2FPT0WU
SK-OV-3 M1G3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTVyLkGyJI5O MnzSV2FPT0WU
KYSE-140 MkHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorBTWM2OD13MD60NkBvVQ>? NWfl[mZ{W0GQR1XS
BE-13 M1y5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO0enBKSzVyPUWxMlAzKG6P MoraV2FPT0WU
ES7 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHKxO|FKSzVyPUWxMlQhdk1? NYfscplIW0GQR1XS
IM-9 NYjLbGduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTVzLkSzJI5O M1T5WXNCVkeHUh?=
A101D MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvSclZKSzVyPUWxMlQ5KG6P M2S2TXNCVkeHUh?=
CAPAN-1 NELQRpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XibGlEPTB;NUGuO|Yhdk1? NHW1fnFUSU6JRWK=
NCI-H2009 M3zJ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3qU2hKSzVyPUWxMlc3KG6P MoD1V2FPT0WU
NCI-H522 MoTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTVzLkmzJI5O NHHzWI1USU6JRWK=
HuP-T4 NV30d3ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTGZpZGUUN3ME21Nk4zOiCwTR?= MXXTRW5ITVJ?
BCPAP NIDvXFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnTV2NKSzVyPUWyMlUhdk1? Moj1V2FPT0WU
NCI-H1734 M{DMSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WyUGlEPTB;NUOgcm0> NYW4S|B6W0GQR1XS
SK-LMS-1 MmGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\mOo5KSzVyPUWzMlIzKG6P MnrZV2FPT0WU
CGTH-W-1 MoDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jvTmlEPTB;NUOuOFYhdk1? NULiPIN1W0GQR1XS
RPMI-8402 NEnXPFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLtTWM2OD13Mz64OkBvVQ>? MmPFV2FPT0WU
Calu-3 M1XIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTXTWM2OD13NT65PEBvVQ>? MVrTRW5ITVJ?
COR-L279 M4nSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\TPWNXUUN3ME21Ok46PSCwTR?= Mnm5V2FPT0WU
T84 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;uWGJQUUN3ME21O{4xPiCwTR?= MWfTRW5ITVJ?
P30-OHK MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofFTWM2OD13Nz61O{BvVQ>? M1y5WXNCVkeHUh?=
CHP-126 NHf4blZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTV7LkK0JI5O MY\TRW5ITVJ?
KYSE-180 Mki5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTpTWM2OD13OT63OUBvVQ>? MXjTRW5ITVJ?
CAMG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\0NmlEPTB;NUmuPVYhdk1? NGXLZVRUSU6JRWK=
EW-1 NUjZbWZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzEdWxNUUN3ME22NU4{PSCwTR?= NUT6V2V5W0GQR1XS
OVCAR-8 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTZzLkmyJI5O NFrSZW5USU6JRWK=
HL-60 NYPGVohsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknGTWM2OD14Mj61OkBvVQ>? M{TDO3NCVkeHUh?=
8305C NWHSXWlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETOfXlKSzVyPU[zMlEzKG6P NV2ze|BiW0GQR1XS
IA-LM NFvXeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzSc3ZKSzVyPU[zMlU1KG6P NEDl[JJUSU6JRWK=
HCC2157 NFqxXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3scJhKSzVyPU[zMlk2KG6P NGXv[XhUSU6JRWK=
CTB-1 NVPGcGlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PPZ2lEPTB;NkSwNVkhdk1? MV;TRW5ITVJ?
NCI-H1437 NGPONmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTZ2Lk[0JI5O MWXTRW5ITVJ?
U251 NWiwVFBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTUTWM2OD14ND64PUBvVQ>? M{PVfHNCVkeHUh?=
ALL-PO MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK0PHpKSzVyPU[1MlA{KG6P MVnTRW5ITVJ?
NCI-SNU-1 M3rZcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTZ3Lki2JI5O MYHTRW5ITVJ?
RPMI-6666 NGG3VlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rNO2lEPTB;NkWuPVkhdk1? NVPSTXN7W0GQR1XS
DBTRG-05MG M2fIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2OxemlEPTB;NkeuNVEhdk1? Ml;4V2FPT0WU
PF-382 MlrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfaRmR4UUN3ME22O{4yPyCwTR?= MVjTRW5ITVJ?
GT3TKB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD4c21kUUN3ME22O{4yQSCwTR?= M4XJOHNCVkeHUh?=
SCC-3 NWfIeoVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmWyTWM2OD14Nz6yPEBvVQ>? MkL6V2FPT0WU
LU-134-A MmDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnWTWM2OD14Nz62PEBvVQ>? M3TRZnNCVkeHUh?=
CAL-33 NIjlbndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvYT25KSzVyPU[3Mlg4KG6P MV7TRW5ITVJ?
MC-IXC Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLYTWM2OD14Nz65JI5O M2rPSXNCVkeHUh?=
CPC-N NWHoUXZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1znUGlEPTB;NkiuOEBvVQ>? NUL5VVlOW0GQR1XS
A2780 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLCTWM2OD14OD63PUBvVQ>? M4H1bHNCVkeHUh?=
Daudi M336dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\Sc|lQUUN3ME22PE46PiCwTR?= MX\TRW5ITVJ?
GI-1 NXzpZmRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTZ7Lk[1JI5O MUXTRW5ITVJ?
SW962 NXL4NXVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jMVGlEPTB;NkmuPVUhdk1? Ml63V2FPT0WU
MFE-296 MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7iTWM2OD15MD60PUBvVQ>? MnnGV2FPT0WU
H4 NH;3UJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH36PGRKSzVyPUexMlU3KG6P NEKy[3BUSU6JRWK=
AN3-CA NGj4e2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXEVo1KSzVyPUeyMlMzKG6P MoSyV2FPT0WU
HCC1599 NWTPeVQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLpUWZrUUN3ME23Nk42PCCwTR?= NXXheos{W0GQR1XS
HuCCT1 M{PibGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnXU41KSzVyPUeyMlk{KG6P M2PpV3NCVkeHUh?=
Calu-1 MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\rfGlEPTB;N{OuOkBvVQ>? M4qzVXNCVkeHUh?=
DU-145 NIDzVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH33U4FKSzVyPUezMlc{KG6P Moi1V2FPT0WU
IST-SL2 NYrjTmZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TCcWlEPTB;N{OuPFEhdk1? MYPTRW5ITVJ?
HSC-3 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLUb2ZKSzVyPUe0MlU{KG6P MXTTRW5ITVJ?
HCC1806 Mlz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTd2Lkm2JI5O NEPGTGJUSU6JRWK=
VM-CUB-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzyeWNlUUN3ME23OU4{PiCwTR?= MV3TRW5ITVJ?
HSC-4 M3L4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILFNodKSzVyPUe1Mlc3KG6P MoW3V2FPT0WU
NH-12 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTd4IH7N MWLTRW5ITVJ?
MDA-MB-468 NXi3dnY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHPbotKSzVyPUe2MlE5KG6P Mn;QV2FPT0WU
TUR MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP3VWNKSzVyPUe2MlMzKG6P NYPQN|FXW0GQR1XS
TE-1 NHvQb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nheWlEPTB;N{[uN|Uhdk1? NEXVbmhUSU6JRWK=
CMK NUXVcJZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTFWmNoUUN3ME23O{41OiCwTR?= NX6y[Fg4W0GQR1XS
LB996-RCC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzmVW5KSzVyPUe4MlQ2KG6P NHfEfGVUSU6JRWK=
NCI-H1650 NEW5W5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvzTWM2OD15OD62NkBvVQ>? NF7VS2VUSU6JRWK=
DMS-273 NXXufZV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXxOIVKSzVyPUe4Mlkhdk1? M1zJXHNCVkeHUh?=
NOS-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfIRoh6UUN3ME23PU4yPCCwTR?= M2[3XHNCVkeHUh?=
NB69 NFnqN5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTd7LkKgcm0> MV7TRW5ITVJ?
SUP-T1 MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn5TWM2OD15OT63NkBvVQ>? MWfTRW5ITVJ?
A172 M1GweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEOySGhKSzVyPUiwMlU2KG6P NXj5bIpDW0GQR1XS
TE-12 MlTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TsSGlEPTB;OEGuNFYhdk1? M1XLNXNCVkeHUh?=
MKN45 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDNe|JKSzVyPUixMlUyKG6P MXPTRW5ITVJ?
LoVo MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRThzLkiyJI5O MnvyV2FPT0WU
SW1573 NYDWOHM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTh{LkixJI5O M1vkd3NCVkeHUh?=
ETK-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G4TWlEPTB;OEOuNFEhdk1? MVLTRW5ITVJ?
ABC-1 NYTUNVRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmiyTWM2OD16Mz60OUBvVQ>? M3;nfXNCVkeHUh?=
COLO-668 M3PIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\aTWM2OD16ND60O{BvVQ>? MYTTRW5ITVJ?
UM-UC-3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTh4LkCyJI5O NF7mO|NUSU6JRWK=
BC-1 NFvwUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHoTWM2OD16Nj63OkBvVQ>? MVfTRW5ITVJ?
PANC-10-05 NULpSVhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4f5c2lEPTB;OEiuOFUhdk1? NHPBTGFUSU6JRWK=
ES3 NFzDWYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LZVGlEPTB;OEmuOFghdk1? MkSyV2FPT0WU
TE-441-T NH7nPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7MN2REUUN3ME24PU45OiCwTR?= MVXTRW5ITVJ?
KM-H2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rXXmlEPTB;OUCuOlghdk1? Mn\wV2FPT0WU
SH-4 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPwXXlKSzVyPUmyMlEyKG6P NXPWXmhuW0GQR1XS
SF268 M2Pabmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTl{LkSyJI5O MYjTRW5ITVJ?
VMRC-RCZ NWrhTXF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPrN|h6UUN3ME25N{4zPiCwTR?= MULTRW5ITVJ?
GI-ME-N MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTl|LkOzJI5O MYXTRW5ITVJ?
JEG-3 MmjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPOTWM2OD17NT6xNkBvVQ>? M2rwRnNCVkeHUh?=
J-RT3-T3-5 M1rl[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLaTWM2OD17Nj6zNUBvVQ>? M1nYWHNCVkeHUh?=
K5 NIPheWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPhTFFKSzVyPUm2Mlkhdk1? MoP5V2FPT0WU
EFO-27 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmD1TWM2OD17Nz60OEBvVQ>? NIfpfWxUSU6JRWK=
SW1783 M1PXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTl5Lkm5JI5O NI\2RmVUSU6JRWK=
CAL-39 M3rUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL2TWM2OD17OD6yOEBvVQ>? MYLTRW5ITVJ?
LS-441N NFHTNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;GOZdKSzVyPUm5MlA3KG6P MoHDV2FPT0WU
G-402 NV3tPGI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;aTm5KSzVyPUm5MlA6KG6P MkS1V2FPT0WU
MES-SA MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnkVpVKSzVyPUm5MlU{KG6P MXLTRW5ITVJ?
FADU NF;PWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq5UVFKSzVyPUGwNk4yQCCwTR?= Mm\QV2FPT0WU
DJM-1 M{PlR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjheZhKSzVyPUGwNk4zPSCwTR?= NH[2SpNUSU6JRWK=
SU-DHL-1 M4SyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETsWoNKSzVyPUGwNk42KG6P NYHIfGdHW0GQR1XS
KYSE-410 NI\5OWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\TW5VKSzVyPUGwN{41PiCwTR?= M3TPUnNCVkeHUh?=
NCI-H1618 MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVqxdohmUUN3ME2xNFQvOzVibl2= M{LQS3NCVkeHUh?=
AU565 M1y4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLyd|VjUUN3ME2xNFQvPTFibl2= MXXTRW5ITVJ?
SF126 NI\SS3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFyND61PEBvVQ>? NUCx[WpDW0GQR1XS
MMAC-SF M4nkZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTTbY9KSzVyPUGwOk41QCCwTR?= MWTTRW5ITVJ?
ChaGo-K-1 NF36fYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m3[2lEPTB;MUC3Mlk2KG6P MmXlV2FPT0WU
NCI-H596 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHPVpZkUUN3ME2xNFgvODFibl2= M4fwPHNCVkeHUh?=
LXF-289 MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFyOT6yOEBvVQ>? NE\sflBUSU6JRWK=
HCC1569 NWS5O4h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HaN2lEPTB;MUC5MlM1KG6P M1L5cXNCVkeHUh?=
NCI-H2170 NYXDOVhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3tTWM2OD1zMEmuPVIhdk1? M2fTWXNCVkeHUh?=
ARH-77 NX7GZo0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLRe|NpUUN3ME2xNFkvQTlibl2= MV3TRW5ITVJ?
BOKU M4DJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnSyTWM2OD1zMUCuPFchdk1? MluxV2FPT0WU
SJSA-1 NVTUTFF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG0c5lKSzVyPUGxNU4xPSCwTR?= MUnTRW5ITVJ?
SW626 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfXTWM2OD1zMUGuO|Ehdk1? NGTP[|JUSU6JRWK=
EHEB NUWxTIpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIm5RWJKSzVyPUGxNk42QSCwTR?= NWrjZYxkW0GQR1XS
TE-10 MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDETWlHUUN3ME2xNVIvPjhibl2= MY\TRW5ITVJ?
MZ7-mel MlnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTFzMj64OEBvVQ>? M3i3RnNCVkeHUh?=
SAS NHnObZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLaWFU3UUN3ME2xNVQvPDVibl2= MU\TRW5ITVJ?
TK10 NV3NVXlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PGVmlEPTB;MUG0MlYhdk1? MVnTRW5ITVJ?
SW13 M{\HVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPufIhQUUN3ME2xNVUvOjZibl2= NETLUFVUSU6JRWK=
HCC1937 NUi0S|RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTjSZBKSzVyPUGxOU45PCCwTR?= NHPPZVVUSU6JRWK=
SK-NEP-1 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fI[GlEPTB;MUG2MlI3KG6P NWDGeFl4W0GQR1XS
OVCAR-5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXwTIlDUUN3ME2xNVYvQDFibl2= M3rNO3NCVkeHUh?=
SW837 NVjCUXhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDidY9KSzVyPUGxO{46PSCwTR?= NVXoWGlVW0GQR1XS
BFTC-909 NXr4cWpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXQXnJKSzVyPUGxPE41QCCwTR?= M{\iZ3NCVkeHUh?=
SW872 NGfZWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjQOYtKSzVyPUGyNE45OSCwTR?= MoLlV2FPT0WU
SF539 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXrfIU3UUN3ME2xNlEvPzJibl2= M2jrSnNCVkeHUh?=
MLMA NHrPUIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTF{Mj6wPEBvVQ>? NEDKZZFUSU6JRWK=
BL-41 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HrRWlEPTB;MUKyMlIzKG6P MVXTRW5ITVJ?
LB647-SCLC Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4GxNWlEPTB;MUKzMlM2KG6P M4rJeXNCVkeHUh?=
NCI-H1703 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTF{Nj60NkBvVQ>? MnXZV2FPT0WU
KURAMOCHI MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljqTWM2OD1zMk[uO|Yhdk1? NUDQbG52W0GQR1XS
ATN-1 NWXaSWljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;MTWM2OD1zMkeuO{BvVQ>? NGj5ZXRUSU6JRWK=
SK-CO-1 NV[xSnlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4S4OGlEPTB;MUK5MlIyKG6P MX3TRW5ITVJ?
RPMI-7951 NXXoXHJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK2VI9KSzVyPUGzNE4yPCCwTR?= NHXZOpVUSU6JRWK=
NCI-H1648 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfKR2dKSzVyPUGzNU46PCCwTR?= MnqwV2FPT0WU
NCI-H64 NF7zPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHXTWM2OD1zM{KuOlUhdk1? NE\GSY9USU6JRWK=
HT-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv3bYx4UUN3ME2xN|MvODRibl2= NVLEcXdFW0GQR1XS
NCI-H1770 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETiZlVKSzVyPUGzN{4zOSCwTR?= NIHybYtUSU6JRWK=
NB13 M{Hxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7DdYFKSzVyPUGzOE42PSCwTR?= MXXTRW5ITVJ?
NCI-H747 NV;uPYZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPLXZBKSzVyPUGzOU4xOiCwTR?= MXHTRW5ITVJ?
ML-2 M4Xzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLidZZKSzVyPUGzOU4yPiCwTR?= MoTiV2FPT0WU
CA46 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTF|Nj64PEBvVQ>? NUj5PFVbW0GQR1XS
ES6 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPFTWM2OD1zM{euNVIhdk1? NH3kelFUSU6JRWK=
JiyoyeP-2003 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnrWZhxUUN3ME2xN|cvQCCwTR?= NUm2eFFNW0GQR1XS
NMC-G1 NYj2cmlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\qU5c4UUN3ME2xN|kvOTNibl2= MXXTRW5ITVJ?
U-698-M M2LnO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmS2TWM2OD1zM{muOUBvVQ>? NH\SUFVUSU6JRWK=
LU-99A MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF2Nj61OUBvVQ>? MVvTRW5ITVJ?
NCI-H748 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTF2Nz6zNUBvVQ>? NES2N3VUSU6JRWK=
SK-MEL-3 NV;PZWhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jNVGlEPTB;MUS3MlYyKG6P MmTXV2FPT0WU
SNB75 NGrNZ5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ryNGlEPTB;MUS4MlY2KG6P NVK2UFBCW0GQR1XS
BB65-RCC NFHN[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPUNnh7UUN3ME2xOFkvOzFibl2= NIPRNINUSU6JRWK=
NCI-H1355 NWnyc4RYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\1W2lEPTB;MUWyMlI1KG6P NWC4eXFXW0GQR1XS
SCC-25 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTF3Mz63N{BvVQ>? MXjTRW5ITVJ?
OAW-42 NHHIXXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDjdXZyUUN3ME2xOVMvQDRibl2= MVvTRW5ITVJ?
MONO-MAC-6 NYfGfYx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF3ND6zOkBvVQ>? MnLiV2FPT0WU
WSU-NHL NHrofpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jtdGlEPTB;MUW0MlU5KG6P NGjOSpBUSU6JRWK=
SNU-423 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzSSoRKSzVyPUG1OU4{PCCwTR?= MornV2FPT0WU
SBC-1 MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXn[ldKSzVyPUG1Ok41KG6P Ml\LV2FPT0WU
OVCAR-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF3Nj63PEBvVQ>? MX;TRW5ITVJ?
NCI-H2347 MlH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTF3OD6zOEBvVQ>? NE\1OnRUSU6JRWK=
CAMA-1 MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXTbG41UUN3ME2xOVkvOzNibl2= Mk[4V2FPT0WU
GDM-1 NX3YVYRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELJSJRKSzVyPUG1PU44KG6P NUHpR3kxW0GQR1XS
KNS-81-FD NVjPSmVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XTOGlEPTB;MU[wMlMzKG6P M3rKUXNCVkeHUh?=
no-10 NX;pWHVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTF4MD6zPEBvVQ>? M2XabHNCVkeHUh?=
NCI-H2052 NYrLTYFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXJTWM2OD1zNkCuOFchdk1? NVLHXXdTW0GQR1XS
DB MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF4MT63NUBvVQ>? MV3TRW5ITVJ?
A4-Fuk MmewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF4Mj60PEBvVQ>? M2HScXNCVkeHUh?=
HCE-T Mk\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDTTWM2OD1zNkSuPFchdk1? MWrTRW5ITVJ?
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NCI-H2227 M3PwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\HTWM2OD13LkO2NlMyKM7:TR?= Ml;CV2FPT0WU
DMS-53 NGLSfmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fqRWlEPTB;Nj6xO|ExPiEQvF2= NF\HWlBUSU6JRWK=
LB771-HNC MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrXSlBWUUN3ME22MlQ3QDB4IN88US=> MlTSV2FPT0WU
BB49-HNC MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHUTWM2OD15LkSxO|kyKM7:TR?= NX\uZ|RHW0GQR1XS
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TALL-1 MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;WTWM2OD15Lkm2PFgh|ryP MlXPV2FPT0WU
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P31-FUJ NHn1O25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PiN2lEPTB;NESuN|I5PCEQvF2= M13iXHNCVkeHUh?=
NCI-H524 NV[xTIh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jSTWlEPTB;NEiuPFI1QCEQvF2= NH7EU2ZUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]
臨床試験 A Phase III study of Doxorubicin alone vs. Doxorubicin in combination with TH-302 in subjects with locally advanced unresectable or metastatic soft tissue sarcoma is currently ongoing.
特集

プロトコル (参考用のみ)

動物実験: [1]

動物モデル Female athymic nude mice injected s.c. with MB231 cells
製剤 Dissolved in DMSO, and diluted in saline
投薬量 3 mg/kg/day
投与方法 Delivered intratumorly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Doxorubicin (Adriamycin) SDF
分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管 2年-20℃
6月-80℃in solvent
別名 NSC 123127
溶解度 (25°C) * In vitro DMSO 100 mg/mL warming (172.41 mM)
20 mg/mL (34.48 mM)
エタノール <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (8S,10S)-10-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

文献中の引用 (28)

Frequently Asked Questions

  • Question 1
    Why the IC50 of the compound varied over time in our measurement?

    Answer: Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

技術サポート&よくある質問(FAQ)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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