Doxorubicin (Adriamycin)

Doxorubicin (Adriamycin)は一種の抗生物質試薬ですが、腫瘍細胞の中にDNA topoisomerase IIを抑制し、DNA損傷とアポトーシスを誘導します。

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Doxorubicin (Adriamycin) 化学構造
分子量: 579.98

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製品説明

  • Compare Topoisomerase Inhibitors
    Topoisomerase製品生物活性の比較
  • 研究分野
  • Combination Therapy
    併用療法

製品の説明

生物活性

製品説明 Doxorubicin (Adriamycin)は一種の抗生物質試薬ですが、腫瘍細胞の中にDNA topoisomerase IIを抑制し、DNA損傷とアポトーシスを誘導します。
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IC50
In vitro試験 Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
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Daudi MmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUSyOnFDUUN3ME22PE46PiCwTR?= MYHTRW5ITVJ?
GI-1 NEC4eWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUL6NFhRUUN3ME22PU43PSCwTR?= NHz5eJNUSU6JRWK=
SW962 NFLRcI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUexdW5UUUN3ME22PU46PSCwTR?= M{H3fHNCVkeHUh?=
MFE-296 NGrEVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[4TWM2OD15MD60PUBvVQ>? NFjXUFZUSU6JRWK=
H4 Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX1[5pKSzVyPUexMlU3KG6P MnnaV2FPT0WU
AN3-CA MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jOdGlEPTB;N{KuN|Ihdk1? NWTFfWI{W0GQR1XS
HCC1599 M2jnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXDTWM2OD15Mj61OEBvVQ>? MmPqV2FPT0WU
HuCCT1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTSVZR4UUN3ME23Nk46OyCwTR?= MXXTRW5ITVJ?
Calu-1 NWnPNI9rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnGe3RlUUN3ME23N{43KG6P NVHORW1WW0GQR1XS
DU-145 NU\UUnN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\jU5FKSzVyPUezMlc{KG6P MlOzV2FPT0WU
IST-SL2 MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml6zTWM2OD15Mz64NUBvVQ>? MVLTRW5ITVJ?
HSC-3 NHLaOWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr4WGlKSzVyPUe0MlU{KG6P MVzTRW5ITVJ?
HCC1806 M3viUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnKTWM2OD15ND65OkBvVQ>? M{LFcXNCVkeHUh?=
VM-CUB-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILxPWZKSzVyPUe1MlM3KG6P NFXL[FJUSU6JRWK=
HSC-4 Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfOTWM2OD15NT63OkBvVQ>? MYfTRW5ITVJ?
NH-12 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi3S2hKSzVyPUe2JI5O MmDvV2FPT0WU
MDA-MB-468 M3;0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH6VIczUUN3ME23Ok4yQCCwTR?= NFH3eWNUSU6JRWK=
TUR MoDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17SR2lEPTB;N{[uN|Ihdk1? NHryfoJUSU6JRWK=
TE-1 NVXJZ3A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULKZ4NGUUN3ME23Ok4{PSCwTR?= NFTuboZUSU6JRWK=
CMK MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fMRWlEPTB;N{euOFIhdk1? NULIRXZRW0GQR1XS
LB996-RCC MnXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrBXW9KSzVyPUe4MlQ2KG6P NGPzd3NUSU6JRWK=
NCI-H1650 MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGqxbG5KSzVyPUe4MlYzKG6P NXzWSHA5W0GQR1XS
DMS-273 NILycFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTyTWM2OD15OD65JI5O MlzDV2FPT0WU
NOS-1 NEnXeWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTd7LkG0JI5O MUTTRW5ITVJ?
NB69 NYnpO3U3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTd7LkKgcm0> NWHwWm97W0GQR1XS
SUP-T1 M4\F[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzvOm5oUUN3ME23PU44OiCwTR?= MVvTRW5ITVJ?
A172 NEn3T2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT4c5NKSzVyPUiwMlU2KG6P NIXSWFhUSU6JRWK=
TE-12 NYD6fY1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLJO3lKSzVyPUixMlA3KG6P NYTDVndtW0GQR1XS
MKN45 MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDrXIxKSzVyPUixMlUyKG6P NV3UOG5qW0GQR1XS
LoVo NWHVXJB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmwTWM2OD16MT64NkBvVQ>? NYHjN4x3W0GQR1XS
SW1573 NHm0dZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonnTWM2OD16Mj64NUBvVQ>? MUfTRW5ITVJ?
ETK-1 Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmmxTWM2OD16Mz6wNUBvVQ>? NWHCeGY3W0GQR1XS
ABC-1 NHXOW29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPofoRKUUN3ME24N{41PSCwTR?= NIr2VFlUSU6JRWK=
COLO-668 NFfyd|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W3W2lEPTB;OESuOFchdk1? NGrqeHFUSU6JRWK=
UM-UC-3 MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzrTWM2OD16Nj6wNkBvVQ>? NUj2eFVNW0GQR1XS
BC-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi0T49tUUN3ME24Ok44PiCwTR?= NEPYfZFUSU6JRWK=
PANC-10-05 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG2U3FVUUN3ME24PE41PSCwTR?= MlnwV2FPT0WU
ES3 M2frfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXKNoZUUUN3ME24PU41QCCwTR?= M1HtXHNCVkeHUh?=
TE-441-T NIDCZW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTh7LkiyJI5O MXzTRW5ITVJ?
KM-H2 NULxe4tVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrXdYpwUUN3ME25NE43QCCwTR?= M17ZWXNCVkeHUh?=
SH-4 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrPXWRGUUN3ME25Nk4yOSCwTR?= NGXHUJJUSU6JRWK=
SF268 NWjMPJhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrFUVBKSzVyPUmyMlQzKG6P MVLTRW5ITVJ?
VMRC-RCZ MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvMPGZKSzVyPUmzMlI3KG6P MXnTRW5ITVJ?
GI-ME-N NGjzVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIryOVRKSzVyPUmzMlM{KG6P MoWwV2FPT0WU
JEG-3 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTl3LkGyJI5O M1Lsd3NCVkeHUh?=
J-RT3-T3-5 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\tTWM2OD17Nj6zNUBvVQ>? Mmi2V2FPT0WU
K5 NHPVR2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\TUXR{UUN3ME25Ok46KG6P MWXTRW5ITVJ?
EFO-27 NGDU[ppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC3SpZbUUN3ME25O{41PCCwTR?= MonBV2FPT0WU
SW1783 NF\KWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnSTWM2OD17Nz65PUBvVQ>? MYfTRW5ITVJ?
CAL-39 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrBXWxQUUN3ME25PE4zPCCwTR?= Ml63V2FPT0WU
LS-441N NGe3WHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfWfHhvUUN3ME25PU4xPiCwTR?= MWfTRW5ITVJ?
G-402 NIWw[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjTTWM2OD17OT6wPUBvVQ>? M2i0N3NCVkeHUh?=
MES-SA NIDuOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTl7LkWzJI5O MYLTRW5ITVJ?
FADU MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTFyMj6xPEBvVQ>? M4SxS3NCVkeHUh?=
DJM-1 NGjyRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTFyMj6yOUBvVQ>? MWTTRW5ITVJ?
SU-DHL-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTFyMj61JI5O MYDTRW5ITVJ?
KYSE-410 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4D5TGlEPTB;MUCzMlQ3KG6P MWnTRW5ITVJ?
NCI-H1618 NV7ENY0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTFyND6zOUBvVQ>? MYLTRW5ITVJ?
AU565 NH7zOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTFyND61NUBvVQ>? MmOwV2FPT0WU
SF126 NWLnPVI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PMTmlEPTB;MUC0MlU5KG6P Mn65V2FPT0WU
MMAC-SF M4j3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDF[5NKSzVyPUGwOk41QCCwTR?= MnTFV2FPT0WU
ChaGo-K-1 NV7Dbo56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7OWGZXUUN3ME2xNFcvQTVibl2= NFvNeWVUSU6JRWK=
NCI-H596 MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml25TWM2OD1zMEiuNFEhdk1? NHvSOZVUSU6JRWK=
LXF-289 NHmyS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPPeYl1UUN3ME2xNFkvOjRibl2= MojJV2FPT0WU
HCC1569 M{fKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLkU|NZUUN3ME2xNFkvOzRibl2= M2j1[3NCVkeHUh?=
NCI-H2170 M3y3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGC2OVJKSzVyPUGwPU46OiCwTR?= NUT0RWlKW0GQR1XS
ARH-77 NUjEVplUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXkTWM2OD1zMEmuPVkhdk1? NVXZS5h2W0GQR1XS
BOKU MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTFzMD64O{BvVQ>? NI\Zd5hUSU6JRWK=
SJSA-1 NImyPYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTFzMT6wOUBvVQ>? NWPkfFZ2W0GQR1XS
SW626 NXnwSHZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rCdmlEPTB;MUGxMlcyKG6P M1zqNnNCVkeHUh?=
EHEB NWn2eJh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDCc5NtUUN3ME2xNVIvPTlibl2= NYjIc3hwW0GQR1XS
TE-10 M2e5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTFzMj62PEBvVQ>? NEfsfotUSU6JRWK=
MZ7-mel NFK2cG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn30TWM2OD1zMUKuPFQhdk1? M2rwOnNCVkeHUh?=
SAS MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTncllKSzVyPUGxOE41PSCwTR?= MV7TRW5ITVJ?
TK10 NG[2O2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rNS2lEPTB;MUG0MlYhdk1? MWrTRW5ITVJ?
SW13 NYfI[G9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\u[mFKSzVyPUGxOU4zPiCwTR?= Moe3V2FPT0WU
HCC1937 MoHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fEZWlEPTB;MUG1Mlg1KG6P MXvTRW5ITVJ?
SK-NEP-1 NXe2VldlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zGPWlEPTB;MUG2MlI3KG6P MXHTRW5ITVJ?
OVCAR-5 NWD5OnpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7DV2xbUUN3ME2xNVYvQDFibl2= MoLSV2FPT0WU
SW837 NELEe5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nVdmlEPTB;MUG3Mlk2KG6P Mni3V2FPT0WU
BFTC-909 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmS3TWM2OD1zMUiuOFghdk1? NFfXTZZUSU6JRWK=
SW872 NImxdINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjpW2w4UUN3ME2xNlAvQDFibl2= NYn3bZh5W0GQR1XS
SF539 M3rKR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf0bGtKSzVyPUGyNU44OiCwTR?= MXTTRW5ITVJ?
MLMA MmjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF{Mj6wPEBvVQ>? MX;TRW5ITVJ?
BL-41 NV:0NldFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTF{Mj6yNkBvVQ>? NFzxfYZUSU6JRWK=
LB647-SCLC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTF{Mz6zOUBvVQ>? NIHaNWdUSU6JRWK=
NCI-H1703 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGqwPZRKSzVyPUGyOk41OiCwTR?= MWLTRW5ITVJ?
KURAMOCHI MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXrTWM2OD1zMk[uO|Yhdk1? NYDvS2hnW0GQR1XS
ATN-1 M2HW[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnK4TWM2OD1zMkeuO{BvVQ>? NFTHPVVUSU6JRWK=
SK-CO-1 NV;ESGVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\SbFlKSzVyPUGyPU4zOSCwTR?= M172XXNCVkeHUh?=
RPMI-7951 NF7BVXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF|MD6xOEBvVQ>? NEHZN5pUSU6JRWK=
NCI-H1648 NUDtb3dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH1TWM2OD1zM{GuPVQhdk1? NGnrXGNUSU6JRWK=
NCI-H64 NFLiV45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTF|Mj62OUBvVQ>? NVHoVo8yW0GQR1XS
HT-3 M4nJZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[2XWlEPTB;MUOzMlA1KG6P Mlr5V2FPT0WU
NCI-H1770 NW\0ZZFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXLb4FCUUN3ME2xN|MvOjFibl2= MWPTRW5ITVJ?
NB13 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\ZTWM2OD1zM{SuOVUhdk1? MmjrV2FPT0WU
NCI-H747 NXr1[YlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PuSmlEPTB;MUO1MlAzKG6P NYPIUFRrW0GQR1XS
ML-2 Mnm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vJeWlEPTB;MUO1MlE3KG6P MU\TRW5ITVJ?
CA46 Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nOdGlEPTB;MUO2Mlg5KG6P MYHTRW5ITVJ?
ES6 NHHMeZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF|Nz6xNkBvVQ>? NWrUSnd5W0GQR1XS
JiyoyeP-2003 NFvTelhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvLelNKSzVyPUGzO{45KG6P NELsO5FUSU6JRWK=
NMC-G1 MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmO3TWM2OD1zM{muNVMhdk1? NH\wd2xUSU6JRWK=
U-698-M NFXlXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHlUYpKSzVyPUGzPU42KG6P NX\DfnFQW0GQR1XS
LU-99A M1XlcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrsTWM2OD1zNE[uOVUhdk1? M2C0NHNCVkeHUh?=
NCI-H748 M4S1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF2Nz6zNUBvVQ>? MWrTRW5ITVJ?
SK-MEL-3 MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjUd4xFUUN3ME2xOFcvPjFibl2= NWLnRYlJW0GQR1XS
SNB75 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\nZ2lEPTB;MUS4MlY2KG6P NIj6PYVUSU6JRWK=
BB65-RCC NWf6cIc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;sTWM2OD1zNEmuN|Ehdk1? NXj1XJJ6W0GQR1XS
NCI-H1355 NHPrW5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXjTVZKSzVyPUG1Nk4zPCCwTR?= NUO4bplpW0GQR1XS
SCC-25 NHPuUnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y5fWlEPTB;MUWzMlc{KG6P MkjmV2FPT0WU
OAW-42 NGLIN5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn3NY1KSzVyPUG1N{45PCCwTR?= MXnTRW5ITVJ?
MONO-MAC-6 NV3XT3djT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3UTWM2OD1zNUSuN|Yhdk1? NHXkdZRUSU6JRWK=
WSU-NHL NX;ydodpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF3ND61PEBvVQ>? Ml[3V2FPT0WU
SNU-423 NHuwV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF3NT6zOEBvVQ>? MVvTRW5ITVJ?
SBC-1 NETkcm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLNTWM2OD1zNU[uOEBvVQ>? MVPTRW5ITVJ?
OVCAR-4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP1TJVKSzVyPUG1Ok44QCCwTR?= M3PH[XNCVkeHUh?=
NCI-H2347 NGLCSIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnpTWM2OD1zNUiuN|Qhdk1? M1jVbHNCVkeHUh?=
CAMA-1 NIPqdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2S3NGlEPTB;MUW5MlM{KG6P MV;TRW5ITVJ?
GDM-1 M2q2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jVWWlEPTB;MUW5Mlchdk1? MmnQV2FPT0WU
KNS-81-FD MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPaTWM2OD1zNkCuN|Ihdk1? MVfTRW5ITVJ?
no-10 NVPTUpNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH1fnVHUUN3ME2xOlAvOzhibl2= NX\he4FqW0GQR1XS
NCI-H2052 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTF4MD60O{BvVQ>? NEXmOJNUSU6JRWK=
DB MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTF4MT63NUBvVQ>? M2jh[XNCVkeHUh?=
A4-Fuk NU\1V2JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTF4Mj60PEBvVQ>? M4rncHNCVkeHUh?=
HCE-T M1KxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTpSFFKSzVyPUG2OE45PyCwTR?= MVzTRW5ITVJ?
HuP-T3 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzrWG1TUUN3ME2xOlUvPTVibl2= MUDTRW5ITVJ?
BC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\0PWlEPTB;MU[1Mlg3KG6P M1HsbXNCVkeHUh?=
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EVSA-T MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoO0TWM2OD1{LkOwNFg6KM7:TR?= NGrnbmlUSU6JRWK=
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COLO-792 MlPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTNwMEK4O{DPxE1? Ml6xV2FPT0WU
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Mewo NEPLXHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTNwNE[wPFYh|ryP M1:xe3NCVkeHUh?=
COLO-824 NVjSPXM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fZNmlEPTB;Mz61O|M4QCEQvF2= NHGyVpFUSU6JRWK=
SCC-9 NHSwVpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HFbmlEPTB;Mz65NVMxQSEQvF2= MWTTRW5ITVJ?
CP50-MEL-B MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;MTlFKSzVyPUOuPVg4ODNizszN NX7sbnR{W0GQR1XS
NCI-H345 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTRwMEGxO|Qh|ryP MXPTRW5ITVJ?
COR-L88 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPFTWM2OD12LkO5OVgh|ryP M1S1VXNCVkeHUh?=
RCM-1 NFO1Z3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDPTWM2OD12LkS5NlczKM7:TR?= NVrXbJVWW0GQR1XS
JVM-3 M{LMe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTRwNkC2NVgh|ryP NEj5ZZVUSU6JRWK=
ECC4 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\1U|F6UUN3ME20Mlc3PTRzIN88US=> MUTTRW5ITVJ?
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D-502MG M2HaR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf3TWM2OD13LkK0NlYzKM7:TR?= MVLTRW5ITVJ?
NCI-H2227 NFfSZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnmeGJKSzVyPUWuN|YzOzFizszN MXTTRW5ITVJ?
DMS-53 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXuyNmNwUUN3ME22MlE4OTB4IN88US=> NVLGXINQW0GQR1XS
LB771-HNC M3SyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O1OmlEPTB;Nj60OlgxPiEQvF2= MmK0V2FPT0WU
BB49-HNC M3y2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G0[2lEPTB;Nz60NVc6OSEQvF2= NE\ESIpUSU6JRWK=
MDA-MB-415 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jmcGlEPTB;Nz61O|MxOyEQvF2= MofWV2FPT0WU
TALL-1 NYD3UHQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTdwOU[4PEDPxE1? NFPkUHZUSU6JRWK=
HCC1395 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XFbWlEPTB;OD6xOVEzOiEQvF2= NX3lNo1rW0GQR1XS
EFE-184 MmrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO0WFhKSzVyPUiuN|czOTZizszN MnfFV2FPT0WU
EC-GI-10 NHjvcHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTHSGRKSzVyPUiuOlg3QDZizszN MX7TRW5ITVJ?
TT MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnYTWM2OD17LkC2PVY3KM7:TR?= M3\5THNCVkeHUh?=
U-2-OS M3zHS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37yeGlEPTB;OT64NVM6OyEQvF2= M4H0T3NCVkeHUh?=
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A498 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\XR2lEPTB;MUiuNlk4PiEQvF2= NFHGSFdUSU6JRWK=
LS-513 NWC5UGlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrWTWM2OD1zOD62NFk{KM7:TR?= Mo\hV2FPT0WU
K052 NGi1PYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnviTWM2OD1{MT60OFE5KM7:TR?= NIfWSFBUSU6JRWK=
SiHa NVjDfpBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTZN4JNUUN3ME2yN{4{OzdzIN88US=> MWTTRW5ITVJ?
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C32 M{TLUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV62fFhjUUN3ME2zNk45PzJizszN MmPNV2FPT0WU
SW684 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXkTWM2OD1|ND6xOVYyKM7:TR?= M4iyfHNCVkeHUh?=
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NCI-H720 M2\kfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPlTWM2OD12MT65O|I3KM7:TR?= MXfTRW5ITVJ?
P31-FUJ NVH5WIVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13Oe2lEPTB;NESuN|I5PCEQvF2= M2[w[XNCVkeHUh?=
NCI-H524 M4eyW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHyVmxKSzVyPUS4MlgzPDhizszN MkPZV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]
臨床試験 A Phase III study of Doxorubicin alone vs. Doxorubicin in combination with TH-302 in subjects with locally advanced unresectable or metastatic soft tissue sarcoma is currently ongoing.
特集

プロトコル (参考用のみ)

動物実験: [1]

動物モデル Female athymic nude mice injected s.c. with MB231 cells
製剤 Dissolved in DMSO, and diluted in saline
投薬量 3 mg/kg/day
投与方法 Delivered intratumorly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Doxorubicin (Adriamycin) SDF
分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管 3年-20℃
2年-80℃in solvent
別名 NSC 123127
溶解度 (25°C) * In vitro DMSO 100 mg/mL warming (172.41 mM)
Water 20 mg/mL (34.48 mM)
Ethanol <1 mg/mL
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 (8S,10S)-10-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

文献中の引用 (28)

Frequently Asked Questions

  • Question 1
    Why the IC50 of the compound varied over time in our measurement?

    Answer: Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

技術サポート&よくある質問(FAQ)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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