Doxorubicin (Adriamycin)

Licensed by Pfizer 製品コードS1208 別名:NSC 123127

Doxorubicin (Adriamycin)化学構造

分子量(MW):579.98

文献中の引用(31)

カスタマーフィードバック(8)

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) purchased from Selleck.

    Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) purchased from Selleck.

  • Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017.. Doxorubicin (Adriamycin) purchased from Selleck.

    (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) purchased from Selleck.

  •  

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) purchased from Selleck.

    Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) purchased from Selleck.

  • PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) purchased from Selleck.

    CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) purchased from Selleck.

製品安全説明書

Topoisomerase阻害剤の選択性比較

生物活性

製品説明 Doxorubicin (Adriamycin)は一種の抗生物質試薬ですが、腫瘍細胞の中にDNA topoisomerase IIを抑制し、DNA損傷とアポトーシスを誘導します。
靶点
Topo II [1]
(Tumor cells)
In vitro試験

Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. [2] Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and accumulation of doxorubicin in the nucleus. [3] Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. [5] Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. [6] Doxorubicin elicits a marked heat shock response, and that either inhibition or silencing of heat shock proteins enhance the Doxorubicin apoptotic effect in neuroblastoma cells. Nanomolar Doxorubicin treatment of neuroblastoma cells causes dose-dependent over-ubiquitination of a specific set of proteins in the absence of measurable inhibition of proteasome, and loss of activity of ubiquitinated enzymes such as lactate dehydrogenase and α-enolase, the protein ubiquination patterns of which is similar to those with proteasome inhibitor Bortezomib, indicating that Doxorubicin may also exert its effect by damaging proteins. [8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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SK-MEL M3;ldmN6fG:2b4jpZ{BCe3OjeR?= MlvOOFghcA>? M{XifmROW09? NXrtSot{UUN3ME2xMlUh|ryP NHfBO2kzOzV2N{i0Ny=>
MA9.3 M2nyVmN6fG:2b4jpZ{BCe3OjeR?= M3nITVExOCEQvF2= NUP1bmlVPDhiaB?= M3jv[mlEPTB;MD6wPFYh|ryP Ml;KNlM2Pzh4OUC=
A673 NVLzS5p1S3m2b4TvfIlkKEG|c3H5 MVe3NkBp M4D3bWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE3PzNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JJJme2G8dYLpck9z\XOxcoXmbY4u[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5JJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? NHjmUIszOzZyMEmyOS=>
A673 MnH5RZBweHSxc3nzJGF{e2G7 NEnieWYzPCCq Mn3ESG1UVw>? M1vtTmlv\HWldHnvckBw\iCjcH;weI9{cXNiYYPz[ZN{\WRiYYOgZ4F{eGG|ZT2zJIFkfGm4YYTpc44hf2m2aDDFR|UxKG:oIECuN|kh|ryP MXqyN|YxODl{NR?=
MDA-MB-436 Mlv3R5l1d3SxeHnjJGF{e2G7 M{nWc|czKGh? NV3UZm46UUN3ME2wMlEh|ryP MnTsNlM3ODB7MkW=
MNNG-HOS MVzDfZRwfG:6aXOgRZN{[Xl? MYO3NkBp NVzjfoJoUUN3ME2wMlU6KM7:TR?= NH71TpgzOzZyMEmyOS=>
NCI-H929 M1G3Z2N6fG:2b4jpZ{BCe3OjeR?= MX:3NkBp M2XQd2lEPTB;MD6wOlUh|ryP NVXZfGdUOjN4MEC5NlU>
SK-BR-3 MY\DfZRwfG:6aXOgRZN{[Xl? M4S3SVczKGh? MmnkTWM2OD1yLkC5JO69VQ>? NXLSUYlmOjN4MEC5NlU>
SK-ES-1 MYfDfZRwfG:6aXOgRZN{[Xl? NVv1c4FDPzJiaB?= NHjoXFdKSzVyPUCuNFQzKM7:TR?= NGf4UIUzOzZyMEmyOS=>
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SW872 M3;ZS2N6fG:2b4jpZ{BCe3OjeR?= MlPBO|IhcA>? MkLJTWM2OD1yLkG0JO69VQ>? NHrsUVUzOzZyMEmyOS=>
U266 NVLEd3FwS3m2b4TvfIlkKEG|c3H5 MkLSO|IhcA>? MmD1TWM2OD1yLk[3JO69VQ>? NIXWcI8zOzZyMEmyOS=>
JURKAT-TALL NH7oWWREgXSxdH;4bYMhSXO|YYm= M1HRRlQ5KGh? Mn6zTWM2OD1yLkCwPVYh|ryP MUCyN|Y4OzJzOB?=
B16F10 MXTDfZRwfG:6aXOgRZN{[Xl? NXKwZpZSPDhiaB?= MWXEUXNQ NU\kWnZNUUN3ME2wMlA4OiEQvF2= Mk\ENlM4Pzd6OUi=
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LS180 NV:0XYxjS3m2b4TvfIlkKEG|c3H5 NHrpR2k4OiCq M2Ll[mROW09? M2D1cGlEPTB;MD6wOEDPxE1? NHXTbXUzOzh{N{G3PS=>
COLO205 NI\rc5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTCcppwOTByIN88US=> NYPz[4hYPDhiaB?= MYrHTVUxRTBwMUSg{txO M33tTVI{QDR7MkC3
DWD M4fT[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvHZphyOTByIN88US=> NH:1S4U1QCCq MXLHTVUxRTBwMTFOwG0> NYHZ[pJQOjN6NEmyNFc>
Gurav NUPmeHlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\wUlExOCEQvF2= NVHYeVhOPDhiaB?= MULHTVUxRTBwMUeg{txO MVWyN|g1QTJyNx?=
HOP62 Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnsRW8yODBizszN NHP1Z3Q1QCCq M2TQU2dKPTB;MD6xOEDPxE1? NELqbWYzOzh2OUKwOy=>
786-0 MmfRR5l1d3SxeHnjJGF{e2G7 NWWwTXRqOTByIN88US=> MYW0PEBp NVOwWJVTT0l3ME2wMlE{KM7:TR?= MljGNlM5PzF7MEW=
ACHN MnP1R5l1d3SxeHnjJGF{e2G7 NG\uc5YyODBizszN NUnRdWJMPDhiaB?= MmrhS2k2OD1yLkC4JO69VQ>? M1XldFI{QDdzOUC1
Caki1 NUT1S3ZZS3m2b4TvfIlkKEG|c3H5 MY[xNFAh|ryP MX:0PEBp MkXSS2k2OD1yLkm1JO69VQ>? MYWyN|g4OTlyNR?=
EKVX Mnq0R5l1d3SxeHnjJGF{e2G7 NY\tPVAyOTByIN88US=> NHrpUoo1QCCq MUHHTVUxRTBwNEGg{txO NVvOdZBiOjN6N{G5NFU>
HCC2998 NHG0PY9EgXSxdH;4bYMhSXO|YYm= NVLLc|NIOTByIN88US=> Mmr5OFghcA>? NGfMUnZIUTVyPUCuNlYh|ryP NEfCbFEzOzh5MUmwOS=>
HOP92 MkjNR5l1d3SxeHnjJGF{e2G7 MlHwNVAxKM7:TR?= M4PtUlQ5KGh? MljXS2k2OD1yLkGg{txO NGnYUZUzOzh5MUmwOS=>
IGROVI MnLMR5l1d3SxeHnjJGF{e2G7 M1HNU|ExOCEQvF2= M{DFSVQ5KGh? NYD5VoZGT0l3ME2wMlE4KM7:TR?= M2TYRVI{QDdzOUC1
KM12 Mn3KR5l1d3SxeHnjJGF{e2G7 NFz0Z2IyODBizszN NUL2bpJiPDhiaB?= NWmyVHhYT0l3ME2wMlI4KM7:TR?= NGHwfZczOzh5MUmwOS=>
LOXIMVI MX;DfZRwfG:6aXOgRZN{[Xl? M3:4SFExOCEQvF2= MY[0PEBp M3nqcmdKPTB;MD6wO{DPxE1? NWjadZplOjN6N{G5NFU>
M14 MXnDfZRwfG:6aXOgRZN{[Xl? MoDmNVAxKM7:TR?= M3jjblQ5KGh? MlT3S2k2OD1yLkG4JO69VQ>? NY\pUGZUOjN6N{G5NFU>
MALME-3M M3nFNGN6fG:2b4jpZ{BCe3OjeR?= M3z3clExOCEQvF2= NF\EcVA1QCCq NUHrbphXT0l3ME2wMlEzKM7:TR?= NWq3cJdROjN6N{G5NFU>
NCI-H226 NH;I[YdEgXSxdH;4bYMhSXO|YYm= MXixNFAh|ryP MmfiOFghcA>? M4fR[2dKPTB;MD6wOUDPxE1? M3nuWVI{QDdzOUC1
NCI-H322M NHjv[VlEgXSxdH;4bYMhSXO|YYm= MljCNVAxKM7:TR?= NGHhT4o1QCCq NYW5d3k2T0l3ME2wMlU1KM7:TR?= MYKyN|g4OTlyNR?=
NCI-H522 MVTDfZRwfG:6aXOgRZN{[Xl? M4jJWFExOCEQvF2= M136[FQ5KGh? NV\0fIxmT0l3ME2wMlA{KM7:TR?= NIfWZ2czOzh5MUmwOS=>
OVCAR4 Mn7rR5l1d3SxeHnjJGF{e2G7 M{fpbVExOCEQvF2= NIjJ[FA1QCCq NVLX[|RkT0l3ME2wMlM4KM7:TR?= M3rHPVI{QDdzOUC1
OVCAR5 Mke2R5l1d3SxeHnjJGF{e2G7 NWLHTWt5OTByIN88US=> NH\YXoc1QCCq NET4UJNIUTVyPUCuOFEh|ryP NVLFOZBDOjN6N{G5NFU>
OVCAR-8 NVvpfldxS3m2b4TvfIlkKEG|c3H5 MV[xNFAh|ryP NXe0WXFWPDhiaB?= MkS1S2k2OD1yLkGg{txO MXmyN|g4OTlyNR?=
PRMI8226 NVjDbmIzS3m2b4TvfIlkKEG|c3H5 MVuxNFAh|ryP NFvCcXY1QCCq MVXHTVUxRTBwMEig{txO NFPNUJozOzh5MUmwOS=>
RXF393 NGrsU|VEgXSxdH;4bYMhSXO|YYm= NEfSVlcyODBizszN MV[0PEBp MkPCS2k2OD1yLkGg{txO NFr1VVUzOzh5MUmwOS=>
SF539 MknIR5l1d3SxeHnjJGF{e2G7 MmS4NVAxKM7:TR?= MnW1OFghcA>? NYSw[45FT0l3ME2wMlEzKM7:TR?= MVyyN|g4OTlyNR?=
SK-MEL-28 NEDJOo1EgXSxdH;4bYMhSXO|YYm= M1XydFExOCEQvF2= MXS0PEBp NIDPU4NIUTVyPUCuNlEh|ryP MV6yN|g4OTlyNR?=
SN12C MlPHR5l1d3SxeHnjJGF{e2G7 NH;0XFkyODBizszN MXu0PEBp MkjzS2k2OD1yLkC3JO69VQ>? MYSyN|g4OTlyNR?=
SNB19 NHfx[lVEgXSxdH;4bYMhSXO|YYm= MofJNVAxKM7:TR?= NWe0U4pKPDhiaB?= NYrUVGZnT0l3ME2wMlA1KM7:TR?= MmXyNlM5PzF7MEW=
SNB75 M3GwdmN6fG:2b4jpZ{BCe3OjeR?= M4jhUVExOCEQvF2= NVG4epl2PDhiaB?= NYHqNFdDT0l3ME2wMlA4KM7:TR?= M4r3TVI{QDdzOUC1
SR MnXPR5l1d3SxeHnjJGF{e2G7 NYXoUm5qOTByIN88US=> MoTpOFghcA>? M3XJemdKPTB;MD6wN{DPxE1? MlnvNlM5PzF7MEW=
TK10 M{LNcGN6fG:2b4jpZ{BCe3OjeR?= MkLnNVAxKM7:TR?= M2LpS|Q5KGh? NFvjb21IUTVyPUCuNVgh|ryP NGLIV4EzOzh5MUmwOS=>
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UACC257 NGnNU3hEgXSxdH;4bYMhSXO|YYm= NVHCSZlxOTByIN88US=> MUG0PEBp MWrHTVUxRTBwMUSg{txO MnrPNlM5PzF7MEW=
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HaCaT MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3X4XFI2KM7:Zz;tUC=> MojZOFghcA>? MoS2WGdKPTB;MD60JO69VQ>? M1XUU|I{QDd4M{O4
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H9c2 NHXtbYpHfW6ldHnvckBCe3OjeR?= MVW1JO69VQ>? MVOyOEBp M2X6V2FvfGmxeHnkZY51KGGldHn2bZR6KGG|c3Xzd4VlKGG|IHnueJJi[2WubIXsZZIhdWGub375cIRq[WymZXj5[IUhdGW4ZXy= NHr5e44zOzl5M{KxNy=>
H9c2 NWW1W5hLTnWwY4Tpc44hSXO|YYm= MWK1JO69VQ>? M323VlI1KGh? Mm\rRY51cW:6aXThcpQh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBTV1NibHX2[Yw> NIW3Um0zOzl5M{KxNy=>
H9c2 M2ftR2Z2dmO2aX;uJGF{e2G7 NUWxRpJSPSEQvF2= Mnq0NlQhcA>? MXPD[YxtfWyjcjD1dJRic2V? NEfqXYYzOzl5M{KxNy=>
MCF7 NY\kWFhzTnWwY4Tpc44hSXO|YYm= NFKyenY2KM7:TR?= M3i1dVI1KGh? M2rz[GFvfGmxeHnkZY51KGGldHn2bZR6KGG|c3Xzd4VlKGG|IHnueJJidWm2b3Poc45lemmjbDDSU3MhdGW4ZXy= NYnpR5IxOjN7N{OyNVM>
MCF7 NEDRNnJHfW6ldHnvckBCe3OjeR?= M13Tb|Uh|ryP M1XzeFI1KGh? MX\D[YxtfWyjcjD1dJRic2V? M4PRU|I{QTd|MkGz
MCF7 NH7v[ZBHfW6ldHnvckBCe3OjeR?= MlvxOUDPxE1? MX[yOEBp M{TOUmFvfGmxeHnkZY51KGGldHn2bZR6KGG|c3Xzd4VlKGG|IHnueJJi[2WubIXsZZIhdWGub375cIRq[WymZXj5[IUhdGW4ZXy= NXq5SJRzOjN7N{OyNVM>
MCF7 MYHGeY5kfGmxbjDBd5NigQ>? NH71R3c2KM7:TR?= M2e5NVI1KGh? MmLHR4VtdHWuYYKgeZB1[Wun M4m4SVI{QTd|MkGz
MDA-MB-231 NW\wPHVtTnWwY4Tpc44hSXO|YYm= NWXiV4Q1PSEQvF2= MmTHNlQhcA>? NVmzTWw2S2WubIXsZZIhfXC2YXvl MXOyN|k4OzJzMx?=
MDA-MB-231 MojrSpVv[3Srb36gRZN{[Xl? NInBZpQ2KM7:TR?= MkfuNlQhcA>? NFHD[VRCdnSrb4jp[IFvfCCjY4Tpeol1gSCjc4Pld5Nm\CCjczDpcpRz[WOnbHz1cIFzKG2jbH;ufYxlcWGuZHXofYRmKGyndnXs NUDSZXRxOjN7N{OyNVM>
MDA-MB-231 NUjCdHo6TnWwY4Tpc44hSXO|YYm= NFPUd|M2KM7:TR?= NGPQU3ozPCCq MYrBcpRqd3irZHHueEBi[3Srdnn0fUBie3Onc4Pl[EBieyCrboTyZY1qfG:laH;u[JJq[WxiUl;TJIxmfmWu NXHDc21OOjN7N{OyNVM>
KB/HeLa NHPsO2lEgXSxdH;4bYMhSXO|YYm= NYrMVoNQPDViaB?= M3vzV2VEPTB;MD6yOUDPxE1? NED2WIQzOzl6OEO1NS=>
HUVEC NUfET3BJS3m2b4TvfIlkKEG|c3H5 NEjIZXY1QCCq NImxdVJKSzVyPUCuNFgxPyEQvF2= MnLxNlQxOTJ|N{i=
HepG2 NX;SemwzTnWwY4Tpc44hSXO|YYm= MUS0NEDPxGdxbVy= NFq3epk1QCCq NX60emZZTE2VTx?= M3PqemlvcGmkaYTpc44hd2ZiVGLLJJdqfGhiSVO1NEBw\iByLkCwNlUh|ryP M{nwUVI1ODF|NEGx
MRC5 M3vqeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjTfoxsPzJiaB?= NUn0NI9LUUN3ME2wMlEh|ryP M2XTeVI1ODJzNE[y
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MDA-MB-435 NYrPSIRpS3m2b4TvfIlkKEG|c3H5 NWnGVXltOTByIN88US=> M2XCblQ5KGh? NF2wcXNKSzVyPUCuNVUh|ryP NF2wVnYzPDB{OES0Oi=>
AS49-RAW NV\DT25bS3m2b4TvfIlkKEG|c3H5 MYqxNFAh|ryP NXj3SIY3PDhiaB?= M2ThPWlEPTB;M{KuO|gh|ryP NXzHTGhLOjRyN{e1Nlg>
Caov3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X1OlczKGh? NGn5[WhKSzVyPUCuNUDPxE1? NVHCSotiOjRyOUWwPFk>
LNcaP NFPu[IpHfW6ldHnvckBCe3OjeR?= M1jEW|Mh|ryP M1vO[VI1KGh? Mn[wTY5kemWjc3Wgc4Yh[2ynYY\l[EBk[XOyYYPlMVkhdGW4ZXy= MWGyOFA6PTB6OR?=
LNcaP M1fWVGZ2dmO2aX;uJGF{e2G7 NY\lNJZ{OyEQvF2= MorkNlQhcA>? M1ezXHVxNXKnZ4XsZZRqd25ib3[gdFU{KGW6cILld5Nqd25? NVLTPVJROjRyOUWwPFk>
OVCAR8 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnflNlAh|ryP NH7HWmM4OiCq M13LW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5 NIe4NoYzPDB7NUC4PS=>
U2OS MnTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWG3NkBp NU\h[2lUUUN3ME2wMlMh|ryP M3jMd|I1ODl3MEi5
Caco2 M2nlcGN6fG:2b4jpZ{BCe3OjeR?= MmPEOFAh|ryP MoHlNlQhcA>? NIjwNGVEgXSxdH;4bYNqfHl? NHmyPFIzPDB7OUm5OC=>
MDA-MB-468 NE\RenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4L6VFExKM7:TR?= NEL6cYI4OiCq M1GyUGdKPTB;MD6wPFUh|ryP MX[yOFE3Ozd{OR?=
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NCI-H719 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvSNnJKSzVyPUO5MlY2KG6P NV7EfXJvW0GQR1XS
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NCI-H358 NF3QS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;5TWM2OD12MT6wPEBvVQ>? MV3TRW5ITVJ?
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NCI-H292 MlTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TPOmlEPTB;NEOuO|Yhdk1? MVTTRW5ITVJ?
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NCI-H2087 NV3qbWFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe2O3RHUUN3ME20PU41OiCwTR?= Mn3VV2FPT0WU
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NCI-H526 NYjFPGNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:z[YFKSzVyPUS5Mlk3KG6P MnfyV2FPT0WU
Ca9-22 NH3DTo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTVyLkC3JI5O NWjsV2NMW0GQR1XS
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BE-13 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PnV2lEPTB;NUGuNFIhdk1? MlzLV2FPT0WU
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CAPAN-1 M2jFOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jXU2lEPTB;NUGuO|Yhdk1? NGLYSXpUSU6JRWK=
NCI-H2009 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\hT2lEPTB;NUGuO|Yhdk1? MVrTRW5ITVJ?
NCI-H522 NYfYfo5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnjdZhQUUN3ME21NU46OyCwTR?= NHjYZXJUSU6JRWK=
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BCPAP NEXv[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPPUXlpUUN3ME21Nk42KG6P NVHIPI81W0GQR1XS
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RPMI-8402 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mom5TWM2OD13Mz64OkBvVQ>? M4rFO3NCVkeHUh?=
Calu-3 NYLNWZhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jIR2lEPTB;NUWuPVghdk1? MofHV2FPT0WU
COR-L279 MnvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTV4Lkm1JI5O NYHzPGYxW0GQR1XS
T84 M3LYbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fHVWlEPTB;NUeuNFYhdk1? M4fjPHNCVkeHUh?=
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KYSE-180 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrrTWM2OD13OT63OUBvVQ>? NWLW[ldTW0GQR1XS
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OVCAR-8 NVf3R4pvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTZzLkmyJI5O NYP0fFhjW0GQR1XS
HL-60 Ml;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jEXWlEPTB;NkKuOVYhdk1? MoG0V2FPT0WU
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IA-LM Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO3TWM2OD14Mz61OEBvVQ>? NIGzNohUSU6JRWK=
HCC2157 NUTReINxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFqwOZJKSzVyPU[zMlk2KG6P M3KyU3NCVkeHUh?=
CTB-1 M{W2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGxTWM2OD14NECxPUBvVQ>? M1\zfXNCVkeHUh?=
NCI-H1437 M{DOfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTZ2Lk[0JI5O NILCW4FUSU6JRWK=
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OVCAR-5 NFj3[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;GW|RKSzVyPUGxOk45OSCwTR?= M{S5O3NCVkeHUh?=
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NCI-H28 NV\zW|lRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfyTWM2OD1zLke0NFc5KM7:TR?= NXKzSlVlW0GQR1XS
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LN-405 M3LHe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjoWI9KSzVyPUGuPFAyPDNizszN M33tRXNCVkeHUh?=
RT4 NYXBRYppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe5T4FWUUN3ME2xMlg1PDF5IN88US=> NIj2N4lUSU6JRWK=
NCI-H889 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTFwOUO4PFYh|ryP NYqwVWNpW0GQR1XS
SW1463 NVXBc2JVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTFwOUW3NFEh|ryP MoTHV2FPT0WU
SCLC-21H MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\kTWM2OD1{LkCwOlI1KM7:TR?= MmTIV2FPT0WU
CP66-MEL NEmxPINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJwMEG3Olch|ryP M1jNRXNCVkeHUh?=
Hs-578-T MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXKTGRKSzVyPUKuNFE4QDJizszN NHLrenpUSU6JRWK=
HCC70 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr2dXJKSzVyPUKuNFU1PjNizszN NWSyRXNOW0GQR1XS
SW1088 M{Cwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTTd25KSzVyPUKuNFY6OzFizszN MVrTRW5ITVJ?
NB6 M1;DRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT2TWM2OD1{LkG4OUDPxE1? NGXTVnBUSU6JRWK=
KU-19-19 NWLZPZlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG2OGdKSzVyPUKuNlY6OTdizszN MWnTRW5ITVJ?
A704 M3m5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XHV2lEPTB;Mj6yPVE{PSEQvF2= NYnBe4JsW0GQR1XS
EVSA-T MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHSUm9KSzVyPUKuN|AxQDlizszN MnfvV2FPT0WU
HCT-15 NXTWcGRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkW3TWM2OD1{LkO1OFY3KM7:TR?= Mo\IV2FPT0WU
HuO-3N1 NIq2d4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml20TWM2OD1{LkO2OVg{KM7:TR?= M{ezWXNCVkeHUh?=
GMS-10 NIezfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{WwUmlEPTB;Mj6zPVc{QCEQvF2= M1fxTHNCVkeHUh?=
TGBC24TKB MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoWyTWM2OD1{LkSxOFI6KM7:TR?= MYTTRW5ITVJ?
C2BBe1 M3y1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTJwNUGzNlgh|ryP M1nYfnNCVkeHUh?=
SK-N-DZ MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4D1OWlEPTB;Mj61OlU6OiEQvF2= NVTUXld7W0GQR1XS
SK-N-AS NY\pOWdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJwN{OwNVUh|ryP NWTj[ZZDW0GQR1XS
T98G MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHIOVFKUUN3ME2yMlgxPDBzIN88US=> NELCe2FUSU6JRWK=
DMS-79 MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17WNGlEPTB;Mj65NFk5QCEQvF2= NXyzTm9UW0GQR1XS
SNU-475 MoDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfNe5ZKSzVyPUKuPVI2PzJizszN NHr6eXBUSU6JRWK=
COLO-792 NF65VHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTNwMEK4O{DPxE1? MVvTRW5ITVJ?
YAPC M4TNb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPvV49KSzVyPUOuN|I5OzJizszN NGLPbnBUSU6JRWK=
UACC-812 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\UO4tPUUN3ME2zMlM{PzN6IN88US=> NW\vVm9KW0GQR1XS
Mewo MorLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTNwNE[wPFYh|ryP MofxV2FPT0WU
COLO-824 NXPIVIRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjQS41KSzVyPUOuOVc{PzhizszN NGW5RXhUSU6JRWK=
SCC-9 MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33QfmlEPTB;Mz65NVMxQSEQvF2= NIiwPI9USU6JRWK=
CP50-MEL-B MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoC5TWM2OD1|Lkm4O|A{KM7:TR?= MknSV2FPT0WU
NCI-H345 M{nLUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvyTWM2OD12LkCxNVc1KM7:TR?= MXnTRW5ITVJ?
COR-L88 M1\tbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu4TWM2OD12LkO5OVgh|ryP M{fYWXNCVkeHUh?=
RCM-1 NEfsSpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTRwNEmyO|Ih|ryP NXnxc2dsW0GQR1XS
JVM-3 NXH0U49mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:4UnhKSzVyPUSuOlA3OThizszN M4TncHNCVkeHUh?=
ECC4 NYe4TpdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrVTWM2OD12Lke2OVQyKM7:TR?= NVjCZ2NbW0GQR1XS
MDA-MB-453 NIT3V2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTQdGRPUUN3ME20Mlg2OTN2IN88US=> MVTTRW5ITVJ?
SK-N-FI MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzHTGhxUUN3ME21MlIzQDd5IN88US=> MXXTRW5ITVJ?
D-502MG NU\2[lFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nTdmlEPTB;NT6yOFI3OiEQvF2= NIjacGFUSU6JRWK=
NCI-H2227 M2rZTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUS0OlNMUUN3ME21MlM3OjNzIN88US=> NEPMcXBUSU6JRWK=
DMS-53 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTZwMUexNFYh|ryP NFzxcJlUSU6JRWK=
LB771-HNC MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTZwNE[4NFYh|ryP MYHTRW5ITVJ?
BB49-HNC NHK1b|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTdwNEG3PVEh|ryP M2DxbXNCVkeHUh?=
MDA-MB-415 NVjuXY1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTdwNUezNFMh|ryP M3LOO3NCVkeHUh?=
TALL-1 M2HEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXjTWM2OD15Lkm2PFgh|ryP Ml\kV2FPT0WU
HCC1395 M1P0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO1SYJKSzVyPUiuNVUyOjJizszN M2HiZXNCVkeHUh?=
EFE-184 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRThwM{eyNVYh|ryP Mlv1V2FPT0WU
EC-GI-10 NUnW[5p5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnGTXp5UUN3ME24MlY5Pjh4IN88US=> Mmj3V2FPT0WU
TT Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\JTWM2OD17LkC2PVY3KM7:TR?= MUTTRW5ITVJ?
U-2-OS NEDBcmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjJUG1nUUN3ME25MlgyOzl|IN88US=> NXHqbItUW0GQR1XS
SHP-77 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13HUWlEPTB;OT65NFI6KM7:TR?= NX;QWXlPW0GQR1XS
HCC1143 M3ewb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3KxOWlEPTB;MUCuOFc6PyEQvF2= M4i1WHNCVkeHUh?=
A498 NWPSfI9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHPbXRWUUN3ME2xPE4zQTd4IN88US=> MkDrV2FPT0WU
LS-513 M1zBPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;yVIhvUUN3ME2xPE43ODl|IN88US=> NInt[pBUSU6JRWK=
K052 NUfRO41HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle3TWM2OD1{MT60OFE5KM7:TR?= NHju[|FUSU6JRWK=
SiHa MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nqRWlEPTB;MkOuN|M4OSEQvF2= Ml:wV2FPT0WU
RCC10RGB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rGO2lEPTB;M{CuNFYyOSEQvF2= MV\TRW5ITVJ?
NCI-SNU-16 NU\neVRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHWbJo4UUN3ME2zNU4yQDN4IN88US=> M17ZPXNCVkeHUh?=
SNU-C1 NYDwNYlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\zTWM2OD1|Mj60NVc2KM7:TR?= NWTQN4pmW0GQR1XS
C32 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTN{Lki3NkDPxE1? M1voWHNCVkeHUh?=
SW684 M4rDXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe0VXhKSzVyPUO0MlE2PjFizszN M1rxdHNCVkeHUh?=
SK-MEL-28 M1jnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rFbWlEPTB;M{WuOVM4PyEQvF2= MlXMV2FPT0WU
SK-MEL-1 MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jrc2lEPTB;M{[uO|U1PyEQvF2= NEfEc|BUSU6JRWK=
NCI-H720 NGfQc3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXNWph3UUN3ME20NU46PzJ4IN88US=> NUHUN3YzW0GQR1XS
P31-FUJ NE\RWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\KW5lRUUN3ME20OE4{Ojh2IN88US=> NELMZVNUSU6JRWK=
NCI-H524 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXQRW5TUUN3ME20PE45OjR6IN88US=> NU\Se3g{W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 In vivo, Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. [1] Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas. [2]

プロトコル(参考用のみ)

動物実験:[1]
+ 展開
  • 動物モデル: Female athymic nude mice injected s.c. with MB231 cells
  • 製剤: Dissolved in DMSO, and diluted in saline
  • 投薬量: 3 mg/kg/day
  • 投与方法: Delivered intratumorly
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 100 mg/mL (172.41 mM) warming
Water 20 mg/mL (34.48 mM)
Ethanol <1 mg/mL
体内

* <1 mg/mlは製品が微弱に溶解する或いは溶解しないことを示します。
* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 579.98
化学式

C27H29NO11.HCl

CAS No. 25316-40-9
保管
in solvent
別名 NSC 123127

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03036904 Not yet recruiting Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma Weill Medical College of Cornell University|Genentech, Inc.|Massachusetts General Hospital|M.D. Anderson Cancer Center February 6, 2017 Phase 1
NCT02659930 Recruiting Kaposi Sarcoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 4, 2016 Phase 1
NCT03042819 Not yet recruiting Soft Tissue Sarcoma University Health Network, Toronto|Karyopharm Therapeutics, Inc March 27, 2017 Phase 1
NCT03033914 Recruiting Hodgkin Lymphoma Memorial Sloan Kettering Cancer Center|Bristol-Myers Squibb|M.D. Anderson Cancer Center|City of Hope Medical Center January 25, 2017 Phase 1
NCT02957968 Recruiting Locally Advanced Breast Cancer|Invasive Adenocarcinoma of the Breast|Breast Cancer Stage II|Breast Cancer Stage III|Breast Cancer Stage IV Virginia Commonwealth University|Merck Sharp & Dohme Corp.|National Cancer Institute (NCI) January 24, 2017 Phase 2
NCT02377752 Active, not recruiting Neoplasm Eli Lilly and Company March 23, 2015 Phase 1

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Why the IC50 of the compound varied over time in our measurement?

  • 回答:

    Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.

Topoisomerase信号経路図

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Tags: Doxorubicin (Adriamycin)を買う | Doxorubicin (Adriamycin) ic50 | Doxorubicin (Adriamycin)供給者 | Doxorubicin (Adriamycin)を購入する | Doxorubicin (Adriamycin)費用 | Doxorubicin (Adriamycin)生産者 | オーダーDoxorubicin (Adriamycin) | Doxorubicin (Adriamycin)化学構造 | Doxorubicin (Adriamycin)分子量 | Doxorubicin (Adriamycin)代理店
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID