Ponatinib (AP24534)

Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。

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Ponatinib (AP24534) 化学構造
分子量: 532.56

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製品説明

  • Compare Bcr-Abl Inhibitors
    Bcr-Abl製品生物活性の比較
  • 研究分野
  • Ponatinib (AP24534)のメカニズム

製品の説明

生物活性

製品説明 Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。
ターゲット Abl PDGFRα VEGFR2 FGFR1 Src
IC50 0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM [1]
In vitro試験 AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS0No9KSzVyPUCuNFAxODByMEO1PUDPxE1? NGDxbpZUSU6JRWK=
MV-4-11 NH3MZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXYWHN3UUN3ME2wMlAxODB7NU[g{txO NUPiNndPW0GQR1XS
MEG-01 M2q5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETKd|lKSzVyPUCuNFAxOTJ6IN88US=> MofYV2FPT0WU
LAMA-84 M3LiWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnLN3JKSzVyPUCuNFAxOTZ3IN88US=> NYqwbYFvW0GQR1XS
CGTH-W-1 NYHZVm1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrGTWM2OD1yLkCwNVY6KM7:TR?= NITlbZBUSU6JRWK=
KASUMI-1 NXTENWJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnrWZRKSzVyPUCuNFAzOTdizszN MYjTRW5ITVJ?
BE-13 NGfUNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jZRWlEPTB;MD6wNFI2QSEQvF2= NHjubGtUSU6JRWK=
CTV-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW4flFxUUN3ME2wMlAxPTJzIN88US=> Mn:xV2FPT0WU
NKM-1 M{X6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfnUI5ZUUN3ME2wMlAxPjV3IN88US=> MljKV2FPT0WU
MONO-MAC-6 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofNTWM2OD1yLkCwPFM4KM7:TR?= MlHOV2FPT0WU
A204 NEX2d25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEGyNVgh|ryP NGLzTnBUSU6JRWK=
GDM-1 NIXVellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEG4N|Mh|ryP MoP2V2FPT0WU
AN3-CA NYL5bYtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\YRmE3UUN3ME2wMlAyQDd|IN88US=> NXe3UZNrW0GQR1XS
BL-70 NXrjV3pmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDETWM2OD1yLkCyNVk6KM7:TR?= MXjTRW5ITVJ?
Daudi MoLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEGyZXlKSzVyPUCuNFI2OzdizszN NIrBR3lUSU6JRWK=
KU812 Ml\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEK4OFgh|ryP M1vZN3NCVkeHUh?=
KG-1 NYDXNnlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\MOXNKSzVyPUCuNFMzQTRizszN MV;TRW5ITVJ?
DOHH-2 MnTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK2TWM2OD1yLkC0PFA{KM7:TR?= MnqzV2FPT0WU
HuO9 M3fKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLWNYh[UUN3ME2wMlA2PDR6IN88US=> MkX1V2FPT0WU
EB2 NWC2bZJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXnTWM2OD1yLkC1OVc3KM7:TR?= MnLaV2FPT0WU
G-402 NEL6XZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwME[zOFEh|ryP M2TOZ3NCVkeHUh?=
SU-DHL-1 NXL1cpNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\SNWlEPTB;MD6wOlM4QSEQvF2= Mlf5V2FPT0WU
NCI-H719 NYLaWGxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjVc|RMUUN3ME2wMlA4QDh6IN88US=> M3y2SnNCVkeHUh?=
MLMA NHj3PGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrpTWM2OD1yLkC5NFYh|ryP Mof4V2FPT0WU
KM12 NFLnO5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vmRWlEPTB;MD6wPVc{PyEQvF2= M4PXbHNCVkeHUh?=
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MFE-296 NUiw[oJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMUG4N|kh|ryP M{LoVXNCVkeHUh?=
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GB-1 NGL4UodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDrZ|VKSzVyPUCuNVI2OTJizszN MXTTRW5ITVJ?
SIG-M5 M3[wT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjQUW5HUUN3ME2wMlE{OzdizszN NH3peXFUSU6JRWK=
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NCI-H716 M4DNVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL0WHJRUUN3ME2wMlE3OjZ4IN88US=> NV;NO2pFW0GQR1XS
MPP-89 NE\1eGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TwR2lEPTB;MD6xOlk{OyEQvF2= M1rleHNCVkeHUh?=
SF126 M4\Fe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3uTWM2OD1yLkG3NFY{KM7:TR?= M1r0UHNCVkeHUh?=
CTB-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;RV2lEPTB;MD6xO|MyPiEQvF2= M4qxSXNCVkeHUh?=
CA46 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\tRWFzUUN3ME2wMlE4PDh7IN88US=> NUjsSGc3W0GQR1XS
NCI-H520 NUnGZ5BST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7yTWM2OD1yLkG3O|MzKM7:TR?= M3LSXXNCVkeHUh?=
CAL-85-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMUe5Nlch|ryP NYTMVIxoW0GQR1XS
NCI-H2342 NEnJT|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMUi1O|ch|ryP NH;2enFUSU6JRWK=
697 NXzmUnhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMUi4O|Eh|ryP MkLKV2FPT0WU
NY MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TDWGlEPTB;MD6xPVI5PyEQvF2= NHz4XYJUSU6JRWK=
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NCI-H1703 M1e0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljaTWM2OD1yLkG5OlE2KM7:TR?= MULTRW5ITVJ?
NCI-H2087 M1vVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnXbpFKSzVyPUCuNlA1OzlizszN M3TYOXNCVkeHUh?=
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HCT-116 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DGNmlEPTB;MD6yNVA3QSEQvF2= MnPHV2FPT0WU
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CCF-STTG1 NImzTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7KZWs2UUN3ME2wMlIzPDd3IN88US=> MluyV2FPT0WU
D-392MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TobmlEPTB;MD6yN|E4PyEQvF2= NH7YZ4lUSU6JRWK=
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MES-SA M{jkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXuUpZ2UUN3ME2wMlI1OTh5IN88US=> NG\Se|RUSU6JRWK=
LC-2-ad NWjYc5RvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYS1SGVNUUN3ME2wMlI1OjZ3IN88US=> NY\oV3NEW0GQR1XS
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NALM-6 M4PTW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfBTWM2OD1yLkK1OVQ{KM7:TR?= NFXBXWNUSU6JRWK=
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786-0 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMk[yNlgh|ryP MUfTRW5ITVJ?
IST-MES1 NEP1ZoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17VTWlEPTB;MD6yOlgzQSEQvF2= MU\TRW5ITVJ?
KYSE-180 NYDUcFlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4WyfWlEPTB;MD6yOlg6OSEQvF2= NIq5S3lUSU6JRWK=
YT M13SeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7TfIdxUUN3ME2wMlI3QTd2IN88US=> MnTaV2FPT0WU
A427 M3n2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXNU2lNUUN3ME2wMlI4OjZ2IN88US=> NYLnSJd2W0GQR1XS
KYSE-450 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f2SGlEPTB;MD6yO|MzQSEQvF2= NHfSZldUSU6JRWK=
HuH-7 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMke3OlMh|ryP NIDqenJUSU6JRWK=
CAS-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMkizNFMh|ryP M4\NWXNCVkeHUh?=
KURAMOCHI NHXH[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrpTWM2OD1yLkK4OFE6KM7:TR?= M4S4OHNCVkeHUh?=
ACHN NULqO2hZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfSTWM2OD1yLkK5N|I{KM7:TR?= NV34PZptW0GQR1XS
HGC-27 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn3SoMzUUN3ME2wMlI6OzV|IN88US=> MWfTRW5ITVJ?
A172 NInHfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnsTWM2OD1yLkK5OVc4KM7:TR?= M3PheXNCVkeHUh?=
SNU-449 MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\hUWlEPTB;MD6yPVk3PCEQvF2= MonoV2FPT0WU
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EFO-21 M1\mNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwM{C0NVEh|ryP M3O2U3NCVkeHUh?=
NCI-H2030 MkLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLTfGhKSzVyPUCuN|EyPjRizszN M3KxVnNCVkeHUh?=
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MFE-280 MoDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33FOmlEPTB;MD6zNVQ2OyEQvF2= NVzQSpJxW0GQR1XS
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NCI-H2052 MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwM{G0PFQh|ryP M3L4enNCVkeHUh?=
SK-HEP-1 NUXxNINQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHKSpVKSzVyPUCuN|M{PjhizszN NF;R[2hUSU6JRWK=
QIMR-WIL NVXCXINZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzMWHlKSzVyPUCuN|M1OjRizszN NVvscXZlW0GQR1XS
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ACN NHfwZXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33HbGlEPTB;MD6zOFg4OyEQvF2= MoXxV2FPT0WU
BxPC-3 NW\Jb4VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7sSZZJUUN3ME2wMlM1QTh7IN88US=> M2CxW3NCVkeHUh?=
BCPAP NWTjN3QyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LwN2lEPTB;MD6zOlAxOSEQvF2= MlzVV2FPT0WU
HOP-62 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PFe2lEPTB;MD6zOlExPiEQvF2= M{TwWHNCVkeHUh?=
SW1710 Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T2eWlEPTB;MD6zOlQ2PSEQvF2= M1\QOHNCVkeHUh?=
OPM-2 NV3nWpFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3scJJKSzVyPUCuN|Y1PzNizszN MUTTRW5ITVJ?
DBTRG-05MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnET|lUUUN3ME2wMlM5ODV2IN88US=> M2O1VXNCVkeHUh?=
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8305C MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwM{m3PVMh|ryP MXzTRW5ITVJ?
OVCAR-4 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPuTWM2OD1yLkSxOVg3KM7:TR?= MW\TRW5ITVJ?
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NCI-H747 M1fHNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljrTWM2OD1yLkSyNVM4KM7:TR?= MV7TRW5ITVJ?
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ECC12 NWTW[FViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r2Z2lEPTB;MD61OlU2QCEQvF2= NIfXcYRUSU6JRWK=
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LCLC-103H M325bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXoTWM2OD1yLkW4N|Q1KM7:TR?= NH;oO4lUSU6JRWK=
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NCCIT MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XTWGlEPTB;MD62NVcyPSEQvF2= NX7qco1wW0GQR1XS
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BL-41 Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNkOzOVIh|ryP MmnvV2FPT0WU
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EW-13 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwNk[3O|kh|ryP NHHJV4hUSU6JRWK=
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JiyoyeP-2003 M{\GdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TRXmlEPTB;MD62PVc{QCEQvF2= NI\Ed3BUSU6JRWK=
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U-698-M NUHZO2pqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXriTmxwUUN3ME2wMlcyODZ|IN88US=> M3jqcnNCVkeHUh?=
HC-1 NHXOdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\W[WlEPTB;MD63NlQxPSEQvF2= MVPTRW5ITVJ?
8505C MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwN{K3OFEh|ryP NVOwbmliW0GQR1XS
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LB1047-RCC NVfVZVJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\yWY5KSzVyPUCuO|M2OzhizszN NGHpPXhUSU6JRWK=
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CAL-12T MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwN{O4O|ch|ryP Ml7RV2FPT0WU
NCI-SNU-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\ROY9KSzVyPUCuO|czPzhizszN MYXTRW5ITVJ?
HTC-C3 M2HMRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwN{e0OVEh|ryP NFX0XJdUSU6JRWK=
HPAF-II MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfzTWM2OD1yLke3OVAyKM7:TR?= NFH2fnhUSU6JRWK=
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EFO-27 MoHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwN{i3N|Mh|ryP MkXDV2FPT0WU
MEL-HO Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T0bGlEPTB;MD63PVQ1QSEQvF2= NXO0ZoxSW0GQR1XS
KYSE-270 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESzbnNKSzVyPUCuPFA2OjlizszN MWjTRW5ITVJ?
NCI-H1755 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i5[GlEPTB;MD64NFcyPCEQvF2= NIX1fmZUSU6JRWK=
MFM-223 NVK5VGh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHPTWM2OD1yLkixOFA4KM7:TR?= NGHQXYtUSU6JRWK=
G-361 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PtNmlEPTB;MD64NVg6PyEQvF2= NVzWfI1VW0GQR1XS
ETK-1 MnTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnqTWM2OD1yLkiyOFQyKM7:TR?= NXvqZm5rW0GQR1XS
LU-99A MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHaS3N2UUN3ME2wMlg1PzBzIN88US=> MlPIV2FPT0WU
IST-MEL1 NITYTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jROGlEPTB;MD64OVc{OiEQvF2= M1PpRXNCVkeHUh?=
L-540 MmKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XjemlEPTB;MD64OVgxOSEQvF2= MUnTRW5ITVJ?
U-2-OS NXTZOGdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLKU|lzUUN3ME2wMlg2QDR4IN88US=> M2nRdnNCVkeHUh?=
HT-1376 Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwOE[wOVEh|ryP NITy[5hUSU6JRWK=
COLO-680N NInkb|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwOEe5N|Mh|ryP NF3McIdUSU6JRWK=
NCI-H1581 NIHmbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XadWlEPTB;MD64PVI6PyEQvF2= MXLTRW5ITVJ?
HuCCT1 NFvZVINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f3NWlEPTB;MD64PVU1QCEQvF2= M{DwXnNCVkeHUh?=
BB30-HNC NYrIWId5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD1fW85UUN3ME2wMlkzPDZ7IN88US=> NGXEcG9USU6JRWK=
NCI-H2347 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXj[ZJZUUN3ME2wMlk{Ojl{IN88US=> MW\TRW5ITVJ?
G-401 NIrrenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO5bnJzUUN3ME2wMlk{Pjl3IN88US=> NVzvZ4dGW0GQR1XS
NCI-H358 NGe4TW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[yZ2lEPTB;MD65OVAyPCEQvF2= NVzrWYlIW0GQR1XS
HCC1395 NEfIcJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\mSGlEPTB;MD65OVQ3OSEQvF2= MV3TRW5ITVJ?
J82 M4PGXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XTUWlEPTB;MD65OVU1OyEQvF2= NHH4S4JUSU6JRWK=
KE-37 M1nzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjybpBpUUN3ME2wMlk3Ozh5IN88US=> MWnTRW5ITVJ?
NOMO-1 M2DNbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrKTWM2OD1yLkm2OVY1KM7:TR?= NFHmXWZUSU6JRWK=
ML-2 NVTkNoVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\5S5JXUUN3ME2wMlk6PzVizszN M3;ne3NCVkeHUh?=
SW872 M1myd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwOUm3O|Uh|ryP MmnkV2FPT0WU
KYSE-520 NXO1bZZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFO4e2JKSzVyPUGuNFA1QTRizszN NYO3cmFEW0GQR1XS
HL-60 NHvwPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwMEC5O{DPxE1? MV7TRW5ITVJ?
HDLM-2 NVT0NnNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPz[2JtUUN3ME2xMlAyOjV{IN88US=> NH\2UWRUSU6JRWK=
MIA-PaCa-2 NVfY[mw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS1TWM2OD1zLkCxN|c2KM7:TR?= NUe2c|ZTW0GQR1XS
TCCSUP NFHxWWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;ESI1LUUN3ME2xMlAyPzN{IN88US=> MUjTRW5ITVJ?
SH-4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[2fGlMUUN3ME2xMlAzOjR2IN88US=> MmPBV2FPT0WU
MG-63 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzPOZBKSzVyPUGuNFI3OTZizszN MXPTRW5ITVJ?
NB6 MmmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7TR2tTUUN3ME2xMlA{OTB7IN88US=> NIPZZ|hUSU6JRWK=
CAL-54 NXvxTmt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\a[mlEPTB;MT6wN|k2QSEQvF2= NYDwZ5NkW0GQR1XS
DU-145 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnKzTWM2OD1zLkC4NFc{KM7:TR?= M1XPSHNCVkeHUh?=
HCE-4 M4PEemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILpfZBKSzVyPUGuNFkzQDZizszN NYC2fHM5W0GQR1XS
U-266 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTFwMEm2N|Mh|ryP NIHHNoFUSU6JRWK=
HT-1197 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTFwMUG0N|gh|ryP MX3TRW5ITVJ?
EW-1 NIXBV2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrrc41KUUN3ME2xMlE1OTJ6IN88US=> NY\1U4pDW0GQR1XS
MHH-NB-11 MlLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTFwMUWzOlgh|ryP MkTFV2FPT0WU
NCI-H2405 M1u4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnzTWM2OD1zLkG2NVYh|ryP NWfvdFl2W0GQR1XS
COLO-668 NHXsfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzCTWM2OD1zLkG2OFkh|ryP NVXB[pVKW0GQR1XS
IMR-5 MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfYTWM2OD1zLkG2PVM3KM7:TR?= NG\RUIhUSU6JRWK=
ARH-77 NGHjXXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HwS2lEPTB;MT6yNlkzPCEQvF2= MU\TRW5ITVJ?
BHT-101 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXz[ZVEUUN3ME2xMlI{PDlizszN MkLTV2FPT0WU
SCC-25 MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon2TWM2OD1zLkKzOVM3KM7:TR?= Ml\WV2FPT0WU
NTERA-S-cl-D1 M2LETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULV[4NkUUN3ME2xMlI1OzR4IN88US=> MVnTRW5ITVJ?
MKN28 Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvYeWhWUUN3ME2xMlI2PjN4IN88US=> NVXodI9oW0GQR1XS
KS-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjlUY1KSzVyPUGuNlgzPjlizszN MUjTRW5ITVJ?
NCI-H1734 NYnVUndET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFwMki5NVMh|ryP Mo[4V2FPT0WU
ES7 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfnTWM2OD1zLkK5OVQzKM7:TR?= NWL1TJlUW0GQR1XS
NCI-H838 NXLoTG16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTFwM{C2NVUh|ryP M4PJd3NCVkeHUh?=
HEC-1 M2HDeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTFwM{O3OVUh|ryP MlnVV2FPT0WU
ME-180 M3rrS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTWSlJKSzVyPUGuN|c6QTNizszN M3jFd3NCVkeHUh?=
MMAC-SF M1XzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFwM{m1PVUh|ryP NV3jcY1UW0GQR1XS
IA-LM MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XzfWlEPTB;MT60NFkyPCEQvF2= MkiwV2FPT0WU
MN-60 M1[2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTFwNEOxNVQh|ryP MmfnV2FPT0WU
SIMA MlLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MluwTWM2OD1zLkS4Olg4KM7:TR?= NX7lUJpDW0GQR1XS
NCI-H1770 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHEOGdKSzVyPUGuOVIxPTRizszN NUPuXpQxW0GQR1XS
ONS-76 NV\wcY9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjCV5RKSzVyPUGuOVI{OTFizszN MknVV2FPT0WU
LB771-HNC NVPvWZp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLqTWM2OD1zLkWzPVA3KM7:TR?= NY\5TIc6W0GQR1XS
SW48 MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC2N5JQUUN3ME2xMlU1OjR|IN88US=> M2jzcnNCVkeHUh?=
KYSE-140 Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HmU2lEPTB;MT61OVc1OSEQvF2= MY\TRW5ITVJ?
SW626 MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVqxNll3UUN3ME2xMlU5OTZizszN MlzIV2FPT0WU
MC-CAR M3vCTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7PUJNKSzVyPUGuOVg3PjNizszN NUfNUFltW0GQR1XS
D-336MG NWTYeYl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;JWYdKSzVyPUGuOlI6PCEQvF2= M4GybHNCVkeHUh?=
SK-MEL-3 NWjkW41oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXew[XFrUUN3ME2xMlY{QTB{IN88US=> NIfnRVNUSU6JRWK=
MHH-PREB-1 M1faU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXIbZV7UUN3ME2xMlY1PDd|IN88US=> NXfScVJzW0GQR1XS
Calu-1 NX7t[4xzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13jcGlEPTB;MT62OVM5PiEQvF2= NFjTZ2tUSU6JRWK=
HCC1806 NFPpcJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknsTWM2OD1zLk[2OlEyKM7:TR?= M1rHO3NCVkeHUh?=
A101D Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2CzXGlEPTB;MT62Olc5OSEQvF2= NUXwbI9vW0GQR1XS
A704 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTFwNkizNVEh|ryP MkWyV2FPT0WU
LB831-BLC NGnNN2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi0TWM2OD1zLk[5PFU1KM7:TR?= MVXTRW5ITVJ?
RL95-2 M4i4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLJdYt6UUN3ME2xMlcyPDZ|IN88US=> M1\QVnNCVkeHUh?=
RPMI-2650 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFwN{K3NVkh|ryP NWDiTlB2W0GQR1XS
NH-12 MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFW2TI5KSzVyPUGuO|M1OjdizszN MUXTRW5ITVJ?
AGS MmLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O5fWlEPTB;MT63OlM2QCEQvF2= MnnxV2FPT0WU
NEC8 NEXleFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjjXlVKSzVyPUGuO|g6QTVizszN MYXTRW5ITVJ?
NCI-H2009 Mm\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXpTWM2OD1zLke5O|IyKM7:TR?= NX7OeVRzW0GQR1XS
A498 NUW5cJlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3kTWM2OD1zLkixNlgzKM7:TR?= NYDlVHAzW0GQR1XS
NCI-H810 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:wWGZzUUN3ME2xMlgyPjB4IN88US=> Mm[wV2FPT0WU
SK-NEP-1 Mn6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LSOmlEPTB;MT64N|c3PyEQvF2= NV[wcY5kW0GQR1XS
D-542MG MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2r6SWlEPTB;MT64OVg2OSEQvF2= M3HhPHNCVkeHUh?=
KNS-42 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTFwOE[yOlYh|ryP MY\TRW5ITVJ?
NCI-H2452 MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjrUphwUUN3ME2xMlg6ODd2IN88US=> MV\TRW5ITVJ?
SK-MEL-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFwOUCyO|Eh|ryP MoriV2FPT0WU
OVCAR-5 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTFwOUC2O|Uh|ryP NXradYtVW0GQR1XS
SNG-M MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrLWYRKUUN3ME2xMlk2QDV6IN88US=> MnzoV2FPT0WU
A673 NGfONXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX2O5FKSzVyPUGuPVc2OTZizszN NEOyNGRUSU6JRWK=
L-428 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDFTWM2OD1zLkm5NVc6KM7:TR?= MXLTRW5ITVJ?
KM-H2 M4nuN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuyTWM2OD1{LkCxNFkh|ryP MmPIV2FPT0WU
MC-IXC Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHNV2dSUUN3ME2yMlAzOjd|IN88US=> MYjTRW5ITVJ?
COLO-678 NHPyU3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzCclRtUUN3ME2yMlA1OjB5IN88US=> MWjTRW5ITVJ?
MEL-JUSO MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HTfmlEPTB;Mj6wO|g2OSEQvF2= M4fiWnNCVkeHUh?=
HCC38 M4SyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPOfppKSzVyPUKuNFg1OzNizszN NH7VZ45USU6JRWK=
UACC-62 M4rX[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X5O2lEPTB;Mj6wPFg2PSEQvF2= MmHuV2FPT0WU
OAW-42 NH3WVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIryTWFKSzVyPUKuNFk4OTFizszN NUG4TZREW0GQR1XS
LB996-RCC M1Hvbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJwMUO4NVch|ryP MX;TRW5ITVJ?
COR-L105 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjHOYtKSzVyPUKuNVY{PzNizszN MV\TRW5ITVJ?
RCC10RGB MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJwMUi1O|Yh|ryP NXXqPYdXW0GQR1XS
A431 NFfzZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;COGlEPTB;Mj6xPVAyQSEQvF2= Ml;sV2FPT0WU
NCI-H292 NHvBZZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHRTWM2OD1{LkKzPVUyKM7:TR?= NE[2[ohUSU6JRWK=
SK-UT-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jHNWlEPTB;Mj6zN|E5PCEQvF2= MUnTRW5ITVJ?
PANC-08-13 M1TCc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLtRoZOUUN3ME2yMlM{OjN3IN88US=> M1HLVnNCVkeHUh?=
ST486 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln5TWM2OD1{LkSxNFQ5KM7:TR?= NXrZ[WFyW0GQR1XS
SJSA-1 MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rwZWlEPTB;Mj60NVI4OSEQvF2= NGXWdmhUSU6JRWK=
RKO MnPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfMTWM2OD1{LkSyNFI6KM7:TR?= M{fBenNCVkeHUh?=
NCI-H1793 NYiwUXpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\oUVRKSzVyPUKuOFQxOjlizszN NXPkNXltW0GQR1XS
639-V NULydW5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7MNZFKSzVyPUKuOFU{QDJizszN MmfMV2FPT0WU
ES3 NF\6RoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfVTWM2OD1{LkS5O|M4KM7:TR?= M1;6b3NCVkeHUh?=
NCI-H1792 Mn3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjWcYRKSzVyPUKuOVY5OjZizszN NWLWSGk{W0GQR1XS
NCI-H1651 M4L4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJwNUiyNUDPxE1? MWfTRW5ITVJ?
SN12C NGr5UHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwNUi0PFch|ryP MmHyV2FPT0WU
COLO-679 M{HDUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPkW3ZKSzVyPUKuOVg3ODVizszN M3;xXXNCVkeHUh?=
U-118-MG NYPOTlcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHvUlNSUUN3ME2yMlU5QDd{IN88US=> MULTRW5ITVJ?
Ramos-2G6-4C10 Mn31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mom2TWM2OD1{Lk[0PFA4KM7:TR?= M4nJOHNCVkeHUh?=
HCT-15 NFjDWVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzGSpp1UUN3ME2yMlY5Pzl{IN88US=> NWK2XoQxW0GQR1XS
MDA-MB-157 NVPXfIt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLvT3RnUUN3ME2yMlcxPzR5IN88US=> NWn2VXJyW0GQR1XS
K5 NGHrOolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHjTWM2OD1{LkexPFQ2KM7:TR?= NVXWeIg5W0GQR1XS
MKN45 M3;ifWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SzcWlEPTB;Mj63N|M3PiEQvF2= MnrPV2FPT0WU
DMS-273 M33UfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHX[pZqUUN3ME2yMlc2PjN{IN88US=> NWPhdmxKW0GQR1XS
C8166 NWPuOVBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX5TWM2OD1{Lke4OVE{KM7:TR?= M3n2UHNCVkeHUh?=
Calu-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X6Z2lEPTB;Mj63PFk3QSEQvF2= MWDTRW5ITVJ?
SNB75 MlHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTJwOEi1N|Uh|ryP MnL4V2FPT0WU
BFTC-905 NWXiPJBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJwOUCxPVEh|ryP M4TvbHNCVkeHUh?=
C-4-II MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LLWWlEPTB;Mj65NVM2OyEQvF2= M2TyTHNCVkeHUh?=
MS-1 M3jsSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXGTJpKSzVyPUKuPVY4PjlizszN M4LPPHNCVkeHUh?=
A375 NInBPYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvpTWM2OD1|LkC4NVg1KM7:TR?= NIrjWYhUSU6JRWK=
KYSE-70 MlzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HFN2lEPTB;Mz6wPFg5OiEQvF2= NHTQN4VUSU6JRWK=
KYSE-510 M4HJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3sVY54UUN3ME2zMlExQTl3IN88US=> Mlu4V2FPT0WU
LN-405 NGnlWGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXnVGxKSzVyPUOuNVM2OThizszN MmnTV2FPT0WU
BOKU MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi0O5NKSzVyPUOuNVQzPTZizszN M1PrZ3NCVkeHUh?=
TE-10 MnjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[4XWlEPTB;Mz6xO|M3OiEQvF2= MlrBV2FPT0WU
MKN1 NGHsR5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTNwMUi0PFMh|ryP NXrhfYdqW0GQR1XS
M059J MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml64TWM2OD1|LkKwNVc{KM7:TR?= M2DmbXNCVkeHUh?=
GOTO MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHldIlEUUN3ME2zMlIzODN7IN88US=> MmntV2FPT0WU
DK-MG NHrFfnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTNwMkW5O|Yh|ryP MX7TRW5ITVJ?
NCI-H727 M3Pnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fhR2lEPTB;Mz6yOlU5KM7:TR?= M1js[XNCVkeHUh?=
NB12 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fCN2lEPTB;Mz6zN|IzPCEQvF2= NIPBdFlUSU6JRWK=
DOK NIWyNnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkWzTWM2OD1|LkO2NVg3KM7:TR?= M1nC[3NCVkeHUh?=
KYSE-410 M2LTUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDYOpZKSzVyPUOuN|YzQDdizszN NXG3b2ZwW0GQR1XS
AM-38 MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFm4cIZKSzVyPUOuN|gxPTFizszN MkjFV2FPT0WU
GR-ST MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK0WlVQUUN3ME2zMlQ2PzN{IN88US=> Ml3PV2FPT0WU
D-247MG Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWezS2dtUUN3ME2zMlQ5OjZ|IN88US=> NH;i[2ZUSU6JRWK=
TE-8 NWCwNYJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCxWpVzUUN3ME2zMlQ6OzN|IN88US=> MnLsV2FPT0WU
LS-411N Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v0W2lEPTB;Mz60PVY6OiEQvF2= NWrnTXB4W0GQR1XS
SK-MES-1 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNwNU[0N|Mh|ryP MnzEV2FPT0WU
SF295 M3XHSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTNwNkG1OVIh|ryP NY\TW|U{W0GQR1XS
SK-MEL-30 M3;iTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV2xRXBoUUN3ME2zMlY2QTJzIN88US=> M1TmZXNCVkeHUh?=
LB2241-RCC NGDZU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu0fmxTUUN3ME2zMlY3OjZizszN NUL3[lFyW0GQR1XS
PC-14 NHy4W49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfvTWM2OD1|Lk[2OFM4KM7:TR?= M{jOdXNCVkeHUh?=
EW-7 NEf5VIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvBbGFKSzVyPUOuOlc3QTNizszN NVXzZWVKW0GQR1XS
NMC-G1 M2XKNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFezbpRKSzVyPUOuO|E5OzdizszN M2rIS3NCVkeHUh?=
TE-441-T NVfXTZNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL0TJhOUUN3ME2zMlc{ODJ6IN88US=> NVryfopqW0GQR1XS
NCI-H1618 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTNwOEG4O|Uh|ryP MnnvV2FPT0WU
PANC-03-27 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPPZ4tKSzVyPUOuPFE6OTZizszN NXXEeWNrW0GQR1XS
NCI-H2228 M1\uXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLHOJNiUUN3ME2zMlg{OTJ4IN88US=> NUPhWWh5W0GQR1XS
CAPAN-1 NIf2TmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\3cYhKSzVyPUOuPFcxODlizszN M3H2PHNCVkeHUh?=
KLE MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r5R2lEPTB;Mz65NFY4KM7:TR?= MkDzV2FPT0WU
Becker M4Ttdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zNNmlEPTB;Mz65Nlg1QSEQvF2= NVjNXYtPW0GQR1XS
SK-PN-DW Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTRwMEe5O|Qh|ryP MnrmV2FPT0WU
Hs-578-T M4Dy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm5OY1{UUN3ME20MlA5OzB4IN88US=> MXXTRW5ITVJ?
RS4-11 M1O1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWryWoprUUN3ME20MlEyOjV3IN88US=> NIrHTFlUSU6JRWK=
D-502MG M2jQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{mwV2lEPTB;ND6xOlk6PyEQvF2= NX30cI5GW0GQR1XS
GI-1 M4XGVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX2wXI84UUN3ME20MlI5Ojl7IN88US=> NFfIeXpUSU6JRWK=
NCI-H209 NF;ycIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fhd2lEPTB;ND6zN|c5KM7:TR?= NFPVOHVUSU6JRWK=
SK-OV-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTRwNEixOFkh|ryP NFfWSXpUSU6JRWK=
LOUCY MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESyToJKSzVyPUSuOFg1OzJizszN MkLGV2FPT0WU
NCI-H69 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTRwNUG3PVMh|ryP NF;5bG1USU6JRWK=
SCC-9 NEfm[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoSyTWM2OD12LkWzNVczKM7:TR?= NEnEco1USU6JRWK=
NCI-H526 NFGxVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP0[VRKSzVyPUSuOVkzQTNizszN M17ROXNCVkeHUh?=
NCI-H2170 MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf4e5JKSzVyPUSuOlY4PzFizszN M3vXdHNCVkeHUh?=
SR MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfDfZhKSzVyPUSuO|AxPDhizszN NEfrWIlUSU6JRWK=
CMK NYq4TI8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jiVmlEPTB;ND63NlExOSEQvF2= NGDCWFBUSU6JRWK=
COLO-829 M1ThWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTRwN{ewOFMh|ryP MXzTRW5ITVJ?
HuO-3N1 M{W5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT6TWM2OD12LkizNlgyKM7:TR?= M3vubnNCVkeHUh?=
5637 M3;PTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3GyTWlEPTB;ND65NFQ5PyEQvF2= M2rSNnNCVkeHUh?=
A253 NWGyWXR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn64TWM2OD12Lkm3O|A5KM7:TR?= MkW2V2FPT0WU
NB10 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTVwMEe0PVch|ryP NGDsNnhUSU6JRWK=
SF539 NGHmUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XOUmlEPTB;NT6wPVk2QSEQvF2= M4fxZXNCVkeHUh?=
HAL-01 NYrHUmZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf2TWM2OD13LkG0OlQ2KM7:TR?= M4W2fXNCVkeHUh?=
MHH-ES-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX1TWFMUUN3ME21MlE3QTJ3IN88US=> NIjocWxUSU6JRWK=
DEL Mn;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXpTWM2OD13LkK3OVgzKM7:TR?= NEPTN2tUSU6JRWK=
NCI-H1299 NYXye|V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XvbGlEPTB;NT6zOVAxPyEQvF2= NHzDbmZUSU6JRWK=
ChaGo-K-1 NXfwPXNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XOWmlEPTB;NT6zOVExPyEQvF2= NIDZdmRUSU6JRWK=
HMV-II M2P4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTVwM{m0N{DPxE1? MUHTRW5ITVJ?
NB69 M3jESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV71W5JzUUN3ME21MlM6PjNzIN88US=> MlzpV2FPT0WU
NCI-H1882 NEjDOnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrYVJpKSzVyPUWuOFM{PjRizszN M4noUXNCVkeHUh?=
SNU-475 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTVwNEexO|Eh|ryP MWHTRW5ITVJ?
RXF393 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXPc4Y{UUN3ME21MlQ5PDl2IN88US=> Ml3oV2FPT0WU
CAL-51 NGDoWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2P4cmlEPTB;NT62Nlg2OyEQvF2= M2m0UnNCVkeHUh?=
SW1573 NGe2O5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTVwNkO1N|Qh|ryP MmPIV2FPT0WU
GCT NV\CWFA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPvS5hKSzVyPUWuO|U6OjlizszN M2j1O3NCVkeHUh?=
COR-L88 NYjBbW5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP6TWM2OD13Lke2PFQ3KM7:TR?= NFfLfYpUSU6JRWK=
MDA-MB-134-VI MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3HZ|RKSzVyPUWuPFc2OzZizszN M{LadXNCVkeHUh?=
NB5 MonMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjnSWM4UUN3ME21MlkzPDRizszN M1\WOXNCVkeHUh?=
GMS-10 NFuwSYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjFTWM2OD13Lkm2PFYyKM7:TR?= Mn7sV2FPT0WU
CHP-212 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL5TWM2OD14LkS4NlY4KM7:TR?= MnjMV2FPT0WU
TE-11 NWXBd4FDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTZwNUWxPFIh|ryP NUn1V3QzW0GQR1XS
SW962 NWjhbYMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X3NWlEPTB;Nj62OVc4PCEQvF2= M3ztdHNCVkeHUh?=
MZ2-MEL NWfoc2FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTZwOEKwNVEh|ryP MYrTRW5ITVJ?
C-33-A MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2T6XGlEPTB;Nj65NVY5QCEQvF2= M{HkPHNCVkeHUh?=
IGR-1 M1v1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\0OGtjUUN3ME22Mlk4QDJ4IN88US=> MWHTRW5ITVJ?
MOLT-4 NYLn[|dqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnpTWM2OD15LkG1OFA3KM7:TR?= M2TSSXNCVkeHUh?=
NCI-H1650 Ml;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LHPWlEPTB;Nz6yO|A1PiEQvF2= MojuV2FPT0WU
AsPC-1 NITkPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWP5TI1GUUN3ME23MlI5PjB3IN88US=> M173UHNCVkeHUh?=
SNU-C2B MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG0TWM2OD15LkK5OVcyKM7:TR?= MkH4V2FPT0WU
MKN7 NGHyeJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzNN3U4UUN3ME23MlM4OjN3IN88US=> NXzveI5kW0GQR1XS
SW620 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmeyTWM2OD15LkO4NlA2KM7:TR?= NFTFWFhUSU6JRWK=
SK-MEL-28 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3pTWM2OD15LkSwO|k5KM7:TR?= Mmj1V2FPT0WU
TE-6 NXXrNmpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrJTWM2OD15LkS0PVA5KM7:TR?= MkPkV2FPT0WU
D-263MG NHLQXpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfwU|k6UUN3ME23MlQ2PzZ{IN88US=> MYrTRW5ITVJ?
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HCE-T MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTPfnh3UUN3ME2yNk45PjB4IN88US=> NGPnOmFUSU6JRWK=
BB65-RCC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm0TWM2OD1{Mz6wN|Q1KM7:TR?= NYDKcJJGW0GQR1XS
SiHa M17NOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPRTWM2OD1{Mz6zPVY5KM7:TR?= MYnTRW5ITVJ?
NCI-H2081 M1u1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPHTWM2OD1{ND6wOlQyKM7:TR?= NH;DdWpUSU6JRWK=
U251 NILieW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\KS2lEPTB;MkSuNFY3QCEQvF2= M{XaenNCVkeHUh?=
LoVo MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJ2LkmyPFIh|ryP NUTJbotbW0GQR1XS
GCIY MlvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HRXWlEPTB;MkWuNlg4PyEQvF2= NHfyfopUSU6JRWK=
NUGC-3 NH7tS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPVTWM2OD1{NT6zN|E3KM7:TR?= MVXTRW5ITVJ?
LNCaP-Clone-FGC NWXoT|l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJ3LkO0PVgh|ryP MnHaV2FPT0WU
PA-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJ3Lk[4N|Mh|ryP MVfTRW5ITVJ?
OE33 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJ3Lk[4OVMh|ryP MWXTRW5ITVJ?
HT-29 NHvkeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PqdmlEPTB;MkWuO|g4QSEQvF2= Ml;RV2FPT0WU
RCM-1 NFv0UWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorYTWM2OD1{NT65OlU3KM7:TR?= M1XPeHNCVkeHUh?=
NCI-H1522 NI\BfWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PCcmlEPTB;MkWuPVkyOSEQvF2= M3flUHNCVkeHUh?=
LB373-MEL-D NELEdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOxTWM2OD1{Nj6xO|A5KM7:TR?= MXTTRW5ITVJ?
NCI-H1436 NYfwfIdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlG0TWM2OD1{Nj6yO|M5KM7:TR?= M4foe3NCVkeHUh?=
COLO-824 NIjTPZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj1[opKSzVyPUK2MlQxODJizszN NFP0OWtUSU6JRWK=
CP50-MEL-B MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJ4LkW2O|Uh|ryP MXHTRW5ITVJ?
EGI-1 M322PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX2TWM2OD1{Nz6yOlk5KM7:TR?= MlrsV2FPT0WU
LAN-6 NUm1cmRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJ5LkO1PVgh|ryP NEjESHlUSU6JRWK=
GAK NF3YUIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTkTWM2OD1{Nz60NlI2KM7:TR?= MWHTRW5ITVJ?
MDA-MB-175-VII M1rKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJ5LkWwOVMh|ryP NGC5fpJUSU6JRWK=
JVM-2 NVvHV2JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2O2O2lEPTB;MkeuOlYzOiEQvF2= NIjOTpJUSU6JRWK=
UACC-257 M{HKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\UcnZpUUN3ME2yO{43QDd6IN88US=> MmPXV2FPT0WU
SW1783 MkC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXkW5hKUUN3ME2yO{44Pzh|IN88US=> M3\RWnNCVkeHUh?=
HT-3 M{e0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;0RWlEPTB;MkiuNlE3PiEQvF2= Ml76V2FPT0WU
RL M37Bc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJ6LkW5NVEh|ryP MUHTRW5ITVJ?
TK10 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP6TWM2OD1{OD62OVM2KM7:TR?= M4TqenNCVkeHUh?=
HT55 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJ7LkC1OlUh|ryP MnfIV2FPT0WU
BT-20 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkeyTWM2OD1{OT6wOVg3KM7:TR?= NWXGVpBYW0GQR1XS
TGBC24TKB MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILibVNKSzVyPUK5MlE5OzFizszN NH3DWFlUSU6JRWK=
HSC-2 NFe4UGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETBUINKSzVyPUK5MlMxODFizszN Mo\ZV2FPT0WU
COLO-205 NF7mcWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn20TWM2OD1{OT6zPVQ1KM7:TR?= NIHVTG9USU6JRWK=
GT3TKB NWLzd2lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PwVWlEPTB;MkmuOlg4PyEQvF2= NFvHe5RUSU6JRWK=
T47D MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnyXJp3UUN3ME2yPU45PTh{IN88US=> M1fJNnNCVkeHUh?=
OMC-1 NGnzTVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DTRmlEPTB;M{CuNVkyQSEQvF2= M3LLSHNCVkeHUh?=
PFSK-1 NIe4coZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfZd3RKSzVyPUOxMlI3PTlizszN NETqXVZUSU6JRWK=
JEG-3 NXfVcZZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f2N2lEPTB;M{GuN|U3OSEQvF2= Mly3V2FPT0WU
RD NGn2eIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e5OGlEPTB;M{GuOVEyPSEQvF2= M4XTcHNCVkeHUh?=
NCI-H64 NFribVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofWTWM2OD1|Mj60NVc6KM7:TR?= MkXHV2FPT0WU
DMS-114 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTFN|JKSzVyPUOyMlQyQDJizszN NIfkXGRUSU6JRWK=
NCI-H661 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;TTWM2OD1|Mj62OVAyKM7:TR?= M{HieXNCVkeHUh?=
CAL-148 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iye2lEPTB;M{KuOlY3PSEQvF2= NXnDc|k3W0GQR1XS
HuP-T3 NYna[2t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEW2e3ZKSzVyPUOyMlk{OzhizszN Mn72V2FPT0WU
ES4 NXTxR|F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4f6bGlEPTB;M{OuNVcxPSEQvF2= MofCV2FPT0WU
Ca9-22 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTnclg{UUN3ME2zN{41PjBzIN88US=> NV7HZo13W0GQR1XS
LP-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fTUGlEPTB;M{SuNFkh|ryP MkPRV2FPT0WU
AU565 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y3fWlEPTB;M{SuOVA3QSEQvF2= Mk\aV2FPT0WU
MDA-MB-453 NHfTeXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Tre2lEPTB;M{WuNVQzPiEQvF2= NUPh[lZJW0GQR1XS
SNU-C1 NGXqNplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj4fnFJUUN3ME2zOU4yPzFizszN M1nzVnNCVkeHUh?=
SW13 M{npRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TTW2lEPTB;M{WuOFA4PiEQvF2= NW\MT|c4W0GQR1XS
NCI-H2122 NWnWemFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jlcWlEPTB;M{WuOVU6QCEQvF2= NH2yTohUSU6JRWK=
NCI-H1395 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfiTWM2OD1|NT62OlkyKM7:TR?= MnjaV2FPT0WU
J-RT3-T3-5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnS0TWM2OD1|Nj6wNlk1KM7:TR?= NG\MS5BUSU6JRWK=
COR-L279 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDFTWM2OD1|Nj6xPVgyKM7:TR?= NEjrSmtUSU6JRWK=
ATN-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTN4Lki1NVYh|ryP MXvTRW5ITVJ?
HCC2998 M3;SbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN4Lki1O|Eh|ryP MV\TRW5ITVJ?
UM-UC-3 MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnPWW1KSzVyPUO2Mlg3PzVizszN NXnEOFQ6W0GQR1XS
DV-90 NHfnXpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGyWIN{UUN3ME2zOk46ODZ5IN88US=> NYKwd3diW0GQR1XS
ES8 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jiOGlEPTB;M{[uPVMyQCEQvF2= MYHTRW5ITVJ?
YAPC M{PyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33MUmlEPTB;M{[uPVY2PCEQvF2= NWW1VGVlW0GQR1XS
HCC1599 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDGXG9KUUN3ME2zO{4yPjF6IN88US=> M{PGU3NCVkeHUh?=
UMC-11 NEXnbVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37le2lEPTB;M{euNlUxOyEQvF2= MXXTRW5ITVJ?
THP-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfic4pKSzVyPUO3MlI5PjhizszN NFvHU4xUSU6JRWK=
OCUB-M NEL1d|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGwPHlYUUN3ME2zO{4zQDlzIN88US=> NIXBcZJUSU6JRWK=
NCI-H1693 Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;q[WlEPTB;M{euN|I{OyEQvF2= MW\TRW5ITVJ?
NCI-H345 NYjDb3lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTN5LkO2NlQh|ryP M4TaOXNCVkeHUh?=
COLO-800 NGG4c4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml6yTWM2OD1|Nz61Olch|ryP M3W5W3NCVkeHUh?=
COLO-320-HSR NFHocYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzie5pKSzVyPUO4MlM1QTJizszN NWXRZohVW0GQR1XS
NCI-H596 NVPUZnd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTN6LkS0PFkh|ryP MXfTRW5ITVJ?
NCI-H187 NUHhUGYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TyfWlEPTB;M{iuO|M1PCEQvF2= NVjmUIFtW0GQR1XS
ECC4 NWOyWmtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTN7LkC4NVQh|ryP NWDYc2l{W0GQR1XS
KP-4 NUHLUJBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEOwR|BKSzVyPUO5MlEzOzVizszN MoXWV2FPT0WU
NCI-H2227 M{iwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{f0ZmlEPTB;M{muN|k1QSEQvF2= MV;TRW5ITVJ?
22RV1 NEf6dm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTPRnZKSzVyPUO5Mlg{QThizszN MlzSV2FPT0WU
SAS NF\H[2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fHU2lEPTB;NECuNFk3KM7:TR?= NXjxOW1GW0GQR1XS
PANC-10-05 Mn7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTRyLkG4Nlgh|ryP NU[yXFNZW0GQR1XS
MDA-MB-468 NIHQNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTRyLkWzOFYh|ryP Ml34V2FPT0WU
RPMI-7951 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3BXIVKSzVyPUSxMlIxPzVizszN Mm[wV2FPT0WU
BB49-HNC NVzUVVE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\aTmJnUUN3ME20NU4zOTd7IN88US=> M2jK[nNCVkeHUh?=
23132-87 NX;2Uot6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jTdGlEPTB;NEGuNlc{OiEQvF2= MmPTV2FPT0WU
HCC1569 M4raR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\FR4VKSzVyPUSxMlI5QDVizszN NGfFXI5USU6JRWK=
CP66-MEL MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jTOGlEPTB;NEKuNVg5PiEQvF2= MUjTRW5ITVJ?
K-562 M4nKW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjPN2VDUUN3ME20Nk4zQDV2IN88US=> M{TmfHNCVkeHUh?=
OCI-AML2 NUXq[3BiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTR{Lki5O|Qh|ryP M4D0V3NCVkeHUh?=
SW756 M2jiU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTR|LkCzPFgh|ryP NFrHcWxUSU6JRWK=
M14 M1S1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTR|LkOxPFkh|ryP MXrTRW5ITVJ?
NCI-H1623 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGToUVFKSzVyPUSzMlQ3PCEQvF2= MWjTRW5ITVJ?
KNS-81-FD MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGzTWM2OD12Mz63OlIh|ryP NFzRXGFUSU6JRWK=
TGBC1TKB NHeyNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PQbWlEPTB;NEOuPVA6QSEQvF2= NFXLXmxUSU6JRWK=
RERF-LC-MS MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTR|LkmyPFEh|ryP NHrxZ45USU6JRWK=
PC-3 M2C4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG5TWM2OD12ND60N|Q4KM7:TR?= MYXTRW5ITVJ?
HuP-T4 NGLlNHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTR2LkS0O|Qh|ryP M2jwcHNCVkeHUh?=
NCI-H510A M2\sUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\TOWM3UUN3ME20OE44ODhizszN Mnz3V2FPT0WU
LB2518-MEL NXGwNlhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LHZ2lEPTB;NESuO|k{PyEQvF2= NY\lZVNTW0GQR1XS
TE-5 NH7OeopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj1cmtKSzVyPUS1Mlk2QDFizszN MUDTRW5ITVJ?
EW-24 M1HwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDlVYxKSzVyPUS2MlE4OjNizszN MW\TRW5ITVJ?
LB647-SCLC M1zsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG2VWdKSzVyPUS2MlIyPTVizszN NGru[XBUSU6JRWK=
NCI-H524 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PjRmlEPTB;NE[uO|E5PSEQvF2= NHnQPG5USU6JRWK=
EW-11 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm3WZhKSzVyPUS2Mlk{PzNizszN NEPGd3hUSU6JRWK=
KALS-1 NHrpT4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvYOG9rUUN3ME20O{4zODZ4IN88US=> NYrUUmtxW0GQR1XS
BT-474 M4nXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnmyTWM2OD12Nz60NlE3KM7:TR?= M3:yUXNCVkeHUh?=
SK-N-AS NIDzSZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PWcGlEPTB;NEeuPFg5KM7:TR?= MUXTRW5ITVJ?
HCC2157 Ml;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHq1[WtKSzVyPUS4MlA4PiEQvF2= NEfBUIhUSU6JRWK=
HCC1954 MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzId41KSzVyPUS4MlE4ODRizszN NXW1ZVhIW0GQR1XS
FADU NFjVN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zFXmlEPTB;NEiuN|A{OSEQvF2= MYXTRW5ITVJ?
S-117 NWnrW3c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTR6LkO4NVUh|ryP MnvlV2FPT0WU
LS-1034 M1LQO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f6[mlEPTB;NEiuO|A3PyEQvF2= MlTGV2FPT0WU
CAMA-1 M2Dj[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;5fJo3UUN3ME20PU42PTR|IN88US=> MUfTRW5ITVJ?
LU-134-A M3rhXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HXZ2lEPTB;NEmuPFA5PSEQvF2= M{SxdXNCVkeHUh?=
NCI-H1838 NH\WRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37BXWlEPTB;NEmuPFA5PyEQvF2= MXrTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]
臨床試験 AP24534 is currently under Phase II clinical trials in treatment with leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Peptide substrate phosphorylation assays with GST-Abl kinase domains The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.

細胞アッセイ: [2]

細胞株 Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
濃度 0-625 nM
反応時間 72 hours
実験の流れ Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat

動物実験: [1]

動物モデル Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
製剤 Dissolved in 25 mM citrate buffer, pH 2.75
投薬量 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
投与方法 Oral gavage once daily

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Ponatinib (AP24534) SDF
分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 3-(2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

文献中の引用 (25)

Frequently Asked Questions

  • Question 1
    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

    Answer: Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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