Ponatinib (AP24534) 化学構造
分子量: 532.56

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製品説明

  • Compare Bcr-Abl Inhibitors
    Bcr-Abl製品生物活性の比較
  • 研究分野
  • Ponatinib (AP24534)のメカニズム

製品の説明

生物活性

製品説明 Ponatinib (AP24534) は、PI3KγとPI4KIIIβの新しくて強力な阻害剤で、IC50 がそれぞれ16 nM と 19 nMになる。
ターゲット Abl PDGFRα VEGFR2 FGFR1 Src
IC50 0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM [1]
In vitro試験 AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33De2lEPTB;MD6wNFAxODByM{W5JO69VQ>? M2jiS3NCVkeHUh?=
MV-4-11 NELpcY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHniXFhKSzVyPUCuNFAxODl3NjFOwG0> MVTTRW5ITVJ?
MEG-01 NVnhbo9OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMECwNVI5KM7:TR?= NFTsdXJUSU6JRWK=
LAMA-84 NYPPSVJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ToPGlEPTB;MD6wNFAyPjVizszN M4L3N3NCVkeHUh?=
CGTH-W-1 M3zMfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMECxOlkh|ryP NH;vN3NUSU6JRWK=
KASUMI-1 MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fYOWlEPTB;MD6wNFIyPyEQvF2= NX;3fFYyW0GQR1XS
BE-13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnsPJBKSzVyPUCuNFAzPTlizszN MV;TRW5ITVJ?
CTV-1 NULOSXR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK2TWM2OD1yLkCwOVIyKM7:TR?= NYrKdFl7W0GQR1XS
NKM-1 M4\UV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMEC2OVUh|ryP NHLTdnNUSU6JRWK=
MONO-MAC-6 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe3XWNKSzVyPUCuNFA5OzdizszN M2Dre3NCVkeHUh?=
A204 M3OxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjsZpJKSzVyPUCuNFEzOThizszN MojmV2FPT0WU
GDM-1 M363fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEG4N|Mh|ryP MmTMV2FPT0WU
AN3-CA NGnHcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXHTWM2OD1yLkCxPFc{KM7:TR?= NYjxfXM{W0GQR1XS
BL-70 NGPtOnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEKxPVkh|ryP NFLkWFlUSU6JRWK=
Daudi M2Tpcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkj0TWM2OD1yLkCyOVM4KM7:TR?= M1fkRXNCVkeHUh?=
KU812 NGThfFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX1T3RqUUN3ME2wMlAzQDR6IN88US=> MmrYV2FPT0WU
KG-1 NH7FelZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnD[nlKSzVyPUCuNFMzQTRizszN MXTTRW5ITVJ?
DOHH-2 NXviO4t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMES4NFMh|ryP NHnoS3NUSU6JRWK=
HuO9 MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnSyTWM2OD1yLkC1OFQ5KM7:TR?= MmjtV2FPT0WU
EB2 NEH4PYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPBVVgyUUN3ME2wMlA2PTd4IN88US=> MVTTRW5ITVJ?
G-402 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y0bmlEPTB;MD6wOlM1OSEQvF2= MYjTRW5ITVJ?
SU-DHL-1 MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7MTWM2OD1yLkC2N|c6KM7:TR?= MnfVV2FPT0WU
NCI-H719 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEe4PFgh|ryP MXfTRW5ITVJ?
MLMA M2rMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEmwOkDPxE1? NF\mc25USU6JRWK=
KM12 MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL4[np4UUN3ME2wMlA6PzN5IN88US=> MWXTRW5ITVJ?
SUP-T1 M3;QV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULO[nlCUUN3ME2wMlA6QTh{IN88US=> MVnTRW5ITVJ?
MZ1-PC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r0UWlEPTB;MD6xNVM{PiEQvF2= M2r4VHNCVkeHUh?=
MFE-296 Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMUG4N|kh|ryP NVjtbVRGW0GQR1XS
ALL-PO M4G1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVyw[mlTUUN3ME2wMlEzPDR|IN88US=> MV3TRW5ITVJ?
GB-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;sS|RKSzVyPUCuNVI2OTJizszN MVXTRW5ITVJ?
SIG-M5 NWHYV3ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nsUmlEPTB;MD6xN|M4KM7:TR?= MlfqV2FPT0WU
P30-OHK MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGriN2hKSzVyPUCuNVU3PzJizszN NHfsU|hUSU6JRWK=
NCI-H716 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPyNI52UUN3ME2wMlE3OjZ4IN88US=> NGO5b2FUSU6JRWK=
MPP-89 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj3XVlKSzVyPUCuNVY6OzNizszN NH;QVYdUSU6JRWK=
SF126 NXXHV5Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMUewOlMh|ryP Mmr3V2FPT0WU
CTB-1 Mn7SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK2SY1KSzVyPUCuNVc{OTZizszN NGnuT4pUSU6JRWK=
CA46 M1HMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorqTWM2OD1yLkG3OFg6KM7:TR?= NVPF[HQ5W0GQR1XS
NCI-H520 NH32fFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELq[IpKSzVyPUCuNVc4OzJizszN M1LYU3NCVkeHUh?=
CAL-85-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMUe5Nlch|ryP MUfTRW5ITVJ?
NCI-H2342 NH7uS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfTTWM2OD1yLkG4OVc4KM7:TR?= NGL6cnhUSU6JRWK=
697 M1exTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\2Z3c2UUN3ME2wMlE5QDdzIN88US=> NGDVSFFUSU6JRWK=
NY MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMUmyPFch|ryP Mn3CV2FPT0WU
T98G M4HQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrQV|htUUN3ME2wMlE6OzF6IN88US=> NXvaNlhYW0GQR1XS
NCI-H1703 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XvSWlEPTB;MD6xPVYyPSEQvF2= MlK0V2FPT0WU
NCI-H2087 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPlXW9iUUN3ME2wMlIxPDN7IN88US=> NIfaXINUSU6JRWK=
PF-382 NH3xXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMkC4O|Mh|ryP MnTpV2FPT0WU
HCT-116 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17xdmlEPTB;MD6yNVA3QSEQvF2= NU\tWW85W0GQR1XS
CAKI-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvSTWM2OD1yLkKxOlY3KM7:TR?= NGL0[mdUSU6JRWK=
CCF-STTG1 MmPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjSTWM2OD1yLkKyOFc2KM7:TR?= M1j5TXNCVkeHUh?=
D-392MG Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T3PGlEPTB;MD6yN|E4PyEQvF2= Mnq2V2FPT0WU
RT-112 NGfld2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDObm9KSzVyPUCuNlM4QTVizszN MmDDV2FPT0WU
MES-SA NYTBO2hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nCcmlEPTB;MD6yOFE5PyEQvF2= MmOwV2FPT0WU
LC-2-ad M33obWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rGNmlEPTB;MD6yOFI3PSEQvF2= NIG0eXVUSU6JRWK=
NOS-1 M1rJPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGOzWHlKSzVyPUCuNlQ{PjdizszN MnH2V2FPT0WU
NALM-6 M{fLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v0emlEPTB;MD6yOVU1OyEQvF2= Mo\xV2FPT0WU
TE-15 NYTu[XZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILobHJKSzVyPUCuNlYxQTFizszN MUXTRW5ITVJ?
786-0 NXO4O3FiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmw[IY2UUN3ME2wMlI3OjJ6IN88US=> Mkf3V2FPT0WU
IST-MES1 NHjlSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMk[4Nlkh|ryP NEW3[3ZUSU6JRWK=
KYSE-180 NYnnXGZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfB[3V{UUN3ME2wMlI3QDlzIN88US=> NWL6O4FLW0GQR1XS
YT NV\NTY1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PpemlEPTB;MD6yOlk4PCEQvF2= NEPFTYtUSU6JRWK=
A427 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHf4dHhKSzVyPUCuNlczPjRizszN M4TQXXNCVkeHUh?=
KYSE-450 NVzr[2pTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3QTWM2OD1yLkK3N|I6KM7:TR?= NHvKXnVUSU6JRWK=
HuH-7 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK4W3JWUUN3ME2wMlI4PzZ|IN88US=> MkfDV2FPT0WU
CAS-1 NHm5SIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIm3fWxKSzVyPUCuNlg{ODNizszN NETST5pUSU6JRWK=
KURAMOCHI MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMki0NVkh|ryP MUDTRW5ITVJ?
ACHN NX\jT5d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIi1PIFKSzVyPUCuNlk{OjNizszN MVvTRW5ITVJ?
HGC-27 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\1WmlEPTB;MD6yPVM2OyEQvF2= M3H3bnNCVkeHUh?=
A172 NF36bHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMkm1O|ch|ryP NWTmd4FqW0GQR1XS
SNU-449 NFm0RnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjlU3htUUN3ME2wMlI6QTZ2IN88US=> NEC1T3RUSU6JRWK=
SW982 MnLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXhTWM2OD1yLkK5PVc5KM7:TR?= NV2yemlGW0GQR1XS
EFO-21 M2XyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\ONmFKSzVyPUCuN|A1OTFizszN NVfqVGFVW0GQR1XS
NCI-H2030 NXXy[mdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwM{GxOlQh|ryP NH7rO|dUSU6JRWK=
HT-144 NV;qdnV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHkdYYzUUN3ME2wMlMyOjhizszN MmrzV2FPT0WU
MFE-280 NYW5OIhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;TcWlEPTB;MD6zNVQ2OyEQvF2= NIraTY1USU6JRWK=
SK-LU-1 NX[1W3FLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LBbmlEPTB;MD6zNVQ3PiEQvF2= NV[xcoZZW0GQR1XS
NCI-H2052 M1T0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\oTWM2OD1yLkOxOFg1KM7:TR?= NVfLSlVuW0GQR1XS
SK-HEP-1 NIfVSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKxeIR3UUN3ME2wMlM{OzZ6IN88US=> M4fXOHNCVkeHUh?=
QIMR-WIL NIrN[FNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfLVVFKSzVyPUCuN|M1OjRizszN NV7HO4hrW0GQR1XS
A2780 NUnKe|BlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[yNHhKSzVyPUCuN|Q{ODRizszN MXfTRW5ITVJ?
ACN Mn;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwM{S4O|Mh|ryP MVrTRW5ITVJ?
BxPC-3 M2HTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\4TWM2OD1yLkO0PVg6KM7:TR?= MUTTRW5ITVJ?
BCPAP Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwM{[wNFEh|ryP M4jBeHNCVkeHUh?=
HOP-62 M1vOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXjTWM2OD1yLkO2NVA3KM7:TR?= M3XsVHNCVkeHUh?=
SW1710 NUPCXWloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwM{[0OVUh|ryP MlvYV2FPT0WU
OPM-2 M37ZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjjTWM2OD1yLkO2OFc{KM7:TR?= NXnXPXNNW0GQR1XS
DBTRG-05MG MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\LU2lEPTB;MD6zPFA2PCEQvF2= NFOzOI1USU6JRWK=
SK-MEL-24 Moi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvSTWM2OD1yLkO5O|kyKM7:TR?= NHrJXFNUSU6JRWK=
8305C M3vsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoD4TWM2OD1yLkO5O|k{KM7:TR?= M1:0ZXNCVkeHUh?=
OVCAR-4 M3jzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwNEG1PFYh|ryP MVfTRW5ITVJ?
HLE MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j3W2lEPTB;MD60NVg3KM7:TR?= MlLFV2FPT0WU
NCI-H747 NUL0NmVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwNEKxN|ch|ryP M2fQdXNCVkeHUh?=
SW780 NXfCUJV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwNEKzOFYh|ryP M1fO[3NCVkeHUh?=
KYSE-150 NXzuZpFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;pephKSzVyPUCuOFI1OTVizszN NVvqTYkxW0GQR1XS
H4 NXHUNW9{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWSyTm5YUUN3ME2wMlQzPDVzIN88US=> NVrEOplsW0GQR1XS
SW1088 NF7VPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwNESzPUDPxE1? M1jtbHNCVkeHUh?=
SF268 NEX5PIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H2fmlEPTB;MD60OFg3KM7:TR?= NHvLS2RUSU6JRWK=
RT4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwNEWxNVEh|ryP MWLTRW5ITVJ?
NCI-H522 MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwNEWyO{DPxE1? MlTGV2FPT0WU
LCLC-97TM1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfl[ppoUUN3ME2wMlQ3OTl3IN88US=> MlvvV2FPT0WU
CAL-39 MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwNE[1NVkh|ryP M{PKbnNCVkeHUh?=
CAL-120 NFT0OXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1r5WGlEPTB;MD60O|Y1OyEQvF2= MVvTRW5ITVJ?
ESS-1 M1\vOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwNEe4NlEh|ryP NGDuZXZUSU6JRWK=
KARPAS-45 M135bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3DTWM2OD1yLkS4PVM{KM7:TR?= NXPJ[WZYW0GQR1XS
DU-4475 NHHEXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rhNWlEPTB;MD60PVUyOSEQvF2= MWjTRW5ITVJ?
VMRC-RCZ NWnxXmRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwNEm5NFQh|ryP NVLJT4ZUW0GQR1XS
HOS MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPkTWM2OD1yLkWwN|Y2KM7:TR?= NXfFZmduW0GQR1XS
MOLT-16 M4fR[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3qTWM2OD1yLkWxPFA5KM7:TR?= MkGxV2FPT0WU
RPMI-6666 M3LTNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDjTWM2OD1yLkWyNVM2KM7:TR?= NVT2[XlnW0GQR1XS
K052 Mon3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LqUGlEPTB;MD61NlE1KM7:TR?= NG\vNXFUSU6JRWK=
EHEB MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwNUKxPFIh|ryP NIm5eVJUSU6JRWK=
MFH-ino NVfNfFBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET5T3VKSzVyPUCuOVI{PTFizszN M1rJOXNCVkeHUh?=
A4-Fuk NEPtTYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwNUK1Nlgh|ryP NGPqVHdUSU6JRWK=
SW1417 NFnjcldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnyT|RlUUN3ME2wMlUzPzhzIN88US=> NIXxb|JUSU6JRWK=
DoTc2-4510 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHpdJFkUUN3ME2wMlU1QTV6IN88US=> MY\TRW5ITVJ?
TE-12 M1S0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnCTWM2OD1yLkW1O|M2KM7:TR?= M{fib3NCVkeHUh?=
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U-698-M M4XZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnixTWM2OD1yLkexNFY{KM7:TR?= MVvTRW5ITVJ?
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8505C M1vMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fhcGlEPTB;MD63Nlc1OSEQvF2= MkLZV2FPT0WU
HUTU-80 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj5TWM2OD1yLkezN|Q6KM7:TR?= MlzhV2FPT0WU
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CAL-12T MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{GyWGlEPTB;MD63N|g4PyEQvF2= MoTtV2FPT0WU
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HPAF-II MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\rd49GUUN3ME2wMlc4PTBzIN88US=> NWOxWlVzW0GQR1XS
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HT-1376 M1KwSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\tTWM2OD1yLki2NFUyKM7:TR?= NVO3RYVqW0GQR1XS
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HuCCT1 M2HzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXWRoZKSzVyPUCuPFk2PDhizszN NF\aNm5USU6JRWK=
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NCI-H2347 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3m2RmlEPTB;MD65N|I6OiEQvF2= MXzTRW5ITVJ?
G-401 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwOUO2PVUh|ryP MoDnV2FPT0WU
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KE-37 NHT1fVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULaSGR5UUN3ME2wMlk3Ozh5IN88US=> M1jlb3NCVkeHUh?=
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ML-2 NUnZUo5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwOUm3OUDPxE1? M1fYeXNCVkeHUh?=
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KYSE-520 NHTiZXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLzTWM2OD1zLkCwOFk1KM7:TR?= NX3oOGljW0GQR1XS
HL-60 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XNV2lEPTB;MT6wNFk4KM7:TR?= MV3TRW5ITVJ?
HDLM-2 NH:xSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTFwMEGyOVIh|ryP MUHTRW5ITVJ?
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MG-63 M3XFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf6UGNUUUN3ME2xMlAzPjF4IN88US=> NVHyVIlGW0GQR1XS
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CAL-54 M3[1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;KTWM2OD1zLkCzPVU6KM7:TR?= M4W3fXNCVkeHUh?=
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HCE-4 NYHNWGF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7NXJg{UUN3ME2xMlA6Ojh4IN88US=> MWjTRW5ITVJ?
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MHH-NB-11 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe4[4pKSzVyPUGuNVU{PjhizszN NFe3NWJUSU6JRWK=
NCI-H2405 NVfDTFRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfRRnMyUUN3ME2xMlE3OTZizszN NF;F[nRUSU6JRWK=
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IMR-5 M3PYe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jrbWlEPTB;MT6xOlk{PiEQvF2= NUD3TYJ[W0GQR1XS
ARH-77 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\YTWM2OD1zLkKyPVI1KM7:TR?= MkfoV2FPT0WU
BHT-101 NHG2ZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jxOmlEPTB;MT6yN|Q6KM7:TR?= NIr3SG5USU6JRWK=
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MKN28 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4f1fGlEPTB;MT6yOVY{PiEQvF2= MULTRW5ITVJ?
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NCI-H1734 NYXHXm84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mwe2lEPTB;MT6yPFkyOyEQvF2= Mmj3V2FPT0WU
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NCI-H838 M{X1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DoWmlEPTB;MT6zNFYyPSEQvF2= NWfzTHAzW0GQR1XS
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ME-180 M{LEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFwM{e5PVMh|ryP NYHuTpFSW0GQR1XS
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IA-LM MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLic4ZrUUN3ME2xMlQxQTF2IN88US=> MV;TRW5ITVJ?
MN-60 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT3TWM2OD1zLkSzNVE1KM7:TR?= Mk\GV2FPT0WU
SIMA NUTUNWpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXnNHRKSzVyPUGuOFg3QDdizszN M1rIOHNCVkeHUh?=
NCI-H1770 NYHTeYlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFwNUKwOVQh|ryP M37BeXNCVkeHUh?=
ONS-76 NWTqWoRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HlbWlEPTB;MT61NlMyOSEQvF2= NIH5cWtUSU6JRWK=
LB771-HNC M3jINmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD4TWM2OD1zLkWzPVA3KM7:TR?= MVrTRW5ITVJ?
SW48 NHLXT29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTFwNUSyOFMh|ryP Mn3MV2FPT0WU
KYSE-140 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrER5VXUUN3ME2xMlU2PzRzIN88US=> M3LNVHNCVkeHUh?=
SW626 MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYiyfVJMUUN3ME2xMlU5OTZizszN NEPrTpdUSU6JRWK=
MC-CAR NHrzbo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLRTWM2OD1zLkW4OlY{KM7:TR?= M2DF[XNCVkeHUh?=
D-336MG MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFwNkK5OEDPxE1? MojLV2FPT0WU
SK-MEL-3 MoS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES4NZVKSzVyPUGuOlM6ODJizszN Mlj6V2FPT0WU
MHH-PREB-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nFXmlEPTB;MT62OFQ4OyEQvF2= M4fnfnNCVkeHUh?=
Calu-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHwPWNPUUN3ME2xMlY2Ozh4IN88US=> MWPTRW5ITVJ?
HCC1806 M1:2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFwNk[2NVEh|ryP NVS4b|F1W0GQR1XS
A101D NEPye4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTSTWM2OD1zLk[2O|gyKM7:TR?= NXTITFBVW0GQR1XS
A704 M2H4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jpVGlEPTB;MT62PFMyOSEQvF2= MkTGV2FPT0WU
LB831-BLC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS3ZWtKSzVyPUGuOlk5PTRizszN MVHTRW5ITVJ?
RL95-2 M1y1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\hN5ZoUUN3ME2xMlcyPDZ|IN88US=> NFX6clRUSU6JRWK=
RPMI-2650 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDjS4lKSzVyPUGuO|I4OTlizszN M2rpNnNCVkeHUh?=
NH-12 NF7uV2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fvN2lEPTB;MT63N|QzPyEQvF2= Mnu2V2FPT0WU
AGS NEHLNJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFwN{[zOVgh|ryP M2\H[HNCVkeHUh?=
NEC8 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3VSIJKSzVyPUGuO|g6QTVizszN MlvtV2FPT0WU
NCI-H2009 NHPSV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFwN{m3NlEh|ryP Mni4V2FPT0WU
A498 NIH2RW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn5TWM2OD1zLkixNlgzKM7:TR?= NHXoOoVUSU6JRWK=
NCI-H810 NYm1VHBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3juTmlEPTB;MT64NVYxPiEQvF2= MlXKV2FPT0WU
SK-NEP-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmWyTWM2OD1zLkizO|Y4KM7:TR?= NEjVZlJUSU6JRWK=
D-542MG NH3SOIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFwOEW4OVEh|ryP NGTlN|lUSU6JRWK=
KNS-42 NGjUN4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv0TWM2OD1zLki2NlY3KM7:TR?= NWrRfIs5W0GQR1XS
NCI-H2452 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDiOHZWUUN3ME2xMlg6ODd2IN88US=> NHHqb5FUSU6JRWK=
SK-MEL-2 NVjFUI1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnodZZKSzVyPUGuPVAzPzFizszN NIm2SoxUSU6JRWK=
OVCAR-5 NYfHRYU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXPVFF1UUN3ME2xMlkxPjd3IN88US=> M{nF[XNCVkeHUh?=
SNG-M NH\TUZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonuTWM2OD1zLkm1PFU5KM7:TR?= NWrOdWNbW0GQR1XS
A673 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf6[pU2UUN3ME2xMlk4PTF4IN88US=> NYWwOWVPW0GQR1XS
L-428 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\nNZFKSzVyPUGuPVkyPzlizszN MXfTRW5ITVJ?
KM-H2 NISzTJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPJfWEzUUN3ME2yMlAyODlizszN MYrTRW5ITVJ?
MC-IXC MortS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnpTWM2OD1{LkCyNlc{KM7:TR?= NITNXm9USU6JRWK=
COLO-678 M3vyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDHWZlKSzVyPUKuNFQzODdizszN MlTDV2FPT0WU
MEL-JUSO NWjaWZlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJwMEe4OVEh|ryP NHHQfHhUSU6JRWK=
HCC38 M4jtS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7oTVNKSzVyPUKuNFg1OzNizszN NUHMTld6W0GQR1XS
UACC-62 MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fjXmlEPTB;Mj6wPFg2PSEQvF2= NHjUOGhUSU6JRWK=
OAW-42 NF;6WIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJwMEm3NVEh|ryP NXrvW5pGW0GQR1XS
LB996-RCC MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;nXGlEPTB;Mj6xN|gyPyEQvF2= NXjuT3FWW0GQR1XS
COR-L105 M{PqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jWcGlEPTB;Mj6xOlM4OyEQvF2= MVfTRW5ITVJ?
RCC10RGB MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrkdWlrUUN3ME2yMlE5PTd4IN88US=> MX;TRW5ITVJ?
A431 NXrnb5d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXHb401UUN3ME2yMlE6ODF7IN88US=> M{fxSnNCVkeHUh?=
NCI-H292 NYC5[oZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPtPHQxUUN3ME2yMlI{QTVzIN88US=> NEX5PXNUSU6JRWK=
SK-UT-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\1[HJKSzVyPUKuN|MyQDRizszN MYHTRW5ITVJ?
PANC-08-13 NE[5cHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES1dVBKSzVyPUKuN|MzOzVizszN MXfTRW5ITVJ?
ST486 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LPeGlEPTB;Mj60NVA1QCEQvF2= M3[0fXNCVkeHUh?=
SJSA-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJwNEGyO|Eh|ryP NVqxXYN1W0GQR1XS
RKO MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n5SWlEPTB;Mj60NlAzQSEQvF2= NWnqW|I2W0GQR1XS
NCI-H1793 M1u3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJwNESwNlkh|ryP NH\reHJUSU6JRWK=
639-V M2Xh[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnKRWQ3UUN3ME2yMlQ2Ozh{IN88US=> MWjTRW5ITVJ?
ES3 M{fpNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Tab2lEPTB;Mj60PVc{PyEQvF2= MVrTRW5ITVJ?
NCI-H1792 NUC2WJJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHvTllKSzVyPUKuOVY5OjZizszN NUniWYg2W0GQR1XS
NCI-H1651 NX\afmxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVL6[Wx6UUN3ME2yMlU5OjFizszN MVLTRW5ITVJ?
SN12C M2HyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJwNUi0PFch|ryP MlfmV2FPT0WU
COLO-679 M{fCfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJwNUi2NFUh|ryP MnWxV2FPT0WU
U-118-MG MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH3S2RKSzVyPUKuOVg5PzJizszN NFHFfpBUSU6JRWK=
Ramos-2G6-4C10 NHvVV2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr6TWM2OD1{Lk[0PFA4KM7:TR?= NUnrRnh2W0GQR1XS
HCT-15 NInxSVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJwNki3PVIh|ryP MkDHV2FPT0WU
MDA-MB-157 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTxXG5kUUN3ME2yMlcxPzR5IN88US=> MkPvV2FPT0WU
K5 NX\z[5dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;ERmlEPTB;Mj63NVg1PSEQvF2= NEjhVIJUSU6JRWK=
MKN45 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPnd25KSzVyPUKuO|M{PjZizszN NFjuUYpUSU6JRWK=
DMS-273 NF\US2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfuTWM2OD1{Lke1OlMzKM7:TR?= MYHTRW5ITVJ?
C8166 MkP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPiTWM2OD1{Lke4OVE{KM7:TR?= NVXnXVUzW0GQR1XS
Calu-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYS5eppGUUN3ME2yMlc5QTZ7IN88US=> MlrBV2FPT0WU
SNB75 M3zHeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJwOEi1N|Uh|ryP NUXWeYE{W0GQR1XS
BFTC-905 NXX3Zo1IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL0XJl[UUN3ME2yMlkxOTlzIN88US=> MXjTRW5ITVJ?
C-4-II MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;tZm5oUUN3ME2yMlkyOzV|IN88US=> MWPTRW5ITVJ?
MS-1 NUDL[XVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYmwdFc6UUN3ME2yMlk3PzZ7IN88US=> NEKweYdUSU6JRWK=
A375 M3W3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fucGlEPTB;Mz6wPFE5PCEQvF2= M3jPS3NCVkeHUh?=
KYSE-70 NHTFOXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TuS2lEPTB;Mz6wPFg5OiEQvF2= Mor4V2FPT0WU
KYSE-510 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\PSWlEPTB;Mz6xNFk6PSEQvF2= MmTsV2FPT0WU
LN-405 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny5TWM2OD1|LkGzOVE5KM7:TR?= NH3GU21USU6JRWK=
BOKU M3PMbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;3S2lEPTB;Mz6xOFI2PiEQvF2= NEnlfYJUSU6JRWK=
TE-10 MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfCTWM2OD1|LkG3N|YzKM7:TR?= NWq5OIc1W0GQR1XS
MKN1 NIXyfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX1TWM2OD1|LkG4OFg{KM7:TR?= MVrTRW5ITVJ?
M059J MnHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNwMkCxO|Mh|ryP MlHVV2FPT0WU
GOTO MmnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK5SVVKSzVyPUOuNlIxOzlizszN NGO2c5NUSU6JRWK=
DK-MG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjiPFdHUUN3ME2zMlI2QTd4IN88US=> MYrTRW5ITVJ?
NCI-H727 NYHjXFRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDkXGxKSzVyPUOuNlY2QCEQvF2= MV7TRW5ITVJ?
NB12 Mo\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rJOmlEPTB;Mz6zN|IzPCEQvF2= NUHwOodQW0GQR1XS
DOK MmPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHRTWM2OD1|LkO2NVg3KM7:TR?= MYLTRW5ITVJ?
KYSE-410 MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H1UWlEPTB;Mz6zOlI5PyEQvF2= MlrwV2FPT0WU
AM-38 Mnv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTNwM{iwOVEh|ryP MYrTRW5ITVJ?
GR-ST NXvKdWFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfVV|g3UUN3ME2zMlQ2PzN{IN88US=> MVPTRW5ITVJ?
D-247MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLITWM2OD1|LkS4NlY{KM7:TR?= NHXzVWJUSU6JRWK=
TE-8 M2mxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\YbVduUUN3ME2zMlQ6OzN|IN88US=> MlrVV2FPT0WU
LS-411N NXrhNVM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTNwNEm2PVIh|ryP NHj6NWVUSU6JRWK=
SK-MES-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHUVpdKSzVyPUOuOVY1OzNizszN MWjTRW5ITVJ?
SF295 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PKZWlEPTB;Mz62NVU2OiEQvF2= MnnlV2FPT0WU
SK-MEL-30 NVTCUId7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTNwNkW5NlEh|ryP NXqz[2NCW0GQR1XS
LB2241-RCC NEXZRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTNwNk[yOkDPxE1? MoDaV2FPT0WU
PC-14 NF;oZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXUbmJKSzVyPUOuOlY1OzdizszN MX;TRW5ITVJ?
EW-7 M1n0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYryS5VwUUN3ME2zMlY4Pjl|IN88US=> MkDQV2FPT0WU
NMC-G1 NX3zbFV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojzTWM2OD1|LkexPFM4KM7:TR?= NVruNXFMW0GQR1XS
TE-441-T NWrMVnRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTNwN{OwNlgh|ryP NEPucnlUSU6JRWK=
NCI-H1618 NEW5cIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[2ZWlEPTB;Mz64NVg4PSEQvF2= NIHF[4RUSU6JRWK=
PANC-03-27 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonHTWM2OD1|LkixPVE3KM7:TR?= MXXTRW5ITVJ?
NCI-H2228 M3r4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjKXIhRUUN3ME2zMlg{OTJ4IN88US=> MVfTRW5ITVJ?
CAPAN-1 MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDhTWM2OD1|Lki3NFA6KM7:TR?= NFr5SHJUSU6JRWK=
KLE NVqxPHByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXyTWM2OD1|LkmwOlch|ryP MnrGV2FPT0WU
Becker NHHmN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfKTZFKSzVyPUOuPVI5PDlizszN Mm\wV2FPT0WU
SK-PN-DW NYH5TYJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIr3XXFKSzVyPUSuNFc6PzRizszN MoXXV2FPT0WU
Hs-578-T NETwToJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[0[ZlKSzVyPUSuNFg{ODZizszN MWTTRW5ITVJ?
RS4-11 Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[w[XpKSzVyPUSuNVEzPTVizszN MYjTRW5ITVJ?
D-502MG NVHUcpNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjsS3hVUUN3ME20MlE3QTl5IN88US=> MYnTRW5ITVJ?
GI-1 Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHOTWM2OD12LkK4Nlk6KM7:TR?= MWfTRW5ITVJ?
NCI-H209 M4\IU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHFXGpKSzVyPUSuN|M4QCEQvF2= MVPTRW5ITVJ?
SK-OV-3 MlnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPETWM2OD12LkS4NVQ6KM7:TR?= M1\BUHNCVkeHUh?=
LOUCY MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zHUWlEPTB;ND60PFQ{OiEQvF2= MVnTRW5ITVJ?
NCI-H69 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fRdWlEPTB;ND61NVc6OyEQvF2= M2rQZ3NCVkeHUh?=
SCC-9 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHVdWVKSzVyPUSuOVMyPzJizszN MWjTRW5ITVJ?
NCI-H526 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWxTWM2OD12LkW5Nlk{KM7:TR?= M125OnNCVkeHUh?=
NCI-H2170 NHPLd4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTRwNk[3O|Eh|ryP NH3RVolUSU6JRWK=
SR NXzSfVc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfGTWM2OD12LkewNFQ5KM7:TR?= NYrZOWpRW0GQR1XS
CMK M3LSUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrITnl4UUN3ME20MlczOTBzIN88US=> MUjTRW5ITVJ?
COLO-829 M4fCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLaS|NXUUN3ME20Mlc4ODR|IN88US=> MkXMV2FPT0WU
HuO-3N1 NILmdmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi5U4JuUUN3ME20Mlg{OjhzIN88US=> M{X2dnNCVkeHUh?=
5637 NEDBWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PPZWlEPTB;ND65NFQ5PyEQvF2= M4jJZnNCVkeHUh?=
A253 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTwflhKSzVyPUSuPVc4ODhizszN MmLjV2FPT0WU
NB10 M4jPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLScG43UUN3ME21MlA4PDl5IN88US=> MXfTRW5ITVJ?
SF539 NVK2ZZE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDXR2xKSzVyPUWuNFk6PTlizszN M{TWWXNCVkeHUh?=
HAL-01 NFjjTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDiTWM2OD13LkG0OlQ2KM7:TR?= MlvCV2FPT0WU
MHH-ES-1 NEP6cWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfaWFJGUUN3ME21MlE3QTJ3IN88US=> NWjBVWdqW0GQR1XS
DEL M2DXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLwdFNoUUN3ME21MlI4PTh{IN88US=> MV;TRW5ITVJ?
NCI-H1299 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnnTWM2OD13LkO1NFA4KM7:TR?= MlHiV2FPT0WU
ChaGo-K-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnZXplKSzVyPUWuN|UyODdizszN NYHLTXVWW0GQR1XS
HMV-II NEjK[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe0dng6UUN3ME21MlM6PDNizszN NYHmfnVOW0GQR1XS
NB69 M4WycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrzTWM2OD13LkO5OlMyKM7:TR?= NXTxcJFzW0GQR1XS
NCI-H1882 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC5TFVKSzVyPUWuOFM{PjRizszN M4O5UHNCVkeHUh?=
SNU-475 MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j4cmlEPTB;NT60O|E4OSEQvF2= NULzRXp7W0GQR1XS
RXF393 NHHPeJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln2TWM2OD13LkS4OFk1KM7:TR?= MX\TRW5ITVJ?
CAL-51 NU\iUJM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXOTWM2OD13Lk[yPFU{KM7:TR?= MWXTRW5ITVJ?
SW1573 MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nzeWlEPTB;NT62N|U{PCEQvF2= NWP5O2dXW0GQR1XS
GCT M4PXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnryTWM2OD13Lke1PVI6KM7:TR?= M1joZXNCVkeHUh?=
COR-L88 NVLyeWg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37PWGlEPTB;NT63Olg1PiEQvF2= MWPTRW5ITVJ?
MDA-MB-134-VI MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDFTWM2OD13Lki3OVM3KM7:TR?= MVPTRW5ITVJ?
NB5 Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rNW2lEPTB;NT65NlQ1KM7:TR?= MVLTRW5ITVJ?
GMS-10 M3vrUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOxfGFKSzVyPUWuPVY5PjFizszN MmrnV2FPT0WU
CHP-212 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLtOppKSzVyPU[uOFgzPjdizszN NXHyfW51W0GQR1XS
TE-11 MlruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXtVGFGUUN3ME22MlU2OTh{IN88US=> NFnKcnlUSU6JRWK=
SW962 M2DEV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoqxTWM2OD14Lk[1O|c1KM7:TR?= Mlj2V2FPT0WU
MZ2-MEL NXvBNlhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq5SIFMUUN3ME22MlgzODFzIN88US=> NEHMXGlUSU6JRWK=
C-33-A Mlv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX1RoZKSzVyPU[uPVE3QDhizszN M3HqcXNCVkeHUh?=
IGR-1 MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;vUmlEPTB;Nj65O|gzPiEQvF2= NWG5XI1{W0GQR1XS
MOLT-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTdwMUW0NFYh|ryP NFLLZWxUSU6JRWK=
NCI-H1650 MmDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfjRos2UUN3ME23MlI4ODR4IN88US=> M3PpdnNCVkeHUh?=
AsPC-1 NHK4VVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTdwMki2NFUh|ryP NULQNZdIW0GQR1XS
SNU-C2B MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\mfWlEPTB;Nz6yPVU4OSEQvF2= MV\TRW5ITVJ?
MKN7 NHj2enBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmmyTWM2OD15LkO3NlM2KM7:TR?= MnH5V2FPT0WU
SW620 NWq0SHJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTdwM{iyNFUh|ryP NHi5S4tUSU6JRWK=
SK-MEL-28 Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq2TWM2OD15LkSwO|k5KM7:TR?= M4rJfXNCVkeHUh?=
TE-6 NXvUc416T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\MW4pUUUN3ME23MlQ1QTB6IN88US=> MX\TRW5ITVJ?
D-263MG M2DQSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PU[mlEPTB;Nz60OVc3OiEQvF2= MWTTRW5ITVJ?
NCI-H1355 NWrGSnJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTdwN{ewNlkh|ryP M{jDZnNCVkeHUh?=
DSH1 M{SwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke5TWM2OD15Lke5O|YzKM7:TR?= NULCTIdvW0GQR1XS
NCI-H460 NXTS[oF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRThwMEC2PVQh|ryP NGfoeoxUSU6JRWK=
NCI-H1563 M1LM[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vySGlEPTB;OD6wO|UxQCEQvF2= NX\DNnhVW0GQR1XS
SW948 NV\RV21UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoD6TWM2OD16LkGwO|Q1KM7:TR?= NU\oeG5OW0GQR1XS
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LoVo MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK4blJKSzVyPUK0MlkzQDJizszN Mn;hV2FPT0WU
GCIY NEGx[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XzOmlEPTB;MkWuNlg4PyEQvF2= Mk\GV2FPT0WU
NUGC-3 NUDCeoFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDXWmxKSzVyPUK1MlM{OTZizszN NX7TV4xJW0GQR1XS
LNCaP-Clone-FGC NUGzbJFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHpNHJDUUN3ME2yOU4{PDl6IN88US=> NYTLS|ZZW0GQR1XS
PA-1 M3HvfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXMTWM2OD1{NT62PFM{KM7:TR?= MnvnV2FPT0WU
OE33 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTkO3JKSzVyPUK1MlY5PTNizszN M1n4d3NCVkeHUh?=
HT-29 M4TaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DLWGlEPTB;MkWuO|g4QSEQvF2= M4\mR3NCVkeHUh?=
RCM-1 NHrZ[VZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDMTWM2OD1{NT65OlU3KM7:TR?= NXfLS5hLW0GQR1XS
NCI-H1522 NUDxPIhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWraeHJPUUN3ME2yOU46QTFzIN88US=> M2OybXNCVkeHUh?=
LB373-MEL-D M2XyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\ORmQ3UUN3ME2yOk4yPzB6IN88US=> NITlSGZUSU6JRWK=
NCI-H1436 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH6blU2UUN3ME2yOk4zPzN6IN88US=> MWTTRW5ITVJ?
COLO-824 NIHkdpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJ4LkSwNFIh|ryP MYHTRW5ITVJ?
CP50-MEL-B NWrSb3VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD2TWM2OD1{Nj61Olc2KM7:TR?= NGjhfFdUSU6JRWK=
EGI-1 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXnOVBKSzVyPUK3MlI3QThizszN NF\sdWtUSU6JRWK=
LAN-6 NWnTOZB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqyblhKSzVyPUK3MlM2QThizszN NGLyU3FUSU6JRWK=
GAK NEnqd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3GwW2lEPTB;MkeuOFIzPSEQvF2= NWrMXVhGW0GQR1XS
MDA-MB-175-VII M{e2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T0NmlEPTB;MkeuOVA2OyEQvF2= MWHTRW5ITVJ?
JVM-2 NYTCTnJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X3TGlEPTB;MkeuOlYzOiEQvF2= MWjTRW5ITVJ?
UACC-257 NYTVN|hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm3U29EUUN3ME2yO{43QDd6IN88US=> NF3WbllUSU6JRWK=
SW1783 M3WyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJ5Lke3PFMh|ryP M{nKTHNCVkeHUh?=
HT-3 NX;qVnhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ6LkKxOlYh|ryP NHzwepZUSU6JRWK=
RL MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTnTWM2OD1{OD61PVEyKM7:TR?= NH;VbJZUSU6JRWK=
TK10 M{G1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TYfmlEPTB;MkiuOlU{PSEQvF2= MXTTRW5ITVJ?
HT55 NUf3eGc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJ7LkC1OlUh|ryP M3X4b3NCVkeHUh?=
BT-20 NFS1OXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW5fmVKSzVyPUK5MlA2QDZizszN NUXDR|J7W0GQR1XS
TGBC24TKB NFz3VHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PPR2lEPTB;MkmuNVg{OSEQvF2= MlHLV2FPT0WU
HSC-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJ7LkOwNFEh|ryP MX7TRW5ITVJ?
COLO-205 NIPIZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrYV5lKSzVyPUK5MlM6PDRizszN Ml;MV2FPT0WU
GT3TKB NIricJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfze5BzUUN3ME2yPU43QDd5IN88US=> MnfSV2FPT0WU
T47D MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3TOIc6UUN3ME2yPU45PTh{IN88US=> MmD1V2FPT0WU
OMC-1 NHSxVXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2mzZWlEPTB;M{CuNVkyQSEQvF2= MkPKV2FPT0WU
PFSK-1 NYDKOYRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfXeI1xUUN3ME2zNU4zPjV7IN88US=> Mon4V2FPT0WU
JEG-3 M2W5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTNzLkO1OlEh|ryP NV7aem9GW0GQR1XS
RD MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTNzLkWxNVUh|ryP MVHTRW5ITVJ?
NCI-H64 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHlXHJKUUN3ME2zNk41OTd7IN88US=> Ml3SV2FPT0WU
DMS-114 NWe4NlJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLQTWM2OD1|Mj60NVgzKM7:TR?= MUnTRW5ITVJ?
NCI-H661 NFr2bWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rLZ2lEPTB;M{KuOlUxOSEQvF2= M1y4bnNCVkeHUh?=
CAL-148 M3S2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4foTmlEPTB;M{KuOlY3PSEQvF2= NIP1Z|NUSU6JRWK=
HuP-T3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTN{LkmzN|gh|ryP NYjjSFNHW0GQR1XS
ES4 M2T2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnOdJFtUUN3ME2zN{4yPzB3IN88US=> NFXSPFZUSU6JRWK=
Ca9-22 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;KUGpKSzVyPUOzMlQ3ODFizszN NULVeJNiW0GQR1XS
LP-1 MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTN2LkC5JO69VQ>? M2LWPHNCVkeHUh?=
AU565 NF3ONXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFznNXlKSzVyPUO0MlUxPjlizszN NEfhR4pUSU6JRWK=
MDA-MB-453 M1roWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fjfWlEPTB;M{WuNVQzPiEQvF2= M1\GVXNCVkeHUh?=
SNU-C1 NEDuR4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf0TWM2OD1|NT6xO|Eh|ryP NHGyTXNUSU6JRWK=
SW13 M{C0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN3LkSwO|Yh|ryP M33XTnNCVkeHUh?=
NCI-H2122 NHf2PWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljQTWM2OD1|NT61OVk5KM7:TR?= MYfTRW5ITVJ?
NCI-H1395 M2f2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTN3Lk[2PVEh|ryP NXzW[Gd2W0GQR1XS
J-RT3-T3-5 NXTR[VBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoruTWM2OD1|Nj6wNlk1KM7:TR?= MnPFV2FPT0WU
COR-L279 Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\LWFVKSzVyPUO2MlE6QDFizszN NH\zZmVUSU6JRWK=
ATN-1 NYfDcHM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHsVoJKSzVyPUO2Mlg2OTZizszN NEnoT5dUSU6JRWK=
HCC2998 NULF[3RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;p[GFGUUN3ME2zOk45PTdzIN88US=> Mk\RV2FPT0WU
UM-UC-3 NUj1c2RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXZNmZKSzVyPUO2Mlg3PzVizszN M2LzVHNCVkeHUh?=
DV-90 NUXwZpBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV75V3JwUUN3ME2zOk46ODZ5IN88US=> MYjTRW5ITVJ?
ES8 MorKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LyNWlEPTB;M{[uPVMyQCEQvF2= MUDTRW5ITVJ?
YAPC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTN4Lkm2OVQh|ryP NImzdpJUSU6JRWK=
HCC1599 MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHHTWM2OD1|Nz6xOlE5KM7:TR?= MnnWV2FPT0WU
UMC-11 M4D5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j3bGlEPTB;M{euNlUxOyEQvF2= MU\TRW5ITVJ?
THP-1 NIHofYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjS[JBKSzVyPUO3MlI5PjhizszN NGS5c4hUSU6JRWK=
OCUB-M NVnxcpJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLFTWM2OD1|Nz6yPFkyKM7:TR?= MorRV2FPT0WU
NCI-H1693 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPuSVhKSzVyPUO3MlMzOzNizszN NEPq[29USU6JRWK=
NCI-H345 MlWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\sTWM2OD1|Nz6zOlI1KM7:TR?= M3j4[HNCVkeHUh?=
COLO-800 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHz[3NUUUN3ME2zO{42PjdizszN NXL2d5ptW0GQR1XS
COLO-320-HSR M3vrfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvUNJpsUUN3ME2zPE4{PDl{IN88US=> M1nIXXNCVkeHUh?=
NCI-H596 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTCW3BKSzVyPUO4MlQ1QDlizszN Ml3aV2FPT0WU
NCI-H187 NXXOWYZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vsPWlEPTB;M{iuO|M1PCEQvF2= MlyxV2FPT0WU
ECC4 M{\V[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTN7LkC4NVQh|ryP M2XlbnNCVkeHUh?=
KP-4 NVnQVFJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[4TWM2OD1|OT6xNlM2KM7:TR?= MnjyV2FPT0WU
NCI-H2227 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TPeGlEPTB;M{muN|k1QSEQvF2= NH3FTpRUSU6JRWK=
22RV1 NGfTU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfXZpBKSzVyPUO5Mlg{QThizszN M{LBSHNCVkeHUh?=
SAS NEDhO2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu3OFVXUUN3ME20NE4xQTZizszN NWW1V29PW0GQR1XS
PANC-10-05 M{mybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTSfFZPUUN3ME20NE4yQDJ6IN88US=> NVq5N5RjW0GQR1XS
MDA-MB-468 NWDqN2ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXFPIhKSzVyPUSwMlU{PDZizszN MlXjV2FPT0WU
RPMI-7951 NV3Zc3N1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL4TWM2OD12MT6yNFc2KM7:TR?= NXzuVGZ6W0GQR1XS
BB49-HNC M4r5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHzWWVKSzVyPUSxMlIyPzlizszN MVHTRW5ITVJ?
23132-87 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK2NlNmUUN3ME20NU4zPzN{IN88US=> M4\1c3NCVkeHUh?=
HCC1569 NX;GXXdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTRzLkK4PFUh|ryP MYPTRW5ITVJ?
CP66-MEL NH\EWG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{W0TWlEPTB;NEKuNVg5PiEQvF2= NVTS[lBDW0GQR1XS
K-562 NHjxNoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTR{LkK4OVQh|ryP M{\KUXNCVkeHUh?=
OCI-AML2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTR{Lki5O|Qh|ryP NEnNc45USU6JRWK=
SW756 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTaOGhKSzVyPUSzMlA{QDhizszN NHruWYhUSU6JRWK=
M14 NIfITVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTR|LkOxPFkh|ryP NYPvdXljW0GQR1XS
NCI-H1623 NFv5SIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr6cG1KSzVyPUSzMlQ3PCEQvF2= M1jYUnNCVkeHUh?=
KNS-81-FD NVLk[I84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTR|Lke2NkDPxE1? M37GPHNCVkeHUh?=
TGBC1TKB MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jyUGlEPTB;NEOuPVA6QSEQvF2= MVLTRW5ITVJ?
RERF-LC-MS NUK4T2ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTR|LkmyPFEh|ryP NFvQXJpUSU6JRWK=
PC-3 NInPdI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LBS2lEPTB;NESuOFM1PyEQvF2= NHnmWWxUSU6JRWK=
HuP-T4 NHrQSGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTR2LkS0O|Qh|ryP Mn;wV2FPT0WU
NCI-H510A NW\yNHlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHjZ3dvUUN3ME20OE44ODhizszN NHrqUpNUSU6JRWK=
LB2518-MEL NGntOXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy1XWVEUUN3ME20OE44QTN5IN88US=> M1PM[3NCVkeHUh?=
TE-5 NFvvb2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3jTWM2OD12NT65OVgyKM7:TR?= NE\QR29USU6JRWK=
EW-24 M2rPO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXiTWM2OD12Nj6xO|I{KM7:TR?= Mly5V2FPT0WU
LB647-SCLC MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LM[2lEPTB;NE[uNlE2PSEQvF2= M3vOc3NCVkeHUh?=
NCI-H524 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTR4LkexPFUh|ryP MlLoV2FPT0WU
EW-11 M{\sWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XLUmlEPTB;NE[uPVM4OyEQvF2= NHnoWYpUSU6JRWK=
KALS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3XR|JKSzVyPUS3MlIxPjZizszN NXr2c4x1W0GQR1XS
BT-474 NVXx[HFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e2SWlEPTB;NEeuOFIyPiEQvF2= NWXJW|BVW0GQR1XS
SK-N-AS MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjoN|BuUUN3ME20O{45QDhizszN MUnTRW5ITVJ?
HCC2157 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTR6LkC3OkDPxE1? NFf2eIFUSU6JRWK=
HCC1954 NVy2NYNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TKdmlEPTB;NEiuNVcxPCEQvF2= NID2NohUSU6JRWK=
FADU NIL0SXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR6LkOwN|Eh|ryP MnX3V2FPT0WU
S-117 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HaWWlEPTB;NEiuN|gyPSEQvF2= MmToV2FPT0WU
LS-1034 M1LlUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkm1TWM2OD12OD63NFY4KM7:TR?= M1;jb3NCVkeHUh?=
CAMA-1 NU\sUo9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;LVWlEPTB;NEmuOVU1OyEQvF2= NXPSbXVTW0GQR1XS
LU-134-A NYrVOYE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGxNGdKUUN3ME20PU45ODh3IN88US=> NV73dldmW0GQR1XS
NCI-H1838 NVzCUIFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmG2TWM2OD12OT64NFg4KM7:TR?= M4[zeXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]
臨床試験 AP24534 is currently under Phase II clinical trials in treatment with leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Peptide substrate phosphorylation assays with GST-Abl kinase domains The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.

細胞アッセイ: [2]

細胞株 Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
濃度 0-625 nM
反応時間 72 hours
実験の流れ Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat

動物実験: [1]

動物モデル Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
製剤 Dissolved in 25 mM citrate buffer, pH 2.75
投薬量 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
投与方法 Oral gavage once daily

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Ponatinib (AP24534) SDF
分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 3-(2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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Frequently Asked Questions

  • Question 1
    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

    Answer: Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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