Ponatinib (AP24534) 化学構造
分子量: 532.56

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製品説明

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    Bcr-Abl製品生物活性の比較
  • 研究分野
  • Ponatinib (AP24534)のメカニズム

製品の説明

生物活性

製品説明 Ponatinib (AP24534) は、PI3KγとPI4KIIIβの新しくて強力な阻害剤で、IC50 がそれぞれ16 nM と 19 nMになる。
ターゲット Abl PDGFRα VEGFR2 FGFR1 Src
IC50 0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM [1]
In vitro試験 AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell NVW1[XpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m4TGlEPTB;MD6wNFAxODByM{W5JO69VQ>? NGrrNZJUSU6JRWK=
MV-4-11 NX\SZ4VbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XxOGlEPTB;MD6wNFAxQTV4IN88US=> NEPTTmFUSU6JRWK=
MEG-01 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMECwNVI5KM7:TR?= NG\iSFFUSU6JRWK=
LAMA-84 M3rWOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHZXZJKSzVyPUCuNFAxOTZ3IN88US=> NH7yZVJUSU6JRWK=
CGTH-W-1 M2jFPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;Kd2lEPTB;MD6wNFE3QSEQvF2= MWLTRW5ITVJ?
KASUMI-1 M2q4Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzTfpBNUUN3ME2wMlAxOjF5IN88US=> NVixc2s5W0GQR1XS
BE-13 NF3TTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\BbmlEPTB;MD6wNFI2QSEQvF2= MXnTRW5ITVJ?
CTV-1 MmPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jweWlEPTB;MD6wNFUzOSEQvF2= MV7TRW5ITVJ?
NKM-1 MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLYfIRKSzVyPUCuNFA3PTVizszN M3zFRXNCVkeHUh?=
MONO-MAC-6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLETWM2OD1yLkCwPFM4KM7:TR?= MVHTRW5ITVJ?
A204 MkjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEOyfIFKSzVyPUCuNFEzOThizszN NH\iTGNUSU6JRWK=
GDM-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jCUWlEPTB;MD6wNVg{OyEQvF2= MWDTRW5ITVJ?
AN3-CA M3rEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHSV4FKSzVyPUCuNFE5PzNizszN NFnXTphUSU6JRWK=
BL-70 NH;kdHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7JT2hKSzVyPUCuNFIyQTlizszN NGHXV5lUSU6JRWK=
Daudi Moj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DBfmlEPTB;MD6wNlU{PyEQvF2= NHrJ[WhUSU6JRWK=
KU812 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjLR5dHUUN3ME2wMlAzQDR6IN88US=> M3\XN3NCVkeHUh?=
KG-1 NYrSW3NKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTjTWM2OD1yLkCzNlk1KM7:TR?= MXnTRW5ITVJ?
DOHH-2 M4m5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPzZZc5UUN3ME2wMlA1QDB|IN88US=> M1vaXHNCVkeHUh?=
HuO9 NEL0VGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PYbmlEPTB;MD6wOVQ1QCEQvF2= MYTTRW5ITVJ?
EB2 NHXPOoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7NTWM2OD1yLkC1OVc3KM7:TR?= MoTIV2FPT0WU
G-402 NFHQWmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLMc5FKSzVyPUCuNFY{PDFizszN NFf2XYVUSU6JRWK=
SU-DHL-1 NW\hSnJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnGRXFKSzVyPUCuNFY{PzlizszN M2i2cHNCVkeHUh?=
NCI-H719 Mn7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnrTWM2OD1yLkC3PFg5KM7:TR?= NFflZYlUSU6JRWK=
MLMA M1z6eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TOPWlEPTB;MD6wPVA3KM7:TR?= MXPTRW5ITVJ?
KM12 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomxTWM2OD1yLkC5O|M4KM7:TR?= MlrOV2FPT0WU
SUP-T1 NXXGXXJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHHPWVKSzVyPUCuNFk6QDJizszN MYjTRW5ITVJ?
MZ1-PC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPxTWM2OD1yLkGxN|M3KM7:TR?= NVG4T3hOW0GQR1XS
MFE-296 NIC3fnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMUG4N|kh|ryP NYTnW41uW0GQR1XS
ALL-PO NVv0NI5HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfBOJFYUUN3ME2wMlEzPDR|IN88US=> MVTTRW5ITVJ?
GB-1 NGDzR|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILxcpJKSzVyPUCuNVI2OTJizszN MmXjV2FPT0WU
SIG-M5 NWe2d3VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMUOzO{DPxE1? M17vbnNCVkeHUh?=
P30-OHK MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P1VWlEPTB;MD6xOVY4OiEQvF2= NULBd5JLW0GQR1XS
NCI-H716 NWPabGdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTEOnhKSzVyPUCuNVYzPjZizszN NFPvWYVUSU6JRWK=
MPP-89 NF;1VFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMU[5N|Mh|ryP MV\TRW5ITVJ?
SF126 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPBTWM2OD1yLkG3NFY{KM7:TR?= NU\hfYdmW0GQR1XS
CTB-1 M3zGeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMUezNVYh|ryP MX\TRW5ITVJ?
CA46 NE\ZSVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMUe0PFkh|ryP NYCz[HNQW0GQR1XS
NCI-H520 NXjxbIhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvFTWM2OD1yLkG3O|MzKM7:TR?= NIXhOWdUSU6JRWK=
CAL-85-1 M3nm[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnTSIhqUUN3ME2wMlE4QTJ5IN88US=> MV3TRW5ITVJ?
NCI-H2342 NX7GN2RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK1TWM2OD1yLkG4OVc4KM7:TR?= NEi4fm1USU6JRWK=
697 MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\lTWM2OD1yLkG4PFcyKM7:TR?= NHPScphUSU6JRWK=
NY MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HOc2lEPTB;MD6xPVI5PyEQvF2= M3K3WnNCVkeHUh?=
T98G M{Wxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PrWWlEPTB;MD6xPVMyQCEQvF2= NHzBcFFUSU6JRWK=
NCI-H1703 NIrENVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jLOGlEPTB;MD6xPVYyPSEQvF2= Mn;hV2FPT0WU
NCI-H2087 M2S1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLBbphxUUN3ME2wMlIxPDN7IN88US=> NIm5TG5USU6JRWK=
PF-382 M{DERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMkC4O|Mh|ryP Mm\5V2FPT0WU
HCT-116 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMkGwOlkh|ryP NEXidVBUSU6JRWK=
CAKI-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfteJIxUUN3ME2wMlIyPjZ4IN88US=> MW\TRW5ITVJ?
CCF-STTG1 NFfYcZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD3TWM2OD1yLkKyOFc2KM7:TR?= M4ja[HNCVkeHUh?=
D-392MG NWK5c25sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m4TWlEPTB;MD6yN|E4PyEQvF2= M4LrN3NCVkeHUh?=
RT-112 NH;k[mhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEmyZmtKSzVyPUCuNlM4QTVizszN Mlv3V2FPT0WU
MES-SA NWXvb2g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjmVYVKUUN3ME2wMlI1OTh5IN88US=> M4naeXNCVkeHUh?=
LC-2-ad MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\JTmlEPTB;MD6yOFI3PSEQvF2= NGf3TZpUSU6JRWK=
NOS-1 NYPoWFVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMkSzOlch|ryP NHflOmpUSU6JRWK=
NALM-6 Ml7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPrOIFlUUN3ME2wMlI2PTR|IN88US=> M{XTXXNCVkeHUh?=
TE-15 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMk[wPVEh|ryP MWHTRW5ITVJ?
786-0 M4nlWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPmXZdKSzVyPUCuNlYzOjhizszN NHrNS|dUSU6JRWK=
IST-MES1 Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;T[|JKUUN3ME2wMlI3QDJ7IN88US=> MlHqV2FPT0WU
KYSE-180 NEPrNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXOdpp6UUN3ME2wMlI3QDlzIN88US=> NEnoXYhUSU6JRWK=
YT MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjpeWc2UUN3ME2wMlI3QTd2IN88US=> NWrjc2JEW0GQR1XS
A427 MlzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMkeyOlQh|ryP M4\ZeHNCVkeHUh?=
KYSE-450 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq4TWM2OD1yLkK3N|I6KM7:TR?= MkPIV2FPT0WU
HuH-7 NI\5VZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHyTWM2OD1yLkK3O|Y{KM7:TR?= NUHySY13W0GQR1XS
CAS-1 MkP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rtfGlEPTB;MD6yPFMxOyEQvF2= NFLVUZlUSU6JRWK=
KURAMOCHI NGO5bY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMki0NVkh|ryP NH\lbZpUSU6JRWK=
ACHN MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7OTWM2OD1yLkK5N|I{KM7:TR?= MmjXV2FPT0WU
HGC-27 M1;PXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjU[Wt7UUN3ME2wMlI6OzV|IN88US=> M1PWN3NCVkeHUh?=
A172 NVXER2t6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TnTWlEPTB;MD6yPVU4PyEQvF2= M173UnNCVkeHUh?=
SNU-449 Mn;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\pc2d{UUN3ME2wMlI6QTZ2IN88US=> NGfreWlUSU6JRWK=
SW982 NVT5R3RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH6TWM2OD1yLkK5PVc5KM7:TR?= NIDhZlhUSU6JRWK=
EFO-21 M4PnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7nTWM2OD1yLkOwOFEyKM7:TR?= M1P4e3NCVkeHUh?=
NCI-H2030 NVzTNmFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwM{GxOlQh|ryP M2r1dHNCVkeHUh?=
HT-144 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\lR|hKSzVyPUCuN|EzQCEQvF2= MmTMV2FPT0WU
MFE-280 NEK2TnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfCTWM2OD1yLkOxOFU{KM7:TR?= NIrSPWFUSU6JRWK=
SK-LU-1 NX7rWmFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwM{G0OlYh|ryP NIDHPIVUSU6JRWK=
NCI-H2052 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrYXoU5UUN3ME2wMlMyPDh2IN88US=> MWLTRW5ITVJ?
SK-HEP-1 M{Doemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvl[HNKSzVyPUCuN|M{PjhizszN M2PGXnNCVkeHUh?=
QIMR-WIL MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwM{O0NlQh|ryP NGC0WoJUSU6JRWK=
A2780 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVu0ZnduUUN3ME2wMlM1OzB2IN88US=> NXPlcnoyW0GQR1XS
ACN NYDtZY5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV36cHJ{UUN3ME2wMlM1QDd|IN88US=> NH\kXZpUSU6JRWK=
BxPC-3 NFrLVGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwM{S5PFkh|ryP MlyxV2FPT0WU
BCPAP M3LMO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGzTWM2OD1yLkO2NFAyKM7:TR?= Ml3MV2FPT0WU
HOP-62 NIjBTHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwM{[xNFYh|ryP MXLTRW5ITVJ?
SW1710 NYj2TZA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwM{[0OVUh|ryP NU\RS|RNW0GQR1XS
OPM-2 M1\6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDITWM2OD1yLkO2OFc{KM7:TR?= M2fiV3NCVkeHUh?=
DBTRG-05MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm1TWM2OD1yLkO4NFU1KM7:TR?= M2\J[XNCVkeHUh?=
SK-MEL-24 M{jJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTGfm1KSzVyPUCuN|k4QTFizszN MmT6V2FPT0WU
8305C MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\PdWlEPTB;MD6zPVc6OyEQvF2= MX;TRW5ITVJ?
OVCAR-4 NGT2W5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn6xTWM2OD1yLkSxOVg3KM7:TR?= NIrO[GxUSU6JRWK=
HLE MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTPNFBVUUN3ME2wMlQyQDZizszN NH7SNFRUSU6JRWK=
NCI-H747 NEOwN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjUUI1PUUN3ME2wMlQzOTN5IN88US=> NF;mRopUSU6JRWK=
SW780 M2Dqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HhcmlEPTB;MD60NlM1PiEQvF2= MXfTRW5ITVJ?
KYSE-150 MoH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwNEK0NVUh|ryP M1HM[nNCVkeHUh?=
H4 NEmzS2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LZb2lEPTB;MD60NlQ2OSEQvF2= MYjTRW5ITVJ?
SW1088 NYDXVohbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\YW4JKSzVyPUCuOFQ{QSEQvF2= M{HkXXNCVkeHUh?=
SF268 NUj4W5FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvBbFQ2UUN3ME2wMlQ1QDZizszN NYKxSVNtW0GQR1XS
RT4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfwNHZnUUN3ME2wMlQ2OTFzIN88US=> MnHxV2FPT0WU
NCI-H522 NEO4d5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPac|dtUUN3ME2wMlQ2OjdizszN M3\IR3NCVkeHUh?=
LCLC-97TM1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEn1b4pKSzVyPUCuOFYyQTVizszN M4XIWHNCVkeHUh?=
CAL-39 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPVWJRKSzVyPUCuOFY2OTlizszN MnuwV2FPT0WU
CAL-120 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M130[WlEPTB;MD60O|Y1OyEQvF2= MofCV2FPT0WU
ESS-1 NGXpbYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HBcWlEPTB;MD60O|gzOSEQvF2= MUDTRW5ITVJ?
KARPAS-45 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTK[5BmUUN3ME2wMlQ5QTN|IN88US=> MoDYV2FPT0WU
DU-4475 M2LydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwNEm1NVEh|ryP M2m3SXNCVkeHUh?=
VMRC-RCZ MnjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojiTWM2OD1yLkS5PVA1KM7:TR?= M1qyNXNCVkeHUh?=
HOS M2HyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjJdFlKSzVyPUCuOVA{PjVizszN NYDWSJU1W0GQR1XS
MOLT-16 MkK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD6[HFKSzVyPUCuOVE5ODhizszN NV;qN|RDW0GQR1XS
RPMI-6666 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwNUKxN|Uh|ryP NEnzcVdUSU6JRWK=
K052 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml61TWM2OD1yLkWyNVQh|ryP MUTTRW5ITVJ?
EHEB M1fMNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwNUKxPFIh|ryP Mk\mV2FPT0WU
MFH-ino NWnIZ2h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwNUKzOVEh|ryP NGe1R2ZUSU6JRWK=
A4-Fuk M3K0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfDdIFXUUN3ME2wMlUzPTJ6IN88US=> NVy2XJdTW0GQR1XS
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KM-H2 NIezc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwMEGwPUDPxE1? MkXmV2FPT0WU
MC-IXC NHLGPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3JTWM2OD1{LkCyNlc{KM7:TR?= NYrsWmFxW0GQR1XS
COLO-678 M2rrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDEVYhVUUN3ME2yMlA1OjB5IN88US=> MWDTRW5ITVJ?
MEL-JUSO NIe2b4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJwMEe4OVEh|ryP M37m[HNCVkeHUh?=
HCC38 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJwMEi0N|Mh|ryP M4TucnNCVkeHUh?=
UACC-62 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrwVWhFUUN3ME2yMlA5QDV3IN88US=> Mof0V2FPT0WU
OAW-42 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj2dog{UUN3ME2yMlA6PzFzIN88US=> NEHIdVdUSU6JRWK=
LB996-RCC M1zNUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTJwMUO4NVch|ryP NFnZSFhUSU6JRWK=
COR-L105 MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJwMU[zO|Mh|ryP NXexXoczW0GQR1XS
RCC10RGB Mmm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvyTWM2OD1{LkG4OVc3KM7:TR?= Ml3TV2FPT0WU
A431 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJwMUmwNVkh|ryP Ml\tV2FPT0WU
NCI-H292 NUXJVW1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrWRWhmUUN3ME2yMlI{QTVzIN88US=> M4PHUnNCVkeHUh?=
SK-UT-1 NFPzWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjTNlVWUUN3ME2yMlM{OTh2IN88US=> NVHLdotmW0GQR1XS
PANC-08-13 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\BTWM2OD1{LkOzNlM2KM7:TR?= MnLlV2FPT0WU
ST486 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYj0VoV6UUN3ME2yMlQyODR6IN88US=> MV;TRW5ITVJ?
SJSA-1 NXO4XmE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzSRZA5UUN3ME2yMlQyOjdzIN88US=> M1:3Z3NCVkeHUh?=
RKO NWS3N49MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHGTHB5UUN3ME2yMlQzODJ7IN88US=> NX;ueI5RW0GQR1XS
NCI-H1793 NIf2XmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zxe2lEPTB;Mj60OFAzQSEQvF2= MVjTRW5ITVJ?
639-V NEmweJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vtemlEPTB;Mj60OVM5OiEQvF2= NE\HWItUSU6JRWK=
ES3 NUPvU|hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XjSmlEPTB;Mj60PVc{PyEQvF2= NH6y[FZUSU6JRWK=
NCI-H1792 M1ntcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJwNU[4NlYh|ryP MYfTRW5ITVJ?
NCI-H1651 NWfufXY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJwNUiyNUDPxE1? MVvTRW5ITVJ?
SN12C Mn3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TDUmlEPTB;Mj61PFQ5PyEQvF2= MX;TRW5ITVJ?
COLO-679 NUfYWFlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVKxZm5zUUN3ME2yMlU5PjB3IN88US=> M2nzcXNCVkeHUh?=
U-118-MG NF[5fHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfZ[4hKSzVyPUKuOVg5PzJizszN MU\TRW5ITVJ?
Ramos-2G6-4C10 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETsdW1KSzVyPUKuOlQ5ODdizszN MVPTRW5ITVJ?
HCT-15 M2q2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTWTWM2OD1{Lk[4O|kzKM7:TR?= NXLubWE1W0GQR1XS
MDA-MB-157 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDNUmdKSzVyPUKuO|A4PDdizszN MWLTRW5ITVJ?
K5 M3H4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJwN{G4OFUh|ryP M1OweHNCVkeHUh?=
MKN45 NEH1c49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmryTWM2OD1{LkezN|Y3KM7:TR?= NGq2dHpUSU6JRWK=
DMS-273 MknkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXyyPZVzUUN3ME2yMlc2PjN{IN88US=> MmnqV2FPT0WU
C8166 M1yzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zXOGlEPTB;Mj63PFUyOyEQvF2= NWD5UZI2W0GQR1XS
Calu-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TvNmlEPTB;Mj63PFk3QSEQvF2= NWq5eGVUW0GQR1XS
SNB75 MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTZO2hKSzVyPUKuPFg2OzVizszN M1r0S3NCVkeHUh?=
BFTC-905 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrrc4NKSzVyPUKuPVAyQTFizszN MlXBV2FPT0WU
C-4-II NEe4emJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJwOUGzOVMh|ryP MmHwV2FPT0WU
MS-1 M33Gb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHwTWM2OD1{Lkm2O|Y6KM7:TR?= M1[5NnNCVkeHUh?=
A375 Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTNwMEixPFQh|ryP MU\TRW5ITVJ?
KYSE-70 NGjW[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjlO25KSzVyPUOuNFg5QDJizszN MUjTRW5ITVJ?
KYSE-510 NHrt[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX0TWM2OD1|LkGwPVk2KM7:TR?= MXjTRW5ITVJ?
LN-405 NW[1SHhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zBNmlEPTB;Mz6xN|UyQCEQvF2= M17KSHNCVkeHUh?=
BOKU NGXTbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHYNmhmUUN3ME2zMlE1OjV4IN88US=> M1HMU3NCVkeHUh?=
TE-10 MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fYRmlEPTB;Mz6xO|M3OiEQvF2= MULTRW5ITVJ?
MKN1 NXfIdYdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHBVm01UUN3ME2zMlE5PDh|IN88US=> NVjPXVhrW0GQR1XS
M059J M3\3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTNwMkCxO|Mh|ryP NXfo[mVCW0GQR1XS
GOTO MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX2UGFKSzVyPUOuNlIxOzlizszN MmjzV2FPT0WU
DK-MG MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\ERYRoUUN3ME2zMlI2QTd4IN88US=> MWXTRW5ITVJ?
NCI-H727 NH[0XmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTNwMk[1PEDPxE1? MkOwV2FPT0WU
NB12 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[2Zm9MUUN3ME2zMlM{OjJ2IN88US=> Ml7vV2FPT0WU
DOK NXXjNWN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofyTWM2OD1|LkO2NVg3KM7:TR?= M3;YUnNCVkeHUh?=
KYSE-410 NIm5XXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2zTWM2OD1|LkO2Nlg4KM7:TR?= NYHtS5BQW0GQR1XS
AM-38 NXv2XmljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nqcGlEPTB;Mz6zPFA2OSEQvF2= M3X1[nNCVkeHUh?=
GR-ST NVOycXZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNwNEW3N|Ih|ryP M4LUbXNCVkeHUh?=
D-247MG M1LF[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz3TWM2OD1|LkS4NlY{KM7:TR?= NHfJWYVUSU6JRWK=
TE-8 MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\hb2lEPTB;Mz60PVM{OyEQvF2= MoXrV2FPT0WU
LS-411N NXm5cpd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYS3ZVFVUUN3ME2zMlQ6Pjl{IN88US=> NYnTSHh6W0GQR1XS
SK-MES-1 M3P1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[xTWM2OD1|LkW2OFM{KM7:TR?= NYTBcFRoW0GQR1XS
SF295 NG[xXW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTNwNkG1OVIh|ryP M2LxU3NCVkeHUh?=
SK-MEL-30 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTNwNkW5NlEh|ryP NELLcFZUSU6JRWK=
LB2241-RCC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFmwXWpKSzVyPUOuOlYzPiEQvF2= NGPIS5lUSU6JRWK=
PC-14 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j0[GlEPTB;Mz62OlQ{PyEQvF2= MWjTRW5ITVJ?
EW-7 NYDmVHJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfobZNTUUN3ME2zMlY4Pjl|IN88US=> M4j0T3NCVkeHUh?=
NMC-G1 NXj2TXdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\p[HlKSzVyPUOuO|E5OzdizszN MYfTRW5ITVJ?
TE-441-T NGX1dJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPJdnpKSzVyPUOuO|MxOjhizszN MXrTRW5ITVJ?
NCI-H1618 M2D0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknRTWM2OD1|LkixPFc2KM7:TR?= MnftV2FPT0WU
PANC-03-27 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\ydHBKSzVyPUOuPFE6OTZizszN MonVV2FPT0WU
NCI-H2228 M3zVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfnTWM2OD1|LkizNVI3KM7:TR?= MYjTRW5ITVJ?
CAPAN-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvRWGdNUUN3ME2zMlg4ODB7IN88US=> NV3IepJtW0GQR1XS
KLE MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDYOXplUUN3ME2zMlkxPjdizszN M4TGNnNCVkeHUh?=
Becker M4fxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPYcHdEUUN3ME2zMlkzQDR7IN88US=> NGi1NnZUSU6JRWK=
SK-PN-DW MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzZTWM2OD12LkC3PVc1KM7:TR?= M3LTe3NCVkeHUh?=
Hs-578-T MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITOZoJKSzVyPUSuNFg{ODZizszN MWXTRW5ITVJ?
RS4-11 NIOzR4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTRwMUGyOVUh|ryP NF6zXFdUSU6JRWK=
D-502MG NXzMXlNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTRwMU[5PVch|ryP MWPTRW5ITVJ?
GI-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LhcmlEPTB;ND6yPFI6QSEQvF2= NX[wWJozW0GQR1XS
NCI-H209 M{XXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvaTWM2OD12LkOzO|gh|ryP M3TRNnNCVkeHUh?=
SK-OV-3 M3LSO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTRwNEixOFkh|ryP M3zqXHNCVkeHUh?=
LOUCY NHHnSXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7CNZc1UUN3ME20MlQ5PDN{IN88US=> M1;ZOXNCVkeHUh?=
NCI-H69 MoD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTRwNUG3PVMh|ryP MYrTRW5ITVJ?
SCC-9 M2\4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonITWM2OD12LkWzNVczKM7:TR?= Mk\jV2FPT0WU
NCI-H526 NVXpWoZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr4TWM2OD12LkW5Nlk{KM7:TR?= M2\jOHNCVkeHUh?=
NCI-H2170 NVLYbHQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfye2dKSzVyPUSuOlY4PzFizszN MkTDV2FPT0WU
SR NGLhSVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTRwN{CwOFgh|ryP MWDTRW5ITVJ?
CMK MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr3TWM2OD12LkeyNVAyKM7:TR?= MlvRV2FPT0WU
COLO-829 NFrSelVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LqV2lEPTB;ND63O|A1OyEQvF2= NFzON29USU6JRWK=
HuO-3N1 NVXIPI9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTRwOEOyPFEh|ryP MYHTRW5ITVJ?
5637 NETwSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\Nco1EUUN3ME20MlkxPDh5IN88US=> NHXIdoNUSU6JRWK=
A253 Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P6OGlEPTB;ND65O|cxQCEQvF2= NYX6ZW9CW0GQR1XS
NB10 NIf5dGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPxboZKSzVyPUWuNFc1QTdizszN MmjBV2FPT0WU
SF539 MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXziXG54UUN3ME21MlA6QTV7IN88US=> NFq5OGJUSU6JRWK=
HAL-01 Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[wRWFKSzVyPUWuNVQ3PDVizszN Mne4V2FPT0WU
MHH-ES-1 NGrTOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTVwMU[5NlUh|ryP NUPHeGRnW0GQR1XS
DEL M336bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLu[HQxUUN3ME21MlI4PTh{IN88US=> M4K5dXNCVkeHUh?=
NCI-H1299 M1LwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjkWplGUUN3ME21MlM2ODB5IN88US=> M2jZWHNCVkeHUh?=
ChaGo-K-1 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLRfVVVUUN3ME21MlM2OTB5IN88US=> M3v0NHNCVkeHUh?=
HMV-II MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rQUmlEPTB;NT6zPVQ{KM7:TR?= NF\FPI1USU6JRWK=
NB69 NGn2ZlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjYTWM2OD13LkO5OlMyKM7:TR?= MUDTRW5ITVJ?
NCI-H1882 M3OzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnl[YFKSzVyPUWuOFM{PjRizszN NVH1OYxDW0GQR1XS
SNU-475 NH7CU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTiUHp3UUN3ME21MlQ4OTdzIN88US=> MUDTRW5ITVJ?
RXF393 Mn;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDzO5NKSzVyPUWuOFg1QTRizszN MULTRW5ITVJ?
CAL-51 M1eyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUntZW5yUUN3ME21MlYzQDV|IN88US=> M1T3[XNCVkeHUh?=
SW1573 NITCOIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXtRppKSzVyPUWuOlM2OzRizszN MUPTRW5ITVJ?
GCT NUPCboh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIGzb21KSzVyPUWuO|U6OjlizszN MWLTRW5ITVJ?
COR-L88 NGLobVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTVwN{[4OFYh|ryP MXTTRW5ITVJ?
MDA-MB-134-VI MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\rPGlEPTB;NT64O|U{PiEQvF2= NELzRlhUSU6JRWK=
NB5 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j4VGlEPTB;NT65NlQ1KM7:TR?= NWDKW25lW0GQR1XS
GMS-10 NIjMZm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVqwVppjUUN3ME21Mlk3QDZzIN88US=> M4XYcHNCVkeHUh?=
CHP-212 M1XVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3iWWs6UUN3ME22MlQ5OjZ5IN88US=> NYO4fXZCW0GQR1XS
TE-11 NFfPT3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn2TWM2OD14LkW1NVgzKM7:TR?= NGr5V3FUSU6JRWK=
SW962 M3THU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPFV4dmUUN3ME22MlY2Pzd2IN88US=> MnHoV2FPT0WU
MZ2-MEL NV3sXFdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\US2lEPTB;Nj64NlAyOSEQvF2= NIXMb3BUSU6JRWK=
C-33-A NVrte2E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;xNWlEPTB;Nj65NVY5QCEQvF2= NGL0T45USU6JRWK=
IGR-1 M4XHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXTc4RKSzVyPU[uPVc5OjZizszN MlG0V2FPT0WU
MOLT-4 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoS3TWM2OD15LkG1OFA3KM7:TR?= MYfTRW5ITVJ?
NCI-H1650 MnzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTdwMkewOFYh|ryP MkLoV2FPT0WU
AsPC-1 NH;tO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LoOWlEPTB;Nz6yPFYxPSEQvF2= M{L1bXNCVkeHUh?=
SNU-C2B NVzYUZdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlqwTWM2OD15LkK5OVcyKM7:TR?= NW\l[3NFW0GQR1XS
MKN7 MojNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnzenhQUUN3ME23MlM4OjN3IN88US=> MlLKV2FPT0WU
SW620 NWHyboRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PGfWlEPTB;Nz6zPFIxPSEQvF2= M1POTnNCVkeHUh?=
SK-MEL-28 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTJTWM2OD15LkSwO|k5KM7:TR?= NFTjTlVUSU6JRWK=
TE-6 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L6SmlEPTB;Nz60OFkxQCEQvF2= NHHuTVVUSU6JRWK=
D-263MG NFLUOIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXMOVBDUUN3ME23MlQ2PzZ{IN88US=> Ml;EV2FPT0WU
NCI-H1355 M3TVe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIj1XIdKSzVyPUeuO|cxOjlizszN NF3uXJdUSU6JRWK=
DSH1 M3fzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTdwN{m3OlIh|ryP M1fG[XNCVkeHUh?=
NCI-H460 NEfWTnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRThwMEC2PVQh|ryP M2fuNnNCVkeHUh?=
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NCI-H1993 NYKxN4VJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXyzbG9FUUN3ME2xNE42Pjl|IN88US=> NEnEbIdUSU6JRWK=
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CESS M3XLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX25NoljUUN3ME2xN{46PDh7IN88US=> NYr5TotkW0GQR1XS
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IGROV-1 MlTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW0VGpUUUN3ME2xOU4zOzF5IN88US=> MU\TRW5ITVJ?
NCI-H1648 NVy0R5I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF3LkWzNFUh|ryP NFrObGZUSU6JRWK=
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U251 M2rzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJ2LkC2Olgh|ryP MkjjV2FPT0WU
LoVo NXLHeJJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJ2LkmyPFIh|ryP NYHrdlJ2W0GQR1XS
GCIY M1PTUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHtbHFXUUN3ME2yOU4zQDd5IN88US=> MYnTRW5ITVJ?
NUGC-3 NHzW[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILx[IdKSzVyPUK1MlM{OTZizszN M2\UVnNCVkeHUh?=
LNCaP-Clone-FGC NIfEb3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn2WpFKSzVyPUK1MlM1QThizszN NHjsbY1USU6JRWK=
PA-1 MmDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJ3Lk[4N|Mh|ryP MojYV2FPT0WU
OE33 M{fVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TUPWlEPTB;MkWuOlg2OyEQvF2= NEfJTY5USU6JRWK=
HT-29 M2fiXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPETWM2OD1{NT63PFc6KM7:TR?= NGfSR4JUSU6JRWK=
RCM-1 NVPOU4M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M335dWlEPTB;MkWuPVY2PiEQvF2= MV;TRW5ITVJ?
NCI-H1522 Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HJOmlEPTB;MkWuPVkyOSEQvF2= M2fPenNCVkeHUh?=
LB373-MEL-D MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTNTWM2OD1{Nj6xO|A5KM7:TR?= MWfTRW5ITVJ?
NCI-H1436 MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPVXYNKSzVyPUK2MlI4OzhizszN MVnTRW5ITVJ?
COLO-824 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\xdW9KSzVyPUK2MlQxODJizszN NH\CVlNUSU6JRWK=
CP50-MEL-B M4\ZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3G[HlKSzVyPUK2MlU3PzVizszN MV7TRW5ITVJ?
EGI-1 M4PmZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ5LkK2PVgh|ryP MYDTRW5ITVJ?
LAN-6 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojiTWM2OD1{Nz6zOVk5KM7:TR?= M3vpdnNCVkeHUh?=
GAK NEPWZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTJ5LkSyNlUh|ryP MXzTRW5ITVJ?
MDA-MB-175-VII NVrTSHAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEC2W4tKSzVyPUK3MlUxPTNizszN MVvTRW5ITVJ?
JVM-2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrFUZU2UUN3ME2yO{43PjJ{IN88US=> M2XMeXNCVkeHUh?=
UACC-257 NU\s[pdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEWzNGpKSzVyPUK3MlY5PzhizszN Mlz1V2FPT0WU
SW1783 NVnxfWRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTQTWM2OD1{Nz63O|g{KM7:TR?= NHzxPZNUSU6JRWK=
HT-3 NFLxWINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLXTItvUUN3ME2yPE4zOTZ4IN88US=> MnH6V2FPT0WU
RL NGe4dIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfjTWM2OD1{OD61PVEyKM7:TR?= MnT4V2FPT0WU
TK10 NFPSdGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{THOWlEPTB;MkiuOlU{PSEQvF2= MojoV2FPT0WU
HT55 NXPKWnV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG2blZzUUN3ME2yPU4xPTZ3IN88US=> M3vUXHNCVkeHUh?=
BT-20 NGrFc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PUUmlEPTB;MkmuNFU5PiEQvF2= M1\INnNCVkeHUh?=
TGBC24TKB MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T0PGlEPTB;MkmuNVg{OSEQvF2= NFv3d5RUSU6JRWK=
HSC-2 NXizfG5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ7LkOwNFEh|ryP Mk\TV2FPT0WU
COLO-205 NHnTd2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS5UHFnUUN3ME2yPU4{QTR2IN88US=> MkjKV2FPT0WU
GT3TKB NGfVXpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO0ZWxKSzVyPUK5MlY5PzdizszN MYDTRW5ITVJ?
T47D M2nkUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjrPZRKSzVyPUK5Mlg2QDJizszN M1LnNHNCVkeHUh?=
OMC-1 NVfvPHY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTNyLkG5NVkh|ryP M4jPSXNCVkeHUh?=
PFSK-1 NEHKOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17udmlEPTB;M{GuNlY2QSEQvF2= NX3QS|R1W0GQR1XS
JEG-3 NGfR[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvLTWM2OD1|MT6zOVYyKM7:TR?= MWrTRW5ITVJ?
RD NWfPcIlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnD[5lKSzVyPUOxMlUyOTVizszN NVm3NoZxW0GQR1XS
NCI-H64 M1f0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN{LkSxO|kh|ryP MmfpV2FPT0WU
DMS-114 M1rhc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS0ZXNKSzVyPUOyMlQyQDJizszN M{HOcnNCVkeHUh?=
NCI-H661 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO3e5hKSzVyPUOyMlY2ODFizszN NWPWZlhsW0GQR1XS
CAL-148 NF\vbJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS1eJhKSzVyPUOyMlY3PjVizszN MXnTRW5ITVJ?
HuP-T3 NEnjR5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zmWmlEPTB;M{KuPVM{QCEQvF2= NFPWRmNUSU6JRWK=
ES4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT0UmVKSzVyPUOzMlE4ODVizszN MYrTRW5ITVJ?
Ca9-22 NF63U45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTN|LkS2NFEh|ryP NIn2UXdUSU6JRWK=
LP-1 NFz3Uo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzmZ3ZoUUN3ME2zOE4xQSEQvF2= MkDwV2FPT0WU
AU565 MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN2LkWwOlkh|ryP MnPoV2FPT0WU
MDA-MB-453 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTN3LkG0NlYh|ryP MUnTRW5ITVJ?
SNU-C1 NGfQOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLySFRKSzVyPUO1MlE4OSEQvF2= NHnQWVZUSU6JRWK=
SW13 M1nCOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTN3LkSwO|Yh|ryP NXHjcoZHW0GQR1XS
NCI-H2122 M{\rN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn74TWM2OD1|NT61OVk5KM7:TR?= Mn7VV2FPT0WU
NCI-H1395 NGrpeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn6[4dQUUN3ME2zOU43PjlzIN88US=> MUfTRW5ITVJ?
J-RT3-T3-5 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTN4LkCyPVQh|ryP M4HzOnNCVkeHUh?=
COR-L279 Mn31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTN4LkG5PFEh|ryP M13wUnNCVkeHUh?=
ATN-1 MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXucGhKSzVyPUO2Mlg2OTZizszN MVXTRW5ITVJ?
HCC2998 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTN4Lki1O|Eh|ryP NVS1dHhZW0GQR1XS
UM-UC-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fMTWlEPTB;M{[uPFY4PSEQvF2= MoL0V2FPT0WU
DV-90 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTN4LkmwOlch|ryP M3KwNXNCVkeHUh?=
ES8 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTN4LkmzNVgh|ryP NUjJPJlqW0GQR1XS
YAPC MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTN4Lkm2OVQh|ryP NXmzdHBpW0GQR1XS
HCC1599 M2fUXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTN5LkG2NVgh|ryP MlzmV2FPT0WU
UMC-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\GNlhKSzVyPUO3MlI2ODNizszN MlS5V2FPT0WU
THP-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPMPGlKSzVyPUO3MlI5PjhizszN MlzPV2FPT0WU
OCUB-M M4fnXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFniNVJKSzVyPUO3MlI5QTFizszN NU\w[FZuW0GQR1XS
NCI-H1693 NF7JfW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTN5LkOyN|Mh|ryP NGrzeJhUSU6JRWK=
NCI-H345 NGfmR4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG0TWM2OD1|Nz6zOlI1KM7:TR?= NWrLflU2W0GQR1XS
COLO-800 NYS4TWtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTN5LkW2O{DPxE1? NUfQTXgyW0GQR1XS
COLO-320-HSR MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK5SHFiUUN3ME2zPE4{PDl{IN88US=> NXrrT49GW0GQR1XS
NCI-H596 NEHSXJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\rSlJKSzVyPUO4MlQ1QDlizszN MY\TRW5ITVJ?
NCI-H187 NYHFN411T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlraTWM2OD1|OD63N|Q1KM7:TR?= MXzTRW5ITVJ?
ECC4 NFXqcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvlWIxKSzVyPUO5MlA5OTRizszN MkjvV2FPT0WU
KP-4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LuU2lEPTB;M{muNVI{PSEQvF2= Mlf3V2FPT0WU
NCI-H2227 M1i4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHxTWM2OD1|OT6zPVQ6KM7:TR?= M2POZXNCVkeHUh?=
22RV1 NXjwVHQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTN7LkizPVgh|ryP NULVcYJKW0GQR1XS
SAS NG\qflFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjnTWM2OD12MD6wPVYh|ryP MWnTRW5ITVJ?
PANC-10-05 NYTCeJNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTRyLkG4Nlgh|ryP NWi0U5RYW0GQR1XS
MDA-MB-468 NGTze|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nBR2lEPTB;NECuOVM1PiEQvF2= NXPJbVBPW0GQR1XS
RPMI-7951 NIXRcphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHIUIVKSzVyPUSxMlIxPzVizszN M3vINXNCVkeHUh?=
BB49-HNC NFy1SIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTRzLkKxO|kh|ryP NHzmSnlUSU6JRWK=
23132-87 MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTRzLkK3N|Ih|ryP M3PHZnNCVkeHUh?=
HCC1569 NXHI[Xo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\UTWM2OD12MT6yPFg2KM7:TR?= Ml64V2FPT0WU
CP66-MEL NVLIbolyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LHTGlEPTB;NEKuNVg5PiEQvF2= M3j0TnNCVkeHUh?=
K-562 M2jvbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jpbWlEPTB;NEKuNlg2PCEQvF2= NFXNUlhUSU6JRWK=
OCI-AML2 NF\kTFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfJcXBNUUN3ME20Nk45QTd2IN88US=> MmTyV2FPT0WU
SW756 NETVVI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTR|LkCzPFgh|ryP NWXudo14W0GQR1XS
M14 M3TVbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR|LkOxPFkh|ryP NEXhSZpUSU6JRWK=
NCI-H1623 M3:0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTR|LkS2OEDPxE1? MlP2V2FPT0WU
KNS-81-FD M2mzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fSSmlEPTB;NEOuO|YzKM7:TR?= NXPteWVYW0GQR1XS
TGBC1TKB NY\POIFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWW3V5JVUUN3ME20N{46ODl7IN88US=> M4S4SnNCVkeHUh?=
RERF-LC-MS M2O2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTR|LkmyPFEh|ryP MU\TRW5ITVJ?
PC-3 NW\WZWFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3PT5NKSzVyPUS0MlQ{PDdizszN Mkm4V2FPT0WU
HuP-T4 NXj4ZZQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvrT4FPUUN3ME20OE41PDd2IN88US=> NYT1fW5SW0GQR1XS
NCI-H510A MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HHdWlEPTB;NESuO|A5KM7:TR?= NHLTZmFUSU6JRWK=
LB2518-MEL NHXvdJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTR2Lke5N|ch|ryP MkDHV2FPT0WU
TE-5 NVnIV|EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonPTWM2OD12NT65OVgyKM7:TR?= MU\TRW5ITVJ?
EW-24 M1fpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD3VXZEUUN3ME20Ok4yPzJ|IN88US=> NE\sZlRUSU6JRWK=
LB647-SCLC NFzBc2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTR4LkKxOVUh|ryP Mn\SV2FPT0WU
NCI-H524 MmW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTR4LkexPFUh|ryP MoLzV2FPT0WU
EW-11 NWXYTotVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XTc2lEPTB;NE[uPVM4OyEQvF2= NE\5O|RUSU6JRWK=
KALS-1 M1XGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofTTWM2OD12Nz6yNFY3KM7:TR?= NXy1Z2FEW0GQR1XS
BT-474 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTR5LkSyNVYh|ryP M2e5OHNCVkeHUh?=
SK-N-AS NIf1PFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTR5Lki4PEDPxE1? M{PxdXNCVkeHUh?=
HCC2157 MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTR6LkC3OkDPxE1? MUjTRW5ITVJ?
HCC1954 MnSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j2O2lEPTB;NEiuNVcxPCEQvF2= MVXTRW5ITVJ?
FADU MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnzZ3k1UUN3ME20PE4{ODNzIN88US=> NWPXbJNPW0GQR1XS
S-117 M{Hj[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPiNVlKSzVyPUS4MlM5OTVizszN Mo\zV2FPT0WU
LS-1034 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj0TWM2OD12OD63NFY4KM7:TR?= NYn5XVVCW0GQR1XS
CAMA-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWG1V5FuUUN3ME20PU42PTR|IN88US=> M17UUXNCVkeHUh?=
LU-134-A MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnYTWM2OD12OT64NFg2KM7:TR?= NVTUd|hvW0GQR1XS
NCI-H1838 MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\qTWM2OD12OT64NFg4KM7:TR?= M3\aOnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]
臨床試験 AP24534 is currently under Phase II clinical trials in treatment with leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Peptide substrate phosphorylation assays with GST-Abl kinase domains The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.

細胞アッセイ: [2]

細胞株 Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
濃度 0-625 nM
反応時間 72 hours
実験の流れ Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat

動物実験: [1]

動物モデル Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
製剤 Dissolved in 25 mM citrate buffer, pH 2.75
投薬量 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
投与方法 Oral gavage once daily

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Ponatinib (AP24534) SDF
分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (56.33 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 3-(2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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Source Cancer Cell, 2012, 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck
Method Western blot
Cell Lines RCH-ACV cells
Concentrations 50 nM
Incubation Time 1-24 h
Results Treatment of these cells with a CSK inhibitor (BMS-599626) or a BTK inhibitor (PCI-32765) did not recapitulate the dasatinib/ponatinib phenotype.

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Source , , Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck
Method Cell Proliferation Assay
Cell Lines KatoIII cells
Concentrations 0-0.5 nM
Incubation Time
Results Each of the inhibitors demonstrated a statistically significant lower IC50 in FGFR2-amplified KatoIII cells compared to non-FGFR2-amplified AGS cells at all concentrations tested.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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