Ponatinib (AP24534)

Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。

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Ponatinib (AP24534) 化学構造
分子量: 532.56

高品質保証

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MSDS

製品説明

  • Compare Bcr-Abl Inhibitors
    Bcr-Abl製品生物活性の比較
  • 研究分野
  • Ponatinib (AP24534)のメカニズム

製品の説明

生物活性

製品説明 Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。
ターゲット Abl PDGFRα VEGFR2 FGFR1 Src
IC50 0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM [1]
In vitro試験 AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell NYTYbHpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;jUmRKSzVyPUCuNFAxODByMEO1PUDPxE1? Ml33V2FPT0WU
MV-4-11 NVu3d3JiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrTS|BKSzVyPUCuNFAxODl3NjFOwG0> MXLTRW5ITVJ?
MEG-01 M4fmUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP3VJByUUN3ME2wMlAxODF{ODFOwG0> MX\TRW5ITVJ?
LAMA-84 NV;RNFB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XnXmlEPTB;MD6wNFAyPjVizszN NIXIUJpUSU6JRWK=
CGTH-W-1 M{G5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMECxOlkh|ryP NET2NJBUSU6JRWK=
KASUMI-1 MnfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPzNHRtUUN3ME2wMlAxOjF5IN88US=> NFTyT3NUSU6JRWK=
BE-13 NVjCUVBnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3mwT2lEPTB;MD6wNFI2QSEQvF2= M{GxdHNCVkeHUh?=
CTV-1 NWPMfZh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXmZWVKSzVyPUCuNFA2OjFizszN MVzTRW5ITVJ?
NKM-1 Ml7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEC2OVUh|ryP MYLTRW5ITVJ?
MONO-MAC-6 Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEC4N|ch|ryP NVH4U2pkW0GQR1XS
A204 NVj5XXo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\VTWM2OD1yLkCxNlE5KM7:TR?= NGTNcHZUSU6JRWK=
GDM-1 MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;VbIxKSzVyPUCuNFE5OzNizszN M4r2VnNCVkeHUh?=
AN3-CA M2XVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe2Noh6UUN3ME2wMlAyQDd|IN88US=> NIfqT4ZUSU6JRWK=
BL-70 NULPdGNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDEfGJxUUN3ME2wMlAzOTl7IN88US=> NIfhSWNUSU6JRWK=
Daudi MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2T1cWlEPTB;MD6wNlU{PyEQvF2= Ml;jV2FPT0WU
KU812 MnLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnuzTWM2OD1yLkCyPFQ5KM7:TR?= NVjUN|U6W0GQR1XS
KG-1 MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[zNI9iUUN3ME2wMlA{Ojl2IN88US=> Mnn0V2FPT0WU
DOHH-2 NXTzSoRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;oNJlsUUN3ME2wMlA1QDB|IN88US=> NU\QcoNvW0GQR1XS
HuO9 MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjYSI9EUUN3ME2wMlA2PDR6IN88US=> MXzTRW5ITVJ?
EB2 NFHYU|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUThW29kUUN3ME2wMlA2PTd4IN88US=> M{TR[HNCVkeHUh?=
G-402 MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vVOGlEPTB;MD6wOlM1OSEQvF2= NYe4bVlrW0GQR1XS
SU-DHL-1 NXPG[pB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzRfpZKSzVyPUCuNFY{PzlizszN NYTTU41nW0GQR1XS
NCI-H719 M1\sdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuxTWM2OD1yLkC3PFg5KM7:TR?= NH7lTnNUSU6JRWK=
MLMA NGLndGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rmemlEPTB;MD6wPVA3KM7:TR?= M3m5XHNCVkeHUh?=
KM12 NF3FW3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEm3N|ch|ryP MXHTRW5ITVJ?
SUP-T1 NEHtbodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTrcIk{UUN3ME2wMlA6QTh{IN88US=> NHvGdY1USU6JRWK=
MZ1-PC M{LScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLDUnllUUN3ME2wMlEyOzN4IN88US=> NWPaTldEW0GQR1XS
MFE-296 NF3UWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnDcHRKSzVyPUCuNVE5OzlizszN NYe2cGV6W0GQR1XS
ALL-PO M2jlVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMUK0OFMh|ryP NUfwSZFSW0GQR1XS
GB-1 Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfL[pJKSzVyPUCuNVI2OTJizszN M2nDfXNCVkeHUh?=
SIG-M5 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMUOzO{DPxE1? NF6w[WdUSU6JRWK=
P30-OHK M{XsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i3O2lEPTB;MD6xOVY4OiEQvF2= MkTsV2FPT0WU
NCI-H716 M4iwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMU[yOlYh|ryP NFuxSW5USU6JRWK=
MPP-89 NHzwdmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rGNmlEPTB;MD6xOlk{OyEQvF2= NYexRopLW0GQR1XS
SF126 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HJPWlEPTB;MD6xO|A3OyEQvF2= MUfTRW5ITVJ?
CTB-1 M1nBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf1ZYNKSzVyPUCuNVc{OTZizszN NILFSlFUSU6JRWK=
CA46 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvqTWM2OD1yLkG3OFg6KM7:TR?= MlLEV2FPT0WU
NCI-H520 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3ZO4lKSzVyPUCuNVc4OzJizszN M2W0c3NCVkeHUh?=
CAL-85-1 NGPtfIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnyTWM2OD1yLkG3PVI4KM7:TR?= MlHlV2FPT0WU
NCI-H2342 M1POfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PLS2lEPTB;MD6xPFU4PyEQvF2= MX3TRW5ITVJ?
697 M1rCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP6TWM2OD1yLkG4PFcyKM7:TR?= NXL6fYFOW0GQR1XS
NY NFPDUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jUSWlEPTB;MD6xPVI5PyEQvF2= NFHCSVBUSU6JRWK=
T98G MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:5TWM2OD1yLkG5N|E5KM7:TR?= NVzFTmszW0GQR1XS
NCI-H1703 NFftPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMUm2NVUh|ryP Ml[0V2FPT0WU
NCI-H2087 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13oPGlEPTB;MD6yNFQ{QSEQvF2= M3;NVHNCVkeHUh?=
PF-382 M2n0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMkC4O|Mh|ryP Mof1V2FPT0WU
HCT-116 NX7wS3FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF74dopKSzVyPUCuNlExPjlizszN NGrTdWVUSU6JRWK=
CAKI-1 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXwTWM2OD1yLkKxOlY3KM7:TR?= M{X2TXNCVkeHUh?=
CCF-STTG1 NILSZ2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljJTWM2OD1yLkKyOFc2KM7:TR?= NEfrRYRUSU6JRWK=
D-392MG MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHDTGxQUUN3ME2wMlI{OTd5IN88US=> MorWV2FPT0WU
RT-112 M4LMWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy1cYl[UUN3ME2wMlI{Pzl3IN88US=> M2HO[3NCVkeHUh?=
MES-SA MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMkSxPFch|ryP MV\TRW5ITVJ?
LC-2-ad NGe1eJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH6TWM2OD1yLkK0NlY2KM7:TR?= NFPLZpNUSU6JRWK=
NOS-1 M{O3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn2TWM2OD1yLkK0N|Y4KM7:TR?= M{C5ZnNCVkeHUh?=
NALM-6 MmLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zTV2lEPTB;MD6yOVU1OyEQvF2= MofkV2FPT0WU
TE-15 NGrQWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnGfoQ4UUN3ME2wMlI3ODlzIN88US=> NIO3R3NUSU6JRWK=
786-0 M3LwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPyTWM2OD1yLkK2NlI5KM7:TR?= MWHTRW5ITVJ?
IST-MES1 NXXCPVdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq1bVVjUUN3ME2wMlI3QDJ7IN88US=> NXiycJRQW0GQR1XS
KYSE-180 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULGco9UUUN3ME2wMlI3QDlzIN88US=> NH6wW4lUSU6JRWK=
YT MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCxeGRKSzVyPUCuNlY6PzRizszN NVXYOZFkW0GQR1XS
A427 NWDTPYRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vPSWlEPTB;MD6yO|I3PCEQvF2= MmnFV2FPT0WU
KYSE-450 NYLXd4VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn2em9qUUN3ME2wMlI4OzJ7IN88US=> MlnWV2FPT0WU
HuH-7 NXqzSXpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLyTWM2OD1yLkK3O|Y{KM7:TR?= MoThV2FPT0WU
CAS-1 NXH2NlZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n6TGlEPTB;MD6yPFMxOyEQvF2= M3;GdnNCVkeHUh?=
KURAMOCHI MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHjRY1RUUN3ME2wMlI5PDF7IN88US=> MXnTRW5ITVJ?
ACHN NWracoFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvsNVdJUUN3ME2wMlI6OzJ|IN88US=> M1[4Z3NCVkeHUh?=
HGC-27 MmPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMkmzOVMh|ryP NVr0VVNHW0GQR1XS
A172 NWj4Xpk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMkm1O|ch|ryP NHHRWmpUSU6JRWK=
SNU-449 NYHCeohvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jIcmlEPTB;MD6yPVk3PCEQvF2= M2nnZXNCVkeHUh?=
SW982 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PTcWlEPTB;MD6yPVk4QCEQvF2= NVTjNGpsW0GQR1XS
EFO-21 M{XmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jPSWlEPTB;MD6zNFQyOSEQvF2= NUXWUI9pW0GQR1XS
NCI-H2030 M{\x[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG0UYtCUUN3ME2wMlMyOTZ2IN88US=> NFv5U4hUSU6JRWK=
HT-144 NYjuWlBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D2S2lEPTB;MD6zNVI5KM7:TR?= NGPJVZpUSU6JRWK=
MFE-280 NFPC[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnseohKSzVyPUCuN|E1PTNizszN M4rRVnNCVkeHUh?=
SK-LU-1 NXnwZlJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzxTWM2OD1yLkOxOFY3KM7:TR?= MnGxV2FPT0WU
NCI-H2052 M2P3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTNSYZwUUN3ME2wMlMyPDh2IN88US=> Mn\KV2FPT0WU
SK-HEP-1 NXXifWpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwM{OzOlgh|ryP NW\oUYE2W0GQR1XS
QIMR-WIL M{H4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjJS4RKSzVyPUCuN|M1OjRizszN NH\YfYJUSU6JRWK=
A2780 NEnZfnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwM{SzNFQh|ryP M1jUZnNCVkeHUh?=
ACN Mn7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwM{S4O|Mh|ryP NIDZSZlUSU6JRWK=
BxPC-3 NELselZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;WTWM2OD1yLkO0PVg6KM7:TR?= MnKwV2FPT0WU
BCPAP NH3mc3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;iTWM2OD1yLkO2NFAyKM7:TR?= NVLTTJpPW0GQR1XS
HOP-62 NXfPdJRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfZXGdKSzVyPUCuN|YyODZizszN MX;TRW5ITVJ?
SW1710 NVi4Vo1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwM{[0OVUh|ryP MVPTRW5ITVJ?
OPM-2 M4O1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwM{[0O|Mh|ryP MoriV2FPT0WU
DBTRG-05MG M17je2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrxZ5dKSzVyPUCuN|gxPTRizszN NUfKbplDW0GQR1XS
SK-MEL-24 M4XocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzHNIRKSzVyPUCuN|k4QTFizszN M1rk[XNCVkeHUh?=
8305C MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwM{m3PVMh|ryP MoTaV2FPT0WU
OVCAR-4 NXPzUXppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r1XWlEPTB;MD60NVU5PiEQvF2= NXvXUldSW0GQR1XS
HLE MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLUcHUzUUN3ME2wMlQyQDZizszN NFf1e3NUSU6JRWK=
NCI-H747 MmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP5eVltUUN3ME2wMlQzOTN5IN88US=> MULTRW5ITVJ?
SW780 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWexTXExUUN3ME2wMlQzOzR4IN88US=> M3OxOXNCVkeHUh?=
KYSE-150 MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTsUGxvUUN3ME2wMlQzPDF3IN88US=> M1LjOXNCVkeHUh?=
H4 NFnxOYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrpb|BkUUN3ME2wMlQzPDVzIN88US=> MkmzV2FPT0WU
SW1088 NEfRd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLKV2VKSzVyPUCuOFQ{QSEQvF2= NYXVPXBUW0GQR1XS
SF268 M3zZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwNES4OkDPxE1? NGXiSmpUSU6JRWK=
RT4 M3;WT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwNEWxNVEh|ryP MnmxV2FPT0WU
NCI-H522 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwNEWyO{DPxE1? MY\TRW5ITVJ?
LCLC-97TM1 NWm1b25mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwNE[xPVUh|ryP M{nVO3NCVkeHUh?=
CAL-39 MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17qfGlEPTB;MD60OlUyQSEQvF2= NHjYb3hUSU6JRWK=
CAL-120 NHGxSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPJWVVMUUN3ME2wMlQ4PjR|IN88US=> NHXCe|dUSU6JRWK=
ESS-1 M4[5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfW[mp{UUN3ME2wMlQ4QDJzIN88US=> Ml;MV2FPT0WU
KARPAS-45 NYi3Ood5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHCOVNjUUN3ME2wMlQ5QTN|IN88US=> Mn7wV2FPT0WU
DU-4475 Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwNEm1NVEh|ryP NFrGcFBUSU6JRWK=
VMRC-RCZ MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\XPW5KSzVyPUCuOFk6ODRizszN NUniOm5jW0GQR1XS
HOS NIX2cldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M131XGlEPTB;MD61NFM3PSEQvF2= NWnDUYxyW0GQR1XS
MOLT-16 NFzHVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzBTWM2OD1yLkWxPFA5KM7:TR?= NWS2bGVTW0GQR1XS
RPMI-6666 Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjHNphKSzVyPUCuOVIyOzVizszN MWXTRW5ITVJ?
K052 MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorITWM2OD1yLkWyNVQh|ryP NV;0OpR1W0GQR1XS
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MKN28 Mnv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPITWtMUUN3ME2xMlI2PjN4IN88US=> MVzTRW5ITVJ?
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A673 NH[xXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTjTWM2OD1zLkm3OVE3KM7:TR?= MUjTRW5ITVJ?
L-428 M{Hmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfqRZB[UUN3ME2xMlk6OTd7IN88US=> MkjJV2FPT0WU
KM-H2 NFLzRYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml73TWM2OD1{LkCxNFkh|ryP NXXxN5lyW0GQR1XS
MC-IXC NYLqVZpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJwMEKyO|Mh|ryP M{L0c3NCVkeHUh?=
COLO-678 NGrENYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fw[WlEPTB;Mj6wOFIxPyEQvF2= NYjw[mQ1W0GQR1XS
MEL-JUSO M1rGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLpTWM2OD1{LkC3PFUyKM7:TR?= MX;TRW5ITVJ?
HCC38 Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrJTIlKUUN3ME2yMlA5PDN|IN88US=> NGXJb5lUSU6JRWK=
UACC-62 NU\5NnBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjteHhKSzVyPUKuNFg5PTVizszN M{HCc3NCVkeHUh?=
OAW-42 M3ns[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzsPWpKSzVyPUKuNFk4OTFizszN NUHs[I1bW0GQR1XS
LB996-RCC MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJwMUO4NVch|ryP Mk\pV2FPT0WU
COR-L105 MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvnTWM2OD1{LkG2N|c{KM7:TR?= Mlq0V2FPT0WU
RCC10RGB MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJwMUi1O|Yh|ryP MWDTRW5ITVJ?
A431 NHLpSmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJwMUmwNVkh|ryP MV\TRW5ITVJ?
NCI-H292 NGDLbXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHCbIJ[UUN3ME2yMlI{QTVzIN88US=> MlnQV2FPT0WU
SK-UT-1 NVfJOpc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnUSHpLUUN3ME2yMlM{OTh2IN88US=> MW\TRW5ITVJ?
PANC-08-13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTNU2p7UUN3ME2yMlM{OjN3IN88US=> NG\iWoNUSU6JRWK=
ST486 NX36SGlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFm4[|JKSzVyPUKuOFExPDhizszN MXzTRW5ITVJ?
SJSA-1 NFqwNm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJwNEGyO|Eh|ryP NEK5[YFUSU6JRWK=
RKO M1TvV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T5bmlEPTB;Mj60NlAzQSEQvF2= NVWzbmd3W0GQR1XS
NCI-H1793 M4f0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mne2TWM2OD1{LkS0NFI6KM7:TR?= NYDiVmQ6W0GQR1XS
639-V MnTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HZW2lEPTB;Mj60OVM5OiEQvF2= NGW0b2RUSU6JRWK=
ES3 M1PFVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Hk[mlEPTB;Mj60PVc{PyEQvF2= NWPRUIVzW0GQR1XS
NCI-H1792 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG2eVZOUUN3ME2yMlU3QDJ4IN88US=> MX3TRW5ITVJ?
NCI-H1651 MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLtTWM2OD1{LkW4NlEh|ryP NG\ydoFUSU6JRWK=
SN12C NGe3N|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fwUmlEPTB;Mj61PFQ5PyEQvF2= MUjTRW5ITVJ?
COLO-679 MlrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJwNUi2NFUh|ryP NVXUfG5GW0GQR1XS
U-118-MG NG\s[nFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTw[pZTUUN3ME2yMlU5QDd{IN88US=> NHzBRnNUSU6JRWK=
Ramos-2G6-4C10 M4fxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3PcGFKSzVyPUKuOlQ5ODdizszN M3nBT3NCVkeHUh?=
HCT-15 NXzieFhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTa[JFKSzVyPUKuOlg4QTJizszN NHjiZXNUSU6JRWK=
MDA-MB-157 NGGy[W1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXNOJdKSzVyPUKuO|A4PDdizszN M2OxSXNCVkeHUh?=
K5 NIrNXJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XCTGlEPTB;Mj63NVg1PSEQvF2= NWD6R2FWW0GQR1XS
MKN45 NW[4SXpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn5RnNKSzVyPUKuO|M{PjZizszN NVO0fIFzW0GQR1XS
DMS-273 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX4ZpJoUUN3ME2yMlc2PjN{IN88US=> NFO5eXVUSU6JRWK=
C8166 M3nkcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnUTWM2OD1{Lke4OVE{KM7:TR?= NFi4Z|FUSU6JRWK=
Calu-3 NVj2d4FiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr1dY57UUN3ME2yMlc5QTZ7IN88US=> MkPZV2FPT0WU
SNB75 Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4K2SGlEPTB;Mj64PFU{PSEQvF2= MknSV2FPT0WU
BFTC-905 NF3W[ZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7ndpRYUUN3ME2yMlkxOTlzIN88US=> M3jP[XNCVkeHUh?=
C-4-II M1XyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnyTWM2OD1{LkmxN|U{KM7:TR?= MYjTRW5ITVJ?
MS-1 MlfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\nWY9vUUN3ME2yMlk3PzZ7IN88US=> NF;aNZNUSU6JRWK=
A375 NFLL[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEW0XFhKSzVyPUOuNFgyQDRizszN Mn\xV2FPT0WU
KYSE-70 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLhTWM2OD1|LkC4PFgzKM7:TR?= M3nXfnNCVkeHUh?=
KYSE-510 M3TsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vhfGlEPTB;Mz6xNFk6PSEQvF2= M3Pl[XNCVkeHUh?=
LN-405 NH31d5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrPWWdMUUN3ME2zMlE{PTF6IN88US=> NFPKc|BUSU6JRWK=
BOKU Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n6bmlEPTB;Mz6xOFI2PiEQvF2= NX35dJlJW0GQR1XS
TE-10 M{PFSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnTTWM2OD1|LkG3N|YzKM7:TR?= NGnLNphUSU6JRWK=
MKN1 NELNdo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPPTWM2OD1|LkG4OFg{KM7:TR?= NXK2XXJ4W0GQR1XS
M059J M3nScmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W3bWlEPTB;Mz6yNFE4OyEQvF2= MUXTRW5ITVJ?
GOTO NYjBSmEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvwTWM2OD1|LkKyNFM6KM7:TR?= M2\jUHNCVkeHUh?=
DK-MG MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q3d2lEPTB;Mz6yOVk4PiEQvF2= NXPwNYV3W0GQR1XS
NCI-H727 Mn3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTNwMk[1PEDPxE1? Mk\NV2FPT0WU
NB12 NUe3eZp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTNwM{OyNlQh|ryP M4DLWnNCVkeHUh?=
DOK NUDmNVhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojuTWM2OD1|LkO2NVg3KM7:TR?= MVnTRW5ITVJ?
KYSE-410 NW\wd3BmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFO2RmlKSzVyPUOuN|YzQDdizszN Mmq4V2FPT0WU
AM-38 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnFTWM2OD1|LkO4NFUyKM7:TR?= M2nlSHNCVkeHUh?=
GR-ST NUSyW5JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTkR3J6UUN3ME2zMlQ2PzN{IN88US=> NXnrV213W0GQR1XS
D-247MG M3XsW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXBb2Q{UUN3ME2zMlQ5OjZ|IN88US=> NGS3ZopUSU6JRWK=
TE-8 NFz1fmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHi4UmVKSzVyPUOuOFk{OzNizszN NXTBc3h[W0GQR1XS
LS-411N M4i0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzxenBKSzVyPUOuOFk3QTJizszN M2D6VXNCVkeHUh?=
SK-MES-1 M2PubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHuTWM2OD1|LkW2OFM{KM7:TR?= MV7TRW5ITVJ?
SF295 NYH4PWlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTQepZqUUN3ME2zMlYyPTV{IN88US=> MXzTRW5ITVJ?
SK-MEL-30 Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnweHE1UUN3ME2zMlY2QTJzIN88US=> MmnzV2FPT0WU
LB2241-RCC NIDkZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS5[nFEUUN3ME2zMlY3OjZizszN M{PHd3NCVkeHUh?=
PC-14 NFHSZWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7XTWM2OD1|Lk[2OFM4KM7:TR?= M{D0WXNCVkeHUh?=
EW-7 M3PrcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXTTWM2OD1|Lk[3Olk{KM7:TR?= NIG1VGhUSU6JRWK=
NMC-G1 NVzMSnIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLXTWM2OD1|LkexPFM4KM7:TR?= M2X4bnNCVkeHUh?=
TE-441-T M3zDcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3XeWtKSzVyPUOuO|MxOjhizszN MV7TRW5ITVJ?
NCI-H1618 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTNwOEG4O|Uh|ryP MV;TRW5ITVJ?
PANC-03-27 NYDYe3d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3myNGlEPTB;Mz64NVkyPiEQvF2= NE[3c|dUSU6JRWK=
NCI-H2228 MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvRNHFKSzVyPUOuPFMyOjZizszN NETzbHhUSU6JRWK=
CAPAN-1 NXTRd2JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3rNndWUUN3ME2zMlg4ODB7IN88US=> M3LpUXNCVkeHUh?=
KLE NULRdnRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTiNWVtUUN3ME2zMlkxPjdizszN M3TGZ3NCVkeHUh?=
Becker Mo\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2CxVWlEPTB;Mz65Nlg1QSEQvF2= MXvTRW5ITVJ?
SK-PN-DW NWfiXnM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjQ[VhoUUN3ME20MlA4QTd2IN88US=> MYjTRW5ITVJ?
Hs-578-T MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTRwMEizNFYh|ryP NWiye5lzW0GQR1XS
RS4-11 M1n1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDPNolKSzVyPUSuNVEzPTVizszN NYnTVY53W0GQR1XS
D-502MG NF\HVYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvkemFKSzVyPUSuNVY6QTdizszN MXzTRW5ITVJ?
GI-1 M{fTeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3PTWM2OD12LkK4Nlk6KM7:TR?= MoHjV2FPT0WU
NCI-H209 M{XwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmCxTWM2OD12LkOzO|gh|ryP MmXLV2FPT0WU
SK-OV-3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmW3TWM2OD12LkS4NVQ6KM7:TR?= MkfKV2FPT0WU
LOUCY MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTRwNEi0N|Ih|ryP M1vRWXNCVkeHUh?=
NCI-H69 MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn1TWM2OD12LkWxO|k{KM7:TR?= NXPlbG1kW0GQR1XS
SCC-9 NWi2WFFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHiydZBKSzVyPUSuOVMyPzJizszN M3fwfXNCVkeHUh?=
NCI-H526 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIWxZXRKSzVyPUSuOVkzQTNizszN NIj0blBUSU6JRWK=
NCI-H2170 NXz2TXdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnMc252UUN3ME20MlY3PzdzIN88US=> NGDCR4ZUSU6JRWK=
SR MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L0ZWlEPTB;ND63NFA1QCEQvF2= NI\nZm5USU6JRWK=
CMK NVfEPVh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfkWYlTUUN3ME20MlczOTBzIN88US=> NI\qblNUSU6JRWK=
COLO-829 MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTRwN{ewOFMh|ryP MWjTRW5ITVJ?
HuO-3N1 M2nrSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHuTWM2OD12LkizNlgyKM7:TR?= M3rGdnNCVkeHUh?=
5637 NH3jS2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvlWHFKSzVyPUSuPVA1QDdizszN M1TobnNCVkeHUh?=
A253 NEO1bZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfNepV4UUN3ME20Mlk4PzB6IN88US=> NGXlN5ZUSU6JRWK=
NB10 NHztN2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33aPGlEPTB;NT6wO|Q6PyEQvF2= NVT6VllWW0GQR1XS
SF539 M3G4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfWcWVKSzVyPUWuNFk6PTlizszN MYXTRW5ITVJ?
HAL-01 NFX0V21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfV[ZNKSzVyPUWuNVQ3PDVizszN NXriOI9XW0GQR1XS
MHH-ES-1 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL6TWM2OD13LkG2PVI2KM7:TR?= M{HL[nNCVkeHUh?=
DEL NIqwWHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTVwMke1PFIh|ryP M{PEZXNCVkeHUh?=
NCI-H1299 NFjiNGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrMTWM2OD13LkO1NFA4KM7:TR?= M{S5eXNCVkeHUh?=
ChaGo-K-1 M{m5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofXTWM2OD13LkO1NVA4KM7:TR?= NUDRTZpNW0GQR1XS
HMV-II NYfX[JRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\yPWlEPTB;NT6zPVQ{KM7:TR?= M4HpcXNCVkeHUh?=
NB69 M2H1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH4TWM2OD13LkO5OlMyKM7:TR?= MWDTRW5ITVJ?
NCI-H1882 NGL3eIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r2U2lEPTB;NT60N|M3PCEQvF2= M{TMPHNCVkeHUh?=
SNU-475 NGC3ZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTVwNEexO|Eh|ryP MnznV2FPT0WU
RXF393 NXnV[HM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTTenJRUUN3ME21MlQ5PDl2IN88US=> M2nBZnNCVkeHUh?=
CAL-51 NG\ibm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTVwNkK4OVMh|ryP MV;TRW5ITVJ?
SW1573 NIrJWFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;B[m1KSzVyPUWuOlM2OzRizszN MWjTRW5ITVJ?
GCT NITMNIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHrfnJKSzVyPUWuO|U6OjlizszN MWnTRW5ITVJ?
COR-L88 M{fyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LCRmlEPTB;NT63Olg1PiEQvF2= M3W0OXNCVkeHUh?=
MDA-MB-134-VI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jKe2lEPTB;NT64O|U{PiEQvF2= M3nqR3NCVkeHUh?=
NB5 NEWwVoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm5VpBKSzVyPUWuPVI1PCEQvF2= M{\UeHNCVkeHUh?=
GMS-10 M1vUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj3clRlUUN3ME21Mlk3QDZzIN88US=> M3LsfnNCVkeHUh?=
CHP-212 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zFNmlEPTB;Nj60PFI3PyEQvF2= M3vOTHNCVkeHUh?=
TE-11 NWH4cGxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH5S2N2UUN3ME22MlU2OTh{IN88US=> M{jvT3NCVkeHUh?=
SW962 NYTGeZl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTZwNkW3O|Qh|ryP MlrUV2FPT0WU
MZ2-MEL NEW0WHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrr[ohKSzVyPU[uPFIxOTFizszN Mn3rV2FPT0WU
C-33-A MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTZTWM2OD14LkmxOlg5KM7:TR?= NI\0b45USU6JRWK=
IGR-1 M4rUe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHMNW1qUUN3ME22Mlk4QDJ4IN88US=> M2DXWHNCVkeHUh?=
MOLT-4 NEXzeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NISwfYpKSzVyPUeuNVU1ODZizszN MmW2V2FPT0WU
NCI-H1650 MoGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoKzTWM2OD15LkK3NFQ3KM7:TR?= MVjTRW5ITVJ?
AsPC-1 MoXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTdwMki2NFUh|ryP NFnIOpJUSU6JRWK=
SNU-C2B M4jOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPRWph[UUN3ME23MlI6PTdzIN88US=> M2nMfnNCVkeHUh?=
MKN7 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTRV3BKSzVyPUeuN|czOzVizszN NYjLXG1zW0GQR1XS
SW620 NXnzVYtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X0O2lEPTB;Nz6zPFIxPSEQvF2= NWn4elVIW0GQR1XS
SK-MEL-28 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL0fHZ7UUN3ME23MlQxPzl6IN88US=> NEfyPFBUSU6JRWK=
TE-6 Moj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTdwNES5NFgh|ryP MnHFV2FPT0WU
D-263MG NU\VRnk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTdwNEW3OlIh|ryP MVPTRW5ITVJ?
NCI-H1355 MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjrWXd[UUN3ME23Mlc4ODJ7IN88US=> MnzxV2FPT0WU
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NCI-H1563 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2G5fmlEPTB;OD6wO|UxQCEQvF2= M2nkS3NCVkeHUh?=
SW948 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRThwMUC3OFQh|ryP NGjTT2JUSU6JRWK=
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HT-1080 M3jxTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTtTWM2OD16LkGzNVc2KM7:TR?= MmrOV2FPT0WU
NCI-H441 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj2TWM2OD16LkG5N{DPxE1? Mmr0V2FPT0WU
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LXF-289 Ml;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;1N5hHUUN3ME24MlM2QTR|IN88US=> MkPrV2FPT0WU
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Detroit562 M2i3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRThwN{W0OVUh|ryP M3HiZnNCVkeHUh?=
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P12-ICHIKAWA M4Dt[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PPNGlEPTB;OD63PFk1KM7:TR?= M3npd3NCVkeHUh?=
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NCI-H2196 Mn3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfNZmFKSzVyPUiuPVg3ODZizszN M{LJeXNCVkeHUh?=
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NCI-N87 NHXr[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVftcYxKUUN3ME25MlQ1PzNzIN88US=> NF;SZmRUSU6JRWK=
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IPC-298 Mme0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDQb29DUUN3ME2xNU46Ozh|IN88US=> NVr6XpdZW0GQR1XS
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OVCAR-8 M4nkeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXviZ|VsUUN3ME2xNk4yOTRzIN88US=> MkPnV2FPT0WU
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BB65-RCC M2\PUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTmc4pqUUN3ME2yN{4xOzR2IN88US=> MUnTRW5ITVJ?
SiHa MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTJ|LkO5Olgh|ryP NIfn[GRUSU6JRWK=
NCI-H2081 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ2LkC2OFEh|ryP NXfJVFV4W0GQR1XS
U251 NEn4WYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV25SWpJUUN3ME2yOE4xPjZ6IN88US=> MXrTRW5ITVJ?
LoVo NUX4e3QyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJ2LkmyPFIh|ryP M1G0VHNCVkeHUh?=
GCIY MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG4TWM2OD1{NT6yPFc4KM7:TR?= NYPTNVBjW0GQR1XS
NUGC-3 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\qTWM2OD1{NT6zN|E3KM7:TR?= NWHHR2k3W0GQR1XS
LNCaP-Clone-FGC NGK3dI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHZTWM2OD1{NT6zOFk5KM7:TR?= NEewenpUSU6JRWK=
PA-1 MmTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7BTWM2OD1{NT62PFM{KM7:TR?= M3vwenNCVkeHUh?=
OE33 NWjhc2hGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fyNmlEPTB;MkWuOlg2OyEQvF2= MWfTRW5ITVJ?
HT-29 NH;EU4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnjTWM2OD1{NT63PFc6KM7:TR?= M2fWSnNCVkeHUh?=
RCM-1 NUfPSWhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;mN2lEPTB;MkWuPVY2PiEQvF2= NHrNe4JUSU6JRWK=
NCI-H1522 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\ZN3JDUUN3ME2yOU46QTFzIN88US=> NGnWW4xUSU6JRWK=
LB373-MEL-D NWDxdodUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\3UFc{UUN3ME2yOk4yPzB6IN88US=> MmrKV2FPT0WU
NCI-H1436 M1PrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTJ4LkK3N|gh|ryP NEjQe5hUSU6JRWK=
COLO-824 NV\6NnJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJ4LkSwNFIh|ryP Mmj6V2FPT0WU
CP50-MEL-B NWPYT5RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\n[4RHUUN3ME2yOk42Pjd3IN88US=> NUDBclRuW0GQR1XS
EGI-1 NVeyd|liT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37mXWlEPTB;MkeuNlY6QCEQvF2= MlOwV2FPT0WU
LAN-6 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7BTWM2OD1{Nz6zOVk5KM7:TR?= NX7KRod{W0GQR1XS
GAK NGmzWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJ5LkSyNlUh|ryP M3Pl[nNCVkeHUh?=
MDA-MB-175-VII MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJ5LkWwOVMh|ryP M2H5UXNCVkeHUh?=
JVM-2 NE\YVm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ5Lk[2NlIh|ryP NIC0NFhUSU6JRWK=
UACC-257 NYPufGdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HSemlEPTB;MkeuOlg4QCEQvF2= MVzTRW5ITVJ?
SW1783 NXXSSmtUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[wcGJ4UUN3ME2yO{44Pzh|IN88US=> NGTLTJBUSU6JRWK=
HT-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfuTWM2OD1{OD6yNVY3KM7:TR?= MljrV2FPT0WU
RL MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknWTWM2OD1{OD61PVEyKM7:TR?= NWL6TlloW0GQR1XS
TK10 M1mxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHvTWM2OD1{OD62OVM2KM7:TR?= M2DaRXNCVkeHUh?=
HT55 NVvTWWQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLBU5p4UUN3ME2yPU4xPTZ3IN88US=> M3nkRnNCVkeHUh?=
BT-20 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPCU4dQUUN3ME2yPU4xPTh4IN88US=> MXXTRW5ITVJ?
TGBC24TKB MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfqZVdKSzVyPUK5MlE5OzFizszN MXvTRW5ITVJ?
HSC-2 M{XRemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ7LkOwNFEh|ryP NWewO|hzW0GQR1XS
COLO-205 NIGwRY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV6zTZh2UUN3ME2yPU4{QTR2IN88US=> M2jJZXNCVkeHUh?=
GT3TKB MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jOVmlEPTB;MkmuOlg4PyEQvF2= NHTUVHNUSU6JRWK=
T47D MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[5[YxKSzVyPUK5Mlg2QDJizszN NFPQUJZUSU6JRWK=
OMC-1 NW\RWYZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jDcGlEPTB;M{CuNVkyQSEQvF2= MnmzV2FPT0WU
PFSK-1 M3fEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK3TWM2OD1|MT6yOlU6KM7:TR?= NVXwNHpQW0GQR1XS
JEG-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLiTWM2OD1|MT6zOVYyKM7:TR?= MYXTRW5ITVJ?
RD MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHnb|ZKSzVyPUOxMlUyOTVizszN MYDTRW5ITVJ?
NCI-H64 NHHmb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fQZWlEPTB;M{KuOFE4QSEQvF2= MlzyV2FPT0WU
DMS-114 M3nnVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK2WplYUUN3ME2zNk41OTh{IN88US=> NXLNb4NFW0GQR1XS
NCI-H661 NH\SNHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPodmhKSzVyPUOyMlY2ODFizszN NGDS[|RUSU6JRWK=
CAL-148 NHfEbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIiyfIdKSzVyPUOyMlY3PjVizszN M3ruRnNCVkeHUh?=
HuP-T3 NU\PR3F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXIVI0zUUN3ME2zNk46OzN6IN88US=> NYHWdFNGW0GQR1XS
ES4 NWK3U3NKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXvTWM2OD1|Mz6xO|A2KM7:TR?= M4fKR3NCVkeHUh?=
Ca9-22 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrFTWM2OD1|Mz60OlAyKM7:TR?= MXjTRW5ITVJ?
LP-1 NGrrXHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoriTWM2OD1|ND6wPUDPxE1? NXrXbFk{W0GQR1XS
AU565 Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTN2LkWwOlkh|ryP NVLy[WwzW0GQR1XS
MDA-MB-453 MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PJ[mlEPTB;M{WuNVQzPiEQvF2= NEXQflVUSU6JRWK=
SNU-C1 MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\2eGlEPTB;M{WuNVcyKM7:TR?= NGLjcYlUSU6JRWK=
SW13 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTN3LkSwO|Yh|ryP NXTWXFd2W0GQR1XS
NCI-H2122 NFO1fnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\vN|A1UUN3ME2zOU42PTl6IN88US=> MYXTRW5ITVJ?
NCI-H1395 NF\ZbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnrTWM2OD1|NT62OlkyKM7:TR?= Ml3mV2FPT0WU
J-RT3-T3-5 NEXEPGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\CPGhKSzVyPUO2MlAzQTRizszN MXrTRW5ITVJ?
COR-L279 M1LCU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrTTWM2OD1|Nj6xPVgyKM7:TR?= NV\Te5EyW0GQR1XS
ATN-1 NHLFZ|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn62TWM2OD1|Nj64OVE3KM7:TR?= NV:0e2lLW0GQR1XS
HCC2998 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFuwd3ZKSzVyPUO2Mlg2PzFizszN Mmi5V2FPT0WU
UM-UC-3 M3i5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T5bWlEPTB;M{[uPFY4PSEQvF2= NYC4WY5YW0GQR1XS
DV-90 NVGySXhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3wcoM{UUN3ME2zOk46ODZ5IN88US=> MWXTRW5ITVJ?
ES8 NXv2SHdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH21SFhKSzVyPUO2Mlk{OThizszN NFPuUolUSU6JRWK=
YAPC MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPNNG44UUN3ME2zOk46PjV2IN88US=> M3TZbHNCVkeHUh?=
HCC1599 M2O4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTN5LkG2NVgh|ryP M{TxNXNCVkeHUh?=
UMC-11 M3XnXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN5LkK1NFMh|ryP M3XTe3NCVkeHUh?=
THP-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTN5LkK4Olgh|ryP MYTTRW5ITVJ?
OCUB-M NUjJUmlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LHUWlEPTB;M{euNlg6OSEQvF2= MVPTRW5ITVJ?
NCI-H1693 M1Sxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHizOHNKSzVyPUO3MlMzOzNizszN MX\TRW5ITVJ?
NCI-H345 NW[wclZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorqTWM2OD1|Nz6zOlI1KM7:TR?= M{fYUnNCVkeHUh?=
COLO-800 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPBTWM2OD1|Nz61Olch|ryP NFjUUYxUSU6JRWK=
COLO-320-HSR Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTN6LkO0PVIh|ryP M3nmdnNCVkeHUh?=
NCI-H596 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPKTWM2OD1|OD60OFg6KM7:TR?= NHLTU4xUSU6JRWK=
NCI-H187 NYrlSGpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXjUXF2UUN3ME2zPE44OzR2IN88US=> NG\4O|BUSU6JRWK=
ECC4 M2jte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;NTWM2OD1|OT6wPFE1KM7:TR?= NFnvSWJUSU6JRWK=
KP-4 Mn3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTN7LkGyN|Uh|ryP MVHTRW5ITVJ?
NCI-H2227 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXS5NoVHUUN3ME2zPU4{QTR7IN88US=> MVnTRW5ITVJ?
22RV1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPkTWM2OD1|OT64N|k5KM7:TR?= NGLy[GpUSU6JRWK=
SAS MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3OwPWlEPTB;NECuNFk3KM7:TR?= MWrTRW5ITVJ?
PANC-10-05 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme1TWM2OD12MD6xPFI5KM7:TR?= M3fNWnNCVkeHUh?=
MDA-MB-468 MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;HNIRKSzVyPUSwMlU{PDZizszN NHn2W3NUSU6JRWK=
RPMI-7951 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DMT2lEPTB;NEGuNlA4PSEQvF2= NWjsSFd3W0GQR1XS
BB49-HNC NELHc2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTRzLkKxO|kh|ryP M4PVfXNCVkeHUh?=
23132-87 M1fCSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDBTWM2OD12MT6yO|MzKM7:TR?= NGTZO2VUSU6JRWK=
HCC1569 NX34NXF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fPRmlEPTB;NEGuNlg5PSEQvF2= Mkm1V2FPT0WU
CP66-MEL M17JUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXUTFhKSzVyPUSyMlE5QDZizszN M4nYWnNCVkeHUh?=
K-562 NIPITXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXCTWM2OD12Mj6yPFU1KM7:TR?= Mn33V2FPT0WU
OCI-AML2 NYPYOnh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrreYxYUUN3ME20Nk45QTd2IN88US=> NYjaXYUzW0GQR1XS
SW756 Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjjR5RKSzVyPUSzMlA{QDhizszN NFm1fIxUSU6JRWK=
M14 NVnrN4hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTR|LkOxPFkh|ryP MlLqV2FPT0WU
NCI-H1623 NXL0dI5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTR|LkS2OEDPxE1? NXftSnVRW0GQR1XS
KNS-81-FD M3LCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTR|Lke2NkDPxE1? NXH5SXRYW0GQR1XS
TGBC1TKB M1\ycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTaS|hUUUN3ME20N{46ODl7IN88US=> MUTTRW5ITVJ?
RERF-LC-MS NWLyXXlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXSTWM2OD12Mz65NlgyKM7:TR?= MUHTRW5ITVJ?
PC-3 MoPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\5WGlEPTB;NESuOFM1PyEQvF2= M1u5cHNCVkeHUh?=
HuP-T4 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzESJBKSzVyPUS0MlQ1PzRizszN MmLLV2FPT0WU
NCI-H510A NUPCfYxZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;j[GljUUN3ME20OE44ODhizszN MlHXV2FPT0WU
LB2518-MEL MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TkT2lEPTB;NESuO|k{PyEQvF2= NYTpTo1UW0GQR1XS
TE-5 NGT0dmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTCTWM2OD12NT65OVgyKM7:TR?= NFvFS5BUSU6JRWK=
EW-24 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTR4LkG3NlMh|ryP NF7XU|FUSU6JRWK=
LB647-SCLC M3n2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoC5TWM2OD12Nj6yNVU2KM7:TR?= MmPpV2FPT0WU
NCI-H524 NHLTeYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHRTWM2OD12Nj63NVg2KM7:TR?= Ml;yV2FPT0WU
EW-11 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG3TWM2OD12Nj65N|c{KM7:TR?= NEThcFhUSU6JRWK=
KALS-1 Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTR5LkKwOlYh|ryP MX\TRW5ITVJ?
BT-474 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi4eFQxUUN3ME20O{41OjF4IN88US=> M{Dr[nNCVkeHUh?=
SK-N-AS NX64NoRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTR5Lki4PEDPxE1? NX3LblVJW0GQR1XS
HCC2157 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTR6LkC3OkDPxE1? NIXaZZlUSU6JRWK=
HCC1954 M1HvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTR6LkG3NFQh|ryP Moe5V2FPT0WU
FADU Mmj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj0e5ZkUUN3ME20PE4{ODNzIN88US=> Mn2wV2FPT0WU
S-117 MoLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTR6LkO4NVUh|ryP M2TWT3NCVkeHUh?=
LS-1034 NVfUSXk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX4[XBYUUN3ME20PE44ODZ5IN88US=> M{nRPXNCVkeHUh?=
CAMA-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3zdm1TUUN3ME20PU42PTR|IN88US=> MYnTRW5ITVJ?
LU-134-A MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXPSnJKSzVyPUS5MlgxQDVizszN NX\wfWVUW0GQR1XS
NCI-H1838 MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvhbWVuUUN3ME20PU45ODh5IN88US=> MXzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]
臨床試験 AP24534 is currently under Phase II clinical trials in treatment with leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Peptide substrate phosphorylation assays with GST-Abl kinase domains The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.

細胞アッセイ: [2]

細胞株 Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
濃度 0-625 nM
反応時間 72 hours
実験の流れ Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat

動物実験: [1]

動物モデル Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
製剤 Dissolved in 25 mM citrate buffer, pH 2.75
投薬量 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
投与方法 Oral gavage once daily

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Ponatinib (AP24534) SDF
分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 3-(2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

文献中の引用 (25)

Frequently Asked Questions

  • Question 1
    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

    Answer: Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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