Ponatinib (AP24534)

製品コードS1490

Ponatinib (AP24534)化学構造

分子量(MW):532.56

Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。

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カスタマーフィードバック(3)

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

製品安全説明書

Bcr-Abl阻害剤の選択性比較

生物活性

製品説明 Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。
靶点
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro試験

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NFj6UFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\1clZKSzVyPUCuNFAxODByMEO1PUDPxE1? MYnTRW5ITVJ?
MV-4-11 NV\HSG4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnGTWM2OD1yLkCwNFA6PTZizszN NEnZWYhUSU6JRWK=
MEG-01 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnT[odtUUN3ME2wMlAxODF{ODFOwG0> M13YUnNCVkeHUh?=
LAMA-84 M1LQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jU[2lEPTB;MD6wNFAyPjVizszN M2TzfHNCVkeHUh?=
CGTH-W-1 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDmOZVKSzVyPUCuNFAyPjlizszN M3nhNnNCVkeHUh?=
KASUMI-1 M3LwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMECyNVch|ryP NXfvfHJHW0GQR1XS
BE-13 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L6VGlEPTB;MD6wNFI2QSEQvF2= MlzZV2FPT0WU
CTV-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn5TWM2OD1yLkCwOVIyKM7:TR?= MVTTRW5ITVJ?
NKM-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHFd21KSzVyPUCuNFA3PTVizszN M2DxPHNCVkeHUh?=
MONO-MAC-6 NVLhV4Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv6W2xzUUN3ME2wMlAxQDN5IN88US=> MlLrV2FPT0WU
A204 M4f0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2focmlEPTB;MD6wNVIyQCEQvF2= NEDtRVJUSU6JRWK=
GDM-1 M2LqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrqTWM2OD1yLkCxPFM{KM7:TR?= NWDhcItHW0GQR1XS
AN3-CA MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLzZWhKSzVyPUCuNFE5PzNizszN NVnqTINWW0GQR1XS
BL-70 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXyTWM2OD1yLkCyNVk6KM7:TR?= M3TRNHNCVkeHUh?=
Daudi MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvyPYlxUUN3ME2wMlAzPTN5IN88US=> NICzUlNUSU6JRWK=
KU812 NUfkd3RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPFT3NKSzVyPUCuNFI5PDhizszN MWTTRW5ITVJ?
KG-1 NGPBXIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXOT2xnUUN3ME2wMlA{Ojl2IN88US=> MVTTRW5ITVJ?
DOHH-2 MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r6Z2lEPTB;MD6wOFgxOyEQvF2= MnXwV2FPT0WU
HuO9 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmCwTWM2OD1yLkC1OFQ5KM7:TR?= NYTzcmlVW0GQR1XS
EB2 MoTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvoTWM2OD1yLkC1OVc3KM7:TR?= NXPRS2JGW0GQR1XS
G-402 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HSdWlEPTB;MD6wOlM1OSEQvF2= M4q0ZXNCVkeHUh?=
SU-DHL-1 MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP6TWM2OD1yLkC2N|c6KM7:TR?= Ml7zV2FPT0WU
NCI-H719 M3zG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;VTWlEPTB;MD6wO|g5QCEQvF2= NGfzXVdUSU6JRWK=
MLMA NF;JWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoflTWM2OD1yLkC5NFYh|ryP MkTjV2FPT0WU
KM12 NI\1XGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7Pcm9KSzVyPUCuNFk4OzdizszN M1y0U3NCVkeHUh?=
SUP-T1 NFfzWVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEm5PFIh|ryP MlnGV2FPT0WU
MZ1-PC NVXhcnF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWO5Z2ZIUUN3ME2wMlEyOzN4IN88US=> NFXzZlBUSU6JRWK=
MFE-296 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmewTWM2OD1yLkGxPFM6KM7:TR?= Ml:0V2FPT0WU
ALL-PO NV70clRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3WbpVKSzVyPUCuNVI1PDNizszN NUTvW3M6W0GQR1XS
GB-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rYXmlEPTB;MD6xNlUyOiEQvF2= MXLTRW5ITVJ?
SIG-M5 M4LNSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvtTWM2OD1yLkGzN|ch|ryP MmGwV2FPT0WU
P30-OHK MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fIV2lEPTB;MD6xOVY4OiEQvF2= M2TJOXNCVkeHUh?=
NCI-H716 NGDFcHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMU[yOlYh|ryP M{fYeHNCVkeHUh?=
MPP-89 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkSwTWM2OD1yLkG2PVM{KM7:TR?= MVLTRW5ITVJ?
SF126 NUTRXWdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvlTWM2OD1yLkG3NFY{KM7:TR?= Ml;3V2FPT0WU
CTB-1 Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMUezNVYh|ryP NXnIXJNWW0GQR1XS
CA46 M{OxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rrcGlEPTB;MD6xO|Q5QSEQvF2= M4rqS3NCVkeHUh?=
NCI-H520 NUfR[mJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ITWM2OD1yLkG3O|MzKM7:TR?= NXrOWW5HW0GQR1XS
CAL-85-1 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HTeGlEPTB;MD6xO|kzPyEQvF2= NHnKUWRUSU6JRWK=
NCI-H2342 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMUi1O|ch|ryP M3KxS3NCVkeHUh?=
697 M3;hRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfqT5BKSzVyPUCuNVg5PzFizszN NGjlbIVUSU6JRWK=
NY NH7C[4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PQWGlEPTB;MD6xPVI5PyEQvF2= NVXnRVZSW0GQR1XS
T98G M1LqcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;0dYtKSzVyPUCuNVk{OThizszN MlrwV2FPT0WU
NCI-H1703 M{T3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPBR3pKSzVyPUCuNVk3OTVizszN MoX0V2FPT0WU
NCI-H2087 M13SUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMkC0N|kh|ryP NEC5ZoRUSU6JRWK=
PF-382 M1jsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nGV2lEPTB;MD6yNFg4OyEQvF2= M2rPTXNCVkeHUh?=
HCT-116 NYLjPJkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMkGwOlkh|ryP MoCzV2FPT0WU
CAKI-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn76TWM2OD1yLkKxOlY3KM7:TR?= NFnaWnpUSU6JRWK=
CCF-STTG1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\YdY1QUUN3ME2wMlIzPDd3IN88US=> NWr2ZXBvW0GQR1XS
D-392MG NIDRSZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPlTWM2OD1yLkKzNVc4KM7:TR?= MWLTRW5ITVJ?
RT-112 NEToNFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMkO3PVUh|ryP MUTTRW5ITVJ?
MES-SA MlXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3USpVZUUN3ME2wMlI1OTh5IN88US=> NGfrbXBUSU6JRWK=
LC-2-ad Mn;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL6Uo1QUUN3ME2wMlI1OjZ3IN88US=> MVjTRW5ITVJ?
NOS-1 M4TwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoO0TWM2OD1yLkK0N|Y4KM7:TR?= M3XRfHNCVkeHUh?=
NALM-6 NH\ZVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILtXldKSzVyPUCuNlU2PDNizszN M17MenNCVkeHUh?=
TE-15 M{XZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP5fpF4UUN3ME2wMlI3ODlzIN88US=> NU[5V2lTW0GQR1XS
786-0 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfpS3dSUUN3ME2wMlI3OjJ6IN88US=> MmD6V2FPT0WU
IST-MES1 NHrX[ZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjvcXdWUUN3ME2wMlI3QDJ7IN88US=> MX7TRW5ITVJ?
KYSE-180 M1vFc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HXPGlEPTB;MD6yOlg6OSEQvF2= MX\TRW5ITVJ?
YT NITlR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMk[5O|Qh|ryP NIHaR2hUSU6JRWK=
A427 NEHvOHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH1bmtHUUN3ME2wMlI4OjZ2IN88US=> NYjXR4ZrW0GQR1XS
KYSE-450 NULje5Z5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\abWRKSzVyPUCuNlc{OjlizszN MnTXV2FPT0WU
HuH-7 NEHJW5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMke3OlMh|ryP MlrZV2FPT0WU
CAS-1 M{LuRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMkizNFMh|ryP Mm\aV2FPT0WU
KURAMOCHI NUTaOI9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMki0NVkh|ryP NUPsVYlQW0GQR1XS
ACHN MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLETWM2OD1yLkK5N|I{KM7:TR?= MkDxV2FPT0WU
HGC-27 M1qzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlO3TWM2OD1yLkK5N|U{KM7:TR?= MW\TRW5ITVJ?
A172 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HJOWlEPTB;MD6yPVU4PyEQvF2= NIrIWnBUSU6JRWK=
SNU-449 NY\5NFFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMkm5OlQh|ryP MlLxV2FPT0WU
SW982 NXftXIVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPPTWM2OD1yLkK5PVc5KM7:TR?= NVS1dXEyW0GQR1XS
EFO-21 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwM{C0NVEh|ryP M4ryT3NCVkeHUh?=
NCI-H2030 NFXmOXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq5O2RIUUN3ME2wMlMyOTZ2IN88US=> NVfmU|UyW0GQR1XS
HT-144 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\W[|hbUUN3ME2wMlMyOjhizszN NXnCZ5RyW0GQR1XS
MFE-280 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n4UGlEPTB;MD6zNVQ2OyEQvF2= M{DTOXNCVkeHUh?=
SK-LU-1 MkD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf5XFI6UUN3ME2wMlMyPDZ4IN88US=> MkDrV2FPT0WU
NCI-H2052 NIX1Z3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XI[mlEPTB;MD6zNVQ5PCEQvF2= NHrzXpJUSU6JRWK=
SK-HEP-1 NYjVc3ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwM{OzOlgh|ryP MmDjV2FPT0WU
QIMR-WIL MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwM{O0NlQh|ryP NFHtSoxUSU6JRWK=
A2780 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFu5d2NKSzVyPUCuN|Q{ODRizszN MWTTRW5ITVJ?
ACN NEHw[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTONWsxUUN3ME2wMlM1QDd|IN88US=> NHLaUmhUSU6JRWK=
BxPC-3 NYS1bndjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[wTWM2OD1yLkO0PVg6KM7:TR?= MVzTRW5ITVJ?
BCPAP NWjEfJc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofTTWM2OD1yLkO2NFAyKM7:TR?= M1O1R3NCVkeHUh?=
HOP-62 NHPyRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nzdmlEPTB;MD6zOlExPiEQvF2= M{LwOnNCVkeHUh?=
SW1710 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYqyXnFPUUN3ME2wMlM3PDV3IN88US=> NUnRdmFKW0GQR1XS
OPM-2 MoTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2njXGlEPTB;MD6zOlQ4OyEQvF2= NF7qNmNUSU6JRWK=
DBTRG-05MG MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonDTWM2OD1yLkO4NFU1KM7:TR?= MmrjV2FPT0WU
SK-MEL-24 MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rnb2lEPTB;MD6zPVc6OSEQvF2= Mm[wV2FPT0WU
8305C MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfYTWM2OD1yLkO5O|k{KM7:TR?= MUXTRW5ITVJ?
OVCAR-4 M17acmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLhNXhKSzVyPUCuOFE2QDZizszN M17YUnNCVkeHUh?=
HLE MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlziTWM2OD1yLkSxPFYh|ryP NEjBb41USU6JRWK=
NCI-H747 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPrTWM2OD1yLkSyNVM4KM7:TR?= M17XUXNCVkeHUh?=
SW780 M2fxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwNEKzOFYh|ryP M1[2d3NCVkeHUh?=
KYSE-150 NVj5Xo5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PDcmlEPTB;MD60NlQyPSEQvF2= NHnUdZlUSU6JRWK=
H4 NGHtcWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNEK0OVEh|ryP MWHTRW5ITVJ?
SW1088 NUDxSJFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G1emlEPTB;MD60OFM6KM7:TR?= NGPIU|lUSU6JRWK=
SF268 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnzTWM2OD1yLkS0PFYh|ryP NGrxVYxUSU6JRWK=
RT4 M2TQR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHMTWM2OD1yLkS1NVEyKM7:TR?= M1nke3NCVkeHUh?=
NCI-H522 M1v1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTLXXdKSzVyPUCuOFUzPyEQvF2= M2PxdXNCVkeHUh?=
LCLC-97TM1 MoP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KzTmlEPTB;MD60OlE6PSEQvF2= M1;afHNCVkeHUh?=
CAL-39 NUnRSplPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnNRnFQUUN3ME2wMlQ3PTF7IN88US=> MoDIV2FPT0WU
CAL-120 MnHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwNEe2OFMh|ryP M4WyUXNCVkeHUh?=
ESS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL1UIM5UUN3ME2wMlQ4QDJzIN88US=> M4HsVHNCVkeHUh?=
KARPAS-45 NUnUdIZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\OTWM2OD1yLkS4PVM{KM7:TR?= NUnNTmlWW0GQR1XS
DU-4475 M3jmeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwNEm1NVEh|ryP MVfTRW5ITVJ?
VMRC-RCZ NH\TXlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXNTWM2OD1yLkS5PVA1KM7:TR?= NH3CblBUSU6JRWK=
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NCI-H2452 MlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTFwOEmwO|Qh|ryP M2jRO3NCVkeHUh?=
SK-MEL-2 NHTkcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjQXG9YUUN3ME2xMlkxOjdzIN88US=> M2eyb3NCVkeHUh?=
OVCAR-5 M{fWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTFwOUC2O|Uh|ryP NIX1[5pUSU6JRWK=
SNG-M NUjJeZpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS2UHhNUUN3ME2xMlk2QDV6IN88US=> NUm4eY5OW0GQR1XS
A673 NFLxPFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W4RmlEPTB;MT65O|UyPiEQvF2= MWnTRW5ITVJ?
L-428 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;1TWM2OD1zLkm5NVc6KM7:TR?= M160d3NCVkeHUh?=
KM-H2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrYZWlKSzVyPUKuNFExQSEQvF2= MXnTRW5ITVJ?
MC-IXC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXXTWM2OD1{LkCyNlc{KM7:TR?= NFyyR41USU6JRWK=
COLO-678 NETrdIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvBbGtKSzVyPUKuNFQzODdizszN MWnTRW5ITVJ?
MEL-JUSO NGWwb3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEK3dlRKSzVyPUKuNFc5PTFizszN NXX4WpVrW0GQR1XS
HCC38 NXvrPZMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7ycmFKSzVyPUKuNFg1OzNizszN M3rjRnNCVkeHUh?=
UACC-62 NIjCXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjUdFVKSzVyPUKuNFg5PTVizszN M2DNSnNCVkeHUh?=
OAW-42 M3TrW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HtXmlEPTB;Mj6wPVcyOSEQvF2= MX7TRW5ITVJ?
LB996-RCC MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX2TWM2OD1{LkGzPFE4KM7:TR?= MYXTRW5ITVJ?
COR-L105 NV\RUnlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJwMU[zO|Mh|ryP MX\TRW5ITVJ?
RCC10RGB MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJwMUi1O|Yh|ryP MWDTRW5ITVJ?
A431 NX6zUJloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTESlIxUUN3ME2yMlE6ODF7IN88US=> MlXRV2FPT0WU
NCI-H292 M{jX[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrBTWM2OD1{LkKzPVUyKM7:TR?= MXjTRW5ITVJ?
SK-UT-1 NXHWOINRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXGd2pKSzVyPUKuN|MyQDRizszN M3TBfnNCVkeHUh?=
PANC-08-13 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G3OGlEPTB;Mj6zN|I{PSEQvF2= NILvO|lUSU6JRWK=
ST486 MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jnUGlEPTB;Mj60NVA1QCEQvF2= MVzTRW5ITVJ?
SJSA-1 NUTod4NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPWWGlkUUN3ME2yMlQyOjdzIN88US=> MWjTRW5ITVJ?
RKO Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofBTWM2OD1{LkSyNFI6KM7:TR?= M1Xpd3NCVkeHUh?=
NCI-H1793 MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnSTWM2OD1{LkS0NFI6KM7:TR?= MkXuV2FPT0WU
639-V NFS1d49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoO2TWM2OD1{LkS1N|gzKM7:TR?= M{nHXnNCVkeHUh?=
ES3 M3LNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\VbWVKSzVyPUKuOFk4OzdizszN NFzJTnNUSU6JRWK=
NCI-H1792 Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXWw[GNCUUN3ME2yMlU3QDJ4IN88US=> NWnpOpZLW0GQR1XS
NCI-H1651 M3n0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonKTWM2OD1{LkW4NlEh|ryP MWjTRW5ITVJ?
SN12C M1LOXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJwNUi0PFch|ryP MoXKV2FPT0WU
COLO-679 NWP0[3VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPvTWM2OD1{LkW4OlA2KM7:TR?= Mnf5V2FPT0WU
U-118-MG MmjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TjOGlEPTB;Mj61PFg4OiEQvF2= NX3lbo5TW0GQR1XS
Ramos-2G6-4C10 NGXKeHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHPW2hKSzVyPUKuOlQ5ODdizszN NGWwS2dUSU6JRWK=
HCT-15 NEmySINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDkTWM2OD1{Lk[4O|kzKM7:TR?= NGn4dINUSU6JRWK=
MDA-MB-157 MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJwN{C3OFch|ryP NX\CXlRjW0GQR1XS
K5 MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nvWWlEPTB;Mj63NVg1PSEQvF2= M2Hyc3NCVkeHUh?=
MKN45 NHLndlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJwN{OzOlYh|ryP NYjH[JFqW0GQR1XS
DMS-273 NX23NXFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJwN{W2N|Ih|ryP NW\ZNGpwW0GQR1XS
C8166 NHHxRWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO5cVFKSzVyPUKuO|g2OTNizszN M2j4SHNCVkeHUh?=
Calu-3 NXvhSlVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJwN{i5Olkh|ryP NFXGdHhUSU6JRWK=
SNB75 M2j0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfhRmVNUUN3ME2yMlg5PTN3IN88US=> MWPTRW5ITVJ?
BFTC-905 Mn;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nGXWlEPTB;Mj65NFE6OSEQvF2= NYLZd2JIW0GQR1XS
C-4-II MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf1[204UUN3ME2yMlkyOzV|IN88US=> NFmyOpFUSU6JRWK=
MS-1 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjTZXhNUUN3ME2yMlk3PzZ7IN88US=> M16xUnNCVkeHUh?=
A375 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHO[5FKSzVyPUOuNFgyQDRizszN MnrWV2FPT0WU
KYSE-70 NUXsbYEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUizTnlPUUN3ME2zMlA5QDh{IN88US=> Mlq1V2FPT0WU
KYSE-510 NIeyN3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLtNYdlUUN3ME2zMlExQTl3IN88US=> MXTTRW5ITVJ?
LN-405 NWLsXI5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTNwMUO1NVgh|ryP M{LsTHNCVkeHUh?=
BOKU NIPkc2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\LT3Y4UUN3ME2zMlE1OjV4IN88US=> M2e2bnNCVkeHUh?=
TE-10 NFXidIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrwb3JKSzVyPUOuNVc{PjJizszN M1XoVnNCVkeHUh?=
MKN1 NGTQTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHKTWM2OD1|LkG4OFg{KM7:TR?= M2fVUnNCVkeHUh?=
M059J MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknjTWM2OD1|LkKwNVc{KM7:TR?= NUHLepFqW0GQR1XS
GOTO Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjveZRKSzVyPUOuNlIxOzlizszN NV63fXdSW0GQR1XS
DK-MG M4P6Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlf0TWM2OD1|LkK1PVc3KM7:TR?= Mom0V2FPT0WU
NCI-H727 NXn4WZc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fYRWlEPTB;Mz6yOlU5KM7:TR?= M2rke3NCVkeHUh?=
NB12 Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYj1VmFCUUN3ME2zMlM{OjJ2IN88US=> MVrTRW5ITVJ?
DOK MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTNwM{[xPFYh|ryP MVfTRW5ITVJ?
KYSE-410 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnRc5NzUUN3ME2zMlM3Ojh5IN88US=> NUHTW3JWW0GQR1XS
AM-38 Moj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTNwM{iwOVEh|ryP MW\TRW5ITVJ?
GR-ST M3zrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYftc5h5UUN3ME2zMlQ2PzN{IN88US=> NVLtUZFVW0GQR1XS
D-247MG NEHkempIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XlWWlEPTB;Mz60PFI3OyEQvF2= M{L5V3NCVkeHUh?=
TE-8 M4j0cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDRTWM2OD1|LkS5N|M{KM7:TR?= NEPGTJhUSU6JRWK=
LS-411N NH;pPXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwNEm2PVIh|ryP M2fN[XNCVkeHUh?=
SK-MES-1 M1;q[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rzUGlEPTB;Mz61OlQ{OyEQvF2= MUXTRW5ITVJ?
SF295 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTNwNkG1OVIh|ryP NVfDTGROW0GQR1XS
SK-MEL-30 M2X4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTNwNkW5NlEh|ryP M3zPOXNCVkeHUh?=
LB2241-RCC NWnGRXhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTNwNk[yOkDPxE1? M13ofHNCVkeHUh?=
PC-14 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTNwNk[0N|ch|ryP NEDIWZJUSU6JRWK=
EW-7 NV7oeVc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTNwNke2PVMh|ryP NG\QenJUSU6JRWK=
NMC-G1 M4jlZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknmTWM2OD1|LkexPFM4KM7:TR?= M{fTSnNCVkeHUh?=
TE-441-T NEjKZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTNwN{OwNlgh|ryP MYrTRW5ITVJ?
NCI-H1618 NEj5c5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrzZoZrUUN3ME2zMlgyQDd3IN88US=> NVj6cIJxW0GQR1XS
PANC-03-27 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TZWGlEPTB;Mz64NVkyPiEQvF2= NFfHXHBUSU6JRWK=
NCI-H2228 M2PGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;VOVdKSzVyPUOuPFMyOjZizszN NHTXT3FUSU6JRWK=
CAPAN-1 NUPmUpFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTNwOEewNFkh|ryP M1G2TXNCVkeHUh?=
KLE M16xRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHoOVZzUUN3ME2zMlkxPjdizszN NUXwSZJFW0GQR1XS
Becker M4e0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\ZdmlEPTB;Mz65Nlg1QSEQvF2= M3HNSXNCVkeHUh?=
SK-PN-DW M2i2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPOTWM2OD12LkC3PVc1KM7:TR?= NVPQfWRKW0GQR1XS
Hs-578-T NF\LT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTRwMEizNFYh|ryP NYHOR5dtW0GQR1XS
RS4-11 NGS2PGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTRwMUGyOVUh|ryP MUHTRW5ITVJ?
D-502MG M4SwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\vUGZKSzVyPUSuNVY6QTdizszN NVK0dGtKW0GQR1XS
GI-1 MlfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTITWM2OD12LkK4Nlk6KM7:TR?= MlLwV2FPT0WU
NCI-H209 M2jxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL3eY5HUUN3ME20MlM{PzhizszN MWnTRW5ITVJ?
SK-OV-3 Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHzR3JSUUN3ME20MlQ5OTR7IN88US=> MmLhV2FPT0WU
LOUCY M{jV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPo[|ZKSzVyPUSuOFg1OzJizszN NH;lbI1USU6JRWK=
NCI-H69 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3lTWM2OD12LkWxO|k{KM7:TR?= NHvxUXpUSU6JRWK=
SCC-9 NWL0W5JVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfVTmRTUUN3ME20MlU{OTd{IN88US=> MWjTRW5ITVJ?
NCI-H526 NIDIO|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jHbGlEPTB;ND61PVI6OyEQvF2= M2G0eHNCVkeHUh?=
NCI-H2170 NUXReZJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrqUZJKSzVyPUSuOlY4PzFizszN M4\xe3NCVkeHUh?=
SR NFvGVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi3eItKSzVyPUSuO|AxPDhizszN MXjTRW5ITVJ?
CMK MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn22TWM2OD12LkeyNVAyKM7:TR?= MmTBV2FPT0WU
COLO-829 NYrzRo9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRwN{ewOFMh|ryP Mny3V2FPT0WU
HuO-3N1 M2DRU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTRwOEOyPFEh|ryP Ml7sV2FPT0WU
5637 NVOzO5V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTRwOUC0PFch|ryP MWXTRW5ITVJ?
A253 NFLWSJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzQU|U{UUN3ME20Mlk4PzB6IN88US=> NYq0RVRDW0GQR1XS
NB10 NFy0TohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MliyTWM2OD13LkC3OFk4KM7:TR?= MlPlV2FPT0WU
SF539 MlX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX0OohKSzVyPUWuNFk6PTlizszN NHvobXdUSU6JRWK=
HAL-01 M3vMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vDXGlEPTB;NT6xOFY1PSEQvF2= NFfMTHBUSU6JRWK=
MHH-ES-1 NIrjR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLGOlRkUUN3ME21MlE3QTJ3IN88US=> NW\EPGlZW0GQR1XS
DEL NFz1N|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTVwMke1PFIh|ryP MXzTRW5ITVJ?
NCI-H1299 NF\k[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;UTWM2OD13LkO1NFA4KM7:TR?= M4HJb3NCVkeHUh?=
ChaGo-K-1 M4LN[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfqWVJKSzVyPUWuN|UyODdizszN MV;TRW5ITVJ?
HMV-II NYTUT2FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLyZ|hKSzVyPUWuN|k1OyEQvF2= MWfTRW5ITVJ?
NB69 NH7GW4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fqNmlEPTB;NT6zPVY{OSEQvF2= NYfzb5FtW0GQR1XS
NCI-H1882 NE\yZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO2ZXlKSzVyPUWuOFM{PjRizszN MUXTRW5ITVJ?
SNU-475 NIC0U|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvwTWM2OD13LkS3NVcyKM7:TR?= NX\hdo5yW0GQR1XS
RXF393 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zrPWlEPTB;NT60PFQ6PCEQvF2= NXTqWW9vW0GQR1XS
CAL-51 NWfO[|NWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofxTWM2OD13Lk[yPFU{KM7:TR?= MoXOV2FPT0WU
SW1573 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXJTWM2OD13Lk[zOVM1KM7:TR?= MXfTRW5ITVJ?
GCT M3LkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vnemlEPTB;NT63OVkzQSEQvF2= MXXTRW5ITVJ?
COR-L88 MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DWZWlEPTB;NT63Olg1PiEQvF2= NWjUV252W0GQR1XS
MDA-MB-134-VI NG\LeplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTVwOEe1N|Yh|ryP MVTTRW5ITVJ?
NB5 MkW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HoU2lEPTB;NT65NlQ1KM7:TR?= MoT5V2FPT0WU
GMS-10 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnNXpBKSzVyPUWuPVY5PjFizszN Mlu0V2FPT0WU
CHP-212 NFTQ[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTZwNEiyOlch|ryP M1;sSHNCVkeHUh?=
TE-11 NYrjW2RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTZwNUWxPFIh|ryP NFXCbotUSU6JRWK=
SW962 M2\nV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS4WoZKSzVyPU[uOlU4PzRizszN MXXTRW5ITVJ?
MZ2-MEL MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\a[GlEPTB;Nj64NlAyOSEQvF2= M4fV[HNCVkeHUh?=
C-33-A M1zoVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjLTWM2OD14LkmxOlg5KM7:TR?= MnjhV2FPT0WU
IGR-1 NYjuW3BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHX1[HFKSzVyPU[uPVc5OjZizszN NHHtTI5USU6JRWK=
MOLT-4 MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYj0SYNPUUN3ME23MlE2PDB4IN88US=> NV3Yc|JpW0GQR1XS
NCI-H1650 MkfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTWT2hKSzVyPUeuNlcxPDZizszN NU\rN4xpW0GQR1XS
AsPC-1 MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTvfHBrUUN3ME23MlI5PjB3IN88US=> NF\LTIFUSU6JRWK=
SNU-C2B MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTdwMkm1O|Eh|ryP M3jRbnNCVkeHUh?=
MKN7 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTdwM{eyN|Uh|ryP M3\Ed3NCVkeHUh?=
SW620 NFrD[G9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvk[pZKSzVyPUeuN|gzODVizszN Mnq5V2FPT0WU
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COLO-792 NIWwV|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ{LkexNVEh|ryP M2DVNXNCVkeHUh?=
CAL-62 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3X2[WlEPTB;MkKuO|UyPyEQvF2= MkToV2FPT0WU
HCE-T MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjZbZhKSzVyPUKyMlg3ODZizszN MXHTRW5ITVJ?
BB65-RCC M1jXO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJ|LkCzOFQh|ryP MYrTRW5ITVJ?
SiHa MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPCOlJKSzVyPUKzMlM6PjhizszN MmjHV2FPT0WU
NCI-H2081 MkHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nzNmlEPTB;MkSuNFY1OSEQvF2= Mo\JV2FPT0WU
U251 Mor4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD6V2JKSzVyPUK0MlA3PjhizszN NGPqVmVUSU6JRWK=
LoVo NHPiUGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHrT2lKSzVyPUK0MlkzQDJizszN M1zKd3NCVkeHUh?=
GCIY NXr6SHVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLSfJNKSzVyPUK1MlI5PzdizszN MXnTRW5ITVJ?
NUGC-3 Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLXSWcyUUN3ME2yOU4{OzF4IN88US=> M3qwXHNCVkeHUh?=
LNCaP-Clone-FGC M3TjO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPLTWM2OD1{NT6zOFk5KM7:TR?= NYH4bXVEW0GQR1XS
PA-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJ3Lk[4N|Mh|ryP NIDwR2VUSU6JRWK=
OE33 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M130NmlEPTB;MkWuOlg2OyEQvF2= NELxZ3lUSU6JRWK=
HT-29 M{HndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXUbJlKSzVyPUK1Mlc5PzlizszN M4nPSHNCVkeHUh?=
RCM-1 Ml3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJ3Lkm2OVYh|ryP NXLjWmRvW0GQR1XS
NCI-H1522 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HFU2lEPTB;MkWuPVkyOSEQvF2= MlGzV2FPT0WU
LB373-MEL-D MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPmb4VKSzVyPUK2MlE4ODhizszN Mo\qV2FPT0WU
NCI-H1436 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC1TWM2OD1{Nj6yO|M5KM7:TR?= MYHTRW5ITVJ?
COLO-824 M1rNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm4enFKSzVyPUK2MlQxODJizszN MkLoV2FPT0WU
CP50-MEL-B MkLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP6SWlOUUN3ME2yOk42Pjd3IN88US=> NWfBepR{W0GQR1XS
EGI-1 NXHVOm9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\oTWM2OD1{Nz6yOlk5KM7:TR?= M1TWWXNCVkeHUh?=
LAN-6 MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTyU2hKSzVyPUK3MlM2QThizszN Ml3rV2FPT0WU
GAK NVLIfXRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjhd2tKSzVyPUK3MlQzOjVizszN MojEV2FPT0WU
MDA-MB-175-VII M1rOPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTDdFBRUUN3ME2yO{42ODV|IN88US=> NFzyfWlUSU6JRWK=
JVM-2 NETyW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq3TWM2OD1{Nz62OlIzKM7:TR?= MnXVV2FPT0WU
UACC-257 NHK4elZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\YeYdKSzVyPUK3MlY5PzhizszN MYXTRW5ITVJ?
SW1783 Ml3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{noV2lEPTB;MkeuO|c5OyEQvF2= MmHHV2FPT0WU
HT-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXGUo9TUUN3ME2yPE4zOTZ4IN88US=> MXjTRW5ITVJ?
RL M1XsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX3TWM2OD1{OD61PVEyKM7:TR?= NHu5PGNUSU6JRWK=
TK10 NF7IcGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LrVmlEPTB;MkiuOlU{PSEQvF2= NWrBZ4dSW0GQR1XS
HT55 NGnmdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTJ7LkC1OlUh|ryP Mo\GV2FPT0WU
BT-20 M4i0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJ7LkC1PFYh|ryP MYPTRW5ITVJ?
TGBC24TKB MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJ7LkG4N|Eh|ryP NX;s[FlJW0GQR1XS
HSC-2 NUXPdINsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJ7LkOwNFEh|ryP MX\TRW5ITVJ?
COLO-205 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjYNZZKSzVyPUK5MlM6PDRizszN M4DlUHNCVkeHUh?=
GT3TKB NF3Ee3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXJeVFKSzVyPUK5MlY5PzdizszN MmHQV2FPT0WU
T47D M4rr[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H5RmlEPTB;MkmuPFU5OiEQvF2= NELiVllUSU6JRWK=
OMC-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXLPYlKSzVyPUOwMlE6OTlizszN MoX3V2FPT0WU
PFSK-1 M3HDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITz[oxKSzVyPUOxMlI3PTlizszN MnTLV2FPT0WU
JEG-3 M4Hq[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTNzLkO1OlEh|ryP M3zTT3NCVkeHUh?=
RD M{PiXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvkO3ZUUUN3ME2zNU42OTF3IN88US=> MVvTRW5ITVJ?
NCI-H64 MmHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonUTWM2OD1|Mj60NVc6KM7:TR?= MUnTRW5ITVJ?
DMS-114 M{\jSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTN{LkSxPFIh|ryP M4HaXHNCVkeHUh?=
NCI-H661 NIXnfYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M320VmlEPTB;M{KuOlUxOSEQvF2= M13ycXNCVkeHUh?=
CAL-148 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnYTWM2OD1|Mj62OlY2KM7:TR?= NHjrWnFUSU6JRWK=
HuP-T3 NVrpWpZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS3TWM2OD1|Mj65N|M5KM7:TR?= M{TK[3NCVkeHUh?=
ES4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV30UZI2UUN3ME2zN{4yPzB3IN88US=> MnfkV2FPT0WU
Ca9-22 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvYTWM2OD1|Mz60OlAyKM7:TR?= NUS3OXBHW0GQR1XS
LP-1 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn4XYlKSzVyPUO0MlA6KM7:TR?= M2m5[nNCVkeHUh?=
AU565 NXPTfpVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHN[I1FUUN3ME2zOE42ODZ7IN88US=> NFfGS29USU6JRWK=
MDA-MB-453 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTN3LkG0NlYh|ryP MnfmV2FPT0WU
SNU-C1 NI\MbIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTN3LkG3NUDPxE1? MWnTRW5ITVJ?
SW13 MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLFVIM3UUN3ME2zOU41ODd4IN88US=> NFzQXlhUSU6JRWK=
NCI-H2122 NFruZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe2S3o5UUN3ME2zOU42PTl6IN88US=> NWrBZohWW0GQR1XS
NCI-H1395 NGPNNXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTN3Lk[2PVEh|ryP MVjTRW5ITVJ?
J-RT3-T3-5 NYPVNWl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X5TmlEPTB;M{[uNFI6PCEQvF2= MXXTRW5ITVJ?
COR-L279 NE\iTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj6NlRRUUN3ME2zOk4yQThzIN88US=> MXrTRW5ITVJ?
ATN-1 NILMbGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLTTWM2OD1|Nj64OVE3KM7:TR?= MU\TRW5ITVJ?
HCC2998 MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TkR2lEPTB;M{[uPFU4OSEQvF2= M4LFXnNCVkeHUh?=
UM-UC-3 M2f3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnhRnZKSzVyPUO2Mlg3PzVizszN NXfV[5N6W0GQR1XS
DV-90 NF:2c|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnwXpJUUUN3ME2zOk46ODZ5IN88US=> NVXTeJpvW0GQR1XS
ES8 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzwOVhYUUN3ME2zOk46OzF6IN88US=> MWLTRW5ITVJ?
YAPC MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTN4Lkm2OVQh|ryP MlXSV2FPT0WU
HCC1599 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELPTGZKSzVyPUO3MlE3OThizszN MULTRW5ITVJ?
UMC-11 NY\qZZpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTN5LkK1NFMh|ryP MlvVV2FPT0WU
THP-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3tOVQ5UUN3ME2zO{4zQDZ6IN88US=> MVjTRW5ITVJ?
OCUB-M NU\PfHdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTN5LkK4PVEh|ryP NGDkUFZUSU6JRWK=
NCI-H1693 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPPV3BKSzVyPUO3MlMzOzNizszN M3roSnNCVkeHUh?=
NCI-H345 MkDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnkS3dYUUN3ME2zO{4{PjJ2IN88US=> MYfTRW5ITVJ?
COLO-800 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL4NJRKSzVyPUO3MlU3PyEQvF2= MkHUV2FPT0WU
COLO-320-HSR NYfpc4lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPNd|B4UUN3ME2zPE4{PDl{IN88US=> NXLvOlQ6W0GQR1XS
NCI-H596 M4niS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTN6LkS0PFkh|ryP MVHTRW5ITVJ?
NCI-H187 NEXOS5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnuTWM2OD1|OD63N|Q1KM7:TR?= Mm\ZV2FPT0WU
ECC4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnFXZVmUUN3ME2zPU4xQDF2IN88US=> MkXyV2FPT0WU
KP-4 M{nFPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjPWFJKSzVyPUO5MlEzOzVizszN MlriV2FPT0WU
NCI-H2227 NFnTWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTN7LkO5OFkh|ryP Ml;DV2FPT0WU
22RV1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDL[JdKSzVyPUO5Mlg{QThizszN NFPDbYFUSU6JRWK=
SAS MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmmxTWM2OD12MD6wPVYh|ryP MmLNV2FPT0WU
PANC-10-05 M3jjcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTRyLkG4Nlgh|ryP NGTVU|JUSU6JRWK=
MDA-MB-468 Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTRyLkWzOFYh|ryP MX7TRW5ITVJ?
RPMI-7951 NGjuOGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTITWM2OD12MT6yNFc2KM7:TR?= NXnjWGNQW0GQR1XS
BB49-HNC MmCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrWTWM2OD12MT6yNVc6KM7:TR?= MXrTRW5ITVJ?
23132-87 NEfTfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW3TWM2OD12MT6yO|MzKM7:TR?= MYXTRW5ITVJ?
HCC1569 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnQOGNKSzVyPUSxMlI5QDVizszN NGXWNnhUSU6JRWK=
CP66-MEL NGeyfVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTR{LkG4PFYh|ryP MkTRV2FPT0WU
K-562 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULyfnAyUUN3ME20Nk4zQDV2IN88US=> MlPMV2FPT0WU
OCI-AML2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfLN3RKSzVyPUSyMlg6PzRizszN NVywe3lWW0GQR1XS
SW756 NUjifXN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj2TWM2OD12Mz6wN|g5KM7:TR?= M{faXHNCVkeHUh?=
M14 MnX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP4TWM2OD12Mz6zNVg6KM7:TR?= MXvTRW5ITVJ?
NCI-H1623 NY\KbYJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzyTWM2OD12Mz60OlQh|ryP MY\TRW5ITVJ?
KNS-81-FD M3nLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjkPHhKSzVyPUSzMlc3OiEQvF2= NWXa[YRNW0GQR1XS
TGBC1TKB M4f2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTR|LkmwPVkh|ryP NUfXbWl1W0GQR1XS
RERF-LC-MS NUXJXJhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1K5NGlEPTB;NEOuPVI5OSEQvF2= MmTUV2FPT0WU
PC-3 M2Tpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTR2LkSzOFch|ryP MlW4V2FPT0WU
HuP-T4 NIrXOpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKycnhKSzVyPUS0MlQ1PzRizszN MX3TRW5ITVJ?
NCI-H510A MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnezTWM2OD12ND63NFgh|ryP MVnTRW5ITVJ?
LB2518-MEL NGGzUnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTR2Lke5N|ch|ryP NVXPZndHW0GQR1XS
TE-5 NVvic2NJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoflTWM2OD12NT65OVgyKM7:TR?= NUDjNYcyW0GQR1XS
EW-24 NV\mbGt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP3XItKSzVyPUS2MlE4OjNizszN MV3TRW5ITVJ?
LB647-SCLC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3Ob4RKSzVyPUS2MlIyPTVizszN MWrTRW5ITVJ?
NCI-H524 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTR4LkexPFUh|ryP M3ewcnNCVkeHUh?=
EW-11 NF\RWmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\sV2lEPTB;NE[uPVM4OyEQvF2= NEXVd5FUSU6JRWK=
KALS-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHGTWM2OD12Nz6yNFY3KM7:TR?= NVflTpNUW0GQR1XS
BT-474 NGrId4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrsblBKSzVyPUS3MlQzOTZizszN NE\WR|VUSU6JRWK=
SK-N-AS MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXFNIxOUUN3ME20O{45QDhizszN MX\TRW5ITVJ?
HCC2157 M2PQc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTR6LkC3OkDPxE1? NX;Sd5ZLW0GQR1XS
HCC1954 NH7nd2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnnXWNxUUN3ME20PE4yPzB2IN88US=> MkG2V2FPT0WU
FADU MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT3TWM2OD12OD6zNFMyKM7:TR?= MnL5V2FPT0WU
S-117 NFO3UVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3jTWM2OD12OD6zPFE2KM7:TR?= NXywTlNFW0GQR1XS
LS-1034 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rpdWlEPTB;NEiuO|A3PyEQvF2= M4jBOHNCVkeHUh?=
CAMA-1 NYTrNVdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3QcoVKSzVyPUS5MlU2PDNizszN MVPTRW5ITVJ?
LU-134-A MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTR7LkiwPFUh|ryP NYH6XXZmW0GQR1XS
NCI-H1838 NWW2TWM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7MTHdXUUN3ME20PU45ODh5IN88US=> NF:z[XJUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

プロトコル(参考用のみ)

キナーゼアッセイ:[1]
+ 展開

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
細胞アッセイ: [2]
+ 展開
  • 細胞株: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • 濃度: 0-625 nM
  • 反応時間: 72 hours
  • 実験の流れ: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (参考用のみ)
動物実験:[1]
+ 展開
  • 動物モデル: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • 製剤: Dissolved in 25 mM citrate buffer, pH 2.75
  • 投薬量: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • 投与方法: Oral gavage once daily
    (参考用のみ)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
体内 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL

* <1 mg/mlは製品が微弱に溶解する或いは溶解しないことを示します。
* 溶解度検測はSelleck技術部門によって行いますので、文献より提供された溶解度と差異がある可能性がありますが、生産工芸と不同ロット(lot)で起きる正常な現象ですから、ご安心ください。

化学情報

分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管
in solvent
別名 N/A

便利ツール

モル濃度計算器

モル濃度計算器

解決のために必要とされるマス、ボリュームまたは濃度を計算してください。

マス (g) = 濃度 (mol/L) x ボリューム (L) x 分子量 (g/mol)

モル濃度計算器方程式

  • マス
    濃度
    ボリューム
    分子量

*貯蔵液を準備するとき、常に、オンであるとわかる製品のバッチに特有の分子量を使って、を通してラベルとMSDS/COA(製品ページで利用可能な)。

希釈計算器

希釈計算器

貯蔵液を準備することを要求される希釈剤を計算してください. セレック希釈計算器は、以下の方程式に基づきます:

開始濃度 x 開始体積 = 最終濃度 x 最終体積

希釈の計算式

この方程式は、一般に略語を使われます:C1V1 = C2V2 ( 輸入 輸出 )

  • C1
    V1
    C2
    V2

常に貯蔵液を準備するとき、小びんラベルとMSDS/COA(オンラインで利用できる)で見つかる製品のバッチに特有の分子量を使ってください。

連続希釈計算器方程式

  • 連続希釈剤

  • 計算結果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量計算器

分子量计算器

そのモル質量と元素組成を計算するために、合成物の化学式を入力してください:

総分子量:g/mol

チップス: 化学式は大文字と小文字の区別ができます。C10H16N2O2 c10h16n2o2

モル濃度計算器

マス 濃度 ボリューム 分子量

臨床試験

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

技術サポート

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

Handling Instructions

他の質問がある場合は、お気軽くお問合せください。

  • * 必須

よくある質問(FAQ)

  • 問題1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl信号経路図

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID