Ponatinib (AP24534) 化学構造
分子量: 532.56

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製品説明

  • Compare Bcr-Abl Inhibitors
    Bcr-Abl製品生物活性の比較
  • 研究分野
  • Ponatinib (AP24534)のメカニズム

製品の説明

生物活性

製品説明 Ponatinib (AP24534) は、PI3KγとPI4KIIIβの新しくて強力な阻害剤で、IC50 がそれぞれ16 nM と 19 nMになる。
ターゲット Abl PDGFRα VEGFR2 FGFR1 Src
IC50 0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM [1]
In vitro試験 AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell NFftNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rBeWlEPTB;MD6wNFAxODByM{W5JO69VQ>? NF62SFJUSU6JRWK=
MV-4-11 NVW3Z3pyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HIWGlEPTB;MD6wNFAxQTV4IN88US=> NIC2TnpUSU6JRWK=
MEG-01 M1rL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvuTWM2OD1yLkCwNFEzQCEQvF2= NV7UfHd2W0GQR1XS
LAMA-84 M4rTNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[zWIJlUUN3ME2wMlAxODF4NTFOwG0> NYjHeYFLW0GQR1XS
CGTH-W-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMECxOlkh|ryP M3jR[XNCVkeHUh?=
KASUMI-1 M37LbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMECyNVch|ryP NXi3dFh3W0GQR1XS
BE-13 MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rVbGlEPTB;MD6wNFI2QSEQvF2= M13yWHNCVkeHUh?=
CTV-1 NVvid3lUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jLTWlEPTB;MD6wNFUzOSEQvF2= NHfXSlZUSU6JRWK=
NKM-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDGTWM2OD1yLkCwOlU2KM7:TR?= MoHoV2FPT0WU
MONO-MAC-6 NUTDT3ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEf0NmhKSzVyPUCuNFA5OzdizszN MmezV2FPT0WU
A204 M1PvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX34bY9oUUN3ME2wMlAyOjF6IN88US=> NUjwNplHW0GQR1XS
GDM-1 M{LMVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEG4N|Mh|ryP NVm0fJlDW0GQR1XS
AN3-CA M373VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEG4O|Mh|ryP M4XyTHNCVkeHUh?=
BL-70 MmrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f4Z2lEPTB;MD6wNlE6QSEQvF2= MoS0V2FPT0WU
Daudi M{LETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DKT2lEPTB;MD6wNlU{PyEQvF2= MX\TRW5ITVJ?
KU812 Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHkdoFKSzVyPUCuNFI5PDhizszN M4fUfXNCVkeHUh?=
KG-1 M1LuUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXJbppXUUN3ME2wMlA{Ojl2IN88US=> NFTQdFFUSU6JRWK=
DOHH-2 NFzyUpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTYTWM2OD1yLkC0PFA{KM7:TR?= MkK0V2FPT0WU
HuO9 NYXndGM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHzdZRKSzVyPUCuNFU1PDhizszN NVfLfHJyW0GQR1XS
EB2 NF7LWXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMEW1O|Yh|ryP M{[wfXNCVkeHUh?=
G-402 NYPySlIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXtfVBKSzVyPUCuNFY{PDFizszN M4jRcXNCVkeHUh?=
SU-DHL-1 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK1d5pKSzVyPUCuNFY{PzlizszN NU\heG5FW0GQR1XS
NCI-H719 NEX5NFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLWTWM2OD1yLkC3PFg5KM7:TR?= MWHTRW5ITVJ?
MLMA Mn3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX3SYtOUUN3ME2wMlA6ODZizszN NFH2[2ZUSU6JRWK=
KM12 M1PwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj2S5ZKSzVyPUCuNFk4OzdizszN NGm2ZVVUSU6JRWK=
SUP-T1 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEm5PFIh|ryP MYPTRW5ITVJ?
MZ1-PC MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnx[oxKSzVyPUCuNVE{OzZizszN MV\TRW5ITVJ?
MFE-296 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T1TWlEPTB;MD6xNVg{QSEQvF2= M3jZNHNCVkeHUh?=
ALL-PO NHzpdWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXywVFVNUUN3ME2wMlEzPDR|IN88US=> M36wZnNCVkeHUh?=
GB-1 M2fne2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfITWM2OD1yLkGyOVEzKM7:TR?= M1e4THNCVkeHUh?=
SIG-M5 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTkdXI3UUN3ME2wMlE{OzdizszN NWfLRVl1W0GQR1XS
P30-OHK NULNTmN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMUW2O|Ih|ryP NHywWXdUSU6JRWK=
NCI-H716 MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFP5OIJKSzVyPUCuNVYzPjZizszN M4DGS3NCVkeHUh?=
MPP-89 Ml;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHvTWM2OD1yLkG2PVM{KM7:TR?= NFrKcGFUSU6JRWK=
SF126 NXnXNo1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXrN2ZKSzVyPUCuNVcxPjNizszN NInLbnJUSU6JRWK=
CTB-1 NIq2Z2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHiXGcyUUN3ME2wMlE4OzF4IN88US=> MXTTRW5ITVJ?
CA46 M1r3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL0TWM2OD1yLkG3OFg6KM7:TR?= NYHWdmNxW0GQR1XS
NCI-H520 NVToPVJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMUe3N|Ih|ryP Mn;VV2FPT0WU
CAL-85-1 M3XSZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfkfHdKSzVyPUCuNVc6OjdizszN NHm5c2tUSU6JRWK=
NCI-H2342 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\lW5ZKSzVyPUCuNVg2PzdizszN NXvORmQ6W0GQR1XS
697 NF7TeZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrR[XNIUUN3ME2wMlE5QDdzIN88US=> NHzLPVVUSU6JRWK=
NY MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVywV3dCUUN3ME2wMlE6Ojh5IN88US=> MorlV2FPT0WU
T98G MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3V[ZZsUUN3ME2wMlE6OzF6IN88US=> M2\LNXNCVkeHUh?=
NCI-H1703 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TzXWlEPTB;MD6xPVYyPSEQvF2= M2i1cnNCVkeHUh?=
NCI-H2087 NWfWW|Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1OyPWlEPTB;MD6yNFQ{QSEQvF2= NU\1SmRmW0GQR1XS
PF-382 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMkC4O|Mh|ryP NVn5fWVYW0GQR1XS
HCT-116 MoLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvNTWM2OD1yLkKxNFY6KM7:TR?= MoLsV2FPT0WU
CAKI-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMkG2OlYh|ryP MnPJV2FPT0WU
CCF-STTG1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlriTWM2OD1yLkKyOFc2KM7:TR?= NWfFSIlEW0GQR1XS
D-392MG MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMkOxO|ch|ryP M3nWdHNCVkeHUh?=
RT-112 NHvXT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD4SYN4UUN3ME2wMlI{Pzl3IN88US=> M3zpfHNCVkeHUh?=
MES-SA NXjqOWdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XPZWlEPTB;MD6yOFE5PyEQvF2= Ml7GV2FPT0WU
LC-2-ad MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzuXFdKSzVyPUCuNlQzPjVizszN MUnTRW5ITVJ?
NOS-1 Mor5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUi2VpNMUUN3ME2wMlI1OzZ5IN88US=> NV[1XI9TW0GQR1XS
NALM-6 MlLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XyO2lEPTB;MD6yOVU1OyEQvF2= Mn\wV2FPT0WU
TE-15 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETBUmpKSzVyPUCuNlYxQTFizszN MU\TRW5ITVJ?
786-0 M1XENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PDSGlEPTB;MD6yOlIzQCEQvF2= NGnOclJUSU6JRWK=
IST-MES1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnybHNPUUN3ME2wMlI3QDJ7IN88US=> M4LONnNCVkeHUh?=
KYSE-180 Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMk[4PVEh|ryP NFLxSYRUSU6JRWK=
YT NY\vUppGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMk[5O|Qh|ryP NUHR[Io4W0GQR1XS
A427 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDkRYVjUUN3ME2wMlI4OjZ2IN88US=> NWnTNo9NW0GQR1XS
KYSE-450 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrQbpYxUUN3ME2wMlI4OzJ7IN88US=> MY\TRW5ITVJ?
HuH-7 M1\z[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHP2fohKSzVyPUCuNlc4PjNizszN NY[zTpJ2W0GQR1XS
CAS-1 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrmU3JKSzVyPUCuNlg{ODNizszN M1L2V3NCVkeHUh?=
KURAMOCHI NXLYRXh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PPWGlEPTB;MD6yPFQyQSEQvF2= MmT6V2FPT0WU
ACHN MnKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PZWWlEPTB;MD6yPVMzOyEQvF2= NIPhRWZUSU6JRWK=
HGC-27 NF3hTmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYT2NHhmUUN3ME2wMlI6OzV|IN88US=> M1SxOXNCVkeHUh?=
A172 M2DjWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qxZmlEPTB;MD6yPVU4PyEQvF2= NHqzZWtUSU6JRWK=
SNU-449 MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHi[mlKSzVyPUCuNlk6PjRizszN M1LYVnNCVkeHUh?=
SW982 M{TBPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMkm5O|gh|ryP NXSwXJM{W0GQR1XS
EFO-21 Mnf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwM{C0NVEh|ryP MYHTRW5ITVJ?
NCI-H2030 MnLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwM{GxOlQh|ryP MonYV2FPT0WU
HT-144 M{fFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LCTWlEPTB;MD6zNVI5KM7:TR?= NXvXbZQ{W0GQR1XS
MFE-280 M2rmPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwM{G0OVMh|ryP M2LoNHNCVkeHUh?=
SK-LU-1 NIf0SZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkmwTWM2OD1yLkOxOFY3KM7:TR?= MlLQV2FPT0WU
NCI-H2052 MlPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwM{G0PFQh|ryP NH\mSGlUSU6JRWK=
SK-HEP-1 NEO3RplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;iTWM2OD1yLkOzN|Y5KM7:TR?= M1;u[3NCVkeHUh?=
QIMR-WIL NV7kVHNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwM{O0NlQh|ryP NVjSR|RCW0GQR1XS
A2780 NHfRPVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTBbXhKSzVyPUCuN|Q{ODRizszN NUTKeJJbW0GQR1XS
ACN MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTV[IRGUUN3ME2wMlM1QDd|IN88US=> M4fyWXNCVkeHUh?=
BxPC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr2XplEUUN3ME2wMlM1QTh7IN88US=> MVPTRW5ITVJ?
BCPAP M1TGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXPSY9CUUN3ME2wMlM3ODBzIN88US=> NF7rSIlUSU6JRWK=
HOP-62 MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwM{[xNFYh|ryP MkHnV2FPT0WU
SW1710 NFflephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwM{[0OVUh|ryP M1nuT3NCVkeHUh?=
OPM-2 MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O1bmlEPTB;MD6zOlQ4OyEQvF2= Mm[1V2FPT0WU
DBTRG-05MG MnzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwM{iwOVQh|ryP NXXEfmZFW0GQR1XS
SK-MEL-24 NIry[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLZTWM2OD1yLkO5O|kyKM7:TR?= MmLzV2FPT0WU
8305C MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPVT|ZFUUN3ME2wMlM6Pzl|IN88US=> NUTFUWZ5W0GQR1XS
OVCAR-4 MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXkXmpKSzVyPUCuOFE2QDZizszN NVzlSlJQW0GQR1XS
HLE MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;xVWlEPTB;MD60NVg3KM7:TR?= MkTRV2FPT0WU
NCI-H747 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3HTWM2OD1yLkSyNVM4KM7:TR?= NYjqRY9ZW0GQR1XS
SW780 MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\nTlBKSzVyPUCuOFI{PDZizszN M2\sR3NCVkeHUh?=
KYSE-150 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\1TWM2OD1yLkSyOFE2KM7:TR?= M3LkTXNCVkeHUh?=
H4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwNEK0OVEh|ryP M4joNHNCVkeHUh?=
SW1088 M3;4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;YcJlKSzVyPUCuOFQ{QSEQvF2= MWTTRW5ITVJ?
SF268 MmfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDjTWM2OD1yLkS0PFYh|ryP NF[wUpBUSU6JRWK=
RT4 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7jTGpGUUN3ME2wMlQ2OTFzIN88US=> MXXTRW5ITVJ?
NCI-H522 NWjuSmhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nLOWlEPTB;MD60OVI4KM7:TR?= NFfqN5VUSU6JRWK=
LCLC-97TM1 MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEe3bZNKSzVyPUCuOFYyQTVizszN MoPLV2FPT0WU
CAL-39 NXLwW3lpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzuTWM2OD1yLkS2OVE6KM7:TR?= MWjTRW5ITVJ?
CAL-120 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1n5fmlEPTB;MD60O|Y1OyEQvF2= NIC0U5FUSU6JRWK=
ESS-1 NHL6O2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwNEe4NlEh|ryP MYXTRW5ITVJ?
KARPAS-45 NVXwXod5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkWxTWM2OD1yLkS4PVM{KM7:TR?= NGLnZ41USU6JRWK=
DU-4475 NEfpWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXnTWM2OD1yLkS5OVEyKM7:TR?= M4rVWnNCVkeHUh?=
VMRC-RCZ MnG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwNEm5NFQh|ryP M2LL[XNCVkeHUh?=
HOS M2fpNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXSTWM2OD1yLkWwN|Y2KM7:TR?= NWO0eHRUW0GQR1XS
MOLT-16 M1\Bfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\hb2lEPTB;MD61NVgxQCEQvF2= NXzMb5VrW0GQR1XS
RPMI-6666 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwNUKxN|Uh|ryP NV3hdoppW0GQR1XS
K052 NIfLV5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXoTWM2OD1yLkWyNVQh|ryP MVXTRW5ITVJ?
EHEB NEjufoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPtTWM2OD1yLkWyNVgzKM7:TR?= NHviRlBUSU6JRWK=
MFH-ino MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjzTVBKSzVyPUCuOVI{PTFizszN NWfaeJVjW0GQR1XS
A4-Fuk MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHFTWM2OD1yLkWyOVI5KM7:TR?= NICxeGxUSU6JRWK=
SW1417 NFP2doZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4C1bmlEPTB;MD61Nlc5OSEQvF2= NV3VU5hJW0GQR1XS
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HCC38 NUDHV3FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfpc|ZKSzVyPUKuNFg1OzNizszN NYLDW41HW0GQR1XS
UACC-62 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJwMEi4OVUh|ryP MkDlV2FPT0WU
OAW-42 NH;DUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJwMEm3NVEh|ryP M3H0U3NCVkeHUh?=
LB996-RCC NGe4PWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLN[o04UUN3ME2yMlE{QDF5IN88US=> MmrkV2FPT0WU
COR-L105 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPyTWM2OD1{LkG2N|c{KM7:TR?= M3zZNXNCVkeHUh?=
RCC10RGB NIm0dpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJwMUi1O|Yh|ryP Ml7tV2FPT0WU
A431 M4PJd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:5O2VKSzVyPUKuNVkxOTlizszN M1LoT3NCVkeHUh?=
NCI-H292 NIrWc2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1izcGlEPTB;Mj6yN|k2OSEQvF2= NYm3ZodPW0GQR1XS
SK-UT-1 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYCwXlh2UUN3ME2yMlM{OTh2IN88US=> Mni0V2FPT0WU
PANC-08-13 MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf1dolWUUN3ME2yMlM{OjN3IN88US=> MVTTRW5ITVJ?
ST486 MnPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HVXWlEPTB;Mj60NVA1QCEQvF2= MVXTRW5ITVJ?
SJSA-1 M1vmeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle2TWM2OD1{LkSxNlcyKM7:TR?= M1\Yd3NCVkeHUh?=
RKO MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TzU2lEPTB;Mj60NlAzQSEQvF2= MW\TRW5ITVJ?
NCI-H1793 MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:5TWM2OD1{LkS0NFI6KM7:TR?= NU[x[VVpW0GQR1XS
639-V NYnteHByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJwNEWzPFIh|ryP MmHlV2FPT0WU
ES3 M2DWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T2RmlEPTB;Mj60PVc{PyEQvF2= NWfEXJV4W0GQR1XS
NCI-H1792 NGfKfJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXPdXdOUUN3ME2yMlU3QDJ4IN88US=> M3\K[HNCVkeHUh?=
NCI-H1651 M2iybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\5VGlEPTB;Mj61PFIyKM7:TR?= MoTBV2FPT0WU
SN12C MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XUd2lEPTB;Mj61PFQ5PyEQvF2= M1\hTnNCVkeHUh?=
COLO-679 MmDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS2TWM2OD1{LkW4OlA2KM7:TR?= NFnkWIFUSU6JRWK=
U-118-MG MmPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\6TFNKSzVyPUKuOVg5PzJizszN M3XnenNCVkeHUh?=
Ramos-2G6-4C10 NV\pSGdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrNT2dKSzVyPUKuOlQ5ODdizszN MV\TRW5ITVJ?
HCT-15 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJwNki3PVIh|ryP MXfTRW5ITVJ?
MDA-MB-157 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDXXpVQUUN3ME2yMlcxPzR5IN88US=> NGXiXGRUSU6JRWK=
K5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW2V5JXUUN3ME2yMlcyQDR3IN88US=> MUfTRW5ITVJ?
MKN45 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj3TWM2OD1{LkezN|Y3KM7:TR?= MY\TRW5ITVJ?
DMS-273 NY\I[lcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXztO5pqUUN3ME2yMlc2PjN{IN88US=> NHXobpdUSU6JRWK=
C8166 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPpTWM2OD1{Lke4OVE{KM7:TR?= MU\TRW5ITVJ?
Calu-3 NEHBPIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGSwe5FKSzVyPUKuO|g6PjlizszN M4PVO3NCVkeHUh?=
SNB75 NVrvZnE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfHPYpIUUN3ME2yMlg5PTN3IN88US=> MXjTRW5ITVJ?
BFTC-905 NX7GNXhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDSTWM2OD1{LkmwNVkyKM7:TR?= M3\yVnNCVkeHUh?=
C-4-II NGPkXllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnDW|N[UUN3ME2yMlkyOzV|IN88US=> NVTGNXRJW0GQR1XS
MS-1 MlfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH4TWM2OD1{Lkm2O|Y6KM7:TR?= NYK2[IM1W0GQR1XS
A375 NWe1UZpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDUTWM2OD1|LkC4NVg1KM7:TR?= NWfyfXpUW0GQR1XS
KYSE-70 Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTNwMEi4PFIh|ryP NF7TZ4ZUSU6JRWK=
KYSE-510 NFq5d3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LjSGlEPTB;Mz6xNFk6PSEQvF2= NWnZ[ZdqW0GQR1XS
LN-405 NXHUdGVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTNwMUO1NVgh|ryP MX7TRW5ITVJ?
BOKU M17xemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorZTWM2OD1|LkG0NlU3KM7:TR?= Mn\ZV2FPT0WU
TE-10 NXP1S2pST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkO1TWM2OD1|LkG3N|YzKM7:TR?= MmfvV2FPT0WU
MKN1 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH3TXBKSzVyPUOuNVg1QDNizszN MXrTRW5ITVJ?
M059J MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37jOmlEPTB;Mz6yNFE4OyEQvF2= NHOzU41USU6JRWK=
GOTO MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPoTWM2OD1|LkKyNFM6KM7:TR?= M3PZfXNCVkeHUh?=
DK-MG NF7COJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2GxOWlEPTB;Mz6yOVk4PiEQvF2= MUHTRW5ITVJ?
NCI-H727 M3XLUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\tb|F5UUN3ME2zMlI3PThizszN NIewTJlUSU6JRWK=
NB12 Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPsT3psUUN3ME2zMlM{OjJ2IN88US=> NXvtfXQ4W0GQR1XS
DOK M{XOVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fiUWlEPTB;Mz6zOlE5PiEQvF2= NIXTbZVUSU6JRWK=
KYSE-410 NFXCfldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLEU5F[UUN3ME2zMlM3Ojh5IN88US=> NIDDR4lUSU6JRWK=
AM-38 MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTNwM{iwOVEh|ryP NX33ToRIW0GQR1XS
GR-ST NILnSIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPxTWM2OD1|LkS1O|MzKM7:TR?= M4PBZnNCVkeHUh?=
D-247MG NHLlZpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\Ce2lEPTB;Mz60PFI3OyEQvF2= MV\TRW5ITVJ?
TE-8 M3TuTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlznTWM2OD1|LkS5N|M{KM7:TR?= MVnTRW5ITVJ?
LS-411N M2\UXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTNwNEm2PVIh|ryP NYe1c3hRW0GQR1XS
SK-MES-1 MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXVOIpKSzVyPUOuOVY1OzNizszN NFfXVmdUSU6JRWK=
SF295 M1jxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7ScWNVUUN3ME2zMlYyPTV{IN88US=> MXrTRW5ITVJ?
SK-MEL-30 M3zHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DFWmlEPTB;Mz62OVkzOSEQvF2= NXLnWlRpW0GQR1XS
LB2241-RCC MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK5RmxnUUN3ME2zMlY3OjZizszN M{LGTXNCVkeHUh?=
PC-14 M1zYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojzTWM2OD1|Lk[2OFM4KM7:TR?= M1fZbXNCVkeHUh?=
EW-7 NUXl[3RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj6UXNKSzVyPUOuOlc3QTNizszN MkPnV2FPT0WU
NMC-G1 M1i0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTNwN{G4N|ch|ryP MX3TRW5ITVJ?
TE-441-T NVfvb4NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnHeVcyUUN3ME2zMlc{ODJ6IN88US=> MmO5V2FPT0WU
NCI-H1618 NW\2U4RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HlU2lEPTB;Mz64NVg4PSEQvF2= NGPUbnZUSU6JRWK=
PANC-03-27 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDZfmtuUUN3ME2zMlgyQTF4IN88US=> M2T3TnNCVkeHUh?=
NCI-H2228 NYLRVFhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfqTYxKSzVyPUOuPFMyOjZizszN NXr4UXhwW0GQR1XS
CAPAN-1 NGnxdJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP3TWM2OD1|Lki3NFA6KM7:TR?= M1rK[3NCVkeHUh?=
KLE NI\PWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HmcGlEPTB;Mz65NFY4KM7:TR?= NE\BNlZUSU6JRWK=
Becker MorjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTNwOUK4OFkh|ryP Ml\4V2FPT0WU
SK-PN-DW NGX1XppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTRwMEe5O|Qh|ryP NHrZbY5USU6JRWK=
Hs-578-T Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4q3SmlEPTB;ND6wPFMxPiEQvF2= MVXTRW5ITVJ?
RS4-11 NWLpVnVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HGPWlEPTB;ND6xNVI2PSEQvF2= NEXzTIdUSU6JRWK=
D-502MG MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7tU3FKSzVyPUSuNVY6QTdizszN NX\TXWtKW0GQR1XS
GI-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRwMkiyPVkh|ryP M3;DXnNCVkeHUh?=
NCI-H209 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHDWXg4UUN3ME20MlM{PzhizszN MV7TRW5ITVJ?
SK-OV-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL1TWM2OD12LkS4NVQ6KM7:TR?= MojvV2FPT0WU
LOUCY NH;YZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL3bnpKSzVyPUSuOFg1OzJizszN NHnOenNUSU6JRWK=
NCI-H69 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRwNUG3PVMh|ryP NEG3T5NUSU6JRWK=
SCC-9 Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XUXGlEPTB;ND61N|E4OiEQvF2= NE[0Z3dUSU6JRWK=
NCI-H526 M4DWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTRwNUmyPVMh|ryP MXLTRW5ITVJ?
NCI-H2170 M2njV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Hqd2lEPTB;ND62Olc4OSEQvF2= MVPTRW5ITVJ?
SR MmrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{OycWlEPTB;ND63NFA1QCEQvF2= NHrsNXlUSU6JRWK=
CMK MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7EZXRKSzVyPUSuO|IyODFizszN MnPyV2FPT0WU
COLO-829 NYTrR5BYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljQTWM2OD12Lke3NFQ{KM7:TR?= M1XIbXNCVkeHUh?=
HuO-3N1 Mli0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTBRm9SUUN3ME20Mlg{OjhzIN88US=> NF;ndXdUSU6JRWK=
5637 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrldnVqUUN3ME20MlkxPDh5IN88US=> NVXJZpJQW0GQR1XS
A253 M3;CZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HRd2lEPTB;ND65O|cxQCEQvF2= NXGxS4htW0GQR1XS
NB10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLRTWM2OD13LkC3OFk4KM7:TR?= Mo[5V2FPT0WU
SF539 M{XhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTVwMEm5OVkh|ryP MVvTRW5ITVJ?
HAL-01 NIrqU2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLLTWM2OD13LkG0OlQ2KM7:TR?= MVLTRW5ITVJ?
MHH-ES-1 NHTBPZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoWwTWM2OD13LkG2PVI2KM7:TR?= MYHTRW5ITVJ?
DEL M4\ON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTVwMke1PFIh|ryP Mn7JV2FPT0WU
NCI-H1299 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i3OGlEPTB;NT6zOVAxPyEQvF2= NH3kO5JUSU6JRWK=
ChaGo-K-1 M1XzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz5[o83UUN3ME21MlM2OTB5IN88US=> M1PzN3NCVkeHUh?=
HMV-II M{j6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37pWmlEPTB;NT6zPVQ{KM7:TR?= MWnTRW5ITVJ?
NB69 NVzK[mVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXCPZd3UUN3ME21MlM6PjNzIN88US=> M4KzPXNCVkeHUh?=
NCI-H1882 MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTVwNEOzOlQh|ryP M2n0SnNCVkeHUh?=
SNU-475 NXzkRppHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvGTWM2OD13LkS3NVcyKM7:TR?= MkLBV2FPT0WU
RXF393 NEnPXpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTVwNEi0PVQh|ryP NFz6WYtUSU6JRWK=
CAL-51 NV:4S5g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7sTWM2OD13Lk[yPFU{KM7:TR?= NE\JSHVUSU6JRWK=
SW1573 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfsZ49KSzVyPUWuOlM2OzRizszN MWfTRW5ITVJ?
GCT NG\mPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHK[WZKSzVyPUWuO|U6OjlizszN M{Gxc3NCVkeHUh?=
COR-L88 M3mzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTVwN{[4OFYh|ryP MU\TRW5ITVJ?
MDA-MB-134-VI MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPjTWM2OD13Lki3OVM3KM7:TR?= MlWxV2FPT0WU
NB5 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4L6b2lEPTB;NT65NlQ1KM7:TR?= MXjTRW5ITVJ?
GMS-10 MnnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3oOmJKSzVyPUWuPVY5PjFizszN MWnTRW5ITVJ?
CHP-212 NUflPXZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4C4XGlEPTB;Nj60PFI3PyEQvF2= M4fteXNCVkeHUh?=
TE-11 M1jX[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LzUWlEPTB;Nj61OVE5OiEQvF2= M4jiOXNCVkeHUh?=
SW962 NWq4b4dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXaTWM2OD14Lk[1O|c1KM7:TR?= MVfTRW5ITVJ?
MZ2-MEL MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3BXXZVUUN3ME22MlgzODFzIN88US=> NGPCeHVUSU6JRWK=
C-33-A MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7pTWM2OD14LkmxOlg5KM7:TR?= NVLCeIJYW0GQR1XS
IGR-1 NXLNZZlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPTTWM2OD14Lkm3PFI3KM7:TR?= NGe4ZW1USU6JRWK=
MOLT-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\wO2lEPTB;Nz6xOVQxPiEQvF2= M4O3RnNCVkeHUh?=
NCI-H1650 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M12xOWlEPTB;Nz6yO|A1PiEQvF2= MW\TRW5ITVJ?
AsPC-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT2TWM2OD15LkK4OlA2KM7:TR?= NFXuUGtUSU6JRWK=
SNU-C2B MkSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTdwMkm1O|Eh|ryP MUTTRW5ITVJ?
MKN7 NFP3elVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zpZmlEPTB;Nz6zO|I{PSEQvF2= NF:4T4tUSU6JRWK=
SW620 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:yZ2lEPTB;Nz6zPFIxPSEQvF2= M{ThbXNCVkeHUh?=
SK-MEL-28 NYPPTGlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X6e2lEPTB;Nz60NFc6QCEQvF2= NEXMSG5USU6JRWK=
TE-6 NFiwO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTdwNES5NFgh|ryP Ml\CV2FPT0WU
D-263MG NGq4ZnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvt[4xKSzVyPUeuOFU4PjJizszN NX3KfWNQW0GQR1XS
NCI-H1355 NX:wXnlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTdwN{ewNlkh|ryP NYHqW5ppW0GQR1XS
DSH1 NWflW5RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTdwN{m3OlIh|ryP MoPOV2FPT0WU
NCI-H460 M13PW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDk[W1oUUN3ME24MlAxPjl2IN88US=> MVjTRW5ITVJ?
NCI-H1563 NULz[2F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRThwMEe1NFgh|ryP NEfScYJUSU6JRWK=
SW948 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjzfJVKSzVyPUiuNVA4PDRizszN NGPnbW5USU6JRWK=
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HT-1080 NYXodoV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PPOGlEPTB;OD6xN|E4PSEQvF2= NEPHNYNUSU6JRWK=
NCI-H441 NVrIOHRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\ZeZJKSzVyPUiuNVk{KM7:TR?= M2jIUHNCVkeHUh?=
HSC-4 NGD1WlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETYWFRKSzVyPUiuNlg4OiEQvF2= NYTKTHdWW0GQR1XS
LXF-289 NVn1TolOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK5TWM2OD16LkO1PVQ{KM7:TR?= MnnzV2FPT0WU
MRK-nu-1 NInvRXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXONodKSzVyPUiuN|Y{ODRizszN MVvTRW5ITVJ?
no-11 M1nzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfaNnNKSzVyPUiuOFcyOzNizszN NEK4XFFUSU6JRWK=
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Detroit562 NEfnOVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXlWW5OUUN3ME24Mlc2PDV3IN88US=> NWPkXmt3W0GQR1XS
SW954 NXW5XYxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHiOYZKSzVyPUiuO|Y5OzJizszN NIPXbGdUSU6JRWK=
P12-ICHIKAWA M3iwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj2VIJKSzVyPUiuO|g6PCEQvF2= NV\2fGY5W0GQR1XS
TE-9 NGHTOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnzTWM2OD16LkixNFYzKM7:TR?= NFPnRWxUSU6JRWK=
NB13 NED4RnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\JfGhQUUN3ME24Mlg{Pzl4IN88US=> MVvTRW5ITVJ?
BPH-1 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX4XVg1UUN3ME24Mlg2ODhzIN88US=> MmHIV2FPT0WU
KMOE-2 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRThwOEe4PVIh|ryP M4D2WnNCVkeHUh?=
RPMI-8402 NGm1U5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TpN2lEPTB;OD64PVkzPiEQvF2= NGXjfW9USU6JRWK=
OVCAR-3 M{jtO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITiUphKSzVyPUiuPVc4OzJizszN M{HISnNCVkeHUh?=
NCI-H2196 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7SU5pKSzVyPUiuPVg3ODZizszN MUnTRW5ITVJ?
MZ7-mel NUn5[5F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLITWM2OD17LkCzOFYh|ryP MXvTRW5ITVJ?
GP5d MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvyTlhSUUN3ME25MlA3OzF|IN88US=> Mk\GV2FPT0WU
NCI-N87 M3nHR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTlwNES3N|Eh|ryP MU\TRW5ITVJ?
EW-16 NGTuS5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTlwNES4OFgh|ryP MkK5V2FPT0WU
Calu-6 NEntSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3myT2lEPTB;OT60PVcxOyEQvF2= M1XDSXNCVkeHUh?=
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BC-1 MkXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPHTWM2OD17Lke4PVkh|ryP NFLBfIFUSU6JRWK=
NCI-SNU-16 M1TCRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDvTWM2OD17Lke5OFk2KM7:TR?= NFHkZlNUSU6JRWK=
NCI-H28 NHLEUnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm1UWhlUUN3ME25Mlg1QTN|IN88US=> NVfzWWV5W0GQR1XS
SBC-1 M3zrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T3NmlEPTB;MUCuNFczKM7:TR?= MV\TRW5ITVJ?
TUR MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX1OYlKSzVyPUGwMlE3PTdizszN MlSwV2FPT0WU
MDA-MB-231 NGPTRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTFyLkKxNVQh|ryP MW\TRW5ITVJ?
C3A NYn1XJJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXEbFhiUUN3ME2xNE4{OTd7IN88US=> MmS4V2FPT0WU
SW1990 NXfIVoZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFyLkOyPEDPxE1? MVTTRW5ITVJ?
NCI-H1993 NXnXboRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M16xRmlEPTB;MUCuOVY6OyEQvF2= MWfTRW5ITVJ?
SK-CO-1 NXXPNYRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFyLke3O{DPxE1? MWrTRW5ITVJ?
OAW-28 MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXqwWZdjUUN3ME2xNE46QDh6IN88US=> NGT2XItUSU6JRWK=
HN M1PWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvUVVlKUUN3ME2xNU4yOTNzIN88US=> NF:xXlBUSU6JRWK=
NCI-H1304 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7jTWM2OD1zMT6xOVc3KM7:TR?= MlPEV2FPT0WU
Daoy NYfrSZlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1j5cGlEPTB;MUGuOFM{PiEQvF2= MXXTRW5ITVJ?
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MCF7 NHvPXmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HmUGlEPTB;MUGuPFEzPiEQvF2= MVLTRW5ITVJ?
VM-CUB-1 Mom1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTFzLkmwPVEh|ryP MXjTRW5ITVJ?
IPC-298 NHrkcJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\5XWlEPTB;MUGuPVM5OyEQvF2= MmDRV2FPT0WU
NCI-H2126 M{W2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrnSpNKSzVyPUGyMlAzOThizszN NELFWZRUSU6JRWK=
OVCAR-8 M{T5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTF{LkGxOFEh|ryP MnHzV2FPT0WU
SJRH30 NWPjdGNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\YTWM2OD1zMj6yNlk6KM7:TR?= NV:1XpJ1W0GQR1XS
DMS-53 Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF{LkK2OFkh|ryP MVfTRW5ITVJ?
NCI-H322M MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjyTWM2OD1zMj6zN|U4KM7:TR?= NVq1WZVQW0GQR1XS
RVH-421 NH76cJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2KySWlEPTB;MUKuOFkxPCEQvF2= M3f4SXNCVkeHUh?=
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MDA-MB-415 M37hWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XmOWlEPTB;MUKuOlQ1PCEQvF2= MYnTRW5ITVJ?
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BFTC-909 M1r4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jrRWlEPTB;MUKuPVI1PyEQvF2= MmHMV2FPT0WU
BHY NYrCfWdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTF|LkOzPUDPxE1? MYHTRW5ITVJ?
YKG-1 M2PZNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTF|LkO3OFkh|ryP NIfteGtUSU6JRWK=
EW-3 M1ewS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInWe4xKSzVyPUGzMlcyPjNizszN MVXTRW5ITVJ?
HCC1143 M1TwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;YRYNMUUN3ME2xN{44PDN5IN88US=> MofjV2FPT0WU
REH MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\xTWM2OD1zMz64PVgzKM7:TR?= MVXTRW5ITVJ?
CESS M3LReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTF|Lkm0PFkh|ryP MUXTRW5ITVJ?
EFM-19 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonQTWM2OD1zND6xNVEzKM7:TR?= MVXTRW5ITVJ?
U031 MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF2LkSwPFUh|ryP M1;jRXNCVkeHUh?=
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LOXIMVI MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTF2LkewOlgh|ryP M3GwXXNCVkeHUh?=
A388 Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe0NZZKSzVyPUG0Mlc2PTZizszN NEf0RYhUSU6JRWK=
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Capan-2 M{f5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuxTWM2OD1zND63PFYh|ryP MYrTRW5ITVJ?
SKG-IIIa MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTF2Lki4OlIh|ryP MXXTRW5ITVJ?
HEL MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\6fGlEPTB;MUSuPFk6PyEQvF2= MlKzV2FPT0WU
BEN M3zTbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfJSJlKSzVyPUG0Mlk4PjZizszN MoPyV2FPT0WU
MC116 MkfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf6d3dwUUN3ME2xOU4yPTl7IN88US=> NUC2eG5yW0GQR1XS
IGROV-1 NWDmVZhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknMTWM2OD1zNT6yN|E4KM7:TR?= MmDUV2FPT0WU
NCI-H1648 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDNTWM2OD1zNT61N|A2KM7:TR?= MlHuV2FPT0WU
ABC-1 MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTF3LkiwN|Mh|ryP NYHLWpRlW0GQR1XS
EW-18 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j4VGlEPTB;MUWuPVk4QSEQvF2= NHvrbJhUSU6JRWK=
BC-3 NWHYU3lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvmOGdKUUN3ME2xOk4xPTZ{IN88US=> MXrTRW5ITVJ?
NCI-H1437 NI\ZOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TLXmlEPTB;MU[uNFY3PyEQvF2= MnLPV2FPT0WU
SCC-15 NHmyOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLPU2M{UUN3ME2xOk4zQDJ3IN88US=> NYXtcWhyW0GQR1XS
TT NFuxO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3u5eGlEPTB;MU[uOVg5QCEQvF2= MV3TRW5ITVJ?
KINGS-1 M1nBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorDTWM2OD1zNj64Nlc{KM7:TR?= NVjvUmV1W0GQR1XS
C32 M{Wz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjNdnZKSzVyPUG2Mlk4OTdizszN NHjEbVdUSU6JRWK=
SBC-5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTF5LkG0O|kh|ryP MmTFV2FPT0WU
NB1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\lTWM2OD1zNz6zNVg5KM7:TR?= MWTTRW5ITVJ?
EB-3 NInS[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S2c2lEPTB;MUeuOVc3KM7:TR?= M4Pud3NCVkeHUh?=
NCI-H748 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zvdWlEPTB;MUeuO|A{PSEQvF2= M2n3bnNCVkeHUh?=
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NCI-H226 NITNUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF5Lkm1OFYh|ryP NYjIXYk2W0GQR1XS
CAL-33 NH3tS|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF6LkK3PFEh|ryP M3foO3NCVkeHUh?=
SCC-4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fub2lEPTB;MUiuN|IzQSEQvF2= NU\GeVh4W0GQR1XS
RMG-I MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHwbJlNUUN3ME2xPE43QTR5IN88US=> M3TqenNCVkeHUh?=
KOSC-2 NGrsV5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF6Lke3OFYh|ryP MlvEV2FPT0WU
A2058 M1\ITWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1L0b2lEPTB;MUiuPFI2PSEQvF2= NF3lVWlUSU6JRWK=
HCC70 NEfEdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF7LkO4PVQh|ryP NYnDbHRzW0GQR1XS
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CAL-72 NWjVbFN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DxZmlEPTB;MUmuOlc{PyEQvF2= NIDSXmFUSU6JRWK=
L-363 M{Lrdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPteG5KSzVyPUKwMlAzOTJizszN NX7lblMzW0GQR1XS
SNU-423 NHrSTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rGVWlEPTB;MkCuNVA1OyEQvF2= MkizV2FPT0WU
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DMS-79 NFrFZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3O0T2lEPTB;MkCuPFQ6KM7:TR?= M124cHNCVkeHUh?=
Saos-2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3LTWM2OD1{MD65OVU3KM7:TR?= M17BbXNCVkeHUh?=
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SW837 NIjrdnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJzLkS5N|kh|ryP NXPSeIcxW0GQR1XS
SHP-77 MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ewW2lEPTB;MkGuOlEzOiEQvF2= MVHTRW5ITVJ?
DB MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHv1XGJKSzVyPUKxMlYyPDJizszN MWLTRW5ITVJ?
ES5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\tTWM2OD1{MT62PFY1KM7:TR?= M{C3b3NCVkeHUh?=
COR-L23 NFG4ZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LwN2lEPTB;MkGuPFA2OSEQvF2= MX\TRW5ITVJ?
KU-19-19 NWXiOpBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJzLki5PFIh|ryP MV7TRW5ITVJ?
T84 MojjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJzLkm4NVkh|ryP NInpW41USU6JRWK=
NCI-H630 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW4dHhwUUN3ME2yNk42OzZ|IN88US=> MlXPV2FPT0WU
LU-165 M3PGbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr2UYlKSzVyPUKyMlU2PCEQvF2= M3Tt[3NCVkeHUh?=
COLO-792 M4Lkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3FTWM2OD1{Mj63NVEyKM7:TR?= MnL3V2FPT0WU
CAL-62 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP2SXVDUUN3ME2yNk44PTF5IN88US=> NIrZZlhUSU6JRWK=
HCE-T MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3OxWGlEPTB;MkKuPFYxPiEQvF2= MVLTRW5ITVJ?
BB65-RCC M3rlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP0[XhmUUN3ME2yN{4xOzR2IN88US=> M4\VcXNCVkeHUh?=
SiHa MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDw[3FKSzVyPUKzMlM6PjhizszN MUjTRW5ITVJ?
NCI-H2081 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILX[4hKSzVyPUK0MlA3PDFizszN MU\TRW5ITVJ?
U251 NGf5enFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fkTmlEPTB;MkSuNFY3QCEQvF2= MkLvV2FPT0WU
LoVo NI\RSFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D6UGlEPTB;MkSuPVI5OiEQvF2= MWTTRW5ITVJ?
GCIY NEj1c2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJ3LkK4O|ch|ryP MUTTRW5ITVJ?
NUGC-3 M2O3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vueWlEPTB;MkWuN|MyPiEQvF2= M2npXXNCVkeHUh?=
LNCaP-Clone-FGC M13TOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJ3LkO0PVgh|ryP NEPKeVJUSU6JRWK=
PA-1 M2\lTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml25TWM2OD1{NT62PFM{KM7:TR?= M4TzfHNCVkeHUh?=
OE33 NYLxS45UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PadGlEPTB;MkWuOlg2OyEQvF2= MnPjV2FPT0WU
HT-29 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3wTWM2OD1{NT63PFc6KM7:TR?= MWXTRW5ITVJ?
RCM-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LhU2lEPTB;MkWuPVY2PiEQvF2= NV;jdIRsW0GQR1XS
NCI-H1522 M3z1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHOzdo5KSzVyPUK1Mlk6OTFizszN M1fjUHNCVkeHUh?=
LB373-MEL-D MofZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPuTWM2OD1{Nj6xO|A5KM7:TR?= NWL1dm1JW0GQR1XS
NCI-H1436 M3n6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\FTWM2OD1{Nj6yO|M5KM7:TR?= NF3rV|FUSU6JRWK=
COLO-824 MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYToU286UUN3ME2yOk41ODB{IN88US=> MV7TRW5ITVJ?
CP50-MEL-B MlfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LUSWlEPTB;Mk[uOVY4PSEQvF2= M{\D[XNCVkeHUh?=
EGI-1 NWrlZlFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJ5LkK2PVgh|ryP NW[3fHh6W0GQR1XS
LAN-6 MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfuTWM2OD1{Nz6zOVk5KM7:TR?= NW\QfFd4W0GQR1XS
GAK M1\oNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\pcmFKSzVyPUK3MlQzOjVizszN M{\tb3NCVkeHUh?=
MDA-MB-175-VII MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPlTWM2OD1{Nz61NFU{KM7:TR?= NX7acHU3W0GQR1XS
JVM-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnq3TWM2OD1{Nz62OlIzKM7:TR?= M1W0UXNCVkeHUh?=
UACC-257 NEL0T2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P5UGlEPTB;MkeuOlg4QCEQvF2= Mo\XV2FPT0WU
SW1783 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D5UWlEPTB;MkeuO|c5OyEQvF2= NWfvUJJpW0GQR1XS
HT-3 M4K1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzZR|FEUUN3ME2yPE4zOTZ4IN88US=> MW\TRW5ITVJ?
RL M3v0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJ6LkW5NVEh|ryP M2mwRnNCVkeHUh?=
TK10 MlnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\0UGRKSzVyPUK4MlY2OzVizszN M1XD[3NCVkeHUh?=
HT55 M1jhVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYm1b24{UUN3ME2yPU4xPTZ3IN88US=> MXTTRW5ITVJ?
BT-20 M3PZZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fuS2lEPTB;MkmuNFU5PiEQvF2= MkS5V2FPT0WU
TGBC24TKB M130O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnr1TWM2OD1{OT6xPFMyKM7:TR?= MVvTRW5ITVJ?
HSC-2 MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPoTWM2OD1{OT6zNFAyKM7:TR?= MYfTRW5ITVJ?
COLO-205 NFLRV|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW2cpdKSzVyPUK5MlM6PDRizszN NUjZN5hXW0GQR1XS
GT3TKB NVPDXXo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXycYI6UUN3ME2yPU43QDd5IN88US=> NEKzd3ZUSU6JRWK=
T47D MnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJ7Lki1PFIh|ryP NIXJXplUSU6JRWK=
OMC-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonXTWM2OD1|MD6xPVE6KM7:TR?= NXvSeFczW0GQR1XS
PFSK-1 MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvCSI9KSzVyPUOxMlI3PTlizszN NVvh[48{W0GQR1XS
JEG-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofHTWM2OD1|MT6zOVYyKM7:TR?= M3jIfXNCVkeHUh?=
RD MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTETWM2OD1|MT61NVE2KM7:TR?= NELPfHVUSU6JRWK=
NCI-H64 MmLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17UU2lEPTB;M{KuOFE4QSEQvF2= Mn25V2FPT0WU
DMS-114 NGLUT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXm1dmw{UUN3ME2zNk41OTh{IN88US=> MYnTRW5ITVJ?
NCI-H661 NVr0T5ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTN{Lk[1NFEh|ryP NITxS5JUSU6JRWK=
CAL-148 MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTtVokzUUN3ME2zNk43PjZ3IN88US=> NYPBc4hJW0GQR1XS
HuP-T3 M4jsZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDQdFJKSzVyPUOyMlk{OzhizszN Mnu4V2FPT0WU
ES4 MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XhSmlEPTB;M{OuNVcxPSEQvF2= M4G1OXNCVkeHUh?=
Ca9-22 NEPyR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPWTWM2OD1|Mz60OlAyKM7:TR?= M3X3TXNCVkeHUh?=
LP-1 NVjYNHBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTN2LkC5JO69VQ>? Mln3V2FPT0WU
AU565 MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ryfGlEPTB;M{SuOVA3QSEQvF2= M{D1VHNCVkeHUh?=
MDA-MB-453 MkTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvqV4U6UUN3ME2zOU4yPDJ4IN88US=> NGDKOFhUSU6JRWK=
SNU-C1 M1eyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTN3LkG3NUDPxE1? NInWXIhUSU6JRWK=
SW13 M3LseGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3oZohKSzVyPUO1MlQxPzZizszN NFPCUndUSU6JRWK=
NCI-H2122 M3jjZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D1[2lEPTB;M{WuOVU6QCEQvF2= M{Xxd3NCVkeHUh?=
NCI-H1395 NInMSXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;XZos6UUN3ME2zOU43PjlzIN88US=> MY\TRW5ITVJ?
J-RT3-T3-5 MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWzepZKSzVyPUO2MlAzQTRizszN MlXEV2FPT0WU
COR-L279 NEXkeHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPsWWhKSzVyPUO2MlE6QDFizszN NG\LOnZUSU6JRWK=
ATN-1 NIrGNWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzRcJpKSzVyPUO2Mlg2OTZizszN NIH1cWxUSU6JRWK=
HCC2998 NHfVZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n5NGlEPTB;M{[uPFU4OSEQvF2= MVjTRW5ITVJ?
UM-UC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33UPGlEPTB;M{[uPFY4PSEQvF2= M3LnO3NCVkeHUh?=
DV-90 NF3Wem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTN4LkmwOlch|ryP MXXTRW5ITVJ?
ES8 NVr0RWJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN4LkmzNVgh|ryP MWfTRW5ITVJ?
YAPC NYXhc5M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3mxNWlEPTB;M{[uPVY2PCEQvF2= M3yxT3NCVkeHUh?=
HCC1599 M3jTfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrINplKSzVyPUO3MlE3OThizszN Mmn1V2FPT0WU
UMC-11 NY[zUnQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN5LkK1NFMh|ryP M4XLdHNCVkeHUh?=
THP-1 NUfHfIpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfo[YxKSzVyPUO3MlI5PjhizszN NXvIN4lQW0GQR1XS
OCUB-M M1LWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfvboJ3UUN3ME2zO{4zQDlzIN88US=> NYLSW4NGW0GQR1XS
NCI-H1693 M4rnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS5U5dCUUN3ME2zO{4{OjN|IN88US=> MXfTRW5ITVJ?
NCI-H345 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm0R4lKSzVyPUO3MlM3OjRizszN M3S3WHNCVkeHUh?=
COLO-800 NInifHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojjTWM2OD1|Nz61Olch|ryP NH3ReXpUSU6JRWK=
COLO-320-HSR M1nWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTN6LkO0PVIh|ryP M4jkdXNCVkeHUh?=
NCI-H596 NFjrOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP5TWM2OD1|OD60OFg6KM7:TR?= NHHxdpFUSU6JRWK=
NCI-H187 NILHeYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHsR5c6UUN3ME2zPE44OzR2IN88US=> MYfTRW5ITVJ?
ECC4 NIXiVmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ntVGlEPTB;M{muNFgyPCEQvF2= MXjTRW5ITVJ?
KP-4 MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITI[FNKSzVyPUO5MlEzOzVizszN NF;FSY5USU6JRWK=
NCI-H2227 NX74cnNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofJTWM2OD1|OT6zPVQ6KM7:TR?= NYPYclVkW0GQR1XS
22RV1 NXK4XY1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHuT4pKSzVyPUO5Mlg{QThizszN MY\TRW5ITVJ?
SAS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i2fWlEPTB;NECuNFk3KM7:TR?= MljNV2FPT0WU
PANC-10-05 NYW5OFJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTRyLkG4Nlgh|ryP MoPhV2FPT0WU
MDA-MB-468 M2XHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jkdWlEPTB;NECuOVM1PiEQvF2= MoW4V2FPT0WU
RPMI-7951 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLoN4hKSzVyPUSxMlIxPzVizszN M4XjN3NCVkeHUh?=
BB49-HNC NF3ZcFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7aO|kyUUN3ME20NU4zOTd7IN88US=> M1n5fHNCVkeHUh?=
23132-87 NYL5SFRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Prb2lEPTB;NEGuNlc{OiEQvF2= M161d3NCVkeHUh?=
HCC1569 NEO0eJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXyTWM2OD12MT6yPFg2KM7:TR?= M3:1PHNCVkeHUh?=
CP66-MEL M{i3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X0UWlEPTB;NEKuNVg5PiEQvF2= MXrTRW5ITVJ?
K-562 M4\uR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rX[2lEPTB;NEKuNlg2PCEQvF2= NUHMTnhtW0GQR1XS
OCI-AML2 MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVmxUWp3UUN3ME20Nk45QTd2IN88US=> NIKw[FNUSU6JRWK=
SW756 MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHybHVKSzVyPUSzMlA{QDhizszN NWXNdWMyW0GQR1XS
M14 NEW2PGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fpeWlEPTB;NEOuN|E5QSEQvF2= NEfk[phUSU6JRWK=
NCI-H1623 NGnkN4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnhdFNKSzVyPUSzMlQ3PCEQvF2= M3XSUHNCVkeHUh?=
KNS-81-FD NF3vRYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF63UGxKSzVyPUSzMlc3OiEQvF2= MnnRV2FPT0WU
TGBC1TKB MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfaSphKSzVyPUSzMlkxQTlizszN MXfTRW5ITVJ?
RERF-LC-MS MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTR|LkmyPFEh|ryP NY\Le2lOW0GQR1XS
PC-3 NX30VpFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTR2LkSzOFch|ryP M1XlcnNCVkeHUh?=
HuP-T4 NXS4R242T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnEeoxKSzVyPUS0MlQ1PzRizszN NVvtNHpkW0GQR1XS
NCI-H510A NEPFdGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTR2LkewPEDPxE1? NWjBbIdMW0GQR1XS
LB2518-MEL M3zxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTsV24yUUN3ME20OE44QTN5IN88US=> NE\mOGNUSU6JRWK=
TE-5 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7iXmdKSzVyPUS1Mlk2QDFizszN NX31dFNTW0GQR1XS
EW-24 NHnoU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;TNFFKUUN3ME20Ok4yPzJ|IN88US=> MVrTRW5ITVJ?
LB647-SCLC NIex[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTqTWM2OD12Nj6yNVU2KM7:TR?= M3y1dXNCVkeHUh?=
NCI-H524 MmPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnLS|FNUUN3ME20Ok44OTh3IN88US=> NI\pcmNUSU6JRWK=
EW-11 NX;FUGlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nFSGlEPTB;NE[uPVM4OyEQvF2= NW\sfZB2W0GQR1XS
KALS-1 NVS0[mdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELkSoVKSzVyPUS3MlIxPjZizszN MWLTRW5ITVJ?
BT-474 MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne3TWM2OD12Nz60NlE3KM7:TR?= M4jUXHNCVkeHUh?=
SK-N-AS M1Hse2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTaTWM2OD12Nz64PFgh|ryP MVjTRW5ITVJ?
HCC2157 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrNbpB6UUN3ME20PE4xPzZizszN MmLoV2FPT0WU
HCC1954 NY\KSpBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTxbZpKSzVyPUS4MlE4ODRizszN MmfwV2FPT0WU
FADU NFvOe2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTR6LkOwN|Eh|ryP NWKwW2xMW0GQR1XS
S-117 NXTFSocyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjmbHJKSzVyPUS4MlM5OTVizszN M4XxS3NCVkeHUh?=
LS-1034 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\0VolKSzVyPUS4MlcxPjdizszN NFnHdIRUSU6JRWK=
CAMA-1 M3nHPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLCTWM2OD12OT61OVQ{KM7:TR?= NUK1SpNvW0GQR1XS
LU-134-A MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml60TWM2OD12OT64NFg2KM7:TR?= NGjWNYRUSU6JRWK=
NCI-H1838 NFvL[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVezeldnUUN3ME20PU45ODh5IN88US=> NXjJNZY1W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]
臨床試験 AP24534 is currently under Phase II clinical trials in treatment with leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Peptide substrate phosphorylation assays with GST-Abl kinase domains The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.

細胞アッセイ: [2]

細胞株 Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
濃度 0-625 nM
反応時間 72 hours
実験の流れ Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat

動物実験: [1]

動物モデル Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
製剤 Dissolved in 25 mM citrate buffer, pH 2.75
投薬量 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
投与方法 Oral gavage once daily

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Ponatinib (AP24534) SDF
分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (56.33 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 3-(2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

カスタマーフィードバック (2)


Click to enlarge
Rating
Source Cancer Cell, 2012, 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck
Method Western blot
Cell Lines RCH-ACV cells
Concentrations 50 nM
Incubation Time 1-24 h
Results Treatment of these cells with a CSK inhibitor (BMS-599626) or a BTK inhibitor (PCI-32765) did not recapitulate the dasatinib/ponatinib phenotype.

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Source , , Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck
Method Cell Proliferation Assay
Cell Lines KatoIII cells
Concentrations 0-0.5 nM
Incubation Time
Results Each of the inhibitors demonstrated a statistically significant lower IC50 in FGFR2-amplified KatoIII cells compared to non-FGFR2-amplified AGS cells at all concentrations tested.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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