Ponatinib (AP24534) 化学構造
分子量: 532.56

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製品説明

  • Compare Bcr-Abl Inhibitors
    Bcr-Abl製品生物活性の比較
  • 研究分野
  • Ponatinib (AP24534)のメカニズム

製品の説明

生物活性

製品説明 Ponatinib (AP24534) は、PI3KγとPI4KIIIβの新しくて強力な阻害剤で、IC50 がそれぞれ16 nM と 19 nMになる。
ターゲット Abl PDGFRα VEGFR2 FGFR1 Src
IC50 0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM [1]
In vitro試験 AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell M1Lmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHNeo5yUUN3ME2wMlAxODByMECzOVkh|ryP MkX3V2FPT0WU
MV-4-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:1b2lEPTB;MD6wNFAxQTV4IN88US=> MkPvV2FPT0WU
MEG-01 M3TUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3CfIxKSzVyPUCuNFAxOTJ6IN88US=> M{Pj[3NCVkeHUh?=
LAMA-84 M3;mUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMECwNVY2KM7:TR?= M3\YNHNCVkeHUh?=
CGTH-W-1 NWCxVmxET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrCTWM2OD1yLkCwNVY6KM7:TR?= M4LDZnNCVkeHUh?=
KASUMI-1 M{XufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHkdVJpUUN3ME2wMlAxOjF5IN88US=> NXv4UHB7W0GQR1XS
BE-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvrTWM2OD1yLkCwNlU6KM7:TR?= MnHsV2FPT0WU
CTV-1 MlzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vzZ2lEPTB;MD6wNFUzOSEQvF2= Ml[0V2FPT0WU
NKM-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfWXHNQUUN3ME2wMlAxPjV3IN88US=> MlezV2FPT0WU
MONO-MAC-6 NVG5bGJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEC4N|ch|ryP MWXTRW5ITVJ?
A204 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEGyNVgh|ryP NHTUXFRUSU6JRWK=
GDM-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPYflhMUUN3ME2wMlAyQDN|IN88US=> MYfTRW5ITVJ?
AN3-CA M4LnSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofhTWM2OD1yLkCxPFc{KM7:TR?= NVHFdY57W0GQR1XS
BL-70 M{j1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPvSXVmUUN3ME2wMlAzOTl7IN88US=> MUnTRW5ITVJ?
Daudi MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[0UlFKSzVyPUCuNFI2OzdizszN NWewbItoW0GQR1XS
KU812 NEPYW4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFizN|VKSzVyPUCuNFI5PDhizszN MXHTRW5ITVJ?
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HuO9 M3K1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j0S2lEPTB;MD6wOVQ1QCEQvF2= NGnCeGlUSU6JRWK=
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SIG-M5 MoHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe3N3dKSzVyPUCuNVM{PyEQvF2= NF\NW4ZUSU6JRWK=
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NCI-H716 MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEe0[WNKSzVyPUCuNVYzPjZizszN M1OyTHNCVkeHUh?=
MPP-89 NXizfJc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn4TWM2OD1yLkG2PVM{KM7:TR?= M2fSdHNCVkeHUh?=
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CTB-1 NX63SlNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH20cG9KSzVyPUCuNVc{OTZizszN NXvFWIJVW0GQR1XS
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NCI-H520 Ml\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn2WJVPUUN3ME2wMlE4PzN{IN88US=> MVTTRW5ITVJ?
CAL-85-1 MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfKWplKSzVyPUCuNVc6OjdizszN M1PLR3NCVkeHUh?=
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NCI-H2087 NULz[IlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMkC0N|kh|ryP MVHTRW5ITVJ?
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CAKI-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz4eHFoUUN3ME2wMlIyPjZ4IN88US=> NXjBS3BWW0GQR1XS
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NALM-6 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OwfGlEPTB;MD6yOVU1OyEQvF2= NUT6ZXNsW0GQR1XS
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KYSE-180 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzH[I5wUUN3ME2wMlI3QDlzIN88US=> NVvXTJN2W0GQR1XS
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HuH-7 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrJToxKSzVyPUCuNlc4PjNizszN MWjTRW5ITVJ?
CAS-1 NVW3VHNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\6cnlKSzVyPUCuNlg{ODNizszN NGHzV4hUSU6JRWK=
KURAMOCHI NWP1fJJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfnNFN{UUN3ME2wMlI5PDF7IN88US=> MV3TRW5ITVJ?
ACHN NUX6OZB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHoSGpDUUN3ME2wMlI6OzJ|IN88US=> M1rIOXNCVkeHUh?=
HGC-27 MmGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDxTWM2OD1yLkK5N|U{KM7:TR?= NETnUVdUSU6JRWK=
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SK-HEP-1 NUH2T|FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLyTWM2OD1yLkOzN|Y5KM7:TR?= NVPsPYpxW0GQR1XS
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BxPC-3 NHHUZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\lbY84UUN3ME2wMlM1QTh7IN88US=> M{\oTXNCVkeHUh?=
BCPAP NUDkSXg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorSTWM2OD1yLkO2NFAyKM7:TR?= MkTzV2FPT0WU
HOP-62 M4jr[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1roXGlEPTB;MD6zOlExPiEQvF2= MlXBV2FPT0WU
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OVCAR-4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTPOG81UUN3ME2wMlQyPTh4IN88US=> MlG0V2FPT0WU
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COLO-678 NYWyTGRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjsTWM2OD1{LkC0NlA4KM7:TR?= MnPWV2FPT0WU
MEL-JUSO NGX6SHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n1dmlEPTB;Mj6wO|g2OSEQvF2= MVnTRW5ITVJ?
HCC38 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv6PFVKSzVyPUKuNFg1OzNizszN MV;TRW5ITVJ?
UACC-62 NVLFd5I3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;SV5JbUUN3ME2yMlA5QDV3IN88US=> MVTTRW5ITVJ?
OAW-42 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jiNGlEPTB;Mj6wPVcyOSEQvF2= MXzTRW5ITVJ?
LB996-RCC NXTaRnJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPNTWM2OD1{LkGzPFE4KM7:TR?= MYrTRW5ITVJ?
COR-L105 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37vbWlEPTB;Mj6xOlM4OyEQvF2= MlvTV2FPT0WU
RCC10RGB NXzIR2V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULoWWhiUUN3ME2yMlE5PTd4IN88US=> NUX4boVCW0GQR1XS
A431 M3TVUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwMUmwNVkh|ryP NXHv[m5sW0GQR1XS
NCI-H292 MnT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIn2TVFKSzVyPUKuNlM6PTFizszN MnviV2FPT0WU
SK-UT-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJwM{OxPFQh|ryP MoqwV2FPT0WU
PANC-08-13 M{PTZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DwVWlEPTB;Mj6zN|I{PSEQvF2= NUnGbot5W0GQR1XS
ST486 NWHKdXJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzTeYtWUUN3ME2yMlQyODR6IN88US=> MUfTRW5ITVJ?
SJSA-1 NXXRWlZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLpTWM2OD1{LkSxNlcyKM7:TR?= NEjt[XFUSU6JRWK=
RKO M1fBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPYUHU1UUN3ME2yMlQzODJ7IN88US=> M1;wSXNCVkeHUh?=
NCI-H1793 NFS0PYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJwNESwNlkh|ryP M{\KeHNCVkeHUh?=
639-V NEW2S|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3ITWM2OD1{LkS1N|gzKM7:TR?= NFXWRnBUSU6JRWK=
ES3 NXy2Om9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJwNEm3N|ch|ryP NXzqWVh2W0GQR1XS
NCI-H1792 NUnqfFlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzWfYNKSzVyPUKuOVY5OjZizszN MVLTRW5ITVJ?
NCI-H1651 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\ufGlEPTB;Mj61PFIyKM7:TR?= MV7TRW5ITVJ?
SN12C M2facGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJwNUi0PFch|ryP NV\2bGFqW0GQR1XS
COLO-679 M4D1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PabmlEPTB;Mj61PFYxPSEQvF2= MULTRW5ITVJ?
U-118-MG NFHWTGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfpNVZEUUN3ME2yMlU5QDd{IN88US=> M{LoWnNCVkeHUh?=
Ramos-2G6-4C10 NHfDcIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF72dnBKSzVyPUKuOlQ5ODdizszN NHzpbIpUSU6JRWK=
HCT-15 NFTx[nhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC2fmxKSzVyPUKuOlg4QTJizszN NV:0ZYRUW0GQR1XS
MDA-MB-157 M{PXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7Nc3JuUUN3ME2yMlcxPzR5IN88US=> NXvOV4hGW0GQR1XS
K5 NF;JNXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjZO|JKSzVyPUKuO|E5PDVizszN NYfYflQ{W0GQR1XS
MKN45 M3vDfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n0N2lEPTB;Mj63N|M3PiEQvF2= NXzYclkxW0GQR1XS
DMS-273 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJwN{W2N|Ih|ryP NYLkd|hrW0GQR1XS
C8166 NGPROo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3xVIgzUUN3ME2yMlc5PTF|IN88US=> NFHSRWZUSU6JRWK=
Calu-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlKwTWM2OD1{Lke4PVY6KM7:TR?= NVHLdHRXW0GQR1XS
SNB75 NHLGT2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDZTWM2OD1{Lki4OVM2KM7:TR?= NF3yOYhUSU6JRWK=
BFTC-905 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJwOUCxPVEh|ryP MoPwV2FPT0WU
C-4-II NHO3dmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXYTWM2OD1{LkmxN|U{KM7:TR?= NGDwUWtUSU6JRWK=
MS-1 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXOOIZKSzVyPUKuPVY4PjlizszN MlzmV2FPT0WU
A375 M{PUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2GxTmlEPTB;Mz6wPFE5PCEQvF2= MX7TRW5ITVJ?
KYSE-70 NIrpPFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{OxbmlEPTB;Mz6wPFg5OiEQvF2= MWnTRW5ITVJ?
KYSE-510 NF72OZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHWVnNKSzVyPUOuNVA6QTVizszN MmHKV2FPT0WU
LN-405 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ToS2lEPTB;Mz6xN|UyQCEQvF2= MYTTRW5ITVJ?
BOKU MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\BZWdKSzVyPUOuNVQzPTZizszN M2LYWnNCVkeHUh?=
TE-10 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVr1dIVbUUN3ME2zMlE4OzZ{IN88US=> MYfTRW5ITVJ?
MKN1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\6TWM2OD1|LkG4OFg{KM7:TR?= NIn2cotUSU6JRWK=
M059J NGC1b4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzRTZJKSzVyPUOuNlAyPzNizszN MlnOV2FPT0WU
GOTO MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi2Vo5nUUN3ME2zMlIzODN7IN88US=> NVfQS|EzW0GQR1XS
DK-MG M4fEUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi3WlNKSzVyPUOuNlU6PzZizszN M2jFRXNCVkeHUh?=
NCI-H727 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XncWlEPTB;Mz6yOlU5KM7:TR?= NVnYXI02W0GQR1XS
NB12 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj4TWM2OD1|LkOzNlI1KM7:TR?= MkjCV2FPT0WU
DOK NGTHcVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLoTWM2OD1|LkO2NVg3KM7:TR?= M3z4enNCVkeHUh?=
KYSE-410 NXfmPZBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNwM{[yPFch|ryP NILnfGxUSU6JRWK=
AM-38 MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNwM{iwOVEh|ryP NXnBdIRJW0GQR1XS
GR-ST NEHIU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfnTWM2OD1|LkS1O|MzKM7:TR?= M3;hSXNCVkeHUh?=
D-247MG NInZV5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojRTWM2OD1|LkS4NlY{KM7:TR?= NVLm[ngxW0GQR1XS
TE-8 M3L4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTwRnFKSzVyPUOuOFk{OzNizszN NFHXUHFUSU6JRWK=
LS-411N NH\hZlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTNwNEm2PVIh|ryP M{f5VnNCVkeHUh?=
SK-MES-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Xs[2lEPTB;Mz61OlQ{OyEQvF2= NGm0V3dUSU6JRWK=
SF295 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTNwNkG1OVIh|ryP NYflRWJpW0GQR1XS
SK-MEL-30 M1i3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zqR2lEPTB;Mz62OVkzOSEQvF2= NHXiT5VUSU6JRWK=
LB2241-RCC MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTNwNk[yOkDPxE1? M1LuT3NCVkeHUh?=
PC-14 M2HEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHywb5pKSzVyPUOuOlY1OzdizszN NHrJXodUSU6JRWK=
EW-7 M{WwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXNW5BKSzVyPUOuOlc3QTNizszN MlLUV2FPT0WU
NMC-G1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTNwN{G4N|ch|ryP MUjTRW5ITVJ?
TE-441-T M{fUXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTNwN{OwNlgh|ryP M4G4UHNCVkeHUh?=
NCI-H1618 MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTNwOEG4O|Uh|ryP M{fFNHNCVkeHUh?=
PANC-03-27 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTNwOEG5NVYh|ryP NXnKcWQyW0GQR1XS
NCI-H2228 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fJRmlEPTB;Mz64N|EzPiEQvF2= MV;TRW5ITVJ?
CAPAN-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTNwOEewNFkh|ryP Mnu5V2FPT0WU
KLE NHHZWG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTNwOUC2O{DPxE1? NHjWSGpUSU6JRWK=
Becker NWrCeVJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzTXYdKUUN3ME2zMlkzQDR7IN88US=> MlT1V2FPT0WU
SK-PN-DW NI\0bo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvJTWM2OD12LkC3PVc1KM7:TR?= MYPTRW5ITVJ?
Hs-578-T NUXGUo9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PH[mlEPTB;ND6wPFMxPiEQvF2= NIjnO2RUSU6JRWK=
RS4-11 MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTRwMUGyOVUh|ryP M{LzXnNCVkeHUh?=
D-502MG NUnvR28xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRwMU[5PVch|ryP MojvV2FPT0WU
GI-1 NWG5VJJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnOTWM2OD12LkK4Nlk6KM7:TR?= NGDIVJdUSU6JRWK=
NCI-H209 NFTSTVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[4TWM2OD12LkOzO|gh|ryP M1nEeHNCVkeHUh?=
SK-OV-3 M2LFe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXqVWNKSzVyPUSuOFgyPDlizszN NHPtNXpUSU6JRWK=
LOUCY MoLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTRwNEi0N|Ih|ryP MoLBV2FPT0WU
NCI-H69 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\FTWM2OD12LkWxO|k{KM7:TR?= NGPxRmVUSU6JRWK=
SCC-9 M4jRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTRwNUOxO|Ih|ryP MVnTRW5ITVJ?
NCI-H526 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULmNGc1UUN3ME20MlU6Ojl|IN88US=> NHTvc3RUSU6JRWK=
NCI-H2170 NGTlR|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7yeWtmUUN3ME20MlY3PzdzIN88US=> MX;TRW5ITVJ?
SR MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXFOZJKSzVyPUSuO|AxPDhizszN M1G3bnNCVkeHUh?=
CMK MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz4TWM2OD12LkeyNVAyKM7:TR?= MkjMV2FPT0WU
COLO-829 M1rUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTRwN{ewOFMh|ryP Mnu3V2FPT0WU
HuO-3N1 MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7CfZRKSzVyPUSuPFMzQDFizszN NVvNUIxbW0GQR1XS
5637 M2nsWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\ZOGlEPTB;ND65NFQ5PyEQvF2= M33rWHNCVkeHUh?=
A253 MknMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\QTWM2OD12Lkm3O|A5KM7:TR?= NUT5NHBSW0GQR1XS
NB10 NIPYcYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe5bmRKSzVyPUWuNFc1QTdizszN M4\pb3NCVkeHUh?=
SF539 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3xTWM2OD13LkC5PVU6KM7:TR?= MWDTRW5ITVJ?
HAL-01 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\FS4J2UUN3ME21MlE1PjR3IN88US=> M3TuZnNCVkeHUh?=
MHH-ES-1 NUPDSmtTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTVwMU[5NlUh|ryP M3z5UnNCVkeHUh?=
DEL MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHiTWM2OD13LkK3OVgzKM7:TR?= NETTZlBUSU6JRWK=
NCI-H1299 NIfLeWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7WVmZIUUN3ME21MlM2ODB5IN88US=> MkHmV2FPT0WU
ChaGo-K-1 M3;Kbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFn2cHBKSzVyPUWuN|UyODdizszN MkPvV2FPT0WU
HMV-II NV\3UZppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDJTWM2OD13LkO5OFMh|ryP NID3RnZUSU6JRWK=
NB69 NETDOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrEcYI5UUN3ME21MlM6PjNzIN88US=> NUjDWXlDW0GQR1XS
NCI-H1882 NXfxTWNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTKTWM2OD13LkSzN|Y1KM7:TR?= M3nNXXNCVkeHUh?=
SNU-475 MmDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;FOWlEPTB;NT60O|E4OSEQvF2= M1rnfXNCVkeHUh?=
RXF393 M{jBU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFn1[4NKSzVyPUWuOFg1QTRizszN M1\y[3NCVkeHUh?=
CAL-51 M3LrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTBTWM2OD13Lk[yPFU{KM7:TR?= NIjjOlFUSU6JRWK=
SW1573 MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLVTWM2OD13Lk[zOVM1KM7:TR?= M2q4eHNCVkeHUh?=
GCT MoPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTVwN{W5Nlkh|ryP M3TmfnNCVkeHUh?=
COR-L88 NXnZOXN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnQVo83UUN3ME21Mlc3QDR4IN88US=> MnK0V2FPT0WU
MDA-MB-134-VI MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTVwOEe1N|Yh|ryP NH3rco5USU6JRWK=
NB5 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q2bmlEPTB;NT65NlQ1KM7:TR?= M1jzTnNCVkeHUh?=
GMS-10 NHfJOohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XxNGlEPTB;NT65Olg3OSEQvF2= MV\TRW5ITVJ?
CHP-212 NYeyfpZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXsW45rUUN3ME22MlQ5OjZ5IN88US=> MXTTRW5ITVJ?
TE-11 M1jST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTZwNUWxPFIh|ryP M3HZ[3NCVkeHUh?=
SW962 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zqRWlEPTB;Nj62OVc4PCEQvF2= MUfTRW5ITVJ?
MZ2-MEL M4\2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTZwOEKwNVEh|ryP NFK2SodUSU6JRWK=
C-33-A NFO2PHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfL[nBKSzVyPU[uPVE3QDhizszN MoDoV2FPT0WU
IGR-1 NHTlNYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHJWZRKSzVyPU[uPVc5OjZizszN MW\TRW5ITVJ?
MOLT-4 M{fVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojmTWM2OD15LkG1OFA3KM7:TR?= Mk\1V2FPT0WU
NCI-H1650 M2\ySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorTTWM2OD15LkK3NFQ3KM7:TR?= NUnR[2lLW0GQR1XS
AsPC-1 NVHUT|dkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL4TWM2OD15LkK4OlA2KM7:TR?= NUW0cGRpW0GQR1XS
SNU-C2B MkHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;BfVRKSzVyPUeuNlk2PzFizszN Mn30V2FPT0WU
MKN7 NHvjUmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\oS2lEPTB;Nz6zO|I{PSEQvF2= MlPWV2FPT0WU
SW620 NXf1dY05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELNW|BKSzVyPUeuN|gzODVizszN NIPVSFdUSU6JRWK=
SK-MEL-28 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTdwNEC3PVgh|ryP MVvTRW5ITVJ?
TE-6 M3;DWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfNbG9IUUN3ME23MlQ1QTB6IN88US=> NYTORVRJW0GQR1XS
D-263MG MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3zUoRKSzVyPUeuOFU4PjJizszN MXnTRW5ITVJ?
NCI-H1355 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly1TWM2OD15Lke3NFI6KM7:TR?= MWjTRW5ITVJ?
DSH1 MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDmTWM2OD15Lke5O|YzKM7:TR?= Ml63V2FPT0WU
NCI-H460 M{C3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRThwMEC2PVQh|ryP NH\jeotUSU6JRWK=
NCI-H1563 M4P2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRThwMEe1NFgh|ryP M1fUdnNCVkeHUh?=
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U251 NHjlTXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Dj[WlEPTB;MkSuNFY3QCEQvF2= NGnLOYRUSU6JRWK=
LoVo NIfERolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P1c2lEPTB;MkSuPVI5OiEQvF2= MojMV2FPT0WU
GCIY MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILVbo5KSzVyPUK1MlI5PzdizszN NVLHZWVkW0GQR1XS
NUGC-3 M2\tWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL6TWM2OD1{NT6zN|E3KM7:TR?= NF20ZYxUSU6JRWK=
LNCaP-Clone-FGC NWnKb2liT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLiTWM2OD1{NT6zOFk5KM7:TR?= MUjTRW5ITVJ?
PA-1 NFnuRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LOfGlEPTB;MkWuOlg{OyEQvF2= M3fmdXNCVkeHUh?=
OE33 NEPvdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ3Lk[4OVMh|ryP NVuxVWtQW0GQR1XS
HT-29 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jaNWlEPTB;MkWuO|g4QSEQvF2= MlzZV2FPT0WU
RCM-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPh[5dWUUN3ME2yOU46PjV4IN88US=> MUjTRW5ITVJ?
NCI-H1522 NFrNNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ3Lkm5NVEh|ryP NH65[41USU6JRWK=
LB373-MEL-D MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfse5RzUUN3ME2yOk4yPzB6IN88US=> MUTTRW5ITVJ?
NCI-H1436 M{nCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\BOlU2UUN3ME2yOk4zPzN6IN88US=> MYHTRW5ITVJ?
COLO-824 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDWTWM2OD1{Nj60NFAzKM7:TR?= NIi3RohUSU6JRWK=
CP50-MEL-B NYTpeXYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\OR2lEPTB;Mk[uOVY4PSEQvF2= NUnjRWNjW0GQR1XS
EGI-1 M1PMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLLTWM2OD1{Nz6yOlk5KM7:TR?= MoL3V2FPT0WU
LAN-6 NIK3TIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{P1VGlEPTB;MkeuN|U6QCEQvF2= MXrTRW5ITVJ?
GAK NFrnNHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[2TJpiUUN3ME2yO{41OjJ3IN88US=> NFjjSIpUSU6JRWK=
MDA-MB-175-VII NH7nVFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVW2S|d4UUN3ME2yO{42ODV|IN88US=> NYPrWlZNW0GQR1XS
JVM-2 M2[xeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L1NGlEPTB;MkeuOlYzOiEQvF2= MVnTRW5ITVJ?
UACC-257 NIL1eIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJ5Lk[4O|gh|ryP MmrXV2FPT0WU
SW1783 NFO2eG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzRNHBYUUN3ME2yO{44Pzh|IN88US=> M3OwfnNCVkeHUh?=
HT-3 MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfxenVKSzVyPUK4MlIyPjZizszN NF7CU4dUSU6JRWK=
RL M1T2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYKzPIxRUUN3ME2yPE42QTFzIN88US=> NEm3NmJUSU6JRWK=
TK10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJ6Lk[1N|Uh|ryP M13R[3NCVkeHUh?=
HT55 NVfOb3d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TMfGlEPTB;MkmuNFU3PSEQvF2= NYLrV2pHW0GQR1XS
BT-20 NUnzSFFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTJ7LkC1PFYh|ryP NFzNfGZUSU6JRWK=
TGBC24TKB MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJ7LkG4N|Eh|ryP M{XReHNCVkeHUh?=
HSC-2 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7OVVNMUUN3ME2yPU4{ODBzIN88US=> NXzrUlNGW0GQR1XS
COLO-205 NE\kTWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJ7LkO5OFQh|ryP NHnYUGJUSU6JRWK=
GT3TKB MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHQc3VKSzVyPUK5MlY5PzdizszN MVvTRW5ITVJ?
T47D NIj1TG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTSTWM2OD1{OT64OVgzKM7:TR?= NY\GS206W0GQR1XS
OMC-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vTOGlEPTB;M{CuNVkyQSEQvF2= MnTZV2FPT0WU
PFSK-1 NXfH[HNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnjeFRQUUN3ME2zNU4zPjV7IN88US=> NIjiNnRUSU6JRWK=
JEG-3 NGLGPWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TlOGlEPTB;M{GuN|U3OSEQvF2= NHPn[5BUSU6JRWK=
RD MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTNzLkWxNVUh|ryP M1z6SHNCVkeHUh?=
NCI-H64 NYHwWXJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTaN4xKSzVyPUOyMlQyPzlizszN NGjp[oxUSU6JRWK=
DMS-114 NG\oWWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUCyW291UUN3ME2zNk41OTh{IN88US=> NUDXWo9kW0GQR1XS
NCI-H661 NWSyOJhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zK[2lEPTB;M{KuOlUxOSEQvF2= M3TTSXNCVkeHUh?=
CAL-148 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;TUoRKSzVyPUOyMlY3PjVizszN NV7INYJWW0GQR1XS
HuP-T3 MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Cx[WlEPTB;M{KuPVM{QCEQvF2= NXHuNG46W0GQR1XS
ES4 NHLDRnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrsV5NKSzVyPUOzMlE4ODVizszN NGHtNYJUSU6JRWK=
Ca9-22 M3Lk[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\hTWM2OD1|Mz60OlAyKM7:TR?= MnXSV2FPT0WU
LP-1 MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DGO2lEPTB;M{SuNFkh|ryP Mnr5V2FPT0WU
AU565 M2j5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPWeWR7UUN3ME2zOE42ODZ7IN88US=> M1rMVXNCVkeHUh?=
MDA-MB-453 NWnRbHYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjC[nlKSzVyPUO1MlE1OjZizszN MmTqV2FPT0WU
SNU-C1 NFT4c5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq0Z29lUUN3ME2zOU4yPzFizszN MnfjV2FPT0WU
SW13 NUP4cnlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDWTWM2OD1|NT60NFc3KM7:TR?= NEXOPZZUSU6JRWK=
NCI-H2122 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnITWM2OD1|NT61OVk5KM7:TR?= MVrTRW5ITVJ?
NCI-H1395 NGLNOmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy5eYZEUUN3ME2zOU43PjlzIN88US=> Ml7iV2FPT0WU
J-RT3-T3-5 M1fRc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7sNpdKSzVyPUO2MlAzQTRizszN NELZUmtUSU6JRWK=
COR-L279 NXHDcm1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jw[WlEPTB;M{[uNVk5OSEQvF2= NX24dI5HW0GQR1XS
ATN-1 NIrYd4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4iwZWlEPTB;M{[uPFUyPiEQvF2= NUjYR4xTW0GQR1XS
HCC2998 NV\jeW5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPidplKSzVyPUO2Mlg2PzFizszN MkLUV2FPT0WU
UM-UC-3 Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vlbGlEPTB;M{[uPFY4PSEQvF2= NWfob|VpW0GQR1XS
DV-90 NH:0V25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTN4LkmwOlch|ryP NUO1Unk5W0GQR1XS
ES8 MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K3S2lEPTB;M{[uPVMyQCEQvF2= MUjTRW5ITVJ?
YAPC NGrWSFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr1WHRKSzVyPUO2Mlk3PTRizszN NUXoSplSW0GQR1XS
HCC1599 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPHdIpDUUN3ME2zO{4yPjF6IN88US=> NUD3bHBFW0GQR1XS
UMC-11 M1HESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHaPGZKSzVyPUO3MlI2ODNizszN NFXkOZlUSU6JRWK=
THP-1 NGHBOXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4T4cWlEPTB;M{euNlg3QCEQvF2= Mnz4V2FPT0WU
OCUB-M M13qVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTN5LkK4PVEh|ryP MXvTRW5ITVJ?
NCI-H1693 NYHPbHczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHkTWM2OD1|Nz6zNlM{KM7:TR?= MoPMV2FPT0WU
NCI-H345 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG1WI1KSzVyPUO3MlM3OjRizszN MmG4V2FPT0WU
COLO-800 NXvqN3h5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3qxWWlEPTB;M{euOVY4KM7:TR?= NELBemJUSU6JRWK=
COLO-320-HSR M{\vbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlKxTWM2OD1|OD6zOFkzKM7:TR?= Mnj4V2FPT0WU
NCI-H596 MljXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzkTWM2OD1|OD60OFg6KM7:TR?= M{PK[XNCVkeHUh?=
NCI-H187 M1G1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTN6LkezOFQh|ryP NXjGdYZLW0GQR1XS
ECC4 NUO2W3VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\NN5BKSzVyPUO5MlA5OTRizszN NELOUmZUSU6JRWK=
KP-4 MlXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTN7LkGyN|Uh|ryP NWjKUppMW0GQR1XS
NCI-H2227 M1nCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TUd2lEPTB;M{muN|k1QSEQvF2= MXzTRW5ITVJ?
22RV1 M3fMXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjNPJZKSzVyPUO5Mlg{QThizszN NFnaVnBUSU6JRWK=
SAS M1HpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vTSWlEPTB;NECuNFk3KM7:TR?= NXHkfmhWW0GQR1XS
PANC-10-05 M{TBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[0RmxKSzVyPUSwMlE5OjhizszN NYDMbFJzW0GQR1XS
MDA-MB-468 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LncWlEPTB;NECuOVM1PiEQvF2= M2ThZ3NCVkeHUh?=
RPMI-7951 M2nMTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j6ZmlEPTB;NEGuNlA4PSEQvF2= NXS4V|dwW0GQR1XS
BB49-HNC NWf1TI9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLIO5VKSzVyPUSxMlIyPzlizszN NFTL[JpUSU6JRWK=
23132-87 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTRzLkK3N|Ih|ryP NUTRWHFoW0GQR1XS
HCC1569 MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjHUZh3UUN3ME20NU4zQDh3IN88US=> NITseYhUSU6JRWK=
CP66-MEL NH;afGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHm4eZJKSzVyPUSyMlE5QDZizszN NF3PXopUSU6JRWK=
K-562 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDiTWM2OD12Mj6yPFU1KM7:TR?= NYnieYZ3W0GQR1XS
OCI-AML2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7yW4pKSzVyPUSyMlg6PzRizszN MlK4V2FPT0WU
SW756 M{H2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\6PXVKSzVyPUSzMlA{QDhizszN MXnTRW5ITVJ?
M14 M1;iS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHMTWM2OD12Mz6zNVg6KM7:TR?= NWPHWHJnW0GQR1XS
NCI-H1623 NHrhSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTR|LkS2OEDPxE1? MXzTRW5ITVJ?
KNS-81-FD NUnXfmZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTR|Lke2NkDPxE1? MV7TRW5ITVJ?
TGBC1TKB NULCSZRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnSwTWM2OD12Mz65NFk6KM7:TR?= NVezTlI{W0GQR1XS
RERF-LC-MS MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrLTWM2OD12Mz65NlgyKM7:TR?= MnnqV2FPT0WU
PC-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj2TWM2OD12ND60N|Q4KM7:TR?= MX7TRW5ITVJ?
HuP-T4 NFfwR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\2TWM2OD12ND60OFc1KM7:TR?= M1PDUnNCVkeHUh?=
NCI-H510A NFK2TYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFuyNWFKSzVyPUS0MlcxQCEQvF2= M3;hfHNCVkeHUh?=
LB2518-MEL MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP3c2Z5UUN3ME20OE44QTN5IN88US=> NUPlSXlKW0GQR1XS
TE-5 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLwNVZKSzVyPUS1Mlk2QDFizszN MojXV2FPT0WU
EW-24 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\NN2lEPTB;NE[uNVczOyEQvF2= NV7PcYlmW0GQR1XS
LB647-SCLC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XxNGlEPTB;NE[uNlE2PSEQvF2= M{LkR3NCVkeHUh?=
NCI-H524 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nMUmlEPTB;NE[uO|E5PSEQvF2= NXrkN2ZPW0GQR1XS
EW-11 NYr6R3VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LoOGlEPTB;NE[uPVM4OyEQvF2= MlXMV2FPT0WU
KALS-1 NYjae2VnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PQN2lEPTB;NEeuNlA3PiEQvF2= NYTnTWlSW0GQR1XS
BT-474 MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVewSoN4UUN3ME20O{41OjF4IN88US=> NVrUeVlzW0GQR1XS
SK-N-AS NYnNeld3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTR5Lki4PEDPxE1? MWXTRW5ITVJ?
HCC2157 M2nF[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDqeXRDUUN3ME20PE4xPzZizszN M1\CPHNCVkeHUh?=
HCC1954 NHr2d4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[yPHlKSzVyPUS4MlE4ODRizszN MXvTRW5ITVJ?
FADU MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTR6LkOwN|Eh|ryP NFnzNXFUSU6JRWK=
S-117 MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TkWWlEPTB;NEiuN|gyPSEQvF2= M{m1[XNCVkeHUh?=
LS-1034 NXfDVIxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XNOmlEPTB;NEiuO|A3PyEQvF2= NFfmO5JUSU6JRWK=
CAMA-1 Mm\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr1XlJ2UUN3ME20PU42PTR|IN88US=> Mme2V2FPT0WU
LU-134-A MoS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\kTWM2OD12OT64NFg2KM7:TR?= NYfrbWY3W0GQR1XS
NCI-H1838 NGH0W|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTR7LkiwPFch|ryP NGTHbndUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]
臨床試験 AP24534 is currently under Phase II clinical trials in treatment with leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Peptide substrate phosphorylation assays with GST-Abl kinase domains The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.

細胞アッセイ: [2]

細胞株 Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
濃度 0-625 nM
反応時間 72 hours
実験の流れ Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat

動物実験: [1]

動物モデル Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
製剤 Dissolved in 25 mM citrate buffer, pH 2.75
投薬量 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
投与方法 Oral gavage once daily

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Ponatinib (AP24534) SDF
分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (56.33 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 3-(2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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Frequently Asked Questions

  • Question 1
    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

    Answer: Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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