Ponatinib (AP24534)

Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。

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Ponatinib (AP24534) 化学構造
分子量: 532.56

高品質保証

カスタマーフィードバック(3)

MSDS

製品説明

  • Compare Bcr-Abl Inhibitors
    Bcr-Abl製品生物活性の比較
  • 研究分野
  • Ponatinib (AP24534)のメカニズム

製品の説明

生物活性

製品説明 Ponatinib (AP24534)は一種の新たで、有効な多ターゲット阻害剤で、無細胞試験でAbl、PDGFRα、VEGFR2、FGFR1とSrcに作用する時のIC50値が0.37 nM、1.1 nM、1.5 nM、2.2 nMと5.4 nMにそれぞれ分かれることです。
ターゲット Abl PDGFRα VEGFR2 FGFR1 Src
IC50 0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM [1]
In vitro試験 AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HSeGlEPTB;MD6wNFAxODByM{W5JO69VQ>? NX;Q[IxCW0GQR1XS
MV-4-11 NFPDVnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3qPGJKSzVyPUCuNFAxODl3NjFOwG0> NEjxOI9USU6JRWK=
MEG-01 M4nTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEiySIxKSzVyPUCuNFAxOTJ6IN88US=> NX[4[2JXW0GQR1XS
LAMA-84 NFPWR3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIiyemNKSzVyPUCuNFAxOTZ3IN88US=> NITl[|hUSU6JRWK=
CGTH-W-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHmw[oZKSzVyPUCuNFAyPjlizszN MXjTRW5ITVJ?
KASUMI-1 M4j5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\zTWM2OD1yLkCwNlE4KM7:TR?= NFTXVldUSU6JRWK=
BE-13 NY\HbHNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17JVGlEPTB;MD6wNFI2QSEQvF2= MX;TRW5ITVJ?
CTV-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHrdolFUUN3ME2wMlAxPTJzIN88US=> NUfEOFZpW0GQR1XS
NKM-1 NYLOOWpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHwTWM2OD1yLkCwOlU2KM7:TR?= NIfYSFRUSU6JRWK=
MONO-MAC-6 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEC4N|ch|ryP M174OnNCVkeHUh?=
A204 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33pcGlEPTB;MD6wNVIyQCEQvF2= NYnHSW9yW0GQR1XS
GDM-1 NXqwcY0yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDWc5BKSzVyPUCuNFE5OzNizszN NFHHXnBUSU6JRWK=
AN3-CA NUnGbJZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjmS21JUUN3ME2wMlAyQDd|IN88US=> Mon2V2FPT0WU
BL-70 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M375V2lEPTB;MD6wNlE6QSEQvF2= NGC3fVlUSU6JRWK=
Daudi MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEK1N|ch|ryP MnvOV2FPT0WU
KU812 NUC5UW1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLBVJNTUUN3ME2wMlAzQDR6IN88US=> MX;TRW5ITVJ?
KG-1 M{G1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEOyPVQh|ryP NET0OmhUSU6JRWK=
DOHH-2 NF7E[XBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELhW4VKSzVyPUCuNFQ5ODNizszN MWfTRW5ITVJ?
HuO9 M{GzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:2TWM2OD1yLkC1OFQ5KM7:TR?= NITLU4hUSU6JRWK=
EB2 NXjNNXVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTsTWM2OD1yLkC1OVc3KM7:TR?= MVXTRW5ITVJ?
G-402 M{OzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwME[zOFEh|ryP NE\3TnFUSU6JRWK=
SU-DHL-1 M4LIUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e0dWlEPTB;MD6wOlM4QSEQvF2= NVPLTVlLW0GQR1XS
NCI-H719 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrOPYFKSzVyPUCuNFc5QDhizszN MmDkV2FPT0WU
MLMA M2raW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PpeGlEPTB;MD6wPVA3KM7:TR?= NGLxeFlUSU6JRWK=
KM12 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMEm3N|ch|ryP M2Ptb3NCVkeHUh?=
SUP-T1 M1;V[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPZTWM2OD1yLkC5PVgzKM7:TR?= MlHPV2FPT0WU
MZ1-PC NF7scJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPXV3RjUUN3ME2wMlEyOzN4IN88US=> MkSyV2FPT0WU
MFE-296 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLwOnhKSzVyPUCuNVE5OzlizszN NVe4PIE6W0GQR1XS
ALL-PO NVv6OIxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3QbotKSzVyPUCuNVI1PDNizszN NFW2T4xUSU6JRWK=
GB-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHHN4xiUUN3ME2wMlEzPTF{IN88US=> M2rMOXNCVkeHUh?=
SIG-M5 NH\n[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMUOzO{DPxE1? NVfJdm05W0GQR1XS
P30-OHK MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrSRWY5UUN3ME2wMlE2Pjd{IN88US=> NF3UN5lUSU6JRWK=
NCI-H716 MlvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17rbGlEPTB;MD6xOlI3PiEQvF2= MXnTRW5ITVJ?
MPP-89 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnUZlZKSzVyPUCuNVY6OzNizszN M1;0O3NCVkeHUh?=
SF126 NHq0SWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;4fow{UUN3ME2wMlE4ODZ|IN88US=> NWTwfIxYW0GQR1XS
CTB-1 NU[2N4EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nQb2lEPTB;MD6xO|MyPiEQvF2= MV3TRW5ITVJ?
CA46 MlXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HZO2lEPTB;MD6xO|Q5QSEQvF2= MX;TRW5ITVJ?
NCI-H520 M4foNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fY[2lEPTB;MD6xO|c{OiEQvF2= M2\rc3NCVkeHUh?=
CAL-85-1 M2jIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWwOll[UUN3ME2wMlE4QTJ5IN88US=> M1TZenNCVkeHUh?=
NCI-H2342 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljITWM2OD1yLkG4OVc4KM7:TR?= NInTfZdUSU6JRWK=
697 MonNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLlOpZDUUN3ME2wMlE5QDdzIN88US=> NFHUVWRUSU6JRWK=
NY MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXlZZRKSzVyPUCuNVkzQDdizszN MkD2V2FPT0WU
T98G NXzBZ2FxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzKZoNKSzVyPUCuNVk{OThizszN MUXTRW5ITVJ?
NCI-H1703 M4LUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq4Z25KSzVyPUCuNVk3OTVizszN MkLtV2FPT0WU
NCI-H2087 NWfK[JBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G2fWlEPTB;MD6yNFQ{QSEQvF2= Mlq5V2FPT0WU
PF-382 NH\4TVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XvN2lEPTB;MD6yNFg4OyEQvF2= M3nsOnNCVkeHUh?=
HCT-116 NIntd|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMkGwOlkh|ryP MYDTRW5ITVJ?
CAKI-1 M1v1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4m0NmlEPTB;MD6yNVY3PiEQvF2= M{i5b3NCVkeHUh?=
CCF-STTG1 NHvlSYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrXVllKSzVyPUCuNlI1PzVizszN NX3IOod{W0GQR1XS
D-392MG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkezTWM2OD1yLkKzNVc4KM7:TR?= MVTTRW5ITVJ?
RT-112 NGjMeZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWWyboVKUUN3ME2wMlI{Pzl3IN88US=> M2HnXnNCVkeHUh?=
MES-SA NWjxb492T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rxbGlEPTB;MD6yOFE5PyEQvF2= M3jWfHNCVkeHUh?=
LC-2-ad M1iwVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33zT2lEPTB;MD6yOFI3PSEQvF2= MW\TRW5ITVJ?
NOS-1 NEjk[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;TRodrUUN3ME2wMlI1OzZ5IN88US=> M{jxUHNCVkeHUh?=
NALM-6 MnLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq4TWM2OD1yLkK1OVQ{KM7:TR?= MkjsV2FPT0WU
TE-15 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLpTWM2OD1yLkK2NFkyKM7:TR?= NFHSSFdUSU6JRWK=
786-0 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMk[yNlgh|ryP MlvwV2FPT0WU
IST-MES1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMk[4Nlkh|ryP MYLTRW5ITVJ?
KYSE-180 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LpdGlEPTB;MD6yOlg6OSEQvF2= MVXTRW5ITVJ?
YT NHzEcnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7hTWM2OD1yLkK2PVc1KM7:TR?= NFv2fZNUSU6JRWK=
A427 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXaeXVKSzVyPUCuNlczPjRizszN MUjTRW5ITVJ?
KYSE-450 MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjtTWM2OD1yLkK3N|I6KM7:TR?= NIHhW4tUSU6JRWK=
HuH-7 NWjn[mFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETzXWtKSzVyPUCuNlc4PjNizszN MUjTRW5ITVJ?
CAS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFy2VG5KSzVyPUCuNlg{ODNizszN NXrEWIljW0GQR1XS
KURAMOCHI MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13IbWlEPTB;MD6yPFQyQSEQvF2= NILlZXdUSU6JRWK=
ACHN NV\QWGR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTwTWM2OD1yLkK5N|I{KM7:TR?= MV;TRW5ITVJ?
HGC-27 NUH5fnE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP2UXBxUUN3ME2wMlI6OzV|IN88US=> MVfTRW5ITVJ?
A172 NF\hU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T5TGlEPTB;MD6yPVU4PyEQvF2= NFXaWmxUSU6JRWK=
SNU-449 NFG0OXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{m0V2lEPTB;MD6yPVk3PCEQvF2= MUfTRW5ITVJ?
SW982 NUflTmxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHtTWM2OD1yLkK5PVc5KM7:TR?= MX;TRW5ITVJ?
EFO-21 M4P5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW3U|h[UUN3ME2wMlMxPDFzIN88US=> M2P0THNCVkeHUh?=
NCI-H2030 NYHqcZBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LxSWlEPTB;MD6zNVE3PCEQvF2= Mn;rV2FPT0WU
HT-144 NFTwNmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwM{GyPEDPxE1? M4D2eHNCVkeHUh?=
MFE-280 NU\VcGl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXC[49JUUN3ME2wMlMyPDV|IN88US=> NYX5cJo3W0GQR1XS
SK-LU-1 M4PxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TwdWlEPTB;MD6zNVQ3PiEQvF2= MkfuV2FPT0WU
NCI-H2052 NIS0[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3oTWM2OD1yLkOxOFg1KM7:TR?= NVPkVFllW0GQR1XS
SK-HEP-1 NWjOZnRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfVWpJKSzVyPUCuN|M{PjhizszN NF[wOIxUSU6JRWK=
QIMR-WIL NWDMT|doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XRcmlEPTB;MD6zN|QzPCEQvF2= M4mxPXNCVkeHUh?=
A2780 M{LoTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3WTWM2OD1yLkO0N|A1KM7:TR?= Mn\DV2FPT0WU
ACN MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnydWVKSzVyPUCuN|Q5PzNizszN MkDLV2FPT0WU
BxPC-3 NVixeZlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jBU2lEPTB;MD6zOFk5QSEQvF2= NVq3fYtlW0GQR1XS
BCPAP M1jwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrHTWM2OD1yLkO2NFAyKM7:TR?= NEXG[|BUSU6JRWK=
HOP-62 NIjWOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvaPGVKSzVyPUCuN|YyODZizszN MUnTRW5ITVJ?
SW1710 NIX2O5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnqxTWM2OD1yLkO2OFU2KM7:TR?= NX;UfHlTW0GQR1XS
OPM-2 NHvZTFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPyTWM2OD1yLkO2OFc{KM7:TR?= NXm4PHRXW0GQR1XS
DBTRG-05MG NYL3Z4hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mny2TWM2OD1yLkO4NFU1KM7:TR?= Mo[3V2FPT0WU
SK-MEL-24 NV\UeYo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\EU4lTUUN3ME2wMlM6PzlzIN88US=> MUnTRW5ITVJ?
8305C NU\aO5R6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTGenpKSzVyPUCuN|k4QTNizszN MkWxV2FPT0WU
OVCAR-4 MnPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHmTWM2OD1yLkSxOVg3KM7:TR?= MkjRV2FPT0WU
HLE NYnXdIJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwNEG4OkDPxE1? M1r1fXNCVkeHUh?=
NCI-H747 NHvv[WlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LsW2lEPTB;MD60NlE{PyEQvF2= M4LCTHNCVkeHUh?=
SW780 MknXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwNEKzOFYh|ryP M3HUd3NCVkeHUh?=
KYSE-150 MlHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnpNmZKSzVyPUCuOFI1OTVizszN Mlu4V2FPT0WU
H4 Ml[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwNEK0OVEh|ryP NXPGT|BuW0GQR1XS
SW1088 MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkWwTWM2OD1yLkS0N|kh|ryP MVrTRW5ITVJ?
SF268 Mli0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P2T2lEPTB;MD60OFg3KM7:TR?= M2LGVHNCVkeHUh?=
RT4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoryTWM2OD1yLkS1NVEyKM7:TR?= MmHXV2FPT0WU
NCI-H522 M3LkTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwNEWyO{DPxE1? NFzVblBUSU6JRWK=
LCLC-97TM1 Mo\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fIWWlEPTB;MD60OlE6PSEQvF2= M3HsZ3NCVkeHUh?=
CAL-39 M2D1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwNE[1NVkh|ryP MlXuV2FPT0WU
CAL-120 NF74fW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwNEe2OFMh|ryP NUjQZoppW0GQR1XS
ESS-1 MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwNEe4NlEh|ryP MmDpV2FPT0WU
KARPAS-45 MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjmepRKSzVyPUCuOFg6OzNizszN NYLjbWZxW0GQR1XS
DU-4475 M2PH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwNEm1NVEh|ryP MnfKV2FPT0WU
VMRC-RCZ MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnZPHRPUUN3ME2wMlQ6QTB2IN88US=> NHTMW2tUSU6JRWK=
HOS NEC1[lJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;Le4RKSzVyPUCuOVA{PjVizszN NEfUNnZUSU6JRWK=
MOLT-16 NX;Yeo1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjRTWM2OD1yLkWxPFA5KM7:TR?= MmntV2FPT0WU
RPMI-6666 NVu1UVlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zrcGlEPTB;MD61NlE{PSEQvF2= NIjsSVhUSU6JRWK=
K052 NIHud2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz4TWM2OD1yLkWyNVQh|ryP NYLkVGZ1W0GQR1XS
EHEB M3G5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTkd2JJUUN3ME2wMlUzOTh{IN88US=> NF3tNXdUSU6JRWK=
MFH-ino NIS3RmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XuNWlEPTB;MD61NlM2OSEQvF2= NWHT[21WW0GQR1XS
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TE-12 NH33TJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwNUW3N|Uh|ryP M4fUWnNCVkeHUh?=
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LCLC-103H M1qwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPCTWM2OD1yLkW4N|Q1KM7:TR?= M2XCU3NCVkeHUh?=
OS-RC-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTEflJ1UUN3ME2wMlU5Ozd7IN88US=> NVX6dW1oW0GQR1XS
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A3-KAW MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\F[IpKSzVyPUCuOlE1PjdizszN NV7ON|BXW0GQR1XS
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EW-13 M3jKRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULMdmlsUUN3ME2wMlY3Pzd7IN88US=> MX\TRW5ITVJ?
647-V NHrmV|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwNkixOFgh|ryP MUXTRW5ITVJ?
JiyoyeP-2003 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\aTWM2OD1yLk[5O|M5KM7:TR?= MWfTRW5ITVJ?
WSU-NHL MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwN{C4PFch|ryP NVnxfYJYW0GQR1XS
U-698-M MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLnS2JKSzVyPUCuO|ExPjNizszN MVPTRW5ITVJ?
HC-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\Efo9OUUN3ME2wMlczPDB3IN88US=> NXzVcVM5W0GQR1XS
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LB1047-RCC M1\D[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDDTWM2OD1yLkezOVM5KM7:TR?= MVTTRW5ITVJ?
GAMG NIHIdYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;nTWM2OD1yLkezOlU{KM7:TR?= NH7CdJVUSU6JRWK=
CAL-12T NUSyd2NpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3jXVlKSzVyPUCuO|M5PzdizszN Mke2V2FPT0WU
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HTC-C3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[xTWM2OD1yLke3OFUyKM7:TR?= NInEfHJUSU6JRWK=
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KGN M2rVb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XpbGlEPTB;MD63PFA5OSEQvF2= NIG0eJRUSU6JRWK=
EFO-27 M4\HTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTieHhKSzVyPUCuO|g4OzNizszN MnzjV2FPT0WU
MEL-HO NGP4cYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHERmNLUUN3ME2wMlc6PDR7IN88US=> NHH0OopUSU6JRWK=
KYSE-270 NFHDfIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT1XXRWUUN3ME2wMlgxPTJ7IN88US=> MlzxV2FPT0WU
NCI-H1755 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\yTWM2OD1yLkiwO|E1KM7:TR?= MVTTRW5ITVJ?
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ETK-1 M3jGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3uwc2lEPTB;MD64NlQ1OSEQvF2= M4DKNnNCVkeHUh?=
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L-540 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPpTWM2OD1yLki1PFAyKM7:TR?= MnvUV2FPT0WU
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HT-1376 MkLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Loc2lEPTB;MD64OlA2OSEQvF2= M{fRZ3NCVkeHUh?=
COLO-680N MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTDTWM2OD1yLki3PVM{KM7:TR?= M{PxdHNCVkeHUh?=
NCI-H1581 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvlOHRmUUN3ME2wMlg6Ojl5IN88US=> MmDUV2FPT0WU
HuCCT1 MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwOEm1OFgh|ryP NFe5NmJUSU6JRWK=
BB30-HNC M1TQ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfienBKSzVyPUCuPVI1PjlizszN NWHSdYtbW0GQR1XS
NCI-H2347 NH\pPWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TVc2lEPTB;MD65N|I6OiEQvF2= NFzHR4RUSU6JRWK=
G-401 NVzZVpZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWn5ToJ3UUN3ME2wMlk{Pjl3IN88US=> NIHYZYJUSU6JRWK=
NCI-H358 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j3RmlEPTB;MD65OVAyPCEQvF2= MV\TRW5ITVJ?
HCC1395 NV7QOXVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\rdmlEPTB;MD65OVQ3OSEQvF2= NHfx[I9USU6JRWK=
J82 MlzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z3cmlEPTB;MD65OVU1OyEQvF2= MXzTRW5ITVJ?
KE-37 M3\TRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwOU[zPFch|ryP M4PCVHNCVkeHUh?=
NOMO-1 MmXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW3dldDUUN3ME2wMlk3PTZ2IN88US=> NGXKNGFUSU6JRWK=
ML-2 Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnaTWM2OD1yLkm5O|Uh|ryP M4P0NXNCVkeHUh?=
SW872 NHrQNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnXPWRKSzVyPUCuPVk4PzVizszN M{X2bHNCVkeHUh?=
KYSE-520 NY\uXmZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITWe|JKSzVyPUGuNFA1QTRizszN MoTiV2FPT0WU
HL-60 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULUS|BLUUN3ME2xMlAxQTdizszN M4nBNXNCVkeHUh?=
HDLM-2 M3jEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rlXWlEPTB;MT6wNVI2OiEQvF2= NX;Jc4F{W0GQR1XS
MIA-PaCa-2 M3jX[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVK2S5hJUUN3ME2xMlAyOzd3IN88US=> M33QcXNCVkeHUh?=
TCCSUP MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnviTWM2OD1zLkCxO|MzKM7:TR?= NI[1fWlUSU6JRWK=
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MG-63 M1jUbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\4WmlEPTB;MT6wNlYyPiEQvF2= NIHiTGpUSU6JRWK=
NB6 M2PWW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7vN5dLUUN3ME2xMlA{OTB7IN88US=> M{f3WnNCVkeHUh?=
CAL-54 M1O0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPE[3kzUUN3ME2xMlA{QTV7IN88US=> NIHL[IlUSU6JRWK=
DU-145 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwMEiwO|Mh|ryP Ml33V2FPT0WU
HCE-4 NX;EfYc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwMEmyPFYh|ryP NH\DXoZUSU6JRWK=
U-266 NFSwUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PBSWlEPTB;MT6wPVY{OyEQvF2= NYrjT2FFW0GQR1XS
HT-1197 NFG4N2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnabm1KSzVyPUGuNVE1OzhizszN NEXkV5FUSU6JRWK=
EW-1 Mon1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;MTWM2OD1zLkG0NVI5KM7:TR?= NWfY[3JiW0GQR1XS
MHH-NB-11 NIftV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHGRo1iUUN3ME2xMlE2OzZ6IN88US=> NH3mZmFUSU6JRWK=
NCI-H2405 NFfZNpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTFwMU[xOkDPxE1? M1jtcHNCVkeHUh?=
COLO-668 NGTOUWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD2c4tKSzVyPUGuNVY1QSEQvF2= MXvTRW5ITVJ?
IMR-5 NYLXfnVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrVTWM2OD1zLkG2PVM3KM7:TR?= MoH0V2FPT0WU
ARH-77 M2nFbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rYWWlEPTB;MT6yNlkzPCEQvF2= MYfTRW5ITVJ?
BHT-101 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfwTWM2OD1zLkKzOFkh|ryP NUPNfndHW0GQR1XS
SCC-25 MkXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPuSYFFUUN3ME2xMlI{PTN4IN88US=> NX36[YZHW0GQR1XS
NTERA-S-cl-D1 NIq3emVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTFwMkSzOFYh|ryP NF;mXFBUSU6JRWK=
MKN28 NVfpSZQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFwMkW2N|Yh|ryP MWDTRW5ITVJ?
KS-1 M4r5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFwMkiyOlkh|ryP NF;FOIxUSU6JRWK=
NCI-H1734 Mn;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC1TWM2OD1zLkK4PVE{KM7:TR?= NUO2T|hHW0GQR1XS
ES7 MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfETWM2OD1zLkK5OVQzKM7:TR?= MkPpV2FPT0WU
NCI-H838 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe2T2xKSzVyPUGuN|A3OTVizszN NVzCWpY6W0GQR1XS
HEC-1 NGS1bJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon6TWM2OD1zLkOzO|U2KM7:TR?= NGHZOIFUSU6JRWK=
ME-180 NEPxfodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlznTWM2OD1zLkO3PVk{KM7:TR?= NV65OXhMW0GQR1XS
MMAC-SF NGLUOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXOTWM2OD1zLkO5OVk2KM7:TR?= M{nINXNCVkeHUh?=
IA-LM MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlriTWM2OD1zLkSwPVE1KM7:TR?= M1ju[XNCVkeHUh?=
MN-60 MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLRNFhKSzVyPUGuOFMyOTRizszN NVT6XVM5W0GQR1XS
SIMA NH:4TJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrIUWJMUUN3ME2xMlQ5Pjh5IN88US=> NVfn[2NqW0GQR1XS
NCI-H1770 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LpSmlEPTB;MT61NlA2PCEQvF2= MlrFV2FPT0WU
ONS-76 M1HSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi1SIlkUUN3ME2xMlUzOzFzIN88US=> MnnUV2FPT0WU
LB771-HNC NWHFRox{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDQeFdlUUN3ME2xMlU{QTB4IN88US=> MoC5V2FPT0WU
SW48 NEn5NG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnaO3NKSzVyPUGuOVQzPDNizszN NIPFXJRUSU6JRWK=
KYSE-140 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;DR5REUUN3ME2xMlU2PzRzIN88US=> NH3y[WlUSU6JRWK=
SW626 NX7rT|RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XNfGlEPTB;MT61PFE3KM7:TR?= MmXJV2FPT0WU
MC-CAR Mnv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XFTmlEPTB;MT61PFY3OyEQvF2= NGrvbopUSU6JRWK=
D-336MG NHfXVZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqxTWM2OD1zLk[yPVQh|ryP NETSVoZUSU6JRWK=
SK-MEL-3 NYXGbFFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\MO5RvUUN3ME2xMlY{QTB{IN88US=> M{LpTHNCVkeHUh?=
MHH-PREB-1 M3zrZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PqXmlEPTB;MT62OFQ4OyEQvF2= MYjTRW5ITVJ?
Calu-1 MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH2RodKSzVyPUGuOlU{QDZizszN NYLBNYNKW0GQR1XS
HCC1806 NWD1d3lvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTHTWM2OD1zLk[2OlEyKM7:TR?= M4rCTXNCVkeHUh?=
A101D MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny4TWM2OD1zLk[2O|gyKM7:TR?= NWDWUmx[W0GQR1XS
A704 NVLscZFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlGxTWM2OD1zLk[4N|EyKM7:TR?= MnvxV2FPT0WU
LB831-BLC MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLLTWM2OD1zLk[5PFU1KM7:TR?= NEPzWm9USU6JRWK=
RL95-2 NULObo1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP4dppxUUN3ME2xMlcyPDZ|IN88US=> NVPNcXFzW0GQR1XS
RPMI-2650 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO0SpZKSzVyPUGuO|I4OTlizszN NFr4VYZUSU6JRWK=
NH-12 M{TIbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLN[3lGUUN3ME2xMlc{PDJ5IN88US=> NUXGXJpyW0GQR1XS
AGS NWq1fZF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjzTWM2OD1zLke2N|U5KM7:TR?= NVzqUnZ2W0GQR1XS
NEC8 NIrWTW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTFwN{i5PVUh|ryP NF[3TGJUSU6JRWK=
NCI-H2009 M1TtWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4WzTGlEPTB;MT63PVczOSEQvF2= MUDTRW5ITVJ?
A498 M{m0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX1TWM2OD1zLkixNlgzKM7:TR?= NVKzTVd7W0GQR1XS
NCI-H810 M1\vcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHvTWM2OD1zLkixOlA3KM7:TR?= MUXTRW5ITVJ?
SK-NEP-1 MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwOEO3Olch|ryP NXftVo5xW0GQR1XS
D-542MG MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTiVoxUUUN3ME2xMlg2QDVzIN88US=> NULCXphpW0GQR1XS
KNS-42 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFwOE[yOlYh|ryP MYHTRW5ITVJ?
NCI-H2452 M1KwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfvS2tKSzVyPUGuPFkxPzRizszN NFH0OpRUSU6JRWK=
SK-MEL-2 M1f6W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTFwOUCyO|Eh|ryP MnjkV2FPT0WU
OVCAR-5 NX[zdVNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXpb21KSzVyPUGuPVA3PzVizszN MoLQV2FPT0WU
SNG-M MkO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvBe|dKSzVyPUGuPVU5PThizszN MonBV2FPT0WU
A673 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7sUJRKSzVyPUGuPVc2OTZizszN MY\TRW5ITVJ?
L-428 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3lTWM2OD1zLkm5NVc6KM7:TR?= M3HoOHNCVkeHUh?=
KM-H2 M{PKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXmTWM2OD1{LkCxNFkh|ryP NYXHNYNVW0GQR1XS
MC-IXC M1Xt[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTJwMEKyO|Mh|ryP M3vpR3NCVkeHUh?=
COLO-678 M{LKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGeyNFNKSzVyPUKuNFQzODdizszN NXfOTlZwW0GQR1XS
MEL-JUSO NXPOdpRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TRNmlEPTB;Mj6wO|g2OSEQvF2= MV7TRW5ITVJ?
HCC38 NITMeWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnaeIpEUUN3ME2yMlA5PDN|IN88US=> NVvLS2EyW0GQR1XS
UACC-62 NVLzN3kyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDSTWM2OD1{LkC4PFU2KM7:TR?= NWThbJJVW0GQR1XS
OAW-42 NHvUW3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnywTWM2OD1{LkC5O|EyKM7:TR?= NVfFcpFtW0GQR1XS
LB996-RCC M1H1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WydWlEPTB;Mj6xN|gyPyEQvF2= MXrTRW5ITVJ?
COR-L105 NYXmdJd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTVPZRKSzVyPUKuNVY{PzNizszN MkfDV2FPT0WU
RCC10RGB M4HX[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLQTWM2OD1{LkG4OVc3KM7:TR?= M4fSZnNCVkeHUh?=
A431 M1TMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJwMUmwNVkh|ryP MkTCV2FPT0WU
NCI-H292 NW\I[2JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDrRWE4UUN3ME2yMlI{QTVzIN88US=> MX7TRW5ITVJ?
SK-UT-1 MofCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJwM{OxPFQh|ryP NFfNO5pUSU6JRWK=
PANC-08-13 M{HxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;sUldKSzVyPUKuN|MzOzVizszN MYTTRW5ITVJ?
ST486 NU[xe28xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHzflBpUUN3ME2yMlQyODR6IN88US=> NFzBNJVUSU6JRWK=
SJSA-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfyTWM2OD1{LkSxNlcyKM7:TR?= NVTHcHM1W0GQR1XS
RKO MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj2WHdqUUN3ME2yMlQzODJ7IN88US=> M4PXZ3NCVkeHUh?=
NCI-H1793 NF7CS3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ja[mlEPTB;Mj60OFAzQSEQvF2= NYP4OoRMW0GQR1XS
639-V NUSwW5ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJwNEWzPFIh|ryP NFnIXVJUSU6JRWK=
ES3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTQTWM2OD1{LkS5O|M4KM7:TR?= MnK1V2FPT0WU
NCI-H1792 NYXnPIxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF2y[pNKSzVyPUKuOVY5OjZizszN MU\TRW5ITVJ?
NCI-H1651 M4rkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojLTWM2OD1{LkW4NlEh|ryP M4W5XnNCVkeHUh?=
SN12C NHLWNVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjk[pNKSzVyPUKuOVg1QDdizszN MXfTRW5ITVJ?
COLO-679 MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJwNUi2NFUh|ryP NEnVcplUSU6JRWK=
U-118-MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjNVodKSzVyPUKuOVg5PzJizszN NVn2TYNWW0GQR1XS
Ramos-2G6-4C10 M17IcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7x[2RHUUN3ME2yMlY1QDB5IN88US=> NIfYRYdUSU6JRWK=
HCT-15 M4j5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3ETWM2OD1{Lk[4O|kzKM7:TR?= NGLiT4VUSU6JRWK=
MDA-MB-157 Mn;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PUcGlEPTB;Mj63NFc1PyEQvF2= NX3aVYtWW0GQR1XS
K5 NHfTXG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\H[WlEPTB;Mj63NVg1PSEQvF2= MnnoV2FPT0WU
MKN45 M2HDNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXqTWM2OD1{LkezN|Y3KM7:TR?= MlHxV2FPT0WU
DMS-273 NGi1UndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnQRlBKSzVyPUKuO|U3OzJizszN NXHTVpNZW0GQR1XS
C8166 M{jSUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJwN{i1NVMh|ryP MYDTRW5ITVJ?
Calu-3 NGHr[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLiTWM2OD1{Lke4PVY6KM7:TR?= NVTVNZZUW0GQR1XS
SNB75 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTJwOEi1N|Uh|ryP NYnVcGNLW0GQR1XS
BFTC-905 M3zZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJwOUCxPVEh|ryP Ml;rV2FPT0WU
C-4-II M2HZZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3lXXBKSzVyPUKuPVE{PTNizszN NEnUcJZUSU6JRWK=
MS-1 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJwOU[3Olkh|ryP M{j1Z3NCVkeHUh?=
A375 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfjRYFKSzVyPUOuNFgyQDRizszN NGrLSVlUSU6JRWK=
KYSE-70 MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LNRmlEPTB;Mz6wPFg5OiEQvF2= NYPFVWd3W0GQR1XS
KYSE-510 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTNwMUC5PVUh|ryP MlnwV2FPT0WU
LN-405 MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHYTWM2OD1|LkGzOVE5KM7:TR?= MlLuV2FPT0WU
BOKU MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjZNXNKSzVyPUOuNVQzPTZizszN MYHTRW5ITVJ?
TE-10 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTNwMUezOlIh|ryP M2XyNHNCVkeHUh?=
MKN1 Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXSTVhKSzVyPUOuNVg1QDNizszN MojYV2FPT0WU
M059J MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq5TWM2OD1|LkKwNVc{KM7:TR?= NGe1TlZUSU6JRWK=
GOTO MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXFTWM2OD1|LkKyNFM6KM7:TR?= Mn7uV2FPT0WU
DK-MG NWe4UJE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r6S2lEPTB;Mz6yOVk4PiEQvF2= MW\TRW5ITVJ?
NCI-H727 M{flVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXXXWM6UUN3ME2zMlI3PThizszN MWrTRW5ITVJ?
NB12 NVHud4kxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;lb3RlUUN3ME2zMlM{OjJ2IN88US=> NX[1VotZW0GQR1XS
DOK NUi0eVJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\ITWM2OD1|LkO2NVg3KM7:TR?= MXXTRW5ITVJ?
KYSE-410 M1jLe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7nTWM2OD1|LkO2Nlg4KM7:TR?= NVLXTVFLW0GQR1XS
AM-38 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT4TYJTUUN3ME2zMlM5ODVzIN88US=> M2fkVnNCVkeHUh?=
GR-ST NFi0cXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HOSGlEPTB;Mz60OVc{OiEQvF2= NGXCdI1USU6JRWK=
D-247MG NUfj[IcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTNwNEiyOlMh|ryP MlLTV2FPT0WU
TE-8 MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fKRmlEPTB;Mz60PVM{OyEQvF2= MXTTRW5ITVJ?
LS-411N MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TNUmlEPTB;Mz60PVY6OiEQvF2= MUjTRW5ITVJ?
SK-MES-1 NGnRb5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHxcXZKSzVyPUOuOVY1OzNizszN NY\U[GNtW0GQR1XS
SF295 Moj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTNwNkG1OVIh|ryP NUTteJVFW0GQR1XS
SK-MEL-30 M3zyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVntUJpYUUN3ME2zMlY2QTJzIN88US=> M1G4OnNCVkeHUh?=
LB2241-RCC M1HpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moj5TWM2OD1|Lk[2NlYh|ryP NXTSOJZKW0GQR1XS
PC-14 Mor6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTNwNk[0N|ch|ryP MWnTRW5ITVJ?
EW-7 NIPVTGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj5UXZ5UUN3ME2zMlY4Pjl|IN88US=> MUTTRW5ITVJ?
NMC-G1 NFPHcYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTNwN{G4N|ch|ryP NWToZZkzW0GQR1XS
TE-441-T NF24UXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz6SnlGUUN3ME2zMlc{ODJ6IN88US=> NHHWW4hUSU6JRWK=
NCI-H1618 NVqx[nNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG5TWM2OD1|LkixPFc2KM7:TR?= NHzSPGdUSU6JRWK=
PANC-03-27 MnrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HBW2lEPTB;Mz64NVkyPiEQvF2= NEDsVIVUSU6JRWK=
NCI-H2228 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTNwOEOxNlYh|ryP NUPCPWJNW0GQR1XS
CAPAN-1 NGPQVXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe5bZdKSzVyPUOuPFcxODlizszN M{ftenNCVkeHUh?=
KLE NVXKUo05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17pVWlEPTB;Mz65NFY4KM7:TR?= MmLaV2FPT0WU
Becker MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrtVmlKSzVyPUOuPVI5PDlizszN NFz1UmpUSU6JRWK=
SK-PN-DW NVH3fFN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi1TJNWUUN3ME20MlA4QTd2IN88US=> Moq0V2FPT0WU
Hs-578-T NWflTYc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTRwMEizNFYh|ryP MlL5V2FPT0WU
RS4-11 MonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LSRWlEPTB;ND6xNVI2PSEQvF2= MnjKV2FPT0WU
D-502MG NEjQWYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL3TWM2OD12LkG2PVk4KM7:TR?= MY\TRW5ITVJ?
GI-1 NIHxdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHjXWpKSzVyPUSuNlgzQTlizszN MljXV2FPT0WU
NCI-H209 NUD3VmtHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXiTWM2OD12LkOzO|gh|ryP NV\GPJF{W0GQR1XS
SK-OV-3 M37DUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TCdmlEPTB;ND60PFE1QSEQvF2= NVHocZZRW0GQR1XS
LOUCY MmPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTsZYc4UUN3ME20MlQ5PDN{IN88US=> M33jSnNCVkeHUh?=
NCI-H69 MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXJU|ZKSzVyPUSuOVE4QTNizszN NXzrPIhWW0GQR1XS
SCC-9 NYi3ephuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjMOXJKSzVyPUSuOVMyPzJizszN NFzTUJBUSU6JRWK=
NCI-H526 M336eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTRwNUmyPVMh|ryP NILjWIZUSU6JRWK=
NCI-H2170 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\wTWM2OD12Lk[2O|cyKM7:TR?= MXfTRW5ITVJ?
SR NVuyfppzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\Re2lEPTB;ND63NFA1QCEQvF2= Mly0V2FPT0WU
CMK NXntR2FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTRwN{KxNFEh|ryP MX;TRW5ITVJ?
COLO-829 M16xVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PvSWlEPTB;ND63O|A1OyEQvF2= Ml[wV2FPT0WU
HuO-3N1 MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS0NmpMUUN3ME20Mlg{OjhzIN88US=> NGDkUJhUSU6JRWK=
5637 NHrwPHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfUSXRKSzVyPUSuPVA1QDdizszN M2\3VXNCVkeHUh?=
A253 NHLVZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzzWmZjUUN3ME20Mlk4PzB6IN88US=> NI\Xb2NUSU6JRWK=
NB10 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjDSJdKSzVyPUWuNFc1QTdizszN NWnjRYw{W0GQR1XS
SF539 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn5eWlKSzVyPUWuNFk6PTlizszN MYHTRW5ITVJ?
HAL-01 NHXsdFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTVwMUS2OFUh|ryP NXjmWVFkW0GQR1XS
MHH-ES-1 NIO5eXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTVwMU[5NlUh|ryP M{j6b3NCVkeHUh?=
DEL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL2TWM2OD13LkK3OVgzKM7:TR?= MXHTRW5ITVJ?
NCI-H1299 Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjzU5RqUUN3ME21MlM2ODB5IN88US=> Moq0V2FPT0WU
ChaGo-K-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DVOGlEPTB;NT6zOVExPyEQvF2= MWHTRW5ITVJ?
HMV-II M1z0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorKTWM2OD13LkO5OFMh|ryP NGLUN4NUSU6JRWK=
NB69 NFjWb5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorQTWM2OD13LkO5OlMyKM7:TR?= M{XWOHNCVkeHUh?=
NCI-H1882 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi1TWM2OD13LkSzN|Y1KM7:TR?= NUKwcpF6W0GQR1XS
SNU-475 NIXvfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj1RVRYUUN3ME21MlQ4OTdzIN88US=> NFPub4ZUSU6JRWK=
RXF393 NHPKWnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljTTWM2OD13LkS4OFk1KM7:TR?= MUnTRW5ITVJ?
CAL-51 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjWd|RLUUN3ME21MlYzQDV|IN88US=> NGPJ[3hUSU6JRWK=
SW1573 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTVwNkO1N|Qh|ryP NWDNcoxKW0GQR1XS
GCT NFnOeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[4TWM2OD13Lke1PVI6KM7:TR?= M1XIUHNCVkeHUh?=
COR-L88 NIXHTo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nCWmlEPTB;NT63Olg1PiEQvF2= Mke4V2FPT0WU
MDA-MB-134-VI Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTVwOEe1N|Yh|ryP NXmyRnA4W0GQR1XS
NB5 M3;L[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHT[FdKSzVyPUWuPVI1PCEQvF2= NVTaZ5U5W0GQR1XS
GMS-10 NF22fYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjlR|VKSzVyPUWuPVY5PjFizszN MYnTRW5ITVJ?
CHP-212 M1nOSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWroT2tJUUN3ME22MlQ5OjZ5IN88US=> M1u5cnNCVkeHUh?=
TE-11 M1TiUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;pTWM2OD14LkW1NVgzKM7:TR?= NHjtbWNUSU6JRWK=
SW962 MmrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDGTWM2OD14Lk[1O|c1KM7:TR?= MlvqV2FPT0WU
MZ2-MEL NVeySo1kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jlOmlEPTB;Nj64NlAyOSEQvF2= NF;qZmZUSU6JRWK=
C-33-A MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jnXmlEPTB;Nj65NVY5QCEQvF2= NHnBWodUSU6JRWK=
IGR-1 NEHjOVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlKyTWM2OD14Lkm3PFI3KM7:TR?= MYjTRW5ITVJ?
MOLT-4 NXPiSnFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrMTWM2OD15LkG1OFA3KM7:TR?= MVPTRW5ITVJ?
NCI-H1650 NFf4U5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Ljc2lEPTB;Nz6yO|A1PiEQvF2= MYjTRW5ITVJ?
AsPC-1 M3\zTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nrW2lEPTB;Nz6yPFYxPSEQvF2= NX71ZZEyW0GQR1XS
SNU-C2B MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTdwMkm1O|Eh|ryP M1jYV3NCVkeHUh?=
MKN7 NV;FcIVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fDOGlEPTB;Nz6zO|I{PSEQvF2= Mke0V2FPT0WU
SW620 M1;kdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTdwM{iyNFUh|ryP MXfTRW5ITVJ?
SK-MEL-28 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7GTWM2OD15LkSwO|k5KM7:TR?= MkjvV2FPT0WU
TE-6 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LmdGlEPTB;Nz60OFkxQCEQvF2= MX;TRW5ITVJ?
D-263MG NYrObpgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PX[2lEPTB;Nz60OVc3OiEQvF2= MlWyV2FPT0WU
NCI-H1355 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTjSHVnUUN3ME23Mlc4ODJ7IN88US=> MYLTRW5ITVJ?
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HCE-T MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTITWM2OD1{Mj64OlA3KM7:TR?= MonvV2FPT0WU
BB65-RCC M2HLcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[ySGlEPTB;MkOuNFM1PCEQvF2= NVrhNng1W0GQR1XS
SiHa NIj2eohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHf5bXdKSzVyPUKzMlM6PjhizszN NWC2So84W0GQR1XS
NCI-H2081 M17ZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\BRoN[UUN3ME2yOE4xPjRzIN88US=> NHrtfldUSU6JRWK=
U251 M2L0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf0UWZKSzVyPUK0MlA3PjhizszN MoPyV2FPT0WU
LoVo M1q2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW2TpRSUUN3ME2yOE46Ojh{IN88US=> MVrTRW5ITVJ?
GCIY NF76W3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7ZVFNKSzVyPUK1MlI5PzdizszN NEnjbG9USU6JRWK=
NUGC-3 NEPGbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTURoVKSzVyPUK1MlM{OTZizszN MVnTRW5ITVJ?
LNCaP-Clone-FGC NGixXlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTDTWM2OD1{NT6zOFk5KM7:TR?= M1vWZnNCVkeHUh?=
PA-1 NFrOSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;WTlRUUUN3ME2yOU43QDN|IN88US=> MoPWV2FPT0WU
OE33 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmeyTWM2OD1{NT62PFU{KM7:TR?= NXPIXHpKW0GQR1XS
HT-29 NF3xPVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjBSWViUUN3ME2yOU44QDd7IN88US=> MoPDV2FPT0WU
RCM-1 M4XQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTJ3Lkm2OVYh|ryP M1L4eXNCVkeHUh?=
NCI-H1522 NHO3cHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLMTWM2OD1{NT65PVEyKM7:TR?= MYPTRW5ITVJ?
LB373-MEL-D MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;6NmlEPTB;Mk[uNVcxQCEQvF2= NF;FNJdUSU6JRWK=
NCI-H1436 M4TKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\mXWlEPTB;Mk[uNlc{QCEQvF2= NVjmNYNVW0GQR1XS
COLO-824 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPaPIl{UUN3ME2yOk41ODB{IN88US=> NHP5UINUSU6JRWK=
CP50-MEL-B M4\MVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTwTWM2OD1{Nj61Olc2KM7:TR?= M2PidnNCVkeHUh?=
EGI-1 M1foU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\TZYhKSzVyPUK3MlI3QThizszN NXjNe5hMW0GQR1XS
LAN-6 MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDJRZFFUUN3ME2yO{4{PTl6IN88US=> NUflTJFyW0GQR1XS
GAK NHeyO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJ5LkSyNlUh|ryP NYHG[HhlW0GQR1XS
MDA-MB-175-VII M{jFc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHK[Y5HUUN3ME2yO{42ODV|IN88US=> MVPTRW5ITVJ?
JVM-2 Mn73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJ5Lk[2NlIh|ryP MnH4V2FPT0WU
UACC-257 NHnhT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfTZYFOUUN3ME2yO{43QDd6IN88US=> NXu0b4hGW0GQR1XS
SW1783 NYDLWpRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HhXWlEPTB;MkeuO|c5OyEQvF2= M2fEXXNCVkeHUh?=
HT-3 M4m1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJ6LkKxOlYh|ryP MmXSV2FPT0WU
RL NEnKOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrBeIVkUUN3ME2yPE42QTFzIN88US=> NWm2RZA1W0GQR1XS
TK10 NEXXXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ6Lk[1N|Uh|ryP M3jRcnNCVkeHUh?=
HT55 NXvl[2Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELWU|BKSzVyPUK5MlA2PjVizszN NYHwTYdVW0GQR1XS
BT-20 Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJ7LkC1PFYh|ryP NWr3Znp6W0GQR1XS
TGBC24TKB NGTRUJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJ7LkG4N|Eh|ryP NFzGfnNUSU6JRWK=
HSC-2 NV6wTXlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ7LkOwNFEh|ryP MWjTRW5ITVJ?
COLO-205 M{DGXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITSXoVKSzVyPUK5MlM6PDRizszN NIjpc4NUSU6JRWK=
GT3TKB NWLJTG43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PQOGlEPTB;MkmuOlg4PyEQvF2= NF32RYNUSU6JRWK=
T47D MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTJ7Lki1PFIh|ryP NEfn[HdUSU6JRWK=
OMC-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG0TWM2OD1|MD6xPVE6KM7:TR?= MmDXV2FPT0WU
PFSK-1 M{mxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTZWncyUUN3ME2zNU4zPjV7IN88US=> M4fJfHNCVkeHUh?=
JEG-3 NH7CTlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfVVXRKSzVyPUOxMlM2PjFizszN Ml3RV2FPT0WU
RD NVfMRY5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTNzLkWxNVUh|ryP NFjF[HRUSU6JRWK=
NCI-H64 NV\OVItOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTN{LkSxO|kh|ryP NYf2VFlKW0GQR1XS
DMS-114 Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTN{LkSxPFIh|ryP Ml;OV2FPT0WU
NCI-H661 NXe3[pkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX3TWM2OD1|Mj62OVAyKM7:TR?= MYDTRW5ITVJ?
CAL-148 M{fhVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC4b4VwUUN3ME2zNk43PjZ3IN88US=> NYKzWmRKW0GQR1XS
HuP-T3 NVq0TWd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHiTWM2OD1|Mj65N|M5KM7:TR?= NXPhZXl7W0GQR1XS
ES4 Mn3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTN|LkG3NFUh|ryP MUDTRW5ITVJ?
Ca9-22 NF3zOmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfrdY5KSzVyPUOzMlQ3ODFizszN NUXZZZZbW0GQR1XS
LP-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHWNXNPUUN3ME2zOE4xQSEQvF2= M2f4R3NCVkeHUh?=
AU565 M{nyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHmTWM2OD1|ND61NFY6KM7:TR?= NEKyTmZUSU6JRWK=
MDA-MB-453 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojDTWM2OD1|NT6xOFI3KM7:TR?= NIfVSlJUSU6JRWK=
SNU-C1 NF3FO29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3sVodKSzVyPUO1MlE4OSEQvF2= NInW[pBUSU6JRWK=
SW13 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnVfoMzUUN3ME2zOU41ODd4IN88US=> M1m0XHNCVkeHUh?=
NCI-H2122 MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHONWtKSzVyPUO1MlU2QThizszN NEDtdZJUSU6JRWK=
NCI-H1395 M3f5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nQ[mlEPTB;M{WuOlY6OSEQvF2= Mn3ZV2FPT0WU
J-RT3-T3-5 M1izVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ewcWlEPTB;M{[uNFI6PCEQvF2= M3m2OXNCVkeHUh?=
COR-L279 M{LWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe1TWM2OD1|Nj6xPVgyKM7:TR?= M{D1XXNCVkeHUh?=
ATN-1 NGnUcG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTN4Lki1NVYh|ryP MXnTRW5ITVJ?
HCC2998 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml60TWM2OD1|Nj64OVcyKM7:TR?= MoHKV2FPT0WU
UM-UC-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u3O2lEPTB;M{[uPFY4PSEQvF2= MkOzV2FPT0WU
DV-90 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzjS|ZKSzVyPUO2MlkxPjdizszN NXjBN25OW0GQR1XS
ES8 NYrEcXFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHyTWM2OD1|Nj65N|E5KM7:TR?= MnjZV2FPT0WU
YAPC MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnJTWM2OD1|Nj65OlU1KM7:TR?= MnXaV2FPT0WU
HCC1599 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXSXFZQUUN3ME2zO{4yPjF6IN88US=> MkDDV2FPT0WU
UMC-11 NEftTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzLO2dKSzVyPUO3MlI2ODNizszN MXnTRW5ITVJ?
THP-1 M4\HZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN5LkK4Olgh|ryP M37V[3NCVkeHUh?=
OCUB-M NFHnelBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;4WGVQUUN3ME2zO{4zQDlzIN88US=> MlHoV2FPT0WU
NCI-H1693 NXXFWXdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHI[IFoUUN3ME2zO{4{OjN|IN88US=> NFnP[4VUSU6JRWK=
NCI-H345 M4rxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LWZmlEPTB;M{euN|YzPCEQvF2= NWfJOHZHW0GQR1XS
COLO-800 NW\KcZNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTN5LkW2O{DPxE1? NU[3fIMyW0GQR1XS
COLO-320-HSR MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfSSlZKSzVyPUO4MlM1QTJizszN MlzaV2FPT0WU
NCI-H596 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDkSoRKSzVyPUO4MlQ1QDlizszN M{PQZnNCVkeHUh?=
NCI-H187 M3LDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHGT|hyUUN3ME2zPE44OzR2IN88US=> M2\KcnNCVkeHUh?=
ECC4 NHvyOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\0[GlEPTB;M{muNFgyPCEQvF2= MX7TRW5ITVJ?
KP-4 M3zPVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq0WHZKSzVyPUO5MlEzOzVizszN M2fPVXNCVkeHUh?=
NCI-H2227 M1vYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHCTWM2OD1|OT6zPVQ6KM7:TR?= NV21bFdPW0GQR1XS
22RV1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTN7LkizPVgh|ryP NHzKUHlUSU6JRWK=
SAS MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\ZOmdKSzVyPUSwMlA6PiEQvF2= NUTJ[FhVW0GQR1XS
PANC-10-05 MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTRyLkG4Nlgh|ryP NX\FUJluW0GQR1XS
MDA-MB-468 M4fpZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rHfWlEPTB;NECuOVM1PiEQvF2= MWnTRW5ITVJ?
RPMI-7951 NWK0PJVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4iybmlEPTB;NEGuNlA4PSEQvF2= MkfhV2FPT0WU
BB49-HNC NF;rfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLRUFFKSzVyPUSxMlIyPzlizszN NFvFdI1USU6JRWK=
23132-87 NHi0[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q0T2lEPTB;NEGuNlc{OiEQvF2= MUnTRW5ITVJ?
HCC1569 NES2cXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTzPVZKSzVyPUSxMlI5QDVizszN NYC3fWhzW0GQR1XS
CP66-MEL MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTR{LkG4PFYh|ryP MWXTRW5ITVJ?
K-562 NGPabYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH4TWM2OD12Mj6yPFU1KM7:TR?= NWfIdJd5W0GQR1XS
OCI-AML2 M3e1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\xTWM2OD12Mj64PVc1KM7:TR?= M3P2eHNCVkeHUh?=
SW756 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHhTWM2OD12Mz6wN|g5KM7:TR?= MmizV2FPT0WU
M14 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWKzTWRqUUN3ME20N{4{OTh7IN88US=> NX73dVY1W0GQR1XS
NCI-H1623 NXTrcZEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HKbGlEPTB;NEOuOFY1KM7:TR?= NHLkO|lUSU6JRWK=
KNS-81-FD NWjYcYpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTR|Lke2NkDPxE1? MmKzV2FPT0WU
TGBC1TKB NE\CTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu0Ulc{UUN3ME20N{46ODl7IN88US=> MXTTRW5ITVJ?
RERF-LC-MS NYrDWllQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTR|LkmyPFEh|ryP M1KxenNCVkeHUh?=
PC-3 M1vnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTFWJVlUUN3ME20OE41OzR5IN88US=> NHrRbphUSU6JRWK=
HuP-T4 NWHoZWx5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTR2LkS0O|Qh|ryP NYf4VmVFW0GQR1XS
NCI-H510A MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWWwd2dYUUN3ME20OE44ODhizszN MlnHV2FPT0WU
LB2518-MEL NFnpeY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjrTWlKSzVyPUS0Mlc6OzdizszN M4HJVnNCVkeHUh?=
TE-5 Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HqdGlEPTB;NEWuPVU5OSEQvF2= NVTY[lczW0GQR1XS
EW-24 M3zOcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLpRVVKSzVyPUS2MlE4OjNizszN MlHuV2FPT0WU
LB647-SCLC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTYcFRjUUN3ME20Ok4zOTV3IN88US=> MluwV2FPT0WU
NCI-H524 NIHoe5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXlTWM2OD12Nj63NVg2KM7:TR?= NYT5dJU6W0GQR1XS
EW-11 MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXYWY1lUUN3ME20Ok46Ozd|IN88US=> MmPoV2FPT0WU
KALS-1 M4DYd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTR5LkKwOlYh|ryP M2HKbHNCVkeHUh?=
BT-474 NGC3XXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoO3TWM2OD12Nz60NlE3KM7:TR?= NFTh[nZUSU6JRWK=
SK-N-AS M1LJRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDmWHRWUUN3ME20O{45QDhizszN NUTqOmxCW0GQR1XS
HCC2157 NETUWppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS5TZROUUN3ME20PE4xPzZizszN M2jufnNCVkeHUh?=
HCC1954 NYLz[ocxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnDb3hYUUN3ME20PE4yPzB2IN88US=> NEXPcnZUSU6JRWK=
FADU NYj1Nph5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXWxZ2ZPUUN3ME20PE4{ODNzIN88US=> NHnEOHFUSU6JRWK=
S-117 NYL6TYM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXZTWM2OD12OD6zPFE2KM7:TR?= MWrTRW5ITVJ?
LS-1034 M1\zemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe0R3hDUUN3ME20PE44ODZ5IN88US=> NFK2OWVUSU6JRWK=
CAMA-1 NXHveINST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfrR3d{UUN3ME20PU42PTR|IN88US=> MVfTRW5ITVJ?
LU-134-A NVK5UGxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHn[ppKSzVyPUS5MlgxQDVizszN M4K5VXNCVkeHUh?=
NCI-H1838 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTR7LkiwPFch|ryP MkTEV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]
臨床試験 AP24534 is currently under Phase II clinical trials in treatment with leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Peptide substrate phosphorylation assays with GST-Abl kinase domains The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.

細胞アッセイ: [2]

細胞株 Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
濃度 0-625 nM
反応時間 72 hours
実験の流れ Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat

動物実験: [1]

動物モデル Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
製剤 Dissolved in 25 mM citrate buffer, pH 2.75
投薬量 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
投与方法 Oral gavage once daily

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Ponatinib (AP24534) SDF
分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 3-(2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

文献中の引用 (25)

Frequently Asked Questions

  • Question 1
    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

    Answer: Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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