Ponatinib (AP24534) 化学構造
分子量: 532.56

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Quality Control & MSDS

製品説明

  • Compare Bcr-Abl Inhibitors
    Bcr-Abl製品生物活性の比較
  • 研究分野
  • Ponatinib (AP24534)のメカニズム

製品の説明

生物活性

製品説明 Ponatinib (AP24534) は、PI3KγとPI4KIIIβの新しくて強力な阻害剤で、IC50 がそれぞれ16 nM と 19 nMになる。
ターゲット Abl PDGFRα VEGFR2 FGFR1 Src
IC50 0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM [1]
In vitro試験 AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell M{XTfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[0bZgxUUN3ME2wMlAxODByMECzOVkh|ryP M{WyN3NCVkeHUh?=
MV-4-11 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnftTWM2OD1yLkCwNFA6PTZizszN MYTTRW5ITVJ?
MEG-01 NYXqe2VRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\ETWM2OD1yLkCwNFEzQCEQvF2= NUjn[5Y5W0GQR1XS
LAMA-84 M2LxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPPbWtiUUN3ME2wMlAxODF4NTFOwG0> M{\SUHNCVkeHUh?=
CGTH-W-1 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7tPVIxUUN3ME2wMlAxOTZ7IN88US=> NYPKPWI5W0GQR1XS
KASUMI-1 NUTLbG5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITVbW1KSzVyPUCuNFAzOTdizszN NX3UfWk5W0GQR1XS
BE-13 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPwe3VLUUN3ME2wMlAxOjV7IN88US=> NGS2SJlUSU6JRWK=
CTV-1 NFLqXVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnoZph[UUN3ME2wMlAxPTJzIN88US=> M{Gw[3NCVkeHUh?=
NKM-1 M4HpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PsdGlEPTB;MD6wNFY2PSEQvF2= MlH0V2FPT0WU
MONO-MAC-6 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjNZ5lKSzVyPUCuNFA5OzdizszN MULTRW5ITVJ?
A204 NW[xfG91T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC3XZZUUUN3ME2wMlAyOjF6IN88US=> NVPI[ZRIW0GQR1XS
GDM-1 NGS2[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEG4N|Mh|ryP MnzWV2FPT0WU
AN3-CA M3XBSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrTcJhKSzVyPUCuNFE5PzNizszN MYXTRW5ITVJ?
BL-70 M2DXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrrepo6UUN3ME2wMlAzOTl7IN88US=> MojSV2FPT0WU
Daudi M1PhN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\rOoVKSzVyPUCuNFI2OzdizszN MVnTRW5ITVJ?
KU812 MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j1d2lEPTB;MD6wNlg1QCEQvF2= NIXKbZJUSU6JRWK=
KG-1 M4fzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHVfZZKSzVyPUCuNFMzQTRizszN M3XCb3NCVkeHUh?=
DOHH-2 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7iTFVoUUN3ME2wMlA1QDB|IN88US=> NV2wXYxuW0GQR1XS
HuO9 NEPFVZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEW0OFgh|ryP NHzJUG9USU6JRWK=
EB2 NFXMd2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEW1O|Yh|ryP MlS3V2FPT0WU
G-402 NIjBWoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M136cGlEPTB;MD6wOlM1OSEQvF2= MoLrV2FPT0WU
SU-DHL-1 MkjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzadIdKSzVyPUCuNFY{PzlizszN MkfJV2FPT0WU
NCI-H719 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjPTWM2OD1yLkC3PFg5KM7:TR?= MmX2V2FPT0WU
MLMA M1H2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEmwOkDPxE1? NUWzN2ljW0GQR1XS
KM12 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\sTmlEPTB;MD6wPVc{PyEQvF2= NYq0O|RDW0GQR1XS
SUP-T1 NFHJW|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHaTWM2OD1yLkC5PVgzKM7:TR?= M371eXNCVkeHUh?=
MZ1-PC M{DyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDXSmRKSzVyPUCuNVE{OzZizszN MnLBV2FPT0WU
MFE-296 NVPXUVJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDRUoM5UUN3ME2wMlEyQDN7IN88US=> NV36RXRUW0GQR1XS
ALL-PO Mn3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMUK0OFMh|ryP NYHtWFdxW0GQR1XS
GB-1 NWrPV|hVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXK3OXM5UUN3ME2wMlEzPTF{IN88US=> NX7iNlNjW0GQR1XS
SIG-M5 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMUOzO{DPxE1? MWXTRW5ITVJ?
P30-OHK M2SxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILkS|VKSzVyPUCuNVU3PzJizszN Ml3CV2FPT0WU
NCI-H716 NUL4enNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMU[yOlYh|ryP M1TReXNCVkeHUh?=
MPP-89 NVTjcXB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILlSlVKSzVyPUCuNVY6OzNizszN M1;aNnNCVkeHUh?=
SF126 MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMUewOlMh|ryP NF7BempUSU6JRWK=
CTB-1 NH;yXFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fMT2lEPTB;MD6xO|MyPiEQvF2= MXPTRW5ITVJ?
CA46 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPmTWM2OD1yLkG3OFg6KM7:TR?= NGnmOVlUSU6JRWK=
NCI-H520 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjVd5JKSzVyPUCuNVc4OzJizszN MmC3V2FPT0WU
CAL-85-1 Mlu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PiWmlEPTB;MD6xO|kzPyEQvF2= NFrPOYxUSU6JRWK=
NCI-H2342 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;OTWlEPTB;MD6xPFU4PyEQvF2= MUXTRW5ITVJ?
697 M{HnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvnT|NKSzVyPUCuNVg5PzFizszN NFG1[5pUSU6JRWK=
NY MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGyTWM2OD1yLkG5Nlg4KM7:TR?= MVzTRW5ITVJ?
T98G MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HBcGlEPTB;MD6xPVMyQCEQvF2= MVjTRW5ITVJ?
NCI-H1703 NGjQVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\GRndSUUN3ME2wMlE6PjF3IN88US=> NUP5ZpN7W0GQR1XS
NCI-H2087 NHrMbpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;HcZpwUUN3ME2wMlIxPDN7IN88US=> NXLUelIyW0GQR1XS
PF-382 NX\HTIQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrEcnNKSzVyPUCuNlA5PzNizszN MYjTRW5ITVJ?
HCT-116 NVzWZnZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHkTWM2OD1yLkKxNFY6KM7:TR?= NVe1WVVvW0GQR1XS
CAKI-1 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMkG2OlYh|ryP MV3TRW5ITVJ?
CCF-STTG1 NYrhdW1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIq3[VdKSzVyPUCuNlI1PzVizszN NYXUVHdGW0GQR1XS
D-392MG NF7le4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrSb48xUUN3ME2wMlI{OTd5IN88US=> NUe4[45qW0GQR1XS
RT-112 MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMkO3PVUh|ryP M1ixRXNCVkeHUh?=
MES-SA NIXCUZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTEWVVKSzVyPUCuNlQyQDdizszN MXjTRW5ITVJ?
LC-2-ad M4fSXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUS1WlRJUUN3ME2wMlI1OjZ3IN88US=> MVXTRW5ITVJ?
NOS-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;FUmlEPTB;MD6yOFM3PyEQvF2= MmfDV2FPT0WU
NALM-6 Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMkW1OFMh|ryP MmHtV2FPT0WU
TE-15 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTvNlVKSzVyPUCuNlYxQTFizszN NUDscHFWW0GQR1XS
786-0 NW\BeZZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrZfXZyUUN3ME2wMlI3OjJ6IN88US=> NGjHOnBUSU6JRWK=
IST-MES1 NVX3VGRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELaXnNKSzVyPUCuNlY5OjlizszN NGDp[25USU6JRWK=
KYSE-180 Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMk[4PVEh|ryP MV7TRW5ITVJ?
YT NFLuc|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnVW5lmUUN3ME2wMlI3QTd2IN88US=> MWDTRW5ITVJ?
A427 M3\LcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDTTWM2OD1yLkK3NlY1KM7:TR?= M1\mTHNCVkeHUh?=
KYSE-450 NHHtO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HmOWlEPTB;MD6yO|MzQSEQvF2= MojBV2FPT0WU
HuH-7 M1fUVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfIfW56UUN3ME2wMlI4PzZ|IN88US=> NYW1TWw3W0GQR1XS
CAS-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMkizNFMh|ryP NYHITYx1W0GQR1XS
KURAMOCHI MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPhTWM2OD1yLkK4OFE6KM7:TR?= M1XiXHNCVkeHUh?=
ACHN M{POT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DxZWlEPTB;MD6yPVMzOyEQvF2= NILQcm9USU6JRWK=
HGC-27 M37admdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEG5WpFKSzVyPUCuNlk{PTNizszN MYjTRW5ITVJ?
A172 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP4c3NKSzVyPUCuNlk2PzdizszN MULTRW5ITVJ?
SNU-449 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfoNVZKSzVyPUCuNlk6PjRizszN MUDTRW5ITVJ?
SW982 NXfFWlZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fP[WlEPTB;MD6yPVk4QCEQvF2= M{\zdnNCVkeHUh?=
EFO-21 NFqyPGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwM{C0NVEh|ryP MXHTRW5ITVJ?
NCI-H2030 M3H6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PDV2lEPTB;MD6zNVE3PCEQvF2= M{LDcHNCVkeHUh?=
HT-144 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHy4NYNKSzVyPUCuN|EzQCEQvF2= NUWxVHNXW0GQR1XS
MFE-280 MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfqTWM2OD1yLkOxOFU{KM7:TR?= M1nFd3NCVkeHUh?=
SK-LU-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzFS3hQUUN3ME2wMlMyPDZ4IN88US=> MUHTRW5ITVJ?
NCI-H2052 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnwXIxkUUN3ME2wMlMyPDh2IN88US=> NXuy[nBjW0GQR1XS
SK-HEP-1 NV\mW|dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:3TWM2OD1yLkOzN|Y5KM7:TR?= MoKxV2FPT0WU
QIMR-WIL NVryeVNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwM{O0NlQh|ryP NH\PVXZUSU6JRWK=
A2780 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwM{SzNFQh|ryP MWjTRW5ITVJ?
ACN NIHYVoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;aTWM2OD1yLkO0PFc{KM7:TR?= NYrIOW5DW0GQR1XS
BxPC-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[wdGlEPTB;MD6zOFk5QSEQvF2= MYXTRW5ITVJ?
BCPAP MmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1u2UGlEPTB;MD6zOlAxOSEQvF2= NV;seJdqW0GQR1XS
HOP-62 NITHUYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\QNIF3UUN3ME2wMlM3OTB4IN88US=> MVXTRW5ITVJ?
SW1710 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOzTWM2OD1yLkO2OFU2KM7:TR?= NV3yN4VOW0GQR1XS
OPM-2 M3\Qd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLwTWM2OD1yLkO2OFc{KM7:TR?= NGPpbWhUSU6JRWK=
DBTRG-05MG M2r2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwM{iwOVQh|ryP MWPTRW5ITVJ?
SK-MEL-24 NFPwW5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLzTWM2OD1yLkO5O|kyKM7:TR?= MWDTRW5ITVJ?
8305C M135bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jZUWlEPTB;MD6zPVc6OyEQvF2= MWrTRW5ITVJ?
OVCAR-4 M2f6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzQTWM2OD1yLkSxOVg3KM7:TR?= NFvXZ|FUSU6JRWK=
HLE NGDzeoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGzPHhuUUN3ME2wMlQyQDZizszN NEXGVItUSU6JRWK=
NCI-H747 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\oXYZNUUN3ME2wMlQzOTN5IN88US=> MVjTRW5ITVJ?
SW780 NX3kUYxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwNEKzOFYh|ryP MVrTRW5ITVJ?
KYSE-150 NFHQem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv4eXhvUUN3ME2wMlQzPDF3IN88US=> NGPF[mZUSU6JRWK=
H4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLpTWM2OD1yLkSyOFUyKM7:TR?= NXfETWZRW0GQR1XS
SW1088 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:1RmFoUUN3ME2wMlQ1OzlizszN M3TwXnNCVkeHUh?=
SF268 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TiZ2lEPTB;MD60OFg3KM7:TR?= M4n1ZnNCVkeHUh?=
RT4 M2jBWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwNEWxNVEh|ryP M2rKcnNCVkeHUh?=
NCI-H522 M1nFNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwNEWyO{DPxE1? M2rwV3NCVkeHUh?=
LCLC-97TM1 NW\wbHlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LBdWlEPTB;MD60OlE6PSEQvF2= NG[0fGpUSU6JRWK=
CAL-39 NFz6W5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fmTmlEPTB;MD60OlUyQSEQvF2= NEL4S3NUSU6JRWK=
CAL-120 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwNEe2OFMh|ryP NVTVUnRIW0GQR1XS
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KARPAS-45 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13HR2lEPTB;MD60PFk{OyEQvF2= M4jpPHNCVkeHUh?=
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VMRC-RCZ NFjxRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[1TWM2OD1yLkS5PVA1KM7:TR?= MWLTRW5ITVJ?
HOS MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmO1TWM2OD1yLkWwN|Y2KM7:TR?= NInMTVVUSU6JRWK=
MOLT-16 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\UbGlEPTB;MD61NVgxQCEQvF2= NXLiSlZFW0GQR1XS
RPMI-6666 NXu1fWZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjXNHZKSzVyPUCuOVIyOzVizszN NI\scI9USU6JRWK=
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EHEB Mln5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TSVGlEPTB;MD61NlE5OiEQvF2= MYTTRW5ITVJ?
MFH-ino NV[zPIwxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPsZ4RpUUN3ME2wMlUzOzVzIN88US=> M3TuVHNCVkeHUh?=
A4-Fuk MnSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrnOVhFUUN3ME2wMlUzPTJ6IN88US=> M3[5TnNCVkeHUh?=
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MC-CAR M1LRcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fYRWlEPTB;MT61PFY3OyEQvF2= MkPRV2FPT0WU
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LB831-BLC MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\yXpJCUUN3ME2xMlY6QDV2IN88US=> MWLTRW5ITVJ?
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OVCAR-5 Ml32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3oNmtUUUN3ME2xMlkxPjd3IN88US=> Ml;5V2FPT0WU
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GR-ST MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TWdWlEPTB;Mz60OVc{OiEQvF2= MkPMV2FPT0WU
D-247MG M2rETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTNwNEiyOlMh|ryP MnL0V2FPT0WU
TE-8 NI\CVnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\KblNQUUN3ME2zMlQ6OzN|IN88US=> MlPSV2FPT0WU
LS-411N NF\4eXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvkSmNXUUN3ME2zMlQ6Pjl{IN88US=> MWHTRW5ITVJ?
SK-MES-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjxNoJ1UUN3ME2zMlU3PDN|IN88US=> MlPuV2FPT0WU
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LB2241-RCC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjrTWM2OD1|Lk[2NlYh|ryP MnzKV2FPT0WU
PC-14 M2izd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfkTWM2OD1|Lk[2OFM4KM7:TR?= M1LpZXNCVkeHUh?=
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NCI-H1618 M3;2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n0ZWlEPTB;Mz64NVg4PSEQvF2= NHm4XZNUSU6JRWK=
PANC-03-27 M2jMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXaTWM2OD1|LkixPVE3KM7:TR?= M1fPdHNCVkeHUh?=
NCI-H2228 M1PDT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfMfI5KSzVyPUOuPFMyOjZizszN NXfLNZRIW0GQR1XS
CAPAN-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;uU2lkUUN3ME2zMlg4ODB7IN88US=> M{HaNXNCVkeHUh?=
KLE MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jxRmlEPTB;Mz65NFY4KM7:TR?= NGr2fWVUSU6JRWK=
Becker MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm0TWM2OD1|LkmyPFQ6KM7:TR?= NIDDRoZUSU6JRWK=
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D-502MG NGXubHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\GUpc6UUN3ME20MlE3QTl5IN88US=> M1PKZnNCVkeHUh?=
GI-1 NWrvRnh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nTemlEPTB;ND6yPFI6QSEQvF2= MUTTRW5ITVJ?
NCI-H209 NUXW[2RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PZSmlEPTB;ND6zN|c5KM7:TR?= NVTaW3JjW0GQR1XS
SK-OV-3 NUnNNIV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr3TIxWUUN3ME20MlQ5OTR7IN88US=> Mn7TV2FPT0WU
LOUCY MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2O0eWlEPTB;ND60PFQ{OiEQvF2= MmfhV2FPT0WU
NCI-H69 NVixbXh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDMSWJKSzVyPUSuOVE4QTNizszN M4\pNnNCVkeHUh?=
SCC-9 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTRwNUOxO|Ih|ryP M1OzZXNCVkeHUh?=
NCI-H526 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rZSWlEPTB;ND61PVI6OyEQvF2= MljxV2FPT0WU
NCI-H2170 NV2wNpJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjIUYxKUUN3ME20MlY3PzdzIN88US=> NW\IV2x4W0GQR1XS
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CMK NYTwW|BiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH3N4FKUUN3ME20MlczOTBzIN88US=> MXvTRW5ITVJ?
COLO-829 NWDWSopmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHlNJdKSzVyPUSuO|cxPDNizszN MnTMV2FPT0WU
HuO-3N1 MlzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTRwOEOyPFEh|ryP M{Th[HNCVkeHUh?=
5637 NV\OWXV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomzTWM2OD12LkmwOFg4KM7:TR?= MnG1V2FPT0WU
A253 MoHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHOTWM2OD12Lkm3O|A5KM7:TR?= MWfTRW5ITVJ?
NB10 M2\Fcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfCe4lnUUN3ME21MlA4PDl5IN88US=> MVjTRW5ITVJ?
SF539 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrXVlNKSzVyPUWuNFk6PTlizszN MnPVV2FPT0WU
HAL-01 MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHuS3pKSzVyPUWuNVQ3PDVizszN NEe4XJVUSU6JRWK=
MHH-ES-1 M1PnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjRcVJuUUN3ME21MlE3QTJ3IN88US=> MoLXV2FPT0WU
DEL NGTnSpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXqN5ZxUUN3ME21MlI4PTh{IN88US=> MnfpV2FPT0WU
NCI-H1299 MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7nTWM2OD13LkO1NFA4KM7:TR?= M2i1cHNCVkeHUh?=
ChaGo-K-1 NWTpdXdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1G0NGlEPTB;NT6zOVExPyEQvF2= MnvQV2FPT0WU
HMV-II NF;uXmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTVwM{m0N{DPxE1? MXTTRW5ITVJ?
NB69 M1PIcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2S3V2lEPTB;NT6zPVY{OSEQvF2= MWjTRW5ITVJ?
NCI-H1882 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrsZ4hVUUN3ME21MlQ{OzZ2IN88US=> MWLTRW5ITVJ?
SNU-475 NV;ER49YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfuTWM2OD13LkS3NVcyKM7:TR?= MX;TRW5ITVJ?
RXF393 MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjPTWM2OD13LkS4OFk1KM7:TR?= NXzsdWF[W0GQR1XS
CAL-51 NUXZco9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWyflJKSzVyPUWuOlI5PTNizszN MX3TRW5ITVJ?
SW1573 MlT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rB[2lEPTB;NT62N|U{PCEQvF2= NV2ydo1MW0GQR1XS
GCT NYfIPFhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTVwN{W5Nlkh|ryP M1jCfnNCVkeHUh?=
COR-L88 MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTVwN{[4OFYh|ryP NVXP[XFnW0GQR1XS
MDA-MB-134-VI NGLlNYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTVwOEe1N|Yh|ryP M{\DTXNCVkeHUh?=
NB5 NFLmV5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLLNmFuUUN3ME21MlkzPDRizszN M1j0NnNCVkeHUh?=
GMS-10 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jHeGlEPTB;NT65Olg3OSEQvF2= NFnsR3BUSU6JRWK=
CHP-212 M{LmZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTZwNEiyOlch|ryP M3L5b3NCVkeHUh?=
TE-11 M3eyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTZwNUWxPFIh|ryP NEDUO3JUSU6JRWK=
SW962 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;iSo1vUUN3ME22MlY2Pzd2IN88US=> MnyzV2FPT0WU
MZ2-MEL MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\vV2lEPTB;Nj64NlAyOSEQvF2= NVHFSZdsW0GQR1XS
C-33-A MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTZwOUG2PFgh|ryP NFW4eI5USU6JRWK=
IGR-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTZwOUe4NlYh|ryP MWrTRW5ITVJ?
MOLT-4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3wZVRKSzVyPUeuNVU1ODZizszN NV61[plHW0GQR1XS
NCI-H1650 MnzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFewcGVKSzVyPUeuNlcxPDZizszN NHfR[WpUSU6JRWK=
AsPC-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTdwMki2NFUh|ryP MVnTRW5ITVJ?
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SW620 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K1UWlEPTB;Nz6zPFIxPSEQvF2= NIjyS3RUSU6JRWK=
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TE-6 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33UZmlEPTB;Nz60OFkxQCEQvF2= NHX6S5pUSU6JRWK=
D-263MG MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXraXYZVUUN3ME23MlQ2PzZ{IN88US=> M2rUeHNCVkeHUh?=
NCI-H1355 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7jTWM2OD15Lke3NFI6KM7:TR?= Mo[2V2FPT0WU
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GCIY M4PK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[wTWM2OD1{NT6yPFc4KM7:TR?= MknFV2FPT0WU
NUGC-3 Ml7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4q4OGlEPTB;MkWuN|MyPiEQvF2= M3;US3NCVkeHUh?=
LNCaP-Clone-FGC NVXCO5U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\4SGlEPTB;MkWuN|Q6QCEQvF2= M2q5S3NCVkeHUh?=
PA-1 M2\xU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4joPWlEPTB;MkWuOlg{OyEQvF2= NEnMUoZUSU6JRWK=
OE33 NH3Q[VRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJ3Lk[4OVMh|ryP M4G2OXNCVkeHUh?=
HT-29 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJ3Lke4O|kh|ryP MnThV2FPT0WU
RCM-1 MnTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJ3Lkm2OVYh|ryP MXzTRW5ITVJ?
NCI-H1522 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLreXdKUUN3ME2yOU46QTFzIN88US=> NGrCfZpUSU6JRWK=
LB373-MEL-D MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJ4LkG3NFgh|ryP NXjlSG1mW0GQR1XS
NCI-H1436 MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTYbFdKSzVyPUK2MlI4OzhizszN M2LofnNCVkeHUh?=
COLO-824 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\JdGlEPTB;Mk[uOFAxOiEQvF2= NIXhdHNUSU6JRWK=
CP50-MEL-B MkX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPjTWM2OD1{Nj61Olc2KM7:TR?= NIPESpJUSU6JRWK=
EGI-1 MkD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[0VG1KSzVyPUK3MlI3QThizszN M4fOZnNCVkeHUh?=
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JVM-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJ5Lk[2NlIh|ryP MYLTRW5ITVJ?
UACC-257 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD6SYhKSzVyPUK3MlY5PzhizszN NYHHN2NQW0GQR1XS
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RL NX25Z4pyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJ6LkW5NVEh|ryP M{H4[3NCVkeHUh?=
TK10 M1frV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\VTWM2OD1{OD62OVM2KM7:TR?= NVn3XY9WW0GQR1XS
HT55 NVuxSGFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJ7LkC1OlUh|ryP MlTmV2FPT0WU
BT-20 M1PXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHISYpKSzVyPUK5MlA2QDZizszN NFfXXIdUSU6JRWK=
TGBC24TKB NIXVRYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXnTWM2OD1{OT6xPFMyKM7:TR?= NETFVmdUSU6JRWK=
HSC-2 NFPKNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHsWGZCUUN3ME2yPU4{ODBzIN88US=> NVfp[YQ3W0GQR1XS
COLO-205 Mn\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:0R3pXUUN3ME2yPU4{QTR2IN88US=> NWPrdGlOW0GQR1XS
GT3TKB M4PhUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD3SZplUUN3ME2yPU43QDd5IN88US=> M4nuRnNCVkeHUh?=
T47D NEL5N3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojTTWM2OD1{OT64OVgzKM7:TR?= MnTIV2FPT0WU
OMC-1 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHrWZlRUUN3ME2zNE4yQTF7IN88US=> NHH3fWlUSU6JRWK=
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NCI-H64 NIr4OlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPzd3NNUUN3ME2zNk41OTd7IN88US=> MX;TRW5ITVJ?
DMS-114 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX4WZVUUUN3ME2zNk41OTh{IN88US=> NHjtWVNUSU6JRWK=
NCI-H661 M1W1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rGPGlEPTB;M{KuOlUxOSEQvF2= MnHyV2FPT0WU
CAL-148 NEHZfWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Pm[WlEPTB;M{KuOlY3PSEQvF2= M4W5fXNCVkeHUh?=
HuP-T3 M4SyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPSZWZWUUN3ME2zNk46OzN6IN88US=> NW[x[GVuW0GQR1XS
ES4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfaTWM2OD1|Mz6xO|A2KM7:TR?= M{XwVXNCVkeHUh?=
Ca9-22 NXm5U29CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPGXndKSzVyPUOzMlQ3ODFizszN MnXvV2FPT0WU
LP-1 NXLoWZNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfYWWNKSzVyPUO0MlA6KM7:TR?= MmjwV2FPT0WU
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MDA-MB-453 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M171[WlEPTB;M{WuNVQzPiEQvF2= NIfDWnBUSU6JRWK=
SNU-C1 M4nSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTN3LkG3NUDPxE1? NYXNbXVwW0GQR1XS
SW13 NIfYVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTN3LkSwO|Yh|ryP M33nRnNCVkeHUh?=
NCI-H2122 NGrPc|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILYOmlKSzVyPUO1MlU2QThizszN Mnv3V2FPT0WU
NCI-H1395 NFLSWFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTN3Lk[2PVEh|ryP NVnF[mF[W0GQR1XS
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COR-L279 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTaU5NKSzVyPUO2MlE6QDFizszN MmnuV2FPT0WU
ATN-1 M1TCSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHQS2lKSzVyPUO2Mlg2OTZizszN Mn6zV2FPT0WU
HCC2998 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17MWWlEPTB;M{[uPFU4OSEQvF2= MVzTRW5ITVJ?
UM-UC-3 NInLWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;N[GlEPTB;M{[uPFY4PSEQvF2= MWjTRW5ITVJ?
DV-90 MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXCTWM2OD1|Nj65NFY4KM7:TR?= NYnxSmxsW0GQR1XS
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HCC1599 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW2NmxKSzVyPUO3MlE3OThizszN Mn;LV2FPT0WU
UMC-11 NV[xXJJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTN5LkK1NFMh|ryP M3XMW3NCVkeHUh?=
THP-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:4TWM2OD1|Nz6yPFY5KM7:TR?= MYLTRW5ITVJ?
OCUB-M M{XuOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LqeGlEPTB;M{euNlg6OSEQvF2= MoHqV2FPT0WU
NCI-H1693 NWXSS5FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PIcGlEPTB;M{euN|I{OyEQvF2= MXPTRW5ITVJ?
NCI-H345 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rXR2lEPTB;M{euN|YzPCEQvF2= NWfpcph3W0GQR1XS
COLO-800 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\Fdo1KSzVyPUO3MlU3PyEQvF2= NGPiZpRUSU6JRWK=
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NCI-H596 M1PaRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\vZWlKSzVyPUO4MlQ1QDlizszN NES0fGhUSU6JRWK=
NCI-H187 NGq5e5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILXPZpKSzVyPUO4Mlc{PDRizszN MmGzV2FPT0WU
ECC4 NFTvTIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfkNmxKSzVyPUO5MlA5OTRizszN NHOxPW9USU6JRWK=
KP-4 NXXKXGFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTN7LkGyN|Uh|ryP NGDDbYpUSU6JRWK=
NCI-H2227 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVThNIlPUUN3ME2zPU4{QTR7IN88US=> MknsV2FPT0WU
22RV1 M{PwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTN7LkizPVgh|ryP Mn21V2FPT0WU
SAS NIixXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTVWWx7UUN3ME20NE4xQTZizszN NXHyN41MW0GQR1XS
PANC-10-05 NIPKR5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO3WGFJUUN3ME20NE4yQDJ6IN88US=> MljDV2FPT0WU
MDA-MB-468 NHjCVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzkTWM2OD12MD61N|Q3KM7:TR?= NYPEenNtW0GQR1XS
RPMI-7951 M331UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vRbmlEPTB;NEGuNlA4PSEQvF2= NE\iVFVUSU6JRWK=
BB49-HNC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7LOox1UUN3ME20NU4zOTd7IN88US=> NVz3bXFQW0GQR1XS
23132-87 NXuwSY84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTRzLkK3N|Ih|ryP NGPiZm1USU6JRWK=
HCC1569 M2HiOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTRzLkK4PFUh|ryP NYSyRVBnW0GQR1XS
CP66-MEL NH;ZPYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TUWGlEPTB;NEKuNVg5PiEQvF2= NWjaXohQW0GQR1XS
K-562 NYm1UJhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vKdmlEPTB;NEKuNlg2PCEQvF2= MoLhV2FPT0WU
OCI-AML2 MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfJNo9wUUN3ME20Nk45QTd2IN88US=> NYf5dWtOW0GQR1XS
SW756 MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rWVWlEPTB;NEOuNFM5QCEQvF2= Mk\KV2FPT0WU
M14 M{T3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmyXYV5UUN3ME20N{4{OTh7IN88US=> NGrufHVUSU6JRWK=
NCI-H1623 NE\DbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTR|LkS2OEDPxE1? MoX5V2FPT0WU
KNS-81-FD MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHYTWM2OD12Mz63OlIh|ryP MkKyV2FPT0WU
TGBC1TKB NWnvV3d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPQTWM2OD12Mz65NFk6KM7:TR?= Mm\lV2FPT0WU
RERF-LC-MS NWrjUYRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHBXWpEUUN3ME20N{46OjhzIN88US=> NYLpZmIxW0GQR1XS
PC-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTR2LkSzOFch|ryP NETWdYVUSU6JRWK=
HuP-T4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknUTWM2OD12ND60OFc1KM7:TR?= NG\xeVlUSU6JRWK=
NCI-H510A M{PHUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\lflZKSzVyPUS0MlcxQCEQvF2= NYDaNHJnW0GQR1XS
LB2518-MEL NETXb25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n0d2lEPTB;NESuO|k{PyEQvF2= NXvRTGp3W0GQR1XS
TE-5 NYHBZoFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HT[WlEPTB;NEWuPVU5OSEQvF2= MXLTRW5ITVJ?
EW-24 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrCTWM2OD12Nj6xO|I{KM7:TR?= NYDPWmJKW0GQR1XS
LB647-SCLC NYfmR4M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDhSVNKSzVyPUS2MlIyPTVizszN NUf4VFJVW0GQR1XS
NCI-H524 M3vSZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:3TWM2OD12Nj63NVg2KM7:TR?= MVXTRW5ITVJ?
EW-11 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLIRpJKSzVyPUS2Mlk{PzNizszN Mmq5V2FPT0WU
KALS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv2O3NoUUN3ME20O{4zODZ4IN88US=> MnzPV2FPT0WU
BT-474 NUjOdYU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjRTWM2OD12Nz60NlE3KM7:TR?= MWjTRW5ITVJ?
SK-N-AS M{XMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PLe2lEPTB;NEeuPFg5KM7:TR?= M1fVOXNCVkeHUh?=
HCC2157 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T0ZWlEPTB;NEiuNFc3KM7:TR?= NFTvNWtUSU6JRWK=
HCC1954 NFLYeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDX[JFDUUN3ME20PE4yPzB2IN88US=> NFvD[FJUSU6JRWK=
FADU M333[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;U[GlEPTB;NEiuN|A{OSEQvF2= MlLJV2FPT0WU
S-117 MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2S2eWlEPTB;NEiuN|gyPSEQvF2= NHi4OIRUSU6JRWK=
LS-1034 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTR6LkewOlch|ryP MlnHV2FPT0WU
CAMA-1 NHjxS2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfa[W83UUN3ME20PU42PTR|IN88US=> MVzTRW5ITVJ?
LU-134-A NUOwRXc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TH[2lEPTB;NEmuPFA5PSEQvF2= M3Pre3NCVkeHUh?=
NCI-H1838 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPjPXhKSzVyPUS5MlgxQDdizszN MnfqV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]
臨床試験 AP24534 is currently under Phase II clinical trials in treatment with leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Peptide substrate phosphorylation assays with GST-Abl kinase domains The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.

細胞アッセイ: [2]

細胞株 Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
濃度 0-625 nM
反応時間 72 hours
実験の流れ Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat

動物実験: [1]

動物モデル Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
製剤 Dissolved in 25 mM citrate buffer, pH 2.75
投薬量 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
投与方法 Oral gavage once daily

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download Ponatinib (AP24534) SDF
分子量 532.56
化学式

C29H27F3N6O

CAS No. 943319-70-8
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 30 mg/mL (56.33 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 3-(2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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Frequently Asked Questions

  • Question 1
    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

    Answer: Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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