ABT-263 (Navitoclax) 化学構造
分子量: 974.61

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製品説明

  • Compare Bcl-2 Inhibitors
    Bcl-2製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 ABT-263(Navitoclax)は、 Bcl-xLBcl-2Bcl-w の強力な阻害剤で、Kiがそれぞれ ≤ 0.5 nM、≤1 nM 、≤ 1 nMです。
ターゲット

Bcl-xL

Bcl-2

Bcl-w

IC50

≤ 0.5 nM (Ki)

≤1 nM (Ki)

≤ 1 nM (Ki)[1]

In vitro試験 ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. [1] A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell M1jhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{naW2lEPTB;MD6wNFY3QSEQvF2= NEPxUoJUSU6JRWK=
MV-4-11 M1LTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK0TWM2OD1yLkCxOVg3KM7:TR?= NIHpT4tUSU6JRWK=
NKM-1 NVLhcW9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTLTWM2OD1yLkCxOlk6KM7:TR?= MnnqV2FPT0WU
ML-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrJR5RKSzVyPUCuNFE6QDNizszN MXHTRW5ITVJ?
BV-173 MoO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL3TWM2OD1yLkCyN|E1KM7:TR?= NIXLbY9USU6JRWK=
RS4-11 NG\DdFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvCdnRJUUN3ME2wMlAzPTh5IN88US=> M1jqdHNCVkeHUh?=
HL-60 M1fXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTNTWM2OD1yLkCyPVA5KM7:TR?= NYDlfnJoW0GQR1XS
KY821 M1zvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\nTpFGUUN3ME2wMlAzQTd3IN88US=> M13BSXNCVkeHUh?=
ECC10 NV74VolLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jIRmlEPTB;MD6wN|c6OiEQvF2= MULTRW5ITVJ?
NCI-H720 M{K4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnKNVNqUUN3ME2wMlA1ODFzIN88US=> NV7WW|ZkW0GQR1XS
QIMR-WIL MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMESyPFch|ryP MUnTRW5ITVJ?
KG-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMES0PFYh|ryP NHPtWZpUSU6JRWK=
TGW M2W2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMES2N|Mh|ryP M3HTWnNCVkeHUh?=
ATN-1 M2rK[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3tS2NKSzVyPUCuNFQ4OzNizszN M3fXe3NCVkeHUh?=
RH-18 MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHERnJKSzVyPUCuNFYxPDhizszN M3rnTnNCVkeHUh?=
EW-18 NVeydJI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\GWGlEPTB;MD6wOlg1OSEQvF2= MV;TRW5ITVJ?
NB17 NUXrUWlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHvXVFKSzVyPUCuNFcyOjRizszN NUDRXGtnW0GQR1XS
SK-NEP-1 NUjFfG5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e5UWlEPTB;MD6wO|IyOyEQvF2= NVf5PZJ1W0GQR1XS
P12-ICHIKAWA NF7ER3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnnclRKSzVyPUCuNFc4PzhizszN MkHmV2FPT0WU
KARPAS-45 NED3TmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3OVlBbUUN3ME2wMlA4QDF3IN88US=> MUXTRW5ITVJ?
EW-3 M3zqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEK5PY9KSzVyPUCuNFgxPTNizszN NUf0c4E4W0GQR1XS
NB13 NH36XFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TFZWlEPTB;MD6wPFIxOyEQvF2= NUfXS4htW0GQR1XS
NCI-H209 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PkS2lEPTB;MD6wPFcxPCEQvF2= MXvTRW5ITVJ?
NCI-H1092 NHjLbZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXrN|JKSzVyPUCuNVAzPzVizszN NVH2XmxRW0GQR1XS
NH-12 NHvDcGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW3TWM2OD1yLkGwO|Q1KM7:TR?= M4n0bnNCVkeHUh?=
697 NWnoXI5HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnHWXE{UUN3ME2wMlExQDN7IN88US=> M{nQR3NCVkeHUh?=
KE-37 NWOxW2xIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nPTmlEPTB;MD6xNVM4KM7:TR?= MYrTRW5ITVJ?
MOLT-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXpcJM1UUN3ME2wMlE2OTZ7IN88US=> NGDzTGxUSU6JRWK=
CHP-134 MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r6d2lEPTB;MD6xOlMxPiEQvF2= NYK3WXVWW0GQR1XS
D-283MED NXrVW3hST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TKfmlEPTB;MD6xO|Y5PiEQvF2= M{fMSnNCVkeHUh?=
LU-135 NYPHbWVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMUi1OVIh|ryP NYjp[FV{W0GQR1XS
LU-134-A MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7RTWM2OD1yLkG4OlcyKM7:TR?= M3zLN3NCVkeHUh?=
EM-2 MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMUm5NVgh|ryP MmTMV2FPT0WU
LU-139 MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfRNJpKSzVyPUCuNlA1QThizszN NXi2O|FGW0GQR1XS
ALL-PO NIrC[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPJNWFWUUN3ME2wMlIyQTh6IN88US=> M1;MenNCVkeHUh?=
NB12 NF7Qc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMkOxNVUh|ryP MoGxV2FPT0WU
KP-N-YN MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMkO1O|Mh|ryP MoTqV2FPT0WU
BEN NEfnVI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfwfVBKSzVyPUCuNlM6PjhizszN MonDV2FPT0WU
HCC1569 NGDsTHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnUTWM2OD1yLkK1NVA3KM7:TR?= NX;idlI{W0GQR1XS
HuO9 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMk[3NVUh|ryP MUnTRW5ITVJ?
WM-115 NHn2OZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PXTGlEPTB;MD6yO|c{QCEQvF2= NHO1NoJUSU6JRWK=
CCRF-CEM MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwM{O1Nlkh|ryP NGXYUIRUSU6JRWK=
IST-SL1 M1\EOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfnfIlKSzVyPUCuN|U{PDNizszN NIixdlNUSU6JRWK=
BE-13 NXvWfFRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq2e5ZKSzVyPUCuN|Y1PTlizszN MlT0V2FPT0WU
COR-L88 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXS0T2xxUUN3ME2wMlM3PTRizszN M3vxZnNCVkeHUh?=
DOHH-2 NHf3RYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\NWGlEPTB;MD60NVAzOyEQvF2= MlPYV2FPT0WU
A704 NYG0PJhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfuN|ZKSzVyPUCuOFI3PyEQvF2= Mm\DV2FPT0WU
KNS-81-FD M4C3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SwdGlEPTB;MD60OFAyPyEQvF2= NH3ye|RUSU6JRWK=
RPMI-8226 NIezdWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLRTWM2OD1yLkS1OlUzKM7:TR?= MXHTRW5ITVJ?
TGBC24TKB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwNEW3O|gh|ryP NIrwRWtUSU6JRWK=
NCI-H1304 MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXITWM2OD1yLkS2NVU4KM7:TR?= MUjTRW5ITVJ?
MOLT-13 NHziRZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSzTWM2OD1yLkS2OlE{KM7:TR?= NGnFNYZUSU6JRWK=
EW-22 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nGWGlEPTB;MD60OlY4OSEQvF2= NXjMRWt4W0GQR1XS
MS-1 MojTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfRTWM2OD1yLkS2PVM{KM7:TR?= NHzHd3hUSU6JRWK=
RMG-I NET4W3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33kXWlEPTB;MD60PVQ3PCEQvF2= NFnkZ4pUSU6JRWK=
NTERA-S-cl-D1 NUjEUHY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nJNmlEPTB;MD61NFAyQSEQvF2= Ml;tV2FPT0WU
NCI-H1048 M4P4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf3TWM2OD1yLkWwPVU{KM7:TR?= NXvwNnlDW0GQR1XS
SW1417 NIjVdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwNUW0N|gh|ryP MmLyV2FPT0WU
DB M2PqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPUZY1KSzVyPUCuOVcxQCEQvF2= MkDqV2FPT0WU
MEG-01 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXTZpF2UUN3ME2wMlU5OzJizszN NVqyU4pCW0GQR1XS
EW-13 NWizSnd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPXTWM2OD1yLkW4N|QyKM7:TR?= NUD5[JdWW0GQR1XS
LAMA-84 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLDWlBKSzVyPUCuOVkzODdizszN NEXkbXdUSU6JRWK=
J-RT3-T3-5 MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwNkC4NFgh|ryP MYDTRW5ITVJ?
MOLT-16 M1S2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1v3V2lEPTB;MD62OVI3PCEQvF2= NV;J[JRsW0GQR1XS
DU-4475 NXHN[XVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwNkW0Nlch|ryP MXHTRW5ITVJ?
HAL-01 NXjDdGtDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLpTlVKSzVyPUCuO|I2PDlizszN NUTkWZlKW0GQR1XS
RD NYnGdJBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDzTWM2OD1yLke1PFk6KM7:TR?= M3ro[3NCVkeHUh?=
OAW-28 M4ToRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwN{izO{DPxE1? M1;PVHNCVkeHUh?=
HCC38 Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrQUm9KSzVyPUCuPFAyQSEQvF2= NU\S[VY{W0GQR1XS
NMC-G1 MkP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwOEGxNlEh|ryP MnrPV2FPT0WU
EW-16 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4njTWlEPTB;MD64NVMzQCEQvF2= NVvHWY9iW0GQR1XS
DU-145 M3\5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzSTWM2OD1yLki5PVI{KM7:TR?= Moi1V2FPT0WU
HPAF-II NYTBe2ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwOUK2Nlgh|ryP NV3BNpFLW0GQR1XS
A427 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwOUOwNlIh|ryP NEPvWWJUSU6JRWK=
PA-1 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXUemxGUUN3ME2wMlk2PjR{IN88US=> M4jtUXNCVkeHUh?=
OAW-42 NHjxUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1GzNmlEPTB;MD65OlE1PiEQvF2= M2DTZnNCVkeHUh?=
L-428 MnjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK2TWM2OD1zLkCxNlUh|ryP NGXYTYxUSU6JRWK=
COLO-824 M2\YNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPzXJRVUUN3ME2xMlAyPzB6IN88US=> NIfFd2hUSU6JRWK=
P30-OHK MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrMTWM2OD1zLkC0Olg5KM7:TR?= MoHPV2FPT0WU
NCI-H2170 NFfJdoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluxTWM2OD1zLkC2NlMh|ryP M3vYUXNCVkeHUh?=
HCC2998 M{HaZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX3TWM2OD1zLkC3NVM2KM7:TR?= NWDYWFh2W0GQR1XS
NB14 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\nS25oUUN3ME2xMlE{PzR6IN88US=> MoTMV2FPT0WU
TGBC1TKB MmiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHCboJKSzVyPUGuNVQyPTJizszN NGnxZWRUSU6JRWK=
KP-N-YS MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwMU[yN|Yh|ryP M1HacHNCVkeHUh?=
CAL-120 NFvNTo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[0Z3dKSzVyPUGuNVY1OjlizszN M4TFdHNCVkeHUh?=
SBC-1 MkDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfBTWM2OD1zLkG5NFU{KM7:TR?= NVS5VHlpW0GQR1XS
C32 NVjhVGt5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFwMUmwPFgh|ryP M1jMZ3NCVkeHUh?=
HCC2157 MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETOfXdKSzVyPUGuNVk1QTRizszN MlHpV2FPT0WU
COLO-792 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jpUmlEPTB;MT6yNFA4OSEQvF2= NX3XcJA4W0GQR1XS
ES7 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrIV4hKSzVyPUGuNlc6PTFizszN NYrlNHoyW0GQR1XS
HEL NFi3RW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTFwM{GwNlkh|ryP MlnuV2FPT0WU
ES4 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jOZmlEPTB;MT6zOFk6QCEQvF2= MnvyV2FPT0WU
NCI-SNU-1 NXXkcJNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj4TWM2OD1zLkO2OVU2KM7:TR?= M1;kSnNCVkeHUh?=
MDA-MB-415 NUjX[ZNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHmyfFJKSzVyPUGuN|g5PSEQvF2= MXXTRW5ITVJ?
NCI-H2342 NILpXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPEVFBtUUN3ME2xMlQxOjZ7IN88US=> MXrTRW5ITVJ?
NB69 NVWwVm9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1u1eGlEPTB;MT60OlI4OSEQvF2= MmXKV2FPT0WU
D-247MG MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf5UVJKSzVyPUGuOVEyOjJizszN MX;TRW5ITVJ?
SCC-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjxTWM2OD1zLkW5PFg4KM7:TR?= MX3TRW5ITVJ?
HuH-7 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTQRnFIUUN3ME2xMlY4Ojl|IN88US=> NWfPdFNKW0GQR1XS
A388 Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHR[FNKSzVyPUGuOlg4OjRizszN NFvBN3NUSU6JRWK=
Calu-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3qTWM2OD1zLkewOlk4KM7:TR?= M3TMc3NCVkeHUh?=
NCI-H1648 MmXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwN{G0NVgh|ryP NWfRcINEW0GQR1XS
NCI-H2052 M1TVXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTFwN{KyNFEh|ryP NIL6ZWtUSU6JRWK=
Ramos-2G6-4C10 NGjCTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknmTWM2OD1zLkezOlU3KM7:TR?= MX\TRW5ITVJ?
DEL MoDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTj[ZBKSzVyPUGuO|Q3QTJizszN MV;TRW5ITVJ?
SNU-423 NYDndlZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonTTWM2OD1zLke4NVU4KM7:TR?= NWXieXV[W0GQR1XS
COR-L23 MnSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\tTJpKSzVyPUGuO|k5PzRizszN NHTIZllUSU6JRWK=
OMC-1 NWjDdGk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwOE[wNVYh|ryP MV;TRW5ITVJ?
EW-11 NH7JWlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LvRWlEPTB;MT65OVY2PyEQvF2= NVrOVGd3W0GQR1XS
HSC-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DUUWlEPTB;MT65OlM3PSEQvF2= NF;pUmZUSU6JRWK=
MLMA MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTFwOU[2O|ch|ryP NV3MWmx5W0GQR1XS
RCM-1 NHP6cGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HoVmlEPTB;Mj6wNFM6QSEQvF2= NX;pb|RLW0GQR1XS
MFE-280 M4PndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnjVItWUUN3ME2yMlAzQDR6IN88US=> NGDGfVJUSU6JRWK=
ES8 NE\6VZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJwMkW0O|Eh|ryP NFThcIhUSU6JRWK=
TE-11 Mmi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTJwMkm0O|Mh|ryP MnTjV2FPT0WU
HuO-3N1 M4jxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7ZOIxWUUN3ME2yMlQ5PzhizszN MUHTRW5ITVJ?
MHH-NB-11 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorCTWM2OD1{LkWxNVU5KM7:TR?= MnX1V2FPT0WU
TGBC11TKB NWTyWHRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJwNUe2PFEh|ryP MXLTRW5ITVJ?
HOP-92 M2jnVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS4TGpKSzVyPUKuOVg4PDNizszN Mn;0V2FPT0WU
IGR-1 NYX2V|hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJwNkKwN|Uh|ryP MYLTRW5ITVJ?
GOTO MlfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C0SWlEPTB;Mj62OVM4PyEQvF2= NUnQVYkzW0GQR1XS
NCI-H1650 MlTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTu[3pKSzVyPUKuO|IzOTVizszN MWTTRW5ITVJ?
NCI-H1581 M3TlWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nTR2lEPTB;Mj63PVY5OSEQvF2= MWHTRW5ITVJ?
NCI-H2405 NEf5XGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\PRXR5UUN3ME2yMlgzPzh{IN88US=> M{PnOnNCVkeHUh?=
U-118-MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrWN2ZKSzVyPUKuPVY1QTFizszN NF7kXnZUSU6JRWK=
DoTc2-4510 M3\jfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i5SWlEPTB;Mz6wNVQyPyEQvF2= MYPTRW5ITVJ?
NCI-H596 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rmc2lEPTB;Mz6wOFk6PyEQvF2= MYjTRW5ITVJ?
MPP-89 Moi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPnVplKSzVyPUOuNFU3PjZizszN NH:yOoVUSU6JRWK=
GCIY M1Ozd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInJZ5hKSzVyPUOuNlA1QTFizszN MlLvV2FPT0WU
SW626 M32xRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTNwMkS1OFMh|ryP MVHTRW5ITVJ?
OCI-AML2 NVf2OFlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi1V5hTUUN3ME2zMlMyOjd{IN88US=> M{fYXnNCVkeHUh?=
NBsusSR NGHNSo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fOemlEPTB;Mz6zOFk{QCEQvF2= NHvwRYVUSU6JRWK=
AN3-CA MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTNwNESyN|gh|ryP MlnTV2FPT0WU
EFM-19 NUP0SlFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnNZpZKSzVyPUOuOFg{OzlizszN NGfCTIRUSU6JRWK=
RVH-421 M2L3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfJTWM2OD1|LkW2PFc4KM7:TR?= NX3LfIl1W0GQR1XS
5637 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDlTWM2OD1|Lk[xNVA{KM7:TR?= MXrTRW5ITVJ?
PANC-08-13 NWmxSVJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNwNkO0O|Ih|ryP M{i2PXNCVkeHUh?=
H9 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\o[o54UUN3ME2zMlY4OTR2IN88US=> NYHiXHZWW0GQR1XS
KARPAS-299 M3SxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnf5TWM2OD1|Lk[3N|YyKM7:TR?= MXXTRW5ITVJ?
TE-5 NGPieo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTNwN{C3NFkh|ryP MXTTRW5ITVJ?
NOS-1 NHr3bmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[1U2lEPTB;Mz63PVg{PCEQvF2= NXvlXXA6W0GQR1XS
HH NFzoclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHpTJFKSzVyPUOuPFM5PjhizszN NHfsPVFUSU6JRWK=
769-P M1LTOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;BTWM2OD1|Lki5OVEh|ryP NIToSllUSU6JRWK=
CHP-212 M4T3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmSxTWM2OD1|LkmyOVQ6KM7:TR?= M1qzPHNCVkeHUh?=
NCI-H82 NIHS[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvrTWM2OD1|Lkm1PVM3KM7:TR?= MXvTRW5ITVJ?
Mo-T MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HS[mlEPTB;ND6wOFMyOiEQvF2= NWH2VpdrW0GQR1XS
BB65-RCC MkPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;jbFBOUUN3ME20MlA1Ozl7IN88US=> Mm\hV2FPT0WU
SW1990 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTRwMEW5NFgh|ryP MYTTRW5ITVJ?
LK-2 MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTRwMUGyPVMh|ryP NVTxN4JMW0GQR1XS
ES5 MonoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV75bYg3UUN3ME20MlE{QTh3IN88US=> MoP1V2FPT0WU
JVM-3 NUPDNG9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr2PWVoUUN3ME20MlE5OjJ{IN88US=> MmWyV2FPT0WU
RPMI-7951 NVTwbo9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[wWWlEPTB;ND6yNlQyOyEQvF2= NG\T[FZUSU6JRWK=
Calu-6 NWL1dVh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTRwMke4PFEh|ryP NVPnUHREW0GQR1XS
LC-2-ad MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TPe2lEPTB;ND6yPVU3QCEQvF2= Ml;aV2FPT0WU
SW954 MnHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LITGlEPTB;ND6yPVY3KM7:TR?= NH[zd4xUSU6JRWK=
H-EMC-SS MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvFTWM2OD12LkOxPFMyKM7:TR?= M4\1d3NCVkeHUh?=
ES3 MorCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTRwM{W0OFEh|ryP NFvsfGFUSU6JRWK=
no-11 NGHZUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzoTWM2OD12LkO1OVU1KM7:TR?= M1vPfHNCVkeHUh?=
LAN-6 M{PjU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXTSppvUUN3ME20MlQ2OTh7IN88US=> M3S2ZnNCVkeHUh?=
FTC-133 M3zJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HOT2lEPTB;ND61N|k2KM7:TR?= MWrTRW5ITVJ?
8505C M2nEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXCNY9LUUN3ME20MlU1OjNizszN MnfBV2FPT0WU
SW620 Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XS[2lEPTB;ND61O|A2PyEQvF2= MVPTRW5ITVJ?
BCPAP MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTRwNkO0PFEh|ryP M1HDOHNCVkeHUh?=
SK-LU-1 NU\rU2diT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq4eI9YUUN3ME20MlY3ODh7IN88US=> NWnoRo5TW0GQR1XS
NCI-H1623 NX\keo97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTRwN{CyNlgh|ryP NFTlcXdUSU6JRWK=
C2BBe1 M1;5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\kUWduUUN3ME20Mlc1ODB6IN88US=> MoXZV2FPT0WU
GP5d MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PJdWlEPTB;ND63PFM5QCEQvF2= MYDTRW5ITVJ?
NB6 MnvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H5NGlEPTB;ND64OlIxPCEQvF2= MmHFV2FPT0WU
MDA-MB-157 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nWbmlEPTB;ND64PFc3KM7:TR?= MmTDV2FPT0WU
UMC-11 M1nVV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW2OnZJUUN3ME20Mlg5QTZ2IN88US=> NHvOSndUSU6JRWK=
HCC1419 NV;ydpdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTRwOUCwOlMh|ryP MXTTRW5ITVJ?
NCI-H2029 M1jGR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvtTWM2OD12Lkm0NVg2KM7:TR?= M13kd3NCVkeHUh?=
LXF-289 NGHNeXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;CWIV6UUN3ME21MlA{PzF7IN88US=> NFj1eHZUSU6JRWK=
KINGS-1 NGP6c2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTVwMEe3OFQh|ryP NGrhbHBUSU6JRWK=
HD-MY-Z M{XBd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrzd3lKSzVyPUWuNlM6PjlizszN Mkn0V2FPT0WU
ESS-1 M2fCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTVwMkW1PVch|ryP M1\oTHNCVkeHUh?=
GI-1 M3HXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7ocmJ2UUN3ME21MlI4QTJ4IN88US=> MkS4V2FPT0WU
RPMI-2650 NEjqNGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTVwM{[xOkDPxE1? MX\TRW5ITVJ?
IA-LM MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTVwM{m4O|Eh|ryP NIDnOG1USU6JRWK=
KP-4 MlnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorGTWM2OD13LkS2N|M1KM7:TR?= NFSzXWNUSU6JRWK=
G-402 NXrIfYVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[1colKSzVyPUWuOVE5PjVizszN M2LS[3NCVkeHUh?=
OS-RC-2 M4DPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrkTWM2OD13LkWyOlA1KM7:TR?= NYfxV3BMW0GQR1XS
NCI-H1155 M2nwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XQeGlEPTB;NT61OFk2PSEQvF2= MVTTRW5ITVJ?
OE19 M4\2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml2yTWM2OD13Lk[4OlI1KM7:TR?= Mmj3V2FPT0WU
U-2-OS MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH6TWM2OD13Lki5NFE{KM7:TR?= MnHwV2FPT0WU
SCC-15 NYTlS4Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4L2dmlEPTB;NT65N|Y3OiEQvF2= MnXSV2FPT0WU
NCI-H630 NWjEOmFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mke5TWM2OD13Lkm5OFA1KM7:TR?= NEj0ZoxUSU6JRWK=
PFSK-1 NFi4VoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\5cnVKSzVyPU[uNFUzPTlizszN MoPnV2FPT0WU
NCI-H1770 MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf4TY9KSzVyPU[uNlA5PzRizszN M3W0WXNCVkeHUh?=
SK-MEL-3 M1HYSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\RVGlEPTB;Nj60NlkyPSEQvF2= Ml[4V2FPT0WU
LB1047-RCC M{LjR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTaTWM2OD14LkS3OlI2KM7:TR?= MorJV2FPT0WU
NCI-H446 NX\hSo1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTZwNkK5NlUh|ryP NY\zVXJFW0GQR1XS
SW780 M{D6R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkm2TWM2OD14LkewNVg2KM7:TR?= M3G0fHNCVkeHUh?=
NEC8 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTZwN{[2N{DPxE1? MWTTRW5ITVJ?
NOMO-1 M2j4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGGy[opKSzVyPU[uO|gyOTFizszN MoHkV2FPT0WU
COLO-668 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfXPZRKSzVyPU[uPFQ{QDdizszN NI[5bY9USU6JRWK=
MC116 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTZwOUO4PVch|ryP NEXmfFlUSU6JRWK=
HCC1937 NXvHco53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nMTWlEPTB;Nj65PVI2OSEQvF2= M{Lx[HNCVkeHUh?=
NCI-N87 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHoTWM2OD15LkG5Nlk{KM7:TR?= NWLCU2J{W0GQR1XS
COLO-320-HSR MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4S3WGlEPTB;Nz6yNlc{QCEQvF2= MXnTRW5ITVJ?
HCC1806 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnrUpdKSzVyPUeuNlYxPDRizszN M3f4dHNCVkeHUh?=
OVCAR-3 NEG4Z4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHG[YlKSzVyPUeuN|MxOzhizszN M3;oPXNCVkeHUh?=
NUGC-3 NHrmdZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XyNGlEPTB;Nz6zPVY6PCEQvF2= Mn:5V2FPT0WU
SW1783 NIfBWHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\LVXpsUUN3ME23MlQ{OTd3IN88US=> NF20d5VUSU6JRWK=
GCT MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrucmpKSzVyPUeuOVY6ODZizszN MXzTRW5ITVJ?
NCI-H2126 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrNTWM2OD15LkezOlI2KM7:TR?= MoXJV2FPT0WU
MEL-HO Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2w[ZZ5UUN3ME23Mlc4ODV2IN88US=> NF24T|BUSU6JRWK=
CAPAN-1 NXf5O4JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLyUYFKSzVyPUeuO|c{PTdizszN M3TrPHNCVkeHUh?=
SW756 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHSOmFKSzVyPUeuO|g{OzNizszN NVfFZZJoW0GQR1XS
SKG-IIIa M4jWOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTdwOEG4PVIh|ryP Ml;ZV2FPT0WU
HCE-T NIezUpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2KwdWlEPTB;Nz64O|c5OyEQvF2= MmjUV2FPT0WU
Ca-Ski MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:xN|A2UUN3ME23Mlk6Ozh|IN88US=> NYHLXWxNW0GQR1XS
COLO-684 M1Sxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\HVoFKSzVyPUiuNFE5OThizszN M3HrUXNCVkeHUh?=
KYSE-70 NHjPWXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzvenNKSzVyPUiuNFc4OjlizszN M1\CXXNCVkeHUh?=
TI-73 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f6UWlEPTB;OD6yOVg2OSEQvF2= M1LKeXNCVkeHUh?=
BT-20 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XWWmlEPTB;OD6yOlA2OiEQvF2= MXfTRW5ITVJ?
MHH-ES-1 NV\kTJZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj3eYM3UUN3ME24MlUyQDN2IN88US=> Mmr2V2FPT0WU
TE-12 Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fFPGlEPTB;OD61PVk{OSEQvF2= MmPJV2FPT0WU
YH-13 NFLiOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;kTWM2OD16Lk[xNFA5KM7:TR?= NGfCUZVUSU6JRWK=
SF126 NH3DbYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfVTWM2OD16LkizPFY2KM7:TR?= MWnTRW5ITVJ?
J82 M4jESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRThwOUCwN|gh|ryP MUnTRW5ITVJ?
RCC10RGB NIjsW4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRThwOUm1OlEh|ryP MYjTRW5ITVJ?
SK-UT-1 M{TPUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTlwMES5OFUh|ryP MXjTRW5ITVJ?
LB2241-RCC NInXdVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\QfFJKSzVyPUmuNVkyOzdizszN MWjTRW5ITVJ?
LB996-RCC MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi5bJhTUUN3ME25MlE6QDlizszN MYDTRW5ITVJ?
EPLC-272H MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXWWnRlUUN3ME25MlM4PjV5IN88US=> MlLWV2FPT0WU
CTV-1 NGnXU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;VUJJKSzVyPUmuOVY2OzJizszN M1\YWnNCVkeHUh?=
HSC-2 NELwVpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTlwNUe1OUDPxE1? M2fSS3NCVkeHUh?=
SK-MEL-28 M134cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rO[mlEPTB;OT62NVg6OyEQvF2= NFPrOppUSU6JRWK=
MMAC-SF NG\hRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTlwNki3OUDPxE1? MWnTRW5ITVJ?
CP50-MEL-B MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPITWM2OD17Lke1O|gzKM7:TR?= NXK4bJVNW0GQR1XS
HT-1080 MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;1N4tTUUN3ME25Mlc4PzN7IN88US=> M1;HXnNCVkeHUh?=
HEC-1 M3HVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\hTo1KSzVyPUGwMlM{PTJizszN MnnWV2FPT0WU
AGS NEXHS5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TxNGlEPTB;MUCuN|c1KM7:TR?= NH7CVIVUSU6JRWK=
GAMG NWX4[ZdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTFyLkWxOlIh|ryP NHHVcGxUSU6JRWK=
SW48 M37SSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fQN2lEPTB;MUCuOVE5QSEQvF2= M1Tz[XNCVkeHUh?=
U031 NXvSVlVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\mOmlEPTB;MUCuOVkxQCEQvF2= NV[5ZmhlW0GQR1XS
OVCAR-5 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[3TWM2OD1zMD62OFI6KM7:TR?= MmP2V2FPT0WU
SF295 MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlWxTWM2OD1zMD62O|A1KM7:TR?= MonGV2FPT0WU
BHT-101 MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;vb2lEPTB;MUCuO|E4PyEQvF2= Mk\aV2FPT0WU
VMRC-RCZ M33XeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTZfoozUUN3ME2xNU4{OjBzIN88US=> Mn7WV2FPT0WU
ACHN NFnyeWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrNdJFpUUN3ME2xNU41OjFzIN88US=> MXjTRW5ITVJ?
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K5 NFfuV5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPOeFlKSzVyPUS1Mlk1ODVizszN MnrGV2FPT0WU
NCI-H358 NWC3RVdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fRUGlEPTB;NEeuNlE2KM7:TR?= NWfDcYtCW0GQR1XS
NCI-H2030 M1rleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTR5LkKzO|Qh|ryP NHLvd5pUSU6JRWK=
SW948 M3e3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWiwSXJ1UUN3ME20O{41PjRizszN NYH5c2lpW0GQR1XS
BALL-1 Mlv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzqXnJKSzVyPUS3MlYyPjhizszN NVO3UVhDW0GQR1XS
TE-9 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjmTWM2OD12Nz65OVgyKM7:TR?= NVXneZF[W0GQR1XS
SK-N-FI M3TLNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r2WmlEPTB;NEiuNFM2QCEQvF2= NYrHRllFW0GQR1XS
KALS-1 M2nwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mof2TWM2OD12OD6xNlg6KM7:TR?= M2TjS3NCVkeHUh?=
HO-1-N-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTR6Lke0OFUh|ryP MmHOV2FPT0WU
NCI-H2452 M3rmOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTR7LkGxOVIh|ryP M17ZPHNCVkeHUh?=
OC-314 NW\MSFd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q2OmlEPTB;NEmuOlg{PCEQvF2= MX7TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 When ABT-263 is administered at 100 mg/kg/day in the H345 xenograft model, significant antitumor efficacy is observed with 80% TGI and 20% of treated tumors indicating at least a 50% reduction in tumor volume. [2] Oral administration of ABT-263 alone causes complete tumor regressions in xenograft models of small-cell lung cancer and acute lymphoblastic leukemia. In xenograft models of aggressive B-cell lymphoma and multiple myeloma where ABT-263 displays modest or no single agent activity, it significantly enhances the efficacy of clinically relevant therapeutic regimens. [2]
臨床試験 ABT-263 is currently in Phase II clinical trial for the treatments of chronic lymphocytic leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Affinity determination Binding affinities (Ki or IC50) of ABT-263 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and Bcl-2 (10 nM), f-Bax (1 nM) and Bcl-w (40 nM), f-Noxa (2 nM) and Mcl-1 (40 nM), and f-Bax (1 nM) and Bcl-2-A1 (15 nM). Binding affinities for Bcl-xL are also determined using a time-resolved fluorescence resonance energy transfer assay. Bcl-xL (1 nM, His tagged) is mixed with 200 nM f-Bak, 1 nM Tb-labeled anti-His antibody, and ABT-263 at room temperature for 30 min. Fluorescence is measured on an Envision plate reader using a 340/35 nm excitation filter and 520/525 (f-Bak) and 495/510 nm (Tb-labeled anti-His antibody) emission filters.

細胞アッセイ:

[1]

細胞株 SCLC cell lines
濃度 0-1 μM
反応時間 48 hours
実験の流れ

Human tumor cell lines SCLC cell lines are maintained at 37℃ containing 5% CO2. SCLC cell lines are cultured in RPMI 1640 with 10% fetal bovine serum (FBS), 1% sodium pyruvate, 25 mM HEPES, 4.5 g/L glucose, and 1% penicillin/streptomycin. Leukemia and lymphoma cell lines are cultured in RPMI 1640 supplemented with 10% FBS and 1% penicillin/streptomycin. Cells (1-5×10 4) are treated by ABT-263 for 48 hours in 96-well culture plates in a final volume of 100 μL and cytotoxicity is assessed with the CellTiter Glo assay. In vitro cyto toxicity of ABT-263 is assayed.

動物実験:

[1]

動物モデル C.B.-17 scid-bg or C.B.-17 scid mice
製剤 Formulated in 10% ethanol, 30% polyethylene glycol 400, and 60% Phosal 50 PG
投薬量 100 mg/kg/d
投与方法 Administered via p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download ABT-263 (Navitoclax) SDF
分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS No. 923564-51-6
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 100 mg/mL (102.6 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 5% DMSO+corn oil 7mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4-​[4-​[[2-​(4-​chlorophenyl)​-​5,​5-​dimethyl-​1-​cyclohexen-​1-​yl]​methyl]​-​1-​piperazinyl]​-​N-​[[4-​[[(1R)​-​3-​(4-​morpholinyl)​-​1-​[(phenylthio)​methyl]​propyl]​amino]​-​3-​[(trifluoromethyl)​sulfonyl]​phenyl]​sulfonyl]​-benzamide

文献中の引用 (36)

Frequently Asked Questions

  • Question 1
    Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

    Answer: According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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