ABT-263 (Navitoclax) 化学構造
分子量: 974.61

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製品説明

  • Compare Bcl-2 Inhibitors
    Bcl-2製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 ABT-263(Navitoclax)は、 Bcl-xLBcl-2Bcl-w の強力な阻害剤で、Kiがそれぞれ ≤ 0.5 nM、≤1 nM 、≤ 1 nMです。
ターゲット

Bcl-xL

Bcl-2

Bcl-w

IC50

≤ 0.5 nM (Ki)

≤1 nM (Ki)

≤ 1 nM (Ki)[1]

In vitro試験 ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. [1] A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLqXnFKUUN3ME2wMlAxPjZ7IN88US=> MlHoV2FPT0WU
MV-4-11 NIjwXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\QTWM2OD1yLkCxOVg3KM7:TR?= MkDEV2FPT0WU
NKM-1 M2[0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEG2PVkh|ryP NFO0NZpUSU6JRWK=
ML-2 Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHZTWM2OD1yLkCxPVg{KM7:TR?= M1LOeHNCVkeHUh?=
BV-173 NXi3NnBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fXfGlEPTB;MD6wNlMyPCEQvF2= M{jvbXNCVkeHUh?=
RS4-11 NILCVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV63XoR4UUN3ME2wMlAzPTh5IN88US=> Mn3uV2FPT0WU
HL-60 NGLGZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEK5NFgh|ryP MlPLV2FPT0WU
KY821 MkHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TyfmlEPTB;MD6wNlk4PSEQvF2= Mn6xV2FPT0WU
ECC10 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfnTWM2OD1yLkCzO|kzKM7:TR?= MWjTRW5ITVJ?
NCI-H720 M4roVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljrTWM2OD1yLkC0NFEyKM7:TR?= M4PD[3NCVkeHUh?=
QIMR-WIL M164bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnMXmIyUUN3ME2wMlA1Ojh5IN88US=> M4HP[XNCVkeHUh?=
KG-1 MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLwZW1KSzVyPUCuNFQ1QDZizszN MnTaV2FPT0WU
TGW MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnKeYlKSzVyPUCuNFQ3OzNizszN M1W4cnNCVkeHUh?=
ATN-1 M4HhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMES3N|Mh|ryP NXHkR45XW0GQR1XS
RH-18 M{nUOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwME[wOFgh|ryP NHeyOoVUSU6JRWK=
EW-18 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrncmtKSzVyPUCuNFY5PDFizszN NFLuVmRUSU6JRWK=
NB17 NIPpWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTFTW8yUUN3ME2wMlA4OTJ2IN88US=> M{OydXNCVkeHUh?=
SK-NEP-1 NIXHUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTBR4tpUUN3ME2wMlA4OjF|IN88US=> NVzTZ2x[W0GQR1XS
P12-ICHIKAWA NXjoZ2tRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL0dHJKSzVyPUCuNFc4PzhizszN M2\O[XNCVkeHUh?=
KARPAS-45 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn6TWM2OD1yLkC3PFE2KM7:TR?= NG\vOXhUSU6JRWK=
EW-3 M4PYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\3VHNKSzVyPUCuNFgxPTNizszN MkjmV2FPT0WU
NB13 M1fjXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DZU2lEPTB;MD6wPFIxOyEQvF2= MmXMV2FPT0WU
NCI-H209 M{Xhfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETiWIhKSzVyPUCuNFg4ODRizszN NUHNRoRSW0GQR1XS
NCI-H1092 NFP3O2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPmSmxKSzVyPUCuNVAzPzVizszN NIXzPFNUSU6JRWK=
NH-12 NV7HeFQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfBcFM1UUN3ME2wMlExPzR2IN88US=> MlziV2FPT0WU
697 NWTmUIptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrIRo9KSzVyPUCuNVA5OzlizszN M{DEfXNCVkeHUh?=
KE-37 M1OzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXjTWM2OD1yLkGxN|ch|ryP NWj1fWtXW0GQR1XS
MOLT-4 NFjOPIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMUWxOlkh|ryP MoP6V2FPT0WU
CHP-134 NUjWRmhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33wNWlEPTB;MD6xOlMxPiEQvF2= MVXTRW5ITVJ?
D-283MED MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnxd4lKSzVyPUCuNVc3QDZizszN M1uyO3NCVkeHUh?=
LU-135 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[0SpFKSzVyPUCuNVg2PTJizszN NFfDU41USU6JRWK=
LU-134-A NFPBcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTv[HlDUUN3ME2wMlE5PjdzIN88US=> MkHNV2FPT0WU
EM-2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED1eHBKSzVyPUCuNVk6OThizszN M{HxOHNCVkeHUh?=
LU-139 M4SzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;LTWM2OD1yLkKwOFk5KM7:TR?= MULTRW5ITVJ?
ALL-PO MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2KzUGlEPTB;MD6yNVk5QCEQvF2= MXrTRW5ITVJ?
NB12 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMkOxNVUh|ryP NV[wcGpRW0GQR1XS
KP-N-YN M3nhdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PSN2lEPTB;MD6yN|U4OyEQvF2= MoDLV2FPT0WU
BEN M{WwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXtWWpKSzVyPUCuNlM6PjhizszN M13jdHNCVkeHUh?=
HCC1569 Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j6RWlEPTB;MD6yOVExPiEQvF2= MojNV2FPT0WU
HuO9 NXXQOWc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLNTWM2OD1yLkK2O|E2KM7:TR?= MWXTRW5ITVJ?
WM-115 NVnrXmVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTUPWRKSzVyPUCuNlc4OzhizszN NWfEdphiW0GQR1XS
CCRF-CEM Mk[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3n[ZdxUUN3ME2wMlM{PTJ7IN88US=> M37td3NCVkeHUh?=
IST-SL1 Mon3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG4NVNmUUN3ME2wMlM2OzR|IN88US=> NFXwW|FUSU6JRWK=
BE-13 NWDyXYNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwM{[0OVkh|ryP MnTUV2FPT0WU
COR-L88 NXLnOmd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzFTWM2OD1yLkO2OVQh|ryP NXixXohSW0GQR1XS
DOHH-2 M4T6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DkS2lEPTB;MD60NVAzOyEQvF2= MWDTRW5ITVJ?
A704 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXadXNKSzVyPUCuOFI3PyEQvF2= M3HCZ3NCVkeHUh?=
KNS-81-FD NEXFNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1raNmlEPTB;MD60OFAyPyEQvF2= MUDTRW5ITVJ?
RPMI-8226 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPkUJMyUUN3ME2wMlQ2PjV{IN88US=> MlmzV2FPT0WU
TGBC24TKB NX31[ldET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPPTWM2OD1yLkS1O|c5KM7:TR?= MWLTRW5ITVJ?
NCI-H1304 MnzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn2R3dDUUN3ME2wMlQ3OTV5IN88US=> NIK4N2lUSU6JRWK=
MOLT-13 MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXpTWM2OD1yLkS2OlE{KM7:TR?= M{jXZnNCVkeHUh?=
EW-22 MlzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlmxTWM2OD1yLkS2OlcyKM7:TR?= NVnTWGxJW0GQR1XS
MS-1 M1HBbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwNE[5N|Mh|ryP NHruO|NUSU6JRWK=
RMG-I Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT2WJBKSzVyPUCuOFk1PjRizszN MlX2V2FPT0WU
NTERA-S-cl-D1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwNUCwNVkh|ryP MXHTRW5ITVJ?
NCI-H1048 NUO2VGVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwNUC5OVMh|ryP MkTlV2FPT0WU
SW1417 M{nwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rwemlEPTB;MD61OVQ{QCEQvF2= MUnTRW5ITVJ?
DB NHjnSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r3UGlEPTB;MD61O|A5KM7:TR?= NWrCOYI1W0GQR1XS
MEG-01 M2LySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwNUizNkDPxE1? MY\TRW5ITVJ?
EW-13 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPDbHpzUUN3ME2wMlU5OzRzIN88US=> NXvzWpR3W0GQR1XS
LAMA-84 NFG3enpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rmZ2lEPTB;MD61PVIxPyEQvF2= MX3TRW5ITVJ?
J-RT3-T3-5 NGrx[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXRfJZKSzVyPUCuOlA5ODhizszN MVXTRW5ITVJ?
MOLT-16 Mln0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLITWM2OD1yLk[1NlY1KM7:TR?= NYjFdIRKW0GQR1XS
DU-4475 MmLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnINpJxUUN3ME2wMlY2PDJ5IN88US=> NHeybFhUSU6JRWK=
HAL-01 M2W1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fa[2lEPTB;MD63NlU1QSEQvF2= MkHQV2FPT0WU
RD MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LSd2lEPTB;MD63OVg6QSEQvF2= MnP1V2FPT0WU
OAW-28 MlXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfI[4syUUN3ME2wMlc5OzdizszN NV7re4lHW0GQR1XS
HCC38 Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFviXHFKSzVyPUCuPFAyQSEQvF2= MUTTRW5ITVJ?
NMC-G1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvtXINFUUN3ME2wMlgyOTJzIN88US=> NH3G[nNUSU6JRWK=
EW-16 NXvYVWZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHMTWM2OD1yLkixN|I5KM7:TR?= NWXL[IU3W0GQR1XS
DU-145 M{LJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwOEm5NlMh|ryP M{nIT3NCVkeHUh?=
HPAF-II M1zzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2L5bmlEPTB;MD65NlYzQCEQvF2= MYTTRW5ITVJ?
A427 M4LKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwOUOwNlIh|ryP NEm2XZBUSU6JRWK=
PA-1 NFLRW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XlPWlEPTB;MD65OVY1OiEQvF2= NEH6RmVUSU6JRWK=
OAW-42 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S2V2lEPTB;MD65OlE1PiEQvF2= NYW4V4FJW0GQR1XS
L-428 NWnwdndGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\DTWM2OD1zLkCxNlUh|ryP NVvwfIZuW0GQR1XS
COLO-824 NFXTS5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17wSWlEPTB;MT6wNVcxQCEQvF2= NIXVUnBUSU6JRWK=
P30-OHK MmPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfHTWM2OD1zLkC0Olg5KM7:TR?= M4HmVXNCVkeHUh?=
NCI-H2170 M4fIb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:zTWM2OD1zLkC2NlMh|ryP NIriVVRUSU6JRWK=
HCC2998 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvrVHJKSzVyPUGuNFcyOzVizszN NU\4WpNjW0GQR1XS
NB14 NE\EcnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nHV2lEPTB;MT6xN|c1QCEQvF2= M4m2ZXNCVkeHUh?=
TGBC1TKB MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzKW496UUN3ME2xMlE1OTV{IN88US=> M1HpcHNCVkeHUh?=
KP-N-YS MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHHTWM2OD1zLkG2NlM3KM7:TR?= M{LlOnNCVkeHUh?=
CAL-120 MoPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\nRWlEPTB;MT6xOlQzQSEQvF2= MoXHV2FPT0WU
SBC-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXS4e2R2UUN3ME2xMlE6ODV|IN88US=> M1TQVnNCVkeHUh?=
C32 NIq3SVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\Bb49OUUN3ME2xMlE6ODh6IN88US=> NE\YeGlUSU6JRWK=
HCC2157 NGfPV5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTFwMUm0PVQh|ryP M1HMTXNCVkeHUh?=
COLO-792 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO4NGxVUUN3ME2xMlIxODdzIN88US=> NV;ufWd3W0GQR1XS
ES7 M3:3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnwTWM2OD1zLkK3PVUyKM7:TR?= MmC2V2FPT0WU
HEL MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPJTWM2OD1zLkOxNFI6KM7:TR?= NF;TZXdUSU6JRWK=
ES4 MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr1OlZpUUN3ME2xMlM1QTl6IN88US=> NXvWSFhVW0GQR1XS
NCI-SNU-1 NGnMdXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFwM{[1OVUh|ryP NWfuOItLW0GQR1XS
MDA-MB-415 M1mxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTFwM{i4OUDPxE1? NVjQO3J6W0GQR1XS
NCI-H2342 M4joSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\jZWhKSzVyPUGuOFAzPjlizszN MVLTRW5ITVJ?
NB69 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfXTWM2OD1zLkS2NlcyKM7:TR?= MUTTRW5ITVJ?
D-247MG MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFwNUGxNlIh|ryP NYiwcI0xW0GQR1XS
SCC-4 M1Hi[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVn1dXV{UUN3ME2xMlU6QDh5IN88US=> MmXzV2FPT0WU
HuH-7 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn3d3dKSzVyPUGuOlczQTNizszN MlK0V2FPT0WU
A388 NUWw[nJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwNki3NlQh|ryP MUnTRW5ITVJ?
Calu-3 Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFwN{C2PVch|ryP NXrXbI5SW0GQR1XS
NCI-H1648 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvKTZZKSzVyPUGuO|E1OThizszN MoPsV2FPT0WU
NCI-H2052 NEXNeYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIP5[lFKSzVyPUGuO|IzODFizszN NGHUUplUSU6JRWK=
Ramos-2G6-4C10 MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfOTWM2OD1zLkezOlU3KM7:TR?= NXTh[HNsW0GQR1XS
DEL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfIeZNKSzVyPUGuO|Q3QTJizszN NY\EbVRFW0GQR1XS
SNU-423 NFiyO3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTFwN{ixOVch|ryP MnfLV2FPT0WU
COR-L23 NU\KSFdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfVRlFxUUN3ME2xMlc6QDd2IN88US=> MYnTRW5ITVJ?
OMC-1 NWH3PIlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnMV5lFUUN3ME2xMlg3ODF4IN88US=> M1PyZ3NCVkeHUh?=
EW-11 M4LnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTFwOUW2OVch|ryP NXzofotZW0GQR1XS
HSC-3 NUm2WXhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\sTWM2OD1zLkm2N|Y2KM7:TR?= MULTRW5ITVJ?
MLMA MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIizV41KSzVyPUGuPVY3PzdizszN MlnoV2FPT0WU
RCM-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHxXFYzUUN3ME2yMlAxOzl7IN88US=> NGr1TJZUSU6JRWK=
MFE-280 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwMEK4OFgh|ryP NV7PRY1wW0GQR1XS
ES8 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYizT5NCUUN3ME2yMlI2PDdzIN88US=> M4r2enNCVkeHUh?=
TE-11 NF6zWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7GTWM2OD1{LkK5OFc{KM7:TR?= MYjTRW5ITVJ?
HuO-3N1 NWnmNXRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jxTWlEPTB;Mj60PFc5KM7:TR?= MX3TRW5ITVJ?
MHH-NB-11 NEPpc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy1dnpKSzVyPUKuOVEyPThizszN MUnTRW5ITVJ?
TGBC11TKB NYT3SHlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLkTnUxUUN3ME2yMlU4PjhzIN88US=> NWrWWGUzW0GQR1XS
HOP-92 NXfGPHg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvXTWM2OD1{LkW4O|Q{KM7:TR?= Mn7hV2FPT0WU
IGR-1 NGXaZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJwNkKwN|Uh|ryP M1;iTXNCVkeHUh?=
GOTO NV7IeWE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\0bWlEPTB;Mj62OVM4PyEQvF2= NEPaRYVUSU6JRWK=
NCI-H1650 NGryOVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPWTWM2OD1{LkeyNlE2KM7:TR?= NWPib5R6W0GQR1XS
NCI-H1581 MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkO0TWM2OD1{Lke5OlgyKM7:TR?= MlzyV2FPT0WU
NCI-H2405 M1\uSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJwOEK3PFIh|ryP NU[2fm1PW0GQR1XS
U-118-MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3hNGRjUUN3ME2yMlk3PDlzIN88US=> MYLTRW5ITVJ?
DoTc2-4510 NUP3WGpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTNwMEG0NVch|ryP NIWydppUSU6JRWK=
NCI-H596 MkLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnaR4ZKSzVyPUOuNFQ6QTdizszN NV;uSG5bW0GQR1XS
MPP-89 M1rtTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTKTWM2OD1|LkC1OlY3KM7:TR?= NYjIdm9wW0GQR1XS
GCIY Ml\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TYOmlEPTB;Mz6yNFQ6OSEQvF2= MYXTRW5ITVJ?
SW626 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnwWZE5UUN3ME2zMlI1PTR|IN88US=> NHrMWHNUSU6JRWK=
OCI-AML2 M4LkSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7tSJhWUUN3ME2zMlMyOjd{IN88US=> NUOwdmpoW0GQR1XS
NBsusSR M1nvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTNwM{S5N|gh|ryP M1K5OXNCVkeHUh?=
AN3-CA M3HUXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWS1c|ZSUUN3ME2zMlQ1OjN6IN88US=> M1zyenNCVkeHUh?=
EFM-19 M3Hsemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rTZmlEPTB;Mz60PFM{QSEQvF2= M2XP[3NCVkeHUh?=
RVH-421 M1zYcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTNwNU[4O|ch|ryP M2jMS3NCVkeHUh?=
5637 Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPMc45bUUN3ME2zMlYyOTB|IN88US=> NW[5fVRWW0GQR1XS
PANC-08-13 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\vTWM2OD1|Lk[zOFczKM7:TR?= NHrsboFUSU6JRWK=
H9 M1nxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXNTWM2OD1|Lk[3NVQ1KM7:TR?= MVPTRW5ITVJ?
KARPAS-299 NXfmVok1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jXT2lEPTB;Mz62O|M3OSEQvF2= M3\3dHNCVkeHUh?=
TE-5 NHex[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXKTWM2OD1|LkewO|A6KM7:TR?= NFm2RnVUSU6JRWK=
NOS-1 NHfUSHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTNwN{m4N|Qh|ryP M1fWV3NCVkeHUh?=
HH MoHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\ZTJlKSzVyPUOuPFM5PjhizszN MkfDV2FPT0WU
769-P NHW4cpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3ZbXdKSzVyPUOuPFk2OSEQvF2= MUfTRW5ITVJ?
CHP-212 MkLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL0W4JyUUN3ME2zMlkzPTR7IN88US=> M4X4OHNCVkeHUh?=
NCI-H82 MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW1VYk1UUN3ME2zMlk2QTN4IN88US=> NFPlPVlUSU6JRWK=
Mo-T NGfZcXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTRwMESzNVIh|ryP Ml7uV2FPT0WU
BB65-RCC M{XLW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T3eGlEPTB;ND6wOFM6QSEQvF2= NXzUb25uW0GQR1XS
SW1990 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rUOmlEPTB;ND6wOVkxQCEQvF2= M2PSNHNCVkeHUh?=
LK-2 M2PCcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3JT2tKSzVyPUSuNVEzQTNizszN NXTVb3d3W0GQR1XS
ES5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTRwMUO5PFUh|ryP MoHBV2FPT0WU
JVM-3 NV;DS2tyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3IbJdKSzVyPUSuNVgzOjJizszN M3jPWXNCVkeHUh?=
RPMI-7951 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33MWGlEPTB;ND6yNlQyOyEQvF2= MXHTRW5ITVJ?
Calu-6 NYjPT4lHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[3Z2h1UUN3ME20MlI4QDhzIN88US=> MoDqV2FPT0WU
LC-2-ad MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXrWZJKSzVyPUSuNlk2PjhizszN NVrxfoM3W0GQR1XS
SW954 M4TVV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTRwMkm2OkDPxE1? M3TKfXNCVkeHUh?=
H-EMC-SS M3LTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELvcW9KSzVyPUSuN|E5OzFizszN MXHTRW5ITVJ?
ES3 NVziOFFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nIeGlEPTB;ND6zOVQ1OSEQvF2= M1nFUXNCVkeHUh?=
no-11 NW\2WppGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq1ToVnUUN3ME20MlM2PTV2IN88US=> NHXkNIhUSU6JRWK=
LAN-6 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXlTWM2OD12LkS1NVg6KM7:TR?= Ml;UV2FPT0WU
FTC-133 NUL0[IFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;HcIZKUUN3ME20MlU{QTVizszN NXTMd4FNW0GQR1XS
8505C MojlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrxWIcxUUN3ME20MlU1OjNizszN NYPZ[WpFW0GQR1XS
SW620 MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3m5NWlEPTB;ND61O|A2PyEQvF2= NYTCNJBSW0GQR1XS
BCPAP MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHNbFJzUUN3ME20MlY{PDhzIN88US=> NHHJdHNUSU6JRWK=
SK-LU-1 MkOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXJTWM2OD12Lk[2NFg6KM7:TR?= NXfOcpVuW0GQR1XS
NCI-H1623 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPMTWM2OD12LkewNlI5KM7:TR?= M4jVbXNCVkeHUh?=
C2BBe1 NYDRcpVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzi[25oUUN3ME20Mlc1ODB6IN88US=> Mkj1V2FPT0WU
GP5d NFXZdI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\rTWM2OD12Lke4N|g5KM7:TR?= NUPJfYlOW0GQR1XS
NB6 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTRwOE[yNFQh|ryP Mke0V2FPT0WU
MDA-MB-157 M4WwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TVbGlEPTB;ND64PFc3KM7:TR?= MWTTRW5ITVJ?
UMC-11 NIi5U4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTRwOEi5OlQh|ryP NInnUFRUSU6JRWK=
HCC1419 NXXiNpAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRwOUCwOlMh|ryP NFjpb4JUSU6JRWK=
NCI-H2029 MnLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTRwOUSxPFUh|ryP NGPpcGVUSU6JRWK=
LXF-289 NEH3NG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHpWm5qUUN3ME21MlA{PzF7IN88US=> NH7OUFFUSU6JRWK=
KINGS-1 Ml\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H2R2lEPTB;NT6wO|c1PCEQvF2= NF3kbHlUSU6JRWK=
HD-MY-Z MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLOTWM2OD13LkKzPVY6KM7:TR?= NX7xSIk{W0GQR1XS
ESS-1 M3LTN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[3TWM2OD13LkK1OVk4KM7:TR?= MoL4V2FPT0WU
GI-1 MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTVwMke5NlYh|ryP NIK4WppUSU6JRWK=
RPMI-2650 NVrVTopZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXVRXdbUUN3ME21MlM3OTZizszN Mn3lV2FPT0WU
IA-LM NHP3NopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlriTWM2OD13LkO5PFcyKM7:TR?= M1nt[XNCVkeHUh?=
KP-4 NXj5c4F[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHLZ2NSUUN3ME21MlQ3OzN2IN88US=> M4X4PXNCVkeHUh?=
G-402 Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTVwNUG4OlUh|ryP MWnTRW5ITVJ?
OS-RC-2 Ml[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFS4e4xKSzVyPUWuOVI3ODRizszN MWPTRW5ITVJ?
NCI-H1155 NWXKcW11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTVwNUS5OVUh|ryP NIfGfWtUSU6JRWK=
OE19 NX3zc|dVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK4TWM2OD13Lk[4OlI1KM7:TR?= MkG2V2FPT0WU
U-2-OS MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPsO|A6UUN3ME21Mlg6ODF|IN88US=> NXnXUoJRW0GQR1XS
SCC-15 NX\XW|BGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf2[5lvUUN3ME21Mlk{PjZ{IN88US=> MWnTRW5ITVJ?
NCI-H630 M33Jfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS0[FEyUUN3ME21Mlk6PDB2IN88US=> NVjSXlV7W0GQR1XS
PFSK-1 Mmi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTZwMEWyOVkh|ryP M4PJRXNCVkeHUh?=
NCI-H1770 NHLDRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\xSYpIUUN3ME22MlIxQDd2IN88US=> MXjTRW5ITVJ?
SK-MEL-3 NXH0[4xHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP2W3NKSzVyPU[uOFI6OTVizszN MYfTRW5ITVJ?
LB1047-RCC NEDxPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEWzVY9KSzVyPU[uOFc3OjVizszN NGXGdWhUSU6JRWK=
NCI-H446 MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTZwNkK5NlUh|ryP M33mdHNCVkeHUh?=
SW780 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv4[nBKSzVyPU[uO|AyQDVizszN MYjTRW5ITVJ?
NEC8 MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jieGlEPTB;Nj63OlY{KM7:TR?= NI\ONpFUSU6JRWK=
NOMO-1 NHf4NmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnuZWtKSzVyPU[uO|gyOTFizszN M3mwcnNCVkeHUh?=
COLO-668 M2jRRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXoTWM2OD14Lki0N|g4KM7:TR?= M1jWT3NCVkeHUh?=
MC116 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X6ZmlEPTB;Nj65N|g6PyEQvF2= MoTHV2FPT0WU
HCC1937 NET6[G9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vSWGlEPTB;Nj65PVI2OSEQvF2= NH\QUGhUSU6JRWK=
NCI-N87 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M336N2lEPTB;Nz6xPVI6OyEQvF2= MnLyV2FPT0WU
COLO-320-HSR MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rEU2lEPTB;Nz6yNlc{QCEQvF2= M{TtTnNCVkeHUh?=
HCC1806 NUKyN4Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPiZVY3UUN3ME23MlI3ODR2IN88US=> MV7TRW5ITVJ?
OVCAR-3 NE\EPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHWTWM2OD15LkOzNFM5KM7:TR?= NEjsWWlUSU6JRWK=
NUGC-3 MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[3V|hKSzVyPUeuN|k3QTRizszN M4nBPXNCVkeHUh?=
SW1783 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDZTWM2OD15LkSzNVc2KM7:TR?= NGDkfG1USU6JRWK=
GCT M17FcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHldGdKSzVyPUeuOVY6ODZizszN MV;TRW5ITVJ?
NCI-H2126 NF3BcYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrVepdKSzVyPUeuO|M3OjVizszN MUHTRW5ITVJ?
MEL-HO NXHvbmNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfBfmlJUUN3ME23Mlc4ODV2IN88US=> Mn30V2FPT0WU
CAPAN-1 NXG0b|RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2WzSWlEPTB;Nz63O|M2PyEQvF2= M{PPbHNCVkeHUh?=
SW756 M2f4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\URWJKSzVyPUeuO|g{OzNizszN M2nVV3NCVkeHUh?=
SKG-IIIa NXHyUoRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXSZo17UUN3ME23MlgyQDl{IN88US=> MVrTRW5ITVJ?
HCE-T M33xcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3hVZNKSzVyPUeuPFc4QDNizszN MUfTRW5ITVJ?
Ca-Ski NWH2fo16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDzTWM2OD15Lkm5N|g{KM7:TR?= Ml\OV2FPT0WU
COLO-684 Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Tsc2lEPTB;OD6wNVgyQCEQvF2= MUHTRW5ITVJ?
KYSE-70 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFyzb|RKSzVyPUiuNFc4OjlizszN M1TIbnNCVkeHUh?=
TI-73 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfJTWM2OD16LkK1PFUyKM7:TR?= MmDyV2FPT0WU
BT-20 M1zRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHNXnNKSzVyPUiuNlYxPTJizszN M{LsWHNCVkeHUh?=
MHH-ES-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rrT2lEPTB;OD61NVg{PCEQvF2= NUDYfGZSW0GQR1XS
TE-12 NH\Jc|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DXVWlEPTB;OD61PVk{OSEQvF2= M{PkTHNCVkeHUh?=
YH-13 MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHTTWM2OD16Lk[xNFA5KM7:TR?= MojMV2FPT0WU
SF126 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjnc3hKSzVyPUiuPFM5PjVizszN NX74OFFyW0GQR1XS
J82 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf4emFKSzVyPUiuPVAxOzhizszN M1fu[3NCVkeHUh?=
RCC10RGB MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRThwOUm1OlEh|ryP NEHDZlFUSU6JRWK=
SK-UT-1 NX3ob2JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHtXHlHUUN3ME25MlA1QTR3IN88US=> M1vFd3NCVkeHUh?=
LB2241-RCC NYm2XYRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTlwMUmxN|ch|ryP M{LXZXNCVkeHUh?=
LB996-RCC NHX4bHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zHb2lEPTB;OT6xPVg6KM7:TR?= NEnFdZdUSU6JRWK=
EPLC-272H MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vVb2lEPTB;OT6zO|Y2PyEQvF2= MXzTRW5ITVJ?
CTV-1 NWPvdVBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTlwNU[1N|Ih|ryP M2PPWnNCVkeHUh?=
HSC-2 NWfvbW0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjhXnRKSzVyPUmuOVc2PSEQvF2= M{SxVXNCVkeHUh?=
SK-MEL-28 MkDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTlwNkG4PVMh|ryP Ml\tV2FPT0WU
MMAC-SF NGDpb5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jWRWlEPTB;OT62PFc2KM7:TR?= MXzTRW5ITVJ?
CP50-MEL-B NGHhOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTlwN{W3PFIh|ryP MofmV2FPT0WU
HT-1080 NEDzXHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi5O3lKSzVyPUmuO|c4OzlizszN MnzIV2FPT0WU
HEC-1 NGjlXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\2emlEPTB;MUCuN|M2OiEQvF2= NWexNopFW0GQR1XS
AGS MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPYVFFJUUN3ME2xNE4{PzRizszN NVL2VFU5W0GQR1XS
GAMG NHHaVIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjFV3VHUUN3ME2xNE42OTZ{IN88US=> MU\TRW5ITVJ?
SW48 NXzKN5E3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3v2XGlEPTB;MUCuOVE5QSEQvF2= NHLGcZRUSU6JRWK=
U031 NGWyTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PkNWlEPTB;MUCuOVkxQCEQvF2= Mn62V2FPT0WU
OVCAR-5 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTFyLk[0Nlkh|ryP M2DvW3NCVkeHUh?=
SF295 NUnDZYNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInZXlBKSzVyPUGwMlY4ODRizszN MWrTRW5ITVJ?
BHT-101 Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LRR2lEPTB;MUCuO|E4PyEQvF2= NFPxdJRUSU6JRWK=
VMRC-RCZ MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX1VmduUUN3ME2xNU4{OjBzIN88US=> NInKWmRUSU6JRWK=
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MCF7 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rydGlEPTB;NEWuOVA2OSEQvF2= NI\uWW9USU6JRWK=
K5 NGLXdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfRNnFIUUN3ME20OU46PDB3IN88US=> NIPQcGVUSU6JRWK=
NCI-H358 NYO5SXpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofSTWM2OD12Nz6yNVUh|ryP NV3S[ldQW0GQR1XS
NCI-H2030 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTR5LkKzO|Qh|ryP NUXJXJM2W0GQR1XS
SW948 NVrEXGNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7TXXlCUUN3ME20O{41PjRizszN MlW2V2FPT0WU
BALL-1 NEHsT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fqfWlEPTB;NEeuOlE3QCEQvF2= NXy0d4xwW0GQR1XS
TE-9 MoPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDNT3VKSzVyPUS3Mlk2QDFizszN MXLTRW5ITVJ?
SK-N-FI NV\RNlhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PwbmlEPTB;NEiuNFM2QCEQvF2= NGi3[pZUSU6JRWK=
KALS-1 M3e1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzqTWM2OD12OD6xNlg6KM7:TR?= NGDhOnpUSU6JRWK=
HO-1-N-1 M1rjcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGThdnVKSzVyPUS4Mlc1PDVizszN NIOxZWpUSU6JRWK=
NCI-H2452 MljXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{WxZmlEPTB;NEmuNVE2OiEQvF2= M3\sfXNCVkeHUh?=
OC-314 NGHXOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC0TWM2OD12OT62PFM1KM7:TR?= M3rjN3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 When ABT-263 is administered at 100 mg/kg/day in the H345 xenograft model, significant antitumor efficacy is observed with 80% TGI and 20% of treated tumors indicating at least a 50% reduction in tumor volume. [2] Oral administration of ABT-263 alone causes complete tumor regressions in xenograft models of small-cell lung cancer and acute lymphoblastic leukemia. In xenograft models of aggressive B-cell lymphoma and multiple myeloma where ABT-263 displays modest or no single agent activity, it significantly enhances the efficacy of clinically relevant therapeutic regimens. [2]
臨床試験 ABT-263 is currently in Phase II clinical trial for the treatments of chronic lymphocytic leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Affinity determination Binding affinities (Ki or IC50) of ABT-263 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and Bcl-2 (10 nM), f-Bax (1 nM) and Bcl-w (40 nM), f-Noxa (2 nM) and Mcl-1 (40 nM), and f-Bax (1 nM) and Bcl-2-A1 (15 nM). Binding affinities for Bcl-xL are also determined using a time-resolved fluorescence resonance energy transfer assay. Bcl-xL (1 nM, His tagged) is mixed with 200 nM f-Bak, 1 nM Tb-labeled anti-His antibody, and ABT-263 at room temperature for 30 min. Fluorescence is measured on an Envision plate reader using a 340/35 nm excitation filter and 520/525 (f-Bak) and 495/510 nm (Tb-labeled anti-His antibody) emission filters.

細胞アッセイ:

[1]

細胞株 SCLC cell lines
濃度 0-1 μM
反応時間 48 hours
実験の流れ

Human tumor cell lines SCLC cell lines are maintained at 37℃ containing 5% CO2. SCLC cell lines are cultured in RPMI 1640 with 10% fetal bovine serum (FBS), 1% sodium pyruvate, 25 mM HEPES, 4.5 g/L glucose, and 1% penicillin/streptomycin. Leukemia and lymphoma cell lines are cultured in RPMI 1640 supplemented with 10% FBS and 1% penicillin/streptomycin. Cells (1-5×10 4) are treated by ABT-263 for 48 hours in 96-well culture plates in a final volume of 100 μL and cytotoxicity is assessed with the CellTiter Glo assay. In vitro cyto toxicity of ABT-263 is assayed.

動物実験:

[1]

動物モデル C.B.-17 scid-bg or C.B.-17 scid mice
製剤 Formulated in 10% ethanol, 30% polyethylene glycol 400, and 60% Phosal 50 PG
投薬量 100 mg/kg/d
投与方法 Administered via p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download ABT-263 (Navitoclax) SDF
分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS No. 923564-51-6
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 100 mg/mL (102.6 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 5% DMSO+corn oil 7mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4-​[4-​[[2-​(4-​chlorophenyl)​-​5,​5-​dimethyl-​1-​cyclohexen-​1-​yl]​methyl]​-​1-​piperazinyl]​-​N-​[[4-​[[(1R)​-​3-​(4-​morpholinyl)​-​1-​[(phenylthio)​methyl]​propyl]​amino]​-​3-​[(trifluoromethyl)​sulfonyl]​phenyl]​sulfonyl]​-benzamide

文献中の引用 (36)

Frequently Asked Questions

  • Question 1
    Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

    Answer: According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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