ABT-263 (Navitoclax) 化学構造
分子量: 974.61

高品質保証

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カスタマーフィードバック(13)

Quality Control & MSDS

製品説明

  • Compare Bcl-2 Inhibitors
    Bcl-2製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 ABT-263(Navitoclax)は、 Bcl-xLBcl-2Bcl-w の強力な阻害剤で、Kiがそれぞれ ≤ 0.5 nM、≤1 nM 、≤ 1 nMです。
ターゲット

Bcl-xL

Bcl-2

Bcl-w

IC50

≤ 0.5 nM (Ki)

≤1 nM (Ki)

≤ 1 nM (Ki)[1]

In vitro試験 ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. [1] A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell NIftZWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq1TWM2OD1yLkCwOlY6KM7:TR?= MVPTRW5ITVJ?
MV-4-11 NVXjb2NUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXyXoVKSzVyPUCuNFE2QDZizszN MlHiV2FPT0WU
NKM-1 M{XoNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPZdYx7UUN3ME2wMlAyPjl7IN88US=> M4DpNnNCVkeHUh?=
ML-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrMTWM2OD1yLkCxPVg{KM7:TR?= MkPxV2FPT0WU
BV-173 M3qzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1uxcGlEPTB;MD6wNlMyPCEQvF2= MXHTRW5ITVJ?
RS4-11 M1HrVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;XTWM2OD1yLkCyOVg4KM7:TR?= MXvTRW5ITVJ?
HL-60 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMEK5NFgh|ryP NXfvbJhXW0GQR1XS
KY821 M4jCb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEK5O|Uh|ryP M3zGS3NCVkeHUh?=
ECC10 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NImyeJZKSzVyPUCuNFM4QTJizszN MmO1V2FPT0WU
NCI-H720 MnnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMESwNVEh|ryP MXjTRW5ITVJ?
QIMR-WIL MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHTN2pKSzVyPUCuNFQzQDdizszN NFPzdHhUSU6JRWK=
KG-1 NXnqb3ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMES0PFYh|ryP MVXTRW5ITVJ?
TGW NEHJbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHWTWM2OD1yLkC0OlM{KM7:TR?= NUXFfXBqW0GQR1XS
ATN-1 Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMES3N|Mh|ryP M{nZRnNCVkeHUh?=
RH-18 M1;5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwME[wOFgh|ryP M3\McnNCVkeHUh?=
EW-18 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j3cmlEPTB;MD6wOlg1OSEQvF2= MVjTRW5ITVJ?
NB17 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPYTWM2OD1yLkC3NVI1KM7:TR?= MWfTRW5ITVJ?
SK-NEP-1 NY\5TlNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEeyNVMh|ryP NFfE[mdUSU6JRWK=
P12-ICHIKAWA M1nSOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUeyO441UUN3ME2wMlA4Pzd6IN88US=> MXnTRW5ITVJ?
KARPAS-45 M1n5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmftTWM2OD1yLkC3PFE2KM7:TR?= MXrTRW5ITVJ?
EW-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLpTWM2OD1yLkC4NFU{KM7:TR?= MlTOV2FPT0WU
NB13 MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojyTWM2OD1yLkC4NlA{KM7:TR?= MWDTRW5ITVJ?
NCI-H209 NGfWN3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEi3NFQh|ryP NGLOOVNUSU6JRWK=
NCI-H1092 M{\l[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4juZWlEPTB;MD6xNFI4PSEQvF2= NYXqbXI5W0GQR1XS
NH-12 NIDPOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLOTWM2OD1yLkGwO|Q1KM7:TR?= M33JXHNCVkeHUh?=
697 NV7YSZNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPBeWJKSzVyPUCuNVA5OzlizszN NIHUdJNUSU6JRWK=
KE-37 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMUGzO{DPxE1? MWLTRW5ITVJ?
MOLT-4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G5O2lEPTB;MD6xOVE3QSEQvF2= NH7YVHVUSU6JRWK=
CHP-134 NYHsV2dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXGTWM2OD1yLkG2N|A3KM7:TR?= MWrTRW5ITVJ?
D-283MED NGe1Zo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfUTWM2OD1yLkG3Olg3KM7:TR?= MlHpV2FPT0WU
LU-135 M4jrcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rOTGlEPTB;MD6xPFU2OiEQvF2= MmXwV2FPT0WU
LU-134-A NILXUWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe5SJR6UUN3ME2wMlE5PjdzIN88US=> MkjPV2FPT0WU
EM-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HGUmlEPTB;MD6xPVkyQCEQvF2= NHP4[FBUSU6JRWK=
LU-139 NXH3W4trT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TLO2lEPTB;MD6yNFQ6QCEQvF2= Mm\3V2FPT0WU
ALL-PO MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfMVIJKSzVyPUCuNlE6QDhizszN MknoV2FPT0WU
NB12 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMkOxNVUh|ryP MXjTRW5ITVJ?
KP-N-YN M1LvcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\BTWM2OD1yLkKzOVc{KM7:TR?= NIjEZ4pUSU6JRWK=
BEN NGW0SpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL4c3ZKSzVyPUCuNlM6PjhizszN M3PqNnNCVkeHUh?=
HCC1569 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMkWxNFYh|ryP MYnTRW5ITVJ?
HuO9 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMk[3NVUh|ryP Mlj5V2FPT0WU
WM-115 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHQS|hKSzVyPUCuNlc4OzhizszN NXv2b41VW0GQR1XS
CCRF-CEM M3XCPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XpO2lEPTB;MD6zN|UzQSEQvF2= M2LFVnNCVkeHUh?=
IST-SL1 NVfLZZp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrhUohKSzVyPUCuN|U{PDNizszN Mly0V2FPT0WU
BE-13 NFy0XWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLFfFJOUUN3ME2wMlM3PDV7IN88US=> NX3L[YpzW0GQR1XS
COR-L88 NX:zVpdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwM{[1OEDPxE1? M3e0VnNCVkeHUh?=
DOHH-2 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwNEGwNlMh|ryP MV;TRW5ITVJ?
A704 NEL5N2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwNEK2O{DPxE1? NUTLcHd1W0GQR1XS
KNS-81-FD M1[5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NESz[WFKSzVyPUCuOFQxOTdizszN M2S5O3NCVkeHUh?=
RPMI-8226 NX\SPGNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P0[mlEPTB;MD60OVY2OiEQvF2= MkHsV2FPT0WU
TGBC24TKB NX;pfVVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P2VGlEPTB;MD60OVc4QCEQvF2= NFrxc|dUSU6JRWK=
NCI-H1304 NFS3N5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwNE[xOVch|ryP NF24RXNUSU6JRWK=
MOLT-13 NGrKNVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwNE[2NVMh|ryP MkHkV2FPT0WU
EW-22 MoS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DZcmlEPTB;MD60OlY4OSEQvF2= NGLQSYZUSU6JRWK=
MS-1 M4P6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwNE[5N|Mh|ryP MV3TRW5ITVJ?
RMG-I M2jH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUm4ZXBnUUN3ME2wMlQ6PDZ2IN88US=> NV2xWWhEW0GQR1XS
NTERA-S-cl-D1 NYjIcYxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3ETWM2OD1yLkWwNFE6KM7:TR?= NXLQZ41wW0GQR1XS
NCI-H1048 NFnqNndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\KXGlEPTB;MD61NFk2OyEQvF2= MWfTRW5ITVJ?
SW1417 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlr1TWM2OD1yLkW1OFM5KM7:TR?= NX\3SFI{W0GQR1XS
DB M1LXZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwNUewPEDPxE1? NUTR[HR4W0GQR1XS
MEG-01 NIfmOXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7z[|NKSzVyPUCuOVg{OiEQvF2= Mn;aV2FPT0WU
EW-13 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnSTWM2OD1yLkW4N|QyKM7:TR?= M{faTXNCVkeHUh?=
LAMA-84 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILkRo5KSzVyPUCuOVkzODdizszN NYHCN49JW0GQR1XS
J-RT3-T3-5 M3fJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DVRWlEPTB;MD62NFgxQCEQvF2= NIfuR4RUSU6JRWK=
MOLT-16 M2POVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:2SZhKSzVyPUCuOlUzPjRizszN NGrGfWtUSU6JRWK=
DU-4475 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm0TWM2OD1yLk[1OFI4KM7:TR?= M1TYOHNCVkeHUh?=
HAL-01 NUPHOXROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\ISGlEPTB;MD63NlU1QSEQvF2= M2q2bnNCVkeHUh?=
RD M2nVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwN{W4PVkh|ryP Mn\MV2FPT0WU
OAW-28 NHz6OIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3y5XWlEPTB;MD63PFM4KM7:TR?= Mn\IV2FPT0WU
HCC38 NFnRPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzWOHkzUUN3ME2wMlgxOTlizszN MUnTRW5ITVJ?
NMC-G1 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwOEGxNlEh|ryP M4rSR3NCVkeHUh?=
EW-16 MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LVSGlEPTB;MD64NVMzQCEQvF2= MYXTRW5ITVJ?
DU-145 NIX5PYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwOEm5NlMh|ryP NIjjZ2tUSU6JRWK=
HPAF-II NEPYOWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPLTWM2OD1yLkmyOlI5KM7:TR?= MkfxV2FPT0WU
A427 M{fVdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDMbHNKSzVyPUCuPVMxOjJizszN MX;TRW5ITVJ?
PA-1 M13De2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnVTWM2OD1yLkm1OlQzKM7:TR?= M3;ie3NCVkeHUh?=
OAW-42 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwOU[xOFYh|ryP NIPhdlZUSU6JRWK=
L-428 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXq0UZdGUUN3ME2xMlAyOjVizszN MWnTRW5ITVJ?
COLO-824 M4XFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwMEG3NFgh|ryP NFrYbJVUSU6JRWK=
P30-OHK NVP2WGo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HofmlEPTB;MT6wOFY5QCEQvF2= NFjIR4FUSU6JRWK=
NCI-H2170 M1rh[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFwME[yN{DPxE1? MWLTRW5ITVJ?
HCC2998 NYHRT4R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwMEexN|Uh|ryP NELUdGlUSU6JRWK=
NB14 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLSdG1KSzVyPUGuNVM4PDhizszN M4LYTHNCVkeHUh?=
TGBC1TKB MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPHd4xKSzVyPUGuNVQyPTJizszN M2j1V3NCVkeHUh?=
KP-N-YS MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rhU2lEPTB;MT6xOlI{PiEQvF2= NFjq[VVUSU6JRWK=
CAL-120 NHvxeo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:xbWlEPTB;MT6xOlQzQSEQvF2= NYnt[lZkW0GQR1XS
SBC-1 M1\UWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDOTWM2OD1zLkG5NFU{KM7:TR?= NWnPNo13W0GQR1XS
C32 Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;w[W9NUUN3ME2xMlE6ODh6IN88US=> MoTKV2FPT0WU
HCC2157 NYPzdGt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTpOZZLUUN3ME2xMlE6PDl2IN88US=> NGHzR4ZUSU6JRWK=
COLO-792 MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK4c2pVUUN3ME2xMlIxODdzIN88US=> NGjnbnBUSU6JRWK=
ES7 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3LTWM2OD1zLkK3PVUyKM7:TR?= M3X5cnNCVkeHUh?=
HEL NE\6OVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XJdWlEPTB;MT6zNVAzQSEQvF2= MnHWV2FPT0WU
ES4 NF7aO|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;sTWM2OD1zLkO0PVk5KM7:TR?= NXe1bGdNW0GQR1XS
NCI-SNU-1 NUHVeJhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFriSXhKSzVyPUGuN|Y2PTVizszN NUj0[2ZnW0GQR1XS
MDA-MB-415 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwM{i4OUDPxE1? M4Xjd3NCVkeHUh?=
NCI-H2342 NG\3[|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLybFhKSzVyPUGuOFAzPjlizszN NYPCbJRFW0GQR1XS
NB69 MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfkOVVwUUN3ME2xMlQ3OjdzIN88US=> M{L5bHNCVkeHUh?=
D-247MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL2TZQxUUN3ME2xMlUyOTJ{IN88US=> NWXpbZkzW0GQR1XS
SCC-4 M3TFOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L2WGlEPTB;MT61PVg5PyEQvF2= Moi4V2FPT0WU
HuH-7 NY\abm5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;KZ5BKSzVyPUGuOlczQTNizszN NHW0UGxUSU6JRWK=
A388 M4fKNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\BVJo4UUN3ME2xMlY5PzJ2IN88US=> NUKzbIR7W0GQR1XS
Calu-3 M3XmZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrLTWM2OD1zLkewOlk4KM7:TR?= M{jaNnNCVkeHUh?=
NCI-H1648 NUH0eldST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTFwN{G0NVgh|ryP M3TofXNCVkeHUh?=
NCI-H2052 MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFwN{KyNFEh|ryP NYX6VXhkW0GQR1XS
Ramos-2G6-4C10 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTFwN{O2OVYh|ryP M{PGfnNCVkeHUh?=
DEL MoXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PqbGlEPTB;MT63OFY6OiEQvF2= NVjLOVNNW0GQR1XS
SNU-423 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEWzSJVKSzVyPUGuO|gyPTdizszN NW\2bHg5W0GQR1XS
COR-L23 MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XWZWlEPTB;MT63PVg4PCEQvF2= M2XL[3NCVkeHUh?=
OMC-1 MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXOxdVRpUUN3ME2xMlg3ODF4IN88US=> MVHTRW5ITVJ?
EW-11 NYnxVo5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrYT2lKSzVyPUGuPVU3PTdizszN MVPTRW5ITVJ?
HSC-3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTFwOU[zOlUh|ryP M1\SRnNCVkeHUh?=
MLMA MnXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjMXohRUUN3ME2xMlk3Pjd5IN88US=> MmjjV2FPT0WU
RCM-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTJTWM2OD1{LkCwN|k6KM7:TR?= M2TNZXNCVkeHUh?=
MFE-280 NVy2XFBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\FVGxCUUN3ME2yMlAzQDR6IN88US=> MUjTRW5ITVJ?
ES8 NIDme5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4X6VWlEPTB;Mj6yOVQ4OSEQvF2= MUDTRW5ITVJ?
TE-11 NFnDeVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq1OlZKSzVyPUKuNlk1PzNizszN M33IV3NCVkeHUh?=
HuO-3N1 NF7NSGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH5VVhLUUN3ME2yMlQ5PzhizszN MVrTRW5ITVJ?
MHH-NB-11 MnHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{naR2lEPTB;Mj61NVE2QCEQvF2= NUPx[HB2W0GQR1XS
TGBC11TKB MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTRTWM2OD1{LkW3OlgyKM7:TR?= NV;XdJNjW0GQR1XS
HOP-92 NEfreWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon6TWM2OD1{LkW4O|Q{KM7:TR?= MXLTRW5ITVJ?
IGR-1 M2XnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXzPVlKSzVyPUKuOlIxOzVizszN NGW3coxUSU6JRWK=
GOTO MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJwNkWzO|ch|ryP NGKwO2VUSU6JRWK=
NCI-H1650 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3VXWNKSzVyPUKuO|IzOTVizszN M{XZdnNCVkeHUh?=
NCI-H1581 Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLJPXQ{UUN3ME2yMlc6PjhzIN88US=> M13lTnNCVkeHUh?=
NCI-H2405 M175bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPiRm46UUN3ME2yMlgzPzh{IN88US=> MXfTRW5ITVJ?
U-118-MG NYfuTnNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHtXopwUUN3ME2yMlk3PDlzIN88US=> M37aUHNCVkeHUh?=
DoTc2-4510 NHn3dG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnhdJNMUUN3ME2zMlAyPDF5IN88US=> MVzTRW5ITVJ?
NCI-H596 NFT5ZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7rSY5tUUN3ME2zMlA1QTl5IN88US=> M4H5PHNCVkeHUh?=
MPP-89 NVPOXnZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnKcGJ{UUN3ME2zMlA2PjZ4IN88US=> M1n6VnNCVkeHUh?=
GCIY Mk\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jwXmlEPTB;Mz6yNFQ6OSEQvF2= MXXTRW5ITVJ?
SW626 MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP3TXlOUUN3ME2zMlI1PTR|IN88US=> M2DN[nNCVkeHUh?=
OCI-AML2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTNwM{GyO|Ih|ryP MkPhV2FPT0WU
NBsusSR MmP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHqNJRWUUN3ME2zMlM1QTN6IN88US=> MnPvV2FPT0WU
AN3-CA NXuwfnc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzmRoNKSzVyPUOuOFQzOzhizszN Mo[2V2FPT0WU
EFM-19 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojUTWM2OD1|LkS4N|M6KM7:TR?= MlzFV2FPT0WU
RVH-421 NUXOOo5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3niZmlEPTB;Mz61Olg4PyEQvF2= MljoV2FPT0WU
5637 NE\teplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonPTWM2OD1|Lk[xNVA{KM7:TR?= NG\vXWJUSU6JRWK=
PANC-08-13 M1jNd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXxTGtKUUN3ME2zMlY{PDd{IN88US=> NEHKNoVUSU6JRWK=
H9 NYjkRXlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M36y[WlEPTB;Mz62O|E1PCEQvF2= M3[wcHNCVkeHUh?=
KARPAS-299 MkTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO4TWM2OD1|Lk[3N|YyKM7:TR?= MnzJV2FPT0WU
TE-5 MlzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e0XGlEPTB;Mz63NFcxQSEQvF2= Ml7YV2FPT0WU
NOS-1 M2HlXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTNwN{m4N|Qh|ryP NEmzeJdUSU6JRWK=
HH MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF32TINKSzVyPUOuPFM5PjhizszN Mnz3V2FPT0WU
769-P NXGwSVVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrjTWM2OD1|Lki5OVEh|ryP MmLlV2FPT0WU
CHP-212 M3XRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TpWmlEPTB;Mz65NlU1QSEQvF2= NFvCZ5dUSU6JRWK=
NCI-H82 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33FVGlEPTB;Mz65OVk{PiEQvF2= MnnvV2FPT0WU
Mo-T MnzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\TTWM2OD12LkC0N|EzKM7:TR?= MVzTRW5ITVJ?
BB65-RCC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvnUWxKSzVyPUSuNFQ{QTlizszN MXvTRW5ITVJ?
SW1990 NUK5eY8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHrTWM2OD12LkC1PVA5KM7:TR?= MU\TRW5ITVJ?
LK-2 NYqyWJZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jJbmlEPTB;ND6xNVI6OyEQvF2= MoOxV2FPT0WU
ES5 NYjmZnVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTBPIY{UUN3ME20MlE{QTh3IN88US=> NGrQbWxUSU6JRWK=
JVM-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf6U40xUUN3ME20MlE5OjJ{IN88US=> MXXTRW5ITVJ?
RPMI-7951 NW[2fmNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[ycmlEPTB;ND6yNlQyOyEQvF2= MUjTRW5ITVJ?
Calu-6 NH\QRnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIe5[m1KSzVyPUSuNlc5QDFizszN MkPCV2FPT0WU
LC-2-ad NWfYTnVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13CSGlEPTB;ND6yPVU3QCEQvF2= NEHzNGRUSU6JRWK=
SW954 M3TxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[2Z2lEPTB;ND6yPVY3KM7:TR?= NUTHc4JyW0GQR1XS
H-EMC-SS MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTRwM{G4N|Eh|ryP MVvTRW5ITVJ?
ES3 MkW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\5Tm5KSzVyPUSuN|U1PDFizszN NEH0PFFUSU6JRWK=
no-11 NUPNW21XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTRwM{W1OVQh|ryP MknMV2FPT0WU
LAN-6 NH25OFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S0OWlEPTB;ND60OVE5QSEQvF2= NXPTSoo5W0GQR1XS
FTC-133 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjRTWM2OD12LkWzPVUh|ryP Ml[wV2FPT0WU
8505C NGjnPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTRwNUSyN{DPxE1? NH3UVYRUSU6JRWK=
SW620 M173OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYC4NWFsUUN3ME20MlU4ODV5IN88US=> M1HhcHNCVkeHUh?=
BCPAP NWrFVVlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnndWdPUUN3ME20MlY{PDhzIN88US=> MV3TRW5ITVJ?
SK-LU-1 M1;ZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW2TWM2OD12Lk[2NFg6KM7:TR?= NXexR49jW0GQR1XS
NCI-H1623 MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTRwN{CyNlgh|ryP MmTVV2FPT0WU
C2BBe1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHzfI1yUUN3ME20Mlc1ODB6IN88US=> MX3TRW5ITVJ?
GP5d MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDje2hoUUN3ME20Mlc5Ozh6IN88US=> MmjuV2FPT0WU
NB6 NWn2bYhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3DTWM2OD12Lki2NlA1KM7:TR?= MWPTRW5ITVJ?
MDA-MB-157 NELifnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:5TWM2OD12Lki4O|Yh|ryP M3:1bnNCVkeHUh?=
UMC-11 MoTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTRwOEi5OlQh|ryP M1q1SnNCVkeHUh?=
HCC1419 NXOxeXlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTRwOUCwOlMh|ryP NIHpRo9USU6JRWK=
NCI-H2029 NHTnSINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFGxU2VKSzVyPUSuPVQyQDVizszN NVi0dnJvW0GQR1XS
LXF-289 M3TL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3W1c2lEPTB;NT6wN|cyQSEQvF2= Mkf0V2FPT0WU
KINGS-1 MnP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j5T2lEPTB;NT6wO|c1PCEQvF2= M4\zZnNCVkeHUh?=
HD-MY-Z NHrXe29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTVwMkO5Olkh|ryP NHHDcnFUSU6JRWK=
ESS-1 M4H2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vreGlEPTB;NT6yOVU6PyEQvF2= NVzFd25mW0GQR1XS
GI-1 MorxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnHTWM2OD13LkK3PVI3KM7:TR?= M4n4N3NCVkeHUh?=
RPMI-2650 Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnu0TWM2OD13LkO2NVYh|ryP MV3TRW5ITVJ?
IA-LM MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDoN2JwUUN3ME21MlM6QDdzIN88US=> NIPub2pUSU6JRWK=
KP-4 NFHzVHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rFTGlEPTB;NT60OlM{PCEQvF2= NVnZUZE{W0GQR1XS
G-402 M4PXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGeyPGpKSzVyPUWuOVE5PjVizszN NVTmfnJ5W0GQR1XS
OS-RC-2 NXLPNIFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUWw[VZ{UUN3ME21MlUzPjB2IN88US=> MUnTRW5ITVJ?
NCI-H1155 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HIO2lEPTB;NT61OFk2PSEQvF2= NU\jbFh3W0GQR1XS
OE19 MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjESY5KSzVyPUWuOlg3OjRizszN NGWzXIpUSU6JRWK=
U-2-OS MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jOR2lEPTB;NT64PVAyOyEQvF2= MmmzV2FPT0WU
SCC-15 NYG5SVBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnZNGpKSzVyPUWuPVM3PjJizszN NGiwc3ZUSU6JRWK=
NCI-H630 MnzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlriTWM2OD13Lkm5OFA1KM7:TR?= NEnY[JBUSU6JRWK=
PFSK-1 NYGyXJlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7VXoFCUUN3ME22MlA2OjV7IN88US=> MUTTRW5ITVJ?
NCI-H1770 M4j5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PQcWlEPTB;Nj6yNFg4PCEQvF2= MV3TRW5ITVJ?
SK-MEL-3 NFTjZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\PWZB[UUN3ME22MlQzQTF3IN88US=> MU\TRW5ITVJ?
LB1047-RCC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTZwNEe2NlUh|ryP NIq4T|hUSU6JRWK=
NCI-H446 MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTZwNkK5NlUh|ryP NVy3PG15W0GQR1XS
SW780 M2fiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTZwN{CxPFUh|ryP NHXseGVUSU6JRWK=
NEC8 NV3US4JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDGTWM2OD14Lke2OlMh|ryP NXXxeFY5W0GQR1XS
NOMO-1 NHvZOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnRe2xtUUN3ME22Mlc5OTFzIN88US=> NV;EOIZ1W0GQR1XS
COLO-668 NWjHeoNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTZwOESzPFch|ryP MoPPV2FPT0WU
MC116 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPBT2VKSzVyPU[uPVM5QTdizszN NXi1c4dLW0GQR1XS
HCC1937 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LCOWlEPTB;Nj65PVI2OSEQvF2= MmLvV2FPT0WU
NCI-N87 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X4VWlEPTB;Nz6xPVI6OyEQvF2= NW\CR2NHW0GQR1XS
COLO-320-HSR NGnDeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTdwMkK3N|gh|ryP NFTqVGFUSU6JRWK=
HCC1806 NGntSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTdwMk[wOFQh|ryP M2XyVHNCVkeHUh?=
OVCAR-3 NVnpWJB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnGNIZKSzVyPUeuN|MxOzhizszN NIPaRYpUSU6JRWK=
NUGC-3 M1vqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ezTmlEPTB;Nz6zPVY6PCEQvF2= M1znSnNCVkeHUh?=
SW1783 NHvzc2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTdwNEOxO|Uh|ryP NW\aR5E1W0GQR1XS
GCT M1rRc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTdwNU[5NFYh|ryP M{XUO3NCVkeHUh?=
NCI-H2126 NGHYVlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInHS4RKSzVyPUeuO|M3OjVizszN NHXWNGdUSU6JRWK=
MEL-HO MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z3NGlEPTB;Nz63O|A2PCEQvF2= M{fJXnNCVkeHUh?=
CAPAN-1 MnzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP0NFFnUUN3ME23Mlc4OzV5IN88US=> MWHTRW5ITVJ?
SW756 M1Ppb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljLTWM2OD15Lke4N|M{KM7:TR?= MnexV2FPT0WU
SKG-IIIa M{jmOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C4UWlEPTB;Nz64NVg6OiEQvF2= M1\PdXNCVkeHUh?=
HCE-T M2PmcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;ROGlEPTB;Nz64O|c5OyEQvF2= M1rSPHNCVkeHUh?=
Ca-Ski NXTHdYk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT6WmtuUUN3ME23Mlk6Ozh|IN88US=> NWnCcFR2W0GQR1XS
COLO-684 M1PSN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXkTWM2OD16LkCxPFE5KM7:TR?= NXHvXWRmW0GQR1XS
KYSE-70 NIW0e|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Tr[WlEPTB;OD6wO|czQSEQvF2= MUHTRW5ITVJ?
TI-73 MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXvW2ZKSzVyPUiuNlU5PTFizszN M{G2U3NCVkeHUh?=
BT-20 M3zXXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXJfmE2UUN3ME24MlI3ODV{IN88US=> MV\TRW5ITVJ?
MHH-ES-1 MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRThwNUG4N|Qh|ryP NHTQdpdUSU6JRWK=
TE-12 NHH0coxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPjOJR1UUN3ME24MlU6QTNzIN88US=> M4i5W3NCVkeHUh?=
YH-13 MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnkXYhKSzVyPUiuOlExODhizszN M2L2U3NCVkeHUh?=
SF126 NUPBd3E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRThwOEO4OlUh|ryP MYDTRW5ITVJ?
J82 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vKNWlEPTB;OD65NFA{QCEQvF2= MUHTRW5ITVJ?
RCC10RGB MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTMflAxUUN3ME24Mlk6PTZzIN88US=> MVHTRW5ITVJ?
SK-UT-1 MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrxTWM2OD17LkC0PVQ2KM7:TR?= MYPTRW5ITVJ?
LB2241-RCC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTlwMUmxN|ch|ryP NGrXR41USU6JRWK=
LB996-RCC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTlwMUm4PUDPxE1? MYrTRW5ITVJ?
EPLC-272H MlvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HTSmlEPTB;OT6zO|Y2PyEQvF2= NF7wZo9USU6JRWK=
CTV-1 NH3oOFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljzTWM2OD17LkW2OVMzKM7:TR?= MkPYV2FPT0WU
HSC-2 NFvRR|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\KO2NkUUN3ME25MlU4PTVizszN MXfTRW5ITVJ?
SK-MEL-28 NGjYO|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGCyUm9KSzVyPUmuOlE5QTNizszN NWfCW|JVW0GQR1XS
MMAC-SF MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DR[2lEPTB;OT62PFc2KM7:TR?= M2PpeHNCVkeHUh?=
CP50-MEL-B M3LMOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\STWM2OD17Lke1O|gzKM7:TR?= MXHTRW5ITVJ?
HT-1080 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTlwN{e3N|kh|ryP Ml:2V2FPT0WU
HEC-1 NHHVdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjQZmpKSzVyPUGwMlM{PTJizszN NGLDRoZUSU6JRWK=
AGS MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELLVHJKSzVyPUGwMlM4PCEQvF2= NIPheVZUSU6JRWK=
GAMG M1;qSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFyLkWxOlIh|ryP MXzTRW5ITVJ?
SW48 NFrlW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFyLkWxPFkh|ryP MV7TRW5ITVJ?
U031 NYT0S5c2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTFyLkW5NFgh|ryP M{W3TnNCVkeHUh?=
OVCAR-5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjBZ2RKSzVyPUGwMlY1OjlizszN MmLMV2FPT0WU
SF295 MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFyLk[3NFQh|ryP NFvXfoZUSU6JRWK=
BHT-101 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTFyLkexO|ch|ryP NXXGRlRiW0GQR1XS
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DSH1 NFXU[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTR3LkCwN|Mh|ryP MYDTRW5ITVJ?
MCF7 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTR3LkWwOVEh|ryP M3TXZ3NCVkeHUh?=
K5 NH\JWZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnhWVhzUUN3ME20OU46PDB3IN88US=> MW\TRW5ITVJ?
NCI-H358 Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFziR4ZKSzVyPUS3MlIyPSEQvF2= MWrTRW5ITVJ?
NCI-H2030 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTR5LkKzO|Qh|ryP M4HUR3NCVkeHUh?=
SW948 NWPBbmxXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTR5LkS2OEDPxE1? MoriV2FPT0WU
BALL-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHYPHg3UUN3ME20O{43OTZ6IN88US=> M4mxbnNCVkeHUh?=
TE-9 M3r0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR5Lkm1PFEh|ryP MlXhV2FPT0WU
SK-N-FI MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTR6LkCzOVgh|ryP MmfIV2FPT0WU
KALS-1 NIrmU25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:0e2ZKSzVyPUS4MlEzQDlizszN NFTmPZRUSU6JRWK=
HO-1-N-1 NVfvWVJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTR6Lke0OFUh|ryP NFvScllUSU6JRWK=
NCI-H2452 M{HlfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\ETWM2OD12OT6xNVUzKM7:TR?= NHjIXWpUSU6JRWK=
OC-314 MlTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTR7Lk[4N|Qh|ryP NYjN[lZiW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 When ABT-263 is administered at 100 mg/kg/day in the H345 xenograft model, significant antitumor efficacy is observed with 80% TGI and 20% of treated tumors indicating at least a 50% reduction in tumor volume. [2] Oral administration of ABT-263 alone causes complete tumor regressions in xenograft models of small-cell lung cancer and acute lymphoblastic leukemia. In xenograft models of aggressive B-cell lymphoma and multiple myeloma where ABT-263 displays modest or no single agent activity, it significantly enhances the efficacy of clinically relevant therapeutic regimens. [2]
臨床試験 ABT-263 is currently in Phase II clinical trial for the treatments of chronic lymphocytic leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Affinity determination Binding affinities (Ki or IC50) of ABT-263 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and Bcl-2 (10 nM), f-Bax (1 nM) and Bcl-w (40 nM), f-Noxa (2 nM) and Mcl-1 (40 nM), and f-Bax (1 nM) and Bcl-2-A1 (15 nM). Binding affinities for Bcl-xL are also determined using a time-resolved fluorescence resonance energy transfer assay. Bcl-xL (1 nM, His tagged) is mixed with 200 nM f-Bak, 1 nM Tb-labeled anti-His antibody, and ABT-263 at room temperature for 30 min. Fluorescence is measured on an Envision plate reader using a 340/35 nm excitation filter and 520/525 (f-Bak) and 495/510 nm (Tb-labeled anti-His antibody) emission filters.

細胞アッセイ:

[1]

細胞株 SCLC cell lines
濃度 0-1 μM
反応時間 48 hours
実験の流れ

Human tumor cell lines SCLC cell lines are maintained at 37 °C containing 5% CO2. SCLC cell lines are cultured in RPMI 1640 with 10% fetal bovine serum (FBS), 1% sodium pyruvate, 25 mM HEPES, 4.5 g/L glucose, and 1% penicillin/streptomycin. Leukemia and lymphoma cell lines are cultured in RPMI 1640 supplemented with 10% FBS and 1% penicillin/streptomycin. Cells (1-5×10 4) are treated by ABT-263 for 48 hours in 96-well culture plates in a final volume of 100 μL and cytotoxicity is assessed with the CellTiter Glo assay. In vitro cyto toxicity of ABT-263 is assayed.

動物実験:

[1]

動物モデル C.B.-17 scid-bg or C.B.-17 scid mice
製剤 Formulated in 10% ethanol, 30% polyethylene glycol 400, and 60% Phosal 50 PG
投薬量 100 mg/kg/d
投与方法 Administered via p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download ABT-263 (Navitoclax) SDF
分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS No. 923564-51-6
保管 2年-20℃
6月-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 100 mg/mL (102.6 mM)
<1 mg/mL (<1 mM)
エタノール <1 mg/mL (<1 mM)
In vivo 5% DMSO+corn oil 7mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4-​[4-​[[2-​(4-​chlorophenyl)​-​5,​5-​dimethyl-​1-​cyclohexen-​1-​yl]​methyl]​-​1-​piperazinyl]​-​N-​[[4-​[[(1R)​-​3-​(4-​morpholinyl)​-​1-​[(phenylthio)​methyl]​propyl]​amino]​-​3-​[(trifluoromethyl)​sulfonyl]​phenyl]​sulfonyl]​-benzamide

文献中の引用 (36)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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