ABT-263 (Navitoclax)

ABT-263 (Navitoclax)は一種の有効なBcl-xL、Bcl-2とBcl-w阻害剤で、無細胞試験でKi値が0.5 nM及び0.5 nM以下、1nM及び1nM以下と1nM及び1nM以下にそれぞれ分かれることですが、Mcl-1、A1と結合する作用が少し弱いです。臨床2期。

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ABT-263 (Navitoclax) 化学構造
分子量: 974.61

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製品説明

  • Compare Bcl-2 Inhibitors
    Bcl-2製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 ABT-263 (Navitoclax)は一種の有効なBcl-xL、Bcl-2とBcl-w阻害剤で、無細胞試験でKi値が0.5 nM及び0.5 nM以下、1nM及び1nM以下と1nM及び1nM以下にそれぞれ分かれることですが、Mcl-1、A1と結合する作用が少し弱いです。臨床2期。
ターゲット

Bcl-xL

Bcl-2

Bcl-w

IC50

≤ 0.5 nM (Ki)

≤1 nM (Ki)

≤ 1 nM (Ki)[1]

In vitro試験 ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. [1] A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGw[|NKSzVyPUCuNFA3PjlizszN NHzEbmFUSU6JRWK=
MV-4-11 M4L4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j2c2lEPTB;MD6wNVU5PiEQvF2= M1zrd3NCVkeHUh?=
NKM-1 NXzOcWpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnmSVhKSzVyPUCuNFE3QTlizszN NHn6OnZUSU6JRWK=
ML-2 NGDvPGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEG5PFMh|ryP NF20[mVUSU6JRWK=
BV-173 NEHDdY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K5WWlEPTB;MD6wNlMyPCEQvF2= M1TBcnNCVkeHUh?=
RS4-11 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDwTWM2OD1yLkCyOVg4KM7:TR?= MUXTRW5ITVJ?
HL-60 NXvje|JpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEK5NFgh|ryP M1f0V3NCVkeHUh?=
KY821 NH7NOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1eyTGlEPTB;MD6wNlk4PSEQvF2= MXzTRW5ITVJ?
ECC10 M330eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTCNYEyUUN3ME2wMlA{Pzl{IN88US=> MlXsV2FPT0WU
NCI-H720 M4jFNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMESwNVEh|ryP NUDVd3dbW0GQR1XS
QIMR-WIL Mkj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjKXGFKSzVyPUCuNFQzQDdizszN NWXt[HdTW0GQR1XS
KG-1 MnXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TZdWlEPTB;MD6wOFQ5PiEQvF2= NHKwclNUSU6JRWK=
TGW MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMES2N|Mh|ryP MljoV2FPT0WU
ATN-1 NEPTd5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj3WIJKSzVyPUCuNFQ4OzNizszN M{\wZnNCVkeHUh?=
RH-18 NEDUdFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[2b3g5UUN3ME2wMlA3ODR6IN88US=> NX7XPGxIW0GQR1XS
EW-18 MnT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\Wc|RKSzVyPUCuNFY5PDFizszN MVzTRW5ITVJ?
NB17 M2H3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEexNlQh|ryP NXrxZZAxW0GQR1XS
SK-NEP-1 NXvmdmRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{ntemlEPTB;MD6wO|IyOyEQvF2= NVG5Rm5CW0GQR1XS
P12-ICHIKAWA MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHHSIhKSzVyPUCuNFc4PzhizszN MULTRW5ITVJ?
KARPAS-45 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f3bGlEPTB;MD6wO|gyPSEQvF2= NWf6e45OW0GQR1XS
EW-3 Mn\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq0TWM2OD1yLkC4NFU{KM7:TR?= MYHTRW5ITVJ?
NB13 Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXmXWtXUUN3ME2wMlA5OjB|IN88US=> M2rTcnNCVkeHUh?=
NCI-H209 NVv3NVRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnMWZJKSzVyPUCuNFg4ODRizszN MljzV2FPT0WU
NCI-H1092 Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnWTWM2OD1yLkGwNlc2KM7:TR?= M{W2S3NCVkeHUh?=
NH-12 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzPSlZHUUN3ME2wMlExPzR2IN88US=> MYjTRW5ITVJ?
697 M3vTNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonGTWM2OD1yLkGwPFM6KM7:TR?= NYi0PVZ2W0GQR1XS
KE-37 NEjadXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jnUmlEPTB;MD6xNVM4KM7:TR?= M{DXTnNCVkeHUh?=
MOLT-4 MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn3TWM2OD1yLkG1NVY6KM7:TR?= MoPoV2FPT0WU
CHP-134 NVe1RmhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3KxT2lEPTB;MD6xOlMxPiEQvF2= MmjqV2FPT0WU
D-283MED NIH3emlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHftWINKSzVyPUCuNVc3QDZizszN MoTTV2FPT0WU
LU-135 NUPlZW1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrpTWM2OD1yLkG4OVUzKM7:TR?= Mmi5V2FPT0WU
LU-134-A MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\wO2lEPTB;MD6xPFY4OSEQvF2= NVLWe|BzW0GQR1XS
EM-2 M4DnTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMUm5NVgh|ryP NWP0WGdUW0GQR1XS
LU-139 Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXqzbVFRUUN3ME2wMlIxPDl6IN88US=> MlHCV2FPT0WU
ALL-PO NVjt[XpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LPSmlEPTB;MD6yNVk5QCEQvF2= NGq5bVJUSU6JRWK=
NB12 MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrtVG1KSzVyPUCuNlMyOTVizszN NYCwW244W0GQR1XS
KP-N-YN Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTRVHdKSzVyPUCuNlM2PzNizszN MnPUV2FPT0WU
BEN MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXVVodMUUN3ME2wMlI{QTZ6IN88US=> MWLTRW5ITVJ?
HCC1569 NEL1U5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDiWVFKSzVyPUCuNlUyODZizszN MUXTRW5ITVJ?
HuO9 NHLST3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMk[3NVUh|ryP NWjUbGVuW0GQR1XS
WM-115 MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XzZWlEPTB;MD6yO|c{QCEQvF2= MU\TRW5ITVJ?
CCRF-CEM NIjIT4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwM{O1Nlkh|ryP NXKyfng{W0GQR1XS
IST-SL1 MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:2WJZiUUN3ME2wMlM2OzR|IN88US=> NIn3S3RUSU6JRWK=
BE-13 NH;sVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PHU2lEPTB;MD6zOlQ2QSEQvF2= MojJV2FPT0WU
COR-L88 Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwM{[1OEDPxE1? NUexXnhUW0GQR1XS
DOHH-2 M4rwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS5cZdKSzVyPUCuOFExOjNizszN MnPMV2FPT0WU
A704 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7qRmFKSzVyPUCuOFI3PyEQvF2= M4nKU3NCVkeHUh?=
KNS-81-FD NFPEdodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXITWM2OD1yLkS0NFE4KM7:TR?= NUnCWZFVW0GQR1XS
RPMI-8226 M2OwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwNEW2OVIh|ryP M2PXdHNCVkeHUh?=
TGBC24TKB NXfvTXU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf3TolKSzVyPUCuOFU4PzhizszN NEjrUYFUSU6JRWK=
NCI-H1304 NXzjPHRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HTOmlEPTB;MD60OlE2PyEQvF2= M3HLdHNCVkeHUh?=
MOLT-13 NXexO2tJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwNE[2NVMh|ryP M3LwXXNCVkeHUh?=
EW-22 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwNE[2O|Eh|ryP NUHRdJBVW0GQR1XS
MS-1 NW\LWGQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWriSHZGUUN3ME2wMlQ3QTN|IN88US=> NVvTWpFbW0GQR1XS
RMG-I Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHaSItKSzVyPUCuOFk1PjRizszN NGTqTo5USU6JRWK=
NTERA-S-cl-D1 M33sbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwNUCwNVkh|ryP Mm\SV2FPT0WU
NCI-H1048 NXHJSm1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2GwRWlEPTB;MD61NFk2OyEQvF2= M1jrcXNCVkeHUh?=
SW1417 M4i5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX4[GdxUUN3ME2wMlU2PDN6IN88US=> M13ZTHNCVkeHUh?=
DB NXHxNZFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2KwemlEPTB;MD61O|A5KM7:TR?= M1zqVnNCVkeHUh?=
MEG-01 MkHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXDTWM2OD1yLkW4N|Ih|ryP NV;DRVFoW0GQR1XS
EW-13 NEf1PHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T1bmlEPTB;MD61PFM1OSEQvF2= MnjXV2FPT0WU
LAMA-84 NEfRNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwNUmyNFch|ryP NHvaN|VUSU6JRWK=
J-RT3-T3-5 M2ixSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnUN2FKSzVyPUCuOlA5ODhizszN MWnTRW5ITVJ?
MOLT-16 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHL0VXRKSzVyPUCuOlUzPjRizszN NIPCT5hUSU6JRWK=
DU-4475 NVrKbnNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwNkW0Nlch|ryP MXzTRW5ITVJ?
HAL-01 NGXwOGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojuTWM2OD1yLkeyOVQ6KM7:TR?= M2LxO3NCVkeHUh?=
RD MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7VSG1mUUN3ME2wMlc2QDl7IN88US=> MXvTRW5ITVJ?
OAW-28 MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\wTWM2OD1yLke4N|ch|ryP MoTaV2FPT0WU
HCC38 NUTIPGV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3u0VGlEPTB;MD64NFE6KM7:TR?= NHnBfZpUSU6JRWK=
NMC-G1 M3m1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnD[FVJUUN3ME2wMlgyOTJzIN88US=> M4ewb3NCVkeHUh?=
EW-16 NUHIOG01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\abGlEPTB;MD64NVMzQCEQvF2= MYrTRW5ITVJ?
DU-145 MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHjTWM2OD1yLki5PVI{KM7:TR?= MojmV2FPT0WU
HPAF-II MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP6WVk3UUN3ME2wMlkzPjJ6IN88US=> NInK[XdUSU6JRWK=
A427 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{CwOWlEPTB;MD65N|AzOiEQvF2= NVL5OZpMW0GQR1XS
PA-1 NF\aO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1eyOmlEPTB;MD65OVY1OiEQvF2= MWrTRW5ITVJ?
OAW-42 Ml3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwOU[xOFYh|ryP NYfRS4ZnW0GQR1XS
L-428 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\jTWM2OD1zLkCxNlUh|ryP M{XWSnNCVkeHUh?=
COLO-824 MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13LS2lEPTB;MT6wNVcxQCEQvF2= NIXISo1USU6JRWK=
P30-OHK M3fKdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2KwbGlEPTB;MT6wOFY5QCEQvF2= MmnNV2FPT0WU
NCI-H2170 M1H0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;sTWM2OD1zLkC2NlMh|ryP MmntV2FPT0WU
HCC2998 NF7n[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESyZ|ZKSzVyPUGuNFcyOzVizszN MWTTRW5ITVJ?
NB14 NG\iWo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTFwMUO3OFgh|ryP MkDwV2FPT0WU
TGBC1TKB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTzcVh1UUN3ME2xMlE1OTV{IN88US=> MnK0V2FPT0WU
KP-N-YS MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXxVHhoUUN3ME2xMlE3OjN4IN88US=> NXfDfGxxW0GQR1XS
CAL-120 M2nzbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwMU[0Nlkh|ryP M{CzbXNCVkeHUh?=
SBC-1 NW\ETIpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:2NmhYUUN3ME2xMlE6ODV|IN88US=> NETPVIpUSU6JRWK=
C32 NXjQeHFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFwMUmwPFgh|ryP M2DoXnNCVkeHUh?=
HCC2157 M1LiSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmqwTWM2OD1zLkG5OFk1KM7:TR?= M2HDXHNCVkeHUh?=
COLO-792 M3PqS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPW[XZZUUN3ME2xMlIxODdzIN88US=> NUHFWI5sW0GQR1XS
ES7 M{TpfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHOXoJKSzVyPUGuNlc6PTFizszN NWDrcotJW0GQR1XS
HEL MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoKyTWM2OD1zLkOxNFI6KM7:TR?= MYjTRW5ITVJ?
ES4 M2faVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTQTWM2OD1zLkO0PVk5KM7:TR?= NGDxemxUSU6JRWK=
NCI-SNU-1 NX\EOHEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTFwM{[1OVUh|ryP Mn;4V2FPT0WU
MDA-MB-415 NED3PJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVmwW5U1UUN3ME2xMlM5QDVizszN NWm1d3FIW0GQR1XS
NCI-H2342 MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETIZXNKSzVyPUGuOFAzPjlizszN M2\LdXNCVkeHUh?=
NB69 NGXrdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrXN2lKSzVyPUGuOFYzPzFizszN MUjTRW5ITVJ?
D-247MG NEW2TG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW3TWM2OD1zLkWxNVIzKM7:TR?= NVf0[|dZW0GQR1XS
SCC-4 NU\uSIJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\KV|VKSzVyPUGuOVk5QDdizszN NWO2U4t{W0GQR1XS
HuH-7 NVi5bpUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP6TWM2OD1zLk[3Nlk{KM7:TR?= MlnBV2FPT0WU
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Calu-3 M{XaO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrzbFhKSzVyPUGuO|A3QTdizszN NVfmdHp3W0GQR1XS
NCI-H1648 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXuzOpNZUUN3ME2xMlcyPDF6IN88US=> MYPTRW5ITVJ?
NCI-H2052 Mmj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;CTWM2OD1zLkeyNlAyKM7:TR?= MUHTRW5ITVJ?
Ramos-2G6-4C10 M3zsPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvEbJhRUUN3ME2xMlc{PjV4IN88US=> NEfWUoVUSU6JRWK=
DEL MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlKyTWM2OD1zLke0OlkzKM7:TR?= NFjBenVUSU6JRWK=
SNU-423 NFv1epNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS1TWM2OD1zLke4NVU4KM7:TR?= M1nIfHNCVkeHUh?=
COR-L23 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPMTWM2OD1zLke5PFc1KM7:TR?= MVHTRW5ITVJ?
OMC-1 MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHDdotKSzVyPUGuPFYxOTZizszN NWXHbZR{W0GQR1XS
EW-11 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXPXYJHUUN3ME2xMlk2PjV5IN88US=> MX7TRW5ITVJ?
HSC-3 NFLTZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTaeoFKSzVyPUGuPVY{PjVizszN NIGzdZNUSU6JRWK=
MLMA MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3qWIRKSzVyPUGuPVY3PzdizszN NFXCc5BUSU6JRWK=
RCM-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvCTVZKSzVyPUKuNFA{QTlizszN M3;5THNCVkeHUh?=
MFE-280 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LDdmlEPTB;Mj6wNlg1QCEQvF2= MkDmV2FPT0WU
ES8 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDEflFKSzVyPUKuNlU1PzFizszN MljzV2FPT0WU
TE-11 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJwMkm0O|Mh|ryP NFHyVJNUSU6JRWK=
HuO-3N1 M17LUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL5N|FKSzVyPUKuOFg4QCEQvF2= NEnnVpdUSU6JRWK=
MHH-NB-11 MnWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nSTmlEPTB;Mj61NVE2QCEQvF2= NXvYPZNLW0GQR1XS
TGBC11TKB MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULSUHRvUUN3ME2yMlU4PjhzIN88US=> MX7TRW5ITVJ?
HOP-92 NUHsd41{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXjZVVKSzVyPUKuOVg4PDNizszN MknLV2FPT0WU
IGR-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn6XZdKSzVyPUKuOlIxOzVizszN M4fpN3NCVkeHUh?=
GOTO NVPzWFFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TGbWlEPTB;Mj62OVM4PyEQvF2= MVXTRW5ITVJ?
NCI-H1650 NIjJbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJwN{KyNVUh|ryP MV\TRW5ITVJ?
NCI-H1581 NF;oSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy5d|JKSzVyPUKuO|k3QDFizszN NFXwT2tUSU6JRWK=
NCI-H2405 NHLae2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwOEK3PFIh|ryP MWPTRW5ITVJ?
U-118-MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli5TWM2OD1{Lkm2OFkyKM7:TR?= M3\T[XNCVkeHUh?=
DoTc2-4510 M1q2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nlNGlEPTB;Mz6wNVQyPyEQvF2= NHfvPJNUSU6JRWK=
NCI-H596 M4XmZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTNwMES5PVch|ryP NU\4TphMW0GQR1XS
MPP-89 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofYTWM2OD1|LkC1OlY3KM7:TR?= NWXIRWR5W0GQR1XS
GCIY MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33TVGlEPTB;Mz6yNFQ6OSEQvF2= MkjvV2FPT0WU
SW626 MmTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP3TWM2OD1|LkK0OVQ{KM7:TR?= MmPuV2FPT0WU
OCI-AML2 NHHnWYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTNwM{GyO|Ih|ryP MnjHV2FPT0WU
NBsusSR NYGxXFNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;LTWM2OD1|LkO0PVM5KM7:TR?= MlrtV2FPT0WU
AN3-CA NFzKephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi3WYFXUUN3ME2zMlQ1OjN6IN88US=> NV\uXFNrW0GQR1XS
EFM-19 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnSS25KSzVyPUOuOFg{OzlizszN M3:4dXNCVkeHUh?=
RVH-421 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HL[2lEPTB;Mz61Olg4PyEQvF2= Mn2wV2FPT0WU
5637 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTNwNkGxNFMh|ryP MoLHV2FPT0WU
PANC-08-13 NYT2[Ys3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXK2Z|VKUUN3ME2zMlY{PDd{IN88US=> NEDmZnhUSU6JRWK=
H9 NEi2dVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[2[2lEPTB;Mz62O|E1PCEQvF2= NVLaU|FNW0GQR1XS
KARPAS-299 NHLmdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3UW45KSzVyPUOuOlc{PjFizszN M3OzW3NCVkeHUh?=
TE-5 MlH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDYc|E1UUN3ME2zMlcxPzB7IN88US=> M2XGc3NCVkeHUh?=
NOS-1 NHXBdJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWWyTGRTUUN3ME2zMlc6QDN2IN88US=> M3vvOHNCVkeHUh?=
HH NWXNPFFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLFTplqUUN3ME2zMlg{QDZ6IN88US=> M{XkNnNCVkeHUh?=
769-P NXrzT|V2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTNwOEm1NUDPxE1? MoPaV2FPT0WU
CHP-212 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zVbmlEPTB;Mz65NlU1QSEQvF2= MXnTRW5ITVJ?
NCI-H82 NIPHZZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTNwOUW5N|Yh|ryP NIDte41USU6JRWK=
Mo-T MnuwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi1TWM2OD12LkC0N|EzKM7:TR?= NHXP[4tUSU6JRWK=
BB65-RCC NIr2[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTRwMESzPVkh|ryP NYnqc2ptW0GQR1XS
SW1990 NYHoZVJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYOzUWk4UUN3ME20MlA2QTB6IN88US=> NVvuR2xEW0GQR1XS
LK-2 MkfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPGTWM2OD12LkGxNlk{KM7:TR?= NX7NZWVZW0GQR1XS
ES5 M2[1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv0TWM2OD12LkGzPVg2KM7:TR?= NHG3VWJUSU6JRWK=
JVM-3 M2jIWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnUTWM2OD12LkG4NlIzKM7:TR?= M{PJcHNCVkeHUh?=
RPMI-7951 NXXkUpR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP4TWM2OD12LkKyOFE{KM7:TR?= MnnzV2FPT0WU
Calu-6 NGiwU4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTRwMke4PFEh|ryP MV\TRW5ITVJ?
LC-2-ad M2fiemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITLZnlKSzVyPUSuNlk2PjhizszN M3fvb3NCVkeHUh?=
SW954 M3XjTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYC3cpZXUUN3ME20MlI6PjZizszN M2iy[nNCVkeHUh?=
H-EMC-SS M4jBc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrzTWM2OD12LkOxPFMyKM7:TR?= MU\TRW5ITVJ?
ES3 M33mZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq5b5lIUUN3ME20MlM2PDRzIN88US=> NV\wW2hyW0GQR1XS
no-11 NF7ybWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXxd2ZKSzVyPUSuN|U2PTRizszN NED5TYhUSU6JRWK=
LAN-6 MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TjemlEPTB;ND60OVE5QSEQvF2= MknGV2FPT0WU
FTC-133 NXjFcmlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\tN3BKSzVyPUSuOVM6PSEQvF2= MX3TRW5ITVJ?
8505C Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTRwNUSyN{DPxE1? MkSxV2FPT0WU
SW620 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPYTHdKSzVyPUSuOVcxPTdizszN MYfTRW5ITVJ?
BCPAP MnrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYKzT4syUUN3ME20MlY{PDhzIN88US=> NF;QfXNUSU6JRWK=
SK-LU-1 M3Tpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XtVWlEPTB;ND62OlA5QSEQvF2= MXrTRW5ITVJ?
NCI-H1623 Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfpR|lKSzVyPUSuO|AzOjhizszN MUfTRW5ITVJ?
C2BBe1 M3r4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7EcWNxUUN3ME20Mlc1ODB6IN88US=> M2fDe3NCVkeHUh?=
GP5d MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTRwN{izPFgh|ryP M1r0SnNCVkeHUh?=
NB6 MojjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofsTWM2OD12Lki2NlA1KM7:TR?= M1jucnNCVkeHUh?=
MDA-MB-157 NEDGV|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnMTWM2OD12Lki4O|Yh|ryP NWLlNYdLW0GQR1XS
UMC-11 NVjKfYE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HMNWlEPTB;ND64PFk3PCEQvF2= MYHTRW5ITVJ?
HCC1419 NWnCcZlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PyOmlEPTB;ND65NFA3OyEQvF2= NXHtWYgzW0GQR1XS
NCI-H2029 M{nLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHjTWM2OD12Lkm0NVg2KM7:TR?= NInjNndUSU6JRWK=
LXF-289 NWLaUldbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTVwMEO3NVkh|ryP NFjOVIFUSU6JRWK=
KINGS-1 MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTVwMEe3OFQh|ryP MknsV2FPT0WU
HD-MY-Z NY\kXotqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS4TWM2OD13LkKzPVY6KM7:TR?= NUTZXXYxW0GQR1XS
ESS-1 NX7WbmFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\xUmlEPTB;NT6yOVU6PyEQvF2= NYq5TZFLW0GQR1XS
GI-1 MkP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTlTWM2OD13LkK3PVI3KM7:TR?= NID6TnBUSU6JRWK=
RPMI-2650 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS0TWM2OD13LkO2NVYh|ryP MlO2V2FPT0WU
IA-LM MmG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3JRmpZUUN3ME21MlM6QDdzIN88US=> NHPURnpUSU6JRWK=
KP-4 M1rBc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjid4dVUUN3ME21MlQ3OzN2IN88US=> NE\jbWtUSU6JRWK=
G-402 NUTOOYZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP2TWM2OD13LkWxPFY2KM7:TR?= MUnTRW5ITVJ?
OS-RC-2 NFvr[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvrTWM2OD13LkWyOlA1KM7:TR?= M37TfHNCVkeHUh?=
NCI-H1155 M1vEXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r2UWlEPTB;NT61OFk2PSEQvF2= MWDTRW5ITVJ?
OE19 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTVwNki2NlQh|ryP NGfseo5USU6JRWK=
U-2-OS NGOxU|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XaOGlEPTB;NT64PVAyOyEQvF2= MoH4V2FPT0WU
SCC-15 NYHqPFZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu4R3drUUN3ME21Mlk{PjZ{IN88US=> MYXTRW5ITVJ?
NCI-H630 NYOzZ4RiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFKxbYRKSzVyPUWuPVk1ODRizszN NIqxUW5USU6JRWK=
PFSK-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTZwMEWyOVkh|ryP NVOwPFZ5W0GQR1XS
NCI-H1770 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TmdmlEPTB;Nj6yNFg4PCEQvF2= NYL2SYpiW0GQR1XS
SK-MEL-3 NGDUd21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLFdGpKSzVyPU[uOFI6OTVizszN M1izNHNCVkeHUh?=
LB1047-RCC MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTZwNEe2NlUh|ryP NWL2UWhkW0GQR1XS
NCI-H446 M3nJRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD5PHJiUUN3ME22MlYzQTJ3IN88US=> NHi0RWZUSU6JRWK=
SW780 NGKzdZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzhbnl5UUN3ME22MlcxOTh3IN88US=> M2LOT3NCVkeHUh?=
NEC8 M3fkcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTZwN{[2N{DPxE1? MWrTRW5ITVJ?
NOMO-1 NWS5WpFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEeyZYhKSzVyPU[uO|gyOTFizszN MlzOV2FPT0WU
COLO-668 NHu3TJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[x[45XUUN3ME22Mlg1Ozh5IN88US=> MkGxV2FPT0WU
MC116 NYi1NHBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[1PXpDUUN3ME22Mlk{QDl5IN88US=> MUfTRW5ITVJ?
HCC1937 M3Tqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLJZlFZUUN3ME22Mlk6OjVzIN88US=> M2W4NHNCVkeHUh?=
NCI-N87 NUjIcHhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e2WmlEPTB;Nz6xPVI6OyEQvF2= NVXvUGp[W0GQR1XS
COLO-320-HSR MoS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPubIlyUUN3ME23MlIzPzN6IN88US=> M2G4fHNCVkeHUh?=
HCC1806 M3PqXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfSepJmUUN3ME23MlI3ODR2IN88US=> MWHTRW5ITVJ?
OVCAR-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TmdGlEPTB;Nz6zN|A{QCEQvF2= MlnTV2FPT0WU
NUGC-3 NYHlW4ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrYVIxHUUN3ME23MlM6Pjl2IN88US=> MUfTRW5ITVJ?
SW1783 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPWUoF7UUN3ME23MlQ{OTd3IN88US=> M1LxOHNCVkeHUh?=
GCT Ml\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;rOXQ4UUN3ME23MlU3QTB4IN88US=> MUTTRW5ITVJ?
NCI-H2126 MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\sNWlEPTB;Nz63N|YzPSEQvF2= Mn60V2FPT0WU
MEL-HO NFHoPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTdwN{ewOVQh|ryP MoTvV2FPT0WU
CAPAN-1 NFz1d5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTdwN{ezOVch|ryP NYrJbINMW0GQR1XS
SW756 Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH3RnpIUUN3ME23Mlc5OzN|IN88US=> Ml;BV2FPT0WU
SKG-IIIa M3nzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn4TWM2OD15LkixPFkzKM7:TR?= MYPTRW5ITVJ?
HCE-T M1HRRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3OxOGlEPTB;Nz64O|c5OyEQvF2= NE[wUVVUSU6JRWK=
Ca-Ski M4T6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjmVGdKSzVyPUeuPVk{QDNizszN MWfTRW5ITVJ?
COLO-684 NGfC[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjZUXFKSzVyPUiuNFE5OThizszN M{f3fHNCVkeHUh?=
KYSE-70 NHTydWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULsdlh7UUN3ME24MlA4PzJ7IN88US=> MX3TRW5ITVJ?
TI-73 NYrXNVFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1e0NmlEPTB;OD6yOVg2OSEQvF2= MYDTRW5ITVJ?
BT-20 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;WeVBKSzVyPUiuNlYxPTJizszN MWjTRW5ITVJ?
MHH-ES-1 NEjlcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRThwNUG4N|Qh|ryP MXfTRW5ITVJ?
TE-12 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGf4U29KSzVyPUiuOVk6OzFizszN Moq4V2FPT0WU
YH-13 M2HiW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHLNIpKSzVyPUiuOlExODhizszN MmnaV2FPT0WU
SF126 NVSzTnZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1ry[2lEPTB;OD64N|g3PSEQvF2= NXG4ZoNyW0GQR1XS
J82 M1LVSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzpTWM2OD16LkmwNFM5KM7:TR?= NYPzbYMzW0GQR1XS
RCC10RGB NIDkNWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS1RVFKSzVyPUiuPVk2PjFizszN M1vvcXNCVkeHUh?=
SK-UT-1 NIL0bGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzPTWM2OD17LkC0PVQ2KM7:TR?= NGDSN4JUSU6JRWK=
LB2241-RCC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTlwMUmxN|ch|ryP NHvGb21USU6JRWK=
LB996-RCC NVTDdXVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTlwMUm4PUDPxE1? NUHVWnRzW0GQR1XS
EPLC-272H MlTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkX4TWM2OD17LkO3OlU4KM7:TR?= MoqzV2FPT0WU
CTV-1 M2q0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlz1TWM2OD17LkW2OVMzKM7:TR?= MV;TRW5ITVJ?
HSC-2 M2O0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfqTWM2OD17LkW3OVUh|ryP MkTCV2FPT0WU
SK-MEL-28 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\YPW9EUUN3ME25MlYyQDl|IN88US=> MU\TRW5ITVJ?
MMAC-SF NVzyfWNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTlwNki3OUDPxE1? M37aPHNCVkeHUh?=
CP50-MEL-B NW\0coFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjhTWM2OD17Lke1O|gzKM7:TR?= NX\EcmMyW0GQR1XS
HT-1080 M17lbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jUbWlEPTB;OT63O|c{QSEQvF2= NWL5UZB5W0GQR1XS
HEC-1 Mlu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFyLkOzOVIh|ryP MmH6V2FPT0WU
AGS M1mwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXwTWM2OD1zMD6zO|Qh|ryP NV74TWNsW0GQR1XS
GAMG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFyLkWxOlIh|ryP NGexTYRUSU6JRWK=
SW48 M2[4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\GbWlEPTB;MUCuOVE5QSEQvF2= MoS3V2FPT0WU
U031 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TxUmlEPTB;MUCuOVkxQCEQvF2= NYPOepdIW0GQR1XS
OVCAR-5 NX3CTmYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHyU4l3UUN3ME2xNE43PDJ7IN88US=> NWTydVVbW0GQR1XS
SF295 NXjHVZlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHf0RmFKSzVyPUGwMlY4ODRizszN NVPaZ|NMW0GQR1XS
BHT-101 NUTHeWtHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof1TWM2OD1zMD63NVc4KM7:TR?= MnvHV2FPT0WU
VMRC-RCZ NGX0WIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFzLkOyNFEh|ryP M3e4fnNCVkeHUh?=
ACHN MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPFPGJKSzVyPUGxMlQzOTFizszN Ml7yV2FPT0WU
NCI-H526 NELPWXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonQTWM2OD1zMT61NFQ{KM7:TR?= M1zTTHNCVkeHUh?=
MN-60 M3\ZWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPKTWM2OD1zMT61N|kh|ryP NVixU3VDW0GQR1XS
NCI-H2291 NUfleJVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPzellKSzVyPUGxMlU1PjZizszN Mn[3V2FPT0WU
SCC-25 NHLpNZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTFzLke1OVYh|ryP NInzRpFUSU6JRWK=
SK-MEL-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33hWWlEPTB;MUGuO|Y{PyEQvF2= MV7TRW5ITVJ?
SN12C MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPVTWM2OD1zMT65N|U2KM7:TR?= M4S2dXNCVkeHUh?=
NCI-H69 NG\mPFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTaU2pDUUN3ME2xNk41OjN2IN88US=> NYHHR|JuW0GQR1XS
ME-180 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXTTWM2OD1zMj63NFU1KM7:TR?= M3TkfHNCVkeHUh?=
MC-IXC M4X1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jsR2lEPTB;MUKuO|UyQCEQvF2= M2TJWHNCVkeHUh?=
NCI-H2347 NV;1VHd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF{Lke2NVQh|ryP NVHaSlJIW0GQR1XS
M059J NVPuXXhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzycVZtUUN3ME2xNk44PzJ5IN88US=> MlHPV2FPT0WU
A2058 M1ryPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDnSIlKSzVyPUGyMlg3QDFizszN NEjISZFUSU6JRWK=
VA-ES-BJ M2jyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnKcGZKSzVyPUGyMlg4QDVizszN MUTTRW5ITVJ?
Ca9-22 NXnzb4ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfIbHROUUN3ME2xNk46PDVzIN88US=> Mn\RV2FPT0WU
KNS-42 NV\vNpNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTF{Lkm5PFQh|ryP NV3ae|lCW0GQR1XS
LoVo NV7VXIdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofYTWM2OD1zMz6yN|E{KM7:TR?= M4H2dnNCVkeHUh?=
AM-38 NGnOOlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\6TWM2OD1zMz6yOVY3KM7:TR?= MlLGV2FPT0WU
NB5 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DLVGlEPTB;MUOuN|c2OiEQvF2= MVzTRW5ITVJ?
L-363 NV;NOmRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTF|LkSwN|Mh|ryP NXH6UHJ7W0GQR1XS
SK-MEL-30 NVP3[4NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKw[JVkUUN3ME2xOE4xPjR3IN88US=> MUTTRW5ITVJ?
NCI-H1563 MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF2Lk[wN|kh|ryP Mln6V2FPT0WU
NCI-H2228 MnTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTF2Lk[wO|ch|ryP NYnaZ4dFW0GQR1XS
MFM-223 NVL1eXprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXWwcI1LUUN3ME2xOU4yQDF|IN88US=> MU\TRW5ITVJ?
LB831-BLC NHKz[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHyPHVKSzVyPUG1MlI4PjdizszN MlfhV2FPT0WU
SW872 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH4SGVKSzVyPUG1MlMxQDZizszN MXPTRW5ITVJ?
NCI-H522 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTF3LkOzNFYh|ryP NUjoS2V[W0GQR1XS
EW-1 NYDwfok4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPERo5KSzVyPUG1MlU1PjJizszN MV7TRW5ITVJ?
HN NGGzOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHWe3BUUUN3ME2xOU42QTR{IN88US=> Mn3LV2FPT0WU
SW837 Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDZTWM2OD1zNT63PFQ4KM7:TR?= NUKyW3RyW0GQR1XS
SCC-9 NF;iRlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW5TWM2OD1zNT64NVE1KM7:TR?= MVPTRW5ITVJ?
MKN7 NVfKRYM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnWdYNNUUN3ME2xOU46PzN{IN88US=> MWrTRW5ITVJ?
KYSE-410 NYDPUodrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG1SXlHUUN3ME2xOk42QTFizszN MoruV2FPT0WU
SK-N-DZ Mof5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTzTWM2OD1zNj62NVE3KM7:TR?= NVjNZm5yW0GQR1XS
COR-L105 MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDCTWM2OD1zNj62OVI5KM7:TR?= MUHTRW5ITVJ?
LB2518-MEL NXnwTFVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTF4LkizPFkh|ryP MXLTRW5ITVJ?
OVCAR-4 NFzNd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTF4Lki4OlIh|ryP M{WxenNCVkeHUh?=
TK10 NIXZPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HPbWlEPTB;MU[uPVQ4OyEQvF2= NEDmeIxUSU6JRWK=
KNS-62 M2rxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr1TWM2OD1zNj65O|c4KM7:TR?= Mm\GV2FPT0WU
RPMI-8866 MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTF5LkG3N|Ih|ryP NUHqdHVmW0GQR1XS
HuP-T4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3eyZmlEPTB;MUeuNlQ6PSEQvF2= NFSzUndUSU6JRWK=
CGTH-W-1 M1:0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTF5LkWyNVkh|ryP NFzkTGxUSU6JRWK=
T-24 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3KwW2lEPTB;MUeuOVM1PyEQvF2= NYXSNIZOW0GQR1XS
HT-3 NHmzS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTF5LkW5NVQh|ryP Mlu4V2FPT0WU
KS-1 NXyzTINUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3wTWM2OD1zNz62O|Mh|ryP Mn3mV2FPT0WU
NCI-H1792 MoT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF5Lke5PEDPxE1? MnTZV2FPT0WU
ABC-1 M2Ww[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDjfmtKSzVyPUG3MlgyPDFizszN MXLTRW5ITVJ?
BPH-1 MoPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[5WIViUUN3ME2xPE4yPjh3IN88US=> NV;BUIxIW0GQR1XS
A431 NILzRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O2ZWlEPTB;MUiuOFEzPyEQvF2= MlrNV2FPT0WU
T98G M1HCfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF6LkWxOVch|ryP MY\TRW5ITVJ?
BHY M2\X[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4K4dWlEPTB;MUiuPFY6KM7:TR?= NU\aRWRTW0GQR1XS
Capan-2 NIH5d3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\3N5FKSzVyPUG4MlkxPzhizszN MUnTRW5ITVJ?
MDA-MB-175-VII NUT1WYx4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfhTWM2OD1zOD65NlA6KM7:TR?= NHjvcZlUSU6JRWK=
CAL-27 NWi0fnBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLzTWM2OD1zOT6wOFg4KM7:TR?= M{S0VnNCVkeHUh?=
AsPC-1 NXzlb5R2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXMTWM2OD1zOT64OlU4KM7:TR?= MmPvV2FPT0WU
KU812 M33VSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXxTWM2OD1zOT65OVc{KM7:TR?= MXzTRW5ITVJ?
NCI-H441 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XQXmlEPTB;MkCuNFAyKM7:TR?= MnjTV2FPT0WU
Mewo NGfvOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC4VYRKSzVyPUKwMlEzQDhizszN M33DZXNCVkeHUh?=
SK-MEL-24 NVm2RVdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T2e2lEPTB;MkCuNVQ4PyEQvF2= NV;xZlV2W0GQR1XS
NCI-H727 NVfrRVg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn1TWM2OD1{MD6yO|A1KM7:TR?= M{m4dXNCVkeHUh?=
EKVX MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJyLk[wOkDPxE1? NGXs[FdUSU6JRWK=
RT-112 NH3SOnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoWxTWM2OD1{MD62NVIzKM7:TR?= MV;TRW5ITVJ?
CAMA-1 M2XmVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\mNIJYUUN3ME2yNE46QDB|IN88US=> Mk[xV2FPT0WU
SW900 MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJzLkCxOFkh|ryP NGTYWGlUSU6JRWK=
NCI-H23 MnrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJzLkGyO|ch|ryP NH:wdVJUSU6JRWK=
SK-PN-DW MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJzLkG2OFkh|ryP NEjzeZdUSU6JRWK=
BB30-HNC NXTHUpE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHoTWM2OD1{MT6yO|Q2KM7:TR?= NH7BdVJUSU6JRWK=
VM-CUB-1 NW\X[phHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTkTWM2OD1{MT6zOVM3KM7:TR?= MnXlV2FPT0WU
IST-MEL1 M3Lubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXvTWM2OD1{MT6zOlkzKM7:TR?= NWHvVXFoW0GQR1XS
CTB-1 NEnjTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG1O21KSzVyPUKxMlQ4PTVizszN NW\mXFVPW0GQR1XS
LCLC-103H MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJ{LkG1PFIh|ryP NVG2eYpKW0GQR1XS
PANC-03-27 M2THPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJ{LkWxOlkh|ryP NV7JWWkyW0GQR1XS
HTC-C3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljRTWM2OD1{Mj61OVU2KM7:TR?= MVTTRW5ITVJ?
TE-8 MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPtVJhKSzVyPUKzMlI2PjVizszN MUPTRW5ITVJ?
NCI-H292 NIDSUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:4R2lEPTB;MkWuN|U{PiEQvF2= MWXTRW5ITVJ?
COLO-680N MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX71UIJiUUN3ME2yOU43OzJ7IN88US=> M2T1ZnNCVkeHUh?=
KYSE-520 M1;i[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXq[mpKSzVyPUK1MlY1PCEQvF2= MmW1V2FPT0WU
NB10 M17XXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n0SGlEPTB;Mk[uN|EyPyEQvF2= MXnTRW5ITVJ?
NCI-H661 MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rNbmlEPTB;Mk[uOFcyOyEQvF2= NITp[4FUSU6JRWK=
GMS-10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3X5V2lEPTB;Mk[uPFY{QCEQvF2= M{jNTnNCVkeHUh?=
NCI-H2122 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJ4Lkm5PVgh|ryP MnT5V2FPT0WU
OVCAR-8 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:yTWM2OD1{Nz6wOlM5KM7:TR?= M1TnWHNCVkeHUh?=
DJM-1 NGf2VlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P0PGlEPTB;MkeuNVQ2PCEQvF2= NHHCUpVUSU6JRWK=
UACC-893 MoPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJ5Lkm4O|gh|ryP M37hV3NCVkeHUh?=
C8166 NG\GVHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWGz[2xRUUN3ME2yPE43QTN6IN88US=> MnzmV2FPT0WU
NCI-H1693 MlHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\Lc2lEPTB;MkiuOlk4PSEQvF2= MmjTV2FPT0WU
TYK-nu NHzFbFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LBe2lEPTB;M{CuNFM1PSEQvF2= NYPzV4ROW0GQR1XS
SW1710 NWfqXppWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zPVmlEPTB;M{CuNVI3KM7:TR?= Mn3VV2FPT0WU
A375 NIrTPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PKfGlEPTB;M{CuN|I1OyEQvF2= NHfw[HNUSU6JRWK=
HMV-II NHT5fXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\XNVZ2UUN3ME2zNU4{PTl{IN88US=> M3rpUHNCVkeHUh?=
NCI-H2087 NXjRPIxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXUTWM2OD1|MT62N|UzKM7:TR?= NIX4W29USU6JRWK=
CAL-54 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nNXGlEPTB;M{GuO|I1OSEQvF2= MlXSV2FPT0WU
HCC70 NUfUN41mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3GwOGlEPTB;M{KuNVM5PyEQvF2= NU\qSoJxW0GQR1XS
ES1 NGPxOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTOS4s{UUN3ME2zNk4{ODZ{IN88US=> NWryRXZbW0GQR1XS
NCI-H1355 MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7Dc|RzUUN3ME2zN{4zODRizszN MWrTRW5ITVJ?
CFPAC-1 MlLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W2XGlEPTB;M{OuNlM{OiEQvF2= M2f1NXNCVkeHUh?=
MKN28 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDSTGFCUUN3ME2zN{4{QDB7IN88US=> NUnHcHQ3W0GQR1XS
HDLM-2 NGXUc45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTN|Lk[5N|Eh|ryP M3[2ZXNCVkeHUh?=
PANC-10-05 Mm\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHMbXoyUUN3ME2zOE4yODF2IN88US=> MY\TRW5ITVJ?
SAS NXXlUJlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTI[WF2UUN3ME2zOE41PTZ3IN88US=> NIntUHFUSU6JRWK=
HCC1395 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFuzXXFKSzVyPUO0MlcyQDZizszN MXLTRW5ITVJ?
8305C MlfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\ne2lEPTB;M{WuPFQyPSEQvF2= NH7BVY9USU6JRWK=
KM12 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnLTWM2OD1|Nj63OVQ4KM7:TR?= MWLTRW5ITVJ?
SW1116 M4rJO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PzVWlEPTB;M{euOVk6OiEQvF2= NHL5W5NUSU6JRWK=
SK-MEL-1 NGTYd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfyTWM2OD1|OD6zN|g6KM7:TR?= MorqV2FPT0WU
HCC2218 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PNeGlEPTB;M{iuOlUyQSEQvF2= MmDlV2FPT0WU
T84 NEPT[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTmT|hKSzVyPUO4Mlc1ODlizszN NWrWeHVwW0GQR1XS
ETK-1 NGnjS|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTN7LkCyNkDPxE1? M1rK[nNCVkeHUh?=
COLO-800 NHzVdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvkUHJTUUN3ME2zPU4{QDZ6IN88US=> NFP5Z4dUSU6JRWK=
CAL-12T M1j4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nBeGlEPTB;M{muOVI5OSEQvF2= M3TzNXNCVkeHUh?=
ACN NUG3[Zh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHwUWhCUUN3ME20NE41QTFzIN88US=> MYHTRW5ITVJ?
SJSA-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnmVGtVUUN3ME20NU4yPTl4IN88US=> MUnTRW5ITVJ?
PSN1 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTRzLkG3OFkh|ryP MVjTRW5ITVJ?
D-566MG M1T2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTRzLkKwPFYh|ryP MlLHV2FPT0WU
EGI-1 M3;K[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e4RmlEPTB;NEKuOFI5KM7:TR?= M2W4UnNCVkeHUh?=
A204 MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\teGFSUUN3ME20Nk43Ozh6IN88US=> MmTCV2FPT0WU
Saos-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XV[2lEPTB;NEKuPFM3QSEQvF2= NEmw[5VUSU6JRWK=
SNU-C2B MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTR|Lk[4O|gh|ryP NEK1Z5NUSU6JRWK=
HLE MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P6OWlEPTB;NESuNFg2PiEQvF2= Mmj5V2FPT0WU
SW1463 M1rCZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHXNotKSzVyPUS0Mlk6PzFizszN M4PYU3NCVkeHUh?=
DSH1 NF\XSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTR3LkCwN|Mh|ryP M{L1e3NCVkeHUh?=
MCF7 MoHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof4TWM2OD12NT61NFUyKM7:TR?= MUjTRW5ITVJ?
K5 M164Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPZPHlnUUN3ME20OU46PDB3IN88US=> NF;wTWRUSU6JRWK=
NCI-H358 M1\hWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjKUGNKSzVyPUS3MlIyPSEQvF2= M1PybHNCVkeHUh?=
NCI-H2030 M3\aO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTR5LkKzO|Qh|ryP MkG5V2FPT0WU
SW948 NH7nN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTR5LkS2OEDPxE1? NGfGOGJUSU6JRWK=
BALL-1 NV;OdZg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTR5Lk[xOlgh|ryP MXnTRW5ITVJ?
TE-9 NFH1VpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn6Z41KSzVyPUS3Mlk2QDFizszN MlnPV2FPT0WU
SK-N-FI MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq0TWM2OD12OD6wN|U5KM7:TR?= NFG4cGdUSU6JRWK=
KALS-1 NWPmSYU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorOTWM2OD12OD6xNlg6KM7:TR?= M3rFc3NCVkeHUh?=
HO-1-N-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTR6Lke0OFUh|ryP NEHrNlNUSU6JRWK=
NCI-H2452 M4W1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofhTWM2OD12OT6xNVUzKM7:TR?= MojpV2FPT0WU
OC-314 M3S4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLBRWoxUUN3ME20PU43QDN2IN88US=> MmTXV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 When ABT-263 is administered at 100 mg/kg/day in the H345 xenograft model, significant antitumor efficacy is observed with 80% TGI and 20% of treated tumors indicating at least a 50% reduction in tumor volume. [2] Oral administration of ABT-263 alone causes complete tumor regressions in xenograft models of small-cell lung cancer and acute lymphoblastic leukemia. In xenograft models of aggressive B-cell lymphoma and multiple myeloma where ABT-263 displays modest or no single agent activity, it significantly enhances the efficacy of clinically relevant therapeutic regimens. [2]
臨床試験 ABT-263 is currently in Phase II clinical trial for the treatments of chronic lymphocytic leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Affinity determination Binding affinities (Ki or IC50) of ABT-263 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and Bcl-2 (10 nM), f-Bax (1 nM) and Bcl-w (40 nM), f-Noxa (2 nM) and Mcl-1 (40 nM), and f-Bax (1 nM) and Bcl-2-A1 (15 nM). Binding affinities for Bcl-xL are also determined using a time-resolved fluorescence resonance energy transfer assay. Bcl-xL (1 nM, His tagged) is mixed with 200 nM f-Bak, 1 nM Tb-labeled anti-His antibody, and ABT-263 at room temperature for 30 min. Fluorescence is measured on an Envision plate reader using a 340/35 nm excitation filter and 520/525 (f-Bak) and 495/510 nm (Tb-labeled anti-His antibody) emission filters.

細胞アッセイ:

[1]

細胞株 SCLC cell lines
濃度 0-1 μM
反応時間 48 hours
実験の流れ

Human tumor cell lines SCLC cell lines are maintained at 37℃ containing 5% CO2. SCLC cell lines are cultured in RPMI 1640 with 10% fetal bovine serum (FBS), 1% sodium pyruvate, 25 mM HEPES, 4.5 g/L glucose, and 1% penicillin/streptomycin. Leukemia and lymphoma cell lines are cultured in RPMI 1640 supplemented with 10% FBS and 1% penicillin/streptomycin. Cells (1-5×10 4) are treated by ABT-263 for 48 hours in 96-well culture plates in a final volume of 100 μL and cytotoxicity is assessed with the CellTiter Glo assay. In vitro cyto toxicity of ABT-263 is assayed.

動物実験:

[1]

動物モデル C.B.-17 scid-bg or C.B.-17 scid mice
製剤 Formulated in 10% ethanol, 30% polyethylene glycol 400, and 60% Phosal 50 PG
投薬量 100 mg/kg/d
投与方法 Administered via p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download ABT-263 (Navitoclax) SDF
分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS No. 923564-51-6
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 100 mg/mL (102.6 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 5% DMSO+corn oil 7mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4-​[4-​[[2-​(4-​chlorophenyl)​-​5,​5-​dimethyl-​1-​cyclohexen-​1-​yl]​methyl]​-​1-​piperazinyl]​-​N-​[[4-​[[(1R)​-​3-​(4-​morpholinyl)​-​1-​[(phenylthio)​methyl]​propyl]​amino]​-​3-​[(trifluoromethyl)​sulfonyl]​phenyl]​sulfonyl]​-benzamide

文献中の引用 (37)

Frequently Asked Questions

  • Question 1
    I would like to deliver S1001 via i.p. injection, can you suggest a vehicle solution?

    Answer: S1001 ABT-263 (Navitoclax) can be dissolved in 5% DMSO+corn oil at 7mg/ml as a clear solution.

  • Question 2
    Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

    Answer: According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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