ABT-263 (Navitoclax)

ABT-263 (Navitoclax)は一種の有効なBcl-xL、Bcl-2とBcl-w阻害剤で、無細胞試験でKi値が0.5 nM及び0.5 nM以下、1nM及び1nM以下と1nM及び1nM以下にそれぞれ分かれることですが、Mcl-1、A1と結合する作用が少し弱いです。臨床2期。

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ABT-263 (Navitoclax) 化学構造
分子量: 974.61

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製品説明

  • Compare Bcl-2 Inhibitors
    Bcl-2製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 ABT-263 (Navitoclax)は一種の有効なBcl-xL、Bcl-2とBcl-w阻害剤で、無細胞試験でKi値が0.5 nM及び0.5 nM以下、1nM及び1nM以下と1nM及び1nM以下にそれぞれ分かれることですが、Mcl-1、A1と結合する作用が少し弱いです。臨床2期。
ターゲット

Bcl-xL

Bcl-2

Bcl-w

IC50

≤ 0.5 nM (Ki)

≤1 nM (Ki)

≤ 1 nM (Ki)[1]

In vitro試験 ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. [1] A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263. [2]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
EoL-1-cell M{Pj[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TyO2lEPTB;MD6wNFY3QSEQvF2= M1na[nNCVkeHUh?=
MV-4-11 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrETWM2OD1yLkCxOVg3KM7:TR?= MWrTRW5ITVJ?
NKM-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEG2PVkh|ryP NYfvZ|kyW0GQR1XS
ML-2 NIjGZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfNfmR1UUN3ME2wMlAyQTh|IN88US=> NHfwcWRUSU6JRWK=
BV-173 NHW2clVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHQOGNKSzVyPUCuNFI{OTRizszN M4PyWXNCVkeHUh?=
RS4-11 NHTMdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEK1PFch|ryP MXLTRW5ITVJ?
HL-60 M{LBOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXm0TnRXUUN3ME2wMlAzQTB6IN88US=> NFTkOlhUSU6JRWK=
KY821 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLn[lNkUUN3ME2wMlAzQTd3IN88US=> MnXQV2FPT0WU
ECC10 M{n6Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPyS4JMUUN3ME2wMlA{Pzl{IN88US=> M4jBWXNCVkeHUh?=
NCI-H720 NV32NVlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXyWIhKSzVyPUCuNFQxOTFizszN NYr4WXQ2W0GQR1XS
QIMR-WIL M3;ScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljDTWM2OD1yLkC0Nlg4KM7:TR?= M4G3OXNCVkeHUh?=
KG-1 MmXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TETmlEPTB;MD6wOFQ5PiEQvF2= MlywV2FPT0WU
TGW NX7mdmtkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz5cI4zUUN3ME2wMlA1PjN|IN88US=> M2\YbnNCVkeHUh?=
ATN-1 M1u4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vnTmlEPTB;MD6wOFc{OyEQvF2= MWrTRW5ITVJ?
RH-18 MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXqZoZHUUN3ME2wMlA3ODR6IN88US=> NVvCU4tUW0GQR1XS
EW-18 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLSd4FQUUN3ME2wMlA3QDRzIN88US=> NHKwcnhUSU6JRWK=
NB17 M1rOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGWx[3hKSzVyPUCuNFcyOjRizszN NHmzZ41USU6JRWK=
SK-NEP-1 NXPvXFRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\JTWM2OD1yLkC3NlE{KM7:TR?= NYjWUmpXW0GQR1XS
P12-ICHIKAWA M2\sN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETSUotKSzVyPUCuNFc4PzhizszN MmnjV2FPT0WU
KARPAS-45 M4LZNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjkRpBKSzVyPUCuNFc5OTVizszN NXvIcIV3W0GQR1XS
EW-3 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmm3TWM2OD1yLkC4NFU{KM7:TR?= MYrTRW5ITVJ?
NB13 NYS3VpE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\mTVR6UUN3ME2wMlA5OjB|IN88US=> NUX0T21JW0GQR1XS
NCI-H209 NELhN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfNTWM2OD1yLkC4O|A1KM7:TR?= M37aVXNCVkeHUh?=
NCI-H1092 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMUCyO|Uh|ryP M4PaNnNCVkeHUh?=
NH-12 NULMO3hoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\rSG9KSzVyPUCuNVA4PDRizszN MUXTRW5ITVJ?
697 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3WwSWlEPTB;MD6xNFg{QSEQvF2= NYLYfINrW0GQR1XS
KE-37 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnyflN{UUN3ME2wMlEyOzdizszN M2HveHNCVkeHUh?=
MOLT-4 M1v4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFflS5JKSzVyPUCuNVUyPjlizszN NHPvU49USU6JRWK=
CHP-134 MmDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXuTWM2OD1yLkG2N|A3KM7:TR?= MnrPV2FPT0WU
D-283MED MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TEemlEPTB;MD6xO|Y5PiEQvF2= NID6Z|VUSU6JRWK=
LU-135 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnsTWM2OD1yLkG4OVUzKM7:TR?= NHe1emtUSU6JRWK=
LU-134-A NGmzfVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\FVY9qUUN3ME2wMlE5PjdzIN88US=> NF21elJUSU6JRWK=
EM-2 NHr3SGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki1TWM2OD1yLkG5PVE5KM7:TR?= NYXWcWVkW0GQR1XS
LU-139 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEH1PZpKSzVyPUCuNlA1QThizszN NXrSTZlFW0GQR1XS
ALL-PO MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofmTWM2OD1yLkKxPVg5KM7:TR?= M2GzeXNCVkeHUh?=
NB12 NHW5[nNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFuxTFFKSzVyPUCuNlMyOTVizszN NIixWnlUSU6JRWK=
KP-N-YN MmfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMkO1O|Mh|ryP M4O4S3NCVkeHUh?=
BEN NGnPSopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nEcmlEPTB;MD6yN|k3QCEQvF2= M4C5eHNCVkeHUh?=
HCC1569 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\RcnJ7UUN3ME2wMlI2OTB4IN88US=> MV3TRW5ITVJ?
HuO9 NGXuPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXMTWM2OD1yLkK2O|E2KM7:TR?= NH65NIlUSU6JRWK=
WM-115 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfOc4VIUUN3ME2wMlI4PzN6IN88US=> Mni1V2FPT0WU
CCRF-CEM MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnTfppiUUN3ME2wMlM{PTJ7IN88US=> NV2xfXYxW0GQR1XS
IST-SL1 M{HwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2frWGlEPTB;MD6zOVM1OyEQvF2= NFS5XoRUSU6JRWK=
BE-13 NXzDRXpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfS[nVKSzVyPUCuN|Y1PTlizszN MlyyV2FPT0WU
COR-L88 MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnC[FNKSzVyPUCuN|Y2PCEQvF2= MWjTRW5ITVJ?
DOHH-2 MoXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwNEGwNlMh|ryP MUnTRW5ITVJ?
A704 NHq5cFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rTUmlEPTB;MD60NlY4KM7:TR?= NFnXPGVUSU6JRWK=
KNS-81-FD MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXZbYtKSzVyPUCuOFQxOTdizszN NF64bpBUSU6JRWK=
RPMI-8226 NV;RSGdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXKTodVUUN3ME2wMlQ2PjV{IN88US=> MXTTRW5ITVJ?
TGBC24TKB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W1NWlEPTB;MD60OVc4QCEQvF2= MY\TRW5ITVJ?
NCI-H1304 MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXnTWM2OD1yLkS2NVU4KM7:TR?= MVLTRW5ITVJ?
MOLT-13 M{TRUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwNE[2NVMh|ryP MXPTRW5ITVJ?
EW-22 NYfTdGZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fVO2lEPTB;MD60OlY4OSEQvF2= NHK0bGRUSU6JRWK=
MS-1 M3LyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHL2N4hKSzVyPUCuOFY6OzNizszN NHT6V2pUSU6JRWK=
RMG-I NGD6VnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;HTWM2OD1yLkS5OFY1KM7:TR?= NFrXb2VUSU6JRWK=
NTERA-S-cl-D1 MmnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwNUCwNVkh|ryP M2m0V3NCVkeHUh?=
NCI-H1048 M1f0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nSemlEPTB;MD61NFk2OyEQvF2= M2L5bHNCVkeHUh?=
SW1417 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3zZXZKSzVyPUCuOVU1OzhizszN MV;TRW5ITVJ?
DB NF7BUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ez[WlEPTB;MD61O|A5KM7:TR?= Mn31V2FPT0WU
MEG-01 Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLuPJBKSzVyPUCuOVg{OiEQvF2= Mo[1V2FPT0WU
EW-13 NIPad5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\5OoQ4UUN3ME2wMlU5OzRzIN88US=> MXXTRW5ITVJ?
LAMA-84 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f0V2lEPTB;MD61PVIxPyEQvF2= NGDjbXdUSU6JRWK=
J-RT3-T3-5 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jxdGlEPTB;MD62NFgxQCEQvF2= MlPLV2FPT0WU
MOLT-16 NWjBcZlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vzTGlEPTB;MD62OVI3PCEQvF2= NYX2N4U3W0GQR1XS
DU-4475 NUf6WmJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7aV21KSzVyPUCuOlU1OjdizszN MXLTRW5ITVJ?
HAL-01 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfaXWprUUN3ME2wMlczPTR7IN88US=> MX;TRW5ITVJ?
RD MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1znWWlEPTB;MD63OVg6QSEQvF2= NEDQfnJUSU6JRWK=
OAW-28 M1LLOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjNTnJKSzVyPUCuO|g{PyEQvF2= MmPDV2FPT0WU
HCC38 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXRTWM2OD1yLkiwNVkh|ryP M1PkNnNCVkeHUh?=
NMC-G1 NWCxd5RiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwOEGxNlEh|ryP NWPVXZlTW0GQR1XS
EW-16 MlrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1O5cGlEPTB;MD64NVMzQCEQvF2= M1LRVHNCVkeHUh?=
DU-145 NHf0c2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwOEm5NlMh|ryP M2TXRnNCVkeHUh?=
HPAF-II M1vROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvDTWM2OD1yLkmyOlI5KM7:TR?= M1jsbXNCVkeHUh?=
A427 NH22[JlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGi1R|ZKSzVyPUCuPVMxOjJizszN MmP6V2FPT0WU
PA-1 NUXyRWU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\HTWM2OD1yLkm1OlQzKM7:TR?= NHrLZ4dUSU6JRWK=
OAW-42 NWHBO|JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7mOlNKSzVyPUCuPVYyPDZizszN MnPGV2FPT0WU
L-428 MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXXSY5KSzVyPUGuNFEzPSEQvF2= Mn\nV2FPT0WU
COLO-824 NF;HflRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrVbppJUUN3ME2xMlAyPzB6IN88US=> NFW4NWVUSU6JRWK=
P30-OHK NWXBb5dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjoeG5wUUN3ME2xMlA1Pjh6IN88US=> NHTVUHJUSU6JRWK=
NCI-H2170 M{HyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP2TWM2OD1zLkC2NlMh|ryP M2S3U3NCVkeHUh?=
HCC2998 MmjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrPdFJKSzVyPUGuNFcyOzVizszN Ml;uV2FPT0WU
NB14 M{\lRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[ySppKSzVyPUGuNVM4PDhizszN NEP2UJFUSU6JRWK=
TGBC1TKB NGrVZ|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17kR2lEPTB;MT6xOFE2OiEQvF2= Mk\1V2FPT0WU
KP-N-YS MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\VTWM2OD1zLkG2NlM3KM7:TR?= M3\uXnNCVkeHUh?=
CAL-120 NFrzd4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7XeGtKSzVyPUGuNVY1OjlizszN NF3ENotUSU6JRWK=
SBC-1 NX[0dWhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\ETWM2OD1zLkG5NFU{KM7:TR?= M4q4[XNCVkeHUh?=
C32 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTFwMUmwPFgh|ryP Mn3yV2FPT0WU
HCC2157 M4H3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M363NmlEPTB;MT6xPVQ6PCEQvF2= NXvYWXdJW0GQR1XS
COLO-792 NYnP[2NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofFTWM2OD1zLkKwNFcyKM7:TR?= Mn3QV2FPT0WU
ES7 NHf1d|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljpTWM2OD1zLkK3PVUyKM7:TR?= M{XwfHNCVkeHUh?=
HEL M2fUcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\JW4hKSzVyPUGuN|ExOjlizszN NWDqbWZKW0GQR1XS
ES4 Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonUTWM2OD1zLkO0PVk5KM7:TR?= NIDXd45USU6JRWK=
NCI-SNU-1 NInSVHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[zTWtlUUN3ME2xMlM3PTV3IN88US=> M3fqenNCVkeHUh?=
MDA-MB-415 NV\hTmFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zLPWlEPTB;MT6zPFg2KM7:TR?= M2i3RnNCVkeHUh?=
NCI-H2342 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXwSFhNUUN3ME2xMlQxOjZ7IN88US=> NHT2R3JUSU6JRWK=
NB69 M2T5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLJSVJbUUN3ME2xMlQ3OjdzIN88US=> MkTNV2FPT0WU
D-247MG NFPxTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFwNUGxNlIh|ryP M3qxdnNCVkeHUh?=
SCC-4 NUmzSVdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojvTWM2OD1zLkW5PFg4KM7:TR?= M1fKe3NCVkeHUh?=
HuH-7 M1PHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTFwNkeyPVMh|ryP MVHTRW5ITVJ?
A388 MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH6yfJBKSzVyPUGuOlg4OjRizszN MVXTRW5ITVJ?
Calu-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFwN{C2PVch|ryP MoHGV2FPT0WU
NCI-H1648 NUnXXVlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnywTWM2OD1zLkexOFE5KM7:TR?= NHnRPHVUSU6JRWK=
NCI-H2052 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTCTWM2OD1zLkeyNlAyKM7:TR?= MlLNV2FPT0WU
Ramos-2G6-4C10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXsUVBKSzVyPUGuO|M3PTZizszN MXnTRW5ITVJ?
DEL NGjXcGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLXU5ZNUUN3ME2xMlc1Pjl{IN88US=> NIX6eY9USU6JRWK=
SNU-423 NUDW[|JDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn6cVFFUUN3ME2xMlc5OTV5IN88US=> MorPV2FPT0WU
COR-L23 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkX0TWM2OD1zLke5PFc1KM7:TR?= MkfiV2FPT0WU
OMC-1 MknBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTSZo1KSzVyPUGuPFYxOTZizszN M{nsU3NCVkeHUh?=
EW-11 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwOUW2OVch|ryP MmiwV2FPT0WU
HSC-3 MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\nbYlKSzVyPUGuPVY{PjVizszN MVTTRW5ITVJ?
MLMA NVXmSYRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vJeGlEPTB;MT65OlY4PyEQvF2= NHnkcYJUSU6JRWK=
RCM-1 NGP6RZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjj[m9KSzVyPUKuNFA{QTlizszN NYTGN5NtW0GQR1XS
MFE-280 NHTwbIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\xV3VXUUN3ME2yMlAzQDR6IN88US=> M3;uO3NCVkeHUh?=
ES8 NFnzOWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTJwMkW0O|Eh|ryP MlTNV2FPT0WU
TE-11 M1\CRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzle5VLUUN3ME2yMlI6PDd|IN88US=> MoO0V2FPT0WU
HuO-3N1 Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\sZnVKSzVyPUKuOFg4QCEQvF2= MWTTRW5ITVJ?
MHH-NB-11 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPLTWM2OD1{LkWxNVU5KM7:TR?= NVfX[3F3W0GQR1XS
TGBC11TKB MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJwNUe2PFEh|ryP NIHsbmxUSU6JRWK=
HOP-92 NVjC[4F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\XbYlKSzVyPUKuOVg4PDNizszN NEj2Vo5USU6JRWK=
IGR-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwNkKwN|Uh|ryP Mm\iV2FPT0WU
GOTO MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PEOWlEPTB;Mj62OVM4PyEQvF2= M4fHSnNCVkeHUh?=
NCI-H1650 NVfXeHBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf1TWM2OD1{LkeyNlE2KM7:TR?= NELkeYRUSU6JRWK=
NCI-H1581 NYXET4xwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\Pc4cyUUN3ME2yMlc6PjhzIN88US=> MnjJV2FPT0WU
NCI-H2405 NUniR5RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJwOEK3PFIh|ryP M1fwfHNCVkeHUh?=
U-118-MG Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLINXZKSzVyPUKuPVY1QTFizszN M3LUUnNCVkeHUh?=
DoTc2-4510 MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Xt[GlEPTB;Mz6wNVQyPyEQvF2= MVfTRW5ITVJ?
NCI-H596 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvxXJlKSzVyPUOuNFQ6QTdizszN NWPESodRW0GQR1XS
MPP-89 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vmRWlEPTB;Mz6wOVY3PiEQvF2= MYXTRW5ITVJ?
GCIY MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjhTWM2OD1|LkKwOFkyKM7:TR?= NYTI[HE4W0GQR1XS
SW626 NEPvXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFizc3RKSzVyPUOuNlQ2PDNizszN NX7pS|cxW0GQR1XS
OCI-AML2 M2[5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[2U3R5UUN3ME2zMlMyOjd{IN88US=> MWTTRW5ITVJ?
NBsusSR NGLpO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjZXYxjUUN3ME2zMlM1QTN6IN88US=> MoHpV2FPT0WU
AN3-CA MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTNwNESyN|gh|ryP M4fTRXNCVkeHUh?=
EFM-19 MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jpb2lEPTB;Mz60PFM{QSEQvF2= M3;RRXNCVkeHUh?=
RVH-421 MlPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[wemlEPTB;Mz61Olg4PyEQvF2= M37DdHNCVkeHUh?=
5637 NV7YcJlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTNwNkGxNFMh|ryP M1nWZ3NCVkeHUh?=
PANC-08-13 NVy1fpptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfGNWlKSzVyPUOuOlM1PzJizszN MWjTRW5ITVJ?
H9 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHGxbYFKSzVyPUOuOlcyPDRizszN NHmwPFRUSU6JRWK=
KARPAS-299 M1viOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\kXGlEPTB;Mz62O|M3OSEQvF2= Mn3qV2FPT0WU
TE-5 NEPEZohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT1TWM2OD1|LkewO|A6KM7:TR?= MYXTRW5ITVJ?
NOS-1 M1LwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTNwN{m4N|Qh|ryP NHzidHBUSU6JRWK=
HH MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3OTWM2OD1|LkizPFY5KM7:TR?= MonCV2FPT0WU
769-P NF;sTnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwOEm1NUDPxE1? MV7TRW5ITVJ?
CHP-212 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj1ZVFKSzVyPUOuPVI2PDlizszN M{[4VnNCVkeHUh?=
NCI-H82 NFfYSVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPUTpF6UUN3ME2zMlk2QTN4IN88US=> NXrqTXV5W0GQR1XS
Mo-T Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;QTWM2OD12LkC0N|EzKM7:TR?= NFTsO5VUSU6JRWK=
BB65-RCC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i0TGlEPTB;ND6wOFM6QSEQvF2= MoHzV2FPT0WU
SW1990 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTVU2FVUUN3ME20MlA2QTB6IN88US=> MlfRV2FPT0WU
LK-2 M4H0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLBbllKSzVyPUSuNVEzQTNizszN NGnu[ohUSU6JRWK=
ES5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTRwMUO5PFUh|ryP MYXTRW5ITVJ?
JVM-3 M4T4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELCS2RKSzVyPUSuNVgzOjJizszN M1LtOXNCVkeHUh?=
RPMI-7951 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTRwMkK0NVMh|ryP NXK0[FQxW0GQR1XS
Calu-6 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XqT2lEPTB;ND6yO|g5OSEQvF2= NEXUbIZUSU6JRWK=
LC-2-ad NHP4UohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLBZW0{UUN3ME20MlI6PTZ6IN88US=> M{jYUnNCVkeHUh?=
SW954 Mor2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf6ToJmUUN3ME20MlI6PjZizszN NIe5[4hUSU6JRWK=
H-EMC-SS MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\RdGlEPTB;ND6zNVg{OSEQvF2= M1fKcnNCVkeHUh?=
ES3 M1TMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DVdWlEPTB;ND6zOVQ1OSEQvF2= Mn:xV2FPT0WU
no-11 M2fTR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fT[WlEPTB;ND6zOVU2PCEQvF2= MVrTRW5ITVJ?
LAN-6 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTRwNEWxPFkh|ryP MVTTRW5ITVJ?
FTC-133 NIDHd49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjETWM2OD12LkWzPVUh|ryP NFvjRZVUSU6JRWK=
8505C MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DicGlEPTB;ND61OFI{KM7:TR?= Ml3SV2FPT0WU
SW620 M4jBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrtTWM2OD12LkW3NFU4KM7:TR?= MnrwV2FPT0WU
BCPAP M2rZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW4dJBKSzVyPUSuOlM1QDFizszN NG\XPItUSU6JRWK=
SK-LU-1 NUHvcIFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;DclFKSzVyPUSuOlYxQDlizszN NU\aR4VHW0GQR1XS
NCI-H1623 NHPYdnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWwOVF6UUN3ME20MlcxOjJ6IN88US=> M1rUXHNCVkeHUh?=
C2BBe1 NEDESYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFy5NYZKSzVyPUSuO|QxODhizszN NXnje|FbW0GQR1XS
GP5d M3XnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLYSXBKSzVyPUSuO|g{QDhizszN NXvGVY1lW0GQR1XS
NB6 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG4XmRKSzVyPUSuPFYzODRizszN NFPtcIpUSU6JRWK=
MDA-MB-157 M3WxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfuXVJKSzVyPUSuPFg4PiEQvF2= NGnoRmxUSU6JRWK=
UMC-11 Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP2UoM6UUN3ME20Mlg5QTZ2IN88US=> NEfifI5USU6JRWK=
HCC1419 MonlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlizTWM2OD12LkmwNFY{KM7:TR?= NFr2SZhUSU6JRWK=
NCI-H2029 MnPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DQS2lEPTB;ND65OFE5PSEQvF2= MYDTRW5ITVJ?
LXF-289 M2XiOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT6TFJrUUN3ME21MlA{PzF7IN88US=> M{fmeXNCVkeHUh?=
KINGS-1 M2nEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfDTWM2OD13LkC3O|Q1KM7:TR?= NXfteoNKW0GQR1XS
HD-MY-Z MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXriOWdMUUN3ME21MlI{QTZ7IN88US=> MVPTRW5ITVJ?
ESS-1 MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzYS3FKSzVyPUWuNlU2QTdizszN NEj3U45USU6JRWK=
GI-1 M1\NTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTVwMke5NlYh|ryP MUjTRW5ITVJ?
RPMI-2650 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTVwM{[xOkDPxE1? M1fDWHNCVkeHUh?=
IA-LM M2C0cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfZWldKSzVyPUWuN|k5PzFizszN NFrGTHBUSU6JRWK=
KP-4 Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3pTWM2OD13LkS2N|M1KM7:TR?= NULPUWplW0GQR1XS
G-402 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnvRYNKSzVyPUWuOVE5PjVizszN MnP3V2FPT0WU
OS-RC-2 MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW5cW9KSzVyPUWuOVI3ODRizszN NV:4SFRTW0GQR1XS
NCI-H1155 NGn4eVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;u[WlEPTB;NT61OFk2PSEQvF2= M2XM[3NCVkeHUh?=
OE19 MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PDTmlEPTB;NT62PFYzPCEQvF2= Ml75V2FPT0WU
U-2-OS MoTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTVwOEmwNVMh|ryP MlzTV2FPT0WU
SCC-15 M3zqUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm0TWM2OD13LkmzOlYzKM7:TR?= M3ruWXNCVkeHUh?=
NCI-H630 MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPFZ|BKSzVyPUWuPVk1ODRizszN NX:3NHh[W0GQR1XS
PFSK-1 NXzoRXcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn0eVNKSzVyPU[uNFUzPTlizszN NIjIbnFUSU6JRWK=
NCI-H1770 M3;POGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTZwMkC4O|Qh|ryP NXTWNG9kW0GQR1XS
SK-MEL-3 NHTjeWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHqTWM2OD14LkSyPVE2KM7:TR?= M3T6cXNCVkeHUh?=
LB1047-RCC M3HPTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTZwNEe2NlUh|ryP M4LoS3NCVkeHUh?=
NCI-H446 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTZwNkK5NlUh|ryP NYnKUFNIW0GQR1XS
SW780 NYDLVJg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rLRmlEPTB;Nj63NFE5PSEQvF2= NHrCR3lUSU6JRWK=
NEC8 M3H6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTZwN{[2N{DPxE1? MX;TRW5ITVJ?
NOMO-1 NITZ[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e5e2lEPTB;Nj63PFEyOSEQvF2= NVe1cmZRW0GQR1XS
COLO-668 NXjaeplzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIr2R25KSzVyPU[uPFQ{QDdizszN M13KO3NCVkeHUh?=
MC116 NYDNXJliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\S[|lKSzVyPU[uPVM5QTdizszN NH21NGpUSU6JRWK=
HCC1937 NFPQV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7STWM2OD14Lkm5NlUyKM7:TR?= NW\4XGk6W0GQR1XS
NCI-N87 NWPGPFhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzQTWM2OD15LkG5Nlk{KM7:TR?= NW\nO2tJW0GQR1XS
COLO-320-HSR MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomxTWM2OD15LkKyO|M5KM7:TR?= MYPTRW5ITVJ?
HCC1806 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3mzW2lEPTB;Nz6yOlA1PCEQvF2= MYrTRW5ITVJ?
OVCAR-3 Mk\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDwTWM2OD15LkOzNFM5KM7:TR?= M3PqN3NCVkeHUh?=
NUGC-3 Ml3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3IWoZmUUN3ME23MlM6Pjl2IN88US=> NX\C[nR1W0GQR1XS
SW1783 NVjSWXBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPYTWM2OD15LkSzNVc2KM7:TR?= NWflbZJSW0GQR1XS
GCT M2W3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILwb4RKSzVyPUeuOVY6ODZizszN MmDPV2FPT0WU
NCI-H2126 NH\NVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3QTWM2OD15LkezOlI2KM7:TR?= NX;qcFBzW0GQR1XS
MEL-HO NYjE[3JQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHlb|FKSzVyPUeuO|cxPTRizszN NGf5[nlUSU6JRWK=
CAPAN-1 NUftRY5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vaemlEPTB;Nz63O|M2PyEQvF2= NH;MXZJUSU6JRWK=
SW756 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;HVYxTUUN3ME23Mlc5OzN|IN88US=> MmPUV2FPT0WU
SKG-IIIa NHXjTpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXpTWM2OD15LkixPFkzKM7:TR?= NHO5[VFUSU6JRWK=
HCE-T MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;ESpNOUUN3ME23Mlg4Pzh|IN88US=> MXXTRW5ITVJ?
Ca-Ski NFrNOG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjBfIZKSzVyPUeuPVk{QDNizszN MUjTRW5ITVJ?
COLO-684 M33DXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\CcnFKSzVyPUiuNFE5OThizszN MXrTRW5ITVJ?
KYSE-70 NFnIPY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFuyV4tKSzVyPUiuNFc4OjlizszN MVPTRW5ITVJ?
TI-73 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRThwMkW4OVEh|ryP NHzudZBUSU6JRWK=
BT-20 NUi2dFJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW2b|lNUUN3ME24MlI3ODV{IN88US=> MXTTRW5ITVJ?
MHH-ES-1 M2iwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f6OmlEPTB;OD61NVg{PCEQvF2= MWDTRW5ITVJ?
TE-12 MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jD[mlEPTB;OD61PVk{OSEQvF2= NWOy[5hXW0GQR1XS
YH-13 NFfL[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6yU2VKSzVyPUiuOlExODhizszN NID2[WRUSU6JRWK=
SF126 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRThwOEO4OlUh|ryP M2XXUnNCVkeHUh?=
J82 NIL6WIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRThwOUCwN|gh|ryP M4HOW3NCVkeHUh?=
RCC10RGB NXrS[|RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDQTWM2OD16Lkm5OVYyKM7:TR?= NVW4U|ZWW0GQR1XS
SK-UT-1 NH\hbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[3NGpKSzVyPUmuNFQ6PDVizszN MWjTRW5ITVJ?
LB2241-RCC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TaeWlEPTB;OT6xPVE{PyEQvF2= NULvPJhbW0GQR1XS
LB996-RCC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHHTWM2OD17LkG5PFkh|ryP MV\TRW5ITVJ?
EPLC-272H MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTlwM{e2OVch|ryP M2jjUHNCVkeHUh?=
CTV-1 M{Wwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLLTWM2OD17LkW2OVMzKM7:TR?= MXnTRW5ITVJ?
HSC-2 M{LZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnTZ3lKSzVyPUmuOVc2PSEQvF2= MkG4V2FPT0WU
SK-MEL-28 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rEUGlEPTB;OT62NVg6OyEQvF2= MnT2V2FPT0WU
MMAC-SF MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfTT2VKSzVyPUmuOlg4PSEQvF2= MUTTRW5ITVJ?
CP50-MEL-B MmHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTlwN{W3PFIh|ryP M{LmV3NCVkeHUh?=
HT-1080 NVLOVmhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW3fo5KSzVyPUmuO|c4OzlizszN MV7TRW5ITVJ?
HEC-1 NGLTOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFyLkOzOVIh|ryP MVLTRW5ITVJ?
AGS MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTFyLkO3OEDPxE1? NFr2XI5USU6JRWK=
GAMG NUHQVXA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFyLkWxOlIh|ryP NETRXHBUSU6JRWK=
SW48 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXH3XmQ4UUN3ME2xNE42OTh7IN88US=> M17Ed3NCVkeHUh?=
U031 NF;XU45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjuTWM2OD1zMD61PVA5KM7:TR?= MXTTRW5ITVJ?
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SNU-C2B MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnv1TWM2OD12Mz62PFc5KM7:TR?= NU\ONVRqW0GQR1XS
HLE NUfLdoFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3nXIFKSzVyPUS0MlA5PTZizszN MoDKV2FPT0WU
SW1463 NVjxVYQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTR2Lkm5O|Eh|ryP NE\rbndUSU6JRWK=
DSH1 MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf3ZXp{UUN3ME20OU4xODN|IN88US=> NGX2c|lUSU6JRWK=
MCF7 MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HUc2lEPTB;NEWuOVA2OSEQvF2= NWricHZZW0GQR1XS
K5 NUTrR2RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfmb3NKSzVyPUS1Mlk1ODVizszN MkDsV2FPT0WU
NCI-H358 NFHNcldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPXTWM2OD12Nz6yNVUh|ryP M2eybHNCVkeHUh?=
NCI-H2030 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33rXmlEPTB;NEeuNlM4PCEQvF2= NWj5RVdbW0GQR1XS
SW948 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDhdZU1UUN3ME20O{41PjRizszN NWTyWJFQW0GQR1XS
BALL-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjXb5FRUUN3ME20O{43OTZ6IN88US=> MV3TRW5ITVJ?
TE-9 NWD2VIdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTR5Lkm1PFEh|ryP NFH2O4xUSU6JRWK=
SK-N-FI MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XUNGlEPTB;NEiuNFM2QCEQvF2= NEixW2ZUSU6JRWK=
KALS-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTR6LkGyPFkh|ryP NHHMSmNUSU6JRWK=
HO-1-N-1 NEfPdVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjCenJwUUN3ME20PE44PDR3IN88US=> NEnweI1USU6JRWK=
NCI-H2452 NF3vbY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTR7LkGxOVIh|ryP NYDxfIxoW0GQR1XS
OC-314 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Xzb2lEPTB;NEmuOlg{PCEQvF2= MXzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 When ABT-263 is administered at 100 mg/kg/day in the H345 xenograft model, significant antitumor efficacy is observed with 80% TGI and 20% of treated tumors indicating at least a 50% reduction in tumor volume. [2] Oral administration of ABT-263 alone causes complete tumor regressions in xenograft models of small-cell lung cancer and acute lymphoblastic leukemia. In xenograft models of aggressive B-cell lymphoma and multiple myeloma where ABT-263 displays modest or no single agent activity, it significantly enhances the efficacy of clinically relevant therapeutic regimens. [2]
臨床試験 ABT-263 is currently in Phase II clinical trial for the treatments of chronic lymphocytic leukemia.
特集

プロトコル (参考用のみ)

キナーゼアッセイ:

[1]

Affinity determination Binding affinities (Ki or IC50) of ABT-263 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and Bcl-2 (10 nM), f-Bax (1 nM) and Bcl-w (40 nM), f-Noxa (2 nM) and Mcl-1 (40 nM), and f-Bax (1 nM) and Bcl-2-A1 (15 nM). Binding affinities for Bcl-xL are also determined using a time-resolved fluorescence resonance energy transfer assay. Bcl-xL (1 nM, His tagged) is mixed with 200 nM f-Bak, 1 nM Tb-labeled anti-His antibody, and ABT-263 at room temperature for 30 min. Fluorescence is measured on an Envision plate reader using a 340/35 nm excitation filter and 520/525 (f-Bak) and 495/510 nm (Tb-labeled anti-His antibody) emission filters.

細胞アッセイ:

[1]

細胞株 SCLC cell lines
濃度 0-1 μM
反応時間 48 hours
実験の流れ

Human tumor cell lines SCLC cell lines are maintained at 37℃ containing 5% CO2. SCLC cell lines are cultured in RPMI 1640 with 10% fetal bovine serum (FBS), 1% sodium pyruvate, 25 mM HEPES, 4.5 g/L glucose, and 1% penicillin/streptomycin. Leukemia and lymphoma cell lines are cultured in RPMI 1640 supplemented with 10% FBS and 1% penicillin/streptomycin. Cells (1-5×10 4) are treated by ABT-263 for 48 hours in 96-well culture plates in a final volume of 100 μL and cytotoxicity is assessed with the CellTiter Glo assay. In vitro cyto toxicity of ABT-263 is assayed.

動物実験:

[1]

動物モデル C.B.-17 scid-bg or C.B.-17 scid mice
製剤 Formulated in 10% ethanol, 30% polyethylene glycol 400, and 60% Phosal 50 PG
投薬量 100 mg/kg/d
投与方法 Administered via p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download ABT-263 (Navitoclax) SDF
分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS No. 923564-51-6
保管 3年-20℃
2年-80℃in solvent
別名 N/A
溶解度 (25°C) * In vitro DMSO 100 mg/mL (102.6 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 5% DMSO+corn oil 7mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 4-​[4-​[[2-​(4-​chlorophenyl)​-​5,​5-​dimethyl-​1-​cyclohexen-​1-​yl]​methyl]​-​1-​piperazinyl]​-​N-​[[4-​[[(1R)​-​3-​(4-​morpholinyl)​-​1-​[(phenylthio)​methyl]​propyl]​amino]​-​3-​[(trifluoromethyl)​sulfonyl]​phenyl]​sulfonyl]​-benzamide

文献中の引用 (37)

Frequently Asked Questions

  • Question 1
    Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

    Answer: According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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