17-AAG (Tanespimycin) 化学構造
分子量: 585.69

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Quality Control & MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 17-AAG (Tanespimycin)は、5nMのIC50による強力な熱ショックタンパク質90(Hsp90)阻害剤です。
ターゲット HSP90
IC50 5 nM [1]
In vitro試験 17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A549 M1rER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMECwN|A{KM7:TR?= MVrTRW5ITVJ?
IST-MEL1 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7XN4NKSzVyPUCuNFAxPDB5IN88US=> MlrGV2FPT0WU
NCI-SNU-1 NFrxTFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfOTYFKSzVyPUCuNFAzODdizszN MlzoV2FPT0WU
FADU MmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnsZ3B[UUN3ME2wMlAxOjB7IN88US=> NXPlfXZrW0GQR1XS
C32 Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMECzNFQh|ryP MYjTRW5ITVJ?
D-566MG NVrXUGhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3mVVRKSzVyPUCuNFA{QSEQvF2= MlzQV2FPT0WU
LXF-289 NGLW[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\i[pZKSzVyPUCuNFA1OTlizszN NYHmSJRwW0GQR1XS
HGC-27 NUjoR3psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWKyZlFqUUN3ME2wMlAxPTFizszN NHHEUJZUSU6JRWK=
RPMI-7951 NIftd|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrXTGdJUUN3ME2wMlAxPzF5IN88US=> NX\mXmtXW0GQR1XS
HSC-3 NXPmNm9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEC5Nlkh|ryP NFm5WWFUSU6JRWK=
MIA-PaCa-2 M2HKfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jV[WlEPTB;MD6wNVAxQSEQvF2= MonjV2FPT0WU
KS-1 NWi4cpB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\4S2lEPTB;MD6wNVM2PSEQvF2= NWnMVo1wW0GQR1XS
CAL-51 M3e2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnvUnk{UUN3ME2wMlAyPDB3IN88US=> MojCV2FPT0WU
MDA-MB-361 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEG0PVUh|ryP M3jKeHNCVkeHUh?=
TI-73 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi5bW5WUUN3ME2wMlAyPzl4IN88US=> MX\TRW5ITVJ?
AGS NYnhV|YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkG4TWM2OD1yLkCxPVM5KM7:TR?= Ml7iV2FPT0WU
NCI-H460 NID5WFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7NOmxGUUN3ME2wMlAyQTd2IN88US=> MXTTRW5ITVJ?
A204 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT2fZByUUN3ME2wMlAzOjR7IN88US=> Mmr0V2FPT0WU
CHL-1 NXfJRWRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PINGlEPTB;MD6wNlI2OSEQvF2= M2\jSXNCVkeHUh?=
DU-4475 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXpeYFuUUN3ME2wMlAzOjZzIN88US=> MoG3V2FPT0WU
CGTH-W-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT6NW1GUUN3ME2wMlAzOzR7IN88US=> NWPme2U5W0GQR1XS
HCC2218 MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEK0PVQh|ryP NFLrd|hUSU6JRWK=
A2780 NVL6[pZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDPTWM2OD1yLkCyOVMyKM7:TR?= M{LK[XNCVkeHUh?=
NCI-H720 M1qzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn34TWM2OD1yLkCyOVQ3KM7:TR?= NHvNO3NUSU6JRWK=
NCI-N87 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fLcmlEPTB;MD6wNlU6OyEQvF2= MWfTRW5ITVJ?
CHP-212 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEK2Nlgh|ryP NH6yWHJUSU6JRWK=
NCI-H23 M123Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvSfmFZUUN3ME2wMlAzPjZ3IN88US=> MYDTRW5ITVJ?
D-263MG MkGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrMe49KSzVyPUCuNFI4QDZizszN MnfoV2FPT0WU
ME-180 M4\Gfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHj5[IRKSzVyPUCuNFI5QTFizszN NYm4TXE6W0GQR1XS
SW982 NHfTc2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTlTWM2OD1yLkCyPVk6KM7:TR?= NXXYWVJUW0GQR1XS
OE19 NG\IbXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEOwO|ch|ryP NYLUd5JwW0GQR1XS
SK-LU-1 NWf3NW5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrsb45KSzVyPUCuNFMxQDJizszN NH3ncopUSU6JRWK=
H4 MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LDXGlEPTB;MD6wN|A6KM7:TR?= MmnCV2FPT0WU
HT-144 NXn5O2xyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fMSmlEPTB;MD6wN|A6OyEQvF2= M13uNHNCVkeHUh?=
SK-UT-1 MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PVPGlEPTB;MD6wN|E4QCEQvF2= MX;TRW5ITVJ?
D-336MG NWjkUoZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP6W2pKSzVyPUCuNFM{ODlizszN MoPSV2FPT0WU
MDA-MB-175-VII MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\xTWM2OD1yLkCzN|U1KM7:TR?= M1KzTnNCVkeHUh?=
GAMG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEO0N|Uh|ryP MXnTRW5ITVJ?
CP50-MEL-B NV3tR3NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEO0OUDPxE1? Ml;FV2FPT0WU
OVCAR-5 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OxW2lEPTB;MD6wN|Q5KM7:TR?= M1LnfHNCVkeHUh?=
SK-MES-1 NUPNOZk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrEOHBNUUN3ME2wMlA{PjB4IN88US=> NHj4cJhUSU6JRWK=
VM-CUB-1 M2G3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj6TWM2OD1yLkCzOlU4KM7:TR?= M3z3XnNCVkeHUh?=
WM-115 NVXm[JM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDNTWM2OD1yLkCzO|YzKM7:TR?= MmLIV2FPT0WU
DSH1 NIizRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEO4NFch|ryP MWLTRW5ITVJ?
Becker MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEO4PFUh|ryP MnLLV2FPT0WU
SW962 NX[2TIRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrhdYdzUUN3ME2wMlA{QTR3IN88US=> NWLBb4l7W0GQR1XS
TYK-nu MlnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf2SoFKSzVyPUCuNFM6QDVizszN NH7sV4FUSU6JRWK=
HO-1-N-1 NWOwOo1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37RNmlEPTB;MD6wOFAzOSEQvF2= NWPybFQ4W0GQR1XS
T98G Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMESxNFMh|ryP Mk\aV2FPT0WU
ACN Ml:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLRTWM2OD1yLkC0NVYzKM7:TR?= M3;tWXNCVkeHUh?=
SW780 NEXhfI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT2TWM2OD1yLkC0NlA{KM7:TR?= M4HpWXNCVkeHUh?=
Detroit562 NFTMOWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLOfFE4UUN3ME2wMlA1OjN7IN88US=> NVnmT3lWW0GQR1XS
BB49-HNC NGn5c4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUW3V|BsUUN3ME2wMlA1OjR|IN88US=> M1zPcHNCVkeHUh?=
HN MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLhZ5JKSzVyPUCuNFQzPzJizszN NIrVR5pUSU6JRWK=
H9 MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMESzO|Eh|ryP MonYV2FPT0WU
VA-ES-BJ MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTrVpdOUUN3ME2wMlA1PDR5IN88US=> NXrCbZJjW0GQR1XS
MEL-JUSO MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULzV|FRUUN3ME2wMlA1PDd3IN88US=> MknzV2FPT0WU
BT-474 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnMbZJKSzVyPUCuNFQ2KM7:TR?= MWTTRW5ITVJ?
CaR-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL6W|BKSzVyPUCuNFQ2PDlizszN MlPMV2FPT0WU
PSN1 MkPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL6UFJKSzVyPUCuNFQ3ODNizszN NILaOIhUSU6JRWK=
KYSE-510 M333U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC1bY1DUUN3ME2wMlA1PjR7IN88US=> NWrENYdLW0GQR1XS
KP-4 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr1XXhKSzVyPUCuNFQ4PTNizszN MnGzV2FPT0WU
KYSE-410 NV:1VpFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2G2eGlEPTB;MD6wOFc4OiEQvF2= MYTTRW5ITVJ?
G-402 M4XHc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDpe2dKSzVyPUCuNFQ4QDlizszN NE\vN|hUSU6JRWK=
DOK NF62VnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LYdGlEPTB;MD6wOFkxOiEQvF2= NGLiO21USU6JRWK=
COR-L88 NETGRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDvNmtzUUN3ME2wMlA1QTF{IN88US=> M2r1T3NCVkeHUh?=
SKG-IIIa NV3LV5c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rmNmlEPTB;MD6wOFk5PiEQvF2= MlTxV2FPT0WU
AN3-CA NE\rW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXU[JZ2UUN3ME2wMlA2KM7:TR?= MUPTRW5ITVJ?
SW48 MlXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTZVmtEUUN3ME2wMlA2ODN7IN88US=> MXnTRW5ITVJ?
YKG-1 NHG0NGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHwfoFoUUN3ME2wMlA2ODdzIN88US=> M1\GXHNCVkeHUh?=
KYSE-150 M4OwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;CWGlEPTB;MD6wOVI{PSEQvF2= M4DBdHNCVkeHUh?=
HuO-3N1 MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DyPWlEPTB;MD6wOVI{PyEQvF2= M3;veHNCVkeHUh?=
LB1047-RCC MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vaR2lEPTB;MD6wOVI6PiEQvF2= MlzsV2FPT0WU
NCI-H2030 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;PNZdHUUN3ME2wMlA2PDF2IN88US=> MmqzV2FPT0WU
YH-13 NFHrfmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7kTWM2OD1yLkC1O|IzKM7:TR?= NW\oSmhOW0GQR1XS
5637 NVm4eIlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEW3OEDPxE1? MUXTRW5ITVJ?
LOXIMVI NYD2RXN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITo[45KSzVyPUCuNFU5PzJizszN NEP4UXJUSU6JRWK=
GT3TKB M2LMfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEW5OFIh|ryP MYLTRW5ITVJ?
TCCSUP MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULUSop3UUN3ME2wMlA2QTZ2IN88US=> NVrxfHRWW0GQR1XS
EPLC-272H MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK5eWRuUUN3ME2wMlA3OjB3IN88US=> NU\Ie5RoW0GQR1XS
LU-99A MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwME[yN|ch|ryP NVrITpRqW0GQR1XS
NCI-H1755 MnO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjpRZllUUN3ME2wMlA3OzRzIN88US=> NGfJPHVUSU6JRWK=
KM12 NVLuOYJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH4TWM2OD1yLkC2N|Q5KM7:TR?= NGG4NGFUSU6JRWK=
SF295 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zOTGlEPTB;MD6wOlQ2OiEQvF2= M13mSXNCVkeHUh?=
MZ2-MEL NYWxN5AzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInISGRKSzVyPUCuNFY2PTNizszN MVzTRW5ITVJ?
HEC-1 Mn7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwME[1PFgh|ryP NGS4R3hUSU6JRWK=
SW684 M4nFSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfRdZNJUUN3ME2wMlA3PTlzIN88US=> MVLTRW5ITVJ?
SF539 M2nmbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrxXIhKSzVyPUCuNFY3QDFizszN MmqzV2FPT0WU
GMS-10 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwME[2PVkh|ryP MlPlV2FPT0WU
MV-4-11 Ml7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XubWlEPTB;MD6wOlgxOyEQvF2= NH;hPItUSU6JRWK=
HT-29 MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwME[5NVkh|ryP NIfTN2FUSU6JRWK=
23132-87 Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwME[5OUDPxE1? NHz2eIRUSU6JRWK=
SW620 MnXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\4dWdKSzVyPUCuNFcxOjZizszN MmToV2FPT0WU
HCC1806 NH33WGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEexN|Eh|ryP MWPTRW5ITVJ?
Hs-578-T MnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[0OZlJUUN3ME2wMlA4OjB6IN88US=> NUTYUIcxW0GQR1XS
A2058 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmze5hKSzVyPUCuNFczOjhizszN NYjmfpV{W0GQR1XS
MEL-HO NXLlcJAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTnTWM2OD1yLkC3NlU2KM7:TR?= NWWyUXd{W0GQR1XS
HCC2998 MknkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEezOFch|ryP NHHUVXZUSU6JRWK=
HuO9 NHnBPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXpbIpKSzVyPUCuNFc2QDlizszN M3uxbXNCVkeHUh?=
CAL-39 NIO3R3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHpR2pKSzVyPUCuNFc4PjZizszN MoiwV2FPT0WU
M14 NH7HO5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfLPFZNUUN3ME2wMlA4QTF|IN88US=> NV76XlhuW0GQR1XS
BFTC-909 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLnPW1tUUN3ME2wMlA4QTZ7IN88US=> NE\Qd5pUSU6JRWK=
TE-11 NE\tVGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7YV3ZKSzVyPUCuNFc6QTZizszN NXvHd4cyW0GQR1XS
TGBC1TKB NUDxcmg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjtTWM2OD1yLkC4NFQ{KM7:TR?= NGLROlVUSU6JRWK=
L-363 M4C4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELwWFJKSzVyPUCuNFgzODZizszN NUHHUnNFW0GQR1XS
A431 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojJTWM2OD1yLkC4NlEh|ryP NHjtRmJUSU6JRWK=
MKN45 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OzeWlEPTB;MD6wPFIyQSEQvF2= MUTTRW5ITVJ?
HT-1080 NYHldGJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjXc4RKSzVyPUCuNFg1OzlizszN NY[2N5VSW0GQR1XS
OVCAR-8 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEi2NlIh|ryP NVLofmptW0GQR1XS
LCLC-97TM1 MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEi3Nlgh|ryP MVzTRW5ITVJ?
M059J MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEmwNlch|ryP NYS0[oF6W0GQR1XS
SK-MEL-2 NXXyO4ljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrvTWM2OD1yLkC5NFYh|ryP NXX3ZY9[W0GQR1XS
TE-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r0bGlEPTB;MD6wPVIxPCEQvF2= M2PPfnNCVkeHUh?=
KYSE-180 M363Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\keFU3UUN3ME2wMlA6OjZ{IN88US=> NV\sOWJVW0GQR1XS
D-247MG M1;ySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETaUIVKSzVyPUCuNFk1PTVizszN MVnTRW5ITVJ?
8-MG-BA NWq1em55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7jWW9KSzVyPUCuNFk1PzJizszN MkXwV2FPT0WU
NCI-H1792 NGe0ZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMEm2NVgh|ryP M{jRbnNCVkeHUh?=
MCF7 NGrlZWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEm2O|ch|ryP MnHIV2FPT0WU
NCI-H2122 NIfIWVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LBdGlEPTB;MD6wPVc1PSEQvF2= MWfTRW5ITVJ?
EFO-27 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Hye2lEPTB;MD6wPVk6PyEQvF2= MlGxV2FPT0WU
LB2241-RCC NVmwVJJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYG2VpF{UUN3ME2wMlExODV2IN88US=> NH;YU2NUSU6JRWK=
SN12C NX\BO3d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMUCxNFch|ryP MX;TRW5ITVJ?
A498 M3GycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXrTWM2OD1yLkGwNVgh|ryP M1HMTHNCVkeHUh?=
PANC-03-27 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjWblVCUUN3ME2wMlExOjh4IN88US=> NV3GcYJDW0GQR1XS
NCI-H1581 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\6S4lNUUN3ME2wMlExOjlizszN NHzlbFFUSU6JRWK=
U-87-MG NU\mTJJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fsTGlEPTB;MD6xNFMxPyEQvF2= MojFV2FPT0WU
G-401 NHnNXXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfWd|lKSzVyPUCuNVA{PTNizszN M1P1fHNCVkeHUh?=
SiHa NIW4W21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPJTnBzUUN3ME2wMlExPDh4IN88US=> MnjaV2FPT0WU
U251 M3Tkfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHHfHJKSzVyPUCuNVA2OjVizszN NWLzUlZ[W0GQR1XS
MMAC-SF MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMUC1N|Eh|ryP NX3lfGoyW0GQR1XS
BB65-RCC NVe4c3lKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[zZpRMUUN3ME2wMlExPTV2IN88US=> NVr5UmxLW0GQR1XS
NKM-1 NVTXN5I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTETWM2OD1yLkGwOlY3KM7:TR?= M3TyfXNCVkeHUh?=
HD-MY-Z MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnMRnZKSzVyPUCuNVA5PzNizszN MojEV2FPT0WU
TGBC11TKB NWPPbVEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMUC5NFMh|ryP M1TUR3NCVkeHUh?=
COLO-679 NHH3XGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnOzTWM2OD1yLkGxNlEyKM7:TR?= NVrzbmFlW0GQR1XS
TE-8 M3fVTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\GRmlEPTB;MD6xNVI3PCEQvF2= NWnue3M6W0GQR1XS
SK-MEL-28 NXS3OXo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\vTWM2OD1yLkGxN|IyKM7:TR?= NYj5eWVPW0GQR1XS
SH-4 NUWxNo9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP5[4pSUUN3ME2wMlEyOzV4IN88US=> M33GOXNCVkeHUh?=
KALS-1 M4rVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLkRnhCUUN3ME2wMlEyOzl|IN88US=> M{HZcnNCVkeHUh?=
RKO MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\DcWlEPTB;MD6xNVc3PCEQvF2= NWDjWXFqW0GQR1XS
OMC-1 NInNfXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTsZXNZUUN3ME2wMlEyPzl5IN88US=> NEW0Z2FUSU6JRWK=
BT-549 M4Hu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q1SmlEPTB;MD6xNVc6QSEQvF2= NFKwWnlUSU6JRWK=
NCI-H28 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHju[XFKSzVyPUCuNVE5OTdizszN MoDsV2FPT0WU
RXF393 MkPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMUG5PFIh|ryP MXnTRW5ITVJ?
COLO-829 M2flemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMUKwNFUh|ryP MoXZV2FPT0WU
HMV-II M{LhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmxXIlKSzVyPUCuNVIxOiEQvF2= MXrTRW5ITVJ?
SW1990 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfFTWM2OD1yLkGyNVU4KM7:TR?= NFfJNW9USU6JRWK=
NCI-H1437 NUT5ZXFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPHSWpKSzVyPUCuNVIyPTdizszN MW\TRW5ITVJ?
SNB75 NG[3RXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi3S21QUUN3ME2wMlEzOTZ7IN88US=> MVvTRW5ITVJ?
EW-3 NX\TV4FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzYTWM2OD1yLkGyOlYyKM7:TR?= MorJV2FPT0WU
SAS NEf1O|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vsVmlEPTB;MD6xNlY6KM7:TR?= NGfERZBUSU6JRWK=
NCI-H1666 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMUK3O|Qh|ryP MlzkV2FPT0WU
A375 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rxSGlEPTB;MD6xNlc4QCEQvF2= NFztV2VUSU6JRWK=
CAMA-1 MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK0ZZhKSzVyPUCuNVI6OjRizszN NG\lcFhUSU6JRWK=
HuP-T4 M3vQOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLzOpNKSzVyPUCuNVI6PDNizszN Mm\uV2FPT0WU
NCI-H292 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDBTWM2OD1yLkGzNVEh|ryP MUfTRW5ITVJ?
PC-14 Ml33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3oSo1KSzVyPUCuNVMzOTFizszN NV\vWVZHW0GQR1XS
BPH-1 NIfsN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rtPGlEPTB;MD6xN|QyKM7:TR?= MYDTRW5ITVJ?
GAK MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XjemlEPTB;MD6xN|U3PyEQvF2= NWP0VpM1W0GQR1XS
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SK-MEL-24 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXKTWM2OD1yLkGzPFch|ryP MkfaV2FPT0WU
LB831-BLC NFe3SI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PmOWlEPTB;MD6xN|g5OyEQvF2= NWC0NmpuW0GQR1XS
NCI-H2452 M4\BOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMUO5OVYh|ryP NUX2O2I4W0GQR1XS
RT-112 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG2bXdKSzVyPUCuNVQxOzVizszN M4DNRXNCVkeHUh?=
GP5d NF73Z4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLlTWM2OD1yLkG0NVA1KM7:TR?= M{XRS3NCVkeHUh?=
LC-2-ad NXLueoZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPnSmdsUUN3ME2wMlE1OTJzIN88US=> MmHjV2FPT0WU
MPP-89 M3O0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvpNFRKSzVyPUCuNVQyOjVizszN NHLYRmNUSU6JRWK=
NUGC-3 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\nUodKSzVyPUCuNVQ1PzhizszN MVTTRW5ITVJ?
GI-1 NGPhO3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPZbGIzUUN3ME2wMlE1PTV6IN88US=> M2D3N3NCVkeHUh?=
HCC1419 M4nUZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTpTWM2OD1yLkG0OVc3KM7:TR?= MkLBV2FPT0WU
SW1573 NXLVXnJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe3TWM2OD1yLkG0O|U5KM7:TR?= MkfVV2FPT0WU
NCI-H2347 M1\zRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMUS4N|kh|ryP NGToXFFUSU6JRWK=
Mewo NYrsTWdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPWTWM2OD1yLkG0PFg6KM7:TR?= NX7u[4hqW0GQR1XS
639-V NGrNU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rGWmlEPTB;MD6xOVAyOyEQvF2= M3LJRXNCVkeHUh?=
AsPC-1 NEPROIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XQbGlEPTB;MD6xOVIzPSEQvF2= MlW5V2FPT0WU
NCI-H1648 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT5TWM2OD1yLkG1NlMzKM7:TR?= MYXTRW5ITVJ?
786-0 MnrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7pTWM2OD1yLkG1N|gyKM7:TR?= MUjTRW5ITVJ?
ETK-1 NVS4TVlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPDWINKSzVyPUCuNVU6KM7:TR?= NGriR4FUSU6JRWK=
BxPC-3 NFu3SZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTBfXdKSzVyPUCuNVU6PjZizszN MX\TRW5ITVJ?
CAL-62 M3;QUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXMRodKSzVyPUCuNVYyPjlizszN NFz4PIJUSU6JRWK=
HCC1937 NHrtO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TOcmlEPTB;MD6xOlI4PSEQvF2= NYLCO|lOW0GQR1XS
NCI-H1299 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMU[yPFUh|ryP MlzKV2FPT0WU
SW1088 NXPjZlZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[5[2lEPTB;MD6xOlQyOyEQvF2= MW\TRW5ITVJ?
FTC-133 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzuTWM2OD1yLkG2OVQh|ryP NFO4fXVUSU6JRWK=
OC-314 NWnFZVJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMU[2PUDPxE1? M1nyOHNCVkeHUh?=
SCC-9 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;UfGxKSzVyPUCuNVY4OTZizszN MnzVV2FPT0WU
HT-1376 NGfkV3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHf1T2RKSzVyPUCuNVY6OzZizszN Mmi5V2FPT0WU
U-2-OS M{PicWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjPfYlKSzVyPUCuNVcyPzNizszN MYfTRW5ITVJ?
COLO-824 NYf1VmZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rERWlEPTB;MD6xO|I6PCEQvF2= MVXTRW5ITVJ?
BB30-HNC NHHyVWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr4TWM2OD1yLkG3N|Mh|ryP Mn\BV2FPT0WU
NCI-H2087 M3jtW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfCTWM2OD1yLkG3N|Y5KM7:TR?= Mly1V2FPT0WU
NCI-H2170 NGO5XldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn22TWM2OD1yLkG3OVM3KM7:TR?= NYD2R|BwW0GQR1XS
SK-OV-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMUe1O|Eh|ryP NGfQNGVUSU6JRWK=
MZ7-mel MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrGRWtGUUN3ME2wMlE4PjR7IN88US=> M{HQfXNCVkeHUh?=
NCI-H650 NFzseHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfITWM2OD1yLkG3OlgzKM7:TR?= NYrNOXBRW0GQR1XS
KOSC-2 NX[yVYl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\BS2lEPTB;MD6xO|c{PCEQvF2= NF\BOYpUSU6JRWK=
SCC-4 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq5TWM2OD1yLkG3O|c4KM7:TR?= MW\TRW5ITVJ?
MDA-MB-157 M2XNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHHVZFKSzVyPUCuNVgxQDJizszN MYDTRW5ITVJ?
KYSE-520 M33oVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDLc|dRUUN3ME2wMlE5OiEQvF2= M4i4enNCVkeHUh?=
LK-2 MnizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XPR2lEPTB;MD6xPFMxOyEQvF2= NF[3S49USU6JRWK=
KNS-81-FD NFzzZphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jlcGlEPTB;MD6xPFM6PCEQvF2= MYLTRW5ITVJ?
IGROV-1 MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDYTWM2OD1yLkG4OFQ{KM7:TR?= NFXLeZNUSU6JRWK=
DEL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\tSWlEPTB;MD6xPFQ2KM7:TR?= NGTpNIFUSU6JRWK=
NCI-H1395 NXWxU4JDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXqdGtHUUN3ME2wMlE5Pjh{IN88US=> M2WyNHNCVkeHUh?=
JEG-3 M4rLUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\mSJdKSzVyPUCuNVg4ODVizszN M3r5[HNCVkeHUh?=
BCPAP NGfCXW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTVTWM2OD1yLkG4PFczKM7:TR?= M2TSdHNCVkeHUh?=
CAL-27 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;UVXFPUUN3ME2wMlE6ODJ{IN88US=> MXLTRW5ITVJ?
RD NFTxXGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMUmxNVMh|ryP MkPUV2FPT0WU
RVH-421 M2CyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMUmxNVYh|ryP NHrLRYVUSU6JRWK=
Capan-2 NIW0Z2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMUmyOVYh|ryP Mn7rV2FPT0WU
COLO-680N NIfYPZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG0ZopbUUN3ME2wMlE6OzZ2IN88US=> M{DSdnNCVkeHUh?=
NCI-H1650 NFTweoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKyeo9KSzVyPUCuNlAxPTdizszN NFH6ZnJUSU6JRWK=
SBC-5 NID4RnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL1TWM2OD1yLkKwNVE5KM7:TR?= MoXNV2FPT0WU
U031 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG5VZNKSzVyPUCuNlA2PDdizszN NIi3PZBUSU6JRWK=
S-117 NV;lT3V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjUTWM2OD1yLkKwOVY1KM7:TR?= MUDTRW5ITVJ?
DoTc2-4510 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[3fWh6UUN3ME2wMlIxPzZ7IN88US=> NHPXUXVUSU6JRWK=
AM-38 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3vTWM2OD1yLkKwPFQ5KM7:TR?= MnHDV2FPT0WU
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MFE-280 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nrcmlEPTB;MD6yNVI6QCEQvF2= MVPTRW5ITVJ?
TE-9 M{LhNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLLNZZKSzVyPUCuNlE4QDZizszN MmXtV2FPT0WU
C2BBe1 MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFS1[VJKSzVyPUCuNlIyQSEQvF2= M4jXTnNCVkeHUh?=
EoL-1-cell MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMkKyNFMh|ryP NUjWcI9FW0GQR1XS
G-361 NVy5NHk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jGOGlEPTB;MD6yNlY5OiEQvF2= NV[wU5p2W0GQR1XS
KYSE-270 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMkOwPFQh|ryP NX6zdFdjW0GQR1XS
TK10 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMkOxNVch|ryP NWHxS3lkW0GQR1XS
ML-2 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fuSmlEPTB;MD6yN|EyQSEQvF2= MonJV2FPT0WU
MHH-ES-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHkfHZuUUN3ME2wMlI{PjhzIN88US=> NIHI[YdUSU6JRWK=
BHY NIX3WpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7GeZZUUUN3ME2wMlI{PjlzIN88US=> MmfHV2FPT0WU
LS-513 M{Pybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjQfJZKSzVyPUCuNlM6PjFizszN NUfHOpFuW0GQR1XS
COLO-678 NXfK[WVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17acmlEPTB;MD6yOFA1PCEQvF2= M3z5WHNCVkeHUh?=
NCI-H747 M3fmSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPkTWM2OD1yLkK0NVY6KM7:TR?= M3PSRXNCVkeHUh?=
K5 MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3TTWM2OD1yLkK0N|gh|ryP NXP1Ooh4W0GQR1XS
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KINGS-1 MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzhNoNKSzVyPUCuNlQ2OjlizszN NX70bJdPW0GQR1XS
SCC-25 NXTGPVZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMkS1OlMh|ryP NEDsRoVUSU6JRWK=
CAPAN-1 NYizUG5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHLcYhKSzVyPUCuNlQ4QDNizszN NH;sRXZUSU6JRWK=
ESS-1 M3XMSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnwRo0{UUN3ME2wMlI1QDB3IN88US=> MVPTRW5ITVJ?
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NCI-H1048 NHS5WYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Tu[GlEPTB;MD6yPFk2PiEQvF2= MlvtV2FPT0WU
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COLO-684 Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXOenlTUUN3ME2wMlM1PTBzIN88US=> NYXI[YVJW0GQR1XS
NCI-H2405 M2XBVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjJTWM2OD1yLkO0OlMyKM7:TR?= NGXlU2NUSU6JRWK=
NCI-H2228 NXfje3pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnJfIFlUUN3ME2wMlM2OzV5IN88US=> NHzvVG9USU6JRWK=
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NCI-H1793 NXK3SndzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HqPWlEPTB;MD6zPFUyKM7:TR?= M3rpSnNCVkeHUh?=
HCE-T NIHGXVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nxN2lEPTB;MD6zPFYxOyEQvF2= MlHVV2FPT0WU
NCI-H520 NX;SfZNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTlbXRMUUN3ME2wMlM5PzB|IN88US=> MXTTRW5ITVJ?
HCC2157 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonlTWM2OD1yLkO4O|gyKM7:TR?= MULTRW5ITVJ?
EW-18 NHvVdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorlTWM2OD1yLkO4PVQyKM7:TR?= MY\TRW5ITVJ?
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PANC-10-05 NEjrdllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHWfJNKSzVyPUCuOFEyPyEQvF2= NFfrNWNUSU6JRWK=
NCI-H1703 M2G4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fJdGlEPTB;MD60NVQ1PiEQvF2= M2PvbnNCVkeHUh?=
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NCI-H2291 NH;3RlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X4O2lEPTB;MD60O|g6PiEQvF2= M{i3eHNCVkeHUh?=
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NCI-H2126 NIXEO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX72SphPUUN3ME2wMlU3QDF3IN88US=> M1nCUHNCVkeHUh?=
SNU-C2B NYLIToZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7lbpBFUUN3ME2wMlU4QTd5IN88US=> M1:1NnNCVkeHUh?=
DBTRG-05MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYixUmRQUUN3ME2wMlU5ODV|IN88US=> NUO2PGlOW0GQR1XS
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ACHN M37POWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\BOmlEPTB;MD62NFU3QSEQvF2= MkSxV2FPT0WU
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UACC-893 M1vxVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XSe2lEPTB;MD62N|Y5OSEQvF2= Mnj4V2FPT0WU
JVM-3 M{LXR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfDZ4RkUUN3ME2wMlY{QDB2IN88US=> MkTyV2FPT0WU
SF268 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\ZTWM2OD1yLk[0N|Q6KM7:TR?= M4\FfXNCVkeHUh?=
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RPMI-8226 MoPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT6cIc2UUN3ME2wMlY3OzJ|IN88US=> MXLTRW5ITVJ?
MKN28 NETTZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zjTWlEPTB;MD62OlYzPCEQvF2= M2DGU3NCVkeHUh?=
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BV-173 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\lWIpXUUN3ME2wMlY5Pjd7IN88US=> NYjXdZk4W0GQR1XS
NCI-H358 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwNki3NlYh|ryP MnzLV2FPT0WU
NCI-H1651 NIfMXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\QXGlEPTB;MD63JO69VQ>? NUH4cm81W0GQR1XS
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NCI-H2009 NWLRdHFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwOEWzNVEh|ryP NYrBTnJoW0GQR1XS
NCI-H522 Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf3WnRFUUN3ME2wMlg4Pzh|IN88US=> MkTVV2FPT0WU
Saos-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITrR4hKSzVyPUCuPFc5PzFizszN MVTTRW5ITVJ?
NB17 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwOEiwNlUh|ryP NFG5fJVUSU6JRWK=
D-392MG NHLD[HhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwOEmzOVYh|ryP MVzTRW5ITVJ?
SHP-77 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVi3[Gt[UUN3ME2wMlkxPDh3IN88US=> NH\Q[YpUSU6JRWK=
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SW948 M2Ppfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvyWXdKSzVyPUeuPVYxPDlizszN M1Kx[nNCVkeHUh?=
CAL-33 NGPIUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTdwOUm5N|gh|ryP MmnHV2FPT0WU
U-266 NWPjV4lQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPMS5J[UUN3ME24MlE2Pzd5IN88US=> MVHTRW5ITVJ?
CAL-72 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRThwMkCzNkDPxE1? MV\TRW5ITVJ?
SNU-423 NFTTb2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjZUGhKSzVyPUmuN|Y3PjZizszN NV3J[oNWW0GQR1XS
KG-1 NHS4bm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrqWFFKSzVyPUmuOVg1PTZizszN NXLLd2VzW0GQR1XS
HCC1395 NIHlRWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH6TWM2OD17LkmyN|UzKM7:TR?= MVLTRW5ITVJ?
BE-13 M37s[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHJOpEzUUN3ME2xNE45QDl{IN88US=> MomyV2FPT0WU
MKN7 NILGSmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDUW4hRUUN3ME2xNE46PzZ3IN88US=> MUfTRW5ITVJ?
697 M3j6Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLrTWM2OD1zMT6xOFczKM7:TR?= MUPTRW5ITVJ?
LU-135 NFfxfVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\NTWM2OD1zMT6yN|A4KM7:TR?= MlfLV2FPT0WU
ES7 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7DTWM2OD1zMT6zN|E{KM7:TR?= NV7t[oVpW0GQR1XS
SK-HEP-1 M3;lZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFzLke2OFYh|ryP MlnCV2FPT0WU
BEN NE\xe3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGCzO2lKSzVyPUGxMlg2OSEQvF2= NX60WWxJW0GQR1XS
NCI-H1770 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTF{LkGyOkDPxE1? MUPTRW5ITVJ?
SW13 M2rxTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnOdnBKSzVyPUGyMlE2PDFizszN M3rJWHNCVkeHUh?=
MZ1-PC M{LwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGwTWM2OD1zMj61OFUzKM7:TR?= M3\oSnNCVkeHUh?=
Mo-T M3Pv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWyS3JKSzVyPUGyMlc1OjFizszN M2DiUXNCVkeHUh?=
HLE NWe1RYc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnzbWhKSzVyPUGyMlgzOTVizszN NXjzW4R6W0GQR1XS
RCC10RGB MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED1fY9KSzVyPUGzMlY4OSEQvF2= NXHzelNyW0GQR1XS
COLO-320-HSR MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDPfnZNUUN3ME2xN{44OzhzIN88US=> NVfGeIJXW0GQR1XS
BHT-101 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP3bndPUUN3ME2xN{45OzR3IN88US=> M4DkSnNCVkeHUh?=
OCUB-M MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGKzUXBKSzVyPUG0MlE3ODJizszN M3;tWHNCVkeHUh?=
MEG-01 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGKycWpKSzVyPUG0MlM4ODhizszN M3Xxb3NCVkeHUh?=
RS4-11 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vyWWlEPTB;MUSuO|QzKM7:TR?= NEjhc2VUSU6JRWK=
MN-60 NUXmR|V2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF2Lke4PVQh|ryP M{L0OXNCVkeHUh?=
NCI-H1304 M2K1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXjfIVnUUN3ME2xOU4xPDJ3IN88US=> NWfMUJZuW0GQR1XS
Ramos-2G6-4C10 NGHFflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFe4Zm1KSzVyPUG1MlA2QDFizszN NUXObGNQW0GQR1XS
NCI-H2342 NUfYbW5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnywTWM2OD1zNT6yNFQ1KM7:TR?= MWHTRW5ITVJ?
LAN-6 NVvOUJFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvZXpp3UUN3ME2xOU41PDF2IN88US=> NHfofoVUSU6JRWK=
JVM-2 NF\6NZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF3LkW3OFgh|ryP MVvTRW5ITVJ?
P30-OHK NVLG[IxGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnPOFhKSzVyPUG2MlA3OTRizszN MmO2V2FPT0WU
C-33-A M3W5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXsNGtiUUN3ME2xOk43OjF2IN88US=> M3rnNHNCVkeHUh?=
RPMI-8866 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTF4Lki0PVYh|ryP MX3TRW5ITVJ?
NCI-H630 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTPTWM2OD1zNj64OVM4KM7:TR?= M4TzNXNCVkeHUh?=
KYSE-140 M2HSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTF5LkKwNlgh|ryP MnHaV2FPT0WU
T84 MlPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTmdIhKSzVyPUG4Mlg3QTVizszN NUHXeWVxW0GQR1XS
KU-19-19 MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHtTWM2OD1zOD65OlA5KM7:TR?= NGruZ5JUSU6JRWK=
BALL-1 MmLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF7LkOzPVkh|ryP NXTXXG5FW0GQR1XS
Calu-6 NXG2SI4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF7LkS5NkDPxE1? NXXLOWNqW0GQR1XS
EGI-1 M2P6fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTF7LkW5PEDPxE1? MXTTRW5ITVJ?
MFH-ino NH\STGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF7Lke0OVQh|ryP MX3TRW5ITVJ?
GB-1 NGnYdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe1OIMxUUN3ME2yNE4{PTN3IN88US=> NXnzd|NYW0GQR1XS
NCI-H1693 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJyLk[1NFUh|ryP NHjkbYhUSU6JRWK=
SW1116 M{D6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELFS3pKSzVyPUKwMlk{PjJizszN NWHlOnB4W0GQR1XS
H-EMC-SS MlL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorITWM2OD1{Mj6wOFUh|ryP M{TwWXNCVkeHUh?=
D-502MG MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGxTWM2OD1{Mj64NlYyKM7:TR?= NIL5RVVUSU6JRWK=
IA-LM NFj6R4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUCzTGNMUUN3ME2yN{4zPDl|IN88US=> M1f3XXNCVkeHUh?=
SW1463 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJ|Lke5JO69VQ>? NW\3U4NtW0GQR1XS
JAR NGr1UHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjHbWVXUUN3ME2yOE4{Ojl|IN88US=> NGroWYxUSU6JRWK=
HT MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJ2LkS3OVMh|ryP Mn;MV2FPT0WU
LCLC-103H M1fkcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzzdnVKSzVyPUK0Mlg1PDlizszN NF;ybW1USU6JRWK=
SNU-449 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj1U5kyUUN3ME2yOE45PzRzIN88US=> NWHTV2M1W0GQR1XS
KE-37 NGDHfHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XRb2lEPTB;MkWuNFkzQCEQvF2= M1fMPHNCVkeHUh?=
NCI-H1623 NFrSZYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJ5LkGzNFMh|ryP NIK2TIhUSU6JRWK=
MOLT-13 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUS2eWx5UUN3ME2yO{4{PTF4IN88US=> M1L3e3NCVkeHUh?=
COLO-741 M2XHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjNSJRKSzVyPUOxMlM{OzNizszN M1;sfHNCVkeHUh?=
NB6 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTN{LkK4O|Yh|ryP NVXjZppIW0GQR1XS
MOLT-16 NFvhW29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTN|LkCwOVUh|ryP NHjWcVZUSU6JRWK=
IST-MES1 NV7Gc5Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUe5PWQ{UUN3ME2zOE4xPTRzIN88US=> MVzTRW5ITVJ?
A4-Fuk MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf0OFgyUUN3ME2zOU4xPjZizszN NYPOblZIW0GQR1XS
CAL-85-1 NYLMe|dmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv6bZhUUUN3ME2zOU4zQDF5IN88US=> NG\XV3lUSU6JRWK=
CCRF-CEM MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C2VWlEPTB;M{euNVU{PiEQvF2= MkHxV2FPT0WU
HAL-01 M2DYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvhTWM2OD1|OD60PFg6KM7:TR?= NWC3TYNQW0GQR1XS
HEL MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjlc2lKSzVyPUSzMlM1ODlizszN MYTTRW5ITVJ?
EW-1 NFLJcnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XLNGlEPTB;NEOuOFc3QCEQvF2= MojYV2FPT0WU
MDA-MB-231 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3rb3V7UUN3ME20OU4yOTl7IN88US=> NVjkZpBoW0GQR1XS
ABC-1 M1PIXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTR4Lki1N|gh|ryP M{X5V3NCVkeHUh?=
NCI-H446 NWHtPYx5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mly3TWM2OD12OD61NFU5KM7:TR?= MX\TRW5ITVJ?
MHH-PREB-1 M2fXPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHlSGNKSzVyPUS5MlYxODdizszN MUDTRW5ITVJ?
DOHH-2 M2XBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3oTWM2OD12OT62OlU3KM7:TR?= MoPZV2FPT0WU
GCT MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULwb3BlUUN3ME20PU43QTd4IN88US=> Mn\tV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]
臨床試験 A Phase II study of 17-AAG in patients with relapsed/refractory CD30 plus anaplastic large cell lymphoma (ALCL) relapsed/refractory mantle cell lymphoma (MCL) and relapsed/refractory classical Hodgkin's lymphoma (HL) has been completed.
特集 Displays very low toxicity toward normal cells.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Hsp90 binding assays Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.

細胞アッセイ: [1]

細胞株 BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 5 days
実験の流れ Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.

動物実験: [2]

動物モデル Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
製剤 Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
投薬量 ~50 mg/kg
投与方法 Injection i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download 17-AAG (Tanespimycin) SDF
分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管 2年-20℃
6月-80℃in solvent
別名 CP127374,NSC-330507, KOS 953
溶解度 (25°C) * In vitro DMSO 100 mg/mL (170.73 mM)
エタノール 5 mg/mL (8.53 mM)
<1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 17-demethoxy-17-(2-propenylamino)- [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

カスタマーフィードバック (7)


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Source , , PNAS, 2011, 108: 7535-40. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines H3122 & H3122 CR cells
Concentrations 10 nM
Incubation Time 72 h
Results As shown in Fig. A, 17-AAG potently suppressed cell growth in both parental H3122 and H3122 CR cells. However, in contrast to NVP-TAE684 and AP26113, 17-AAG also inhibited the viability of SKBR3 and BT474 cell lines. 17-AAG treatment decreased both p-ALK 眏Ỵ眐㠞眎膉癠 皐﷘ř᐀ŔřĀ 㺣癞帉癞Ѐ瑖兽ﱔᆊࣿřĀࣾ彿兾奋兾巫兾婶ࣿ橢ࣿ彿兾

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Rating
Source Oncotarget, 2014, 5, 4269-82. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines Ls-174T, HCT116, Caco2, Hke3 cells
Concentrations 0.5, 2 uM
Incubation Time 24 h
Results Colon cancer cells harboring WT or MT K-Ras were treated with 17-AAG and effects on the Ras expression were analyzed by WB. Results in Figure showed that incubation with 17-AAG only down-regulates K-Ras in K-Ras MT cells but decreases Raf-1 {an established Hsp90 client} in all cell lines. The result, for the first time, demonstrated that both transfected and endogenous MT K-Ras is an Hsp90 client protein.

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Rating
Source Oncotarget, 2015, 51: S659-S660. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines MOLT-4 & RS4;11 cells
Concentrations
Incubation Time 22 h
Results In both MOLT-4 and RS4;11 cells, the combined treatment inhibited the interactions between Hsp90 and BIP/Grp78 more effectively than CX-4945 single treatment and to the same extent as tanespimycin (17-AAG).

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Rating
Source Mol Cell Biol, 2013, 33(12), 2375-87. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines NIH 3T3 cells
Concentrations 25, 50 uM
Incubation Time 4 h
Results 17-AAG and SNX-2112, both of which induce the UPR by targeting the chaperone HSP90, decreased mSmoM2 protein levels (lanes 2 to 5 compared to lane 1), further supporting the sensitivity of active Smo mutants to UPR induction.

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Rating
Source J Biol Chem, 2012, 287, 44109-20. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines Dopaminergic Neuronal Cell lines
Concentrations 10-20uM
Incubation Time
Results As expected, both complex IV activity and Hsp60 levels exhibited a dose-dependent decrease in response to treatment with 17-AAG (Fig. 4A). However, 17-AAG treatment did not alter levels of Hsp90 and LRPPRC levels

Click to enlarge
Rating
Source Mol Cancer, 2014, 13, 150. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines SKBR3 cells
Concentrations 1, 2 uM
Incubation Time 24 h
Results Hsp90 and Cdc37 protein levels showed no distinct change according to a drug concentration gradient, whereas Hsp70, a marker of Hsp90 inhibition, the protein level was greatly induced by treatment with 17AAG or FW-04-806.

Click to enlarge
Rating
Source Age, 2013, 35, 549-62. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines HFSN1 cells
Concentrations 0.1/0.5uM
Incubation Time 24 h
Results Figure 2c shows that the decrease in the level of Hsp90 after treatment with 0.5 μM of 17-AAG was accompanied by a decrease in the level of both the survivin and phospho-survivin proteins.

文献中の引用 (19)

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    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    ノーカット二量体Hsp90またはN末端領域Hsp90と結合している間、Geldanamycinは1.2のμMまたは0.78のμMによるKdによる天然既存のHsp90阻害剤です。

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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