17-AAG (Tanespimycin) 化学構造
分子量: 585.69

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製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 17-AAG (Tanespimycin)は、5nMのIC50による強力な熱ショックタンパク質90(Hsp90)阻害剤です。
ターゲット HSP90
IC50 5 nM [1]
In vitro試験 17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A549 Ml7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\vbGlEPTB;MD6wNFA{ODNizszN MUHTRW5ITVJ?
IST-MEL1 NHnod|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonuTWM2OD1yLkCwNFQxPyEQvF2= NGLmV3dUSU6JRWK=
NCI-SNU-1 NYPhW2txT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofOTWM2OD1yLkCwNlA4KM7:TR?= NGjXZoJUSU6JRWK=
FADU Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jVWmlEPTB;MD6wNFIxQSEQvF2= NFfqXZBUSU6JRWK=
C32 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIq5WZBKSzVyPUCuNFA{ODRizszN M{\PUHNCVkeHUh?=
D-566MG M2X6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L5cWlEPTB;MD6wNFM6KM7:TR?= MlzXV2FPT0WU
LXF-289 MlW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rlcWlEPTB;MD6wNFQyQSEQvF2= MknXV2FPT0WU
HGC-27 Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3L3Z2lEPTB;MD6wNFUyKM7:TR?= NVX6[FBvW0GQR1XS
RPMI-7951 NV7lRZFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr2TY5HUUN3ME2wMlAxPzF5IN88US=> MkjuV2FPT0WU
HSC-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TUbGlEPTB;MD6wNFkzQSEQvF2= NGq3SY1USU6JRWK=
MIA-PaCa-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvGUHlKSzVyPUCuNFExODlizszN MX7TRW5ITVJ?
KS-1 M{HVVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HySmlEPTB;MD6wNVM2PSEQvF2= MknYV2FPT0WU
CAL-51 M4n1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDLZ3RKSzVyPUCuNFE1ODVizszN NEDxNZlUSU6JRWK=
MDA-MB-361 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXvU2pKSzVyPUCuNFE1QTVizszN NHv4elhUSU6JRWK=
TI-73 MorxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEG3PVYh|ryP NGLKVZRUSU6JRWK=
AGS MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMEG5N|gh|ryP MUPTRW5ITVJ?
NCI-H460 M1vrd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfrN4tNUUN3ME2wMlAyQTd2IN88US=> MXLTRW5ITVJ?
A204 NEf6bopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX5bIlKSzVyPUCuNFIzPDlizszN NXTUfIdbW0GQR1XS
CHL-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLETWM2OD1yLkCyNlUyKM7:TR?= MlfWV2FPT0WU
DU-4475 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\VcWlEPTB;MD6wNlI3OSEQvF2= MV7TRW5ITVJ?
CGTH-W-1 NYLGRXZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37hTWlEPTB;MD6wNlM1QSEQvF2= NGHh[G1USU6JRWK=
HCC2218 M3vnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEK0PVQh|ryP MkjKV2FPT0WU
A2780 M1Hhb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEK1N|Eh|ryP NE\JOFZUSU6JRWK=
NCI-H720 M4jBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnUTFZ7UUN3ME2wMlAzPTR4IN88US=> MWLTRW5ITVJ?
NCI-N87 NGPvc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHNTWM2OD1yLkCyOVk{KM7:TR?= M4KxWnNCVkeHUh?=
CHP-212 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHlTWM2OD1yLkCyOlI5KM7:TR?= NH\I[pdUSU6JRWK=
NCI-H23 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\Ke2lnUUN3ME2wMlAzPjZ3IN88US=> MWDTRW5ITVJ?
D-263MG MlnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjTTZFGUUN3ME2wMlAzPzh4IN88US=> NGTsWlNUSU6JRWK=
ME-180 NGXvdm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXP6TZRtUUN3ME2wMlAzQDlzIN88US=> NGexclJUSU6JRWK=
SW982 NHzVUYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnz[m1GUUN3ME2wMlAzQTl7IN88US=> MmfTV2FPT0WU
OE19 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLYUFlsUUN3ME2wMlA{ODd5IN88US=> NH\a[WdUSU6JRWK=
SK-LU-1 M4fkZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DaVmlEPTB;MD6wN|A5OiEQvF2= NIXCSIRUSU6JRWK=
H4 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMEOwPUDPxE1? M{PkU3NCVkeHUh?=
HT-144 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEOwPVMh|ryP MYXTRW5ITVJ?
SK-UT-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHsR2lqUUN3ME2wMlA{OTd6IN88US=> Mlu3V2FPT0WU
D-336MG M1rGN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEOzNFkh|ryP M3Kyd3NCVkeHUh?=
MDA-MB-175-VII NWDkZVB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEOzOVQh|ryP NYn5TIRRW0GQR1XS
GAMG NIDk[lJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPpcHd3UUN3ME2wMlA{PDN3IN88US=> NXS5T3cyW0GQR1XS
CP50-MEL-B M1L4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fMfGlEPTB;MD6wN|Q2KM7:TR?= MXnTRW5ITVJ?
OVCAR-5 M13heWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXSV|BUUUN3ME2wMlA{PDhizszN NVXkfnBzW0GQR1XS
SK-MES-1 NWi3WHk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMEO2NFYh|ryP NI\yUGxUSU6JRWK=
VM-CUB-1 M{\GSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\aTWM2OD1yLkCzOlU4KM7:TR?= MlPTV2FPT0WU
WM-115 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Lq[GlEPTB;MD6wN|c3OiEQvF2= MYrTRW5ITVJ?
DSH1 M{P3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PMXmlEPTB;MD6wN|gxPyEQvF2= MkDCV2FPT0WU
Becker NH\CdZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Pz[WlEPTB;MD6wN|g5PSEQvF2= NX[1VZU1W0GQR1XS
SW962 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMEO5OFUh|ryP M2CwVHNCVkeHUh?=
TYK-nu NW\0fJdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXwU5lWUUN3ME2wMlA{QTh3IN88US=> M1LNbnNCVkeHUh?=
HO-1-N-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[1TWM2OD1yLkC0NFIyKM7:TR?= M3ziNHNCVkeHUh?=
T98G Mnm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzOTWM2OD1yLkC0NVA{KM7:TR?= NYPrfoUyW0GQR1XS
ACN MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH76XHlKSzVyPUCuNFQyPjJizszN MYfTRW5ITVJ?
SW780 NFrEUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofGTWM2OD1yLkC0NlA{KM7:TR?= Mk\6V2FPT0WU
Detroit562 NIL6U3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLhZ2RKSzVyPUCuNFQzOzlizszN NX:zcJlRW0GQR1XS
BB49-HNC MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe4XYg{UUN3ME2wMlA1OjR|IN88US=> MnuxV2FPT0WU
HN NWfyTYFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;5dmlEPTB;MD6wOFI4OiEQvF2= MX;TRW5ITVJ?
H9 M2nRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnntTWM2OD1yLkC0N|cyKM7:TR?= MXHTRW5ITVJ?
VA-ES-BJ M2jQS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMES0OFch|ryP MmnXV2FPT0WU
MEL-JUSO NGHnOmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnBTWM2OD1yLkC0OFc2KM7:TR?= MW\TRW5ITVJ?
BT-474 M3r5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTsOlFmUUN3ME2wMlA1PSEQvF2= NWnv[JVNW0GQR1XS
CaR-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13Ud2lEPTB;MD6wOFU1QSEQvF2= NHjlNoZUSU6JRWK=
PSN1 MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;wVGdKSzVyPUCuNFQ3ODNizszN MUPTRW5ITVJ?
KYSE-510 NWXQZ2FmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMES2OFkh|ryP MX3TRW5ITVJ?
KP-4 NFn2cmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMES3OVMh|ryP MVrTRW5ITVJ?
KYSE-410 MonRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DjS2lEPTB;MD6wOFc4OiEQvF2= M3LnOnNCVkeHUh?=
G-402 NF6zTJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{D5W2lEPTB;MD6wOFc5QSEQvF2= MUPTRW5ITVJ?
DOK NIDBfnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7GZ41lUUN3ME2wMlA1QTB{IN88US=> MkDRV2FPT0WU
COR-L88 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPYOXB1UUN3ME2wMlA1QTF{IN88US=> MULTRW5ITVJ?
SKG-IIIa NIHj[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nXemlEPTB;MD6wOFk5PiEQvF2= NEW1VXJUSU6JRWK=
AN3-CA Mo\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjxTWM2OD1yLkC1JO69VQ>? MU\TRW5ITVJ?
SW48 M1zQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT1O5dKSzVyPUCuNFUxOzlizszN M4\YdXNCVkeHUh?=
YKG-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnvPHRCUUN3ME2wMlA2ODdzIN88US=> M1OwWHNCVkeHUh?=
KYSE-150 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEWyN|Uh|ryP NEXGUmtUSU6JRWK=
HuO-3N1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTXTWM2OD1yLkC1NlM4KM7:TR?= MUTTRW5ITVJ?
LB1047-RCC NFXISlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe5TWM2OD1yLkC1Nlk3KM7:TR?= M2rxU3NCVkeHUh?=
NCI-H2030 NFjwR3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrKNG5KSzVyPUCuNFU1OTRizszN NEHTSotUSU6JRWK=
YH-13 M4Ppemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDWflg1UUN3ME2wMlA2PzJ{IN88US=> MmTCV2FPT0WU
5637 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLmc|RKSzVyPUCuNFU4PCEQvF2= M3f4O3NCVkeHUh?=
LOXIMVI NXLVRXpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEW4O|Ih|ryP MnvrV2FPT0WU
GT3TKB M1Wx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEW5OFIh|ryP MVvTRW5ITVJ?
TCCSUP MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEW5OlQh|ryP Mn2yV2FPT0WU
EPLC-272H NX64UpdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPM[WFKSzVyPUCuNFYzODVizszN NVm1OIVIW0GQR1XS
LU-99A NHLJVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwME[yN|ch|ryP NWPBdo84W0GQR1XS
NCI-H1755 NFz2dZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjEV3ZKSzVyPUCuNFY{PDFizszN NXvLNZpHW0GQR1XS
KM12 M3HrRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nUTGlEPTB;MD6wOlM1QCEQvF2= M3:yWHNCVkeHUh?=
SF295 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n0OGlEPTB;MD6wOlQ2OiEQvF2= MkPyV2FPT0WU
MZ2-MEL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnYXIRKSzVyPUCuNFY2PTNizszN NH3m[XNUSU6JRWK=
HEC-1 NUHXNmhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnhTWM2OD1yLkC2OVg5KM7:TR?= MU\TRW5ITVJ?
SW684 NFHWN5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzVTXZKSzVyPUCuNFY2QTFizszN NIDVSnRUSU6JRWK=
SF539 NF\MWplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTtcVdKSzVyPUCuNFY3QDFizszN MUHTRW5ITVJ?
GMS-10 NHriVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX1N2pKSzVyPUCuNFY3QTlizszN M133RnNCVkeHUh?=
MV-4-11 NW\ZbpVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX1WmEzUUN3ME2wMlA3QDB|IN88US=> MlzqV2FPT0WU
HT-29 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPzTWM2OD1yLkC2PVE6KM7:TR?= Mn;mV2FPT0WU
23132-87 NUPKRYVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwME[5OUDPxE1? MVXTRW5ITVJ?
SW620 MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEewNlYh|ryP NYfPOYtNW0GQR1XS
HCC1806 M{jGdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEexN|Eh|ryP M{jmcHNCVkeHUh?=
Hs-578-T NWTVbG1ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[1PGlEPTB;MD6wO|IxQCEQvF2= NGToZVVUSU6JRWK=
A2058 NHrPU5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEeyNlgh|ryP M4TjPXNCVkeHUh?=
MEL-HO M4rQ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv5TWM2OD1yLkC3NlU2KM7:TR?= NIHkUFJUSU6JRWK=
HCC2998 NVHQUldPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjkb2V[UUN3ME2wMlA4OzR5IN88US=> MV;TRW5ITVJ?
HuO9 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorUTWM2OD1yLkC3OVg6KM7:TR?= M4W2U3NCVkeHUh?=
CAL-39 NYLGb3dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\U[WlEPTB;MD6wO|c3PiEQvF2= NGDCWGhUSU6JRWK=
M14 MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL6d2J7UUN3ME2wMlA4QTF|IN88US=> M1zuRXNCVkeHUh?=
BFTC-909 M2XPTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDrTWM2OD1yLkC3PVY6KM7:TR?= M4G1d3NCVkeHUh?=
TE-11 M2rTcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\uTWM2OD1yLkC3PVk3KM7:TR?= Ml;1V2FPT0WU
TGBC1TKB MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qybGlEPTB;MD6wPFA1OyEQvF2= NVPsTnM2W0GQR1XS
L-363 M3rNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTzTWM2OD1yLkC4NlA3KM7:TR?= MWfTRW5ITVJ?
A431 NY\tR5lOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm5U|VKSzVyPUCuNFgzOSEQvF2= NH7Ne4FUSU6JRWK=
MKN45 Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH4TWM2OD1yLkC4NlE6KM7:TR?= M1XZcnNCVkeHUh?=
HT-1080 M{fUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPrTWM2OD1yLkC4OFM6KM7:TR?= M{XvW3NCVkeHUh?=
OVCAR-8 MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXlN3BKSzVyPUCuNFg3OjJizszN MUDTRW5ITVJ?
LCLC-97TM1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\VUY9KSzVyPUCuNFg4OjhizszN M4HuNXNCVkeHUh?=
M059J MknXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMEmwNlch|ryP NFHkd4VUSU6JRWK=
SK-MEL-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TWe2lEPTB;MD6wPVA3KM7:TR?= M1vkfHNCVkeHUh?=
TE-1 M2HCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrBXYVKSzVyPUCuNFkzODRizszN NXr3[IRsW0GQR1XS
KYSE-180 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvOVIFKSzVyPUCuNFkzPjJizszN MUnTRW5ITVJ?
D-247MG NEnmbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEm0OVUh|ryP Ml3EV2FPT0WU
8-MG-BA M2r4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonKTWM2OD1yLkC5OFczKM7:TR?= NFjQd2RUSU6JRWK=
NCI-H1792 NYjk[pR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrsTWM2OD1yLkC5OlE5KM7:TR?= NFLh[XZUSU6JRWK=
MCF7 M3rMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjKOYpoUUN3ME2wMlA6Pjd5IN88US=> M3:5bXNCVkeHUh?=
NCI-H2122 M4HFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP0TWM2OD1yLkC5O|Q2KM7:TR?= NFzLe5VUSU6JRWK=
EFO-27 MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMEm5PVch|ryP NVT6UJpRW0GQR1XS
LB2241-RCC MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;xbY5uUUN3ME2wMlExODV2IN88US=> MV\TRW5ITVJ?
SN12C MlPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:1TWM2OD1yLkGwNVA4KM7:TR?= MUjTRW5ITVJ?
A498 NF:xRo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX5TWM2OD1yLkGwNVgh|ryP NV7CeGRuW0GQR1XS
PANC-03-27 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\YO4JKSzVyPUCuNVAzQDZizszN M3\BSHNCVkeHUh?=
NCI-H1581 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMUCyPUDPxE1? NGPQcoRUSU6JRWK=
U-87-MG MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PtXGlEPTB;MD6xNFMxPyEQvF2= M2nVbnNCVkeHUh?=
G-401 NHPLTZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHRcYlKSzVyPUCuNVA{PTNizszN MYPTRW5ITVJ?
SiHa MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fN[mlEPTB;MD6xNFQ5PiEQvF2= NGTxXpVUSU6JRWK=
U251 NXrzd2ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnftTWM2OD1yLkGwOVI2KM7:TR?= MULTRW5ITVJ?
MMAC-SF M3T3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXlRpRJUUN3ME2wMlExPTNzIN88US=> M3LCdXNCVkeHUh?=
BB65-RCC NInZeI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fqNmlEPTB;MD6xNFU2PCEQvF2= M1vtV3NCVkeHUh?=
NKM-1 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DhR2lEPTB;MD6xNFY3PiEQvF2= NEC5XnlUSU6JRWK=
HD-MY-Z MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki3TWM2OD1yLkGwPFc{KM7:TR?= M3z5[HNCVkeHUh?=
TGBC11TKB NWG4Rm1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMUC5NFMh|ryP NHPPcFdUSU6JRWK=
COLO-679 NX7SfGt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\5OppKSzVyPUCuNVEzOTFizszN MXHTRW5ITVJ?
TE-8 NIDp[XJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMUGyOlQh|ryP MkDFV2FPT0WU
SK-MEL-28 NYXZR5oyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrZcZRIUUN3ME2wMlEyOzJzIN88US=> NF7CRZFUSU6JRWK=
SH-4 NH3zfGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;iemlEPTB;MD6xNVM2PiEQvF2= NF;NTIdUSU6JRWK=
KALS-1 NGrCUmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3CSJlKUUN3ME2wMlEyOzl|IN88US=> MX\TRW5ITVJ?
RKO Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHrSZdVUUN3ME2wMlEyPzZ2IN88US=> NHuycllUSU6JRWK=
OMC-1 M{Xje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMUG3PVch|ryP NVf6TGJQW0GQR1XS
BT-549 M3rmNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLxOFhKSzVyPUCuNVE4QTlizszN M{DOcXNCVkeHUh?=
NCI-H28 M{LEOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3XTWM2OD1yLkGxPFE4KM7:TR?= NUD1XY5sW0GQR1XS
RXF393 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zSemlEPTB;MD6xNVk5OiEQvF2= M17VfnNCVkeHUh?=
COLO-829 NHnCe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\5TWM2OD1yLkGyNFA2KM7:TR?= Mn3UV2FPT0WU
HMV-II NYfGc5ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv2dVZKSzVyPUCuNVIxOiEQvF2= M{LWTnNCVkeHUh?=
SW1990 NE\ZUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PlO2lEPTB;MD6xNlE2PyEQvF2= MVLTRW5ITVJ?
NCI-H1437 M1;KWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\PWWlEPTB;MD6xNlE2PyEQvF2= NUfad|dJW0GQR1XS
SNB75 NWfFUoM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHu5WGpKSzVyPUCuNVIyPjlizszN NEf2V2NUSU6JRWK=
EW-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzrTWM2OD1yLkGyOlYyKM7:TR?= M1j1cXNCVkeHUh?=
SAS NYXqToMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfYSWRKSzVyPUCuNVI3QSEQvF2= M2q4fXNCVkeHUh?=
NCI-H1666 NYSzPHlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfFTWM2OD1yLkGyO|c1KM7:TR?= M1\SNnNCVkeHUh?=
A375 Mm\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDTbHJSUUN3ME2wMlEzPzd6IN88US=> MYnTRW5ITVJ?
CAMA-1 MlzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PVV2lEPTB;MD6xNlkzPCEQvF2= MlTRV2FPT0WU
HuP-T4 NUnITo57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMUK5OFMh|ryP MoPEV2FPT0WU
NCI-H292 Mn;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHGT5RKSzVyPUCuNVMyOSEQvF2= MWTTRW5ITVJ?
PC-14 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmX0TWM2OD1yLkGzNlEyKM7:TR?= M3foUXNCVkeHUh?=
BPH-1 MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL1bWs4UUN3ME2wMlE{PDFizszN Ml\YV2FPT0WU
GAK NInxUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnUeoM{UUN3ME2wMlE{PTZ5IN88US=> NUPVbZY4W0GQR1XS
VMRC-RCZ M2\Xcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HTN2lEPTB;MD6xN|c3OiEQvF2= NEe3NnJUSU6JRWK=
SK-MEL-24 Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLW[3QxUUN3ME2wMlE{QDdizszN NWnGWIVLW0GQR1XS
LB831-BLC NWe1SVd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMUO4PFMh|ryP MWXTRW5ITVJ?
NCI-H2452 M4rCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMUO5OVYh|ryP NELscYFUSU6JRWK=
RT-112 NIfDUWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rhSmlEPTB;MD6xOFA{PSEQvF2= M2Pad3NCVkeHUh?=
GP5d NY\kOVNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;SXmlEPTB;MD6xOFExPCEQvF2= M{PjXHNCVkeHUh?=
LC-2-ad MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMUSxNlEh|ryP M3HqTXNCVkeHUh?=
MPP-89 MorZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnsUoxZUUN3ME2wMlE1OTJ3IN88US=> NF\KNplUSU6JRWK=
NUGC-3 M3vvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;YfVBKSzVyPUCuNVQ1PzhizszN MoXaV2FPT0WU
GI-1 NGC0elNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMUS1OVgh|ryP Ml7hV2FPT0WU
HCC1419 NXrLe|EzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LNO2lEPTB;MD6xOFU4PiEQvF2= Moi4V2FPT0WU
SW1573 M{PjSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\YNZVwUUN3ME2wMlE1PzV6IN88US=> NWDzR4xHW0GQR1XS
NCI-H2347 M4S2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;nSWpKSzVyPUCuNVQ5OzlizszN NVm5N2Z6W0GQR1XS
Mewo NYi4b2FIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITkUYhKSzVyPUCuNVQ5QDlizszN M37kWnNCVkeHUh?=
639-V MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHrTWM2OD1yLkG1NFE{KM7:TR?= M{XienNCVkeHUh?=
AsPC-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH1U|FKSzVyPUCuNVUzOjVizszN Mk\XV2FPT0WU
NCI-H1648 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTCTWM2OD1yLkG1NlMzKM7:TR?= NGLoUI5USU6JRWK=
786-0 M{HqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvpbHFNUUN3ME2wMlE2OzhzIN88US=> NFPoT3NUSU6JRWK=
ETK-1 M{DKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;sTWM2OD1yLkG1PUDPxE1? NYjUW3BYW0GQR1XS
BxPC-3 NUnoRpNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnYdZpMUUN3ME2wMlE2QTZ4IN88US=> MV3TRW5ITVJ?
CAL-62 M1XpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXeyN3FGUUN3ME2wMlE3OTZ7IN88US=> NHuxbW9USU6JRWK=
HCC1937 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMU[yO|Uh|ryP MVTTRW5ITVJ?
NCI-H1299 NVvNfIhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzw[5ZKSzVyPUCuNVYzQDVizszN MkTzV2FPT0WU
SW1088 NF\neFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37PVGlEPTB;MD6xOlQyOyEQvF2= NFrpVpVUSU6JRWK=
FTC-133 NY\ZcJVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LGOmlEPTB;MD6xOlU1KM7:TR?= MVjTRW5ITVJ?
OC-314 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnLU|lKSzVyPUCuNVY3QSEQvF2= NH3TfYdUSU6JRWK=
SCC-9 M4\OVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[1UGlEPTB;MD6xOlcyPiEQvF2= M2OxOHNCVkeHUh?=
HT-1376 NV;vV2FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TmRmlEPTB;MD6xOlk{PiEQvF2= M2\wUHNCVkeHUh?=
U-2-OS MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzBWHpIUUN3ME2wMlE4OTd|IN88US=> MnvPV2FPT0WU
COLO-824 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW2XXZHUUN3ME2wMlE4Ojl2IN88US=> NWP5[IdZW0GQR1XS
BB30-HNC NGTDSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DTfWlEPTB;MD6xO|M{KM7:TR?= MmO3V2FPT0WU
NCI-H2087 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jKZWlEPTB;MD6xO|M3QCEQvF2= M3y2bnNCVkeHUh?=
NCI-H2170 NH;2W4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMUe1N|Yh|ryP M1u3cnNCVkeHUh?=
SK-OV-3 M2\uWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnYTWM2OD1yLkG3OVcyKM7:TR?= MlvFV2FPT0WU
MZ7-mel Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnEeGZKSzVyPUCuNVc3PDlizszN NWnOOolNW0GQR1XS
NCI-H650 NHToSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi4VWtJUUN3ME2wMlE4Pjh{IN88US=> M1H5SHNCVkeHUh?=
KOSC-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX4V2xKSzVyPUCuNVc4OzRizszN M1;wT3NCVkeHUh?=
SCC-4 MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17ISGlEPTB;MD6xO|c4PyEQvF2= NXzGO2Z{W0GQR1XS
MDA-MB-157 Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMUiwPFIh|ryP NFvmN29USU6JRWK=
KYSE-520 NEL0eVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLWR|FKSzVyPUCuNVgzKM7:TR?= MXTTRW5ITVJ?
LK-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMUizNFMh|ryP MUHTRW5ITVJ?
KNS-81-FD MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPHNXQzUUN3ME2wMlE5Ozl2IN88US=> MlvOV2FPT0WU
IGROV-1 NYPINIhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMUi0OFMh|ryP NUPKZWkzW0GQR1XS
DEL NFfXWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Tz[mlEPTB;MD6xPFQ2KM7:TR?= MWfTRW5ITVJ?
NCI-H1395 M2\6fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LKcGlEPTB;MD6xPFY5OiEQvF2= MlzlV2FPT0WU
JEG-3 NVnBcnhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrVTWM2OD1yLkG4O|A2KM7:TR?= NYHMXY01W0GQR1XS
BCPAP MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDaTYExUUN3ME2wMlE5QDd{IN88US=> MlviV2FPT0WU
CAL-27 M1X5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMUmwNlIh|ryP NV3OO5FLW0GQR1XS
RD Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HscWlEPTB;MD6xPVEyOyEQvF2= MoWxV2FPT0WU
RVH-421 NHXHbldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMUmxNVYh|ryP NV7KRYMxW0GQR1XS
Capan-2 MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjRO2ZjUUN3ME2wMlE6OjV4IN88US=> NFG2NnNUSU6JRWK=
COLO-680N M3z6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDHTGJKSzVyPUCuNVk{PjRizszN M3nGdHNCVkeHUh?=
NCI-H1650 M4XUXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\vS49TUUN3ME2wMlIxODV5IN88US=> MmTQV2FPT0WU
SBC-5 NGXPdIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXaVHlTUUN3ME2wMlIxOTF6IN88US=> NUfMSI5ZW0GQR1XS
U031 M4[1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMkC1OFch|ryP M{XOUnNCVkeHUh?=
S-117 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLMTWM2OD1yLkKwOVY1KM7:TR?= MmnjV2FPT0WU
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AM-38 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMkC4OFgh|ryP M4DabXNCVkeHUh?=
A172 NVnidXdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3wN2NKSzVyPUCuNlExOjJizszN MVLTRW5ITVJ?
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769-P MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMkGyPEDPxE1? M3\2XXNCVkeHUh?=
MFE-280 NGjMOHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[4TWM2OD1yLkKxNlk5KM7:TR?= M4DTSHNCVkeHUh?=
TE-9 NGnp[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\XW2hVUUN3ME2wMlIyPzh4IN88US=> MlXvV2FPT0WU
C2BBe1 Mme1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvCTWM2OD1yLkKyNVkh|ryP NYjFeZM6W0GQR1XS
EoL-1-cell M2DlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17mU2lEPTB;MD6yNlIxOyEQvF2= M3fV[XNCVkeHUh?=
G-361 MlLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnKwTWM2OD1yLkKyOlgzKM7:TR?= NXjV[Jh3W0GQR1XS
KYSE-270 NYPld5lFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\5WnJKSzVyPUCuNlMxQDRizszN NFP5XWlUSU6JRWK=
TK10 MkiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XpUGlEPTB;MD6yN|EyPyEQvF2= NGjHNVJUSU6JRWK=
ML-2 NH70XnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHP[IxKSzVyPUCuNlMyOTlizszN NELaXVVUSU6JRWK=
MHH-ES-1 M2LUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPBZmlKSzVyPUCuNlM3QDFizszN MluwV2FPT0WU
BHY MkjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D0fmlEPTB;MD6yN|Y6OSEQvF2= NWS5O3NEW0GQR1XS
LS-513 NXfSTJhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP6WlJTUUN3ME2wMlI{QTZzIN88US=> Mo[1V2FPT0WU
COLO-678 NVPtUoxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnQbHJKSzVyPUCuNlQxPDRizszN Ml:zV2FPT0WU
NCI-H747 M1\aTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HtT2lEPTB;MD6yOFE3QSEQvF2= M2i2UHNCVkeHUh?=
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OS-RC-2 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlX4TWM2OD1yLkK0OVA6KM7:TR?= M{jp[XNCVkeHUh?=
KINGS-1 MnrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP3SWw3UUN3ME2wMlI1PTJ7IN88US=> NVj5S5BkW0GQR1XS
SCC-25 MlLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXHTWM2OD1yLkK0OVY{KM7:TR?= NFvvdFRUSU6JRWK=
CAPAN-1 NXjHSnZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDpcFZIUUN3ME2wMlI1Pzh|IN88US=> MVrTRW5ITVJ?
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P12-ICHIKAWA NHyxPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTdwNEW1NlMh|ryP MVTTRW5ITVJ?
NCI-H82 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTdwNEW3NFEh|ryP MWrTRW5ITVJ?
NCI-H1993 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37QbWlEPTB;Nz64N|A3OyEQvF2= NXX2eVVNW0GQR1XS
RH-1 MmXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETWSGdKSzVyPUeuPFUzPDRizszN MmXaV2FPT0WU
SW948 M1W2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjX[JRKSzVyPUeuPVYxPDlizszN NIfr[mNUSU6JRWK=
CAL-33 NY\6SGl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HaemlEPTB;Nz65PVk{QCEQvF2= NI\hOpRUSU6JRWK=
U-266 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\GOGlEPTB;OD6xOVc4PyEQvF2= MlH5V2FPT0WU
CAL-72 NYfseZVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3ONIdKSzVyPUiuNlA{OiEQvF2= M2G2d3NCVkeHUh?=
SNU-423 NXnBeGdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrNS|h6UUN3ME25MlM3PjZ4IN88US=> NF;Xb5RUSU6JRWK=
KG-1 NUTYPFZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDQdnZ2UUN3ME25MlU5PDV4IN88US=> MoLJV2FPT0WU
HCC1395 NGLLSmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTlwOUKzOVIh|ryP MkK4V2FPT0WU
BE-13 NWP4fnU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TxdWlEPTB;MUCuPFg6OiEQvF2= M1izbXNCVkeHUh?=
MKN7 M3Tscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTjW5ZJUUN3ME2xNE46PzZ3IN88US=> NXrVNHRmW0GQR1XS
697 NHn3VoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTFzLkG0O|Ih|ryP MWfTRW5ITVJ?
LU-135 M122cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFT2[GpKSzVyPUGxMlI{ODdizszN M2fTNXNCVkeHUh?=
ES7 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4K0bmlEPTB;MUGuN|MyOyEQvF2= M3j4WHNCVkeHUh?=
SK-HEP-1 MnLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFzLke2OFYh|ryP MVjTRW5ITVJ?
BEN NIfsXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jpSmlEPTB;MUGuPFUyKM7:TR?= MWnTRW5ITVJ?
NCI-H1770 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrafnBPUUN3ME2xNk4yOjZizszN M3jzVnNCVkeHUh?=
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MZ1-PC NXn4NZI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TUXGlEPTB;MUKuOVQ2OiEQvF2= MYjTRW5ITVJ?
Mo-T MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTF{Lke0NlEh|ryP M1L4NHNCVkeHUh?=
HLE NEXLbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHiyb5FKSzVyPUGyMlgzOTVizszN M{HST3NCVkeHUh?=
RCC10RGB M1TpWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXUTWM2OD1zMz62O|Eh|ryP MlHmV2FPT0WU
COLO-320-HSR M{TuN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXw[443UUN3ME2xN{44OzhzIN88US=> MYHTRW5ITVJ?
BHT-101 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXyVYk4UUN3ME2xN{45OzR3IN88US=> Mo\HV2FPT0WU
OCUB-M MkPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGi2UZBKSzVyPUG0MlE3ODJizszN NVzMV5pMW0GQR1XS
MEG-01 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTyTWM2OD1zND6zO|A5KM7:TR?= M4HjV3NCVkeHUh?=
RS4-11 MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O5SmlEPTB;MUSuO|QzKM7:TR?= MVfTRW5ITVJ?
MN-60 M{O3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF2Lke4PVQh|ryP M1\3fnNCVkeHUh?=
NCI-H1304 M2C0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTF3LkC0NlUh|ryP Mo\3V2FPT0WU
Ramos-2G6-4C10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13WTmlEPTB;MUWuNFU5OSEQvF2= M4HjVXNCVkeHUh?=
NCI-H2342 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH62fHhKSzVyPUG1MlIxPDRizszN NXywdXZXW0GQR1XS
LAN-6 NXz1O|BkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrGTmRUUUN3ME2xOU41PDF2IN88US=> M17MdnNCVkeHUh?=
JVM-2 M{jGfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTF3LkW3OFgh|ryP NV\TeoZLW0GQR1XS
P30-OHK MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDMdIZKSzVyPUG2MlA3OTRizszN NGK4WG5USU6JRWK=
C-33-A M{TBOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDxbYpwUUN3ME2xOk43OjF2IN88US=> MkLjV2FPT0WU
RPMI-8866 M1PSbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPSOFRKSzVyPUG2Mlg1QTZizszN NYT4fINmW0GQR1XS
NCI-H630 M3TiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPaeFJKSzVyPUG2Mlg2OzdizszN MmmyV2FPT0WU
KYSE-140 NWjJZoh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELke5NKSzVyPUG3MlIxOjhizszN MkmyV2FPT0WU
T84 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvNblFKSzVyPUG4Mlg3QTVizszN NF\1U|hUSU6JRWK=
KU-19-19 NUPlVodpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXZTWM2OD1zOD65OlA5KM7:TR?= NUfkNldkW0GQR1XS
BALL-1 NIPOc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTKfoZEUUN3ME2xPU4{Ozl7IN88US=> M3n1[HNCVkeHUh?=
Calu-6 MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLCTWM2OD1zOT60PVIh|ryP NVjhPXFsW0GQR1XS
EGI-1 NV31PZJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTF7LkW5PEDPxE1? MmPJV2FPT0WU
MFH-ino NULlZWFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojnTWM2OD1zOT63OFU1KM7:TR?= NInZTGRUSU6JRWK=
GB-1 MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T0OWlEPTB;MkCuN|U{PSEQvF2= MnLIV2FPT0WU
NCI-H1693 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO1ZZV1UUN3ME2yNE43PTB3IN88US=> MkHWV2FPT0WU
SW1116 MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETERlJKSzVyPUKwMlk{PjJizszN M3rub3NCVkeHUh?=
H-EMC-SS Mnu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fENmlEPTB;MkKuNFQ2KM7:TR?= M1nqUnNCVkeHUh?=
D-502MG NIO5eWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJ{LkiyOlEh|ryP MYPTRW5ITVJ?
IA-LM NVTIW44zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfpXmpKSzVyPUKzMlI1QTNizszN M2PkNXNCVkeHUh?=
SW1463 NIDXPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jXfGlEPTB;MkOuO|kh|ryP NV3MbHRFW0GQR1XS
JAR M{TOdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXM[m5XUUN3ME2yOE4{Ojl|IN88US=> MmjrV2FPT0WU
HT M4LieGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrXZ2RMUUN3ME2yOE41PzV|IN88US=> MV;TRW5ITVJ?
LCLC-103H MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDzToZKSzVyPUK0Mlg1PDlizszN MmfEV2FPT0WU
SNU-449 NFnwTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJ2Lki3OFEh|ryP MmGwV2FPT0WU
KE-37 M3;vbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3hfXlKSzVyPUK1MlA6OjhizszN NEK1UnFUSU6JRWK=
NCI-H1623 NVPpbZZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;VbndKSzVyPUK3MlE{ODNizszN NVXpS3Z[W0GQR1XS
MOLT-13 NEPpZ3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HlUWlEPTB;MkeuN|UyPiEQvF2= MV3TRW5ITVJ?
COLO-741 NIfNNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTNzLkOzN|Mh|ryP NIeyPIRUSU6JRWK=
NB6 NH3JSG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHvTllWUUN3ME2zNk4zQDd4IN88US=> MmLVV2FPT0WU
MOLT-16 NHLBd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DuR2lEPTB;M{OuNFA2PSEQvF2= NX21eJpSW0GQR1XS
IST-MES1 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTN2LkC1OFEh|ryP NXvwclZ[W0GQR1XS
A4-Fuk NIGxeW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX3d5FKSzVyPUO1MlA3PiEQvF2= NGfPfllUSU6JRWK=
CAL-85-1 M{XzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moj3TWM2OD1|NT6yPFE4KM7:TR?= NIrXd3dUSU6JRWK=
CCRF-CEM M2\WV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTN5LkG1N|Yh|ryP NIPYfXZUSU6JRWK=
HAL-01 M1fBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfTTWM2OD1|OD60PFg6KM7:TR?= NWTvSFFrW0GQR1XS
HEL MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTR|LkO0NFkh|ryP NXe5NoxQW0GQR1XS
EW-1 M3\JNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrkTWM2OD12Mz60O|Y5KM7:TR?= NHruN|FUSU6JRWK=
MDA-MB-231 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z1UWlEPTB;NEWuNVE6QSEQvF2= NXKyfYZ[W0GQR1XS
ABC-1 M3TDdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTR4Lki1N|gh|ryP NFHOR5BUSU6JRWK=
NCI-H446 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTtTWM2OD12OD61NFU5KM7:TR?= NWGyUoRzW0GQR1XS
MHH-PREB-1 NYXhVFRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnTfIVKSzVyPUS5MlYxODdizszN M{LqU3NCVkeHUh?=
DOHH-2 Mk\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PsfWlEPTB;NEmuOlY2PiEQvF2= MV;TRW5ITVJ?
GCT MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfjTWM2OD12OT62PVc3KM7:TR?= MnG4V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]
臨床試験 A Phase II study of 17-AAG in patients with relapsed/refractory CD30 plus anaplastic large cell lymphoma (ALCL) relapsed/refractory mantle cell lymphoma (MCL) and relapsed/refractory classical Hodgkin's lymphoma (HL) has been completed.
特集 Displays very low toxicity toward normal cells.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Hsp90 binding assays Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.

細胞アッセイ: [1]

細胞株 BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 5 days
実験の流れ Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.

動物実験: [2]

動物モデル Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
製剤 Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
投薬量 ~50 mg/kg
投与方法 Injection i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download 17-AAG (Tanespimycin) SDF
分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管 3年-20℃
2年-80℃in solvent
別名 CP127374,NSC-330507, KOS 953
溶解度 (25°C) * In vitro DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water <1 mg/mL
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 17-demethoxy-17-(2-propenylamino)- [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

文献中の引用 (19)

Frequently Asked Questions

  • Question 1
    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

    Answer: 17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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* 必須

Related HSP (e.g. HSP90) 阻害剤

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.

  • KNK437

    KNK437は1種のパン(pan)- HSP 阻害剤で、誘導HSPsの合成(HSP105、 HSP72,と HSP40を含める)を抑制します。

  • VER155008

    VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

  • FRAX597

    FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.

  • Luminespib (AUY-922, NVP-AUY922)

    Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090)は独特な triazolone-containing Hsp90阻害剤、 IC50 が4 nM となる.

  • 17-DMAG (Alvespimycin) HCl

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    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    ノーカット二量体Hsp90またはN末端領域Hsp90と結合している間、Geldanamycinは1.2のμMまたは0.78のμMによるKdによる天然既存のHsp90阻害剤です。

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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