17-AAG (Tanespimycin) 化学構造
分子量: 585.69

高品質保証

カスタマーフィードバック(7)

Quality Control & MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 17-AAG (Tanespimycin)は、5nMのIC50による強力な熱ショックタンパク質90(Hsp90)阻害剤です。
ターゲット HSP90
IC50 5 nM [1]
In vitro試験 17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A549 NVTidIpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGWxdZdKSzVyPUCuNFAxOzB|IN88US=> M{fMWnNCVkeHUh?=
IST-MEL1 M3j6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LBeWlEPTB;MD6wNFA1ODdizszN MYrTRW5ITVJ?
NCI-SNU-1 Mm\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHQWGFKSzVyPUCuNFAzODdizszN NUOw[29VW0GQR1XS
FADU MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMECyNFkh|ryP M4fEN3NCVkeHUh?=
C32 Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\hVVcyUUN3ME2wMlAxOzB2IN88US=> NG\aTZNUSU6JRWK=
D-566MG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXy[GtJUUN3ME2wMlAxOzlizszN MlTaV2FPT0WU
LXF-289 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37lUmlEPTB;MD6wNFQyQSEQvF2= Mlf5V2FPT0WU
HGC-27 NXfselRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[0[XNKSzVyPUCuNFA2OSEQvF2= NUC2UIxQW0GQR1XS
RPMI-7951 M4DkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVG2WGNkUUN3ME2wMlAxPzF5IN88US=> MlvBV2FPT0WU
HSC-3 MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[zTVAzUUN3ME2wMlAxQTJ7IN88US=> MkWzV2FPT0WU
MIA-PaCa-2 NVywfZRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTBbpg{UUN3ME2wMlAyODB7IN88US=> NG[1SJZUSU6JRWK=
KS-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXVWJNKSzVyPUCuNFE{PTVizszN M2XLXHNCVkeHUh?=
CAL-51 NGPXXoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEG0NFUh|ryP MXjTRW5ITVJ?
MDA-MB-361 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XjRWlEPTB;MD6wNVQ6PSEQvF2= MoT6V2FPT0WU
TI-73 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEG3PVYh|ryP NWDKXnRlW0GQR1XS
AGS NWnGOVhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i2NmlEPTB;MD6wNVk{QCEQvF2= NFLHW4RUSU6JRWK=
NCI-H460 M2LPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi5eYYyUUN3ME2wMlAyQTd2IN88US=> NEW5[XpUSU6JRWK=
A204 NYHsSIQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn33TWM2OD1yLkCyNlQ6KM7:TR?= Mn\JV2FPT0WU
CHL-1 NHzxXXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7TVIlpUUN3ME2wMlAzOjVzIN88US=> MX3TRW5ITVJ?
DU-4475 MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfyWmJKSzVyPUCuNFIzPjFizszN NEjnfmlUSU6JRWK=
CGTH-W-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HKeGlEPTB;MD6wNlM1QSEQvF2= NXe2[FN{W0GQR1XS
HCC2218 MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXFTWM2OD1yLkCyOFk1KM7:TR?= NE\lVlZUSU6JRWK=
A2780 NFe2cXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojmTWM2OD1yLkCyOVMyKM7:TR?= MnTWV2FPT0WU
NCI-H720 NYHtb3BjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDGT|hOUUN3ME2wMlAzPTR4IN88US=> MXjTRW5ITVJ?
NCI-N87 NIXoVVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXZcG1OUUN3ME2wMlAzPTl|IN88US=> MmiyV2FPT0WU
CHP-212 NWLaPZllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPBUGxLUUN3ME2wMlAzPjJ6IN88US=> MlXZV2FPT0WU
NCI-H23 NWLWdHlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPnTWM2OD1yLkCyOlY2KM7:TR?= MWXTRW5ITVJ?
D-263MG MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;H[HJSUUN3ME2wMlAzPzh4IN88US=> MYXTRW5ITVJ?
ME-180 NWjQUGpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi2b|BKSzVyPUCuNFI5QTFizszN NWTxdlZYW0GQR1XS
SW982 NEDuVGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnER2FKSzVyPUCuNFI6QTlizszN M{Pj[HNCVkeHUh?=
OE19 NWr0WHVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnLTWM2OD1yLkCzNFc4KM7:TR?= NH;XenRUSU6JRWK=
SK-LU-1 MkfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17SfWlEPTB;MD6wN|A5OiEQvF2= NInBZ49USU6JRWK=
H4 M3zuUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7zOJhKSzVyPUCuNFMxQSEQvF2= NVyxdXNDW0GQR1XS
HT-144 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnOO41ZUUN3ME2wMlA{ODl|IN88US=> NXrKW5B2W0GQR1XS
SK-UT-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnFRmJKSzVyPUCuNFMyPzhizszN MkfuV2FPT0WU
D-336MG MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfyTWM2OD1yLkCzN|A6KM7:TR?= MkHLV2FPT0WU
MDA-MB-175-VII M3nmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDCTWM2OD1yLkCzN|U1KM7:TR?= MmC3V2FPT0WU
GAMG NUXBOo9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrHTWM2OD1yLkCzOFM2KM7:TR?= MnHoV2FPT0WU
CP50-MEL-B NIm1ZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPsS|hIUUN3ME2wMlA{PDVizszN M2ft[HNCVkeHUh?=
OVCAR-5 NWjl[Y1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\FTWM2OD1yLkCzOFgh|ryP MnrlV2FPT0WU
SK-MES-1 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEO2NFYh|ryP MmXlV2FPT0WU
VM-CUB-1 M4PuNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonmTWM2OD1yLkCzOlU4KM7:TR?= NYLWfWE5W0GQR1XS
WM-115 M1exbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXuTWM2OD1yLkCzO|YzKM7:TR?= M3KxcnNCVkeHUh?=
DSH1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEO4NFch|ryP M3S4cXNCVkeHUh?=
Becker MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEO4PFUh|ryP NYHU[|duW0GQR1XS
SW962 MmrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT5dFBKSzVyPUCuNFM6PDVizszN NI\1c2ZUSU6JRWK=
TYK-nu NGH3WVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDFcYtIUUN3ME2wMlA{QTh3IN88US=> MVnTRW5ITVJ?
HO-1-N-1 Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMESwNlEh|ryP NH7SdWtUSU6JRWK=
T98G MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDmTWM2OD1yLkC0NVA{KM7:TR?= NEKyUHdUSU6JRWK=
ACN MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLTTWM2OD1yLkC0NVYzKM7:TR?= NIfPWlFUSU6JRWK=
SW780 M2TRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfid4RKSzVyPUCuNFQzODNizszN M3jifHNCVkeHUh?=
Detroit562 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMESyN|kh|ryP MWjTRW5ITVJ?
BB49-HNC MoPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMESyOFMh|ryP NXnxeFBiW0GQR1XS
HN MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfpXlVDUUN3ME2wMlA1Ojd{IN88US=> NVjpXmlHW0GQR1XS
H9 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G0WmlEPTB;MD6wOFM4OSEQvF2= M{exR3NCVkeHUh?=
VA-ES-BJ NYHEUYtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXlTWM2OD1yLkC0OFQ4KM7:TR?= MYLTRW5ITVJ?
MEL-JUSO NIXzfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMES0O|Uh|ryP NF\GZlFUSU6JRWK=
BT-474 M2XhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMES1JO69VQ>? NV3C[IRtW0GQR1XS
CaR-1 NX\tV5RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmflTWM2OD1yLkC0OVQ6KM7:TR?= MlLXV2FPT0WU
PSN1 NInBdplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jtcmlEPTB;MD6wOFYxOyEQvF2= NYn6b4t2W0GQR1XS
KYSE-510 M3zVXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrQOFFEUUN3ME2wMlA1PjR7IN88US=> MYXTRW5ITVJ?
KP-4 NVrYZ2txT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoiyTWM2OD1yLkC0O|U{KM7:TR?= M{\wTXNCVkeHUh?=
KYSE-410 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu1TWM2OD1yLkC0O|czKM7:TR?= NIjnRpdUSU6JRWK=
G-402 M3i3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\ZeoozUUN3ME2wMlA1Pzh7IN88US=> NH;3e4JUSU6JRWK=
DOK NHHp[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DSUWlEPTB;MD6wOFkxOiEQvF2= NFLPZ5FUSU6JRWK=
COR-L88 NE[3b5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\sOGlWUUN3ME2wMlA1QTF{IN88US=> NIPYd4ZUSU6JRWK=
SKG-IIIa MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLLOYZyUUN3ME2wMlA1QTh4IN88US=> MkPkV2FPT0WU
AN3-CA NGLIbZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3riO2lEPTB;MD6wOUDPxE1? NYPIWmJZW0GQR1XS
SW48 NHT0cZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF22fnZKSzVyPUCuNFUxOzlizszN M3q1cXNCVkeHUh?=
YKG-1 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fWSmlEPTB;MD6wOVA4OSEQvF2= MXvTRW5ITVJ?
KYSE-150 M1PVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XnVWlEPTB;MD6wOVI{PSEQvF2= NVnHVFg2W0GQR1XS
HuO-3N1 NYPid2ZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{KzbWlEPTB;MD6wOVI{PyEQvF2= NIThN2JUSU6JRWK=
LB1047-RCC M2PUU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LrWmlEPTB;MD6wOVI6PiEQvF2= MYHTRW5ITVJ?
NCI-H2030 M1\OVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrCR5k4UUN3ME2wMlA2PDF2IN88US=> M1KwRXNCVkeHUh?=
YH-13 M2OyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn6TWM2OD1yLkC1O|IzKM7:TR?= M1HHenNCVkeHUh?=
5637 M1zaNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoW5TWM2OD1yLkC1O|Qh|ryP NFrk[lFUSU6JRWK=
LOXIMVI NWjLcZc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KzRmlEPTB;MD6wOVg4OiEQvF2= MYjTRW5ITVJ?
GT3TKB M3;qNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEW5OFIh|ryP M{K1N3NCVkeHUh?=
TCCSUP NE\TV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7QdWNKSzVyPUCuNFU6PjRizszN M1HiRnNCVkeHUh?=
EPLC-272H M4\YSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HVVGlEPTB;MD6wOlIxPSEQvF2= M4DCVXNCVkeHUh?=
LU-99A NFq5VGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3RcIdKSzVyPUCuNFYzOzdizszN M1nwWXNCVkeHUh?=
NCI-H1755 NIfzRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwME[zOFEh|ryP M2PYb3NCVkeHUh?=
KM12 NIraempIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTjfFhDUUN3ME2wMlA3OzR6IN88US=> MniyV2FPT0WU
SF295 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUG4XZlKUUN3ME2wMlA3PDV{IN88US=> NF7B[IxUSU6JRWK=
MZ2-MEL M4\y[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfYN5pKSzVyPUCuNFY2PTNizszN MX;TRW5ITVJ?
HEC-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvRVZNKSzVyPUCuNFY2QDhizszN MXnTRW5ITVJ?
SW684 MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwME[1PVEh|ryP NHTIfZNUSU6JRWK=
SF539 M1PtOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3iXopKSzVyPUCuNFY3QDFizszN NXnYblFNW0GQR1XS
GMS-10 NHjYe4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj2[5NKSzVyPUCuNFY3QTlizszN MX\TRW5ITVJ?
MV-4-11 M1XPRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHm5RoZKSzVyPUCuNFY5ODNizszN NILFeFZUSU6JRWK=
HT-29 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLPVppKSzVyPUCuNFY6OTlizszN M2rBSHNCVkeHUh?=
23132-87 NE\XVWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT4TIlKSzVyPUCuNFY6PSEQvF2= NHXBTpJUSU6JRWK=
SW620 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEewNlYh|ryP MVLTRW5ITVJ?
HCC1806 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjyNndKSzVyPUCuNFcyOzFizszN NYXpVm02W0GQR1XS
Hs-578-T NHz2[|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHixb4FKSzVyPUCuNFczODhizszN M{XFWnNCVkeHUh?=
A2058 M3m4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjnW5ZKSzVyPUCuNFczOjhizszN NVHaR|d{W0GQR1XS
MEL-HO NELmTmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XN[GlEPTB;MD6wO|I2PSEQvF2= M4\pV3NCVkeHUh?=
HCC2998 NYLBNlRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfQTWM2OD1yLkC3N|Q4KM7:TR?= MXjTRW5ITVJ?
HuO9 NGHhTIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjBTWM2OD1yLkC3OVg6KM7:TR?= NID1fmVUSU6JRWK=
CAL-39 M3z2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVS0cY5jUUN3ME2wMlA4PzZ4IN88US=> NVvwcXNxW0GQR1XS
M14 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\MdoJNUUN3ME2wMlA4QTF|IN88US=> NY\RNJNLW0GQR1XS
BFTC-909 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\mcWdwUUN3ME2wMlA4QTZ7IN88US=> M2faW3NCVkeHUh?=
TE-11 NHvhWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1izdWlEPTB;MD6wO|k6PiEQvF2= MlvhV2FPT0WU
TGBC1TKB MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH70R3hKSzVyPUCuNFgxPDNizszN MVTTRW5ITVJ?
L-363 MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TkfGlEPTB;MD6wPFIxPiEQvF2= NUPz[pgyW0GQR1XS
A431 NF;TfGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEiyNUDPxE1? MmXzV2FPT0WU
MKN45 MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEiyNVkh|ryP MX\TRW5ITVJ?
HT-1080 NFXIZW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX2wdlhJUUN3ME2wMlA5PDN7IN88US=> MmL5V2FPT0WU
OVCAR-8 NYnzXpNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMEi2NlIh|ryP MUPTRW5ITVJ?
LCLC-97TM1 M2DiZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fQ[GlEPTB;MD6wPFczQCEQvF2= NVe3XohkW0GQR1XS
M059J M3LwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEmwNlch|ryP Ml21V2FPT0WU
SK-MEL-2 M4HuVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH23bFNKSzVyPUCuNFkxPiEQvF2= NEnUOZJUSU6JRWK=
TE-1 M37Nemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLvNndKSzVyPUCuNFkzODRizszN MoDBV2FPT0WU
KYSE-180 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG3WI5KSzVyPUCuNFkzPjJizszN MnLBV2FPT0WU
D-247MG M1HacGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\HVmlEPTB;MD6wPVQ2PSEQvF2= MUDTRW5ITVJ?
8-MG-BA M3G5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPYTWM2OD1yLkC5OFczKM7:TR?= NV\SPVh[W0GQR1XS
NCI-H1792 M33Jd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELaTlFKSzVyPUCuNFk3OThizszN M2XxWHNCVkeHUh?=
MCF7 M{j1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjrTWM2OD1yLkC5Olc4KM7:TR?= NGnPbWpUSU6JRWK=
NCI-H2122 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\MbWlEPTB;MD6wPVc1PSEQvF2= NEeyepNUSU6JRWK=
EFO-27 NVjTfmh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETYbmdKSzVyPUCuNFk6QTdizszN MlnnV2FPT0WU
LB2241-RCC NEHre2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTqTWM2OD1yLkGwNFU1KM7:TR?= MVXTRW5ITVJ?
SN12C M2C2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLhTWM2OD1yLkGwNVA4KM7:TR?= MWXTRW5ITVJ?
A498 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq2NWQ2UUN3ME2wMlExOThizszN MmPzV2FPT0WU
PANC-03-27 NWW2eol6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nMbmlEPTB;MD6xNFI5PiEQvF2= NYnuOVJIW0GQR1XS
NCI-H1581 NHvWclVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv0TWM2OD1yLkGwNlkh|ryP MmK3V2FPT0WU
U-87-MG NVzPcmQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLhUndoUUN3ME2wMlExOzB5IN88US=> M2HJO3NCVkeHUh?=
G-401 MonwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn3TWM2OD1yLkGwN|U{KM7:TR?= NVjaZ2JoW0GQR1XS
SiHa NIPNSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvRTWM2OD1yLkGwOFg3KM7:TR?= MmP5V2FPT0WU
U251 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3CcpRKSzVyPUCuNVA2OjVizszN MkTnV2FPT0WU
MMAC-SF MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn6TWM2OD1yLkGwOVMyKM7:TR?= NXHS[5liW0GQR1XS
BB65-RCC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rxV2lEPTB;MD6xNFU2PCEQvF2= Mn6xV2FPT0WU
NKM-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTEdm5KSzVyPUCuNVA3PjZizszN M3u2WnNCVkeHUh?=
HD-MY-Z NYr2c3lOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K2SmlEPTB;MD6xNFg4OyEQvF2= MVjTRW5ITVJ?
TGBC11TKB M3\VPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXIeZRKSzVyPUCuNVA6ODNizszN NGHKTWtUSU6JRWK=
COLO-679 M2H5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjlTGRKSzVyPUCuNVEzOTFizszN MV3TRW5ITVJ?
TE-8 M{i5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXXTWM2OD1yLkGxNlY1KM7:TR?= MXXTRW5ITVJ?
SK-MEL-28 NIHqd5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\lOIZKSzVyPUCuNVE{OjFizszN NVTPOGJEW0GQR1XS
SH-4 NHzEVHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\nNoVyUUN3ME2wMlEyOzV4IN88US=> MkjsV2FPT0WU
KALS-1 NGO0OmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3IXlQ4UUN3ME2wMlEyOzl|IN88US=> NIP0NoNUSU6JRWK=
RKO MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\uXWZ[UUN3ME2wMlEyPzZ2IN88US=> MW\TRW5ITVJ?
OMC-1 M{fsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMUG3PVch|ryP MVHTRW5ITVJ?
BT-549 NYq4b5F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXqfmY2UUN3ME2wMlEyPzl7IN88US=> NXX1ZnpnW0GQR1XS
NCI-H28 NWGzdmNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMUG4NVch|ryP NYq4NlEyW0GQR1XS
RXF393 NVvuW|RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jYTGlEPTB;MD6xNVk5OiEQvF2= MWHTRW5ITVJ?
COLO-829 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMUKwNFUh|ryP M2q1OHNCVkeHUh?=
HMV-II MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PHPGlEPTB;MD6xNlAzKM7:TR?= MojQV2FPT0WU
SW1990 M4j5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O2SWlEPTB;MD6xNlE2PyEQvF2= NH7ZelVUSU6JRWK=
NCI-H1437 NVvEephkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf4TWM2OD1yLkGyNVU4KM7:TR?= NGTaXFNUSU6JRWK=
SNB75 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMUKxOlkh|ryP NGHhbFRUSU6JRWK=
EW-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHxZnZPUUN3ME2wMlEzPjZzIN88US=> NULXUm9QW0GQR1XS
SAS NVLCN|VxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OxWGlEPTB;MD6xNlY6KM7:TR?= NVLl[XBnW0GQR1XS
NCI-H1666 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\5dHpVUUN3ME2wMlEzPzd2IN88US=> MVrTRW5ITVJ?
A375 Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[wTWM2OD1yLkGyO|c5KM7:TR?= MYfTRW5ITVJ?
CAMA-1 NXLLNpZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMUK5NlQh|ryP M120SXNCVkeHUh?=
HuP-T4 M1\jPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDLTWM2OD1yLkGyPVQ{KM7:TR?= NV30eIpoW0GQR1XS
NCI-H292 M3P1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jBcmlEPTB;MD6xN|EyKM7:TR?= MWnTRW5ITVJ?
PC-14 M1LNNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\jcFBKSzVyPUCuNVMzOTFizszN MoL1V2FPT0WU
BPH-1 NVO2cmdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfQTWM2OD1yLkGzOFEh|ryP MmW1V2FPT0WU
GAK MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTYTWM2OD1yLkGzOVY4KM7:TR?= M3;vXHNCVkeHUh?=
VMRC-RCZ NFjXWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\FVWlEPTB;MD6xN|c3OiEQvF2= Ml;SV2FPT0WU
SK-MEL-24 Mk\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHNOFhKSzVyPUCuNVM5PyEQvF2= MlW2V2FPT0WU
LB831-BLC MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDiNYdSUUN3ME2wMlE{QDh|IN88US=> MV;TRW5ITVJ?
NCI-H2452 M{f5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMUO5OVYh|ryP NGT5W4hUSU6JRWK=
RT-112 M3;GUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L3VGlEPTB;MD6xOFA{PSEQvF2= M1fYNnNCVkeHUh?=
GP5d MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnPOFJKSzVyPUCuNVQyODRizszN NFTx[W5USU6JRWK=
LC-2-ad NED1ZYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LBUGlEPTB;MD6xOFEzOSEQvF2= MWXTRW5ITVJ?
MPP-89 NWnJZ2xuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPpTWM2OD1yLkG0NVI2KM7:TR?= MXHTRW5ITVJ?
NUGC-3 Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMUS0O|gh|ryP M12yV3NCVkeHUh?=
GI-1 NFPtXnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rKPGlEPTB;MD6xOFU2QCEQvF2= NV\aTIhxW0GQR1XS
HCC1419 NIHjO4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfBOWNKSzVyPUCuNVQ2PzZizszN MWrTRW5ITVJ?
SW1573 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\rTWM2OD1yLkG0O|U5KM7:TR?= M1LBSHNCVkeHUh?=
NCI-H2347 M2PZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XSUGlEPTB;MD6xOFg{QSEQvF2= M3;DXXNCVkeHUh?=
Mewo NX62folTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMUS4PFkh|ryP M2rsR3NCVkeHUh?=
639-V MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMUWwNVMh|ryP NFvQUHlUSU6JRWK=
AsPC-1 MlTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3oNZdFUUN3ME2wMlE2OjJ3IN88US=> NHi0U4tUSU6JRWK=
NCI-H1648 MmHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfaTWM2OD1yLkG1NlMzKM7:TR?= NGTudm1USU6JRWK=
786-0 M2nON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMUWzPFEh|ryP M{W4bHNCVkeHUh?=
ETK-1 M{fxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETKPHlKSzVyPUCuNVU6KM7:TR?= MYfTRW5ITVJ?
BxPC-3 MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoD4TWM2OD1yLkG1PVY3KM7:TR?= NI\YbVNUSU6JRWK=
CAL-62 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfQN4pyUUN3ME2wMlE3OTZ7IN88US=> NVrHcWt{W0GQR1XS
HCC1937 NFr2ZWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzzSYZbUUN3ME2wMlE3Ojd3IN88US=> MXzTRW5ITVJ?
NCI-H1299 NWf5SYFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHiTWM2OD1yLkG2Nlg2KM7:TR?= MnzaV2FPT0WU
SW1088 NHjKWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPaUINKSzVyPUCuNVY1OTNizszN Mn7KV2FPT0WU
FTC-133 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGyNlhKSzVyPUCuNVY2PCEQvF2= MW\TRW5ITVJ?
OC-314 MlXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjlTWM2OD1yLkG2Olkh|ryP MY\TRW5ITVJ?
SCC-9 NEDibW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nweWlEPTB;MD6xOlcyPiEQvF2= NYCxXYd2W0GQR1XS
HT-1376 NIH6fHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:xN2lEPTB;MD6xOlk{PiEQvF2= Mn60V2FPT0WU
U-2-OS MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXITWM2OD1yLkG3NVc{KM7:TR?= M{fs[3NCVkeHUh?=
COLO-824 NES1eFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;GbnZKSzVyPUCuNVczQTRizszN MWXTRW5ITVJ?
BB30-HNC MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMUezN{DPxE1? M{fp[3NCVkeHUh?=
NCI-H2087 NEDOeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;KV5lKSzVyPUCuNVc{PjhizszN M1TsUnNCVkeHUh?=
NCI-H2170 Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[1TWM2OD1yLkG3OVM3KM7:TR?= M{fCc3NCVkeHUh?=
SK-OV-3 NFKweIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrGOpJKSzVyPUCuNVc2PzFizszN M2e4cHNCVkeHUh?=
MZ7-mel M4f4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX24d3ZbUUN3ME2wMlE4PjR7IN88US=> MWnTRW5ITVJ?
NCI-H650 MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DFdGlEPTB;MD6xO|Y5OiEQvF2= NEnrTWxUSU6JRWK=
KOSC-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33vbmlEPTB;MD6xO|c{PCEQvF2= MlnmV2FPT0WU
SCC-4 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L4OGlEPTB;MD6xO|c4PyEQvF2= NFSxUopUSU6JRWK=
MDA-MB-157 NEXPdIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XLcmlEPTB;MD6xPFA5OiEQvF2= M1HvUXNCVkeHUh?=
KYSE-520 NXHWV|FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\5TWM2OD1yLkG4NkDPxE1? M4HIdXNCVkeHUh?=
LK-2 MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fsXGlEPTB;MD6xPFMxOyEQvF2= NVTQbXVOW0GQR1XS
KNS-81-FD NH24[VlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrTTWM2OD1yLkG4N|k1KM7:TR?= NXyxUoZOW0GQR1XS
IGROV-1 MkjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX3d4g2UUN3ME2wMlE5PDR|IN88US=> NWHiO5VVW0GQR1XS
DEL NWfadYVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHu[JZKSzVyPUCuNVg1PSEQvF2= NVvtRYdMW0GQR1XS
NCI-H1395 MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzuTWM2OD1yLkG4OlgzKM7:TR?= MUnTRW5ITVJ?
JEG-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDJVGVYUUN3ME2wMlE5PzB3IN88US=> M2S5fnNCVkeHUh?=
BCPAP MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37XXGlEPTB;MD6xPFg4OiEQvF2= MkjKV2FPT0WU
CAL-27 NInQXHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHCTWM2OD1yLkG5NFIzKM7:TR?= NHfOcYpUSU6JRWK=
RD MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLGeIdKSzVyPUCuNVkyOTNizszN MkXMV2FPT0WU
RVH-421 NXOwOnNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMUmxNVYh|ryP NX7pTINVW0GQR1XS
Capan-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHocZRKSzVyPUCuNVkzPTZizszN NIjQeJZUSU6JRWK=
COLO-680N NIXH[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMUmzOlQh|ryP MXTTRW5ITVJ?
NCI-H1650 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzMVHV7UUN3ME2wMlIxODV5IN88US=> NIHTOY9USU6JRWK=
SBC-5 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLvTWM2OD1yLkKwNVE5KM7:TR?= NX\KPWw{W0GQR1XS
U031 Ml35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W1emlEPTB;MD6yNFU1PyEQvF2= MkWzV2FPT0WU
S-117 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT4dJNKSzVyPUCuNlA2PjRizszN M1LlW3NCVkeHUh?=
DoTc2-4510 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nqbGlEPTB;MD6yNFc3QSEQvF2= MorlV2FPT0WU
AM-38 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVSzcWwxUUN3ME2wMlIxQDR6IN88US=> NY\FS241W0GQR1XS
A172 M{PPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TDTWlEPTB;MD6yNVAzOiEQvF2= NULtcG1zW0GQR1XS
HPAF-II M37udWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDyZlRKSzVyPUCuNlEzPjRizszN NV3EUlFsW0GQR1XS
769-P MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX2WGVKSzVyPUCuNlEzQCEQvF2= MVfTRW5ITVJ?
MFE-280 NUG4OFROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS4S25rUUN3ME2wMlIyOjl6IN88US=> MnjSV2FPT0WU
TE-9 NUDDVI44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rSfGlEPTB;MD6yNVc5PiEQvF2= MkLwV2FPT0WU
C2BBe1 M4PXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMkKxPUDPxE1? NIfCeZhUSU6JRWK=
EoL-1-cell M3TuXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIe1XGtKSzVyPUCuNlIzODNizszN MmTVV2FPT0WU
G-361 NGHDNJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nnRWlEPTB;MD6yNlY5OiEQvF2= M2DQfHNCVkeHUh?=
KYSE-270 M1[3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[2TlJKSzVyPUCuNlMxQDRizszN MlrwV2FPT0WU
TK10 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMkOxNVch|ryP MoCyV2FPT0WU
ML-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT5cZRFUUN3ME2wMlI{OTF7IN88US=> M4rXenNCVkeHUh?=
MHH-ES-1 NIPjbY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMkO2PFEh|ryP NE\ZR3VUSU6JRWK=
BHY NVjkOGVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:4O4RRUUN3ME2wMlI{PjlzIN88US=> NYnCU45SW0GQR1XS
LS-513 Mo[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMkO5OlEh|ryP NXHVXodHW0GQR1XS
COLO-678 NWLqVW0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH65ZWtKSzVyPUCuNlQxPDRizszN MkHhV2FPT0WU
NCI-H747 NYPtenJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPTV|doUUN3ME2wMlI1OTZ7IN88US=> MVfTRW5ITVJ?
K5 NGrYRYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMkSzPEDPxE1? NX\UVHpzW0GQR1XS
OS-RC-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTybHBKSzVyPUCuNlQ2ODlizszN Mo\vV2FPT0WU
KINGS-1 NFTBVHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj3cHdKSzVyPUCuNlQ2OjlizszN MWPTRW5ITVJ?
SCC-25 M1P6emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMkS1OlMh|ryP NHrRfWZUSU6JRWK=
CAPAN-1 NEjrNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMkS3PFMh|ryP MoP2V2FPT0WU
ESS-1 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV23bXVHUUN3ME2wMlI1QDB3IN88US=> M3rX[3NCVkeHUh?=
TE-6 NXzEUpZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPlcI5uUUN3ME2wMlI2PzVizszN MXTTRW5ITVJ?
LB2518-MEL MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L4VWlEPTB;MD6yOVc4PyEQvF2= NG\VRWVUSU6JRWK=
COLO-800 NXjZcmd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ix[GlEPTB;MD6yOVgyOiEQvF2= MYDTRW5ITVJ?
LU-134-A NV\oUnUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMk[xN|Yh|ryP NGPnfG1USU6JRWK=
NCI-H1155 NH7zXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HwT2lEPTB;MD6yOlE3OiEQvF2= MUDTRW5ITVJ?
MFM-223 NFXWNJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3rS2tZUUN3ME2wMlI3OzZ|IN88US=> MWPTRW5ITVJ?
HTC-C3 NHi0WYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEmxOXRKSzVyPUCuNlY2ODZizszN NHjhRlRUSU6JRWK=
HCT-116 MmT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfmNYdKSzVyPUCuNlY2QTlizszN NFHnTVlUSU6JRWK=
Ca-Ski MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;vUWlEPTB;MD6yOlY4QCEQvF2= MVzTRW5ITVJ?
SBC-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTkTWM2OD1yLkK2O|QzKM7:TR?= NGKxbYpUSU6JRWK=
NB69 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;vSGlEPTB;MD6yO|A5PyEQvF2= MmW4V2FPT0WU
J82 NU[3flNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjDRYtxUUN3ME2wMlI4OjZ3IN88US=> MnLnV2FPT0WU
U-118-MG MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfQTWM2OD1yLkK3OVc6KM7:TR?= M{KwNHNCVkeHUh?=
NCI-H1355 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHmTWM2OD1yLkK4NFc1KM7:TR?= NIPVWmlUSU6JRWK=
NCI-H1048 NYjqU2VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\aU|lKSzVyPUCuNlg6PTZizszN M4XiUHNCVkeHUh?=
SW954 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3XTWM2OD1yLkK5NlI4KM7:TR?= Mn;RV2FPT0WU
NMC-G1 NIfDS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXpOZNXUUN3ME2wMlI6Ojd5IN88US=> NYTUdIRkW0GQR1XS
SW1710 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\4bWlEPTB;MD6yPVQ6PCEQvF2= NWX2VI97W0GQR1XS
KY821 NV3YOYR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXf0WmliUUN3ME2wMlI6QDd{IN88US=> NFfo[JRUSU6JRWK=
HCC38 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE[5[YNKSzVyPUCuN|AxPzhizszN NH\nfIhUSU6JRWK=
NCI-SNU-5 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzQTWM2OD1yLkOwOVQh|ryP M{\1PHNCVkeHUh?=
ES8 M2HSbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPVOFJMUUN3ME2wMlMxPzh2IN88US=> NHKwdIlUSU6JRWK=
COLO-792 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjqN2RKSzVyPUCuN|EzPTFizszN MV;TRW5ITVJ?
BFTC-905 NFvhSllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHOd2hKSzVyPUCuN|E2OjFizszN MlXrV2FPT0WU
ChaGo-K-1 M4HpRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHGxfVRKSzVyPUCuN|E4OTVizszN NYTCSFZGW0GQR1XS
Daoy NWO4WZFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwM{G3NlMh|ryP M{PkbXNCVkeHUh?=
SJSA-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTZdmhKSzVyPUCuN|E5PDdizszN MlLBV2FPT0WU
KNS-62 M4XTXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDl[5VKSzVyPUCuN|IxQDhizszN NE\E[WJUSU6JRWK=
CAKI-1 NVy0XYQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPZZphEUUN3ME2wMlMzOTFzIN88US=> MX\TRW5ITVJ?
UACC-62 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[5c4kzUUN3ME2wMlMzOjJ5IN88US=> NEnUT2dUSU6JRWK=
HuCCT1 NYOwemlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTMWHJQUUN3ME2wMlMzOjh|IN88US=> MXvTRW5ITVJ?
CTB-1 MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonvTWM2OD1yLkOyO|U{KM7:TR?= MXjTRW5ITVJ?
NTERA-S-cl-D1 NU[zWHdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrTcYIyUUN3ME2wMlMzQDN4IN88US=> NUfJT|hZW0GQR1XS
T-24 NUnyVpBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfObXBKSzVyPUCuN|MyPTlizszN NUe4TYxZW0GQR1XS
KYSE-70 M17WSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwM{OyPFMh|ryP MlryV2FPT0WU
SW626 NIfyTphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr1TWM2OD1yLkOzOVMzKM7:TR?= NGHSbHFUSU6JRWK=
LB996-RCC NVfteox{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\H[mlEPTB;MD6zN|YyQSEQvF2= NIHXUmVUSU6JRWK=
DMS-273 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYS0RpZDUUN3ME2wMlM{QTF4IN88US=> NI\yS4JUSU6JRWK=
SW1783 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljwTWM2OD1yLkOzPVk4KM7:TR?= NVzCSHVyW0GQR1XS
KU812 M2nwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwM{SwN|gh|ryP NVizWm5MW0GQR1XS
HSC-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLZV25OUUN3ME2wMlM1ODV|IN88US=> MX\TRW5ITVJ?
A3-KAW MlLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHqwUJpKSzVyPUCuN|QyPjJizszN Ml\HV2FPT0WU
COLO-684 M2jpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnt[I1KSzVyPUCuN|Q2ODFizszN M1fuU3NCVkeHUh?=
NCI-H2405 M17hSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrWO2NGUUN3ME2wMlM1PjNzIN88US=> MkC0V2FPT0WU
NCI-H2228 NXLrb5FxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DIWmlEPTB;MD6zOVM2PyEQvF2= NWPXRYt3W0GQR1XS
NB13 MkLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDCZXFbUUN3ME2wMlM3QDJ7IN88US=> NEXVRXlUSU6JRWK=
no-11 NETkXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\3fVRKSzVyPUCuN|Y6PSEQvF2= NFvOPGlUSU6JRWK=
DK-MG MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwM{exPFgh|ryP MmPQV2FPT0WU
NBsusSR MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlK4TWM2OD1yLkO3Nlg2KM7:TR?= MYXTRW5ITVJ?
KP-N-YS NWnvSVg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwM{e0OlMh|ryP MoD5V2FPT0WU
CFPAC-1 NWLsZolTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwM{e1NVgh|ryP NGLET5FUSU6JRWK=
KARPAS-45 Ml7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwM{e4OlIh|ryP MYDTRW5ITVJ?
NCI-H1793 NFXQendIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\2fXdKSzVyPUCuN|g2OSEQvF2= MljBV2FPT0WU
HCE-T MlPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;ncmlEPTB;MD6zPFYxOyEQvF2= NU\jPGc1W0GQR1XS
NCI-H520 NVzqOVNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF76bFZKSzVyPUCuN|g4ODNizszN Mk\jV2FPT0WU
HCC2157 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DmXGlEPTB;MD6zPFc5OSEQvF2= NIC4dXFUSU6JRWK=
EW-18 NWX1WG56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LJSmlEPTB;MD6zPFk1OSEQvF2= M3rCU3NCVkeHUh?=
RO82-W-1 NUDYfnFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z4SGlEPTB;MD6zPVY6QSEQvF2= M3;Oc3NCVkeHUh?=
HuP-T3 M1\rdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LPZmlEPTB;MD60NFE1OyEQvF2= MX3TRW5ITVJ?
PANC-10-05 NGnkOmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf6e4x7UUN3ME2wMlQyOTdizszN M37Y[nNCVkeHUh?=
NCI-H1703 MnLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfMTWM2OD1yLkSxOFQ3KM7:TR?= NVvpNJc2W0GQR1XS
TE-10 NWXqbY1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jNXmlEPTB;MD60NVQ1PyEQvF2= NFnlXnFUSU6JRWK=
HOS NHribnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwNEG2PFIh|ryP NF7jNWRUSU6JRWK=
LN-405 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M174VmlEPTB;MD60NVY5PyEQvF2= MoTJV2FPT0WU
A427 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfQPFZKSzVyPUCuOFE6QDFizszN MWjTRW5ITVJ?
CAL-12T MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwNEK3PEDPxE1? NXXQOo5WW0GQR1XS
SW756 NWfRe5Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17GTGlEPTB;MD60OFE5OyEQvF2= M1q0b3NCVkeHUh?=
YAPC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nreGlEPTB;MD60OVA5KM7:TR?= MXzTRW5ITVJ?
GOTO NEPSXWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXnOZVKSzVyPUCuOFUyPiEQvF2= M{Dud3NCVkeHUh?=
C3A NEHnNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O2ZWlEPTB;MD60OVQ{PyEQvF2= NYnFN4h6W0GQR1XS
UM-UC-3 NILqS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL0SHM4UUN3ME2wMlQ2PDdizszN MW\TRW5ITVJ?
NCI-H1573 NGfQWY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DFRmlEPTB;MD60OVU3QSEQvF2= MlPzV2FPT0WU
LS-411N MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17zWGlEPTB;MD60OlUzPyEQvF2= NULMOFNOW0GQR1XS
COR-L23 M3vrXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLuTWM2OD1yLkS2O|Y1KM7:TR?= MlXqV2FPT0WU
HCE-4 NWD1U5F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP4UnZKSzVyPUCuOFc1PDZizszN MWHTRW5ITVJ?
NCI-H2291 M{DHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwNEe4PVYh|ryP MYrTRW5ITVJ?
A101D MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTmSlFqUUN3ME2wMlQ5ODV|IN88US=> NWrWXYRDW0GQR1XS
HT-3 M{TJT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwNEiyNVch|ryP NXPQN4ZsW0GQR1XS
HOP-62 M{DDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[xZpFKUUN3ME2wMlQ6QDZ3IN88US=> M1[1SXNCVkeHUh?=
PC-3 M17QWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjCT|VKSzVyPUCuOVE2ODdizszN NF3JWmpUSU6JRWK=
CTV-1 MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlntTWM2OD1yLkWyOlY6KM7:TR?= M4jTc3NCVkeHUh?=
PANC-08-13 MnPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwNUOxO|ch|ryP MVLTRW5ITVJ?
CAL-120 M1z0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nsb2lEPTB;MD61N|M6QSEQvF2= M3HSO3NCVkeHUh?=
UMC-11 NVnETY5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\wTWM2OD1yLkW1NlM1KM7:TR?= M{jzSHNCVkeHUh?=
MSTO-211H M1vHUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rOTGlEPTB;MD61OVc3OiEQvF2= MXvTRW5ITVJ?
NCI-H2126 M3HwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XNfmlEPTB;MD61OlgyPSEQvF2= NGHTellUSU6JRWK=
SNU-C2B MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjUWZJKSzVyPUCuOVc6PzdizszN Ml\rV2FPT0WU
DBTRG-05MG MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwNUiwOVMh|ryP MXPTRW5ITVJ?
MKN1 NFW2dnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwNUi3PFMh|ryP MofIV2FPT0WU
ES3 NFfET2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwNUmxNlQh|ryP MnS2V2FPT0WU
OVCAR-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;tVmlEPTB;MD61PVM1OSEQvF2= Mki4V2FPT0WU
ACHN M17XZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1K4cWlEPTB;MD62NFU3QSEQvF2= NYDzd|VtW0GQR1XS
SW872 NYrwXoZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHrZW9EUUN3ME2wMlYxPzZ|IN88US=> M1r0NHNCVkeHUh?=
CP66-MEL NEDGbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfTTWM2OD1yLk[wPVY6KM7:TR?= MoL0V2FPT0WU
NCI-H661 NFPYNYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nDNWlEPTB;MD62NVExPCEQvF2= M3;2NXNCVkeHUh?=
UACC-893 NXvqeJY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXiTWM2OD1yLk[zOlgyKM7:TR?= NGD6bnVUSU6JRWK=
JVM-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\h[XpKSzVyPUCuOlM5ODRizszN MWTTRW5ITVJ?
SF268 NUHxTow2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUO1cpVtUUN3ME2wMlY1OzR7IN88US=> MlXEV2FPT0WU
OCI-AML2 NI\BPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwNkWzPVch|ryP M1z6Z3NCVkeHUh?=
RPMI-8226 NWruWXNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwNk[zNlMh|ryP NEO5OIxUSU6JRWK=
MKN28 NIrHUIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwNk[2NlQh|ryP MljKV2FPT0WU
MDA-MB-453 M4nkVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\aTYlKSzVyPUCuOlcyQCEQvF2= NVnuVpQyW0GQR1XS
BV-173 NHraR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwNki2O|kh|ryP NVGzd2hZW0GQR1XS
NCI-H358 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP2TWM2OD1yLk[4O|I3KM7:TR?= MYfTRW5ITVJ?
NCI-H1651 NGXIXHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXxTWM2OD1yLkeg{txO MlPuV2FPT0WU
MDA-MB-415 M1zkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j1XmlEPTB;MD63NFgzQSEQvF2= NHGzeHBUSU6JRWK=
8305C MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq5OpdJUUN3ME2wMlczPDl6IN88US=> MUHTRW5ITVJ?
EFM-19 NXjXNHVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjTUIRKSzVyPUCuO|M3PzFizszN NI\jPJJUSU6JRWK=
RERF-LC-MS NHziRoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXic2FSUUN3ME2wMlc1PjF|IN88US=> MX3TRW5ITVJ?
A388 NIr5d2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkiwTWM2OD1yLke2OFY4KM7:TR?= MoDxV2FPT0WU
GI-ME-N M{ixcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fDS2lEPTB;MD63O|I{PSEQvF2= M{XEe3NCVkeHUh?=
IGR-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnhTWM2OD1yLke5NFQ{KM7:TR?= M{LZRnNCVkeHUh?=
LNCaP-Clone-FGC NXrIT|d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjMO41KSzVyPUCuPFAxODRizszN MoHPV2FPT0WU
SK-MEL-3 M3LVZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnldmVvUUN3ME2wMlgyPTB6IN88US=> NFH4TYtUSU6JRWK=
UACC-257 NVvJNo9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TKTmlEPTB;MD64NlI{OSEQvF2= NF\6enlUSU6JRWK=
OE33 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULLPGpxUUN3ME2wMlg2OTBzIN88US=> MV7TRW5ITVJ?
QIMR-WIL M1vKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnqTWM2OD1yLki1NVQyKM7:TR?= Mm\jV2FPT0WU
NCI-H2009 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDrXGFKSzVyPUCuPFU{OTFizszN NEHtb2JUSU6JRWK=
NCI-H522 MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XCS2lEPTB;MD64O|c5OyEQvF2= NU\ZNno6W0GQR1XS
Saos-2 NVPlVJpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnMTWM2OD1yLki3PFcyKM7:TR?= NFrhNWNUSU6JRWK=
NB17 NXnF[nJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnOzTWM2OD1yLki4NFI2KM7:TR?= M2L6[XNCVkeHUh?=
D-392MG M3nTXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwOEmzOVYh|ryP NF;DRXJUSU6JRWK=
SHP-77 NYLsbWNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPDN41SUUN3ME2wMlkxPDh3IN88US=> M{CwV3NCVkeHUh?=
SK-MEL-30 NVK2ZmpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwOUGxPFUh|ryP NHi3c45USU6JRWK=
GCIY NF\aeppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwOUG4OFMh|ryP NILhTXFUSU6JRWK=
HCC70 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH32UZFKSzVyPUCuPVIxPTlizszN NH3GdI1USU6JRWK=
LU-65 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTIUmZKSzVyPUCuPVI2QTFizszN MkXTV2FPT0WU
NCI-H1563 NVfRNXZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H3RmlEPTB;MD65OFg3PSEQvF2= MnO5V2FPT0WU
KURAMOCHI MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTmc4VKSzVyPUCuPVUyQTJizszN M3zwbHNCVkeHUh?=
PA-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHGNI5KSzVyPUCuPVU1OjRizszN NEPEOWJUSU6JRWK=
NOS-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\kOFhKSzVyPUCuPVc1QDlizszN Ml3pV2FPT0WU
NCI-H69 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzITWM2OD1yLkm3OlM1KM7:TR?= MUDTRW5ITVJ?
KYSE-450 M{\lV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjmW4NKSzVyPUCuPVg3OjZizszN MVfTRW5ITVJ?
8505C Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjle2NIUUN3ME2wMlk6QTh{IN88US=> NW\EU|dqW0GQR1XS
TGBC24TKB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFwMECwPFQh|ryP NVnMdGhMW0GQR1XS
PFSK-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W2c2lEPTB;MT6wNVQzQCEQvF2= MUPTRW5ITVJ?
EKVX MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TDPGlEPTB;MT6wN|EzOSEQvF2= NX[w[GF5W0GQR1XS
RCM-1 NYXwXpFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:5TWM2OD1zLkC1OVA4KM7:TR?= MUjTRW5ITVJ?
SW900 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnxVJUzUUN3ME2xMlA4QDNizszN MnGxV2FPT0WU
D-542MG Mm\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnnNpFlUUN3ME2xMlA4QDV3IN88US=> Mn7UV2FPT0WU
SK-PN-DW MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\TOmJKSzVyPUGuNVAxPTZizszN MUPTRW5ITVJ?
NCI-H727 MlvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\SWWlEPTB;MT6xNFE2PCEQvF2= NIPENFNUSU6JRWK=
SW837 MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\RblVEUUN3ME2xMlExQTV2IN88US=> NGT3eZdUSU6JRWK=
BT-20 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTFwMUGyNFQh|ryP M3zkNnNCVkeHUh?=
RH-18 NX3XSmg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT6TWM2OD1zLkGzNVA{KM7:TR?= M2fGUHNCVkeHUh?=
TE-12 NXSxTG9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfOOHNPUUN3ME2xMlE{OzN|IN88US=> MYrTRW5ITVJ?
NB10 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17rOWlEPTB;MT6xN|M1PCEQvF2= NHT4cIFUSU6JRWK=
AU565 NVT6T5FqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vGeWlEPTB;MT6xOVk4OyEQvF2= NGfYNmhUSU6JRWK=
OAW-42 NU\pTGlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3wVIpKSzVyPUGuNVg{ODZizszN NEG3VVZUSU6JRWK=
DJM-1 NV3jR2I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnER|RKSzVyPUGuNVk5QDFizszN Mlj3V2FPT0WU
HH NWDVdFJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjXTWM2OD1zLkKzPFMyKM7:TR?= MlfUV2FPT0WU
LAMA-84 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vlcmlEPTB;MT6yO|M6PCEQvF2= MmnGV2FPT0WU
KNS-42 NVftbVEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfPPFZKSzVyPUGuN|AzQTZizszN NXPsSmVmW0GQR1XS
NCI-H2052 M3K2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\LfWtKSzVyPUGuN|A2ODdizszN MlzUV2FPT0WU
MLMA M1;zU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO5OnVKSzVyPUGuN|I1ODdizszN NWHte2l1W0GQR1XS
NB12 NXP4ZXJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX1N|ZKSzVyPUGuN|U3OzZizszN NHrtc2tUSU6JRWK=
NCI-H1838 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK4b4ltUUN3ME2xMlM3OzB4IN88US=> MlzVV2FPT0WU
NCI-H526 NGLJOGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn75TWM2OD1zLkO3PFU{KM7:TR?= NH3wOIdUSU6JRWK=
LS-123 MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\XNm5zUUN3ME2xMlM6ODl2IN88US=> NG\mT2hUSU6JRWK=
HDLM-2 M3j5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jkOWlEPTB;MT6zPVI4OSEQvF2= NX7wenNqW0GQR1XS
MC-IXC MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwNEKzO|Eh|ryP NHK1TJlUSU6JRWK=
HCT-15 NUnwOohwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4j1VmlEPTB;MT60N|A3QCEQvF2= M{jLNHNCVkeHUh?=
NCI-H596 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXETWM2OD1zLkS1NFYyKM7:TR?= NXvLTVFVW0GQR1XS
ZR-75-30 MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmiwTWM2OD1zLkS3NFgzKM7:TR?= NH24PJFUSU6JRWK=
A704 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;4SmRKSzVyPUGuOlY2PjNizszN NYLNc4JrW0GQR1XS
OVCAR-4 M4D0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTqZ5ZiUUN3ME2xMlY6PjB5IN88US=> MV;TRW5ITVJ?
SW1417 M{XJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi2bGNKSzVyPUGuO|I5PDlizszN MWrTRW5ITVJ?
CAS-1 NGPI[YdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTFwN{O5N|Yh|ryP NIK3UFlUSU6JRWK=
IST-SL1 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnWbmNzUUN3ME2xMlc6PzV7IN88US=> NHnTO2VUSU6JRWK=
A253 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTFwOEKyN|kh|ryP M4GwWXNCVkeHUh?=
EW-16 M{Thd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVL0d4QzUUN3ME2xMlgzQDd3IN88US=> Mm[2V2FPT0WU
SK-NEP-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTFwOE[5PFgh|ryP NUW5OJViW0GQR1XS
NCI-H226 NVTyVnBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXXdppKSzVyPUGuPFk{PTlizszN M1SxbHNCVkeHUh?=
HOP-92 NWLyR4xzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PaRmlEPTB;MT65OlA6QSEQvF2= M2\qSnNCVkeHUh?=
NCI-H441 M{nnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fiSGlEPTB;Mj6wNlM{PyEQvF2= MnjFV2FPT0WU
LU-139 M3T0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrNTWM2OD1{LkCzNVE1KM7:TR?= M1naS3NCVkeHUh?=
SJRH30 M2nPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\JOWlEPTB;Mj6wOFI2OyEQvF2= MkjQV2FPT0WU
MG-63 NXe1N|h6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H5VWlEPTB;Mj6xOFEyOSEQvF2= NETqdVFUSU6JRWK=
NH-12 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfwXXJKSzVyPUKuNVUxODZizszN NEThPHhUSU6JRWK=
NB7 M1jwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJwMUm2O|Mh|ryP NX3MZWllW0GQR1XS
LB771-HNC M{TO[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlznTWM2OD1{LkKwOVk2KM7:TR?= MXXTRW5ITVJ?
HCC1569 M4fXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDRTWM2OD1{LkK0OVg{KM7:TR?= Mn7zV2FPT0WU
D-283MED NGLGOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfLRW5tUUN3ME2yMlI1Pzh{IN88US=> M{fnfnNCVkeHUh?=
J-RT3-T3-5 Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjkZnNKSzVyPUKuNlU{PTFizszN MVnTRW5ITVJ?
ATN-1 NEXDOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC0TWM2OD1{LkOzNFgzKM7:TR?= M3nCRXNCVkeHUh?=
HCC1954 M4D1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXlTWM2OD1{LkO0OFA5KM7:TR?= MUjTRW5ITVJ?
SCC-15 MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJwM{mzNVIh|ryP NFTDWoNUSU6JRWK=
COLO-668 Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;TTWM2OD1{LkSzNkDPxE1? NITEfHdUSU6JRWK=
LB373-MEL-D NITrToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7MeVNEUUN3ME2yMlU1Pjd5IN88US=> NIewS3BUSU6JRWK=
no-10 NW\YOZo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPx[m9uUUN3ME2yMlU1QTR5IN88US=> NXjHdJJbW0GQR1XS
HT-1197 MmPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJwNkOxPFgh|ryP NU\BPW5vW0GQR1XS
DU-145 MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXwUpdNUUN3ME2yMlc6OTZ{IN88US=> MmnJV2FPT0WU
SK-N-AS NXn3RpVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTvPItKSzVyPUKuPFQ3QTJizszN MUnTRW5ITVJ?
MOLT-4 MoHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJwOEWzNlIh|ryP Ml3MV2FPT0WU
EW-22 MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PZOGlEPTB;Mj65Nlg1OSEQvF2= MUPTRW5ITVJ?
DB M4PvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHmxNZpKSzVyPUKuPVc4PTlizszN MkfGV2FPT0WU
HL-60 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfPTWM2OD1|LkC0N|c3KM7:TR?= NHrUbmVUSU6JRWK=
SK-N-DZ Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\BRXRKSzVyPUOuNFUxPzVizszN M{C1cnNCVkeHUh?=
NY MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3WbpBKSzVyPUOuNFg2PDJizszN Mm\HV2FPT0WU
T47D NXXkblFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTNwMUC1OVgh|ryP MlXHV2FPT0WU
NCI-H2029 NFfOZ5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn6yTWM2OD1|LkKyOFc4KM7:TR?= NF7SN5lUSU6JRWK=
KARPAS-299 MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\JZWhOUUN3ME2zMlI3ODJ5IN88US=> MnLwV2FPT0WU
KM-H2 MlfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X4[2lEPTB;Mz6zNFY5KM7:TR?= MVfTRW5ITVJ?
CHP-134 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7JeXZCUUN3ME2zMlQ4OzlizszN NYXZUlBsW0GQR1XS
22RV1 M4DaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\UNmlEPTB;Mz60PVE3QCEQvF2= M4Hs[3NCVkeHUh?=
NB5 NF3UOnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTNwNUC2PFkh|ryP M{T4eXNCVkeHUh?=
CW-2 Ml24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H3dmlEPTB;Mz61OVMyPCEQvF2= MYrTRW5ITVJ?
EFO-21 M{PRSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfpPHRKSzVyPUOuOVY6PCEQvF2= NYm5UIRoW0GQR1XS
HuH-7 NGTXUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTNwNUi0NVQh|ryP NHSxWVFUSU6JRWK=
ALL-PO NX;sN2dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG1b3NKSzVyPUOuOlI{OzVizszN NVG2U3pyW0GQR1XS
EM-2 NHXhNm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn3VG5KSzVyPUOuOlkxOTFizszN MXrTRW5ITVJ?
KLE NV7zO4V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfqZmpKSzVyPUOuO|MxOjlizszN M3L0SHNCVkeHUh?=
NEC8 NYLkOZlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3BNodKSzVyPUOuPVE5ODhizszN MUjTRW5ITVJ?
KP-N-YN MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrvWotKSzVyPUOuPVM1PzZizszN NWDGR21EW0GQR1XS
SK-MEL-1 NVPaOlR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m1[mlEPTB;ND6wN|UyQCEQvF2= MXTTRW5ITVJ?
CAL-54 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXUTWM2OD12LkC1PVEh|ryP MUPTRW5ITVJ?
MS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRwMU[xOVUh|ryP NID0dZJUSU6JRWK=
NCI-H209 NF72b2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjkTWM2OD12LkK5PVk6KM7:TR?= NWjsd3J[W0GQR1XS
NOMO-1 NG\kW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TQTGlEPTB;ND6zNlE{OSEQvF2= MX\TRW5ITVJ?
RPMI-2650 M2q1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DHR2lEPTB;ND6zOlMzPyEQvF2= NGfy[|ZUSU6JRWK=
NCI-H810 M1TGVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTRwM{m3N|Yh|ryP MknJV2FPT0WU
Ca9-22 MmPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknaTWM2OD12LkS1OlkyKM7:TR?= M1z4[HNCVkeHUh?=
ES4 NInwN2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PWTWlEPTB;ND60O|A6PSEQvF2= NIDOcWJUSU6JRWK=
ES6 M4rTVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPifG5KSzVyPUSuOFk3PTdizszN M2PibXNCVkeHUh?=
DMS-114 M3\PdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Xsd2lEPTB;ND61OFY6OSEQvF2= MmTIV2FPT0WU
ONS-76 NIjB[VRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlK4TWM2OD12LkW3PVUh|ryP NH33V4lUSU6JRWK=
K-562 NG\VSHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7FTWM2OD12LkezPFE1KM7:TR?= NXvsRlZKW0GQR1XS
MHH-NB-11 NGjB[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTRwN{W0OlEh|ryP M3KzSXNCVkeHUh?=
Calu-3 NU\J[JFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LDVGlEPTB;ND63PFU1QCEQvF2= NV7xW3pIW0GQR1XS
HT55 MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVS3eoRWUUN3ME20Mlg1PTR3IN88US=> NXLGb4RyW0GQR1XS
SK-N-FI Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHGzTpdKSzVyPUSuPFUxODlizszN NWXqR3pEW0GQR1XS
ES1 NFK5XFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTsc2NKUUN3ME20Mlg3ODV5IN88US=> M4LTSXNCVkeHUh?=
SF126 M{LhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XUR2lEPTB;ND65N|E5PCEQvF2= M4\PO3NCVkeHUh?=
ES5 NHn1ZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTVwMUK0Nlch|ryP M3XJXnNCVkeHUh?=
LoVo MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXRZmU3UUN3ME21MlE2QDdzIN88US=> NWXKeJhnW0GQR1XS
SNU-387 M3WxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXVTWM2OD13LkOyN|M6KM7:TR?= MXHTRW5ITVJ?
C8166 M3m5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37KSWlEPTB;NT6zOlM{QSEQvF2= NHy1UWtUSU6JRWK=
LS-1034 MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1yzPWlEPTB;NT60NlMxPyEQvF2= NGLjdGdUSU6JRWK=
GR-ST M1Thcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;tTWM2OD13LkWyNlAyKM7:TR?= MoPoV2FPT0WU
NCI-H1092 M1W3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz2OnJmUUN3ME21MlczQDR|IN88US=> NIjCRnlUSU6JRWK=
647-V MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDCTWM2OD13Lke0O|A3KM7:TR?= MWDTRW5ITVJ?
EW-13 NIXKNlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojVTWM2OD13Lke2OlI4KM7:TR?= NUDPUph5W0GQR1XS
KGN MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfjeGxQUUN3ME22MlA6QTJzIN88US=> NHvWTWZUSU6JRWK=
D-423MG NULFU2o3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrhN45KSzVyPU[uOFAzQDRizszN MVXTRW5ITVJ?
ECC10 NF3IbZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqzTWM2OD15LkGwNVAyKM7:TR?= NWnCTHdMW0GQR1XS
TE-5 NV63XYxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTdwNEGyPVgh|ryP MY\TRW5ITVJ?
P12-ICHIKAWA M4XPcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGOyNoNKSzVyPUeuOFU2OjNizszN MWfTRW5ITVJ?
NCI-H82 M4nib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvoTWM2OD15LkS1O|AyKM7:TR?= MXHTRW5ITVJ?
NCI-H1993 NV\pbpJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjXdYY6UUN3ME23Mlg{ODZ|IN88US=> M{C3XHNCVkeHUh?=
RH-1 NGXFeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTdwOEWyOFQh|ryP NHzSSG1USU6JRWK=
SW948 M4nFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:1TWM2OD15Lkm2NFQ6KM7:TR?= MmPFV2FPT0WU
CAL-33 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDKOGZKSzVyPUeuPVk6OzhizszN MoK4V2FPT0WU
U-266 NV\ON3k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRThwMUW3O|ch|ryP MlHGV2FPT0WU
CAL-72 NY\KPHdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHTXIpKSzVyPUiuNlA{OiEQvF2= NVf1cZZCW0GQR1XS
SNU-423 NGPabYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1GwbWlEPTB;OT6zOlY3PiEQvF2= M{fzS3NCVkeHUh?=
KG-1 NGLrW3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLNVFJ1UUN3ME25MlU5PDV4IN88US=> NILXSFdUSU6JRWK=
HCC1395 MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTlwOUKzOVIh|ryP NUPwZW1SW0GQR1XS
BE-13 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFyLki4PVIh|ryP NYTZNYhJW0GQR1XS
MKN7 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjR[JNKUUN3ME2xNE46PzZ3IN88US=> M4TkenNCVkeHUh?=
697 M2X4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLiTWM2OD1zMT6xOFczKM7:TR?= MUPTRW5ITVJ?
LU-135 NV63flBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDLTWM2OD1zMT6yN|A4KM7:TR?= MUnTRW5ITVJ?
ES7 MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFzLkOzNVMh|ryP NYe4e3JwW0GQR1XS
SK-HEP-1 NImwOIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzNTWM2OD1zMT63OlQ3KM7:TR?= NH;GNZVUSU6JRWK=
BEN MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFzLki1NUDPxE1? MVvTRW5ITVJ?
NCI-H1770 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M163OmlEPTB;MUKuNVI3KM7:TR?= NH7SW5VUSU6JRWK=
SW13 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF{LkG1OFEh|ryP MkLhV2FPT0WU
MZ1-PC MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPDeXhSUUN3ME2xNk42PDV{IN88US=> MVrTRW5ITVJ?
Mo-T MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrQTWM2OD1zMj63OFIyKM7:TR?= M2\zdXNCVkeHUh?=
HLE NYm0foVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzRR|lKSzVyPUGyMlgzOTVizszN M{PHUXNCVkeHUh?=
RCC10RGB Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHyUpNCUUN3ME2xN{43PzFizszN MXnTRW5ITVJ?
COLO-320-HSR MmW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\0RmlEPTB;MUOuO|M5OSEQvF2= NYHYTm5MW0GQR1XS
BHT-101 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X0XWlEPTB;MUOuPFM1PSEQvF2= MXjTRW5ITVJ?
OCUB-M MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL3TWM2OD1zND6xOlAzKM7:TR?= NGjuS2xUSU6JRWK=
MEG-01 M3jXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPqTWM2OD1zND6zO|A5KM7:TR?= MVnTRW5ITVJ?
RS4-11 NXTQNGhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nmNWlEPTB;MUSuO|QzKM7:TR?= NVTyc4dPW0GQR1XS
MN-60 M2\vZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH5b2tKSzVyPUG0Mlc5QTRizszN M3ezWXNCVkeHUh?=
NCI-H1304 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7aTWM2OD1zNT6wOFI2KM7:TR?= NH\p[mZUSU6JRWK=
Ramos-2G6-4C10 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q5OGlEPTB;MUWuNFU5OSEQvF2= MlXMV2FPT0WU
NCI-H2342 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TXZ2lEPTB;MUWuNlA1PCEQvF2= NEPCbVJUSU6JRWK=
LAN-6 MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\VTGlqUUN3ME2xOU41PDF2IN88US=> NXyze3c4W0GQR1XS
JVM-2 NVTDZXVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF3LkW3OFgh|ryP NIjU[W5USU6JRWK=
P30-OHK MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TRTWlEPTB;MU[uNFYyPCEQvF2= NW\sWXpjW0GQR1XS
C-33-A M4H4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnVNpluUUN3ME2xOk43OjF2IN88US=> MVnTRW5ITVJ?
RPMI-8866 NYrzVpR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;wW|dKSzVyPUG2Mlg1QTZizszN MVPTRW5ITVJ?
NCI-H630 M2i3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTF4Lki1N|ch|ryP NFnQSZFUSU6JRWK=
KYSE-140 NHPTc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTF5LkKwNlgh|ryP M1jDZ3NCVkeHUh?=
T84 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G0[mlEPTB;MUiuPFY6PSEQvF2= MWPTRW5ITVJ?
KU-19-19 M2fsVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTF6Lkm2NFgh|ryP NVLsTXVUW0GQR1XS
BALL-1 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF7LkOzPVkh|ryP MYDTRW5ITVJ?
Calu-6 MljvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTXTWM2OD1zOT60PVIh|ryP MU\TRW5ITVJ?
EGI-1 NYXPephLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTYTWM2OD1zOT61PVgh|ryP MnPxV2FPT0WU
MFH-ino M17POWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT0R3NKSzVyPUG5Mlc1PTRizszN NW\BXVVLW0GQR1XS
GB-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDHeIlKSzVyPUKwMlM2OzVizszN NWj4bJZpW0GQR1XS
NCI-H1693 NXzMOVRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j2WWlEPTB;MkCuOlUxPSEQvF2= M4TMN3NCVkeHUh?=
SW1116 MmHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PVOGlEPTB;MkCuPVM3OiEQvF2= MVHTRW5ITVJ?
H-EMC-SS M2\Ud2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFuyRlhKSzVyPUKyMlA1PSEQvF2= MkTSV2FPT0WU
D-502MG Mm\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LrVmlEPTB;MkKuPFI3OSEQvF2= Mn34V2FPT0WU
IA-LM NHLVe5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPId2NKSzVyPUKzMlI1QTNizszN NGjjbVNUSU6JRWK=
SW1463 MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W0e2lEPTB;MkOuO|kh|ryP NU\LT3F4W0GQR1XS
JAR MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXQTWM2OD1{ND6zNlk{KM7:TR?= NFnHNpJUSU6JRWK=
HT NVTteXNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fuUWlEPTB;MkSuOFc2OyEQvF2= M1HoPHNCVkeHUh?=
LCLC-103H Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJ2Lki0OFkh|ryP NYK1cHdYW0GQR1XS
SNU-449 MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX6[GJKSzVyPUK0Mlg4PDFizszN NELZPZBUSU6JRWK=
KE-37 NGrwZ2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn2dmF2UUN3ME2yOU4xQTJ6IN88US=> NX;ETYFKW0GQR1XS
NCI-H1623 M2XQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHvTWM2OD1{Nz6xN|A{KM7:TR?= M3ntO3NCVkeHUh?=
MOLT-13 NVXNUpJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPQTWM2OD1{Nz6zOVE3KM7:TR?= NV7KOXZQW0GQR1XS
COLO-741 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LRe2lEPTB;M{GuN|M{OyEQvF2= NYrZdHRvW0GQR1XS
NB6 NGPUWYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLER5VSUUN3ME2zNk4zQDd4IN88US=> MmHPV2FPT0WU
MOLT-16 NYXDXmFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr2b4JKSzVyPUOzMlAxPTVizszN MUnTRW5ITVJ?
IST-MES1 NUPGeohMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTN2LkC1OFEh|ryP MWDTRW5ITVJ?
A4-Fuk NFHHVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDSTWM2OD1|NT6wOlYh|ryP M2fDTXNCVkeHUh?=
CAL-85-1 MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nSb2lEPTB;M{WuNlgyPyEQvF2= Mkn1V2FPT0WU
CCRF-CEM M3PCXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTN5LkG1N|Yh|ryP NFrhb3JUSU6JRWK=
HAL-01 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW0[m0{UUN3ME2zPE41QDh7IN88US=> MmewV2FPT0WU
HEL MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrXc2xKSzVyPUSzMlM1ODlizszN NI\idpVUSU6JRWK=
EW-1 NULyRmtnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDQZplrUUN3ME20N{41PzZ6IN88US=> MnyyV2FPT0WU
MDA-MB-231 MnXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTR3LkGxPVkh|ryP MWTTRW5ITVJ?
ABC-1 MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrMXldKSzVyPUS2Mlg2OzhizszN NEj2dWNUSU6JRWK=
NCI-H446 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTR6LkWwOVgh|ryP MmnGV2FPT0WU
MHH-PREB-1 MlPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX64VnZxUUN3ME20PU43ODB5IN88US=> MVzTRW5ITVJ?
DOHH-2 M3rWS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnj0TWM2OD12OT62OlU3KM7:TR?= M1jEbnNCVkeHUh?=
GCT NIDXW5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHm4eFdKSzVyPUS5MlY6PzZizszN MV7TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]
臨床試験 A Phase II study of 17-AAG in patients with relapsed/refractory CD30 plus anaplastic large cell lymphoma (ALCL) relapsed/refractory mantle cell lymphoma (MCL) and relapsed/refractory classical Hodgkin's lymphoma (HL) has been completed.
特集 Displays very low toxicity toward normal cells.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Hsp90 binding assays Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.

細胞アッセイ: [1]

細胞株 BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 5 days
実験の流れ Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.

動物実験: [2]

動物モデル Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
製剤 Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
投薬量 ~50 mg/kg
投与方法 Injection i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download 17-AAG (Tanespimycin) SDF
分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管 2年-20℃
6月-80℃in solvent
別名 CP127374,NSC-330507, KOS 953
溶解度 (25°C) * In vitro DMSO 100 mg/mL (170.73 mM)
エタノール 5 mg/mL (8.53 mM)
<1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 17-demethoxy-17-(2-propenylamino)- [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

カスタマーフィードバック (7)


Click to enlarge
Rating
Source , , PNAS, 2011, 108: 7535-40. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines H3122 & H3122 CR cells
Concentrations 10 nM
Incubation Time 72 h
Results As shown in Fig. A, 17-AAG potently suppressed cell growth in both parental H3122 and H3122 CR cells. However, in contrast to NVP-TAE684 and AP26113, 17-AAG also inhibited the viability of SKBR3 and BT474 cell lines. 17-AAG treatment decreased both p-ALK 眏Ỵ眐㠞眎膉癠 皐﷘ř᐀ŔřĀ 㺣癞帉癞Ѐ瑖兽ﱔᆊࣿřĀࣾ彿兾奋兾巫兾婶ࣿ橢ࣿ彿兾

Click to enlarge
Rating
Source Oncotarget, 2014, 5, 4269-82. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines Ls-174T, HCT116, Caco2, Hke3 cells
Concentrations 0.5, 2 uM
Incubation Time 24 h
Results Colon cancer cells harboring WT or MT K-Ras were treated with 17-AAG and effects on the Ras expression were analyzed by WB. Results in Figure showed that incubation with 17-AAG only down-regulates K-Ras in K-Ras MT cells but decreases Raf-1 {an established Hsp90 client} in all cell lines. The result, for the first time, demonstrated that both transfected and endogenous MT K-Ras is an Hsp90 client protein.

Click to enlarge
Rating
Source Oncotarget, 2015, 51: S659-S660. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines MOLT-4 & RS4;11 cells
Concentrations
Incubation Time 22 h
Results In both MOLT-4 and RS4;11 cells, the combined treatment inhibited the interactions between Hsp90 and BIP/Grp78 more effectively than CX-4945 single treatment and to the same extent as tanespimycin (17-AAG).

Click to enlarge
Rating
Source Mol Cell Biol, 2013, 33(12), 2375-87. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines NIH 3T3 cells
Concentrations 25, 50 uM
Incubation Time 4 h
Results 17-AAG and SNX-2112, both of which induce the UPR by targeting the chaperone HSP90, decreased mSmoM2 protein levels (lanes 2 to 5 compared to lane 1), further supporting the sensitivity of active Smo mutants to UPR induction.

Click to enlarge
Rating
Source J Biol Chem, 2012, 287, 44109-20. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines Dopaminergic Neuronal Cell lines
Concentrations 10-20uM
Incubation Time
Results As expected, both complex IV activity and Hsp60 levels exhibited a dose-dependent decrease in response to treatment with 17-AAG (Fig. 4A). However, 17-AAG treatment did not alter levels of Hsp90 and LRPPRC levels

Click to enlarge
Rating
Source Mol Cancer, 2014, 13, 150. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines SKBR3 cells
Concentrations 1, 2 uM
Incubation Time 24 h
Results Hsp90 and Cdc37 protein levels showed no distinct change according to a drug concentration gradient, whereas Hsp70, a marker of Hsp90 inhibition, the protein level was greatly induced by treatment with 17AAG or FW-04-806.

Click to enlarge
Rating
Source Age, 2013, 35, 549-62. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines HFSN1 cells
Concentrations 0.1/0.5uM
Incubation Time 24 h
Results Figure 2c shows that the decrease in the level of Hsp90 after treatment with 0.5 μM of 17-AAG was accompanied by a decrease in the level of both the survivin and phospho-survivin proteins.

文献中の引用 (19)

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

電話番号: +1-832-582-8158 Ext:3月曜日〜金曜日 9:00 AM–5:00 PM (米国中部標準時)

他の質問がある場合は、お気軽くお問合せください。

* 必須

Related HSP (e.g. HSP90) 阻害剤

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.

  • KNK437

    KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

  • VER155008

    VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

  • FRAX597

    FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.

  • Luminespib (AUY-922, NVP-AUY922)

    Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090)は独特な triazolone-containing Hsp90阻害剤、 IC50 が4 nM となる.

  • 17-DMAG (Alvespimycin) HCl

    17-DMAG (Alvespimycin) HClは、62nMのIC50による強力なHsp90阻害剤です。

    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    ノーカット二量体Hsp90またはN末端領域Hsp90と結合している間、Geldanamycinは1.2のμMまたは0.78のμMによるKdによる天然既存のHsp90阻害剤です。

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

最近チェックしたアイテム

Tags: 17-AAG (Tanespimycin)を買う | 17-AAG (Tanespimycin)供給者 | 17-AAG (Tanespimycin)を購入する | 17-AAG (Tanespimycin)費用 | 17-AAG (Tanespimycin)生産者 | オーダー17-AAG (Tanespimycin) | 17-AAG (Tanespimycin)代理店
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
お問い合わせ