17-AAG (Tanespimycin) 化学構造
分子量: 585.69

高品質保証

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製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 17-AAG (Tanespimycin)は、5nMのIC50による強力な熱ショックタンパク質90(Hsp90)阻害剤です。
ターゲット HSP90
IC50 5 nM [1]
In vitro試験 17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A549 Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H6V2lEPTB;MD6wNFA{ODNizszN NUnsSIt5W0GQR1XS
IST-MEL1 M3LOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHNOYNDUUN3ME2wMlAxODRyNzFOwG0> NGnz[4FUSU6JRWK=
NCI-SNU-1 M2f2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLKTWM2OD1yLkCwNlA4KM7:TR?= MWfTRW5ITVJ?
FADU NHvqfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPFXWxKSzVyPUCuNFAzODlizszN MXvTRW5ITVJ?
C32 NUfUWGFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMECzNFQh|ryP NYrSWVR1W0GQR1XS
D-566MG NUjNNng1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMECzPUDPxE1? M{HubXNCVkeHUh?=
LXF-289 MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjSVoxKSzVyPUCuNFA1OTlizszN MlmxV2FPT0WU
HGC-27 NG\hdWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofPTWM2OD1yLkCwOVEh|ryP M4W4ZXNCVkeHUh?=
RPMI-7951 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfwTWM2OD1yLkCwO|E4KM7:TR?= M2fG[HNCVkeHUh?=
HSC-3 NGLQSFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj1TWM2OD1yLkCwPVI6KM7:TR?= MU\TRW5ITVJ?
MIA-PaCa-2 M3vGbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEGwNFkh|ryP MkLPV2FPT0WU
KS-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEGzOVUh|ryP Mnv1V2FPT0WU
CAL-51 MofTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NICwSGVKSzVyPUCuNFE1ODVizszN M2LrWnNCVkeHUh?=
MDA-MB-361 NFvaR|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPPW4NrUUN3ME2wMlAyPDl3IN88US=> MljBV2FPT0WU
TI-73 NGf2dYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHftXYhKSzVyPUCuNFE4QTZizszN M4DSW3NCVkeHUh?=
AGS NEfFfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjKb2FKSzVyPUCuNFE6OzhizszN M4P0V3NCVkeHUh?=
NCI-H460 M4GxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzDTWNKSzVyPUCuNFE6PzRizszN NXWwN2hYW0GQR1XS
A204 M4jwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEKyOFkh|ryP MV\TRW5ITVJ?
CHL-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEKyOVEh|ryP MY\TRW5ITVJ?
DU-4475 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mof5TWM2OD1yLkCyNlYyKM7:TR?= M{PVUHNCVkeHUh?=
CGTH-W-1 M1TSZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy1WZEzUUN3ME2wMlAzOzR7IN88US=> MXTTRW5ITVJ?
HCC2218 NXzDbHljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG2TWM2OD1yLkCyOFk1KM7:TR?= NI\3RVdUSU6JRWK=
A2780 NGS2S|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEK1N|Eh|ryP Mnz1V2FPT0WU
NCI-H720 M{npeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLxfWN{UUN3ME2wMlAzPTR4IN88US=> Ml\MV2FPT0WU
NCI-N87 MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm2cXFIUUN3ME2wMlAzPTl|IN88US=> MlLGV2FPT0WU
CHP-212 M3fPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13TTWlEPTB;MD6wNlYzQCEQvF2= Ml22V2FPT0WU
NCI-H23 MmDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjwTWM2OD1yLkCyOlY2KM7:TR?= MXnTRW5ITVJ?
D-263MG MlfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTKTWM2OD1yLkCyO|g3KM7:TR?= Ml;GV2FPT0WU
ME-180 M4LCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\aTWM2OD1yLkCyPFkyKM7:TR?= NYT3NmxuW0GQR1XS
SW982 MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMEK5PVkh|ryP MlXLV2FPT0WU
OE19 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TBbWlEPTB;MD6wN|A4PyEQvF2= Mn3QV2FPT0WU
SK-LU-1 NGq0O49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDwfohKSzVyPUCuNFMxQDJizszN NF3pbWZUSU6JRWK=
H4 NGG4TFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLUO2xOUUN3ME2wMlA{ODlizszN NHzBWmlUSU6JRWK=
HT-144 M4XFdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnKXlA{UUN3ME2wMlA{ODl|IN88US=> M4DLT3NCVkeHUh?=
SK-UT-1 NVS3fGRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjDVXJKSzVyPUCuNFMyPzhizszN NEK3bItUSU6JRWK=
D-336MG MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnPbItKSzVyPUCuNFM{ODlizszN M2TqWHNCVkeHUh?=
MDA-MB-175-VII MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIewRnFKSzVyPUCuNFM{PTRizszN MnvTV2FPT0WU
GAMG MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXP[WxwUUN3ME2wMlA{PDN3IN88US=> NILBb5hUSU6JRWK=
CP50-MEL-B Mo\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDqTG9KSzVyPUCuNFM1PSEQvF2= NFnPeFZUSU6JRWK=
OVCAR-5 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33RUGlEPTB;MD6wN|Q5KM7:TR?= NEjxTmpUSU6JRWK=
SK-MES-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r4[WlEPTB;MD6wN|YxPiEQvF2= Mm[3V2FPT0WU
VM-CUB-1 M2TSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEO2OVch|ryP MXTTRW5ITVJ?
WM-115 NXfLWXlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TZe2lEPTB;MD6wN|c3OiEQvF2= M2\pN3NCVkeHUh?=
DSH1 M2rPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDuWVJsUUN3ME2wMlA{QDB5IN88US=> NFe3T4NUSU6JRWK=
Becker M{C5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEO4PFUh|ryP NELGd3NUSU6JRWK=
SW962 MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEO5OFUh|ryP NFnoTJRUSU6JRWK=
TYK-nu NYXzXmp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLGOldKSzVyPUCuNFM6QDVizszN MVfTRW5ITVJ?
HO-1-N-1 M3Xzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nPXmlEPTB;MD6wOFAzOSEQvF2= M2rYcHNCVkeHUh?=
T98G MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7hZnRKSzVyPUCuNFQyODNizszN M1j2OHNCVkeHUh?=
ACN Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7lWJJKSzVyPUCuNFQyPjJizszN MXTTRW5ITVJ?
SW780 M37zVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX1WG02UUN3ME2wMlA1OjB|IN88US=> M3HL[XNCVkeHUh?=
Detroit562 NWXaWWJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLXTWM2OD1yLkC0NlM6KM7:TR?= MVLTRW5ITVJ?
BB49-HNC NV\rTVBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHWSYRoUUN3ME2wMlA1OjR|IN88US=> NIPibYVUSU6JRWK=
HN NHLMWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMESyO|Ih|ryP MmLOV2FPT0WU
H9 NVPVVYpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTzbI5KSzVyPUCuNFQ{PzFizszN M1izeHNCVkeHUh?=
VA-ES-BJ M{\Ocmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\XS|ZKSzVyPUCuNFQ1PDdizszN MUHTRW5ITVJ?
MEL-JUSO NWnWWVh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLRUHVWUUN3ME2wMlA1PDd3IN88US=> MoK0V2FPT0WU
BT-474 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELqcnhKSzVyPUCuNFQ2KM7:TR?= MkLwV2FPT0WU
CaR-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PWNGlEPTB;MD6wOFU1QSEQvF2= MlvZV2FPT0WU
PSN1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzCV5BjUUN3ME2wMlA1PjB|IN88US=> NITzfnlUSU6JRWK=
KYSE-510 NF[ySm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DLdGlEPTB;MD6wOFY1QSEQvF2= M4W1UnNCVkeHUh?=
KP-4 M2fRR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMES3OVMh|ryP NWHjTJFLW0GQR1XS
KYSE-410 NIjkNpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWexU|htUUN3ME2wMlA1Pzd{IN88US=> M3Pn[3NCVkeHUh?=
G-402 NIXrNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFKxWlJKSzVyPUCuNFQ4QDlizszN NV3WUGdqW0GQR1XS
DOK M1nLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT1dpd[UUN3ME2wMlA1QTB{IN88US=> M{XUOXNCVkeHUh?=
COR-L88 MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMES5NVIh|ryP NHz0coFUSU6JRWK=
SKG-IIIa NXr4UWViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDFbpV2UUN3ME2wMlA1QTh4IN88US=> NF\XWnlUSU6JRWK=
AN3-CA MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rFTGlEPTB;MD6wOUDPxE1? MoHPV2FPT0WU
SW48 NUTre|A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEToVIlKSzVyPUCuNFUxOzlizszN NFXHNnlUSU6JRWK=
YKG-1 NUj2OppiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEWwO|Eh|ryP MoCzV2FPT0WU
KYSE-150 NGS5bJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTLbm9zUUN3ME2wMlA2OjN3IN88US=> MoKwV2FPT0WU
HuO-3N1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H3NGlEPTB;MD6wOVI{PyEQvF2= NILWXFBUSU6JRWK=
LB1047-RCC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXiTWM2OD1yLkC1Nlk3KM7:TR?= M1zMb3NCVkeHUh?=
NCI-H2030 MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nr[WlEPTB;MD6wOVQyPCEQvF2= MoPuV2FPT0WU
YH-13 NFrlPItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HQSWlEPTB;MD6wOVczOiEQvF2= MYTTRW5ITVJ?
5637 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTWd2FwUUN3ME2wMlA2PzRizszN NWn5eldUW0GQR1XS
LOXIMVI NX72dW5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[0OHZKSzVyPUCuNFU5PzJizszN NUXFUWNQW0GQR1XS
GT3TKB M{PoOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3uPWVKSzVyPUCuNFU6PDJizszN MX;TRW5ITVJ?
TCCSUP NGnYNGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXsPXpKSzVyPUCuNFU6PjRizszN NUXxcWZDW0GQR1XS
EPLC-272H M1\qbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfCfmsyUUN3ME2wMlA3OjB3IN88US=> NHHvbpNUSU6JRWK=
LU-99A M{jBbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfpemRWUUN3ME2wMlA3OjN5IN88US=> MU\TRW5ITVJ?
NCI-H1755 NFzGNJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\2TWM2OD1yLkC2N|QyKM7:TR?= MU\TRW5ITVJ?
KM12 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwME[zOFgh|ryP NVjWPY9vW0GQR1XS
SF295 Mke2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;aTWM2OD1yLkC2OFUzKM7:TR?= Mo\WV2FPT0WU
MZ2-MEL Ml\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwME[1OVMh|ryP MVvTRW5ITVJ?
HEC-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4KyfWlEPTB;MD6wOlU5QCEQvF2= MoC5V2FPT0WU
SW684 Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PxeWlEPTB;MD6wOlU6OSEQvF2= NWrjdG5jW0GQR1XS
SF539 NYDJR5VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jT[GlEPTB;MD6wOlY5OSEQvF2= M1vsenNCVkeHUh?=
GMS-10 M2rrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmyTWM2OD1yLkC2Olk6KM7:TR?= NXH0UmI6W0GQR1XS
MV-4-11 M4ToPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nv[mlEPTB;MD6wOlgxOyEQvF2= NWi5XXdYW0GQR1XS
HT-29 NIfuW5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwME[5NVkh|ryP M3u0WXNCVkeHUh?=
23132-87 M1qyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmX6TWM2OD1yLkC2PVUh|ryP Mn35V2FPT0WU
SW620 M4jSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITudHNKSzVyPUCuNFcxOjZizszN NHzxdGtUSU6JRWK=
HCC1806 NH23d3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMEexN|Eh|ryP Mo\hV2FPT0WU
Hs-578-T NXLwXo1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmxW4Y6UUN3ME2wMlA4OjB6IN88US=> M{jpVXNCVkeHUh?=
A2058 NUfKfINmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMEeyNlgh|ryP MnG0V2FPT0WU
MEL-HO MoS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjM[ZRZUUN3ME2wMlA4OjV3IN88US=> NWDVXll{W0GQR1XS
HCC2998 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEO2cXVKSzVyPUCuNFc{PDdizszN MVjTRW5ITVJ?
HuO9 NXjNS3JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXDcmFRUUN3ME2wMlA4PTh7IN88US=> M1\MXnNCVkeHUh?=
CAL-39 M1;RN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nQO2lEPTB;MD6wO|c3PiEQvF2= M1PKZXNCVkeHUh?=
M14 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnJTWM2OD1yLkC3PVE{KM7:TR?= MoPkV2FPT0WU
BFTC-909 NXi4[25YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEe5Olkh|ryP MlvyV2FPT0WU
TE-11 M2fsNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEe5PVYh|ryP MWrTRW5ITVJ?
TGBC1TKB MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMEiwOFMh|ryP NEGyPHpUSU6JRWK=
L-363 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYradYwxUUN3ME2wMlA5OjB4IN88US=> MmHnV2FPT0WU
A431 NWPoPW1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X4cWlEPTB;MD6wPFIyKM7:TR?= NX6wXG56W0GQR1XS
MKN45 M1LTTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofxTWM2OD1yLkC4NlE6KM7:TR?= NFjlXWdUSU6JRWK=
HT-1080 NHWzNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:3VWlEPTB;MD6wPFQ{QSEQvF2= MUPTRW5ITVJ?
OVCAR-8 NEToUIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m0UmlEPTB;MD6wPFYzOiEQvF2= MULTRW5ITVJ?
LCLC-97TM1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\CXlk3UUN3ME2wMlA5PzJ6IN88US=> MmL0V2FPT0WU
M059J NGmwXW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\WNmlEPTB;MD6wPVAzPyEQvF2= NVvTWY5SW0GQR1XS
SK-MEL-2 M4W1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrofWV1UUN3ME2wMlA6ODZizszN NHexeplUSU6JRWK=
TE-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fLU2lEPTB;MD6wPVIxPCEQvF2= NYXVbXZzW0GQR1XS
KYSE-180 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD2SYxKSzVyPUCuNFkzPjJizszN NFPkWG1USU6JRWK=
D-247MG NF;F[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEm0OVUh|ryP M1jWfnNCVkeHUh?=
8-MG-BA Mlz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfsNHNKSzVyPUCuNFk1PzJizszN MUPTRW5ITVJ?
NCI-H1792 MmLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfETWM2OD1yLkC5OlE5KM7:TR?= MmDzV2FPT0WU
MCF7 NXHGPZdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvx[VNKSzVyPUCuNFk3PzdizszN M2HNbHNCVkeHUh?=
NCI-H2122 M4DHemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnyTWM2OD1yLkC5O|Q2KM7:TR?= MXrTRW5ITVJ?
EFO-27 NG[xTGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEm5PVch|ryP NYezWXRJW0GQR1XS
LB2241-RCC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLaTWM2OD1yLkGwNFU1KM7:TR?= NG\wWmNUSU6JRWK=
SN12C NXnv[2o4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMUCxNFch|ryP M13jVnNCVkeHUh?=
A498 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUCxPEDPxE1? MlWzV2FPT0WU
PANC-03-27 NUDIU3llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLoNVJKSzVyPUCuNVAzQDZizszN M{PYSHNCVkeHUh?=
NCI-H1581 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDObYxwUUN3ME2wMlExOjlizszN MoryV2FPT0WU
U-87-MG M1TsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q2bWlEPTB;MD6xNFMxPyEQvF2= NWDkNlhjW0GQR1XS
G-401 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj4TWM2OD1yLkGwN|U{KM7:TR?= MXHTRW5ITVJ?
SiHa MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFP1NFJKSzVyPUCuNVA1QDZizszN MXPTRW5ITVJ?
U251 M{nDOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\jTWM2OD1yLkGwOVI2KM7:TR?= Ml:wV2FPT0WU
MMAC-SF MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMUC1N|Eh|ryP MonuV2FPT0WU
BB65-RCC M3zUPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMUC1OVQh|ryP MX3TRW5ITVJ?
NKM-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMUC2OlYh|ryP MofFV2FPT0WU
HD-MY-Z MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TKXWlEPTB;MD6xNFg4OyEQvF2= MV3TRW5ITVJ?
TGBC11TKB NXO1NWF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\uTmlEPTB;MD6xNFkxOyEQvF2= MWjTRW5ITVJ?
COLO-679 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv0c5JKSzVyPUCuNVEzOTFizszN MXjTRW5ITVJ?
TE-8 NYjoc4RwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMUGyOlQh|ryP M1jZenNCVkeHUh?=
SK-MEL-28 Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHKXZZKSzVyPUCuNVE{OjFizszN M4nUWnNCVkeHUh?=
SH-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTTPGFvUUN3ME2wMlEyOzV4IN88US=> NGPuVJNUSU6JRWK=
KALS-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT5TWM2OD1yLkGxN|k{KM7:TR?= NWThWW9pW0GQR1XS
RKO NFfOUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzITWM2OD1yLkGxO|Y1KM7:TR?= NFjJd2JUSU6JRWK=
OMC-1 MmHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMUG3PVch|ryP Mlq0V2FPT0WU
BT-549 NGTJVGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu5WpVKSzVyPUCuNVE4QTlizszN M{LhZ3NCVkeHUh?=
NCI-H28 MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLiVWdtUUN3ME2wMlEyQDF5IN88US=> NFeyXI9USU6JRWK=
RXF393 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HocGlEPTB;MD6xNVk5OiEQvF2= Mni2V2FPT0WU
COLO-829 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUKwNFUh|ryP NUTBOJY2W0GQR1XS
HMV-II M1L0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMUKwNkDPxE1? M{DseHNCVkeHUh?=
SW1990 NHj5enpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly4TWM2OD1yLkGyNVU4KM7:TR?= M17hdXNCVkeHUh?=
NCI-H1437 MoD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TRTWlEPTB;MD6xNlE2PyEQvF2= M{iyfXNCVkeHUh?=
SNB75 MoCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Dj[2lEPTB;MD6xNlE3QSEQvF2= M3\SeHNCVkeHUh?=
EW-3 MoLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH3TYpKSzVyPUCuNVI3PjFizszN NYjoc5I2W0GQR1XS
SAS M1Taemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrjTWM2OD1yLkGyOlkh|ryP NYrrZ|ZrW0GQR1XS
NCI-H1666 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3NdnpXUUN3ME2wMlEzPzd2IN88US=> NWLmOVgyW0GQR1XS
A375 MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMUK3O|gh|ryP MVTTRW5ITVJ?
CAMA-1 NGruSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMUK5NlQh|ryP MWjTRW5ITVJ?
HuP-T4 NFqzd3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMUK5OFMh|ryP MU\TRW5ITVJ?
NCI-H292 NGTmW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnIfmh3UUN3ME2wMlE{OTFizszN MVrTRW5ITVJ?
PC-14 NV3pVY5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPoTWM2OD1yLkGzNlEyKM7:TR?= M3PqenNCVkeHUh?=
BPH-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\XXpBKSzVyPUCuNVM1OSEQvF2= MXTTRW5ITVJ?
GAK MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvX[5BVUUN3ME2wMlE{PTZ5IN88US=> MULTRW5ITVJ?
VMRC-RCZ M13Vd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMUO3OlIh|ryP NGXmVYJUSU6JRWK=
SK-MEL-24 M33LTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP6dYNKSzVyPUCuNVM5PyEQvF2= NFnk[VNUSU6JRWK=
LB831-BLC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L6TGlEPTB;MD6xN|g5OyEQvF2= MlTmV2FPT0WU
NCI-H2452 M2n3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMUO5OVYh|ryP NWrVUW0zW0GQR1XS
RT-112 NF7WXVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMUSwN|Uh|ryP M{\2[XNCVkeHUh?=
GP5d NGjmU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn20TWM2OD1yLkG0NVA1KM7:TR?= NULIW5dWW0GQR1XS
LC-2-ad MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTyTWM2OD1yLkG0NVIyKM7:TR?= NUDHWYRpW0GQR1XS
MPP-89 NGPRT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMUSxNlUh|ryP MYrTRW5ITVJ?
NUGC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfIUmVKSzVyPUCuNVQ1PzhizszN MkezV2FPT0WU
GI-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NES3cFlKSzVyPUCuNVQ2PThizszN NX7RV4tZW0GQR1XS
HCC1419 NHnSN2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnPSJpCUUN3ME2wMlE1PTd4IN88US=> Mo\3V2FPT0WU
SW1573 M3riW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMUS3OVgh|ryP MWTTRW5ITVJ?
NCI-H2347 MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnGcmpJUUN3ME2wMlE1QDN7IN88US=> NGXnNFJUSU6JRWK=
Mewo M1jmZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXCTWM2OD1yLkG0PFg6KM7:TR?= MoX4V2FPT0WU
639-V MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD1RYpvUUN3ME2wMlE2ODF|IN88US=> NIDLTXZUSU6JRWK=
AsPC-1 NG\Yd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMUWyNlUh|ryP NWrzOmFIW0GQR1XS
NCI-H1648 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjxTWM2OD1yLkG1NlMzKM7:TR?= MlrYV2FPT0WU
786-0 NWnoTFZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPFTWM2OD1yLkG1N|gyKM7:TR?= MmTJV2FPT0WU
ETK-1 Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFf0boFKSzVyPUCuNVU6KM7:TR?= MWXTRW5ITVJ?
BxPC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fUVmlEPTB;MD6xOVk3PiEQvF2= MmDKV2FPT0WU
CAL-62 NF3pdnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLUTWM2OD1yLkG2NVY6KM7:TR?= MVTTRW5ITVJ?
HCC1937 MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMU[yO|Uh|ryP MnvZV2FPT0WU
NCI-H1299 NGSwN5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfLN2s5UUN3ME2wMlE3Ojh3IN88US=> NVTjcYdJW0GQR1XS
SW1088 NUHPUWg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Lme2lEPTB;MD6xOlQyOyEQvF2= NX76b5c2W0GQR1XS
FTC-133 MofpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjITWM2OD1yLkG2OVQh|ryP M3\0[3NCVkeHUh?=
OC-314 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e0Z2lEPTB;MD6xOlY6KM7:TR?= MUDTRW5ITVJ?
SCC-9 NUXGOoRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPmZWgzUUN3ME2wMlE3PzF4IN88US=> MV7TRW5ITVJ?
HT-1376 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37Cd2lEPTB;MD6xOlk{PiEQvF2= MorPV2FPT0WU
U-2-OS MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7KXnhKSzVyPUCuNVcyPzNizszN MkfRV2FPT0WU
COLO-824 M{TLSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfZTWM2OD1yLkG3Nlk1KM7:TR?= NV72bGJ5W0GQR1XS
BB30-HNC MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TBVWlEPTB;MD6xO|M{KM7:TR?= NIfsNVJUSU6JRWK=
NCI-H2087 NI\KXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP2eHdKSzVyPUCuNVc{PjhizszN MUPTRW5ITVJ?
NCI-H2170 M2DOWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMUe1N|Yh|ryP M3nROXNCVkeHUh?=
SK-OV-3 NUixOW9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLWTWM2OD1yLkG3OVcyKM7:TR?= NFj3S|BUSU6JRWK=
MZ7-mel NV21UFV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7lTplKSzVyPUCuNVc3PDlizszN MXXTRW5ITVJ?
NCI-H650 NInkTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK2VYZKSzVyPUCuNVc3QDJizszN MkjEV2FPT0WU
KOSC-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETHPFFKSzVyPUCuNVc4OzRizszN M3vXVnNCVkeHUh?=
SCC-4 M3frWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMUe3O|ch|ryP M1TiUXNCVkeHUh?=
MDA-MB-157 NULNUo9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMUiwPFIh|ryP NXPiRWIzW0GQR1XS
KYSE-520 NFrn[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTKOHVwUUN3ME2wMlE5OiEQvF2= NVq1TFJHW0GQR1XS
LK-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWCzVVFDUUN3ME2wMlE5OzB|IN88US=> NWCyenBkW0GQR1XS
KNS-81-FD NG\BSYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMUizPVQh|ryP MVXTRW5ITVJ?
IGROV-1 NIrVeHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHzTWM2OD1yLkG4OFQ{KM7:TR?= NYfL[5RXW0GQR1XS
DEL MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDZbYlnUUN3ME2wMlE5PDVizszN Mnu0V2FPT0WU
NCI-H1395 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFziNFlKSzVyPUCuNVg3QDJizszN MYnTRW5ITVJ?
JEG-3 NXvVeHh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33yTGlEPTB;MD6xPFcxPSEQvF2= M{XwXHNCVkeHUh?=
BCPAP MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XNTGlEPTB;MD6xPFg4OiEQvF2= MVLTRW5ITVJ?
CAL-27 NGLHUI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMUmwNlIh|ryP MlqwV2FPT0WU
RD Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMUmxNVMh|ryP M4O4NnNCVkeHUh?=
RVH-421 NVzJ[FdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzKRXpPUUN3ME2wMlE6OTF4IN88US=> MkHXV2FPT0WU
Capan-2 NX:yU28zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMUmyOVYh|ryP NGTKPHNUSU6JRWK=
COLO-680N NILhUIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHpZXpKSzVyPUCuNVk{PjRizszN MUjTRW5ITVJ?
NCI-H1650 MoHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj0cYdKSzVyPUCuNlAxPTdizszN MoC3V2FPT0WU
SBC-5 MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnWyTWM2OD1yLkKwNVE5KM7:TR?= NFHzV2RUSU6JRWK=
U031 NHjC[I5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DYdGlEPTB;MD6yNFU1PyEQvF2= M2LsXHNCVkeHUh?=
S-117 NFWyUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMkC1OlQh|ryP NVrKfoYxW0GQR1XS
DoTc2-4510 M2fZ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnLTWM2OD1yLkKwO|Y6KM7:TR?= M3G3VHNCVkeHUh?=
AM-38 MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW3TWM2OD1yLkKwPFQ5KM7:TR?= MU\TRW5ITVJ?
A172 M1zqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPjUW9KSzVyPUCuNlExOjJizszN NGD0S3BUSU6JRWK=
HPAF-II NVTNWZN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\XT2lEPTB;MD6yNVI3PCEQvF2= NYfC[XR[W0GQR1XS
769-P MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zSc2lEPTB;MD6yNVI5KM7:TR?= NXzyS2g3W0GQR1XS
MFE-280 NYLrNJhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7MS45iUUN3ME2wMlIyOjl6IN88US=> MX\TRW5ITVJ?
TE-9 NXPBXmkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMkG3PFYh|ryP NHPuOnRUSU6JRWK=
C2BBe1 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuyO4pKSzVyPUCuNlIyQSEQvF2= MXPTRW5ITVJ?
EoL-1-cell M3Paemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMkKyNFMh|ryP NXPSO2RkW0GQR1XS
G-361 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DFXGlEPTB;MD6yNlY5OiEQvF2= MmDJV2FPT0WU
KYSE-270 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrs[Jl[UUN3ME2wMlI{ODh2IN88US=> M4G4[XNCVkeHUh?=
TK10 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnvVI5KSzVyPUCuNlMyOTdizszN NF7KSohUSU6JRWK=
ML-2 Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonWTWM2OD1yLkKzNVE6KM7:TR?= NGS3OnVUSU6JRWK=
MHH-ES-1 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMkO2PFEh|ryP Mki2V2FPT0WU
BHY Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMkO2PVEh|ryP MXXTRW5ITVJ?
LS-513 NWG4foRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD5dIFKSzVyPUCuNlM6PjFizszN MV7TRW5ITVJ?
COLO-678 NF:ySWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMkSwOFQh|ryP NFX6XnZUSU6JRWK=
NCI-H747 MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX1TWM2OD1yLkK0NVY6KM7:TR?= MkXLV2FPT0WU
K5 NVvPOHpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMkSzPEDPxE1? NFL2SmlUSU6JRWK=
OS-RC-2 M4TpWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny1TWM2OD1yLkK0OVA6KM7:TR?= MkS4V2FPT0WU
KINGS-1 NGiyd|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPsSHRPUUN3ME2wMlI1PTJ7IN88US=> MUXTRW5ITVJ?
SCC-25 NHHSfHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX5OG4{UUN3ME2wMlI1PTZ|IN88US=> MWrTRW5ITVJ?
CAPAN-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPtRW5KSzVyPUCuNlQ4QDNizszN NYS0XoFEW0GQR1XS
ESS-1 Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLsTWM2OD1yLkK0PFA2KM7:TR?= NXrRWFFqW0GQR1XS
TE-6 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMkW3OUDPxE1? NYjQ[XVkW0GQR1XS
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A253 NV;nblM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXJc5ljUUN3ME2xMlgzOjN7IN88US=> MnryV2FPT0WU
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NCI-H226 NY\oV2k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjydIRjUUN3ME2xMlg6OzV7IN88US=> NFfGbXRUSU6JRWK=
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NCI-H441 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj5VWtzUUN3ME2yMlAzOzN5IN88US=> NWrROmtnW0GQR1XS
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SJRH30 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3aU|dxUUN3ME2yMlA1OjV|IN88US=> NIPuN5lUSU6JRWK=
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NH-12 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJwMUWwNFYh|ryP MYLTRW5ITVJ?
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EW-22 NGXNc2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDZTWM2OD1{LkmyPFQyKM7:TR?= NF73WldUSU6JRWK=
DB M1rZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDyT45vUUN3ME2yMlk4PzV7IN88US=> M3nT[3NCVkeHUh?=
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NCI-H2029 Mmn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTNwMkK0O|ch|ryP NEfiUnhUSU6JRWK=
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CW-2 Ml;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu2U4t2UUN3ME2zMlU2OzF2IN88US=> MnHUV2FPT0WU
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NCI-H1993 NIrSXlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnFdm96UUN3ME23Mlg{ODZ|IN88US=> NX7PR3U3W0GQR1XS
RH-1 NIPNWZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHnRVFSUUN3ME23Mlg2OjR2IN88US=> MmK3V2FPT0WU
SW948 M1LSUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:xUVlKSzVyPUeuPVYxPDlizszN MV\TRW5ITVJ?
CAL-33 MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\jTWM2OD15Lkm5PVM5KM7:TR?= MlT4V2FPT0WU
U-266 NGnGZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPP[IxKSzVyPUiuNVU4PzdizszN MYHTRW5ITVJ?
CAL-72 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TnPWlEPTB;OD6yNFMzKM7:TR?= MUPTRW5ITVJ?
SNU-423 NWDv[GRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\aTWM2OD17LkO2OlY3KM7:TR?= NVzDbW5HW0GQR1XS
KG-1 NIS1RmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jwfGlEPTB;OT61PFQ2PiEQvF2= M3y4OXNCVkeHUh?=
HCC1395 MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG4dG5KSzVyPUmuPVI{PTJizszN M4Ds[XNCVkeHUh?=
BE-13 NWq4TpE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTFyLki4PVIh|ryP Mlr0V2FPT0WU
MKN7 NIf5SohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;3OXNKSzVyPUGwMlk4PjVizszN MoC1V2FPT0WU
697 M4DCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDWVZhRUUN3ME2xNU4yPDd{IN88US=> Mli2V2FPT0WU
LU-135 NX7BfXlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Dze2lEPTB;MUGuNlMxPyEQvF2= NXOweoFQW0GQR1XS
ES7 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz2dVlQUUN3ME2xNU4{OzF|IN88US=> NGDxXFRUSU6JRWK=
SK-HEP-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILyNGJKSzVyPUGxMlc3PDZizszN MXrTRW5ITVJ?
BEN NVT1TGNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFK1Z4VKSzVyPUGxMlg2OSEQvF2= MVTTRW5ITVJ?
NCI-H1770 NWPkNFB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjVdXlKSzVyPUGyMlEzPiEQvF2= MYTTRW5ITVJ?
SW13 NU\FR5NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17SemlEPTB;MUKuNVU1OSEQvF2= NUDpS3RwW0GQR1XS
MZ1-PC MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLjR3lKSzVyPUGyMlU1PTJizszN M{HVZnNCVkeHUh?=
Mo-T M4fFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfmOYZqUUN3ME2xNk44PDJzIN88US=> NXixU2JUW0GQR1XS
HLE NHP5NFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO0TWM2OD1zMj64NlE2KM7:TR?= MkXkV2FPT0WU
RCC10RGB M1:xTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki3TWM2OD1zMz62O|Eh|ryP M{fObXNCVkeHUh?=
COLO-320-HSR NUK2eo93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HoTWlEPTB;MUOuO|M5OSEQvF2= NUH5[JBWW0GQR1XS
BHT-101 NYjkW|U4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HWXWlEPTB;MUOuPFM1PSEQvF2= NGfifnJUSU6JRWK=
OCUB-M NFr4[4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP0Rm9TUUN3ME2xOE4yPjB{IN88US=> NYjkcmJ4W0GQR1XS
MEG-01 NXrlelFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW5dJhKSzVyPUG0MlM4ODhizszN MWDTRW5ITVJ?
RS4-11 NXTpfY1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrHcFBJUUN3ME2xOE44PDJizszN M4XxNXNCVkeHUh?=
MN-60 NXrnVnlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfoV5lKSzVyPUG0Mlc5QTRizszN Mn\3V2FPT0WU
NCI-H1304 MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfvfoNKSzVyPUG1MlA1OjVizszN NFLiVY1USU6JRWK=
Ramos-2G6-4C10 MnPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\lWmlEPTB;MUWuNFU5OSEQvF2= M{\aU3NCVkeHUh?=
NCI-H2342 NIjTVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX2WoJKSzVyPUG1MlIxPDRizszN MmPmV2FPT0WU
LAN-6 MnnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qweWlEPTB;MUWuOFQyPCEQvF2= M3LqXXNCVkeHUh?=
JVM-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq0PYFKSzVyPUG1MlU4PDhizszN NUPmR41KW0GQR1XS
P30-OHK MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HVfGlEPTB;MU[uNFYyPCEQvF2= M1K0WnNCVkeHUh?=
C-33-A MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLYToJKSzVyPUG2MlYzOTRizszN MliyV2FPT0WU
RPMI-8866 NV:wOVRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTF4Lki0PVYh|ryP MVPTRW5ITVJ?
NCI-H630 M4LjS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHiSlZKSzVyPUG2Mlg2OzdizszN MVLTRW5ITVJ?
KYSE-140 M3mwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[1NoN[UUN3ME2xO{4zODJ6IN88US=> Mo[zV2FPT0WU
T84 NVLteGp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX4[pdKSzVyPUG4Mlg3QTVizszN M{n2d3NCVkeHUh?=
KU-19-19 NHXiN3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLpTWM2OD1zOD65OlA5KM7:TR?= M1:yfXNCVkeHUh?=
BALL-1 NXezfow6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\Od2lEPTB;MUmuN|M6QSEQvF2= Ml\tV2FPT0WU
Calu-6 Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTQTWM2OD1zOT60PVIh|ryP MVPTRW5ITVJ?
EGI-1 MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPi[mZKSzVyPUG5MlU6QCEQvF2= M{X2RnNCVkeHUh?=
MFH-ino M2jzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfGTWM2OD1zOT63OFU1KM7:TR?= MVXTRW5ITVJ?
GB-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIX6NJBKSzVyPUKwMlM2OzVizszN MlfDV2FPT0WU
NCI-H1693 M1S1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXwTWM2OD1{MD62OVA2KM7:TR?= M{njfnNCVkeHUh?=
SW1116 MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTnTWM2OD1{MD65N|YzKM7:TR?= M2PscnNCVkeHUh?=
H-EMC-SS MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;yeVlKSzVyPUKyMlA1PSEQvF2= NEnjcZRUSU6JRWK=
D-502MG M2\rPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJ{LkiyOlEh|ryP NHv2dHFUSU6JRWK=
IA-LM NYjpZXk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJ|LkK0PVMh|ryP NFSyRohUSU6JRWK=
SW1463 NFj0ZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rLU2lEPTB;MkOuO|kh|ryP M1zXU3NCVkeHUh?=
JAR MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDHPVhKSzVyPUK0MlMzQTNizszN NXXIXphWW0GQR1XS
HT NXvJSY5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzEWIFUUUN3ME2yOE41PzV|IN88US=> MUjTRW5ITVJ?
LCLC-103H NX[2XZh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LveWlEPTB;MkSuPFQ1QSEQvF2= MlrnV2FPT0WU
SNU-449 NVr4XJdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJ2Lki3OFEh|ryP NHfzUXNUSU6JRWK=
KE-37 MmHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P0TWlEPTB;MkWuNFkzQCEQvF2= M{i4eHNCVkeHUh?=
NCI-H1623 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;ZTWM2OD1{Nz6xN|A{KM7:TR?= NEL5bHdUSU6JRWK=
MOLT-13 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzobZVKSzVyPUK3MlM2OTZizszN NFLpfopUSU6JRWK=
COLO-741 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LOe2lEPTB;M{GuN|M{OyEQvF2= NWXZ[mZEW0GQR1XS
NB6 NYfQVIR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{S3VGlEPTB;M{KuNlg4PiEQvF2= Mn3QV2FPT0WU
MOLT-16 NHvWZWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTN|LkCwOVUh|ryP M3TSN3NCVkeHUh?=
IST-MES1 Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDiWY5KSzVyPUO0MlA2PDFizszN MUDTRW5ITVJ?
A4-Fuk NXO2[VBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfwXXBXUUN3ME2zOU4xPjZizszN MnfuV2FPT0WU
CAL-85-1 M2P3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXrcZdUUUN3ME2zOU4zQDF5IN88US=> NUjjVoJbW0GQR1XS
CCRF-CEM NU\DcWZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS2TWM2OD1|Nz6xOVM3KM7:TR?= MVLTRW5ITVJ?
HAL-01 NHvD[|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NImxZ45KSzVyPUO4MlQ5QDlizszN M4rWXXNCVkeHUh?=
HEL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTR|LkO0NFkh|ryP MXrTRW5ITVJ?
EW-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfyWlQ6UUN3ME20N{41PzZ6IN88US=> M1fSZ3NCVkeHUh?=
MDA-MB-231 Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTR3LkGxPVkh|ryP M2T1bHNCVkeHUh?=
ABC-1 NUDWWYdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X6PWlEPTB;NE[uPFU{QCEQvF2= M1vvR3NCVkeHUh?=
NCI-H446 NWewfnprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTMV2RKSzVyPUS4MlUxPThizszN MlnQV2FPT0WU
MHH-PREB-1 NHvTSlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M162NmlEPTB;NEmuOlAxPyEQvF2= NGrNOYlUSU6JRWK=
DOHH-2 NFvFNoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HycmlEPTB;NEmuOlY2PiEQvF2= NVf2W2F2W0GQR1XS
GCT MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnHXmV5UUN3ME20PU43QTd4IN88US=> MUnTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]
臨床試験 A Phase II study of 17-AAG in patients with relapsed/refractory CD30 plus anaplastic large cell lymphoma (ALCL) relapsed/refractory mantle cell lymphoma (MCL) and relapsed/refractory classical Hodgkin's lymphoma (HL) has been completed.
特集 Displays very low toxicity toward normal cells.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Hsp90 binding assays Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.

細胞アッセイ: [1]

細胞株 BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 5 days
実験の流れ Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.

動物実験: [2]

動物モデル Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
製剤 Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
投薬量 ~50 mg/kg
投与方法 Injection i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download 17-AAG (Tanespimycin) SDF
分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管 3年-20℃
2年-80℃in solvent
別名 CP127374,NSC-330507, KOS 953
溶解度 (25°C) * In vitro DMSO 100 mg/mL (170.73 mM)
Ethanol 5 mg/mL (8.53 mM)
Water <1 mg/mL
In vivo 5%DMSO+corn oil 10mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 17-demethoxy-17-(2-propenylamino)- [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

文献中の引用 (19)

Frequently Asked Questions

  • Question 1
    What kind of subtypes does this compound inhibit? HSP90α or HSP90β ?

    Answer: 17-AAG can inhibit both HSP90α and HSP90β, but it is unclear how much are they affected respectively. You should note that Hsp90 derived from tumor cells has a 100-fold higher binding affinity for 17-AAG than that from normal cells according to this paper. http://www.nature.com.ezp-prod1.hul.harvard.edu/nature/journal/v425/n6956/full/nature01913.html

技術サポート&よくある質問(FAQ)

ストックの作り方、阻害剤の保管する方法、細胞実験や動物実験に注意すべきな点を全部含めており、製品を取扱う時よくあった質問に対して取扱説明書でお答えいたします。

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* 必須

Related HSP (e.g. HSP90) 阻害剤

  • PU-H71

    PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.

  • KNK437

    KNK437は1種のパン(pan)- HSP 阻害剤で、誘導HSPsの合成(HSP105、 HSP72,と HSP40を含める)を抑制します。

  • VER155008

    VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

  • FRAX597

    FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.

  • Luminespib (AUY-922, NVP-AUY922)

    Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090)は独特な triazolone-containing Hsp90阻害剤、 IC50 が4 nM となる.

  • 17-DMAG (Alvespimycin) HCl

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    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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