17-AAG (Tanespimycin) 化学構造
分子量: 585.69

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Quality Control & MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 17-AAG (Tanespimycin)は、5nMのIC50による強力な熱ショックタンパク質90(Hsp90)阻害剤です。
ターゲット HSP90
IC50 5 nM [1]
In vitro試験 17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A549 M1nmR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDjS5JKSzVyPUCuNFAxOzB|IN88US=> NIf3THFUSU6JRWK=
IST-MEL1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMECwOFA4KM7:TR?= NYfXW5ZtW0GQR1XS
NCI-SNU-1 NX;VT4F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{foOmlEPTB;MD6wNFIxPyEQvF2= MnTGV2FPT0WU
FADU NXzZOYpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzYbFJKSzVyPUCuNFAzODlizszN NGLyWIdUSU6JRWK=
C32 NWXOSotjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DZfWlEPTB;MD6wNFMxPCEQvF2= MmPHV2FPT0WU
D-566MG NUjjN3dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P1N2lEPTB;MD6wNFM6KM7:TR?= M12zSHNCVkeHUh?=
LXF-289 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDaWmZKSzVyPUCuNFA1OTlizszN M3z5Z3NCVkeHUh?=
HGC-27 NU\Rd3hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrWU4lKSzVyPUCuNFA2OSEQvF2= MnP3V2FPT0WU
RPMI-7951 NH7pW4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TZcGlEPTB;MD6wNFcyPyEQvF2= MX3TRW5ITVJ?
HSC-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP2bZhKSzVyPUCuNFA6OjlizszN MWjTRW5ITVJ?
MIA-PaCa-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XPbGlEPTB;MD6wNVAxQSEQvF2= MXzTRW5ITVJ?
KS-1 Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEGzOVUh|ryP NGTTcotUSU6JRWK=
CAL-51 NX\tZ5hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3ZRoZKSzVyPUCuNFE1ODVizszN MlHBV2FPT0WU
MDA-MB-361 NGrIbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[5bYg6UUN3ME2wMlAyPDl3IN88US=> M3\WV3NCVkeHUh?=
TI-73 NULJNnFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDCOlcxUUN3ME2wMlAyPzl4IN88US=> M2W2RnNCVkeHUh?=
AGS MlLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HkVGlEPTB;MD6wNVk{QCEQvF2= NEntem1USU6JRWK=
NCI-H460 NYLBOmxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX1TWM2OD1yLkCxPVc1KM7:TR?= NXvufHNZW0GQR1XS
A204 M2naSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjRS4VKSzVyPUCuNFIzPDlizszN MkX3V2FPT0WU
CHL-1 M4LMfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzJdndKSzVyPUCuNFIzPTFizszN NFXDZ|JUSU6JRWK=
DU-4475 Mki2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Hw[GlEPTB;MD6wNlI3OSEQvF2= MlPNV2FPT0WU
CGTH-W-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX5TWM2OD1yLkCyN|Q6KM7:TR?= MVjTRW5ITVJ?
HCC2218 NGLJToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DH[WlEPTB;MD6wNlQ6PCEQvF2= Ml3iV2FPT0WU
A2780 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7YXXBKSzVyPUCuNFI2OzFizszN NFTHZY5USU6JRWK=
NCI-H720 NH;IOGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7KUnN5UUN3ME2wMlAzPTR4IN88US=> NYT2TYJoW0GQR1XS
NCI-N87 M4KyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEK1PVMh|ryP NXrSR3N3W0GQR1XS
CHP-212 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXvUG14UUN3ME2wMlAzPjJ6IN88US=> NInvW2hUSU6JRWK=
NCI-H23 NXT2S3pjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXCTWM2OD1yLkCyOlY2KM7:TR?= MVnTRW5ITVJ?
D-263MG NEjUV4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq5TWM2OD1yLkCyO|g3KM7:TR?= M{iwV3NCVkeHUh?=
ME-180 NWnLPVRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIflSVVKSzVyPUCuNFI5QTFizszN MUjTRW5ITVJ?
SW982 M1TpSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEK5PVkh|ryP Ml:3V2FPT0WU
OE19 NXvmU491T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n3SGlEPTB;MD6wN|A4PyEQvF2= NILtR3NUSU6JRWK=
SK-LU-1 NGDHSWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLOTWM2OD1yLkCzNFgzKM7:TR?= Mn3yV2FPT0WU
H4 NWLFfYdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEOwPUDPxE1? MYDTRW5ITVJ?
HT-144 NILIVG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\GTWM2OD1yLkCzNFk{KM7:TR?= M1mzNHNCVkeHUh?=
SK-UT-1 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPLOnVPUUN3ME2wMlA{OTd6IN88US=> NXfKZZlYW0GQR1XS
D-336MG M3ixVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzZR3ZKSzVyPUCuNFM{ODlizszN Mlf6V2FPT0WU
MDA-MB-175-VII NUjLeZBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEOzOVQh|ryP M4Pw[3NCVkeHUh?=
GAMG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnZbWVQUUN3ME2wMlA{PDN3IN88US=> M4P0[nNCVkeHUh?=
CP50-MEL-B MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfpNnV5UUN3ME2wMlA{PDVizszN MXXTRW5ITVJ?
OVCAR-5 M1PoNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Hi[2lEPTB;MD6wN|Q5KM7:TR?= MlTKV2FPT0WU
SK-MES-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmW1TWM2OD1yLkCzOlA3KM7:TR?= M1TOVnNCVkeHUh?=
VM-CUB-1 NXjnfVZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIH6TmhKSzVyPUCuNFM3PTdizszN MWrTRW5ITVJ?
WM-115 M{C0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3Pb|NGUUN3ME2wMlA{PzZ{IN88US=> NXjEeHhNW0GQR1XS
DSH1 M1X2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMEO4NFch|ryP NYO1PXBxW0GQR1XS
Becker NID3RYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEO4PFUh|ryP MlLUV2FPT0WU
SW962 NF35SJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfvTWM2OD1yLkCzPVQ2KM7:TR?= NXi3Z|A4W0GQR1XS
TYK-nu M3XIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEO5PFUh|ryP NGrlcWxUSU6JRWK=
HO-1-N-1 NWnmV|BjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmq0TWM2OD1yLkC0NFIyKM7:TR?= Mnj1V2FPT0WU
T98G MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMESxNFMh|ryP M2rubXNCVkeHUh?=
ACN MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33VZmlEPTB;MD6wOFE3OiEQvF2= Mn3DV2FPT0WU
SW780 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm1O49KSzVyPUCuNFQzODNizszN NWLFV2ZIW0GQR1XS
Detroit562 NYHNXFZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET3V3hKSzVyPUCuNFQzOzlizszN NEj3WYJUSU6JRWK=
BB49-HNC NE\BPVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknvTWM2OD1yLkC0NlQ{KM7:TR?= NWL6S3V2W0GQR1XS
HN MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\yfFFKSzVyPUCuNFQzPzJizszN NYPsd2lMW0GQR1XS
H9 M4PXTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DTXGlEPTB;MD6wOFM4OSEQvF2= M4LSVnNCVkeHUh?=
VA-ES-BJ MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnRRpVKSzVyPUCuNFQ1PDdizszN M1jPeHNCVkeHUh?=
MEL-JUSO MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\zbo1kUUN3ME2wMlA1PDd3IN88US=> NITMW4tUSU6JRWK=
BT-474 NWnUN3NrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXvVoxmUUN3ME2wMlA1PSEQvF2= M2C3cHNCVkeHUh?=
CaR-1 NFXGTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLx[GhvUUN3ME2wMlA1PTR7IN88US=> NVPaTmVqW0GQR1XS
PSN1 M3nkdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjSTWM2OD1yLkC0OlA{KM7:TR?= NVXHTlVIW0GQR1XS
KYSE-510 NXnPTHJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv6NZdKSzVyPUCuNFQ3PDlizszN NFXZUXNUSU6JRWK=
KP-4 NFvRN5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfteoNSUUN3ME2wMlA1PzV|IN88US=> MnT3V2FPT0WU
KYSE-410 MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMES3O|Ih|ryP MnP4V2FPT0WU
G-402 MnrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkWwTWM2OD1yLkC0O|g6KM7:TR?= NUTrN5BRW0GQR1XS
DOK NWjJ[4ZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMES5NFIh|ryP NGjOcGNUSU6JRWK=
COR-L88 M{PvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK2UGZIUUN3ME2wMlA1QTF{IN88US=> NVHad|QzW0GQR1XS
SKG-IIIa MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnV[olKSzVyPUCuNFQ6QDZizszN NUPiTHExW0GQR1XS
AN3-CA M3fBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TE[mlEPTB;MD6wOUDPxE1? NVLSV|JHW0GQR1XS
SW48 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLGRpcxUUN3ME2wMlA2ODN7IN88US=> MlPvV2FPT0WU
YKG-1 MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPQeFVtUUN3ME2wMlA2ODdzIN88US=> MUjTRW5ITVJ?
KYSE-150 NWDPc|V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDzTWM2OD1yLkC1NlM2KM7:TR?= MY\TRW5ITVJ?
HuO-3N1 NGrTW|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDTXYVKSzVyPUCuNFUzOzdizszN NYS0d2x{W0GQR1XS
LB1047-RCC MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPQTWM2OD1yLkC1Nlk3KM7:TR?= NXfTelZUW0GQR1XS
NCI-H2030 NH;CWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\o[GlEPTB;MD6wOVQyPCEQvF2= NIDMbHlUSU6JRWK=
YH-13 NUXCXYxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEW3NlIh|ryP MYnTRW5ITVJ?
5637 M3XUcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rXWWlEPTB;MD6wOVc1KM7:TR?= NY\4[nE5W0GQR1XS
LOXIMVI M1uyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEW4O|Ih|ryP M1fXOXNCVkeHUh?=
GT3TKB MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:5d5A1UUN3ME2wMlA2QTR{IN88US=> Ml7DV2FPT0WU
TCCSUP NX\ne2w6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[zcVdLUUN3ME2wMlA2QTZ2IN88US=> MkK5V2FPT0WU
EPLC-272H NI\0XG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXtTI1rUUN3ME2wMlA3OjB3IN88US=> M1zWbXNCVkeHUh?=
LU-99A M{HXO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DDd2lEPTB;MD6wOlI{PyEQvF2= MmHNV2FPT0WU
NCI-H1755 M3S1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIryXY9KSzVyPUCuNFY{PDFizszN M1PLcXNCVkeHUh?=
KM12 M{jpWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnmxTWM2OD1yLkC2N|Q5KM7:TR?= NUTyN5loW0GQR1XS
SF295 M2LrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\NSGZKSzVyPUCuNFY1PTJizszN NWTOclV5W0GQR1XS
MZ2-MEL Mn7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;jXWFKSzVyPUCuNFY2PTNizszN NHTzdmJUSU6JRWK=
HEC-1 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO1TWM2OD1yLkC2OVg5KM7:TR?= MVXTRW5ITVJ?
SW684 MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkntTWM2OD1yLkC2OVkyKM7:TR?= NV;mdII6W0GQR1XS
SF539 M1fBUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDpfXgyUUN3ME2wMlA3PjhzIN88US=> NFHIb|lUSU6JRWK=
GMS-10 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrGTWM2OD1yLkC2Olk6KM7:TR?= M17NWXNCVkeHUh?=
MV-4-11 MnvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELBdG5KSzVyPUCuNFY5ODNizszN Mmm4V2FPT0WU
HT-29 NVXQSXhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PIeWlEPTB;MD6wOlkyQSEQvF2= NX\iclB{W0GQR1XS
23132-87 M1P5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwME[5OUDPxE1? NE[2Z4RUSU6JRWK=
SW620 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDVUGJ3UUN3ME2wMlA4ODJ4IN88US=> MVXTRW5ITVJ?
HCC1806 NUPpRYFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEexN|Eh|ryP MoDsV2FPT0WU
Hs-578-T NXnjcYc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;lVo1KSzVyPUCuNFczODhizszN M{XZWHNCVkeHUh?=
A2058 NHXqcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIf1U4NKSzVyPUCuNFczOjhizszN MVHTRW5ITVJ?
MEL-HO MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHiTWM2OD1yLkC3NlU2KM7:TR?= MUHTRW5ITVJ?
HCC2998 NVnpVXNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHGO2ExUUN3ME2wMlA4OzR5IN88US=> NXHSZ5RYW0GQR1XS
HuO9 NXzofYtWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrocm1JUUN3ME2wMlA4PTh7IN88US=> NXznVI9sW0GQR1XS
CAL-39 NUXkeo14T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\Oe2lEPTB;MD6wO|c3PiEQvF2= NYW2[3F6W0GQR1XS
M14 NVnWNpp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP5VFdzUUN3ME2wMlA4QTF|IN88US=> M3fEbnNCVkeHUh?=
BFTC-909 MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfudHNKSzVyPUCuNFc6PjlizszN MUPTRW5ITVJ?
TE-11 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEe5PVYh|ryP M4G4e3NCVkeHUh?=
TGBC1TKB M{XHfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLkdldKSzVyPUCuNFgxPDNizszN NVLZc41qW0GQR1XS
L-363 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTVTWM2OD1yLkC4NlA3KM7:TR?= NV3adYViW0GQR1XS
A431 NFXSU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXFfXNKSzVyPUCuNFgzOSEQvF2= Mn;IV2FPT0WU
MKN45 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnBTWM2OD1yLkC4NlE6KM7:TR?= M{fwZXNCVkeHUh?=
HT-1080 NXv4WpB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEi0N|kh|ryP MlHGV2FPT0WU
OVCAR-8 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTiZW5KSzVyPUCuNFg3OjJizszN M2DmeHNCVkeHUh?=
LCLC-97TM1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPjfpNKSzVyPUCuNFg4OjhizszN NYPYOlU3W0GQR1XS
M059J NUPtOG1vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XSR2lEPTB;MD6wPVAzPyEQvF2= NG\wV5NUSU6JRWK=
SK-MEL-2 NULv[JFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fpXGlEPTB;MD6wPVA3KM7:TR?= MVnTRW5ITVJ?
TE-1 M3Xx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3BNHhNUUN3ME2wMlA6OjB2IN88US=> M{C4[HNCVkeHUh?=
KYSE-180 MnXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPu[5ZEUUN3ME2wMlA6OjZ{IN88US=> NIr6PZhUSU6JRWK=
D-247MG MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TQU2lEPTB;MD6wPVQ2PSEQvF2= MlfnV2FPT0WU
8-MG-BA MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonSTWM2OD1yLkC5OFczKM7:TR?= M1PobXNCVkeHUh?=
NCI-H1792 NWSxeJZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf5N2NKSzVyPUCuNFk3OThizszN MYnTRW5ITVJ?
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SN12C Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMUCxNFch|ryP MYfTRW5ITVJ?
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UACC-893 NVfYOJc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPjRoNHUUN3ME2wMlY{PjhzIN88US=> NWLwNnRTW0GQR1XS
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RPMI-8226 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHjO4NkUUN3ME2wMlY3OzJ|IN88US=> NHfQb2xUSU6JRWK=
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NCI-H358 NXTBWpZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjx[FRwUUN3ME2wMlY5PzJ4IN88US=> NVmxd|VNW0GQR1XS
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UACC-257 M2LtcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnMSmxRUUN3ME2wMlgzOjNzIN88US=> Mo\VV2FPT0WU
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P12-ICHIKAWA MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTdwNEW1NlMh|ryP MlHlV2FPT0WU
NCI-H82 NFiy[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXn2[WpxUUN3ME23MlQ2PzBzIN88US=> M3LIXXNCVkeHUh?=
NCI-H1993 MnzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTxdW9KSzVyPUeuPFMxPjNizszN MofCV2FPT0WU
RH-1 M1zrV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{mySmlEPTB;Nz64OVI1PCEQvF2= NX\QNFNCW0GQR1XS
SW948 M3vIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H0NmlEPTB;Nz65OlA1QSEQvF2= MY\TRW5ITVJ?
CAL-33 MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTdwOUm5N|gh|ryP MmDhV2FPT0WU
U-266 M3PXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRThwMUW3O|ch|ryP MUDTRW5ITVJ?
CAL-72 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRThwMkCzNkDPxE1? NY[w[ml5W0GQR1XS
SNU-423 M{f1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzVXmNKSzVyPUmuN|Y3PjZizszN NVjSb2lzW0GQR1XS
KG-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LOdGlEPTB;OT61PFQ2PiEQvF2= NILDU4hUSU6JRWK=
HCC1395 M2L6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTlwOUKzOVIh|ryP NFXabIRUSU6JRWK=
BE-13 NFfPeFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfw[|ZjUUN3ME2xNE45QDl{IN88US=> NV\s[XMzW0GQR1XS
MKN7 MmCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTFyLkm3OlUh|ryP NUXOS2xsW0GQR1XS
697 NIjWdGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\xTWM2OD1zMT6xOFczKM7:TR?= Mmr0V2FPT0WU
LU-135 NVHyVXo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkG5TWM2OD1zMT6yN|A4KM7:TR?= NHnCVXVUSU6JRWK=
ES7 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHztdmZKSzVyPUGxMlM{OTNizszN NHOwZohUSU6JRWK=
SK-HEP-1 NH3LOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvkTWM2OD1zMT63OlQ3KM7:TR?= MYrTRW5ITVJ?
BEN MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTFzLki1NUDPxE1? Mlj3V2FPT0WU
NCI-H1770 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rleWlEPTB;MUKuNVI3KM7:TR?= MnzNV2FPT0WU
SW13 NXLn[G95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfGTWM2OD1zMj6xOVQyKM7:TR?= NXq1XZFMW0GQR1XS
MZ1-PC MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTlR|ZKSzVyPUGyMlU1PTJizszN MY\TRW5ITVJ?
Mo-T NGHWZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fibmlEPTB;MUKuO|QzOSEQvF2= NYPYcGU4W0GQR1XS
HLE NEftUVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrycFlwUUN3ME2xNk45OjF3IN88US=> NXT2bFlTW0GQR1XS
RCC10RGB MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jlXmlEPTB;MUOuOlcyKM7:TR?= MWHTRW5ITVJ?
COLO-320-HSR NGrvW|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDPXFBWUUN3ME2xN{44OzhzIN88US=> M2XRVXNCVkeHUh?=
BHT-101 NYnS[m5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzROYhWUUN3ME2xN{45OzR3IN88US=> MXvTRW5ITVJ?
OCUB-M Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjPTWM2OD1zND6xOlAzKM7:TR?= M1:ydnNCVkeHUh?=
MEG-01 NVeyUow3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW0SolKSzVyPUG0MlM4ODhizszN NVP0N2RPW0GQR1XS
RS4-11 NFywSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jiVWlEPTB;MUSuO|QzKM7:TR?= M2LjT3NCVkeHUh?=
MN-60 M3zxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi1WXBKSzVyPUG0Mlc5QTRizszN MY\TRW5ITVJ?
NCI-H1304 NWX2XXM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPxTWM2OD1zNT6wOFI2KM7:TR?= MULTRW5ITVJ?
Ramos-2G6-4C10 NFrrXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnvb4w6UUN3ME2xOU4xPThzIN88US=> NE\rb3VUSU6JRWK=
NCI-H2342 NYLXcHhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTlS5ZNUUN3ME2xOU4zODR2IN88US=> M2XvXnNCVkeHUh?=
LAN-6 NFTmUI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWWwZnN[UUN3ME2xOU41PDF2IN88US=> NEjiVJBUSU6JRWK=
JVM-2 M37lWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\XZXA6UUN3ME2xOU42PzR6IN88US=> Mnn5V2FPT0WU
P30-OHK NELNboNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLaNod[UUN3ME2xOk4xPjF2IN88US=> MlOwV2FPT0WU
C-33-A NHX2XlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTRWXRDUUN3ME2xOk43OjF2IN88US=> NGPQbFJUSU6JRWK=
RPMI-8866 M1jSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXSxZ3o{UUN3ME2xOk45PDl4IN88US=> NWS2TVNoW0GQR1XS
NCI-H630 M3z0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\N[VVKSzVyPUG2Mlg2OzdizszN NViw[3U3W0GQR1XS
KYSE-140 NFPjOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7JS5VKSzVyPUG3MlIxOjhizszN NWn3fWY4W0GQR1XS
T84 NXjSdXpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjyTWM2OD1zOD64Olk2KM7:TR?= MYfTRW5ITVJ?
KU-19-19 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLZTWM2OD1zOD65OlA5KM7:TR?= MXHTRW5ITVJ?
BALL-1 MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M162dGlEPTB;MUmuN|M6QSEQvF2= NGDROGFUSU6JRWK=
Calu-6 M3\vPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGmwU|NKSzVyPUG5MlQ6OiEQvF2= NVzoRYlkW0GQR1XS
EGI-1 M{jCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DlUGlEPTB;MUmuOVk5KM7:TR?= M4jiV3NCVkeHUh?=
MFH-ino MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLxTWM2OD1zOT63OFU1KM7:TR?= M3PJSHNCVkeHUh?=
GB-1 Mn;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJyLkO1N|Uh|ryP NWD4UFFzW0GQR1XS
NCI-H1693 NX7iSYROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTuUGd5UUN3ME2yNE43PTB3IN88US=> NIKxcGFUSU6JRWK=
SW1116 Mn3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\rTWM2OD1{MD65N|YzKM7:TR?= M3XhVnNCVkeHUh?=
H-EMC-SS NUHYbVZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDHZnhKSzVyPUKyMlA1PSEQvF2= MYnTRW5ITVJ?
D-502MG NFnHR2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJ{LkiyOlEh|ryP Mo\FV2FPT0WU
IA-LM MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PkUWlEPTB;MkOuNlQ6OyEQvF2= NYTK[WlyW0GQR1XS
SW1463 NFLSSFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJ|Lke5JO69VQ>? MWLTRW5ITVJ?
JAR NYLmXXdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ2LkOyPVMh|ryP M{fM[3NCVkeHUh?=
HT NFmzOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnoeJZTUUN3ME2yOE41PzV|IN88US=> MnnoV2FPT0WU
LCLC-103H MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJ2Lki0OFkh|ryP NIHHOG1USU6JRWK=
SNU-449 NXfPbVlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\VfmlEPTB;MkSuPFc1OSEQvF2= MXvTRW5ITVJ?
KE-37 NH\ZfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zoeGlEPTB;MkWuNFkzQCEQvF2= MkPjV2FPT0WU
NCI-H1623 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XXOGlEPTB;MkeuNVMxOyEQvF2= MWjTRW5ITVJ?
MOLT-13 NHzrOppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXRTWM2OD1{Nz6zOVE3KM7:TR?= NFezcGJUSU6JRWK=
COLO-741 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorJTWM2OD1|MT6zN|M{KM7:TR?= MVPTRW5ITVJ?
NB6 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXZ[m9LUUN3ME2zNk4zQDd4IN88US=> MYfTRW5ITVJ?
MOLT-16 NGXGSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILmXGVKSzVyPUOzMlAxPTVizszN MnfPV2FPT0WU
IST-MES1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTN2LkC1OFEh|ryP MlrYV2FPT0WU
A4-Fuk NUXWblRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rwe2lEPTB;M{WuNFY3KM7:TR?= NGj2S2pUSU6JRWK=
CAL-85-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTN3LkK4NVch|ryP MlHOV2FPT0WU
CCRF-CEM NX;POnkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPBTWM2OD1|Nz6xOVM3KM7:TR?= MlPIV2FPT0WU
HAL-01 NEDvRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPkWndKSzVyPUO4MlQ5QDlizszN NXvuVohpW0GQR1XS
HEL NED3WI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ftVmlEPTB;NEOuN|QxQSEQvF2= MmrTV2FPT0WU
EW-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYflW5o6UUN3ME20N{41PzZ6IN88US=> MnPHV2FPT0WU
MDA-MB-231 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq2TWM2OD12NT6xNVk6KM7:TR?= NFfsfVlUSU6JRWK=
ABC-1 M1zkVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7iTWM2OD12Nj64OVM5KM7:TR?= NHLuTG9USU6JRWK=
NCI-H446 MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXr[VNOUUN3ME20PE42ODV6IN88US=> NW\6epdqW0GQR1XS
MHH-PREB-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTR7Lk[wNFch|ryP MVnTRW5ITVJ?
DOHH-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHoTWM2OD12OT62OlU3KM7:TR?= MlL1V2FPT0WU
GCT NHTDVZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPhNotKSzVyPUS5MlY6PzZizszN M2foOXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]
臨床試験 A Phase II study of 17-AAG in patients with relapsed/refractory CD30 plus anaplastic large cell lymphoma (ALCL) relapsed/refractory mantle cell lymphoma (MCL) and relapsed/refractory classical Hodgkin's lymphoma (HL) has been completed.
特集 Displays very low toxicity toward normal cells.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Hsp90 binding assays Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.

細胞アッセイ: [1]

細胞株 BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 5 days
実験の流れ Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.

動物実験: [2]

動物モデル Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
製剤 Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
投薬量 ~50 mg/kg
投与方法 Injection i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download 17-AAG (Tanespimycin) SDF
分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管 2年-20℃
6月-80℃in solvent
別名 CP127374,NSC-330507, KOS 953
溶解度 (25°C) * In vitro DMSO 100 mg/mL (170.73 mM)
エタノール 5 mg/mL (8.53 mM)
<1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 17-demethoxy-17-(2-propenylamino)- [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

カスタマーフィードバック (7)


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Source , , PNAS, 2011, 108: 7535-40. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines H3122 & H3122 CR cells
Concentrations 10 nM
Incubation Time 72 h
Results As shown in Fig. A, 17-AAG potently suppressed cell growth in both parental H3122 and H3122 CR cells. However, in contrast to NVP-TAE684 and AP26113, 17-AAG also inhibited the viability of SKBR3 and BT474 cell lines. 17-AAG treatment decreased both p-ALK 眏Ỵ眐㠞眎膉癠 皐﷘ř᐀ŔřĀ 㺣癞帉癞Ѐ瑖兽ﱔᆊࣿřĀࣾ彿兾奋兾巫兾婶ࣿ橢ࣿ彿兾

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Rating
Source Oncotarget, 2014, 5, 4269-82. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines Ls-174T, HCT116, Caco2, Hke3 cells
Concentrations 0.5, 2 uM
Incubation Time 24 h
Results Colon cancer cells harboring WT or MT K-Ras were treated with 17-AAG and effects on the Ras expression were analyzed by WB. Results in Figure showed that incubation with 17-AAG only down-regulates K-Ras in K-Ras MT cells but decreases Raf-1 {an established Hsp90 client} in all cell lines. The result, for the first time, demonstrated that both transfected and endogenous MT K-Ras is an Hsp90 client protein.

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Rating
Source Oncotarget, 2015, 51: S659-S660. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines MOLT-4 & RS4;11 cells
Concentrations
Incubation Time 22 h
Results In both MOLT-4 and RS4;11 cells, the combined treatment inhibited the interactions between Hsp90 and BIP/Grp78 more effectively than CX-4945 single treatment and to the same extent as tanespimycin (17-AAG).

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Rating
Source Mol Cell Biol, 2013, 33(12), 2375-87. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines NIH 3T3 cells
Concentrations 25, 50 uM
Incubation Time 4 h
Results 17-AAG and SNX-2112, both of which induce the UPR by targeting the chaperone HSP90, decreased mSmoM2 protein levels (lanes 2 to 5 compared to lane 1), further supporting the sensitivity of active Smo mutants to UPR induction.

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Rating
Source J Biol Chem, 2012, 287, 44109-20. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines Dopaminergic Neuronal Cell lines
Concentrations 10-20uM
Incubation Time
Results As expected, both complex IV activity and Hsp60 levels exhibited a dose-dependent decrease in response to treatment with 17-AAG (Fig. 4A). However, 17-AAG treatment did not alter levels of Hsp90 and LRPPRC levels

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Rating
Source Mol Cancer, 2014, 13, 150. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines SKBR3 cells
Concentrations 1, 2 uM
Incubation Time 24 h
Results Hsp90 and Cdc37 protein levels showed no distinct change according to a drug concentration gradient, whereas Hsp70, a marker of Hsp90 inhibition, the protein level was greatly induced by treatment with 17AAG or FW-04-806.

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Rating
Source Age, 2013, 35, 549-62. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines HFSN1 cells
Concentrations 0.1/0.5uM
Incubation Time 24 h
Results Figure 2c shows that the decrease in the level of Hsp90 after treatment with 0.5 μM of 17-AAG was accompanied by a decrease in the level of both the survivin and phospho-survivin proteins.

文献中の引用 (18)

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  • 17-DMAG (Alvespimycin) HCl

    17-DMAG (Alvespimycin) HClは、62nMのIC50による強力なHsp90阻害剤です。

    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    ノーカット二量体Hsp90またはN末端領域Hsp90と結合している間、Geldanamycinは1.2のμMまたは0.78のμMによるKdによる天然既存のHsp90阻害剤です。

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

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Tags: 17-AAG (Tanespimycin)を買う | 17-AAG (Tanespimycin)供給者 | 17-AAG (Tanespimycin)を購入する | 17-AAG (Tanespimycin)費用 | 17-AAG (Tanespimycin)生産者 | オーダー17-AAG (Tanespimycin) | 17-AAG (Tanespimycin)代理店
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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