17-AAG (Tanespimycin) 化学構造
分子量: 585.69

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Quality Control & MSDS

製品説明

  • Compare HSP (e.g. HSP90) Inhibitors
    HSP (e.g. HSP90)製品生物活性の比較
  • 研究分野

製品の説明

生物活性

製品説明 17-AAG (Tanespimycin)は、5nMのIC50による強力な熱ショックタンパク質90(Hsp90)阻害剤です。
ターゲット HSP90
IC50 5 nM [1]
In vitro試験 17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. [1] 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. [2] In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
A549 M1HyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPTPWZtUUN3ME2wMlAxODNyMzFOwG0> M4LHenNCVkeHUh?=
IST-MEL1 MmnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDxTWM2OD1yLkCwNFQxPyEQvF2= NULIN3NqW0GQR1XS
NCI-SNU-1 NXOxW|M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\SXpFKSzVyPUCuNFAzODdizszN MVfTRW5ITVJ?
FADU MoXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDBTWM2OD1yLkCwNlA6KM7:TR?= MkOwV2FPT0WU
C32 NWDXT2RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMECzNFQh|ryP MkDiV2FPT0WU
D-566MG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnITY0xUUN3ME2wMlAxOzlizszN M173VXNCVkeHUh?=
LXF-289 M1raOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTqTWM2OD1yLkCwOFE6KM7:TR?= NULxXmxQW0GQR1XS
HGC-27 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHOTWM2OD1yLkCwOVEh|ryP NGKzbIxUSU6JRWK=
RPMI-7951 NUP5TW52T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEC3NVch|ryP MX\TRW5ITVJ?
HSC-3 NHvyR4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\oTWM2OD1yLkCwPVI6KM7:TR?= MYTTRW5ITVJ?
MIA-PaCa-2 NUDqPIxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\COmQ6UUN3ME2wMlAyODB7IN88US=> M2DsUHNCVkeHUh?=
KS-1 Mke0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEGzOVUh|ryP MkW1V2FPT0WU
CAL-51 M3fPeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPVdJFKSzVyPUCuNFE1ODVizszN MX7TRW5ITVJ?
MDA-MB-361 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEG0PVUh|ryP Mm\SV2FPT0WU
TI-73 MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEG3PVYh|ryP NHvK[IxUSU6JRWK=
AGS NUfMXVFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\pTWM2OD1yLkCxPVM5KM7:TR?= NXK3PY1JW0GQR1XS
NCI-H460 M17mXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3ZTldZUUN3ME2wMlAyQTd2IN88US=> MoT0V2FPT0WU
A204 M1P6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\QXJA6UUN3ME2wMlAzOjR7IN88US=> NF\GR|NUSU6JRWK=
CHL-1 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMEKyOVEh|ryP NUTNW2Y{W0GQR1XS
DU-4475 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW3S21KSzVyPUCuNFIzPjFizszN MoK3V2FPT0WU
CGTH-W-1 NV\4dGFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrPR4x6UUN3ME2wMlAzOzR7IN88US=> MXrTRW5ITVJ?
HCC2218 NFHCUIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEK0PVQh|ryP NX7hPVd3W0GQR1XS
A2780 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnETWM2OD1yLkCyOVMyKM7:TR?= M2\Yd3NCVkeHUh?=
NCI-H720 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXuPVhKSzVyPUCuNFI2PDZizszN MYLTRW5ITVJ?
NCI-N87 M3LWfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEK1PVMh|ryP MnW3V2FPT0WU
CHP-212 NHPjc5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\Fc2lEPTB;MD6wNlYzQCEQvF2= NVzGVFFbW0GQR1XS
NCI-H23 NXG1NVZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHqTWM2OD1yLkCyOlY2KM7:TR?= M{nrT3NCVkeHUh?=
D-263MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUO2dZlVUUN3ME2wMlAzPzh4IN88US=> M17C[3NCVkeHUh?=
ME-180 M2Dlb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEK4PVEh|ryP Mn\HV2FPT0WU
SW982 NWi4[2IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfLNoNKSzVyPUCuNFI6QTlizszN M2HnWHNCVkeHUh?=
OE19 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDpS4NTUUN3ME2wMlA{ODd5IN88US=> NV[0TFRtW0GQR1XS
SK-LU-1 Mk[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEOwPFIh|ryP Mm\hV2FPT0WU
H4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrKd2FKSzVyPUCuNFMxQSEQvF2= M{TX[HNCVkeHUh?=
HT-144 MofTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuyNHhKSzVyPUCuNFMxQTNizszN M4LxOXNCVkeHUh?=
SK-UT-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\teGpmUUN3ME2wMlA{OTd6IN88US=> MVnTRW5ITVJ?
D-336MG MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfpTWM2OD1yLkCzN|A6KM7:TR?= M3zi[nNCVkeHUh?=
MDA-MB-175-VII MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\4e4pKSzVyPUCuNFM{PTRizszN M4XsdnNCVkeHUh?=
GAMG M{TxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm2TWM2OD1yLkCzOFM2KM7:TR?= NIfIWnpUSU6JRWK=
CP50-MEL-B NX\5UpR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnIR3hKSzVyPUCuNFM1PSEQvF2= MXrTRW5ITVJ?
OVCAR-5 M4nGU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzn[ZhKSzVyPUCuNFM1QCEQvF2= M4DrUHNCVkeHUh?=
SK-MES-1 MoO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEO2NFYh|ryP NFnsTYJUSU6JRWK=
VM-CUB-1 MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEO2OVch|ryP MUfTRW5ITVJ?
WM-115 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHaXIlKSzVyPUCuNFM4PjJizszN NFzmVm5USU6JRWK=
DSH1 NF3aW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLlVIhKSzVyPUCuNFM5ODdizszN M33kdHNCVkeHUh?=
Becker NVjqSXdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHy[nRKSzVyPUCuNFM5QDVizszN MWrTRW5ITVJ?
SW962 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXDTWM2OD1yLkCzPVQ2KM7:TR?= Ml\5V2FPT0WU
TYK-nu NUCzWoNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TGfmlEPTB;MD6wN|k5PSEQvF2= Mn;QV2FPT0WU
HO-1-N-1 Ml7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHoTWM2OD1yLkC0NFIyKM7:TR?= NVu1RlhRW0GQR1XS
T98G MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnlTWM2OD1yLkC0NVA{KM7:TR?= M32wdXNCVkeHUh?=
ACN NXn1VnpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfTW2JKSzVyPUCuNFQyPjJizszN NXzkd4pVW0GQR1XS
SW780 NVHwWYZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\JUoQyUUN3ME2wMlA1OjB|IN88US=> M4LnVnNCVkeHUh?=
Detroit562 M4P3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7KSVN7UUN3ME2wMlA1OjN7IN88US=> NHf4XGtUSU6JRWK=
BB49-HNC NHeyepNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj0XlhOUUN3ME2wMlA1OjR|IN88US=> MV3TRW5ITVJ?
HN MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;VR2M1UUN3ME2wMlA1Ojd{IN88US=> NY[yfGt5W0GQR1XS
H9 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnUdYtwUUN3ME2wMlA1OzdzIN88US=> MYPTRW5ITVJ?
VA-ES-BJ M2\kPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PtNGlEPTB;MD6wOFQ1PyEQvF2= MVjTRW5ITVJ?
MEL-JUSO M4rxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;RVXVQUUN3ME2wMlA1PDd3IN88US=> MkfxV2FPT0WU
BT-474 M1TUS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMES1JO69VQ>? NH3kTHhUSU6JRWK=
CaR-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\rc2lEPTB;MD6wOFU1QSEQvF2= MnHYV2FPT0WU
PSN1 NWXqWIJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HC[mlEPTB;MD6wOFYxOyEQvF2= NH7KRoFUSU6JRWK=
KYSE-510 MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrzXVd6UUN3ME2wMlA1PjR7IN88US=> Mk\HV2FPT0WU
KP-4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXrO3RKSzVyPUCuNFQ4PTNizszN NXrhbmdbW0GQR1XS
KYSE-410 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW4XppKSzVyPUCuNFQ4PzJizszN Ml;EV2FPT0WU
G-402 M{frOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHSeINKSzVyPUCuNFQ4QDlizszN NYTUb|F7W0GQR1XS
DOK MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf3VYoxUUN3ME2wMlA1QTB{IN88US=> MX;TRW5ITVJ?
COR-L88 NV3hcZMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDqUo9KSzVyPUCuNFQ6OTJizszN MkfhV2FPT0WU
SKG-IIIa NVS5coU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvKXGk5UUN3ME2wMlA1QTh4IN88US=> Mn3TV2FPT0WU
AN3-CA NHzacFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7LTmY1UUN3ME2wMlA2KM7:TR?= M3T3[XNCVkeHUh?=
SW48 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfNOoFKSzVyPUCuNFUxOzlizszN MXvTRW5ITVJ?
YKG-1 NUnuPVVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoGxTWM2OD1yLkC1NFcyKM7:TR?= Mm\2V2FPT0WU
KYSE-150 NHH5VI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3JV|RUUUN3ME2wMlA2OjN3IN88US=> NVHIT5d2W0GQR1XS
HuO-3N1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEWyN|ch|ryP MkfYV2FPT0WU
LB1047-RCC MkLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzob3hKSzVyPUCuNFUzQTZizszN MoHTV2FPT0WU
NCI-H2030 NWK5bVBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETqNWRKSzVyPUCuNFU1OTRizszN NGnJZWtUSU6JRWK=
YH-13 NVrWRoJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m2WGlEPTB;MD6wOVczOiEQvF2= MkjYV2FPT0WU
5637 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHqTWM2OD1yLkC1O|Qh|ryP MlnaV2FPT0WU
LOXIMVI MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknNTWM2OD1yLkC1PFczKM7:TR?= NFrUOYdUSU6JRWK=
GT3TKB NGi0ZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHYRpdKSzVyPUCuNFU6PDJizszN MW\TRW5ITVJ?
TCCSUP NXPqdHNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXLTWM2OD1yLkC1PVY1KM7:TR?= MVPTRW5ITVJ?
EPLC-272H M3Hhbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHNTWM2OD1yLkC2NlA2KM7:TR?= NFm2e|NUSU6JRWK=
LU-99A M2fYV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmCxTWM2OD1yLkC2NlM4KM7:TR?= M4rPZXNCVkeHUh?=
NCI-H1755 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jNZmlEPTB;MD6wOlM1OSEQvF2= MV;TRW5ITVJ?
KM12 M3;rNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnUNWZKSzVyPUCuNFY{PDhizszN MlrKV2FPT0WU
SF295 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnOTWM2OD1yLkC2OFUzKM7:TR?= MWjTRW5ITVJ?
MZ2-MEL Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwME[1OVMh|ryP NUTsT5VIW0GQR1XS
HEC-1 NHXOU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwME[1PFgh|ryP M373WHNCVkeHUh?=
SW684 NUjYTXBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwME[1PVEh|ryP NIi0Z4FUSU6JRWK=
SF539 NXv1ZZVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPteFhUUUN3ME2wMlA3PjhzIN88US=> NESyZ4NUSU6JRWK=
GMS-10 MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW3VZhsUUN3ME2wMlA3Pjl7IN88US=> NInie|lUSU6JRWK=
MV-4-11 M3L1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYGxcHRrUUN3ME2wMlA3QDB|IN88US=> NX\hUI02W0GQR1XS
HT-29 NFnQZ2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n0PGlEPTB;MD6wOlkyQSEQvF2= M2nDXXNCVkeHUh?=
23132-87 NF\helNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr6TWM2OD1yLkC2PVUh|ryP MUHTRW5ITVJ?
SW620 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTrW29KSzVyPUCuNFcxOjZizszN NVLpVYdlW0GQR1XS
HCC1806 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TQW2lEPTB;MD6wO|E{OSEQvF2= NVjPVo15W0GQR1XS
Hs-578-T MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEeyNFgh|ryP NGflO2hUSU6JRWK=
A2058 M3Tqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHPPZRKSzVyPUCuNFczOjhizszN NFe0ZphUSU6JRWK=
MEL-HO MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjk[YpKSzVyPUCuNFczPTVizszN MVrTRW5ITVJ?
HCC2998 NFn3PWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rtd2lEPTB;MD6wO|M1PyEQvF2= M2fRXHNCVkeHUh?=
HuO9 M4PLfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS2Nm9KSzVyPUCuNFc2QDlizszN MoS1V2FPT0WU
CAL-39 NULCenNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSyTWM2OD1yLkC3O|Y3KM7:TR?= MmTWV2FPT0WU
M14 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq2TWM2OD1yLkC3PVE{KM7:TR?= M333eXNCVkeHUh?=
BFTC-909 M3Xjd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLFXGVKSzVyPUCuNFc6PjlizszN MU\TRW5ITVJ?
TE-11 NH7seVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDOTWM2OD1yLkC3PVk3KM7:TR?= NGrQS41USU6JRWK=
TGBC1TKB NILFdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEiwOFMh|ryP NYLBXIRKW0GQR1XS
L-363 NEfrSllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vnWmlEPTB;MD6wPFIxPiEQvF2= NX;S[Vh7W0GQR1XS
A431 NGPXTJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnmTWM2OD1yLkC4NlEh|ryP MkjIV2FPT0WU
MKN45 Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vXZmlEPTB;MD6wPFIyQSEQvF2= MY\TRW5ITVJ?
HT-1080 NILmRXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES2UoFKSzVyPUCuNFg1OzlizszN NYHUc|BxW0GQR1XS
OVCAR-8 M2PadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEi2NlIh|ryP NFXtW49USU6JRWK=
LCLC-97TM1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\NSlg5UUN3ME2wMlA5PzJ6IN88US=> M{Hx[XNCVkeHUh?=
M059J MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrjdZN3UUN3ME2wMlA6ODJ5IN88US=> NGeydIVUSU6JRWK=
SK-MEL-2 MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HzRmlEPTB;MD6wPVA3KM7:TR?= MoO0V2FPT0WU
TE-1 M{jCZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3ETWM2OD1yLkC5NlA1KM7:TR?= M2PaUnNCVkeHUh?=
KYSE-180 M1TSfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nvc2lEPTB;MD6wPVI3OiEQvF2= NX7RfXdbW0GQR1XS
D-247MG NFvNd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMEm0OVUh|ryP MnjUV2FPT0WU
8-MG-BA MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEm0O|Ih|ryP NFrR[oRUSU6JRWK=
NCI-H1792 MlfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Xze2lEPTB;MD6wPVYyQCEQvF2= M4jRNXNCVkeHUh?=
MCF7 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXifG1DUUN3ME2wMlA6Pjd5IN88US=> MorGV2FPT0WU
NCI-H2122 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEOxNFlKSzVyPUCuNFk4PDVizszN Mn7tV2FPT0WU
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LB2241-RCC NYe2UWZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMUCwOVQh|ryP NWLJVWdRW0GQR1XS
SN12C NXXEXVZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PlRWlEPTB;MD6xNFExPyEQvF2= Mn7sV2FPT0WU
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NCI-H1581 NVu1WlRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMUCyPUDPxE1? NXjrbIRNW0GQR1XS
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U251 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDn[3psUUN3ME2wMlExPTJ3IN88US=> NV;1VowxW0GQR1XS
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BB65-RCC NFS2dpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;XR2lEPTB;MD6xNFU2PCEQvF2= M4\IZnNCVkeHUh?=
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SH-4 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[wW|VKSzVyPUCuNVE{PTZizszN NH7CWI9USU6JRWK=
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RKO M4[4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLr[|cyUUN3ME2wMlEyPzZ2IN88US=> NVP1eGp6W0GQR1XS
OMC-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy0c3dTUUN3ME2wMlEyPzl5IN88US=> NH3uXVVUSU6JRWK=
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COLO-829 NH:xUItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv5WI1sUUN3ME2wMlEzODB3IN88US=> NHXQRVJUSU6JRWK=
HMV-II MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvTWFZKSzVyPUCuNVIxOiEQvF2= NXXiW|RtW0GQR1XS
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NCI-H1437 M1fIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n3eWlEPTB;MD6xNlE2PyEQvF2= M33IUXNCVkeHUh?=
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PC-14 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvLVlVEUUN3ME2wMlE{OjFzIN88US=> M3XH[nNCVkeHUh?=
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LB831-BLC MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;GOYVKSzVyPUCuNVM5QDNizszN Mn32V2FPT0WU
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RT-112 MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV75T5R[UUN3ME2wMlE1ODN3IN88US=> MWHTRW5ITVJ?
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NUGC-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnRcFlSUUN3ME2wMlE1PDd6IN88US=> NXjYfWxHW0GQR1XS
GI-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMUS1OVgh|ryP NEnlVVhUSU6JRWK=
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CAL-62 Mm[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf4VIVGUUN3ME2wMlE3OTZ7IN88US=> NXjhVYlXW0GQR1XS
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NCI-H2087 NIPFUmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvTdGZtUUN3ME2wMlE4OzZ6IN88US=> M1m5ZnNCVkeHUh?=
NCI-H2170 Mn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnkT5NKSzVyPUCuNVc2OzZizszN MUDTRW5ITVJ?
SK-OV-3 NGHNUmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHsTWM2OD1yLkG3OVcyKM7:TR?= MUXTRW5ITVJ?
MZ7-mel NFjOW2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnWwTWM2OD1yLkG3OlQ6KM7:TR?= M37TVHNCVkeHUh?=
NCI-H650 NIPoXIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojFTWM2OD1yLkG3OlgzKM7:TR?= NWjoPXR{W0GQR1XS
KOSC-2 MoPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;JTWM2OD1yLkG3O|M1KM7:TR?= NFnPRXZUSU6JRWK=
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MDA-MB-157 NXvlS49JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHlbnFyUUN3ME2wMlE5ODh{IN88US=> NIDQbWNUSU6JRWK=
KYSE-520 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTiS|BKSzVyPUCuNVgzKM7:TR?= M1fjWHNCVkeHUh?=
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IGROV-1 NYLRd3I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnPTWM2OD1yLkG4OFQ{KM7:TR?= NW\XdJQ{W0GQR1XS
DEL NXfFfZh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DHe2lEPTB;MD6xPFQ2KM7:TR?= NYThS29wW0GQR1XS
NCI-H1395 NYTlWZo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMUi2PFIh|ryP Mo\EV2FPT0WU
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BCPAP M37Icmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMUi4O|Ih|ryP Mn7jV2FPT0WU
CAL-27 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rk[mlEPTB;MD6xPVAzOiEQvF2= NF:3WHpUSU6JRWK=
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NCI-H1650 NHnD[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ji[mlEPTB;MD6yNFA2PyEQvF2= NIrEcVhUSU6JRWK=
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NCI-H747 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:wTWM2OD1yLkK0NVY6KM7:TR?= NXP4OVdNW0GQR1XS
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OS-RC-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHpSVhtUUN3ME2wMlI1PTB7IN88US=> MVnTRW5ITVJ?
KINGS-1 M4jCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMkS1Nlkh|ryP NV;EcJdVW0GQR1XS
SCC-25 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnKeopjUUN3ME2wMlI1PTZ|IN88US=> MY\TRW5ITVJ?
CAPAN-1 NVvqbGk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i2eGlEPTB;MD6yOFc5OyEQvF2= MVvTRW5ITVJ?
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TE-5 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml21TWM2OD15LkSxNlk5KM7:TR?= NFrN[FFUSU6JRWK=
P12-ICHIKAWA NFLqZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTdwNEW1NlMh|ryP M{HXSHNCVkeHUh?=
NCI-H82 MlvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTdwNEW3NFEh|ryP NWj1VXpyW0GQR1XS
NCI-H1993 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfSbY9IUUN3ME23Mlg{ODZ|IN88US=> NHjZcnNUSU6JRWK=
RH-1 NGXvRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLnTWM2OD15Lki1NlQ1KM7:TR?= NX;nXlJ3W0GQR1XS
SW948 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\MTWM2OD15Lkm2NFQ6KM7:TR?= M13QcnNCVkeHUh?=
CAL-33 MkDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXzTWM2OD15Lkm5PVM5KM7:TR?= MXvTRW5ITVJ?
U-266 NWq1T5NVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrBV|JKSzVyPUiuNVU4PzdizszN M{HocHNCVkeHUh?=
CAL-72 NX64dHc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7MTWM2OD16LkKwN|Ih|ryP NYC2dWJOW0GQR1XS
SNU-423 M3zBXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfzepVKSzVyPUmuN|Y3PjZizszN MVPTRW5ITVJ?
KG-1 NXruSoYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nlNmlEPTB;OT61PFQ2PiEQvF2= MUHTRW5ITVJ?
HCC1395 M2r0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHryUGFKSzVyPUmuPVI{PTJizszN NWS2XopTW0GQR1XS
BE-13 NVHYclB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXoZ5VOUUN3ME2xNE45QDl{IN88US=> NIfyVm5USU6JRWK=
MKN7 NWfCVI5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnReHlKSzVyPUGwMlk4PjVizszN MXrTRW5ITVJ?
697 MofsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLPNlhKSzVyPUGxMlE1PzJizszN M3HUNHNCVkeHUh?=
LU-135 NYPIbFA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFzLkKzNFch|ryP M1HXS3NCVkeHUh?=
ES7 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXLTWM2OD1zMT6zN|E{KM7:TR?= NIHQeG1USU6JRWK=
SK-HEP-1 MnK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MormTWM2OD1zMT63OlQ3KM7:TR?= MoTTV2FPT0WU
BEN MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MormTWM2OD1zMT64OVEh|ryP MW\TRW5ITVJ?
NCI-H1770 NWXH[pBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTF{LkGyOkDPxE1? MlriV2FPT0WU
SW13 MmXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDUTWM2OD1zMj6xOVQyKM7:TR?= M3H1XXNCVkeHUh?=
MZ1-PC NWDFOng3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHWfIFKSzVyPUGyMlU1PTJizszN NF;US2ZUSU6JRWK=
Mo-T MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvOTWdKSzVyPUGyMlc1OjFizszN MWnTRW5ITVJ?
HLE NGTGOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LVe2lEPTB;MUKuPFIyPSEQvF2= M3z2fXNCVkeHUh?=
RCC10RGB NFnBSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK3XppKSzVyPUGzMlY4OSEQvF2= MkXMV2FPT0WU
COLO-320-HSR NX;vOFhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEL5U|FKSzVyPUGzMlc{QDFizszN NGDrRWhUSU6JRWK=
BHT-101 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC5R29KSzVyPUGzMlg{PDVizszN Mln6V2FPT0WU
OCUB-M NVHLNWZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3JXHdKSzVyPUG0MlE3ODJizszN NET3UnlUSU6JRWK=
MEG-01 Mnm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TJbWlEPTB;MUSuN|cxQCEQvF2= MonYV2FPT0WU
RS4-11 M2L0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULKWIZJUUN3ME2xOE44PDJizszN M{XSeXNCVkeHUh?=
MN-60 NF7BWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rqVWlEPTB;MUSuO|g6PCEQvF2= M3;jfXNCVkeHUh?=
NCI-H1304 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH3W|NKSzVyPUG1MlA1OjVizszN NYC1doUyW0GQR1XS
Ramos-2G6-4C10 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zQ[mlEPTB;MUWuNFU5OSEQvF2= MkD1V2FPT0WU
NCI-H2342 NGnxTXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTF3LkKwOFQh|ryP MkfyV2FPT0WU
LAN-6 MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF3LkS0NVQh|ryP NH;ZSohUSU6JRWK=
JVM-2 MnKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfodVRKSzVyPUG1MlU4PDhizszN MmPvV2FPT0WU
P30-OHK NGjITZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHhTpFKSzVyPUG2MlA3OTRizszN NYTBdFJbW0GQR1XS
C-33-A NV\sOVhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7DTWM2OD1zNj62NlE1KM7:TR?= MWXTRW5ITVJ?
RPMI-8866 M3nE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF4Lki0PVYh|ryP NFHLWWlUSU6JRWK=
NCI-H630 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn3ZWdxUUN3ME2xOk45PTN5IN88US=> NUTHeldnW0GQR1XS
KYSE-140 MmnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELETlFKSzVyPUG3MlIxOjhizszN Ml7ZV2FPT0WU
T84 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3seYxKSzVyPUG4Mlg3QTVizszN M4XUeHNCVkeHUh?=
KU-19-19 M3X6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q4SGlEPTB;MUiuPVYxQCEQvF2= NIizeIRUSU6JRWK=
BALL-1 NH;MR5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXaTItQUUN3ME2xPU4{Ozl7IN88US=> M13LXnNCVkeHUh?=
Calu-6 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTXWWhKSzVyPUG5MlQ6OiEQvF2= NWLIWFNPW0GQR1XS
EGI-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnoc4xKSzVyPUG5MlU6QCEQvF2= NHr4SWJUSU6JRWK=
MFH-ino NIn2UHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTF7Lke0OVQh|ryP NWPhT2t{W0GQR1XS
GB-1 MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfoNHhKSzVyPUKwMlM2OzVizszN M3LZWXNCVkeHUh?=
NCI-H1693 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\TO3ZKSzVyPUKwMlY2ODVizszN MojHV2FPT0WU
SW1116 NVy2SY9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTuTWM2OD1{MD65N|YzKM7:TR?= M4\VOnNCVkeHUh?=
H-EMC-SS NVPSSWVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3NcJNiUUN3ME2yNk4xPDVizszN M3S2OHNCVkeHUh?=
D-502MG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETVNHVKSzVyPUKyMlgzPjFizszN Mk\4V2FPT0WU
IA-LM MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moe3TWM2OD1{Mz6yOFk{KM7:TR?= M3K5UXNCVkeHUh?=
SW1463 NWjmbmRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLTTWM2OD1{Mz63PUDPxE1? NEXWSYZUSU6JRWK=
JAR MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXEOZFIUUN3ME2yOE4{Ojl|IN88US=> M3Lsd3NCVkeHUh?=
HT MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPwT5RQUUN3ME2yOE41PzV|IN88US=> M4H6OnNCVkeHUh?=
LCLC-103H M4nnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUO2XY46UUN3ME2yOE45PDR7IN88US=> NGfsVpdUSU6JRWK=
SNU-449 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HHRmlEPTB;MkSuPFc1OSEQvF2= MljjV2FPT0WU
KE-37 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH4PYduUUN3ME2yOU4xQTJ6IN88US=> M2nqcnNCVkeHUh?=
NCI-H1623 NVvq[IF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP5TWM2OD1{Nz6xN|A{KM7:TR?= M3\hTHNCVkeHUh?=
MOLT-13 NILzbGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrWdY5CUUN3ME2yO{4{PTF4IN88US=> M3LIZ3NCVkeHUh?=
COLO-741 NIHTS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjvXGVKSzVyPUOxMlM{OzNizszN M{P6WXNCVkeHUh?=
NB6 M1X5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fOcmlEPTB;M{KuNlg4PiEQvF2= NWq5dHo1W0GQR1XS
MOLT-16 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnhTWM2OD1|Mz6wNFU2KM7:TR?= NXr6[GllW0GQR1XS
IST-MES1 NVfMTZM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEW1UppKSzVyPUO0MlA2PDFizszN MnTiV2FPT0WU
A4-Fuk NVnyenNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrHWmlFUUN3ME2zOU4xPjZizszN MWjTRW5ITVJ?
CAL-85-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTN3LkK4NVch|ryP NEPX[HZUSU6JRWK=
CCRF-CEM MnyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrjTWM2OD1|Nz6xOVM3KM7:TR?= NYHMVFl1W0GQR1XS
HAL-01 M13oR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1GzXWlEPTB;M{iuOFg5QSEQvF2= NHrxXXBUSU6JRWK=
HEL NV3UblNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\YZolKSzVyPUSzMlM1ODlizszN NVfWdoNoW0GQR1XS
EW-1 M2PPXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTR|LkS3Olgh|ryP MUfTRW5ITVJ?
MDA-MB-231 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTR3LkGxPVkh|ryP M3HNNXNCVkeHUh?=
ABC-1 NWT1b|dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXXZWRKSzVyPUS2Mlg2OzhizszN MULTRW5ITVJ?
NCI-H446 NYnwSIlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7BbVZKSzVyPUS4MlUxPThizszN MUfTRW5ITVJ?
MHH-PREB-1 NXHaU4dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nObmlEPTB;NEmuOlAxPyEQvF2= M1u0VXNCVkeHUh?=
DOHH-2 NU\4THl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV70VIZTUUN3ME20PU43PjV4IN88US=> MoW5V2FPT0WU
GCT MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHvTWM2OD12OT62PVc3KM7:TR?= NV7oTGl6W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo試験 17-AAG displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice with IC50 values of 8-35 nM as compared with that from the normal tissues with IC50 values of 200-600 nM. [1] Administration of 17-AAG (~50 mg/kg) causes significant decline in AR, HER2, HER3, and Akt expression in a dose-dependent manner with >50% decline at dose of 50 mg/kg, resulting in the dose-dependent inhibition of androgen-dependent (CWR22) and -independent (CWR22R and CWRSA6) prostate cancer xenografts growth by 67%, 80% and 68% at dose of 50 mg/kg, respectively. [2]
臨床試験 A Phase II study of 17-AAG in patients with relapsed/refractory CD30 plus anaplastic large cell lymphoma (ALCL) relapsed/refractory mantle cell lymphoma (MCL) and relapsed/refractory classical Hodgkin's lymphoma (HL) has been completed.
特集 Displays very low toxicity toward normal cells.

プロトコル (参考用のみ)

キナーゼアッセイ: [1]

Hsp90 binding assays Purified native Hsp90 protein or cell lysates from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells in lysis buffer (20 mM HEPES, pH 7.3, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) are incubated with various concentrations of 17-AAG for 30 minutes at 4 °C, and then incubated with biotin-GM linked to BioMag streptavidin magnetic beads for 1 hour at 4 °C. Tubes are placed on a magnetic rack, and the unbound supernatant removed. The magnetic beads are washed three times in lysis buffer and heated for 5 minutes at 95 °C in SDS–PAGE sample buffer. Samples are analysed on SDS protein gels, and western blots done using indicated antibodies. Bands in the western blots are quantified using the Bio-rad Fluor-S MultiImager, and the percentage inhibition of binding of Hsp90 to the biotin-GM is calculated. The IC50 reported is the concentration of 17-AAG needed to cause half-maximal inhibition of binding.

細胞アッセイ: [1]

細胞株 BT474, SKBR3, N87, SKOV3, MCF7, MDA468, Hs578T, Hs578Bst, A549, HT29, U87, SKMG3, HT1080, RPTEC, NDF, HMVEC, HMEC, HUVEC, and PBMC cells
濃度 Dissolved in DMSO, final concentrations ~10 μM
反応時間 5 days
実験の流れ Cells are seeded in 96-well plates at 2,000 cells per well in a final culture volume of 100 μL for 24 hours before the addition of increasing concentrations of 17-AAG that is incubated for 5 days. Viable cell number is determined using the Celltiter 96 AQueous Nonradioactive Cell Proliferation Assay. The value of the background absorbance at 490 nm (A490) of wells not containing cells is subtracted. Percentage of viable cells = (A490 of 17-AAG treated sample/A490 untreated cells) × 100. The IC50 is defined as the concentration that gave rise to 50% viable cell number.

動物実験: [2]

動物モデル Male nu/nu athymic mice inoculated s.c. with androgen-dependent CWR22 xenograft, and female nu/nu athymic mice inoculated s.c. with androgen-independent xenografts CWR22R and CWRSA6
製剤 Dissolved in DMSO, and diluted in egg phospholipids (EPL) vehicle
投薬量 ~50 mg/kg
投与方法 Injection i.p.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

参考

化学情報

Download 17-AAG (Tanespimycin) SDF
分子量 585.69
化学式

C31H43N3O8

CAS No. 75747-14-7
保管 2年-20℃
6月-80℃in solvent
別名 CP127374,NSC-330507, KOS 953
溶解度 (25°C) * In vitro DMSO 100 mg/mL (170.73 mM)
エタノール 5 mg/mL (8.53 mM)
<1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
化学名 17-demethoxy-17-(2-propenylamino)- [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate

カスタマーフィードバック (7)


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Source , , PNAS, 2011, 108: 7535-40. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines H3122 & H3122 CR cells
Concentrations 10 nM
Incubation Time 72 h
Results As shown in Fig. A, 17-AAG potently suppressed cell growth in both parental H3122 and H3122 CR cells. However, in contrast to NVP-TAE684 and AP26113, 17-AAG also inhibited the viability of SKBR3 and BT474 cell lines. 17-AAG treatment decreased both p-ALK 眏Ỵ眐㠞眎膉癠 皐﷘ř᐀ŔřĀ 㺣癞帉癞Ѐ瑖兽ﱔᆊࣿřĀࣾ彿兾奋兾巫兾婶ࣿ橢ࣿ彿兾

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Rating
Source Oncotarget, 2014, 5, 4269-82. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines Ls-174T, HCT116, Caco2, Hke3 cells
Concentrations 0.5, 2 uM
Incubation Time 24 h
Results Colon cancer cells harboring WT or MT K-Ras were treated with 17-AAG and effects on the Ras expression were analyzed by WB. Results in Figure showed that incubation with 17-AAG only down-regulates K-Ras in K-Ras MT cells but decreases Raf-1 {an established Hsp90 client} in all cell lines. The result, for the first time, demonstrated that both transfected and endogenous MT K-Ras is an Hsp90 client protein.

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Rating
Source Oncotarget, 2015, 51: S659-S660. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines MOLT-4 & RS4;11 cells
Concentrations
Incubation Time 22 h
Results In both MOLT-4 and RS4;11 cells, the combined treatment inhibited the interactions between Hsp90 and BIP/Grp78 more effectively than CX-4945 single treatment and to the same extent as tanespimycin (17-AAG).

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Rating
Source Mol Cell Biol, 2013, 33(12), 2375-87. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines NIH 3T3 cells
Concentrations 25, 50 uM
Incubation Time 4 h
Results 17-AAG and SNX-2112, both of which induce the UPR by targeting the chaperone HSP90, decreased mSmoM2 protein levels (lanes 2 to 5 compared to lane 1), further supporting the sensitivity of active Smo mutants to UPR induction.

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Rating
Source J Biol Chem, 2012, 287, 44109-20. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines Dopaminergic Neuronal Cell lines
Concentrations 10-20uM
Incubation Time
Results As expected, both complex IV activity and Hsp60 levels exhibited a dose-dependent decrease in response to treatment with 17-AAG (Fig. 4A). However, 17-AAG treatment did not alter levels of Hsp90 and LRPPRC levels

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Rating
Source Mol Cancer, 2014, 13, 150. 17-AAG (Tanespimycin) purchased from Selleck
Method Western blot
Cell Lines SKBR3 cells
Concentrations 1, 2 uM
Incubation Time 24 h
Results Hsp90 and Cdc37 protein levels showed no distinct change according to a drug concentration gradient, whereas Hsp70, a marker of Hsp90 inhibition, the protein level was greatly induced by treatment with 17AAG or FW-04-806.

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Rating
Source Age, 2013, 35, 549-62. 17-AAG (Tanespimycin) purchased from Selleck
Method Western Blot
Cell Lines HFSN1 cells
Concentrations 0.1/0.5uM
Incubation Time 24 h
Results Figure 2c shows that the decrease in the level of Hsp90 after treatment with 0.5 μM of 17-AAG was accompanied by a decrease in the level of both the survivin and phospho-survivin proteins.

文献中の引用 (19)

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    Luminespib (AUY-922, NVP-AUY922)は高度的に HSP90 を抑制、 HSP90α と HSP90β を作用すると、 IC50 がそれぞれ 13 nM 、 21 nM となる。

  • Ganetespib (STA-9090)

    Ganetespib (STA-9090)は独特な triazolone-containing Hsp90阻害剤、 IC50 が4 nM となる.

  • 17-DMAG (Alvespimycin) HCl

    17-DMAG (Alvespimycin) HClは、62nMのIC50による強力なHsp90阻害剤です。

    Features:A synthetic derivative Geldanamycin, with lower hepatotoxicity than parent antibiotic & higher potency and bioavailability than the similar derivative 17-AAG.

  • Geldanamycin

    ノーカット二量体Hsp90またはN末端領域Hsp90と結合している間、Geldanamycinは1.2のμMまたは0.78のμMによるKdによる天然既存のHsp90阻害剤です。

  • HSP990 (NVP-HSP990)

    NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

    Features:NVP-HSP990 is an orally available HSP90 inhibitor and is structurally distinct from other clinical HSP90 inhibitors.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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