5-HT Receptor

5-HT Receptor 阻害剤 | 作動薬 | 拮抗剤 | モジュレータ (69)


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S2459 Clozapine Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis.
S2493 Olanzapine Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.
S2232 Ketanserin Ketanserin is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A.
S1333 Fluoxetine HCl Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI)class.
S1245 Latrepirdine Latrepirdine is an antihistamine drug.
S4694 Alosetron Hydrochloride
S4635 Cyproheptadine hydrochloride
S8183 Pimavanserin Pimavanserin is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.
S1436 Tianeptine sodium Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE) compound used for treating major depressive episodes.
S2698 RS-127445 RS-127445は、pKi==9.5±0.1とpIC50 =10.4±0.1による選択性の高いオートフォーカスfi死亡率が高い5-HT2B受容体拮抗剤です。
S8021 Vortioxetine (Lu AA21004) HBr Vortioxetine (Lu AA21004) HBrは、経口多モード血清トン作動性薬剤で、 5-HT(1A)5-HT(1B)5-HT(3A)5-HT(7)SERTに作用すると、IC50がそれぞれ15 nM、33 nM、3.7 nM、19 nM、1.6 nMです。
S8010 PRX-08066 Maleic acid PRX-08066 Maleic acidは、選択的な5-HT2B 敵対者で、IC50 が3.4 nMです。
S4256 Buspirone HCl Buspirone HCl is a multi-targeted antianxiety drug used for anxiety disorders.
S4259 Vilazodone HCl KALA peptide binds oligonucleotides and disrupts cell membrane; therefore, it can be used as a DNA transfection reagent.
S4249 Flopropione Flopropione is a spasmolytic or antispasmodic agent, acts as a 5-HT1A receptor antagonist.
S4247 Prucalopride Succinate Prucalopride is a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements.
S1243 Agomelatine Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
S1390 Ondansetron HCl Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
S1345 Granisetron HCl Granisetron HCl is a serotonin 5-HT3 receptor antagonist.
S1869 Dapoxetine HCl Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor.
S2677 BRL-15572 BRL-15572は、7.9のpKiをもつセロトニン受容体サブタイプ5-HT1D敵対者です。
S1607 Rizatriptan Benzoate Rizatriptan Benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.
S2856 SB271046 SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.
S2669 LY310762 LY310762は、中央0.2μMのKiによるモルモット5-HT1Dレセプターのための5-HT1Dセロトニン受容体拮抗剤です。
S1444 Ziprasidone HCl Ziprasidone HCl was the fifth atypical antipsychotic.
S1283 Asenapine maleate Asenapine maleate inhibits adrenergic receptor1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
S1996 Ondansetron Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
S2582 Trazodone HCl Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
S2691 BMY 7378 BMY 7378は、α<下位>2C</サブ>-副腎受容体</b>、<b>α<サブ>1D の複数の阻害剤で、pKi がそれぞれ 6.54 と 8.2です。
S1432 Sumatriptan Succinate Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.
S1615 Risperidone Risperidone is an atypical antipsychotic used to treat schizophrenia.
S1642 Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
S1649 Zolmitriptan Zolmitriptan is a selective serotonin receptor agonist.
S2541 Clomipramine HCl Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
S1975 Aripiprazole Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
S1394 Pizotifen Malate Pizotifen Malate is a benzocycloheptane based agent used for recurrent migraine headaches.
S3183 Amitriptyline HCl Amitriptyline HCl inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.
S4244 Serotonin HCl Serotonin HClはモノアミン神経伝達物質および内因性5-HT受容体アゴニストです。
S1385 Mosapride Citrate Mosapride Citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
S3180 Eletriptan HBr Eletriptan HBr is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.
S2663 WAY-100635 Maleate WAY-100635 Maleateは、0.95nMのIC50による5-HTのための強力で選択的な5-hydroxytryptamine1A拮抗剤です。
S2346 Puerarin Puerarin is a 5-HT2C receptor and benzodiazepine site antagonist.
S3005 Paroxetine HCl Paroxetine HCl is an antidepressant drug of the SSRI type.
S3024 Lamotrigine ラモトリジンは、240μMと474μMのIC50によるヒト血小板とネズミ脳シナプトソームの5-ヒドロキシトリプタミン(5-HT)取り込みの抑制のための新しい抗痙攣剤です。
S2852 BRL-54443 BRL-54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively.
S2106 Azasetron HCl Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
S2084 Duloxetine HCl Duloxetine HCl is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
S1336 Fluvoxamine maleate Fluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI)
S2016 Mirtazapine Mirtazapine is a potent tetracyclic antidepressant.
S2849 SB269970 HCl SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3.
S2894 SB742457 SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.
S2112 Blonanserin Blonanserin is a relatively selective serotonin (5-HT)2A and dopamine D2 antagonist, used the treatment of schizophrenia.
S3050 Palonosetron HCl Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
S3140 Milnacipran HCl Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.
S3175 Atomoxetine HCl Atomoxetine HCl is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
S1441 Venlafaxine Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI).
S2025 Urapidil HCl Urapidil HCl is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.
S2865 VUF 10166 VUF 10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
S2096 Almotriptan Malate Almotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
S1488 Naratriptan Naratriptan is a triptan agent that is used for the treatment of migraine headaches.
S4113 Desvenlafaxine Desvenlafaxineは セロトニン(5-HT)ノルエピネフリン(NE)の再取り込み阻害剤で、Ki がそれぞれ40.2 nM と 558.4 nMです。
S4053 Sertraline HCl Sertraline HCl is a 5-HT inhibitor with Ki of 13 nM.
S4064 Escitalopram Oxalate Escitalopram Oxalateは、選択的なセロトニン(5-HT)再摂取阻害剤(SSRI)で、Ki が0.89 nMです。
S4086 Loxapine Succinate Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
S4109 Lorcaserin HCl Lorcaserin HClが人間 5-HT2Cの選択フルアゴニスト受容体で、Ki が15 nMです。
S1898 Tropisetron HCl Tropisetron HCl is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
S2875 Prucalopride Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes. Phase 3.
S1483 Iloperidone Iloperidone is an atypical antipsychotic for the treatment of schizophrenia.
S4112 Desvenlafaxine Succinate Desvenlafaxine Succinateは、新規の セロトニン(5-HT) のトランスポーターと ノルエピネフリン(NE) のトランスポーターが再取り込み阻害剤で、Ki がそれぞれ 40.2 nM と 558.4 nM です。