• ROCK製品生物活性の比較
  • 研究分野

ROCK 阻害剤 (8)


製品コード 製品名 製品説明 文献中の引用 カスタマーフィードバック
S1049 Y-27632 2HCl Y-27632 2HClはRho関連プロテインキナーゼ1(ROCK1、p160ROCK)選択阻害剤、Kiが140nMになる。
S1459 Thiazovivin Thiazovivinは、小説ROCK阻害剤で、 IC50 が ~0.5 μMです。
S1573 Fasudil (HA-1077) HCl Fasudil (HA-1077) HCl is cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor with an IC50 of 10.7 μM.
S1474 GSK429286A GSK429286Aは、ROCK1とROCK2の選択的な阻害剤で、 IC50 がそれぞれ 14 nM と 63 nMになる。
S7195 RKI-1447 RKI-1447 is a potent inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 6 nM, respectively.
S7936 KD025 (SLx-2119) KD025 is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nm, respectively. Phase 2.
S7995 Ripasudil (K-115) Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.
S7563 AT13148 AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.